ID   Q92862_HUMAN            Unreviewed;        77 AA.
AC   Q92862;
DT   01-FEB-1997, integrated into UniProtKB/TrEMBL.
DT   01-FEB-1997, sequence version 1.
DT   27-MAR-2024, entry version 89.
DE   SubName: Full=Dynein heavy chain {ECO:0000313|EMBL:AAC50701.1};
DE   Flags: Fragment;
GN   Name=Dnchc1 {ECO:0000313|EMBL:AAC50701.1};
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae;
OC   Homo.
OX   NCBI_TaxID=9606 {ECO:0000313|EMBL:AAC50701.1};
RN   [1] {ECO:0000313|EMBL:AAC50701.1}
RP   NUCLEOTIDE SEQUENCE.
RC   TISSUE=Lung {ECO:0000313|EMBL:AAC50701.1};
RX   PubMed=8812413; DOI=10.1006/geno.1996.0422;
RA   Vaughan K.T., Mikami A., Paschal B.M., Holzbaur E.L.F., Hughes S.M.,
RA   Echeverri C.J., Moore K.J., Gilbert D.J., Copeland N.G., Jenkins N.A.,
RA   Vallee R.B.;
RT   "Multiple mouse chromosomal loci for dynein-based motility.";
RL   Genomics 36:29-38(1996).
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DR   EMBL; U61737; AAC50701.1; -; mRNA.
DR   AlphaFoldDB; Q92862; -.
DR   PeptideAtlas; Q92862; -.
DR   ChiTaRS; DYNC1H1; human.
DR   GO; GO:0030286; C:dynein complex; IEA:InterPro.
DR   GO; GO:0005524; F:ATP binding; IEA:InterPro.
DR   GO; GO:0045505; F:dynein intermediate chain binding; IEA:InterPro.
DR   GO; GO:0051959; F:dynein light intermediate chain binding; IEA:InterPro.
DR   GO; GO:0008569; F:minus-end-directed microtubule motor activity; IEA:InterPro.
DR   GO; GO:0007018; P:microtubule-based movement; IEA:InterPro.
DR   Gene3D; 3.40.50.300; P-loop containing nucleotide triphosphate hydrolases; 1.
DR   InterPro; IPR035699; AAA_6.
DR   InterPro; IPR026983; DHC_fam.
DR   InterPro; IPR027417; P-loop_NTPase.
DR   PANTHER; PTHR46532:SF4; DYNEIN HEAVY CHAIN 8, AXONEMAL-LIKE PROTEIN; 1.
DR   PANTHER; PTHR46532; MALE FERTILITY FACTOR KL5; 1.
DR   Pfam; PF12774; AAA_6; 1.
DR   SUPFAM; SSF52540; P-loop containing nucleoside triphosphate hydrolases; 1.
PE   2: Evidence at transcript level;
FT   DOMAIN          1..77
FT                   /note="Dynein heavy chain hydrolytic ATP-binding dynein
FT                   motor region"
FT                   /evidence="ECO:0000259|Pfam:PF12774"
FT   NON_TER         1
FT                   /evidence="ECO:0000313|EMBL:AAC50701.1"
FT   NON_TER         77
FT                   /evidence="ECO:0000313|EMBL:AAC50701.1"
SQ   SEQUENCE   77 AA;  8307 MW;  0C0CF2985B067040 CRC64;
     TPLTDRCYLT MTQALEARLG GSPFGPAGTG KTESVKALGH QLGRFVLVFN CDETFDFQAM
     GRIFVGLCQV GAWGCFD
//