Skip Header

 
Contribute Send feedback
Read comments (1) or add your own

Reviewed, UniProtKB/Swiss-Prot Q92858 (ATOH1_HUMAN)

Last modified June 16, 2009. Version 71. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Protein atonal homolog 1
Alternative name(s):
    Helix-loop-helix protein hATH-1
Gene names
Name: ATOH1
Synonyms: ATH1
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Function

Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription By similarity.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
Gene Ontology (GO)
   Biological processtranscription from RNA polymerase II promoter Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular functiontranscription factor activity Ref.1

Traceable author statement. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Protein atonal homolog 1
PRO_0000127139

Regions

Domain172 – 21241Helix-loop-helix motif
DNA binding160 – 17112Basic motif
Compositional bias29 – 3810Poly-Pro
Compositional bias224 – 2285Poly-Pro

Natural variations

Natural variant2371H → Q: dbSNP rs35182771.
VAR_049539

Sequences

Sequence LengthMass (Da)Tools
Q92858-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AB12F1E917A00A8D

FASTA35438,160
        10         20         30         40         50         60 
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD 

        70         80         90        100        110        120 
PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG 

       130        140        150        160        170        180 
PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD 

       190        200        210        220        230        240 
QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT 

       250        260        270        280        290        300 
AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS 

       310        320        330        340        350 
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis."
Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y.
Hum. Mol. Genet. 5:1207-1216(1996) [PubMed: 8872459] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

U61148 Genomic DNA. Translation: AAB41305.1.
BC069145 mRNA. Translation: AAH69145.1.
BC069594 mRNA. Translation: AAH69594.1.
BC069604 mRNA. Translation: AAH69604.1.
BC113623 mRNA. Translation: AAI13624.1.
BC113625 mRNA. Translation: AAI13626.1.
IPIIPI00023811.
RefSeqNP_005163.1.
UniGeneHs.532680

3D structure databases

ModBaseSearch...

PTM databases

PhosphoSiteQ92858.

Proteomic databases

PRIDEQ92858.

Genome annotation databases

EnsemblENSG00000172238. Homo sapiens. [Contig view]
GeneID474.
KEGGhsa:474.

Organism-specific databases

GeneCardsGC04P095051.
HGNCHGNC:797. ATOH1.
MIM601461. gene.
PharmGKBPA25095.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ92858.
HOVERGENQ92858.
OMAQ92858. PSSKQVN.

Gene expression databases

ArrayExpressQ92858.
BgeeQ92858.
CleanExHS_ATOH1.
GermOnlineENSG00000172238. Homo sapiens.

Family and domain databases

InterProIPR001092. HLH_basic.
IPR011598. HLH_DNA_bd.
[Graphical view]
Gene3DG3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
PROSITEPS50888. HLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio1963.
SOURCESearch...

Entry information

Entry nameATOH1_HUMAN
AccessionPrimary (citable) accession number: Q92858
Secondary accession number(s): Q14CT9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents