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Protein

Semaphorin-4D

Gene

SEMA4D

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor for PLXN1B and PLXNB2 that plays an important role in cell-cell signaling. Promotes reorganization of the actin cytoskeleton and plays a role in axonal growth cone guidance in the developing central nervous system. Regulates dendrite and axon branching and morphogenesis. Promotes the migration of cerebellar granule cells and of endothelial cells. Plays a role in the immune system; induces B-cells to aggregate and improves their viability (in vitro). Promotes signaling via SRC and PTK2B/PYK2, which then mediates activation of phosphatidylinositol 3-kinase and of the AKT1 signaling cascade. Interaction with PLXNB1 mediates activation of RHOA.4 Publications

GO - Molecular functioni

  • chemorepellent activity Source: GO_Central
  • receptor activity Source: HGNC
  • receptor binding Source: UniProtKB
  • semaphorin receptor binding Source: UniProtKB
  • transmembrane signaling receptor activity Source: UniProtKB

GO - Biological processi

  • cell adhesion Source: ProtInc
  • immune response Source: ProtInc
  • leukocyte aggregation Source: UniProtKB
  • negative chemotaxis Source: GO_Central
  • negative regulation of alkaline phosphatase activity Source: BHF-UCL
  • negative regulation of apoptotic process Source: ProtInc
  • negative regulation of axon extension involved in axon guidance Source: GO_Central
  • negative regulation of cell adhesion Source: UniProtKB
  • negative regulation of osteoblast differentiation Source: BHF-UCL
  • negative regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • neural crest cell migration Source: GO_Central
  • ossification involved in bone maturation Source: BHF-UCL
  • positive regulation of cell migration Source: UniProtKB
  • positive regulation of collateral sprouting Source: UniProtKB
  • positive regulation of GTPase activity Source: UniProtKB
  • positive regulation of peptidyl-tyrosine phosphorylation Source: BHF-UCL
  • positive regulation of phosphatidylinositol 3-kinase signaling Source: UniProtKB
  • positive regulation of protein phosphorylation Source: UniProtKB
  • regulation of cell projection organization Source: UniProtKB
  • regulation of cell shape Source: UniProtKB
  • regulation of dendrite morphogenesis Source: UniProtKB
  • semaphorin-plexin signaling pathway Source: UniProtKB
  • semaphorin-plexin signaling pathway involved in bone trabecula morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Receptor

Keywords - Biological processi

Differentiation, Neurogenesis

Enzyme and pathway databases

BioCyciZFISH:G66-31596-MONOMER.
ReactomeiR-HSA-416550. Sema4D mediated inhibition of cell attachment and migration.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-416700. Other semaphorin interactions.
SIGNORiQ92854.

Names & Taxonomyi

Protein namesi
Recommended name:
Semaphorin-4D
Alternative name(s):
A8
BB18
GR3
CD_antigen: CD100
Gene namesi
Name:SEMA4D
Synonyms:C9orf164, CD100, SEMAJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10732. SEMA4D.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini22 – 734ExtracellularSequence analysisAdd BLAST713
Transmembranei735 – 755HelicalSequence analysisAdd BLAST21
Topological domaini756 – 862CytoplasmicSequence analysisAdd BLAST107

GO - Cellular componenti

  • extracellular space Source: BHF-UCL
  • integral component of plasma membrane Source: UniProtKB
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi100 – 101KG → DT: Abolishes PLXNB1 binding. 1 Publication2
Mutagenesisi181 – 182FL → ER: Abolishes PLXNB1 binding. 1 Publication2
Mutagenesisi244F → N: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with S-246. 1 Publication1
Mutagenesisi246F → S: Abolishes homodimerization, abolishes collapse of growth cones and reduces PLXNB1 binding; when associated with N-244. 1 Publication1
Mutagenesisi395K → E: Strongly reduces PLXNB1 binding. 1 Publication1

Organism-specific databases

DisGeNETi10507.
OpenTargetsiENSG00000187764.
PharmGKBiPA35654.

Chemistry databases

GuidetoPHARMACOLOGYi2883.

Polymorphism and mutation databases

BioMutaiSEMA4D.
DMDMi8134701.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
ChainiPRO_000003232722 – 862Semaphorin-4DAdd BLAST841

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi49N-linked (GlcNAc...)2 Publications1
Glycosylationi74N-linked (GlcNAc...); atypical1 Publication1
Glycosylationi77N-linked (GlcNAc...)2 Publications1
Disulfide bondi97 ↔ 108
Disulfide bondi126 ↔ 135
Glycosylationi139N-linked (GlcNAc...)1 Publication1
Glycosylationi191N-linked (GlcNAc...)1 Publication1
Disulfide bondi257 ↔ 370
Disulfide bondi281 ↔ 326
Glycosylationi329N-linked (GlcNAc...)1 Publication1
Glycosylationi379N-linked (GlcNAc...)1 Publication1
Glycosylationi419N-linked (GlcNAc...)3 Publications1
Disulfide bondi503 ↔ 520
Disulfide bondi509 ↔ 553
Disulfide bondi512 ↔ 529
Disulfide bondi576 ↔ 624
Glycosylationi613N-linked (GlcNAc...)Sequence analysis1
Glycosylationi632N-linked (GlcNAc...)Sequence analysis1
Modified residuei833PhosphoserineCombined sources1

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ92854.
MaxQBiQ92854.
PaxDbiQ92854.
PeptideAtlasiQ92854.
PRIDEiQ92854.

PTM databases

iPTMnetiQ92854.
PhosphoSitePlusiQ92854.
SwissPalmiQ92854.

Expressioni

Tissue specificityi

Strongly expressed in skeletal muscle, peripheral blood lymphocytes, spleen, and thymus and also expressed at lower levels in testes, brain, kidney, small intestine, prostate, heart, placenta, lung and pancreas, but not in colon and liver.1 Publication

Gene expression databases

BgeeiENSG00000187764.
CleanExiHS_SEMA4D.
ExpressionAtlasiQ92854. baseline and differential.
GenevisibleiQ92854. HS.

Organism-specific databases

HPAiHPA015662.
HPA023277.

Interactioni

Subunit structurei

Homodimer. Interacts with PLXNB2 (By similarity). Binds PLXNB1.By similarity2 Publications

GO - Molecular functioni

  • receptor binding Source: UniProtKB
  • semaphorin receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115766. 10 interactors.
DIPiDIP-59221N.
IntActiQ92854. 3 interactors.
STRINGi9606.ENSP00000348822.

Structurei

Secondary structure

1862
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi29 – 32Combined sources4
Turni34 – 36Combined sources3
Beta strandi40 – 42Combined sources3
Beta strandi52 – 55Combined sources4
Beta strandi59 – 65Combined sources7
Beta strandi67 – 74Combined sources8
Beta strandi77 – 86Combined sources10
Helixi91 – 99Combined sources9
Turni104 – 107Combined sources4
Beta strandi111 – 117Combined sources7
Beta strandi119 – 127Combined sources9
Turni129 – 131Combined sources3
Beta strandi134 – 139Combined sources6
Turni140 – 143Combined sources4
Turni153 – 155Combined sources3
Beta strandi164 – 169Combined sources6
Beta strandi172 – 180Combined sources9
Beta strandi185 – 191Combined sources7
Beta strandi193 – 195Combined sources3
Turni203 – 205Combined sources3
Beta strandi210 – 217Combined sources8
Beta strandi230 – 238Combined sources9
Beta strandi249 – 257Combined sources9
Beta strandi264 – 267Combined sources4
Beta strandi275 – 279Combined sources5
Helixi284 – 286Combined sources3
Beta strandi292 – 299Combined sources8
Beta strandi308 – 314Combined sources7
Beta strandi316 – 318Combined sources3
Beta strandi320 – 329Combined sources10
Helixi330 – 339Combined sources10
Beta strandi342 – 346Combined sources5
Turni349 – 351Combined sources3
Beta strandi354 – 357Combined sources4
Helixi373 – 376Combined sources4
Turni377 – 379Combined sources3
Helixi383 – 385Combined sources3
Helixi388 – 396Combined sources9
Beta strandi399 – 404Combined sources6
Helixi407 – 409Combined sources3
Beta strandi412 – 417Combined sources6
Beta strandi420 – 429Combined sources10
Beta strandi431 – 433Combined sources3
Beta strandi435 – 443Combined sources9
Beta strandi446 – 453Combined sources8
Beta strandi455 – 465Combined sources11
Beta strandi475 – 478Combined sources4
Beta strandi481 – 484Combined sources4
Beta strandi486 – 490Combined sources5
Beta strandi495 – 500Combined sources6
Helixi503 – 505Combined sources3
Helixi509 – 514Combined sources6
Beta strandi520 – 523Combined sources4
Turni524 – 527Combined sources4
Beta strandi528 – 531Combined sources4
Turni532 – 534Combined sources3
Helixi539 – 541Combined sources3
Helixi550 – 552Combined sources3
Beta strandi553 – 555Combined sources3
Beta strandi560 – 567Combined sources8
Beta strandi572 – 574Combined sources3
Beta strandi584 – 593Combined sources10
Beta strandi598 – 602Combined sources5
Turni604 – 607Combined sources4
Beta strandi609 – 611Combined sources3
Helixi616 – 618Combined sources3
Beta strandi620 – 629Combined sources10
Beta strandi631 – 647Combined sources17

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLZX-ray2.00A/B22-677[»]
3OL2X-ray2.99A22-677[»]
ProteinModelPortaliQ92854.
SMRiQ92854.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92854.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini22 – 500SemaPROSITE-ProRule annotationAdd BLAST479
Domaini502 – 551PSIAdd BLAST50
Domaini554 – 636Ig-like C2-typeAdd BLAST83

Sequence similaritiesi

Belongs to the semaphorin family.Curated
Contains 1 PSI domain.Curated
Contains 1 Sema domain.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000111669.
HOVERGENiHBG061627.
InParanoidiQ92854.
KOiK06521.
OMAiQAQHVHA.
OrthoDBiEOG091G01W0.
PhylomeDBiQ92854.
TreeFamiTF316102.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92854-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRMCTPIRGL LMALAVMFGT AMAFAPIPRI TWEHREVHLV QFHEPDIYNY
60 70 80 90 100
SALLLSEDKD TLYIGAREAV FAVNALNISE KQHEVYWKVS EDKKAKCAEK
110 120 130 140 150
GKSKQTECLN YIRVLQPLSA TSLYVCGTNA FQPACDHLNL TSFKFLGKNE
160 170 180 190 200
DGKGRCPFDP AHSYTSVMVD GELYSGTSYN FLGSEPIISR NSSHSPLRTE
210 220 230 240 250
YAIPWLNEPS FVFADVIRKS PDSPDGEDDR VYFFFTEVSV EYEFVFRVLI
260 270 280 290 300
PRIARVCKGD QGGLRTLQKK WTSFLKARLI CSRPDSGLVF NVLRDVFVLR
310 320 330 340 350
SPGLKVPVFY ALFTPQLNNV GLSAVCAYNL STAEEVFSHG KYMQSTTVEQ
360 370 380 390 400
SHTKWVRYNG PVPKPRPGAC IDSEARAANY TSSLNLPDKT LQFVKDHPLM
410 420 430 440 450
DDSVTPIDNR PRLIKKDVNY TQIVVDRTQA LDGTVYDVMF VSTDRGALHK
460 470 480 490 500
AISLEHAVHI IEETQLFQDF EPVQTLLLSS KKGNRFVYAG SNSGVVQAPL
510 520 530 540 550
AFCGKHGTCE DCVLARDPYC AWSPPTATCV ALHQTESPSR GLIQEMSGDA
560 570 580 590 600
SVCPDKSKGS YRQHFFKHGG TAELKCSQKS NLARVFWKFQ NGVLKAESPK
610 620 630 640 650
YGLMGRKNLL IFNLSEGDSG VYQCLSEERV KNKTVFQVVA KHVLEVKVVP
660 670 680 690 700
KPVVAPTLSV VQTEGSRIAT KVLVASTQGS SPPTPAVQAT SSGAITLPPK
710 720 730 740 750
PAPTGTSCEP KIVINTVPQL HSEKTMYLKS SDNRLLMSLF LFFFVLFLCL
760 770 780 790 800
FFYNCYKGYL PRQCLKFRSA LLIGKKKPKS DFCDREQSLK ETLVEPGSFS
810 820 830 840 850
QQNGEHPKPA LDTGYETEQD TITSKVPTDR EDSQRIDDLS ARDKPFDVKC
860
ELKFADSDAD GD
Length:862
Mass (Da):96,150
Last modified:February 1, 1997 - v1
Checksum:i7B18EFEA98789371
GO
Isoform 2 (identifier: Q92854-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     555-738: DKSKGSYRQH...KSSDNRLLMS → ASSPKPLPPP...AWESCSKDTL
     739-862: Missing.

Show »
Length:738
Mass (Da):82,164
Checksum:i93ED5D62D6A17ED1
GO

Sequence cautioni

The sequence AAI37516 differs from that shown. Cloning artifact.Curated
The sequence AAI37519 differs from that shown. Cloning artifact.Curated
The sequence BAC04938 differs from that shown. Cloning artifact.Curated
The sequence CAI95794 differs from that shown. Reason: Erroneous gene model prediction.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti592G → D in AAH54500 (PubMed:15489334).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03029372A → T.Corresponds to variant rs13284404dbSNPEnsembl.1
Natural variantiVAR_057175327A → T.Corresponds to variant rs11526468dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_039483555 – 738DKSKG…RLLMS → ASSPKPLPPPGSSSLSCLGH VGDRRLSSPWTPWPASGAGP DSSSRVSLLPPFLSDQAQHV HALGNFYLFCQATGPADIRF VWEKNGRALETCVPVQTHAL PDGRAHALSWLQDAIRESAE YRCSVLSSAGNKTSKVQVAV MRPEVTHQERWTRELSAWRA VAGEHDRMMQSWRKAWESCS KDTL in isoform 2. CuratedAdd BLAST184
Alternative sequenceiVSP_039484739 – 862Missing in isoform 2. CuratedAdd BLAST124

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60800 mRNA. Translation: AAC50810.1.
AL590233 Genomic DNA. Translation: CAI17379.2.
AL929575 Genomic DNA. Translation: CAI43250.2.
AL929575 Genomic DNA. Translation: CAI95794.1. Sequence problems.
BC054500 mRNA. Translation: AAH54500.1.
BC137515 mRNA. Translation: AAI37516.1. Sequence problems.
BC137518 mRNA. Translation: AAI37519.1. Sequence problems.
AK097056 mRNA. Translation: BAC04938.1. Sequence problems.
CCDSiCCDS47991.1. [Q92854-2]
CCDS6685.1. [Q92854-1]
RefSeqiNP_001135759.1. NM_001142287.1. [Q92854-2]
NP_006369.3. NM_006378.3. [Q92854-1]
XP_005251711.1. XM_005251654.3. [Q92854-1]
XP_011516425.1. XM_011518123.2. [Q92854-1]
XP_011516426.1. XM_011518124.2. [Q92854-1]
XP_011516427.1. XM_011518125.1. [Q92854-1]
XP_011516429.1. XM_011518127.2. [Q92854-1]
XP_011516430.1. XM_011518128.2. [Q92854-1]
XP_011516431.1. XM_011518129.1. [Q92854-1]
XP_011516432.1. XM_011518130.2. [Q92854-1]
XP_011516433.1. XM_011518131.2. [Q92854-1]
XP_011516435.1. XM_011518133.2. [Q92854-1]
XP_011516436.1. XM_011518134.2. [Q92854-1]
XP_016869682.1. XM_017014193.1. [Q92854-1]
XP_016869683.1. XM_017014194.1. [Q92854-1]
XP_016869684.1. XM_017014195.1. [Q92854-1]
XP_016869685.1. XM_017014196.1. [Q92854-1]
XP_016869686.1. XM_017014197.1. [Q92854-1]
XP_016869687.1. XM_017014198.1. [Q92854-1]
UniGeneiHs.494406.

Genome annotation databases

EnsembliENST00000339861; ENSP00000344923; ENSG00000187764. [Q92854-2]
ENST00000356444; ENSP00000348822; ENSG00000187764. [Q92854-1]
ENST00000420987; ENSP00000391733; ENSG00000187764. [Q92854-2]
ENST00000422704; ENSP00000388768; ENSG00000187764. [Q92854-1]
ENST00000438547; ENSP00000405102; ENSG00000187764. [Q92854-1]
ENST00000450295; ENSP00000416523; ENSG00000187764. [Q92854-1]
ENST00000455551; ENSP00000411981; ENSG00000187764. [Q92854-2]
GeneIDi10507.
KEGGihsa:10507.
UCSCiuc004aqo.2. human. [Q92854-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U60800 mRNA. Translation: AAC50810.1.
AL590233 Genomic DNA. Translation: CAI17379.2.
AL929575 Genomic DNA. Translation: CAI43250.2.
AL929575 Genomic DNA. Translation: CAI95794.1. Sequence problems.
BC054500 mRNA. Translation: AAH54500.1.
BC137515 mRNA. Translation: AAI37516.1. Sequence problems.
BC137518 mRNA. Translation: AAI37519.1. Sequence problems.
AK097056 mRNA. Translation: BAC04938.1. Sequence problems.
CCDSiCCDS47991.1. [Q92854-2]
CCDS6685.1. [Q92854-1]
RefSeqiNP_001135759.1. NM_001142287.1. [Q92854-2]
NP_006369.3. NM_006378.3. [Q92854-1]
XP_005251711.1. XM_005251654.3. [Q92854-1]
XP_011516425.1. XM_011518123.2. [Q92854-1]
XP_011516426.1. XM_011518124.2. [Q92854-1]
XP_011516427.1. XM_011518125.1. [Q92854-1]
XP_011516429.1. XM_011518127.2. [Q92854-1]
XP_011516430.1. XM_011518128.2. [Q92854-1]
XP_011516431.1. XM_011518129.1. [Q92854-1]
XP_011516432.1. XM_011518130.2. [Q92854-1]
XP_011516433.1. XM_011518131.2. [Q92854-1]
XP_011516435.1. XM_011518133.2. [Q92854-1]
XP_011516436.1. XM_011518134.2. [Q92854-1]
XP_016869682.1. XM_017014193.1. [Q92854-1]
XP_016869683.1. XM_017014194.1. [Q92854-1]
XP_016869684.1. XM_017014195.1. [Q92854-1]
XP_016869685.1. XM_017014196.1. [Q92854-1]
XP_016869686.1. XM_017014197.1. [Q92854-1]
XP_016869687.1. XM_017014198.1. [Q92854-1]
UniGeneiHs.494406.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1OLZX-ray2.00A/B22-677[»]
3OL2X-ray2.99A22-677[»]
ProteinModelPortaliQ92854.
SMRiQ92854.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115766. 10 interactors.
DIPiDIP-59221N.
IntActiQ92854. 3 interactors.
STRINGi9606.ENSP00000348822.

Chemistry databases

GuidetoPHARMACOLOGYi2883.

PTM databases

iPTMnetiQ92854.
PhosphoSitePlusiQ92854.
SwissPalmiQ92854.

Polymorphism and mutation databases

BioMutaiSEMA4D.
DMDMi8134701.

Proteomic databases

EPDiQ92854.
MaxQBiQ92854.
PaxDbiQ92854.
PeptideAtlasiQ92854.
PRIDEiQ92854.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000339861; ENSP00000344923; ENSG00000187764. [Q92854-2]
ENST00000356444; ENSP00000348822; ENSG00000187764. [Q92854-1]
ENST00000420987; ENSP00000391733; ENSG00000187764. [Q92854-2]
ENST00000422704; ENSP00000388768; ENSG00000187764. [Q92854-1]
ENST00000438547; ENSP00000405102; ENSG00000187764. [Q92854-1]
ENST00000450295; ENSP00000416523; ENSG00000187764. [Q92854-1]
ENST00000455551; ENSP00000411981; ENSG00000187764. [Q92854-2]
GeneIDi10507.
KEGGihsa:10507.
UCSCiuc004aqo.2. human. [Q92854-1]

Organism-specific databases

CTDi10507.
DisGeNETi10507.
GeneCardsiSEMA4D.
HGNCiHGNC:10732. SEMA4D.
HPAiHPA015662.
HPA023277.
MIMi601866. gene.
neXtProtiNX_Q92854.
OpenTargetsiENSG00000187764.
PharmGKBiPA35654.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3611. Eukaryota.
ENOG410XQZC. LUCA.
GeneTreeiENSGT00760000118854.
HOGENOMiHOG000111669.
HOVERGENiHBG061627.
InParanoidiQ92854.
KOiK06521.
OMAiQAQHVHA.
OrthoDBiEOG091G01W0.
PhylomeDBiQ92854.
TreeFamiTF316102.

Enzyme and pathway databases

BioCyciZFISH:G66-31596-MONOMER.
ReactomeiR-HSA-416550. Sema4D mediated inhibition of cell attachment and migration.
R-HSA-416572. Sema4D induced cell migration and growth-cone collapse.
R-HSA-416700. Other semaphorin interactions.
SIGNORiQ92854.

Miscellaneous databases

ChiTaRSiSEMA4D. human.
EvolutionaryTraceiQ92854.
GeneWikiiSEMA4D.
GenomeRNAii10507.
PROiQ92854.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000187764.
CleanExiHS_SEMA4D.
ExpressionAtlasiQ92854. baseline and differential.
GenevisibleiQ92854. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR013151. Immunoglobulin.
IPR002165. Plexin_repeat.
IPR016201. PSI.
IPR001627. Semap_dom.
IPR027231. Semaphorin.
IPR015943. WD40/YVTN_repeat-like_dom.
[Graphical view]
PANTHERiPTHR11036. PTHR11036. 1 hit.
PfamiPF00047. ig. 1 hit.
PF01437. PSI. 1 hit.
PF01403. Sema. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
SM00408. IGc2. 1 hit.
SM00423. PSI. 1 hit.
SM00630. Sema. 1 hit.
[Graphical view]
SUPFAMiSSF101912. SSF101912. 1 hit.
SSF48726. SSF48726. 1 hit.
PROSITEiPS50835. IG_LIKE. 1 hit.
PS51004. SEMA. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSEM4D_HUMAN
AccessioniPrimary (citable) accession number: Q92854
Secondary accession number(s): B2RPM6, Q7Z5S4, Q8N8B0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 176 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.