Hyaluronan synthase 1 - Homo sapiens (Human)

Contribute

Send feedback

Read comments (0) or add your own

Reviewed, UniProtKB/Swiss-Prot Q92839 (HAS1_HUMAN)

Last modified July 7, 2009. Version 77. History...

Clusters with 100%, 90%, 50% identity |

Documents (6) |

Third-party data |

Customize display

text xml rdf/xml gff fasta

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Binary interactions · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

Hide | Top

Names and origin

Protein names

Recommended name:
    Hyaluronan synthase 1
    EC=2.4.1.212
Alternative name(s):
    Hyaluronate synthase 1
    Hyaluronic acid synthase 1
      Short name=HA synthase 1
      Short name=HuHAS1

Gene names

Name:	HAS1
Synonyms:	HAS

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Hide | Top

Protein attributes

Sequence length	578 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

Hide | Top

General annotation (Comments)

Function	Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate.
Catalytic activity	UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan). UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).
Cofactor	Magnesium.
Pathway	Glycan biosynthesis; hyaluronan biosynthesis.
Subcellular location	Membrane; Multi-pass membrane protein Probable.
Tissue specificity	Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.
Sequence similarities	Belongs to the nodC/HAS family.

Hide | Top

Ontologies

Keywords
Cellular component	Membrane
Coding sequence diversity	Polymorphism
Domain	Transmembrane
Molecular function	Glycosyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	cell adhesion Ref.2 Traceable author statement. Source: ProtInc glycosaminoglycan biosynthetic process Ref.2 Traceable author statement. Source: ProtInc
Cellular component	integral to plasma membrane Traceable author statement. Source: ProtInc
Molecular function	hyaluronan synthase activity Inferred from electronic annotation. Source: EC protein binding Inferred from physical interaction. Source: IntAct
Complete GO annotation...

Hide | Top

Binary interactions

With	Entry	#Exp.	IntAct	Notes
EIF6	P56537	1	EBI-1052423,EBI-372243
VHL	P40337	1	EBI-1052423,EBI-301246

Hide | Top

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 578

578

Hyaluronan synthase 1

PRO_0000197169

Regions

Topological domain

1 – 25

Cytoplasmic Potential

Transmembrane

26 – 46

1 Potential

Topological domain

47 – 52

Extracellular Potential

Transmembrane

53 – 73

2 Potential

Topological domain

74 – 399

326

Cytoplasmic Potential

Transmembrane

400 – 420

3 Potential

Topological domain

421 – 430

Extracellular Potential

Transmembrane

431 – 451

4 Potential

Topological domain

452 – 457

Cytoplasmic Potential

Transmembrane

458 – 478

5 Potential

Topological domain

479 – 497

Extracellular Potential

Transmembrane

498 – 518

6 Potential

Topological domain

519 – 540

Cytoplasmic Potential

Transmembrane

541 – 561

7 Potential

Topological domain

562 – 578

Extracellular Potential

Natural variations

Natural variant

C → R: dbSNP rs7248778. Ref.1 Ref.2

VAR_047025

Experimental info

Sequence conflict

1 – 2

MR → RS in BAA12351. Ref.1

Sequence conflict

G → A in BAA12351. Ref.1

Sequence conflict

128

L → V in BAA12351. Ref.1

Hide | Top

Sequences

Sequence

Length

Mass (Da)

Tools

Q92839-1 [UniParc].

Last modified October 14, 2008. Version 2.
Checksum: 2FE3A44B0D5380FF
Show »

FASTA

578

64,832

        10         20         30         40         50         60 
MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR YGLLAFGLYG 

        70         80         90        100        110        120 
AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT ISAYQEDPAY LRQCLASARA 

       130        140        150        160        170        180 
LLYPRARLRV LMVVDGNRAE DLYMVDMFRE VFADEDPATY VWDGNYHQPW EPAAAGAVGA 

       190        200        210        220        230        240 
GAYREVEAED PGRLAVEALV RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT 

       250        260        270        280        290        300 
RLDPMALLEL VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH 

       310        320        330        340        350        360 
CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG YATKYTSRSR 

       370        380        390        400        410        420 
CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW MTYEAVVSGL FPFFVAATVL 

       430        440        450        460        470        480 
RLFYAGRPWA LLWVLLCVQG VALAKAAFAA WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL 

       490        500        510        520        530        540 
VTMNQSGWGT SGRRKLAANY VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH 

       550        560        570 
LAAGAGAYVG YWVAMLTLYW VGVRRLCRRR TGGYRVQV

« Hide

Hide | Top

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Molecular cloning of human hyaluronan synthase." Itano N., Kimata K. Biochem. Biophys. Res. Commun. 222:816-820(1996) [PubMed: 8651928] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-14. Tissue: Fetal brain.
[2]	"Functional cloning of the cDNA for a human hyaluronan synthase." Shyjan A.M., Heldin P., Butcher E.C., Yoshino T., Briskin M.J. J. Biol. Chem. 271:23395-23399(1996) [PubMed: 8798544] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-14. Tissue: Lymph node.
[3]	"The DNA sequence and biology of human chromosome 19." Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. Lucas S.M. Nature 428:529-535(2004) [PubMed: 15057824] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Hide | Top

Web resources

GGDB

GlycoGene database

Hide | Top

Cross-references

Sequence databases
	D84424 mRNA. Translation: BAA12351.1. Different initiation. U59269 mRNA. Translation: AAC50706.1. AC018755 Genomic DNA. Translation: AAF87845.1. CH471135 Genomic DNA. Translation: EAW72038.1.
IPI	IPI00023768.
PIR	JC4812.
RefSeq	NP_001514.2.
UniGene	Hs.57697
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92839. 2 interactions.
Protein family/group databases
CAZy	GT2. Glycosyltransferase Family 2.
PTM databases
PhosphoSite	Q92839.
Proteomic databases
PRIDE	Q92839.
Genome annotation databases
Ensembl	ENSG00000105509. Homo sapiens. [Contig view]
GeneID	3036.
KEGG	hsa:3036.
Organism-specific databases
GeneCards	GC19M056908.
H-InvDB	HIX0027518.
HGNC	HGNC:4818. HAS1.
MIM	601463. gene.
PharmGKB	PA29194.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q92839.
HOVERGEN	Q92839.
OMA	Q92839. QSGWGTS.
Enzyme and pathway databases
BRENDA	2.4.1.212. 247.
Gene expression databases
ArrayExpress	Q92839.
Bgee	Q92839.
CleanEx	HS_HAS1.
GermOnline	ENSG00000105509. Homo sapiens.
Family and domain databases
InterPro	IPR001173. Glyco_trans_2. [Graphical view]
Pfam	PF00535. Glycos_transf_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	12018.
SOURCE	Search...

Hide | Top

Entry information

Entry name

HAS1_HUMAN

Accession

Primary (citable) accession number: Q92839
Secondary accession number(s): Q14470, Q9NS49

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	October 14, 2008
Last modified:	July 7, 2009
This is version 77 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Hide | Top

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Binary interactions

With

Entry

#Exp.

IntAct

Notes

Sequence annotation (Features)

Molecule processing

Regions

Natural variations

Experimental info

Sequences

References

Web resources

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

Protein family/group databases

PTM databases

Proteomic databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Gene expression databases

Family and domain databases

Other Resources

Entry information

Relevant documents