Reviewed, UniProtKB/Swiss-Prot Q92851 (CASPA_HUMAN)

Names and origin

Protein names

Recommended name:
    Caspase-10
      Short name=CASP-10
    EC=3.4.22.63
Alternative name(s):
    ICE-like apoptotic protease 4
    Apoptotic protease Mch-4
    FAS-associated death domain protein interleukin-1B-converting enzyme 2
      Short name=FLICE2
Cleaved into the following 2 chains:
    1- Recommended name:
            Caspase-10 subunit p23/17
    2- Recommended name:
            Caspase-10 subunit p12

Gene names

Name:	CASP10
Synonyms:	MCH4

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	521 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Involved in the activation cascade of caspases responsible for apoptosis execution. Recruited to both Fas- and TNFR-1 receptors in a FADD dependent manner. May participate in the granzyme B apoptotic pathways. Cleaves and activates caspase-3, -4, -6, -7, -8, and -9. Hydrolyzes the small- molecule substrates, Tyr-Val-Ala-Asp-|-AMC and Asp-Glu-Val-Asp-|-AMC. Ref.11 Isoform C is proteolytically inactive. Ref.11
Catalytic activity	Strict requirement for Asp at position P1 and has a preferred cleavage sequence of Leu-Gln-Thr-Asp-|-Gly.
Subunit structure	Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 23/17 kDa (p23/17) (depending on the splicing events) and a 12 kDa (p12) subunit By similarity. Self-associates. Interacts with FADD and CASP8. Found in a Fas signaling complex consisting of FAS, FADD, CASP8 and CASP10.
Tissue specificity	Detectable in most tissues. Lowest expression is seen in brain, kidney, prostate, testis and colon.
Post-translational modification	Cleavage by granzyme B and autocatalytic activity generate the two active subunits. Phosphorylated upon DNA damage, probably by ATM or ATR. Ref.13
Involvement in disease	Defects in CASP10 are the cause of autoimmune lymphoproliferative syndrome type 2A (ALPS2A) [MIM:603909]. ALPS2 is characterized by abnormal lymphocyte and dendritic cell homeostasis and immune regulatory defects. Ref.14 Ref.17 Defects in CASP10 are a cause of familial non-Hodgkin lymphoma (NHL) [MIM:605027]. NHL is a cancer that starts in cells of the lymph system, which is part of the body's immune system. NHLs can occur at any age and are often marked by enlarged lymph nodes, fever and weight loss. Ref.15 Defects in CASP10 are a cause of gastric cancers [MIM:137215].
Sequence similarities	Belongs to the peptidase C14A family. Contains 2 DED (death effector) domains.

Ontologies

Keywords
Biological process	Apoptosis
Coding sequence diversity	Alternative splicing Polymorphism
Disease	Disease mutation
Domain	Repeat
Molecular function	Hydrolase Protease Thiol protease
PTM	Phosphoprotein Zymogen
Technical term	Direct protein sequencing
Gene Ontology (GO)
Biological process	apoptosis Inferred from electronic annotation. Source: UniProtKB-KW induction of apoptosis by extracellular signals Inferred from Experiment. Source: Reactome proteolysis Inferred from electronic annotation. Source: InterPro
Molecular function	cysteine-type endopeptidase activity Ref.1 Ref.14 Traceable author statement. Source: ProtInc identical protein binding Ref.11 Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
itself		1	EBI-495095,EBI-495095
itself		1	EBI-495122,EBI-495122
CASP8	Q14790	2	EBI-495095,EBI-78060
EDA2R	Q9HAV5	1	EBI-495122,EBI-526033
FADD	Q13158	1	EBI-495095,EBI-494804

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform A (identifier: Q92851-1) Also known as: 10-A; This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform B (identifier: Q92851-2) Also known as: 10-B; 10-S; The sequence of this isoform differs from the canonical sequence as follows:      229-271: Missing.      473-521: MLKFLEKTME...PPMRRWSSVS → HEDILSILTA...FPVPLDALSL
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	479	1	L → I: dbSNP rs13006529.
Isoform D (identifier: Q92851-4) Also known as: 10-D; 10-L; The sequence of this isoform differs from the canonical sequence as follows:      473-521: MLKFLEKTME...PPMRRWSSVS → HEDILSILTA...FPVPLDALSL
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	522	1	L → I Not associated with significantly altered cutaneous melanoma risk. dbSNP rs13006529.
Isoform C (identifier: Q92851-3) Also known as: 10-C; The sequence of this isoform differs from the canonical sequence as follows:      241-273: GNRATNGAPSLVSRGMQGASANTLNSETSTKRA → EGSCVQDESEPQRPLCHCQQPQLYLPEGQTRNP      274-521: Missing.
Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Isoform 5 (identifier: Q92851-5) The sequence of this isoform differs from the canonical sequence as follows:      229-271: Missing.
Isoform 6 (identifier: Q92851-6) The sequence of this isoform differs from the canonical sequence as follows:      241-307: Missing.      473-521: MLKFLEKTME...PPMRRWSSVS → HEDILSILTA...FPVPLDALSL
Sequence annotation (Features)
	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
	Natural variant	455	1	L → I: dbSNP rs13006529.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Propeptide	1 – 219	219			PRO_0000004644
	Chain	220 – 415	196	Caspase-10 subunit p23/17		PRO_0000004645
	Chain	416 – 521	106	Caspase-10 subunit p12		PRO_0000004646
Regions
	Domain	19 – 97	79	DED 1
	Domain	114 – 187	74	DED 2
Sites
	Active site	358	1	By similarity
	Active site	401	1	By similarity
Amino acid modifications
	Modified residue	216	1	Phosphoserine Ref.13
Natural variations
	Alternative sequence	229 – 271	43	Missing in isoform B and isoform 5.		VSP_000819
	Alternative sequence	241 – 307	67	Missing in isoform 6.		VSP_037229
	Alternative sequence	241 – 273	33	GNRAT…STKRA → EGSCVQDESEPQRPLCHCQQ PQLYLPEGQTRNP in isoform C.		VSP_000821
	Alternative sequence	274 – 521	248	Missing in isoform C.		VSP_000822
	Alternative sequence	473 – 521	49	MLKFL…WSSVS → HEDILSILTAVNDDVSRRVD KQGTKKQMPQPAFTLRKKLV FPVPLDALSL in isoform B, isoform D and isoform 6.		VSP_000820
	Natural variant	147	1	M → T in gastric cancer; somatic mutation; impairs CASP10-mediated apoptosis. Ref.16		VAR_037428
	Natural variant	239	1	S → C		VAR_055361
	Natural variant	285	1	L → F in ALPS2A. dbSNP rs17860403. Ref.14		VAR_014071
	Natural variant	406	1	I → L in ALPS2A; the mutant protein has defective apoptosis and exerts a dominant-negative effect when cotransfected with the wild-type protein. Ref.17		VAR_037429
	Natural variant	410	1	V → I Does not interfere with apoptosis in a dominant negative manner. dbSNP rs13010627. Ref.14 Ref.17 Ref.3 Ref.18		VAR_014072
	Natural variant	414	1	A → V in NHL; somatic mutation. dbSNP rs28936699. Ref.15		VAR_037430
	Natural variant	444	1	P → S		VAR_055362
	Natural variant	446	1	Y → C Associated with ALPS2A; does not interfere with apoptosis in a dominant negative manner. dbSNP rs17860405. Ref.17		VAR_037431
Experimental info
	Mutagenesis	401	1	C → A: Abolishes proteolytic activity. Ref.11
	Sequence conflict	68	1	E → G in AAB46730. Ref.2
	Sequence conflict	268	1	T → A in AAD28403. Ref.3

Sequences

	Sequence		Length	Mass (Da)
	Isoform A (10-A) [UniParc]. Last modified January 11, 2001. Version 3. Checksum: 840348AE602B8243	FASTA	521	58,951
	10 20 30 40 50 60 MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 70 80 90 100 110 120 VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 130 140 150 160 170 180 ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 190 200 210 220 230 240 LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 250 260 270 280 290 300 GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 310 320 330 340 350 360 QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 370 380 390 400 410 420 FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 430 440 450 460 470 480 QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRMLKFLEKT 490 500 510 520 MEIRGRKRTV WGAKQISATS LPTAISAQTP RPPMRRWSSV S
	Isoform B (10-B) (10-S). Checksum: 1467FD7A4EE003FF	FASTA	479	54,566
	10 20 30 40 50 60 MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 70 80 90 100 110 120 VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 130 140 150 160 170 180 ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 190 200 210 220 230 240 LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPRA AVYRMNRNHR 250 260 270 280 290 300 GLCVIVNNHS FTSLKDRQGT HKDAEILSHV FQWLGFTVHI HNNVTKVEME MVLQKQKCNP 310 320 330 340 350 360 AHADGDCFVF CILTHGRFGA VYSSDEALIP IREIMSHFTA LQCPRLAEKP KLFFIQACQG 370 380 390 400 410 420 EEIQPSVSIE ADALNPEQAP TSLQDSIPAE ADFLLGLATV PGYVSFRHVE EGSWYIQSLC 430 440 450 460 470 NHLKKLVPRH EDILSILTAV NDDVSRRVDK QGTKKQMPQP AFTLRKKLVF PVPLDALSL
	Isoform D (10-D) (10-L). Checksum: 34847E07B3DFA688	FASTA	522	58,994
	10 20 30 40 50 60 MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 70 80 90 100 110 120 VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 130 140 150 160 170 180 ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 190 200 210 220 230 240 LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 250 260 270 280 290 300 GNRATNGAPS LVSRGMQGAS ANTLNSETST KRAAVYRMNR NHRGLCVIVN NHSFTSLKDR 310 320 330 340 350 360 QGTHKDAEIL SHVFQWLGFT VHIHNNVTKV EMEMVLQKQK CNPAHADGDC FVFCILTHGR 370 380 390 400 410 420 FGAVYSSDEA LIPIREIMSH FTALQCPRLA EKPKLFFIQA CQGEEIQPSV SIEADALNPE 430 440 450 460 470 480 QAPTSLQDSI PAEADFLLGL ATVPGYVSFR HVEEGSWYIQ SLCNHLKKLV PRHEDILSIL 490 500 510 520 TAVNDDVSRR VDKQGTKKQM PQPAFTLRKK LVFPVPLDAL SL
	Isoform C (10-C). Checksum: 1146630514EE38DC	FASTA	273	31,419
	10 20 30 40 50 60 MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 70 80 90 100 110 120 VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 130 140 150 160 170 180 ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 190 200 210 220 230 240 LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 250 260 270 EGSCVQDESE PQRPLCHCQQ PQLYLPEGQT RNP
	Isoform 5. Checksum: E78035535F8EF57B	FASTA	478	54,523
	10 20 30 40 50 60 MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 70 80 90 100 110 120 VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 130 140 150 160 170 180 ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 190 200 210 220 230 240 LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPRA AVYRMNRNHR 250 260 270 280 290 300 GLCVIVNNHS FTSLKDRQGT HKDAEILSHV FQWLGFTVHI HNNVTKVEME MVLQKQKCNP 310 320 330 340 350 360 AHADGDCFVF CILTHGRFGA VYSSDEALIP IREIMSHFTA LQCPRLAEKP KLFFIQACQG 370 380 390 400 410 420 EEIQPSVSIE ADALNPEQAP TSLQDSIPAE ADFLLGLATV PGYVSFRHVE EGSWYIQSLC 430 440 450 460 470 NHLKKLVPRM LKFLEKTMEI RGRKRTVWGA KQISATSLPT AISAQTPRPP MRRWSSVS
	Isoform 6. Checksum: 89037FC3EC173616	FASTA	455	51,785
	10 20 30 40 50 60 MKSQGQHWYS SSDKNCKVSF REKLLIIDSN LGVQDVENLK FLCIGLVPNK KLEKSSSASD 70 80 90 100 110 120 VFEHLLAEDL LSEEDPFFLA ELLYIIRQKK LLQHLNCTKE EVERLLPTRQ RVSLFRNLLY 130 140 150 160 170 180 ELSEGIDSEN LKDMIFLLKD SLPKTEMTSL SFLAFLEKQG KIDEDNLTCL EDLCKTVVPK 190 200 210 220 230 240 LLRNIEKYKR EKAIQIVTPP VDKEAESYQG EEELVSQTDV KTFLEALPQE SWQNKHAGSN 250 260 270 280 290 300 EILSHVFQWL GFTVHIHNNV TKVEMEMVLQ KQKCNPAHAD GDCFVFCILT HGRFGAVYSS 310 320 330 340 350 360 DEALIPIREI MSHFTALQCP RLAEKPKLFF IQACQGEEIQ PSVSIEADAL NPEQAPTSLQ 370 380 390 400 410 420 DSIPAEADFL LGLATVPGYV SFRHVEEGSW YIQSLCNHLK KLVPRHEDIL SILTAVNDDV 430 440 450 SRRVDKQGTK KQMPQPAFTL RKKLVFPVPL DALSL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"In vitro activation of CPP32 and Mch3 by Mch4, a novel human apoptotic cysteine protease containing two FADD-like domains." Fernandes-Alnemri T., Armstrong R.C., Krebs J.F., Srinivasula S.M., Wang L., Bullrich F., Fritz L.C., Trapani J.A., Tomaselli K.J., Litwack G., Alnemri E.S. Proc. Natl. Acad. Sci. U.S.A. 93:7464-7469(1996) [PubMed: 8755496] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM B), VARIANT ILE-479 (ISOFORM B). Tissue: T-cell.
[2]	"Fas-associated death domain protein interleukin-1beta-converting enzyme 2 (FLICE2), an ICE/Ced-3 homologue, is proximally involved in CD95- and p55-mediated death signaling." Vincenz C., Dixit V.M. J. Biol. Chem. 272:6578-6583(1997) [PubMed: 9045686] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM A).
[3]	"Molecular cloning and characterization of two novel pro-apoptotic isoforms of caspase-10." Ng P.W., Porter A.G., Janicke R.U. J. Biol. Chem. 274:10301-10308(1999) [PubMed: 10187817] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS C AND D), VARIANT ILE-410, VARIANT ILE-522 (ISOFORM D). Tissue: Spleen and Thymus.
[4]	"Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2." Hadano S., Yanagisawa Y., Skaug J., Fichter K., Nasir J., Martindale D., Koop B.F., Scherer S.W., Nicholson D.W., Rouleau G.A., Ikeda J.-E., Hayden M.R. Genomics 71:200-213(2001) [PubMed: 11161814] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], ALTERNATIVE SPLICING (ISOFORMS A AND B), VARIANT ILE-479 (ISOFORM B).
[5]	"A novel human caspase 10 isoform participating in Fas-induced apoptosis." Vonarbourg C., Fischer A., Rieux-Laucat F. Submitted (MAY-2004) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 5 AND 6), VARIANT ILE-455 (ISOFORM 6). Tissue: Blood.
[6]	NIEHS SNPs program Submitted (OCT-2006) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANTS CYS-239; ILE-410; SER-444; CYS-446 AND ILE-522 (ISOFORM 2).
[7]	"Generation and annotation of the DNA sequences of human chromosomes 2 and 4." Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. , Sun H., Bradshaw-Cordum H., Ali J., Carter J., Cordes M., Harris A., Isak A., van Brunt A., Nguyen C., Du F., Courtney L., Kalicki J., Ozersky P., Abbott S., Armstrong J., Belter E.A., Caruso L., Cedroni M., Cotton M., Davidson T., Desai A., Elliott G., Erb T., Fronick C., Gaige T., Haakenson W., Haglund K., Holmes A., Harkins R., Kim K., Kruchowski S.S., Strong C.M., Grewal N., Goyea E., Hou S., Levy A., Martinka S., Mead K., McLellan M.D., Meyer R., Randall-Maher J., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Shah N., Swearengen-Shahid S., Snider J., Strong J.T., Thompson J., Yoakum M., Leonard S., Pearman C., Trani L., Radionenko M., Waligorski J.E., Wang C., Rock S.M., Tin-Wollam A.-M., Maupin R., Latreille P., Wendl M.C., Yang S.-P., Pohl C., Wallis J.W., Spieth J., Bieri T.A., Berkowicz N., Nelson J.O., Osborne J., Ding L., Meyer R., Sabo A., Shotland Y., Sinha P., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Jones T.A., She X., Ciccarelli F.D., Izaurralde E., Taylor J., Schmutz J., Myers R.M., Cox D.R., Huang X., McPherson J.D., Mardis E.R., Clifton S.W., Warren W.C., Chinwalla A.T., Eddy S.R., Marra M.A., Ovcharenko I., Furey T.S., Miller W., Eichler E.E., Bork P., Suyama M., Torrents D., Waterston R.H., Wilson R.K. Nature 434:724-731(2005) [PubMed: 15815621] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[9]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM D). Tissue: Brain.
[10]	"Molecular ordering of the Fas-apoptotic pathway: the Fas/APO-1 protease Mch5 is a CrmA-inhibitable protease that activates multiple Ced-3/ICE-like cysteine proteases." Srinivasula S.M., Ahmad M., Fernandes-Alnemri T., Litwack G., Alnemri E.S. Proc. Natl. Acad. Sci. U.S.A. 93:14486-14491(1996) [PubMed: 8962078] [Abstract] Cited for: PARTIAL PROTEIN SEQUENCE, PROTEOLYTIC PROCESSING.
[11]	"Caspase-10 is an initiator caspase in death receptor signaling." Wang J., Chun H.J., Wong W., Spencer D.M., Lenardo M.J. Proc. Natl. Acad. Sci. U.S.A. 98:13884-13888(2001) [PubMed: 11717445] [Abstract] Cited for: FUNCTION, SELF-ASSOCIATION, INTERACTION WITH FADD, INTERACTION WITH CASP8, IDENTIFICATION IN A COMPLEX WITH FAS; FADD AND CASP8, MUTAGENESIS OF CYS-401.
[12]	"An unappreciated role for RNA surveillance." Hillman R.T., Green R.E., Brenner S.E. Genome Biol. 5:RESEARCH008.1-RESEARCH008.16(2004) [PubMed: 14759258] [Abstract] Cited for: SPLICE ISOFORM(S) THAT ARE POTENTIAL NMD TARGET(S).
[13]	"ATM and ATR substrate analysis reveals extensive protein networks responsive to DNA damage." Matsuoka S., Ballif B.A., Smogorzewska A., McDonald E.R. III, Hurov K.E., Luo J., Bakalarski C.E., Zhao Z., Solimini N., Lerenthal Y., Shiloh Y., Gygi S.P., Elledge S.J. Science 316:1160-1166(2007) [PubMed: 17525332] [Abstract] Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216, MASS SPECTROMETRY.
[14]	"Inherited human caspase 10 mutations underlie defective lymphocyte and dendritic cell apoptosis in autoimmune lymphoproliferative syndrome type II." Wang J., Zheng L., Lobito A., Chan F.K., Dale J., Sneller M., Yao X., Puck J.M., Straus S.E., Lenardo M.J. Cell 98:47-58(1999) [PubMed: 10412980] [Abstract] Cited for: ALTERNATIVE SPLICING (ISOFORMS B AND D), VARIANT ALPS2A PHE-285, VARIANT ILE-410.
[15]	"Inactivating mutations of CASP10 gene in non-Hodgkin lymphomas." Shin M.S., Kim H.S., Kang C.S., Park W.S., Kim S.Y., Lee S.N., Lee J.H., Park J.Y., Jang J.J., Kim C.W., Kim S.H., Lee J.Y., Yoo N.J., Lee S.H. Blood 99:4094-4099(2002) [PubMed: 12010812] [Abstract] Cited for: VARIANT NHL VAL-414.
[16]	"Inactivating mutations of the caspase-10 gene in gastric cancer." Park W.S., Lee J.H., Shin M.S., Park J.Y., Kim H.S., Lee J.H., Kim Y.S., Lee S.N., Xiao W., Park C.H., Lee S.H., Yoo N.J., Lee J.Y. Oncogene 21:2919-2925(2002) [PubMed: 11973654] [Abstract] Cited for: VARIANT GASTRIC CANCER THR-147, CHARACTERIZATION OF VARIANT GASTRIC CANCER THR-147.
[17]	"Genetic alterations in caspase-10 may be causative or protective in autoimmune lymphoproliferative syndrome." Zhu S., Hsu A.P., Vacek M.M., Zheng L., Schaeffer A.A., Dale J.K., Davis J., Fischer R.E., Straus S.E., Boruchov D., Saulsbury F.T., Lenardo M.J., Puck J.M. Hum. Genet. 119:284-294(2006) [PubMed: 16446975] [Abstract] Cited for: VARIANT ALPS2A LEU-406, VARIANTS ILE-410 AND CYS-446, CHARACTERIZATION OF VARIANTS ALPS2A LEU-406, CHARACTERIZATION OF VARIANTS ILE-410 AND CYS-446.
[18]	"Genetic variants and haplotypes of the caspase-8 and caspase-10 genes contribute to susceptibility to cutaneous melanoma." Li C., Zhao H., Hu Z., Liu Z., Wang L.-E., Gershenwald J.E., Prieto V.G., Lee J.E., Duvic M., Grimm E.A., Wei Q. Hum. Mutat. 29:1443-1451(2008) [PubMed: 18563783] [Abstract] Cited for: VARIANT ILE-522 (ISOFORM D), RISK FACTOR FOR CUTANEOUS MELANOMA.
+	Additional computationally mapped references.

Web resources

CASP10base

CASP10 mutation db

Autoimmune Lymphoproliferative Syndrome Database (ALPSbase)

Caspase-10 mutations causing ALPS type II

GeneReviews

NIEHS-SNPs

Cross-references

Sequence databases
EMBLGenBankDDBJ	U60519 mRNA. Translation: AAC50644.1. U86214 mRNA. Translation: AAB46730.1. AF111344 mRNA. Translation: AAD28402.1. AF111345 mRNA. Translation: AAD28403.1. AB038979 Genomic DNA. Translation: BAB32553.1. AB038979 Genomic DNA. Translation: BAB32554.1. AJ487678 mRNA. Translation: CAD32371.1. AJ487679 mRNA. Translation: CAD32372.1. EF050529 Genomic DNA. Translation: ABJ53426.1. AC007283 Genomic DNA. Translation: AAY24291.1. CH471063 Genomic DNA. Translation: EAW70248.1. CH471063 Genomic DNA. Translation: EAW70249.1. BC042844 mRNA. Translation: AAH42844.1.
IPI	IPI00216197. IPI00290791. IPI00334756. IPI00868860.
RefSeq	NP_001221.2. NP_116756.2. NP_116759.2.
UniGene	Hs.5353 Hs.599762
3D structure databases
HSSP	HSSP built from PDB template 1QTN based on UniProtKB Q9C0K4.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92851. 12 interactions.
Protein family/group databases
MEROPS	C14.011.
PTM databases
PhosphoSite	Q92851.
Proteomic databases
PRIDE	Q92851.
Genome annotation databases
Ensembl	ENSG00000003400. Homo sapiens. [Contig view]
GeneID	843.
KEGG	hsa:843.
Organism-specific databases
GeneCards	GC02P201756.
HGNC	HGNC:1500. CASP10.
HPA	CAB003780. HPA017059.
MIM	137215. phenotype. 601762. gene. 603909. phenotype. 605027. phenotype.
Orphanet	3261. Autoimmune lymphoproliferative syndrome.
PharmGKB	PA26084.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q92851.
Enzyme and pathway databases
BRENDA	3.4.22.63. 247.
Pathway_Interaction_DB	caspase_pathway. Caspase cascade in apoptosis. faspathway. FAS signaling pathway (CD95). trail_pathway. TRAIL signaling pathway.
Reactome	REACT_578. Apoptosis.
Gene expression databases
ArrayExpress	Q92851.
Bgee	Q92851.
CleanEx	HS_CASP10.
GermOnline	ENSG00000003400. Homo sapiens.
Family and domain databases
InterPro	IPR011029. DEATH-like. IPR001875. DED. IPR011600. Pept_C14_cat. IPR001309. Pept_C14_ICE_p20. IPR016129. Pept_C14_ICE_p20_AS. IPR002138. Pept_C14_p10. IPR002398. Pept_C14_p45. IPR015917. Pept_C14_p45_core. [Graphical view]
Gene3D	G3DSA:1.10.533.10. DEATH_like. 2 hits.
PANTHER	PTHR10454. Pept_C14_p45. 1 hit.
Pfam	PF01335. DED. 2 hits. PF00656. Peptidase_C14. 1 hit. [Graphical view]
PRINTS	PR00376. IL1BCENZYME.
SMART	SM00115. CASc. 1 hit. SM00031. DED. 2 hits. [Graphical view]
PROSITE	PS01122. CASPASE_CYS. 1 hit. PS01121. CASPASE_HIS. 1 hit. PS50207. CASPASE_P10. 1 hit. PS50208. CASPASE_P20. 1 hit. PS50168. DED. 2 hits. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	3530.
SOURCE	Search...

Entry information

Entry name

CASPA_HUMAN

Accession

Primary (citable) accession number: Q92851
Secondary accession number(s): Q6KF62 , Q6KF63, Q8IUP5, Q8WYQ8, Q99845, Q9Y2U6, Q9Y2U7

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 11, 2001
Last modified:	June 16, 2009
This is version 106 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)