Reviewed, UniProtKB/Swiss-Prot Q92858 (ATOH1_HUMAN)

Names and origin

Protein names

Recommended name:
    Protein atonal homolog 1
Alternative name(s):
    Helix-loop-helix protein hATH-1

Gene names

Name:	ATOH1
Synonyms:	ATH1

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	354 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. May play a role in the differentiation of subsets of neural cells by activating E box-dependent transcription By similarity.
Subunit structure	Efficient DNA binding requires dimerization with another bHLH protein.
Subcellular location	Nucleus Probable.
Sequence similarities	Contains 1 basic helix-loop-helix (bHLH) domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Ligand	DNA-binding
Molecular function	Activator
Gene Ontology (GO)
Biological process	transcription from RNA polymerase II promoter Ref.1 Traceable author statement. Source: ProtInc
Cellular component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	transcription factor activity Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 354	354	Protein atonal homolog 1		PRO_0000127139
Regions
	Domain	172 – 212	41	Helix-loop-helix motif
	DNA binding	160 – 171	12	Basic motif
	Compositional bias	29 – 38	10	Poly-Pro
	Compositional bias	224 – 228	5	Poly-Pro
Natural variations
	Natural variant	237	1	H → Q: dbSNP rs35182771.		VAR_049539

Sequences

	Sequence		Length	Mass (Da)
	Q92858-1 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: AB12F1E917A00A8D	FASTA	354	38,160
	10 20 30 40 50 60 MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP PELSLLDSTD 70 80 90 100 110 120 PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD GRGELVRRSS GGASSSKSPG 130 140 150 160 170 180 PVKVREQLCK LKGGVVVDEL GCSRQRAPSS KQVNGVQKQR RLAANARERR RMHGLNHAFD 190 200 210 220 230 240 QLRNVIPSFN NDKKLSKYET LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT 250 260 270 280 290 300 AASYEGGAGN ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS 310 320 330 340 350 ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS DEAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Evolutionary conservation of sequence and expression of the bHLH protein Atonal suggests a conserved role in neurogenesis." Ben-Arie N., McCall A.E., Berkman S., Eichele G., Bellen H.J., Zoghbi H.Y. Hum. Mol. Genet. 5:1207-1216(1996) [PubMed: 8872459] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	U61148 Genomic DNA. Translation: AAB41305.1. BC069145 mRNA. Translation: AAH69145.1. BC069594 mRNA. Translation: AAH69594.1. BC069604 mRNA. Translation: AAH69604.1. BC113623 mRNA. Translation: AAI13624.1. BC113625 mRNA. Translation: AAI13626.1.
IPI	IPI00023811.
RefSeq	NP_005163.1.
UniGene	Hs.532680
3D structure databases
ModBase	Search...
PTM databases
PhosphoSite	Q92858.
Proteomic databases
PRIDE	Q92858.
Genome annotation databases
Ensembl	ENSG00000172238. Homo sapiens. [Contig view]
GeneID	474.
KEGG	hsa:474.
Organism-specific databases
GeneCards	GC04P095051.
HGNC	HGNC:797. ATOH1.
MIM	601461. gene.
PharmGKB	PA25095.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q92858.
HOVERGEN	Q92858.
OMA	Q92858. PSSKQVN.
Gene expression databases
ArrayExpress	Q92858.
Bgee	Q92858.
CleanEx	HS_ATOH1.
GermOnline	ENSG00000172238. Homo sapiens.
Family and domain databases
InterPro	IPR001092. HLH_basic. IPR011598. HLH_DNA_bd. [Graphical view]
Gene3D	G3DSA:4.10.280.10. HLH_DNA_bd. 1 hit.
Pfam	PF00010. HLH. 1 hit. [Graphical view]
SMART	SM00353. HLH. 1 hit. [Graphical view]
PROSITE	PS50888. HLH. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	1963.
SOURCE	Search...

Entry information

Entry name

ATOH1_HUMAN

Accession

Primary (citable) accession number: Q92858
Secondary accession number(s): Q14CT9

Entry history

Integrated into UniProtKB/Swiss-Prot:	December 15, 1998
Last sequence update:	February 1, 1997
Last modified:	June 16, 2009
This is version 71 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)