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Protein

Probable ATP-dependent RNA helicase DDX17

Gene

DDX17

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

As an RNA helicase, unwinds RNA and alters RNA structures through ATP binding and hydrolysis. Involved in multiple cellular processes, including pre-mRNA splicing, alternative splicing, ribosomal RNA processing and miRNA processing, as well as transcription regulation. Regulates the alternative splicing of exons exhibiting specific features (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). For instance, promotes the inclusion of AC-rich alternative exons in CD44 transcripts (PubMed:12138182). This function requires the RNA helicase activity (PubMed:12138182, PubMed:23022728, PubMed:24910439, PubMed:22266867). Affects NFAT5 and histone macro-H2A.1/H2AFY alternative splicing in a CDK9-dependent manner (PubMed:26209609, PubMed:22266867). In NFAT5, promotes the introduction of alternative exon 4, which contains 2 stop codons and may target NFAT5 exon 4-containing transcripts to nonsense-mediated mRNA decay, leading to the down-regulation of NFAT5 protein (PubMed:22266867). Affects splicing of mediators of steroid hormone signaling pathway, including kinases that phosphorylates ESR1, such as CDK2, MAPK1 and GSK3B, and transcriptional regulators, such as CREBBP, MED1, NCOR1 and NCOR2. By affecting GSK3B splicing, participates in ESR1 and AR stabilization (PubMed:24275493). In myoblasts and epithelial cells, cooperates with HNRNPH1 to control the splicing of specific subsets of exons (PubMed:24910439). In addition to binding mature mRNAs, also interacts with certain pri-microRNAs, including MIR663/miR-663a, MIR99B/miR-99b, and MIR6087/miR-6087 (PubMed:25126784). Binds pri-microRNAs on the 3' segment flanking the stem loop via the 5'-[ACG]CAUC[ACU]-3' consensus sequence (PubMed:24581491). Required for the production of subsets of microRNAs, including MIR21 and MIR125B1 (PubMed:24581491, PubMed:27478153). May be involved not only in microRNA primary transcript processing, but also stabilization (By similarity). Participates in MYC down-regulation at high cell density through the production of MYC-targeting microRNAs (PubMed:24581491). Along with DDX5, may be involved in the processing of the 32S intermediate into the mature 28S ribosomal RNA (PubMed:17485482). Promoter-specific transcription regulator, functioning as a coactivator or corepressor depending on the context of the promoter and the transcriptional complex in which it exists (PubMed:15298701). Enhances NFAT5 transcriptional activity (PubMed:22266867). Synergizes with TP53 in the activation of the MDM2 promoter; this activity requires acetylation on lysine residues (PubMed:17226766, PubMed:20663877, PubMed:19995069). May also coactivate MDM2 transcription through a TP53-independent pathway (PubMed:17226766). Coactivates MMP7 transcription (PubMed:17226766). Along with CTNNB1, coactivates MYC, JUN, FOSL1 and cyclin D1/CCND1 transcription (PubMed:17699760). Alone or in combination with DDX5 and/or SRA1 non-coding RNA, plays a critical role in promoting the assembly of proteins required for the formation of the transcription initiation complex and chromatin remodeling leading to coactivation of MYOD1-dependent transcription. This helicase-independent activity is required for skeletal muscle cells to properly differentiate into myotubes (PubMed:17011493, PubMed:24910439). During epithelial-to-mesenchymal transition, coregulates SMAD-dependent transcriptional activity, directly controlling key effectors of differentiation, including miRNAs which in turn directly repress its expression (PubMed:24910439). Plays a role in estrogen and testosterone signaling pathway at several levels. Mediates the use of alternative promoters in estrogen-responsive genes and regulates transcription and splicing of a large number of steroid hormone target genes (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069). Contrary to splicing regulation activity, transcriptional coregulation of the estrogen receptor ESR1 is helicase-independent (PubMed:19718048, PubMed:24275493). Plays a role in innate immunity. Specifically restricts bunyavirus infection, including Rift Valley fever virus (RVFV) or La Crosse virus (LACV), but not vesicular stomatitis virus (VSV), in an interferon- and DROSHA-independent manner (PubMed:25126784). Binds to RVFV RNA, likely via structured viral RNA elements (PubMed:25126784). Promotes mRNA degradation mediated by the antiviral zinc-finger protein ZC3HAV1, in an ATPase-dependent manner (PubMed:18334637).By similarityCurated19 Publications

Catalytic activityi

ATP + H2O = ADP + phosphate.1 Publication

Kineticsi

  1. KM=170 µM for ATP1 Publication

    Regions

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Nucleotide bindingi215 – 222ATPPROSITE-ProRule annotation8

    GO - Molecular functioni

    • ATP binding Source: UniProtKB-KW
    • ATP-dependent RNA helicase activity Source: GO_Central
    • estrogen receptor binding Source: UniProtKB
    • RNA binding Source: UniProtKB
    • RNA-dependent ATPase activity Source: ProtInc
    • RNA helicase activity Source: ProtInc
    • transcription coactivator activity Source: UniProtKB

    GO - Biological processi

    • alternative mRNA splicing, via spliceosome Source: UniProtKB
    • androgen receptor signaling pathway Source: UniProtKB
    • defense response to virus Source: UniProtKB-KW
    • epithelial to mesenchymal transition Source: UniProtKB
    • gene silencing by RNA Source: UniProtKB-KW
    • intracellular estrogen receptor signaling pathway Source: UniProtKB
    • miRNA metabolic process Source: UniProtKB
    • myoblast differentiation Source: UniProtKB
    • positive regulation of intracellular estrogen receptor signaling pathway Source: UniProtKB
    • positive regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    • regulation of alternative mRNA splicing, via spliceosome Source: UniProtKB
    • regulation of skeletal muscle cell differentiation Source: UniProtKB
    • regulation of transcription from RNA polymerase II promoter Source: UniProtKB
    • RNA processing Source: ProtInc
    • RNA secondary structure unwinding Source: GO_Central
    • rRNA processing Source: UniProtKB-KW
    • transcription, DNA-templated Source: UniProtKB-KW

    Keywordsi

    Molecular functionHelicase, Hydrolase, RNA-binding
    Biological processAntiviral defense, Immunity, mRNA processing, mRNA splicing, RNA-mediated gene silencing, rRNA processing, Transcription, Transcription regulation
    LigandATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SIGNORiQ92841.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Probable ATP-dependent RNA helicase DDX17 (EC:3.6.4.13)
    Alternative name(s):
    DEAD box protein 17
    DEAD box protein p72
    DEAD box protein p821 Publication
    RNA-dependent helicase p72
    Gene namesi
    Name:DDX17
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    Proteomesi
    • UP000005640 Componenti: Chromosome 22

    Organism-specific databases

    HGNCiHGNC:2740. DDX17.

    Subcellular locationi

    GO - Cellular componenti

    • cytosol Source: UniProtKB-SubCell
    • membrane Source: UniProtKB
    • nuclear speck Source: HPA
    • nucleolus Source: UniProtKB-SubCell
    • nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Mutagenesisi108 – 109KK → RR: No effect on HDAC1-, HDAC2- nor HDAC3-binding, small decrease in ESR1 coactivation, decreased TP53 coactivation. Complete loss of lysine acetylation, decreased stability, loss of ESR1 and TP53 coactivation and loss of HDAC1- and HDAC3-binding, no effect on HDAC2-binding; when associated with R-121. 1 Publication2
    Mutagenesisi121K → R: No effect on HDAC1-, HDAC2- nor HDAC3-binding, decreased ESR1 coactivation, strongly decreased TP53 coactivation. Complete loss of lysine acetylation, decreased stability, loss of ESR1 and TP53 coactivation and loss of HDAC1- and HDAC3-binding, no effect on HDAC2-binding; when associated with 108-R-R-109. 1 Publication1
    Mutagenesisi129K → R: Impaired sumoylation and decreased stability. Impairs interaction with HDAC1, but not with HDAC2, nor HDAC3. No effect on EP300-, ESR1-, DDX5- and YAP1-binding. 2 Publications1
    Mutagenesisi221K → N: No effect on transcription activation, when assayed in luciferase reporter gene assays using MDM2 or FOS promoters, either alone or in the presence of EP300 and KAT2B. 1 Publication1
    Mutagenesisi221K → R: Loss of helicase activity. Loss of splicing regulation in the estrogen signaling pathway. Reduced CD44 alternative splicing regulation. Does not promote ZCH3HAV1-mediated RNA degradation. 3 Publications1
    Mutagenesisi222T → A: Decreased CD44 alternative splicing. 1 Publication1
    Mutagenesisi325D → N: Loss of helicase activity. No effect on ESR1 coactivation. 1 Publication1
    Mutagenesisi328D → H: Small decrease in CD44 alternative splicing. 1 Publication1
    Mutagenesisi355W → G: Small decrease in CD44 alternative splicing. 1 Publication1
    Mutagenesisi356S → L: Small decrease in CD44 alternative splicing. 1 Publication1

    Organism-specific databases

    DisGeNETi10521.
    PharmGKBiPA27206.

    Polymorphism and mutation databases

    BioMutaiDDX17.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    ChainiPRO_00000549931 – 729Probable ATP-dependent RNA helicase DDX17Add BLAST729

    Amino acid modifications

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Modified residuei64PhosphoserineCombined sources1
    Modified residuei108N6-acetyllysine; by EP3001 Publication1
    Modified residuei109N6-acetyllysine; by EP3001 Publication1
    Modified residuei121N6-acetyllysine; by EP3001 Publication1
    Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO); alternate
    Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO1); alternateCombined sources1 Publication
    Cross-linki129Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
    Modified residuei523PhosphothreonineCombined sources1
    Modified residuei684Omega-N-methylarginineCombined sources1

    Post-translational modificationi

    Sumoylation significantly increases stability. It also promotes interaction specifically with HDAC1 (but not HDAC2, nor HDAC3) and strongly stimulates ESR1 and TP53 coactivation.1 Publication
    Acetylation at lysine residues stabilizes the protein, stimulates interaction with HDAC1 and HDAC3, but not HDAC2, and represses ESR1 and TP53 coactivation activity.1 Publication

    Keywords - PTMi

    Acetylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

    Proteomic databases

    EPDiQ92841.
    MaxQBiQ92841.
    PaxDbiQ92841.
    PeptideAtlasiQ92841.
    PRIDEiQ92841.
    TopDownProteomicsiQ92841-1. [Q92841-1]
    Q92841-4. [Q92841-4]

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00023785.

    PTM databases

    iPTMnetiQ92841.
    PhosphoSitePlusiQ92841.
    SwissPalmiQ92841.

    Expressioni

    Tissue specificityi

    Widely expressed (PubMed:8871553). Low expression, if any, in normal colonic epithelial cells (at protein level). Levels tend to increase during colon cancer progression, from very low in benign hyperplastic polyps to very high in tubular and villous adenomas (PubMed:17699760).2 Publications

    Gene expression databases

    BgeeiENSG00000100201.
    CleanExiHS_DDX17.
    ExpressionAtlasiQ92841. baseline and differential.
    GenevisibleiQ92841. HS.

    Organism-specific databases

    HPAiCAB024908.
    HPA063142.

    Interactioni

    Subunit structurei

    Interacts with DDX5 in an RNA-independent manner (PubMed:12595555, PubMed:19995069). Interacts with CDK9 transcription elongation complex under basal conditions. Following cell stimulation with poly(I:C), a synthetic double-stranded RNA mimicking viral infection, the interaction with CDK9 is decreased (PubMed:26209609). Interacts with ESR1 in an estrogen-independent manner (PubMed:19718048, PubMed:20663877). Interacts with HNRNPH1; this interaction is important for the regulation of alternative splicing on G-quadruplex structures (PubMed:24910439). At high, but not low, cell density, interacts with DROSHA and DGCR8, the core components of the microprocessor complex involved in the maturation of primary microRNAs (pri-miRNAs) into pre-miRNAs. The interaction with DGCR8 is reduced during mitosis (PubMed:24589731, PubMed:24581491). At low, but not high, cell density, interacts with YAP1 and with its paralog, WWTR1/TAZ. Interactions with DROSHA and YAP1 are mutually exclusive (PubMed:24581491). In vitro, the pre-miRNA processing activity of the DDX17-containing microprocessor complex is weaker than that of the DROSHA/DGCR8 microprocessor complex devoid of DDX17 (PubMed:15531877). Interacts with UPF3B (PubMed:23788676). Interacts with NFAT5; this interaction leads to DDX17 recruitment to LNC2 and S100A4 promoters and NFAT5-mediated DDX17-enhanced transactivation (PubMed:22266867). Interacts with HDAC1, HDAC2 and HDAC3; this interaction with HDAC1 and HDAC3, but not HDAC2, depends upon DDX17 acetylation (PubMed:15298701, PubMed:20663877). Interacts with ZC3HAV1 (via N-terminal domain) in an RNA-independent manner. Interacts with EXOSC3/RRP40 and EXOSC5/RRP46; this interaction may be indirect and mediated by ZC3HAV1-binding (PubMed:18334637). Interacts with EP300; this interaction leads to acetylation at lysine residues (PubMed:17226766, PubMed:19995069). Interacts with CREBBP/CBP and KAT2B/P/CAF (PubMed:17226766). Directly interacts with CTNNB1 (PubMed:17699760). Interacts with MYOD1 (PubMed:17011493). Interacts with TP53 (PubMed:15660129). Interacts with DCP1A in an RNA-independent manner. Interacts with DCP2 in an RNA-dependent manner (PubMed:21876179).18 Publications

    Binary interactionsi

    Show more details

    GO - Molecular functioni

    • estrogen receptor binding Source: UniProtKB

    Protein-protein interaction databases

    BioGridi115776. 155 interactors.
    DIPiDIP-29843N.
    IntActiQ92841. 82 interactors.
    MINTiMINT-4545892.
    STRINGi9606.ENSP00000380033.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92841.
    SMRiQ92841.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Domaini202 – 377Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST176
    Domaini405 – 552Helicase C-terminalPROSITE-ProRule annotationAdd BLAST148

    Region

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Regioni547 – 729Transactivation domainAdd BLAST183
    Regioni718 – 726Interaction with YAP11 Publication9

    Motif

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Motifi171 – 199Q motifAdd BLAST29
    Motifi325 – 328DEAD box4

    Compositional bias

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Compositional biasi101 – 104Poly-Gly4
    Compositional biasi556 – 563Poly-Gly8
    Compositional biasi718 – 726Poly-Pro9

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiKOG0331. Eukaryota.
    COG0513. LUCA.
    HOGENOMiHOG000268804.
    HOVERGENiHBG015893.
    InParanoidiQ92841.
    KOiK13178.

    Family and domain databases

    InterProiView protein in InterPro
    IPR011545. DEAD/DEAH_box_helicase_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    PfamiView protein in Pfam
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    SMARTiView protein in SMART
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiView protein in PROSITE
    PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.

    Sequences (4)i

    Sequence statusi: Complete.

    This entry describes 4 isoformsi produced by alternative splicing and alternative initiation. AlignAdd to basket

    Isoform 1 (identifier: Q92841-4) [UniParc]FASTAAdd to basket
    Also known as: p82

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

            10         20         30         40         50
    MPTGFVAPIL CVLLPSPTRE AATVASATGD SASERESAAP AAAPTAEAPP
    60 70 80 90 100
    PSVVTRPEPQ ALPSPAIRAP LPDLYPFGTM RGGGFGDRDR DRDRGGFGAR
    110 120 130 140 150
    GGGGLPPKKF GNPGERLRKK KWDLSELPKF EKNFYVEHPE VARLTPYEVD
    160 170 180 190 200
    ELRRKKEITV RGGDVCPKPV FAFHHANFPQ YVMDVLMDQH FTEPTPIQCQ
    210 220 230 240 250
    GFPLALSGRD MVGIAQTGSG KTLAYLLPAI VHINHQPYLE RGDGPICLVL
    260 270 280 290 300
    APTRELAQQV QQVADDYGKC SRLKSTCIYG GAPKGPQIRD LERGVEICIA
    310 320 330 340 350
    TPGRLIDFLE SGKTNLRRCT YLVLDEADRM LDMGFEPQIR KIVDQIRPDR
    360 370 380 390 400
    QTLMWSATWP KEVRQLAEDF LRDYTQINVG NLELSANHNI LQIVDVCMES
    410 420 430 440 450
    EKDHKLIQLM EEIMAEKENK TIIFVETKRR CDDLTRRMRR DGWPAMCIHG
    460 470 480 490 500
    DKSQPERDWV LNEFRSGKAP ILIATDVASR GLDVEDVKFV INYDYPNSSE
    510 520 530 540 550
    DYVHRIGRTA RSTNKGTAYT FFTPGNLKQA RELIKVLEEA NQAINPKLMQ
    560 570 580 590 600
    LVDHRGGGGG GGGRSRYRTT SSANNPNLMY QDECDRRLRG VKDGGRRDSA
    610 620 630 640 650
    SYRDRSETDR AGYANGSGYG SPNSAFGAQA GQYTYGQGTY GAAAYGTSSY
    660 670 680 690 700
    TAQEYGAGTY GASSTTSTGR SSQSSSQQFS GIGRSGQQPQ PLMSQQFAQP
    710 720
    PGATNMIGYM GQTAYQYPPP PPPPPPSRK
    Note: Starts at an alternative CUG codon.
    Length:729
    Mass (Da):80,272
    Last modified:March 21, 2012 - v2
    Checksum:iC819F53515B1BC39
    GO
    Isoform 2 (identifier: Q92841-1) [UniParc]FASTAAdd to basket
    Also known as: p72

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.

    Note: Produced by alternative initiation at Met-80 of isoform 1.
    Show »
    Length:650
    Mass (Da):72,371
    Checksum:iE58AA249D23F66F3
    GO
    Isoform 3 (identifier: Q92841-2) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.
         482-482: L → LGL

    Note: Produced by alternative splicing of isoform 2. No experimental confirmation available.
    Show »
    Length:652
    Mass (Da):72,542
    Checksum:i71E89198BBDBF2E6
    GO
    Isoform 4 (identifier: Q92841-3) [UniParc]FASTAAdd to basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-79: Missing.
         562-562: G → GKG

    Note: Produced by alternative splicing of isoform 2. No experimental confirmation available.
    Show »
    Length:652
    Mass (Da):72,557
    Checksum:i05DFD042E4268F2C
    GO

    Alternative sequence

    Feature keyPosition(s)DescriptionActionsGraphical viewLength
    Alternative sequenceiVSP_0425271 – 79Missing in isoform 2, isoform 3 and isoform 4. 3 PublicationsAdd BLAST79
    Alternative sequenceiVSP_042528482L → LGL in isoform 3. 1 Publication1
    Alternative sequenceiVSP_042529562G → GKG in isoform 4. 1 Publication1

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U59321 mRNA. Translation: AAC50787.1.
    CR456432 mRNA. Translation: CAG30318.1.
    AL713763 mRNA. Translation: CAH10627.2.
    Z97056 Genomic DNA. No translation available.
    CH471095 Genomic DNA. Translation: EAW60243.1.
    BC000595 mRNA. Translation: AAH00595.2.
    CCDSiCCDS33646.1. [Q92841-4]
    PIRiS72367.
    RefSeqiNP_006377.2. NM_006386.4. [Q92841-4]
    UniGeneiHs.528305.
    Hs.706116.

    Genome annotation databases

    EnsembliENST00000403230; ENSP00000385536; ENSG00000100201.
    GeneIDi10521.
    KEGGihsa:10521.
    UCSCiuc062efu.1. human. [Q92841-4]

    Keywords - Coding sequence diversityi

    Alternative initiation, Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBLi
    GenBanki
    DDBJi
    Links Updated
    U59321 mRNA. Translation: AAC50787.1.
    CR456432 mRNA. Translation: CAG30318.1.
    AL713763 mRNA. Translation: CAH10627.2.
    Z97056 Genomic DNA. No translation available.
    CH471095 Genomic DNA. Translation: EAW60243.1.
    BC000595 mRNA. Translation: AAH00595.2.
    CCDSiCCDS33646.1. [Q92841-4]
    PIRiS72367.
    RefSeqiNP_006377.2. NM_006386.4. [Q92841-4]
    UniGeneiHs.528305.
    Hs.706116.

    3D structure databases

    ProteinModelPortaliQ92841.
    SMRiQ92841.
    ModBaseiSearch...
    MobiDBiSearch...

    Protein-protein interaction databases

    BioGridi115776. 155 interactors.
    DIPiDIP-29843N.
    IntActiQ92841. 82 interactors.
    MINTiMINT-4545892.
    STRINGi9606.ENSP00000380033.

    PTM databases

    iPTMnetiQ92841.
    PhosphoSitePlusiQ92841.
    SwissPalmiQ92841.

    Polymorphism and mutation databases

    BioMutaiDDX17.

    2D gel databases

    REPRODUCTION-2DPAGEiIPI00023785.

    Proteomic databases

    EPDiQ92841.
    MaxQBiQ92841.
    PaxDbiQ92841.
    PeptideAtlasiQ92841.
    PRIDEiQ92841.
    TopDownProteomicsiQ92841-1. [Q92841-1]
    Q92841-4. [Q92841-4]

    Protocols and materials databases

    DNASUi10521.
    Structural Biology KnowledgebaseSearch...

    Genome annotation databases

    EnsembliENST00000403230; ENSP00000385536; ENSG00000100201.
    GeneIDi10521.
    KEGGihsa:10521.
    UCSCiuc062efu.1. human. [Q92841-4]

    Organism-specific databases

    CTDi10521.
    DisGeNETi10521.
    GeneCardsiDDX17.
    HGNCiHGNC:2740. DDX17.
    HPAiCAB024908.
    HPA063142.
    MIMi608469. gene.
    neXtProtiNX_Q92841.
    PharmGKBiPA27206.
    GenAtlasiSearch...

    Phylogenomic databases

    eggNOGiKOG0331. Eukaryota.
    COG0513. LUCA.
    HOGENOMiHOG000268804.
    HOVERGENiHBG015893.
    InParanoidiQ92841.
    KOiK13178.

    Enzyme and pathway databases

    SIGNORiQ92841.

    Miscellaneous databases

    ChiTaRSiDDX17. human.
    GeneWikiiDDX17.
    GenomeRNAii10521.
    PROiPR:Q92841.
    SOURCEiSearch...

    Gene expression databases

    BgeeiENSG00000100201.
    CleanExiHS_DDX17.
    ExpressionAtlasiQ92841. baseline and differential.
    GenevisibleiQ92841. HS.

    Family and domain databases

    InterProiView protein in InterPro
    IPR011545. DEAD/DEAH_box_helicase_dom.
    IPR014001. Helicase_ATP-bd.
    IPR001650. Helicase_C.
    IPR027417. P-loop_NTPase.
    IPR000629. RNA-helicase_DEAD-box_CS.
    IPR014014. RNA_helicase_DEAD_Q_motif.
    PfamiView protein in Pfam
    PF00270. DEAD. 1 hit.
    PF00271. Helicase_C. 1 hit.
    SMARTiView protein in SMART
    SM00487. DEXDc. 1 hit.
    SM00490. HELICc. 1 hit.
    SUPFAMiSSF52540. SSF52540. 1 hit.
    PROSITEiView protein in PROSITE
    PS00039. DEAD_ATP_HELICASE. 1 hit.
    PS51192. HELICASE_ATP_BIND_1. 1 hit.
    PS51194. HELICASE_CTER. 1 hit.
    PS51195. Q_MOTIF. 1 hit.
    ProtoNetiSearch...

    Entry informationi

    Entry nameiDDX17_HUMAN
    AccessioniPrimary (citable) accession number: Q92841
    Secondary accession number(s): B1AHM0
    , H3BLZ8, Q69YT1, Q6ICD6
    Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: March 21, 2012
    Last modified: May 10, 2017
    This is version 181 of the entry and version 2 of the sequence. See complete history.
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    Was reported to act as a transcriptional coactivator for estrogen receptor ESR1 (PubMed:11250900). Although this publication was retracted because of aberrations in some figures, this function was also described in other publications by different groups and may be real (PubMed:24275493, PubMed:20406972, PubMed:20663877, PubMed:19995069).5 Publications

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 22
      Human chromosome 22: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    Similar proteinsi

    Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
    100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
    90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
    50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.