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Q92858

- ATOH1_HUMAN

UniProt

Q92858 - ATOH1_HUMAN

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Protein

Protein atonal homolog 1

Gene

ATOH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).By similarity

GO - Molecular functioni

  1. chromatin DNA binding Source: Ensembl
  2. RNA polymerase II core promoter proximal region sequence-specific DNA binding Source: Ensembl
  3. RNA polymerase II core promoter proximal region sequence-specific DNA binding transcription factor activity involved in positive regulation of transcription Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: ProtInc

GO - Biological processi

  1. auditory receptor cell fate determination Source: Ensembl
  2. auditory receptor cell fate specification Source: Ensembl
  3. axon guidance Source: Ensembl
  4. central nervous system development Source: ProtInc
  5. cerebral cortex development Source: Ensembl
  6. inner ear morphogenesis Source: Ensembl
  7. negative regulation of apoptotic process Source: Ensembl
  8. neuron migration Source: Ensembl
  9. positive regulation of auditory receptor cell differentiation Source: Ensembl
  10. positive regulation of neuron differentiation Source: UniProtKB
  11. transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 1
Alternative name(s):
Class A basic helix-loop-helix protein 14
Short name:
bHLHa14
Helix-loop-helix protein hATH-1
Short name:
hATH1
Gene namesi
Name:ATOH1
Synonyms:ATH1, BHLHA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:797. ATOH1.

Subcellular locationi

Nucleus Curated

GO - Cellular componenti

  1. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA25095.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Protein atonal homolog 1PRO_0000127139Add
BLAST

Proteomic databases

PaxDbiQ92858.
PRIDEiQ92858.

PTM databases

PhosphoSiteiQ92858.

Expressioni

Gene expression databases

BgeeiQ92858.
CleanExiHS_ATOH1.
ExpressionAtlasiQ92858. baseline and differential.
GenevestigatoriQ92858.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi9606.ENSP00000302216.

Structurei

3D structure databases

ProteinModelPortaliQ92858.
SMRiQ92858. Positions 160-216.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini159 – 21153bHLHPROSITE-ProRule annotationAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi29 – 3810Poly-Pro
Compositional biasi224 – 2285Poly-Pro

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG267878.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000261611.
HOVERGENiHBG050609.
InParanoidiQ92858.
KOiK09083.
OMAiHSHYSDS.
OrthoDBiEOG7PGDSD.
PhylomeDBiQ92858.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR011598. bHLH_dom.
[Graphical view]
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92858-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP
60 70 80 90 100
PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD
110 120 130 140 150
GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS
160 170 180 190 200
KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET
210 220 230 240 250
LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN
260 270 280 290 300
ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS
310 320 330 340 350
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS

DEAS
Length:354
Mass (Da):38,160
Last modified:February 1, 1997 - v1
Checksum:iAB12F1E917A00A8D
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti237 – 2371H → Q.
Corresponds to variant rs35182771 [ dbSNP | Ensembl ].
VAR_049539

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61148 Genomic DNA. Translation: AAB41305.1.
BC069145 mRNA. Translation: AAH69145.1.
BC069594 mRNA. Translation: AAH69594.1.
BC069604 mRNA. Translation: AAH69604.1.
BC113623 mRNA. Translation: AAI13624.1.
BC113625 mRNA. Translation: AAI13626.1.
CCDSiCCDS3638.1.
RefSeqiNP_005163.1. NM_005172.1.
UniGeneiHs.532680.

Genome annotation databases

EnsembliENST00000306011; ENSP00000302216; ENSG00000172238.
GeneIDi474.
KEGGihsa:474.
UCSCiuc003hta.1. human.

Polymorphism databases

DMDMi3913115.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U61148 Genomic DNA. Translation: AAB41305.1 .
BC069145 mRNA. Translation: AAH69145.1 .
BC069594 mRNA. Translation: AAH69594.1 .
BC069604 mRNA. Translation: AAH69604.1 .
BC113623 mRNA. Translation: AAI13624.1 .
BC113625 mRNA. Translation: AAI13626.1 .
CCDSi CCDS3638.1.
RefSeqi NP_005163.1. NM_005172.1.
UniGenei Hs.532680.

3D structure databases

ProteinModelPortali Q92858.
SMRi Q92858. Positions 160-216.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 9606.ENSP00000302216.

PTM databases

PhosphoSitei Q92858.

Polymorphism databases

DMDMi 3913115.

Proteomic databases

PaxDbi Q92858.
PRIDEi Q92858.

Protocols and materials databases

DNASUi 474.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000306011 ; ENSP00000302216 ; ENSG00000172238 .
GeneIDi 474.
KEGGi hsa:474.
UCSCi uc003hta.1. human.

Organism-specific databases

CTDi 474.
GeneCardsi GC04P094750.
HGNCi HGNC:797. ATOH1.
MIMi 601461. gene.
neXtProti NX_Q92858.
PharmGKBi PA25095.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG267878.
GeneTreei ENSGT00680000099860.
HOGENOMi HOG000261611.
HOVERGENi HBG050609.
InParanoidi Q92858.
KOi K09083.
OMAi HSHYSDS.
OrthoDBi EOG7PGDSD.
PhylomeDBi Q92858.
TreeFami TF315153.

Miscellaneous databases

GeneWikii ATOH1.
GenomeRNAii 474.
NextBioi 1963.
PROi Q92858.
SOURCEi Search...

Gene expression databases

Bgeei Q92858.
CleanExi HS_ATOH1.
ExpressionAtlasi Q92858. baseline and differential.
Genevestigatori Q92858.

Family and domain databases

Gene3Di 4.10.280.10. 1 hit.
InterProi IPR011598. bHLH_dom.
[Graphical view ]
Pfami PF00010. HLH. 1 hit.
[Graphical view ]
SMARTi SM00353. HLH. 1 hit.
[Graphical view ]
SUPFAMi SSF47459. SSF47459. 1 hit.
PROSITEi PS50888. BHLH. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis."
    Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y.
    Hum. Mol. Genet. 5:1207-1216(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiATOH1_HUMAN
AccessioniPrimary (citable) accession number: Q92858
Secondary accession number(s): Q14CT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: October 29, 2014
This is version 120 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3