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Protein

Bcl-2-like protein 2

Gene

BCL2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.1 Publication

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129473-MONOMER.
SIGNORiQ92843.

Protein family/group databases

TCDBi1.A.21.1.5. the bcl-2 (bcl-2) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-like protein 2
Short name:
Bcl2-L-2
Alternative name(s):
Apoptosis regulator Bcl-W
Gene namesi
Name:BCL2L2
Synonyms:BCLW, KIAA0271
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:995. BCL2L2.
HGNC:42959. BCL2L2-PABPN1.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Ensembl
  • extracellular exosome Source: UniProtKB
  • mitochondrial outer membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Mitochondrion

Pathology & Biotechi

Organism-specific databases

DisGeNETi599.
OpenTargetsiENSG00000129473.
ENSG00000258643.
PharmGKBiPA25307.

Chemistry databases

ChEMBLiCHEMBL4677.
GuidetoPHARMACOLOGYi2846.

Polymorphism and mutation databases

BioMutaiBCL2L2.
DMDMi296434404.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001430662 – 193Bcl-2-like protein 2Add BLAST192

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Isoform 3 (identifier: Q92843-2)
Modified residuei177PhosphoserineCombined sources1
Modified residuei262PhosphoserineCombined sources1
Modified residuei286Omega-N-methylarginineCombined sources1
Modified residuei290Omega-N-methylarginineCombined sources1

Keywords - PTMi

Acetylation, Methylation, Phosphoprotein

Proteomic databases

MaxQBiQ92843.
PaxDbiQ92843.
PeptideAtlasiQ92843.
PRIDEiQ92843.

PTM databases

iPTMnetiQ92843.
PhosphoSitePlusiQ92843.

Expressioni

Tissue specificityi

Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.1 Publication

Gene expression databases

BgeeiENSG00000129473.
CleanExiHS_BCL2L2.
ExpressionAtlasiQ92843. baseline and differential.
GenevisibleiQ92843. HS.

Organism-specific databases

HPAiCAB040539.
HPA000637.

Interactioni

Subunit structurei

Interacts with HIF3A (via C-terminus domain). Interacts with BOP.By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
BAK1Q166117EBI-707714,EBI-519866
BAXQ078123EBI-707714,EBI-516580
BBC3Q9BXH12EBI-707714,EBI-519884
BCL2L11O435214EBI-707714,EBI-526406
BIDP559575EBI-707714,EBI-519672
BIKQ1332315EBI-707714,EBI-700794
BMFQ96LC97EBI-707714,EBI-3919268
BmfQ91ZE92EBI-707714,EBI-708032From a different organism.
BOPQ7L3V25EBI-707714,EBI-10697720
CCDC155Q8N6L07EBI-707714,EBI-749265
FATE1Q969F05EBI-707714,EBI-743099
TCF4P158843EBI-707714,EBI-533224
TEX11Q8IYF3-33EBI-707714,EBI-11523345
TP53BP2Q136252EBI-707714,EBI-77642

GO - Molecular functioni

Protein-protein interaction databases

BioGridi107071. 23 interactors.
DIPiDIP-33700N.
IntActiQ92843. 23 interactors.
MINTiMINT-206525.
STRINGi9606.ENSP00000250405.

Chemistry databases

BindingDBiQ92843.

Structurei

Secondary structure

1193
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi10 – 24Combined sources15
Beta strandi30 – 32Combined sources3
Beta strandi35 – 37Combined sources3
Helixi41 – 60Combined sources20
Helixi65 – 67Combined sources3
Turni68 – 70Combined sources3
Turni72 – 74Combined sources3
Helixi75 – 86Combined sources12
Turni87 – 89Combined sources3
Helixi93 – 112Combined sources20
Helixi117 – 133Combined sources17
Helixi135 – 140Combined sources6
Helixi144 – 151Combined sources8
Helixi156 – 168Combined sources13
Turni171 – 176Combined sources6

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MK3NMR-A2-171[»]
1O0LNMR-A1-183[»]
1ZY3NMR-A2-171[»]
2Y6WX-ray2.00A/B1-164[»]
4CIMX-ray1.50A/B1-163[»]
P/Q38-58[»]
ProteinModelPortaliQ92843.
SMRiQ92843.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92843.

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi9 – 29BH4Add BLAST21
Motifi85 – 104BH1Add BLAST20
Motifi136 – 151BH2Add BLAST16

Domaini

The BH4 motif seems to be involved in the anti-apoptotic function.
The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
GeneTreeiENSGT00390000001517.
ENSGT00530000062935.
HOGENOMiHOG000056452.
InParanoidiQ92843.
KOiK02163.
OMAiVQDWMVT.
OrthoDBiEOG091G0PAK.
PhylomeDBiQ92843.
TreeFamiTF105907.
TF315834.

Family and domain databases

InterProiIPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF13. PTHR11256:SF13. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92843-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG
60 70 80 90 100
DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF
110 120 130 140 150
VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL
160 170 180 190
YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK
Length:193
Mass (Da):20,746
Last modified:May 18, 2010 - v2
Checksum:i3542243A532B1762
GO
Isoform 3 (identifier: Q92843-2) [UniParc]FASTAAdd to basket
Also known as: BCL2L2-PABPN1

The sequence of this isoform differs from the canonical sequence as follows:
     145-193: AEFTALYGDG...VTVGAFFASK → ELEAIKARVR...ARATSWYSPY

Note: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein. No experimental confirmation available.Combined sources
Show »
Length:333
Mass (Da):37,171
Checksum:iF2C9A67BF3D38122
GO

Sequence cautioni

The sequence BAA19666 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_048418133Q → R.6 PublicationsCorresponds to variant rs910332dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_042064145 – 193AEFTA…FFASK → ELEAIKARVREMEEEAEKLK ELQNEVEKQMNMSPPPGNAG PVIMSIEEKMEADARSIYVG NVDYGATAEELEAHFHGCGS VNRVTILCDKFSGHPKGFAY IEFSDKESVRTSLALDESLF RGRQIKVIPKRTNRPGISTT DRGFPRARYRARTTNYNSSR SRFYSGFNSRPRGRVYRGRA RATSWYSPY in isoform 3. 1 PublicationAdd BLAST49

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59747 mRNA. Translation: AAB09055.1.
D87461 mRNA. Translation: BAA19666.2. Different initiation.
BT019549 mRNA. Translation: AAV38356.1.
AK289519 mRNA. Translation: BAF82208.1.
AL049829 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66169.1.
BC011637 mRNA. No translation available.
BC021198 mRNA. Translation: AAH21198.1.
BC104789 mRNA. Translation: AAI04790.1.
BC113522 mRNA. Translation: AAI13523.1.
RefSeqiNP_001186768.1. NM_001199839.1.
NP_004041.1. NM_004050.4.
UniGeneiHs.410026.
Hs.735863.

Genome annotation databases

EnsembliENST00000250405; ENSP00000250405; ENSG00000129473. [Q92843-1]
ENST00000553781; ENSP00000451320; ENSG00000258643. [Q92843-2]
ENST00000557008; ENSP00000452479; ENSG00000258643. [Q92843-2]
GeneIDi599.
KEGGihsa:599.
UCSCiuc001wjg.4. human. [Q92843-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59747 mRNA. Translation: AAB09055.1.
D87461 mRNA. Translation: BAA19666.2. Different initiation.
BT019549 mRNA. Translation: AAV38356.1.
AK289519 mRNA. Translation: BAF82208.1.
AL049829 Genomic DNA. No translation available.
CH471078 Genomic DNA. Translation: EAW66169.1.
BC011637 mRNA. No translation available.
BC021198 mRNA. Translation: AAH21198.1.
BC104789 mRNA. Translation: AAI04790.1.
BC113522 mRNA. Translation: AAI13523.1.
RefSeqiNP_001186768.1. NM_001199839.1.
NP_004041.1. NM_004050.4.
UniGeneiHs.410026.
Hs.735863.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1MK3NMR-A2-171[»]
1O0LNMR-A1-183[»]
1ZY3NMR-A2-171[»]
2Y6WX-ray2.00A/B1-164[»]
4CIMX-ray1.50A/B1-163[»]
P/Q38-58[»]
ProteinModelPortaliQ92843.
SMRiQ92843.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi107071. 23 interactors.
DIPiDIP-33700N.
IntActiQ92843. 23 interactors.
MINTiMINT-206525.
STRINGi9606.ENSP00000250405.

Chemistry databases

BindingDBiQ92843.
ChEMBLiCHEMBL4677.
GuidetoPHARMACOLOGYi2846.

Protein family/group databases

TCDBi1.A.21.1.5. the bcl-2 (bcl-2) family.

PTM databases

iPTMnetiQ92843.
PhosphoSitePlusiQ92843.

Polymorphism and mutation databases

BioMutaiBCL2L2.
DMDMi296434404.

Proteomic databases

MaxQBiQ92843.
PaxDbiQ92843.
PeptideAtlasiQ92843.
PRIDEiQ92843.

Protocols and materials databases

DNASUi599.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000250405; ENSP00000250405; ENSG00000129473. [Q92843-1]
ENST00000553781; ENSP00000451320; ENSG00000258643. [Q92843-2]
ENST00000557008; ENSP00000452479; ENSG00000258643. [Q92843-2]
GeneIDi599.
KEGGihsa:599.
UCSCiuc001wjg.4. human. [Q92843-1]

Organism-specific databases

CTDi599.
DisGeNETi599.
GeneCardsiBCL2L2.
BCL2L2-PABPN1.
HGNCiHGNC:995. BCL2L2.
HGNC:42959. BCL2L2-PABPN1.
HPAiCAB040539.
HPA000637.
MIMi601931. gene.
neXtProtiNX_Q92843.
OpenTargetsiENSG00000129473.
ENSG00000258643.
PharmGKBiPA25307.
HUGEiSearch...
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4209. Eukaryota.
ENOG4111PFV. LUCA.
GeneTreeiENSGT00390000001517.
ENSGT00530000062935.
HOGENOMiHOG000056452.
InParanoidiQ92843.
KOiK02163.
OMAiVQDWMVT.
OrthoDBiEOG091G0PAK.
PhylomeDBiQ92843.
TreeFamiTF105907.
TF315834.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000129473-MONOMER.
SIGNORiQ92843.

Miscellaneous databases

ChiTaRSiBCL2L2. human.
EvolutionaryTraceiQ92843.
GeneWikiiBCL2L2.
GenomeRNAii599.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000129473.
CleanExiHS_BCL2L2.
ExpressionAtlasiQ92843. baseline and differential.
GenevisibleiQ92843. HS.

Family and domain databases

InterProiIPR013280. Apop_reg_BclW.
IPR002475. Bcl2-like.
IPR020717. Bcl2_BH1_motif_CS.
IPR020726. Bcl2_BH2_motif_CS.
IPR003093. Bcl2_BH4.
IPR020731. Bcl2_BH4_motif_CS.
IPR026298. Blc2_fam.
[Graphical view]
PANTHERiPTHR11256. PTHR11256. 1 hit.
PTHR11256:SF13. PTHR11256:SF13. 1 hit.
PfamiPF00452. Bcl-2. 1 hit.
PF02180. BH4. 1 hit.
[Graphical view]
PRINTSiPR01865. APOPREGBCLW.
PR01862. BCL2FAMILY.
SMARTiSM00265. BH4. 1 hit.
[Graphical view]
PROSITEiPS50062. BCL2_FAMILY. 1 hit.
PS01080. BH1. 1 hit.
PS01258. BH2. 1 hit.
PS01260. BH4_1. 1 hit.
PS50063. BH4_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiB2CL2_HUMAN
AccessioniPrimary (citable) accession number: Q92843
Secondary accession number(s): A8K0F4, Q2M3U0, Q5U0H4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 168 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.