Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Protein atonal homolog 1

Gene

ATOH1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Transcriptional regulator. Activates E box-dependent transcription in collaboration with TCF3/E47, but the activity is completely antagonized by the negative regulator of neurogenesis HES1. Plays a role in the differentiation of subsets of neural cells by activating E box-dependent transcription (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Differentiation, Neurogenesis, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172238-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein atonal homolog 1
Alternative name(s):
Class A basic helix-loop-helix protein 14
Short name:
bHLHa14
Helix-loop-helix protein hATH-1
Short name:
hATH1
Gene namesi
Name:ATOH1
Synonyms:ATH1, BHLHA14
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:797. ATOH1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi474.
OpenTargetsiENSG00000172238.
PharmGKBiPA25095.

Polymorphism and mutation databases

BioMutaiATOH1.
DMDMi3913115.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001271391 – 354Protein atonal homolog 1Add BLAST354

Proteomic databases

PaxDbiQ92858.
PeptideAtlasiQ92858.
PRIDEiQ92858.

PTM databases

iPTMnetiQ92858.
PhosphoSitePlusiQ92858.

Expressioni

Gene expression databases

BgeeiENSG00000172238.
CleanExiHS_ATOH1.
GenevisibleiQ92858. HS.

Interactioni

Subunit structurei

Efficient DNA binding requires dimerization with another bHLH protein.

Protein-protein interaction databases

STRINGi9606.ENSP00000302216.

Structurei

3D structure databases

ProteinModelPortaliQ92858.
SMRiQ92858.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini159 – 211bHLHPROSITE-ProRule annotationAdd BLAST53

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi29 – 38Poly-Pro10
Compositional biasi224 – 228Poly-Pro5

Sequence similaritiesi

Contains 1 bHLH (basic helix-loop-helix) domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000261611.
HOVERGENiHBG050609.
InParanoidiQ92858.
KOiK09083.
OMAiLHAEEWA.
OrthoDBiEOG091G0R1N.
PhylomeDBiQ92858.
TreeFamiTF315153.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032661. ATOH1.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF82. PTHR19290:SF82. 2 hits.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92858-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSRLLHAEEW AEVKELGDHH RQPQPHHLPQ PPPPPQPPAT LQAREHPVYP
60 70 80 90 100
PELSLLDSTD PRAWLAPTLQ GICTARAAQY LLHSPELGAS EAAAPRDEVD
110 120 130 140 150
GRGELVRRSS GGASSSKSPG PVKVREQLCK LKGGVVVDEL GCSRQRAPSS
160 170 180 190 200
KQVNGVQKQR RLAANARERR RMHGLNHAFD QLRNVIPSFN NDKKLSKYET
210 220 230 240 250
LQMAQIYINA LSELLQTPSG GEQPPPPPAS CKSDHHHLRT AASYEGGAGN
260 270 280 290 300
ATAAGAQQAS GGSQRPTPPG SCRTRFSAPA SAGGYSVQLD ALHFSTFEDS
310 320 330 340 350
ALTAMMAQKN LSPSLPGSIL QPVQEENSKT SPRSHRSDGE FSPHSHYSDS

DEAS
Length:354
Mass (Da):38,160
Last modified:February 1, 1997 - v1
Checksum:iAB12F1E917A00A8D
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_049539237H → Q.Corresponds to variant rs35182771dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61148 Genomic DNA. Translation: AAB41305.1.
BC069145 mRNA. Translation: AAH69145.1.
BC069594 mRNA. Translation: AAH69594.1.
BC069604 mRNA. Translation: AAH69604.1.
BC113623 mRNA. Translation: AAI13624.1.
BC113625 mRNA. Translation: AAI13626.1.
CCDSiCCDS3638.1.
RefSeqiNP_005163.1. NM_005172.1.
UniGeneiHs.532680.

Genome annotation databases

EnsembliENST00000306011; ENSP00000302216; ENSG00000172238.
GeneIDi474.
KEGGihsa:474.
UCSCiuc003hta.2. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U61148 Genomic DNA. Translation: AAB41305.1.
BC069145 mRNA. Translation: AAH69145.1.
BC069594 mRNA. Translation: AAH69594.1.
BC069604 mRNA. Translation: AAH69604.1.
BC113623 mRNA. Translation: AAI13624.1.
BC113625 mRNA. Translation: AAI13626.1.
CCDSiCCDS3638.1.
RefSeqiNP_005163.1. NM_005172.1.
UniGeneiHs.532680.

3D structure databases

ProteinModelPortaliQ92858.
SMRiQ92858.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000302216.

PTM databases

iPTMnetiQ92858.
PhosphoSitePlusiQ92858.

Polymorphism and mutation databases

BioMutaiATOH1.
DMDMi3913115.

Proteomic databases

PaxDbiQ92858.
PeptideAtlasiQ92858.
PRIDEiQ92858.

Protocols and materials databases

DNASUi474.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000306011; ENSP00000302216; ENSG00000172238.
GeneIDi474.
KEGGihsa:474.
UCSCiuc003hta.2. human.

Organism-specific databases

CTDi474.
DisGeNETi474.
GeneCardsiATOH1.
HGNCiHGNC:797. ATOH1.
MIMi601461. gene.
neXtProtiNX_Q92858.
OpenTargetsiENSG00000172238.
PharmGKBiPA25095.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4395. Eukaryota.
ENOG411269K. LUCA.
GeneTreeiENSGT00680000099860.
HOGENOMiHOG000261611.
HOVERGENiHBG050609.
InParanoidiQ92858.
KOiK09083.
OMAiLHAEEWA.
OrthoDBiEOG091G0R1N.
PhylomeDBiQ92858.
TreeFamiTF315153.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172238-MONOMER.

Miscellaneous databases

GeneWikiiATOH1.
GenomeRNAii474.
PROiQ92858.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172238.
CleanExiHS_ATOH1.
GenevisibleiQ92858. HS.

Family and domain databases

Gene3Di4.10.280.10. 1 hit.
InterProiIPR032661. ATOH1.
IPR011598. bHLH_dom.
[Graphical view]
PANTHERiPTHR19290:SF82. PTHR19290:SF82. 2 hits.
PfamiPF00010. HLH. 1 hit.
[Graphical view]
SMARTiSM00353. HLH. 1 hit.
[Graphical view]
SUPFAMiSSF47459. SSF47459. 1 hit.
PROSITEiPS50888. BHLH. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiATOH1_HUMAN
AccessioniPrimary (citable) accession number: Q92858
Secondary accession number(s): Q14CT9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 15, 1998
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 133 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.