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Q92839

- HYAS1_HUMAN

UniProt

Q92839 - HYAS1_HUMAN

Protein

Hyaluronan synthase 1

Gene

HAS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 125 (01 Oct 2014)
      Sequence version 2 (14 Oct 2008)
      Previous versions | rss
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    Functioni

    Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate By similarity.By similarity

    Catalytic activityi

    UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).
    UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).

    Cofactori

    Magnesium.

    Pathwayi

    GO - Molecular functioni

    1. hyaluronan synthase activity Source: UniProtKB

    GO - Biological processi

    1. carbohydrate metabolic process Source: Reactome
    2. cell adhesion Source: ProtInc
    3. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
    4. extracellular matrix assembly Source: UniProtKB
    5. extracellular polysaccharide biosynthetic process Source: UniProtKB
    6. glycosaminoglycan biosynthetic process Source: ProtInc
    7. glycosaminoglycan metabolic process Source: Reactome
    8. hyaluronan biosynthetic process Source: Reactome
    9. hyaluronan metabolic process Source: Reactome
    10. negative regulation of fibroblast migration Source: UniProtKB
    11. small molecule metabolic process Source: Reactome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    BRENDAi2.4.1.212. 2681.
    ReactomeiREACT_121301. Hyaluronan biosynthesis and export.
    UniPathwayiUPA00341.

    Protein family/group databases

    CAZyiGT2. Glycosyltransferase Family 2.
    TCDBi4.D.1.2.1. the putative vectorial glycosyl polymerization (vgp) family.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Hyaluronan synthase 1 (EC:2.4.1.212)
    Alternative name(s):
    Hyaluronate synthase 1
    Hyaluronic acid synthase 1
    Short name:
    HA synthase 1
    Short name:
    HuHAS1
    Gene namesi
    Name:HAS1
    Synonyms:HAS
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:4818. HAS1.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of plasma membrane Source: ProtInc
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29194.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 578578Hyaluronan synthase 1PRO_0000197169Add
    BLAST

    Proteomic databases

    PaxDbiQ92839.
    PRIDEiQ92839.

    PTM databases

    PhosphoSiteiQ92839.

    Expressioni

    Tissue specificityi

    Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.1 Publication

    Gene expression databases

    ArrayExpressiQ92839.
    BgeeiQ92839.
    CleanExiHS_HAS1.
    GenevestigatoriQ92839.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    EIF6P565371EBI-1052423,EBI-372243
    VHLP403371EBI-1052423,EBI-301246

    Protein-protein interaction databases

    BioGridi109286. 4 interactions.
    STRINGi9606.ENSP00000222115.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92839.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2525CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini47 – 526ExtracellularSequence Analysis
    Topological domaini74 – 399326CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini421 – 43010ExtracellularSequence Analysis
    Topological domaini452 – 4576CytoplasmicSequence Analysis
    Topological domaini479 – 49719ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini519 – 54022CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini562 – 57817ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei400 – 42021Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei431 – 45121Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei458 – 47821Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei498 – 51821Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei541 – 56121Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the NodC/HAS family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG1215.
    HOGENOMiHOG000112847.
    HOVERGENiHBG000189.
    InParanoidiQ92839.
    KOiK00752.
    PhylomeDBiQ92839.
    TreeFamiTF332506.

    Family and domain databases

    Gene3Di3.90.550.10. 2 hits.
    InterProiIPR026107. HAS/NodC.
    IPR028385. HAS1.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view]
    PANTHERiPTHR22913. PTHR22913. 1 hit.
    PTHR22913:SF4. PTHR22913:SF4. 1 hit.
    SUPFAMiSSF53448. SSF53448. 2 hits.

    Sequencei

    Sequence statusi: Complete.

    Q92839-1 [UniParc]FASTAAdd to Basket

    « Hide

    MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR    50
    YGLLAFGLYG AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT 100
    ISAYQEDPAY LRQCLASARA LLYPRARLRV LMVVDGNRAE DLYMVDMFRE 150
    VFADEDPATY VWDGNYHQPW EPAAAGAVGA GAYREVEAED PGRLAVEALV 200
    RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT RLDPMALLEL 250
    VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH 300
    CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG 350
    YATKYTSRSR CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW 400
    MTYEAVVSGL FPFFVAATVL RLFYAGRPWA LLWVLLCVQG VALAKAAFAA 450
    WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL VTMNQSGWGT SGRRKLAANY 500
    VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH LAAGAGAYVG 550
    YWVAMLTLYW VGVRRLCRRR TGGYRVQV 578
    Length:578
    Mass (Da):64,832
    Last modified:October 14, 2008 - v2
    Checksum:i2FE3A44B0D5380FF
    GO

    Sequence cautioni

    The sequence BAA12351.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti1 – 22MR → RS in BAA12351. (PubMed:8651928)Curated
    Sequence conflicti34 – 341G → A in BAA12351. (PubMed:8651928)Curated
    Sequence conflicti128 – 1281L → V in BAA12351. (PubMed:8651928)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti14 – 141C → R.2 Publications
    Corresponds to variant rs7248778 [ dbSNP | Ensembl ].
    VAR_047025

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84424 mRNA. Translation: BAA12351.1. Different initiation.
    U59269 mRNA. Translation: AAC50706.1.
    AC018755 Genomic DNA. Translation: AAF87845.1.
    CH471135 Genomic DNA. Translation: EAW72038.1.
    CCDSiCCDS12838.1.
    PIRiJC4812.
    RefSeqiNP_001514.2. NM_001523.2.
    UniGeneiHs.57697.

    Genome annotation databases

    EnsembliENST00000222115; ENSP00000222115; ENSG00000105509.
    GeneIDi3036.
    KEGGihsa:3036.
    UCSCiuc002pxn.1. human.

    Polymorphism databases

    DMDMi209572627.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D84424 mRNA. Translation: BAA12351.1 . Different initiation.
    U59269 mRNA. Translation: AAC50706.1 .
    AC018755 Genomic DNA. Translation: AAF87845.1 .
    CH471135 Genomic DNA. Translation: EAW72038.1 .
    CCDSi CCDS12838.1.
    PIRi JC4812.
    RefSeqi NP_001514.2. NM_001523.2.
    UniGenei Hs.57697.

    3D structure databases

    ProteinModelPortali Q92839.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109286. 4 interactions.
    STRINGi 9606.ENSP00000222115.

    Protein family/group databases

    CAZyi GT2. Glycosyltransferase Family 2.
    TCDBi 4.D.1.2.1. the putative vectorial glycosyl polymerization (vgp) family.

    PTM databases

    PhosphoSitei Q92839.

    Polymorphism databases

    DMDMi 209572627.

    Proteomic databases

    PaxDbi Q92839.
    PRIDEi Q92839.

    Protocols and materials databases

    DNASUi 3036.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000222115 ; ENSP00000222115 ; ENSG00000105509 .
    GeneIDi 3036.
    KEGGi hsa:3036.
    UCSCi uc002pxn.1. human.

    Organism-specific databases

    CTDi 3036.
    GeneCardsi GC19M052216.
    HGNCi HGNC:4818. HAS1.
    MIMi 601463. gene.
    neXtProti NX_Q92839.
    PharmGKBi PA29194.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG1215.
    HOGENOMi HOG000112847.
    HOVERGENi HBG000189.
    InParanoidi Q92839.
    KOi K00752.
    PhylomeDBi Q92839.
    TreeFami TF332506.

    Enzyme and pathway databases

    UniPathwayi UPA00341 .
    BRENDAi 2.4.1.212. 2681.
    Reactomei REACT_121301. Hyaluronan biosynthesis and export.

    Miscellaneous databases

    GeneWikii HAS1.
    GenomeRNAii 3036.
    NextBioi 12018.
    PROi Q92839.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92839.
    Bgeei Q92839.
    CleanExi HS_HAS1.
    Genevestigatori Q92839.

    Family and domain databases

    Gene3Di 3.90.550.10. 2 hits.
    InterProi IPR026107. HAS/NodC.
    IPR028385. HAS1.
    IPR029044. Nucleotide-diphossugar_trans.
    [Graphical view ]
    PANTHERi PTHR22913. PTHR22913. 1 hit.
    PTHR22913:SF4. PTHR22913:SF4. 1 hit.
    SUPFAMi SSF53448. SSF53448. 2 hits.
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of human hyaluronan synthase."
      Itano N., Kimata K.
      Biochem. Biophys. Res. Commun. 222:816-820(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-14, TISSUE SPECIFICITY.
      Tissue: Fetal brain.
    2. "Functional cloning of the cDNA for a human hyaluronan synthase."
      Shyjan A.M., Heldin P., Butcher E.C., Yoshino T., Briskin M.J.
      J. Biol. Chem. 271:23395-23399(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-14.
      Tissue: Lymph node.
    3. "The DNA sequence and biology of human chromosome 19."
      Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
      , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
      Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiHYAS1_HUMAN
    AccessioniPrimary (citable) accession number: Q92839
    Secondary accession number(s): Q14470, Q9NS49
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: October 14, 2008
    Last modified: October 1, 2014
    This is version 125 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3