Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92858 (ATOH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified February 19, 2014. Version 117. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein atonal homolog 1
Alternative name(s):
Class A basic helix-loop-helix protein 14
Short name=bHLHa14
Helix-loop-helix protein hATH-1
Short name=hATH1
Gene names
Name:ATOH1
Synonyms:ATH1, BHLHA14
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription By similarity.

Subunit structure

Efficient DNA binding requires dimerization with another bHLH protein.

Subcellular location

Nucleus Probable.

Sequence similarities

Contains 1 bHLH (basic helix-loop-helix) domain.

Ontologies

Keywords
   Biological processDifferentiation
Neurogenesis
Transcription
Transcription regulation
   Cellular componentNucleus
   Coding sequence diversityPolymorphism
   LigandDNA-binding
   Molecular functionActivator
Developmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processauditory receptor cell fate determination

Inferred from electronic annotation. Source: Ensembl

auditory receptor cell fate specification

Inferred from electronic annotation. Source: Ensembl

axon guidance

Inferred from electronic annotation. Source: Ensembl

central nervous system development

Traceable author statement Ref.1. Source: ProtInc

cerebral cortex development

Inferred from electronic annotation. Source: Ensembl

inner ear morphogenesis

Inferred from electronic annotation. Source: Ensembl

negative regulation of apoptotic process

Inferred from electronic annotation. Source: Ensembl

neuron migration

Inferred from electronic annotation. Source: Ensembl

positive regulation of auditory receptor cell differentiation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Inferred from sequence or structural similarity. Source: UniProtKB

positive regulation of transcription from RNA polymerase II promoter

Inferred from electronic annotation. Source: Ensembl

transcription from RNA polymerase II promoter

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentnucleus

Inferred from sequence or structural similarity. Source: UniProtKB

   Molecular_functionchromatin DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding

Inferred from electronic annotation. Source: Ensembl

sequence-specific DNA binding transcription factor activity

Traceable author statement Ref.1. Source: ProtInc

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Protein atonal homolog 1
PRO_0000127139

Regions

Domain159 – 21153bHLH
Compositional bias29 – 3810Poly-Pro
Compositional bias224 – 2285Poly-Pro

Natural variations

Natural variant2371H → Q.
Corresponds to variant rs35182771 [ dbSNP | Ensembl ].
VAR_049539

Sequences

Sequence LengthMass (Da)Tools
Q92858 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: AB12F1E917A00A8D

FASTA35438,160
        10         20         30         40         50         60 
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD 

        70         80         90        100        110        120 
PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG 

       130        140        150        160        170        180 
PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD 

       190        200        210        220        230        240 
QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT 

       250        260        270        280        290        300 
AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS 

       310        320        330        340        350 
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS 

« Hide

References

« Hide 'large scale' references
[1]"Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis."
Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y.
Hum. Mol. Genet. 5:1207-1216(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U61148 Genomic DNA. Translation: AAB41305.1.
BC069145 mRNA. Translation: AAH69145.1.
BC069594 mRNA. Translation: AAH69594.1.
BC069604 mRNA. Translation: AAH69604.1.
BC113623 mRNA. Translation: AAI13624.1.
BC113625 mRNA. Translation: AAI13626.1.
RefSeqNP_005163.1. NM_005172.1.
UniGeneHs.532680.

3D structure databases

ProteinModelPortalQ92858.
SMRQ92858. Positions 160-216.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING9606.ENSP00000302216.

PTM databases

PhosphoSiteQ92858.

Polymorphism databases

DMDM3913115.

Proteomic databases

PaxDbQ92858.
PRIDEQ92858.

Protocols and materials databases

DNASU474.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000306011; ENSP00000302216; ENSG00000172238.
GeneID474.
KEGGhsa:474.
UCSCuc003hta.1. human.

Organism-specific databases

CTD474.
GeneCardsGC04P094750.
HGNCHGNC:797. ATOH1.
MIM601461. gene.
neXtProtNX_Q92858.
PharmGKBPA25095.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG267878.
HOGENOMHOG000261611.
HOVERGENHBG050609.
InParanoidQ92858.
KOK09083.
OMAHSHYSDS.
OrthoDBEOG7PGDSD.
PhylomeDBQ92858.
TreeFamTF315153.

Gene expression databases

ArrayExpressQ92858.
BgeeQ92858.
CleanExHS_ATOH1.
GenevestigatorQ92858.

Family and domain databases

Gene3D4.10.280.10. 1 hit.
InterProIPR011598. bHLH_dom.
[Graphical view]
PfamPF00010. HLH. 1 hit.
[Graphical view]
SMARTSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMSSF47459. SSF47459. 1 hit.
PROSITEPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GeneWikiATOH1.
GenomeRNAi474.
NextBio1963.
PROQ92858.
SOURCESearch...

Entry information

Entry nameATOH1_HUMAN
AccessionPrimary (citable) accession number: Q92858
Secondary accession number(s): Q14CT9
Entry history
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: February 19, 2014
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 4

Human chromosome 4: entries, gene names and cross-references to MIM