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Q92843

- B2CL2_HUMAN

UniProt

Q92843 - B2CL2_HUMAN

Protein

Bcl-2-like protein 2

Gene

BCL2L2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 144 (01 Oct 2014)
      Sequence version 2 (18 May 2010)
      Previous versions | rss
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    Functioni

    Promotes cell survival. Blocks dexamethasone-induced apoptosis. Mediates survival of postmitotic Sertoli cells by suppressing death-promoting activity of BAX.1 Publication

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. protein heterodimerization activity Source: RefGenome
    3. protein homodimerization activity Source: RefGenome

    GO - Biological processi

    1. extrinsic apoptotic signaling pathway in absence of ligand Source: RefGenome
    2. intrinsic apoptotic signaling pathway in response to DNA damage Source: RefGenome
    3. negative regulation of apoptotic process Source: UniProtKB
    4. negative regulation of intrinsic apoptotic signaling pathway Source: RefGenome
    5. Sertoli cell proliferation Source: Ensembl
    6. spermatogenesis Source: ProtInc

    Keywords - Biological processi

    Apoptosis

    Protein family/group databases

    TCDBi1.A.21.1.5. the bcl-2 (bcl-2) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Bcl-2-like protein 2
    Short name:
    Bcl2-L-2
    Alternative name(s):
    Apoptosis regulator Bcl-W
    Gene namesi
    Name:BCL2L2
    Synonyms:BCLW, KIAA0271
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 14

    Organism-specific databases

    HGNCiHGNC:995. BCL2L2.
    HGNC:42959. BCL2L2-PABPN1.

    Subcellular locationi

    Mitochondrion membrane 2 Publications; Peripheral membrane protein 2 Publications
    Note: Loosely associated with the mitochondrial membrane in healthy cells. During apoptosis, tightly bound to the membrane.

    GO - Cellular componenti

    1. cytosol Source: Ensembl
    2. extracellular vesicular exosome Source: UniProt
    3. mitochondrial outer membrane Source: RefGenome

    Keywords - Cellular componenti

    Membrane, Mitochondrion

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA25307.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11Removed1 Publication
    Chaini2 – 193192Bcl-2-like protein 2PRO_0000143066Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92843.
    PaxDbiQ92843.
    PRIDEiQ92843.

    PTM databases

    PhosphoSiteiQ92843.

    Expressioni

    Tissue specificityi

    Expressed (at protein level) in a wide range of tissues with highest levels in brain, spinal cord, testis, pancreas, heart, spleen and mammary glands. Moderate levels found in thymus, ovary and small intestine. Not detected in salivary gland, muscle or liver. Also expressed in cell lines of myeloid, fibroblast and epithelial origin. Not detected in most lymphoid cell lines.1 Publication

    Gene expression databases

    ArrayExpressiQ92843.
    BgeeiQ92843.
    CleanExiHS_BCL2L2.
    GenevestigatoriQ92843.

    Organism-specific databases

    HPAiCAB040539.
    HPA000637.

    Interactioni

    Subunit structurei

    Interacts with BOP.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    BAXQ078123EBI-707714,EBI-516580
    BBC3Q9BXH12EBI-707714,EBI-519884
    BCL2L11O435214EBI-707714,EBI-526406
    BIDP559575EBI-707714,EBI-519672
    BIKQ133232EBI-707714,EBI-700794
    BmfQ91ZE92EBI-707714,EBI-708032From a different organism.
    TP53BP2Q136252EBI-707714,EBI-77642

    Protein-protein interaction databases

    BioGridi107071. 13 interactions.
    DIPiDIP-33700N.
    IntActiQ92843. 13 interactions.
    MINTiMINT-206525.
    STRINGi9606.ENSP00000250405.

    Structurei

    Secondary structure

    1
    193
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi10 – 2415
    Beta strandi30 – 323
    Helixi33 – 353
    Helixi41 – 7030
    Helixi72 – 743
    Helixi75 – 8814
    Helixi92 – 11221
    Helixi117 – 13115
    Turni132 – 1343
    Helixi135 – 1406
    Helixi143 – 1519
    Helixi156 – 16813
    Turni171 – 1766

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1MK3NMR-A2-171[»]
    1O0LNMR-A1-183[»]
    1ZY3NMR-A2-171[»]
    2Y6WX-ray2.00A/B1-164[»]
    ProteinModelPortaliQ92843.
    SMRiQ92843. Positions 1-183.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92843.

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi9 – 2921BH4Add
    BLAST
    Motifi85 – 10420BH1Add
    BLAST
    Motifi136 – 15116BH2Add
    BLAST

    Domaini

    The BH4 motif seems to be involved in the anti-apoptotic function.
    The BH1 and BH2 motifs form a hydrophobic groove which acts as a docking site for the BH3 domain of some pro-apoptotic proteins. The C-terminal residues of BCL2L2 fold into the BH3-binding cleft and modulate pro-survival activity by regulating ligand access. When BH3 domain-containing proteins bind, they displace the C-terminus, allowing its insertion into the membrane and neutralizing the pro-survival activity of BCL2L2.

    Sequence similaritiesi

    Belongs to the Bcl-2 family.Curated

    Phylogenomic databases

    eggNOGiNOG300479.
    HOGENOMiHOG000056452.
    InParanoidiQ92843.
    KOiK02163.
    OMAiCAVSIRI.
    PhylomeDBiQ92843.
    TreeFamiTF105907.
    TF315834.

    Family and domain databases

    InterProiIPR013280. Apop_reg_BclW.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR003093. Bcl2_BH4.
    IPR020731. Bcl2_BH4_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view]
    PANTHERiPTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF13. PTHR11256:SF13. 1 hit.
    PfamiPF00452. Bcl-2. 1 hit.
    PF02180. BH4. 1 hit.
    [Graphical view]
    PRINTSiPR01865. APOPREGBCLW.
    PR01862. BCL2FAMILY.
    SMARTiSM00265. BH4. 1 hit.
    [Graphical view]
    PROSITEiPS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01260. BH4_1. 1 hit.
    PS50063. BH4_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92843-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MATPASAPDT RALVADFVGY KLRQKGYVCG AGPGEGPAAD PLHQAMRAAG    50
    DEFETRFRRT FSDLAAQLHV TPGSAQQRFT QVSDELFQGG PNWGRLVAFF 100
    VFGAALCAES VNKEMEPLVG QVQEWMVAYL ETQLADWIHS SGGWAEFTAL 150
    YGDGALEEAR RLREGNWASV RTVLTGAVAL GALVTVGAFF ASK 193
    Length:193
    Mass (Da):20,746
    Last modified:May 18, 2010 - v2
    Checksum:i3542243A532B1762
    GO
    Isoform 3 (identifier: Q92843-2) [UniParc]FASTAAdd to Basket

    Also known as: BCL2L2-PABPN1

    The sequence of this isoform differs from the canonical sequence as follows:
         145-193: AEFTALYGDG...VTVGAFFASK → ELEAIKARVR...ARATSWYSPY

    Note: Based on a readthrough transcript which may produce a BCL2L2-PABPN1 fusion protein. No experimental confirmation available. Contains a phosphoserine at position 177.

    Show »
    Length:333
    Mass (Da):37,171
    Checksum:iF2C9A67BF3D38122
    GO

    Sequence cautioni

    The sequence BAA19666.2 differs from that shown. Reason: Erroneous initiation. Translation N-terminally shortened.

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti133 – 1331Q → R.6 Publications
    Corresponds to variant rs910332 [ dbSNP | Ensembl ].
    VAR_048418

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei145 – 19349AEFTA…FFASK → ELEAIKARVREMEEEAEKLK ELQNEVEKQMNMSPPPGNAG PVIMSIEEKMEADARSIYVG NVDYGATAEELEAHFHGCGS VNRVTILCDKFSGHPKGFAY IEFSDKESVRTSLALDESLF RGRQIKVIPKRTNRPGISTT DRGFPRARYRARTTNYNSSR SRFYSGFNSRPRGRVYRGRA RATSWYSPY in isoform 3. 1 PublicationVSP_042064Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59747 mRNA. Translation: AAB09055.1.
    D87461 mRNA. Translation: BAA19666.2. Different initiation.
    BT019549 mRNA. Translation: AAV38356.1.
    AK289519 mRNA. Translation: BAF82208.1.
    AL049829 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66169.1.
    BC011637 mRNA. No translation available.
    BC021198 mRNA. Translation: AAH21198.1.
    BC104789 mRNA. Translation: AAI04790.1.
    BC113522 mRNA. Translation: AAI13523.1.
    RefSeqiNP_001186768.1. NM_001199839.1.
    NP_004041.1. NM_004050.4.
    UniGeneiHs.410026.
    Hs.735863.

    Genome annotation databases

    EnsembliENST00000250405; ENSP00000250405; ENSG00000129473. [Q92843-1]
    ENST00000553781; ENSP00000451320; ENSG00000258643. [Q92843-2]
    ENST00000557008; ENSP00000452479; ENSG00000258643. [Q92843-2]
    GeneIDi599.
    KEGGihsa:599.
    UCSCiuc001wjg.4. human. [Q92843-1]
    uc001wjh.4. human. [Q92843-2]

    Polymorphism databases

    DMDMi296434404.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U59747 mRNA. Translation: AAB09055.1 .
    D87461 mRNA. Translation: BAA19666.2 . Different initiation.
    BT019549 mRNA. Translation: AAV38356.1 .
    AK289519 mRNA. Translation: BAF82208.1 .
    AL049829 Genomic DNA. No translation available.
    CH471078 Genomic DNA. Translation: EAW66169.1 .
    BC011637 mRNA. No translation available.
    BC021198 mRNA. Translation: AAH21198.1 .
    BC104789 mRNA. Translation: AAI04790.1 .
    BC113522 mRNA. Translation: AAI13523.1 .
    RefSeqi NP_001186768.1. NM_001199839.1.
    NP_004041.1. NM_004050.4.
    UniGenei Hs.410026.
    Hs.735863.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1MK3 NMR - A 2-171 [» ]
    1O0L NMR - A 1-183 [» ]
    1ZY3 NMR - A 2-171 [» ]
    2Y6W X-ray 2.00 A/B 1-164 [» ]
    ProteinModelPortali Q92843.
    SMRi Q92843. Positions 1-183.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 107071. 13 interactions.
    DIPi DIP-33700N.
    IntActi Q92843. 13 interactions.
    MINTi MINT-206525.
    STRINGi 9606.ENSP00000250405.

    Chemistry

    ChEMBLi CHEMBL4677.

    Protein family/group databases

    TCDBi 1.A.21.1.5. the bcl-2 (bcl-2) family.

    PTM databases

    PhosphoSitei Q92843.

    Polymorphism databases

    DMDMi 296434404.

    Proteomic databases

    MaxQBi Q92843.
    PaxDbi Q92843.
    PRIDEi Q92843.

    Protocols and materials databases

    DNASUi 599.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000250405 ; ENSP00000250405 ; ENSG00000129473 . [Q92843-1 ]
    ENST00000553781 ; ENSP00000451320 ; ENSG00000258643 . [Q92843-2 ]
    ENST00000557008 ; ENSP00000452479 ; ENSG00000258643 . [Q92843-2 ]
    GeneIDi 599.
    KEGGi hsa:599.
    UCSCi uc001wjg.4. human. [Q92843-1 ]
    uc001wjh.4. human. [Q92843-2 ]

    Organism-specific databases

    CTDi 599.
    GeneCardsi GC14P023776.
    GC14P023777.
    HGNCi HGNC:995. BCL2L2.
    HGNC:42959. BCL2L2-PABPN1.
    HPAi CAB040539.
    HPA000637.
    MIMi 601931. gene.
    neXtProti NX_Q92843.
    PharmGKBi PA25307.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG300479.
    HOGENOMi HOG000056452.
    InParanoidi Q92843.
    KOi K02163.
    OMAi CAVSIRI.
    PhylomeDBi Q92843.
    TreeFami TF105907.
    TF315834.

    Miscellaneous databases

    ChiTaRSi BCL2L2. human.
    EvolutionaryTracei Q92843.
    GeneWikii BCL2L2.
    GenomeRNAii 599.
    NextBioi 2439.
    PROi Q92843.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92843.
    Bgeei Q92843.
    CleanExi HS_BCL2L2.
    Genevestigatori Q92843.

    Family and domain databases

    InterProi IPR013280. Apop_reg_BclW.
    IPR002475. Bcl2-like.
    IPR020717. Bcl2_BH1_motif_CS.
    IPR020726. Bcl2_BH2_motif_CS.
    IPR003093. Bcl2_BH4.
    IPR020731. Bcl2_BH4_motif_CS.
    IPR026298. Blc2_fam.
    [Graphical view ]
    PANTHERi PTHR11256. PTHR11256. 1 hit.
    PTHR11256:SF13. PTHR11256:SF13. 1 hit.
    Pfami PF00452. Bcl-2. 1 hit.
    PF02180. BH4. 1 hit.
    [Graphical view ]
    PRINTSi PR01865. APOPREGBCLW.
    PR01862. BCL2FAMILY.
    SMARTi SM00265. BH4. 1 hit.
    [Graphical view ]
    PROSITEi PS50062. BCL2_FAMILY. 1 hit.
    PS01080. BH1. 1 hit.
    PS01258. BH2. 1 hit.
    PS01260. BH4_1. 1 hit.
    PS50063. BH4_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Bcl-w, a novel member of the Bcl-2 family, promotes cell survival."
      Gibson L., Holmgreen S.P., Huang D.C., Bernard O., Copeland N.G., Jenkins N.A., Sutherland G.R., Baker E., Adams J.M., Cory S.
      Oncogene 13:665-675(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, VARIANT ARG-133.
    2. "Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain."
      Nagase T., Seki N., Ishikawa K., Ohira M., Kawarabayasi Y., Ohara O., Tanaka A., Kotani H., Miyajima N., Nomura N.
      DNA Res. 3:321-329(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-133.
      Tissue: Brain.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-133.
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT ARG-133.
      Tissue: Cerebellum.
    5. "The DNA sequence and analysis of human chromosome 14."
      Heilig R., Eckenberg R., Petit J.-L., Fonknechten N., Da Silva C., Cattolico L., Levy M., Barbe V., De Berardinis V., Ureta-Vidal A., Pelletier E., Vico V., Anthouard V., Rowen L., Madan A., Qin S., Sun H., Du H.
      , Pepin K., Artiguenave F., Robert C., Cruaud C., Bruels T., Jaillon O., Friedlander L., Samson G., Brottier P., Cure S., Segurens B., Aniere F., Samain S., Crespeau H., Abbasi N., Aiach N., Boscus D., Dickhoff R., Dors M., Dubois I., Friedman C., Gouyvenoux M., James R., Madan A., Mairey-Estrada B., Mangenot S., Martins N., Menard M., Oztas S., Ratcliffe A., Shaffer T., Trask B., Vacherie B., Bellemere C., Belser C., Besnard-Gonnet M., Bartol-Mavel D., Boutard M., Briez-Silla S., Combette S., Dufosse-Laurent V., Ferron C., Lechaplais C., Louesse C., Muselet D., Magdelenat G., Pateau E., Petit E., Sirvain-Trukniewicz P., Trybou A., Vega-Czarny N., Bataille E., Bluet E., Bordelais I., Dubois M., Dumont C., Guerin T., Haffray S., Hammadi R., Muanga J., Pellouin V., Robert D., Wunderle E., Gauguet G., Roy A., Sainte-Marthe L., Verdier J., Verdier-Discala C., Hillier L.W., Fulton L., McPherson J., Matsuda F., Wilson R., Scarpelli C., Gyapay G., Wincker P., Saurin W., Quetier F., Waterston R., Hood L., Weissenbach J.
      Nature 421:601-607(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ARG-133.
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 3), VARIANT ARG-133.
      Tissue: Brain, Lung and Rhabdomyosarcoma.
    8. "Tissue expression and subcellular localization of the pro-survival molecule Bcl-w."
      O'Reilly L.A., Print C., Hausmann G., Moriishi K., Cory S., Huang D.C.S., Strasser A.
      Cell Death Differ. 8:486-494(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
    9. "Proapoptotic BH3-only proteins trigger membrane integration of prosurvival Bcl-w and neutralize its activity."
      Wilson-Annan J., O'Reilly L.A., Crawford S.A., Hausmann G., Beaumont J.G., Parma L.P., Chen L., Lackmann M., Lithgow T., Hinds M.G., Day C.L., Adams J.M., Huang D.C.S.
      J. Cell Biol. 162:877-887(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: SUBCELLULAR LOCATION.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT ALA-2, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS], CLEAVAGE OF INITIATOR METHIONINE [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-177 (ISOFORM 3), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. "The structure of Bcl-w reveals a role for the C-terminal residues in modulating biological activity."
      Hinds M.G., Lackmann M., Skea G.L., Harrison P.J., Huang D.C.S., Day C.L.
      EMBO J. 22:1497-1507(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 1-183.
    17. "Solution structure of human BCL-w: modulation of ligand binding by the C-terminal helix."
      Denisov A.Y., Madiraju M.S.R., Chen G., Khadir A., Beauparlant P., Attardo G., Shore G.C., Gehring K.
      J. Biol. Chem. 278:21124-21128(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 2-171.

    Entry informationi

    Entry nameiB2CL2_HUMAN
    AccessioniPrimary (citable) accession number: Q92843
    Secondary accession number(s): A8K0F4, Q2M3U0, Q5U0H4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 144 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 14
      Human chromosome 14: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3