Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q92858

- ATOH1_HUMAN

UniProt

Q92858 - ATOH1_HUMAN

Protein

Protein atonal homolog 1

Gene

ATOH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription By similarity.By similarity

    GO - Molecular functioni

    1. chromatin DNA binding Source: Ensembl
    2. sequence-specific DNA binding Source: Ensembl
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. auditory receptor cell fate determination Source: Ensembl
    2. auditory receptor cell fate specification Source: Ensembl
    3. axon guidance Source: Ensembl
    4. central nervous system development Source: ProtInc
    5. cerebral cortex development Source: Ensembl
    6. inner ear morphogenesis Source: Ensembl
    7. negative regulation of apoptotic process Source: Ensembl
    8. neuron migration Source: Ensembl
    9. positive regulation of auditory receptor cell differentiation Source: Ensembl
    10. positive regulation of neuron differentiation Source: UniProtKB
    11. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    12. transcription from RNA polymerase II promoter Source: ProtInc

    Keywords - Molecular functioni

    Activator, Developmental protein

    Keywords - Biological processi

    Differentiation, Neurogenesis, Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein atonal homolog 1
    Alternative name(s):
    Class A basic helix-loop-helix protein 14
    Short name:
    bHLHa14
    Helix-loop-helix protein hATH-1
    Short name:
    hATH1
    Gene namesi
    Name:ATOH1
    Synonyms:ATH1, BHLHA14
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:797. ATOH1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25095.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Protein atonal homolog 1PRO_0000127139Add
    BLAST

    Proteomic databases

    PaxDbiQ92858.
    PRIDEiQ92858.

    PTM databases

    PhosphoSiteiQ92858.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92858.
    BgeeiQ92858.
    CleanExiHS_ATOH1.
    GenevestigatoriQ92858.

    Interactioni

    Subunit structurei

    Efficient DNA binding requires dimerization with another bHLH protein.

    Protein-protein interaction databases

    STRINGi9606.ENSP00000302216.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92858.
    SMRiQ92858. Positions 160-216.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini159 – 21153bHLHPROSITE-ProRule annotationAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi29 – 3810Poly-Pro
    Compositional biasi224 – 2285Poly-Pro

    Sequence similaritiesi

    Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG267878.
    HOGENOMiHOG000261611.
    HOVERGENiHBG050609.
    InParanoidiQ92858.
    KOiK09083.
    OMAiHSHYSDS.
    OrthoDBiEOG7PGDSD.
    PhylomeDBiQ92858.
    TreeFamiTF315153.

    Family and domain databases

    Gene3Di4.10.280.10. 1 hit.
    InterProiIPR011598. bHLH_dom.
    [Graphical view]
    PfamiPF00010. HLH. 1 hit.
    [Graphical view]
    SMARTiSM00353. HLH. 1 hit.
    [Graphical view]
    SUPFAMiSSF47459. SSF47459. 1 hit.
    PROSITEiPS50888. BHLH. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92858-1 [UniParc]FASTAAdd to Basket

    « Hide

    MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP    50
    PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD 100
    GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS 150
    KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET 200
    LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN 250
    ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS 300
    ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS 350
    DEAS 354
    Length:354
    Mass (Da):38,160
    Last modified:February 1, 1997 - v1
    Checksum:iAB12F1E917A00A8D
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti237 – 2371H → Q.
    Corresponds to variant rs35182771 [ dbSNP | Ensembl ].
    VAR_049539

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61148 Genomic DNA. Translation: AAB41305.1.
    BC069145 mRNA. Translation: AAH69145.1.
    BC069594 mRNA. Translation: AAH69594.1.
    BC069604 mRNA. Translation: AAH69604.1.
    BC113623 mRNA. Translation: AAI13624.1.
    BC113625 mRNA. Translation: AAI13626.1.
    CCDSiCCDS3638.1.
    RefSeqiNP_005163.1. NM_005172.1.
    UniGeneiHs.532680.

    Genome annotation databases

    EnsembliENST00000306011; ENSP00000302216; ENSG00000172238.
    GeneIDi474.
    KEGGihsa:474.
    UCSCiuc003hta.1. human.

    Polymorphism databases

    DMDMi3913115.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U61148 Genomic DNA. Translation: AAB41305.1 .
    BC069145 mRNA. Translation: AAH69145.1 .
    BC069594 mRNA. Translation: AAH69594.1 .
    BC069604 mRNA. Translation: AAH69604.1 .
    BC113623 mRNA. Translation: AAI13624.1 .
    BC113625 mRNA. Translation: AAI13626.1 .
    CCDSi CCDS3638.1.
    RefSeqi NP_005163.1. NM_005172.1.
    UniGenei Hs.532680.

    3D structure databases

    ProteinModelPortali Q92858.
    SMRi Q92858. Positions 160-216.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 9606.ENSP00000302216.

    PTM databases

    PhosphoSitei Q92858.

    Polymorphism databases

    DMDMi 3913115.

    Proteomic databases

    PaxDbi Q92858.
    PRIDEi Q92858.

    Protocols and materials databases

    DNASUi 474.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000306011 ; ENSP00000302216 ; ENSG00000172238 .
    GeneIDi 474.
    KEGGi hsa:474.
    UCSCi uc003hta.1. human.

    Organism-specific databases

    CTDi 474.
    GeneCardsi GC04P094750.
    HGNCi HGNC:797. ATOH1.
    MIMi 601461. gene.
    neXtProti NX_Q92858.
    PharmGKBi PA25095.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG267878.
    HOGENOMi HOG000261611.
    HOVERGENi HBG050609.
    InParanoidi Q92858.
    KOi K09083.
    OMAi HSHYSDS.
    OrthoDBi EOG7PGDSD.
    PhylomeDBi Q92858.
    TreeFami TF315153.

    Miscellaneous databases

    GeneWikii ATOH1.
    GenomeRNAii 474.
    NextBioi 1963.
    PROi Q92858.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92858.
    Bgeei Q92858.
    CleanExi HS_ATOH1.
    Genevestigatori Q92858.

    Family and domain databases

    Gene3Di 4.10.280.10. 1 hit.
    InterProi IPR011598. bHLH_dom.
    [Graphical view ]
    Pfami PF00010. HLH. 1 hit.
    [Graphical view ]
    SMARTi SM00353. HLH. 1 hit.
    [Graphical view ]
    SUPFAMi SSF47459. SSF47459. 1 hit.
    PROSITEi PS50888. BHLH. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis."
      Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y.
      Hum. Mol. Genet. 5:1207-1216(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiATOH1_HUMAN
    AccessioniPrimary (citable) accession number: Q92858
    Secondary accession number(s): Q14CT9
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3