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Protein

Probable ATP-dependent RNA helicase DDX17

Gene

DDX17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA-dependent ATPase activity. Involved in transcriptional regulation. Transcriptional coactivator for estrogen receptor ESR1. Increases ESR1 AF-1 domain-mediated transactivation. Synergizes with DDX5 and SRA1 RNA to activate MYOD1 transcriptional activity and probably involved in skeletal muscle differentiation. Required for zinc-finger antiviral protein ZC3HAV1-mediated mRNA degradation.6 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi215 – 222ATPPROSITE-ProRule annotation8

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • ATP-dependent RNA helicase activity Source: GO_Central
  • estrogen receptor binding Source: UniProtKB
  • poly(A) RNA binding Source: UniProtKB
  • RNA binding Source: ProtInc
  • RNA-dependent ATPase activity Source: ProtInc
  • RNA helicase activity Source: ProtInc
  • transcription coactivator activity Source: UniProtKB

GO - Biological processi

  • positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • regulation of skeletal muscle cell differentiation Source: UniProtKB
  • RNA processing Source: ProtInc
  • RNA secondary structure unwinding Source: GO_Central
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100201-MONOMER.
SIGNORiQ92841.

Names & Taxonomyi

Protein namesi
Recommended name:
Probable ATP-dependent RNA helicase DDX17 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 17
DEAD box protein p72
RNA-dependent helicase p72
Gene namesi
Name:DDX17
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:2740. DDX17.

Subcellular locationi

GO - Cellular componenti

  • membrane Source: UniProtKB
  • nucleolus Source: UniProtKB-SubCell
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi129K → R: Impaired sumoylation and decreased stability. 1 Publication1

Organism-specific databases

DisGeNETi10521.
PharmGKBiPA27206.

Polymorphism and mutation databases

BioMutaiDDX17.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000549931 – 729Probable ATP-dependent RNA helicase DDX17Add BLAST729

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei64PhosphoserineCombined sources1
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources
Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei523PhosphothreonineCombined sources1
Modified residuei684Omega-N-methylarginineCombined sources1

Post-translational modificationi

Sumoylation significantly increases stability, it also promotes interaction with HDAC1.1 Publication

Keywords - PTMi

Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92841.
MaxQBiQ92841.
PaxDbiQ92841.
PeptideAtlasiQ92841.
PRIDEiQ92841.
TopDownProteomicsiQ92841-1. [Q92841-1]
Q92841-4. [Q92841-4]

2D gel databases

REPRODUCTION-2DPAGEIPI00023785.

PTM databases

iPTMnetiQ92841.
PhosphoSitePlusiQ92841.
SwissPalmiQ92841.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000100201.
CleanExiHS_DDX17.
ExpressionAtlasiQ92841. baseline and differential.
GenevisibleiQ92841. HS.

Organism-specific databases

HPAiCAB024908.
HPA063142.

Interactioni

Subunit structurei

Interacts with ESR1. Interacts with NCOA1, NCOA2, NCOA3, TP53 and HDAC1. Self-associates. Interacts with DDX5. Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner. Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3 and EXOSC5 only in the presence of ZC3HAV1 in an RNA-independent manner.9 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
BYSLQ138955EBI-746012,EBI-358049
DDX5P178443EBI-746012,EBI-351962
ESR1P033728EBI-746012,EBI-78473
GRB2P629933EBI-746012,EBI-401755
HDAC1Q135473EBI-5280703,EBI-301834
LNX1Q8TBB13EBI-746012,EBI-739832
NCOA2Q155962EBI-746012,EBI-81236
NCOA3Q9Y6Q92EBI-746012,EBI-81196
NFAT5O949163EBI-746012,EBI-308320
RBM15Q96T375EBI-746012,EBI-2514922
SF1Q156374EBI-746012,EBI-744603
Srek1Q9JKL73EBI-746012,EBI-6452221From a different organism.
TP53P046373EBI-746012,EBI-366083
YAP1P469377EBI-746012,EBI-1044059

GO - Molecular functioni

  • estrogen receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115776. 154 interactors.
DIPiDIP-29843N.
IntActiQ92841. 78 interactors.
MINTiMINT-4545892.
STRINGi9606.ENSP00000380033.

Structurei

3D structure databases

ProteinModelPortaliQ92841.
SMRiQ92841.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini202 – 377Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
Domaini405 – 552Helicase C-terminalPROSITE-ProRule annotationAdd BLAST148

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni547 – 729Transactivation domainAdd BLAST183

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi171 – 199Q motifAdd BLAST29
Motifi325 – 328DEAD box4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi101 – 104Poly-Gly4
Compositional biasi556 – 563Poly-Gly8
Compositional biasi718 – 726Poly-Pro9

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
HOGENOMiHOG000268804.
HOVERGENiHBG015893.
InParanoidiQ92841.
KOiK13178.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

Isoform 1 (identifier: Q92841-4) [UniParc]FASTAAdd to basket
Also known as: p82

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP
60 70 80 90 100
PSVVTRPEPQ ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR
110 120 130 140 150
GGGGLPPKKF GNPGERLRKK KWDLSELPKF EKNFYVEHPE VARLTPYEVD
160 170 180 190 200
ELRRKKEITV RGGDVCPKPV FAFHHANFPQ YVMDVLMDQH FTEPTPIQCQ
210 220 230 240 250
GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE RGDGPICLVL
260 270 280 290 300
APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
310 320 330 340 350
TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR
360 370 380 390 400
QTLMWSATWP KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES
410 420 430 440 450
EKDHKLIQLM EEIMAEKENK TIIFVETKRR CDDLTRRMRR DGWPAMCIHG
460 470 480 490 500
DKSQPERDWV LNEFRSGKAP ILIATDVASR GLDVEDVKFV INYDYPNSSE
510 520 530 540 550
DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA NQAINPKLMQ
560 570 580 590 600
LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
610 620 630 640 650
SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY
660 670 680 690 700
TAQEYGAGTY GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP
710 720
PGATNMIGYM GQTAYQYPPP PPPPPPSRK
Note: Starts at an alternative CUG codon.
Length:729
Mass (Da):80,272
Last modified:March 21, 2012 - v2
Checksum:iC819F53515B1BC39
GO
Isoform 2 (identifier: Q92841-1) [UniParc]FASTAAdd to basket
Also known as: p72

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.

Note: Produced by alternative initiation at Met-80 of isoform 1.
Show »
Length:650
Mass (Da):72,371
Checksum:iE58AA249D23F66F3
GO
Isoform 3 (identifier: Q92841-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     482-482: L → LGL

Note: Produced by alternative splicing of isoform 2. No experimental confirmation available.
Show »
Length:652
Mass (Da):72,542
Checksum:i71E89198BBDBF2E6
GO
Isoform 4 (identifier: Q92841-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-79: Missing.
     562-562: G → GKG

Note: Produced by alternative splicing of isoform 2. No experimental confirmation available.
Show »
Length:652
Mass (Da):72,557
Checksum:i05DFD042E4268F2C
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0425271 – 79Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST79
Alternative sequenceiVSP_042528482L → LGL in isoform 3. 1 Publication1
Alternative sequenceiVSP_042529562G → GKG in isoform 4. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59321 mRNA. Translation: AAC50787.1.
CR456432 mRNA. Translation: CAG30318.1.
AL713763 mRNA. Translation: CAH10627.2.
Z97056 Genomic DNA. Translation: CAQ08924.1.
Z97056 Genomic DNA. Translation: CAB09792.1.
CH471095 Genomic DNA. Translation: EAW60243.1.
BC000595 mRNA. Translation: AAH00595.2.
CCDSiCCDS33646.1. [Q92841-4]
PIRiS72367.
RefSeqiNP_006377.2. NM_006386.4. [Q92841-4]
UniGeneiHs.528305.
Hs.706116.

Genome annotation databases

EnsembliENST00000403230; ENSP00000385536; ENSG00000100201.
GeneIDi10521.
KEGGihsa:10521.
UCSCiuc062efu.1. human. [Q92841-4]

Keywords - Coding sequence diversityi

Alternative initiation, Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U59321 mRNA. Translation: AAC50787.1.
CR456432 mRNA. Translation: CAG30318.1.
AL713763 mRNA. Translation: CAH10627.2.
Z97056 Genomic DNA. Translation: CAQ08924.1.
Z97056 Genomic DNA. Translation: CAB09792.1.
CH471095 Genomic DNA. Translation: EAW60243.1.
BC000595 mRNA. Translation: AAH00595.2.
CCDSiCCDS33646.1. [Q92841-4]
PIRiS72367.
RefSeqiNP_006377.2. NM_006386.4. [Q92841-4]
UniGeneiHs.528305.
Hs.706116.

3D structure databases

ProteinModelPortaliQ92841.
SMRiQ92841.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115776. 154 interactors.
DIPiDIP-29843N.
IntActiQ92841. 78 interactors.
MINTiMINT-4545892.
STRINGi9606.ENSP00000380033.

PTM databases

iPTMnetiQ92841.
PhosphoSitePlusiQ92841.
SwissPalmiQ92841.

Polymorphism and mutation databases

BioMutaiDDX17.

2D gel databases

REPRODUCTION-2DPAGEIPI00023785.

Proteomic databases

EPDiQ92841.
MaxQBiQ92841.
PaxDbiQ92841.
PeptideAtlasiQ92841.
PRIDEiQ92841.
TopDownProteomicsiQ92841-1. [Q92841-1]
Q92841-4. [Q92841-4]

Protocols and materials databases

DNASUi10521.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000403230; ENSP00000385536; ENSG00000100201.
GeneIDi10521.
KEGGihsa:10521.
UCSCiuc062efu.1. human. [Q92841-4]

Organism-specific databases

CTDi10521.
DisGeNETi10521.
GeneCardsiDDX17.
HGNCiHGNC:2740. DDX17.
HPAiCAB024908.
HPA063142.
MIMi608469. gene.
neXtProtiNX_Q92841.
PharmGKBiPA27206.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0331. Eukaryota.
COG0513. LUCA.
HOGENOMiHOG000268804.
HOVERGENiHBG015893.
InParanoidiQ92841.
KOiK13178.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100201-MONOMER.
SIGNORiQ92841.

Miscellaneous databases

ChiTaRSiDDX17. human.
GeneWikiiDDX17.
GenomeRNAii10521.
PROiQ92841.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100201.
CleanExiHS_DDX17.
ExpressionAtlasiQ92841. baseline and differential.
GenevisibleiQ92841. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PfamiPF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
SMARTiSM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX17_HUMAN
AccessioniPrimary (citable) accession number: Q92841
Secondary accession number(s): B1AHM0, Q69YT1, Q6ICD6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: March 21, 2012
Last modified: November 30, 2016
This is version 176 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.