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Q92839

- HYAS1_HUMAN

UniProt

Q92839 - HYAS1_HUMAN

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Protein

Hyaluronan synthase 1

Gene

HAS1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).By similarity

Catalytic activityi

UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).

Cofactori

Magnesium.

Pathwayi

GO - Molecular functioni

  1. hyaluronan synthase activity Source: UniProtKB

GO - Biological processi

  1. carbohydrate metabolic process Source: Reactome
  2. cell adhesion Source: ProtInc
  3. cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  4. extracellular matrix assembly Source: UniProtKB
  5. extracellular polysaccharide biosynthetic process Source: UniProtKB
  6. glycosaminoglycan biosynthetic process Source: ProtInc
  7. glycosaminoglycan metabolic process Source: Reactome
  8. hyaluronan biosynthetic process Source: Reactome
  9. hyaluronan metabolic process Source: Reactome
  10. negative regulation of fibroblast migration Source: UniProtKB
  11. small molecule metabolic process Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BRENDAi2.4.1.212. 2681.
ReactomeiREACT_121301. Hyaluronan biosynthesis and export.
UniPathwayiUPA00341.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.
TCDBi4.D.1.2.1. the putative vectorial glycosyl polymerization (vgp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan synthase 1 (EC:2.4.1.212)
Alternative name(s):
Hyaluronate synthase 1
Hyaluronic acid synthase 1
Short name:
HA synthase 1
Short name:
HuHAS1
Gene namesi
Name:HAS1
Synonyms:HAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 19

Organism-specific databases

HGNCiHGNC:4818. HAS1.

Subcellular locationi

GO - Cellular componenti

  1. integral component of plasma membrane Source: ProtInc
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA29194.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 578578Hyaluronan synthase 1PRO_0000197169Add
BLAST

Proteomic databases

PaxDbiQ92839.
PRIDEiQ92839.

PTM databases

PhosphoSiteiQ92839.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.1 Publication

Gene expression databases

BgeeiQ92839.
CleanExiHS_HAS1.
ExpressionAtlasiQ92839. baseline and differential.
GenevestigatoriQ92839.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
EIF6P565371EBI-1052423,EBI-372243
VHLP403371EBI-1052423,EBI-301246

Protein-protein interaction databases

BioGridi109286. 4 interactions.
STRINGi9606.ENSP00000222115.

Structurei

3D structure databases

ProteinModelPortaliQ92839.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2525CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini47 – 526ExtracellularSequence Analysis
Topological domaini74 – 399326CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini421 – 43010ExtracellularSequence Analysis
Topological domaini452 – 4576CytoplasmicSequence Analysis
Topological domaini479 – 49719ExtracellularSequence AnalysisAdd
BLAST
Topological domaini519 – 54022CytoplasmicSequence AnalysisAdd
BLAST
Topological domaini562 – 57817ExtracellularSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei26 – 4621Helical; Name=1Sequence AnalysisAdd
BLAST
Transmembranei53 – 7321Helical; Name=2Sequence AnalysisAdd
BLAST
Transmembranei400 – 42021Helical; Name=3Sequence AnalysisAdd
BLAST
Transmembranei431 – 45121Helical; Name=4Sequence AnalysisAdd
BLAST
Transmembranei458 – 47821Helical; Name=5Sequence AnalysisAdd
BLAST
Transmembranei498 – 51821Helical; Name=6Sequence AnalysisAdd
BLAST
Transmembranei541 – 56121Helical; Name=7Sequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the NodC/HAS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG1215.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
InParanoidiQ92839.
KOiK00752.
PhylomeDBiQ92839.
TreeFamiTF332506.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR026107. HAS/NodC.
IPR028385. HAS1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF4. PTHR22913:SF4. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92839-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR
60 70 80 90 100
YGLLAFGLYG AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT
110 120 130 140 150
ISAYQEDPAY LRQCLASARA LLYPRARLRV LMVVDGNRAE DLYMVDMFRE
160 170 180 190 200
VFADEDPATY VWDGNYHQPW EPAAAGAVGA GAYREVEAED PGRLAVEALV
210 220 230 240 250
RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT RLDPMALLEL
260 270 280 290 300
VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH
310 320 330 340 350
CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG
360 370 380 390 400
YATKYTSRSR CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW
410 420 430 440 450
MTYEAVVSGL FPFFVAATVL RLFYAGRPWA LLWVLLCVQG VALAKAAFAA
460 470 480 490 500
WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL VTMNQSGWGT SGRRKLAANY
510 520 530 540 550
VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH LAAGAGAYVG
560 570
YWVAMLTLYW VGVRRLCRRR TGGYRVQV
Length:578
Mass (Da):64,832
Last modified:October 14, 2008 - v2
Checksum:i2FE3A44B0D5380FF
GO

Sequence cautioni

The sequence BAA12351.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti1 – 22MR → RS in BAA12351. (PubMed:8651928)Curated
Sequence conflicti34 – 341G → A in BAA12351. (PubMed:8651928)Curated
Sequence conflicti128 – 1281L → V in BAA12351. (PubMed:8651928)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti14 – 141C → R.2 Publications
Corresponds to variant rs7248778 [ dbSNP | Ensembl ].
VAR_047025

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84424 mRNA. Translation: BAA12351.1. Different initiation.
U59269 mRNA. Translation: AAC50706.1.
AC018755 Genomic DNA. Translation: AAF87845.1.
CH471135 Genomic DNA. Translation: EAW72038.1.
CCDSiCCDS12838.1.
PIRiJC4812.
RefSeqiNP_001514.2. NM_001523.3.
UniGeneiHs.57697.

Genome annotation databases

EnsembliENST00000222115; ENSP00000222115; ENSG00000105509.
GeneIDi3036.
KEGGihsa:3036.
UCSCiuc002pxn.1. human.

Polymorphism databases

DMDMi209572627.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Web resourcesi

GGDB

GlycoGene database

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D84424 mRNA. Translation: BAA12351.1 . Different initiation.
U59269 mRNA. Translation: AAC50706.1 .
AC018755 Genomic DNA. Translation: AAF87845.1 .
CH471135 Genomic DNA. Translation: EAW72038.1 .
CCDSi CCDS12838.1.
PIRi JC4812.
RefSeqi NP_001514.2. NM_001523.3.
UniGenei Hs.57697.

3D structure databases

ProteinModelPortali Q92839.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109286. 4 interactions.
STRINGi 9606.ENSP00000222115.

Protein family/group databases

CAZyi GT2. Glycosyltransferase Family 2.
TCDBi 4.D.1.2.1. the putative vectorial glycosyl polymerization (vgp) family.

PTM databases

PhosphoSitei Q92839.

Polymorphism databases

DMDMi 209572627.

Proteomic databases

PaxDbi Q92839.
PRIDEi Q92839.

Protocols and materials databases

DNASUi 3036.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000222115 ; ENSP00000222115 ; ENSG00000105509 .
GeneIDi 3036.
KEGGi hsa:3036.
UCSCi uc002pxn.1. human.

Organism-specific databases

CTDi 3036.
GeneCardsi GC19M052216.
HGNCi HGNC:4818. HAS1.
MIMi 601463. gene.
neXtProti NX_Q92839.
PharmGKBi PA29194.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG1215.
GeneTreei ENSGT00390000010337.
HOGENOMi HOG000112847.
HOVERGENi HBG000189.
InParanoidi Q92839.
KOi K00752.
PhylomeDBi Q92839.
TreeFami TF332506.

Enzyme and pathway databases

UniPathwayi UPA00341 .
BRENDAi 2.4.1.212. 2681.
Reactomei REACT_121301. Hyaluronan biosynthesis and export.

Miscellaneous databases

GeneWikii HAS1.
GenomeRNAii 3036.
NextBioi 12018.
PROi Q92839.
SOURCEi Search...

Gene expression databases

Bgeei Q92839.
CleanExi HS_HAS1.
ExpressionAtlasi Q92839. baseline and differential.
Genevestigatori Q92839.

Family and domain databases

Gene3Di 3.90.550.10. 2 hits.
InterProi IPR026107. HAS/NodC.
IPR028385. HAS1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view ]
PANTHERi PTHR22913. PTHR22913. 1 hit.
PTHR22913:SF4. PTHR22913:SF4. 1 hit.
SUPFAMi SSF53448. SSF53448. 2 hits.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of human hyaluronan synthase."
    Itano N., Kimata K.
    Biochem. Biophys. Res. Commun. 222:816-820(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-14, TISSUE SPECIFICITY.
    Tissue: Fetal brain.
  2. "Functional cloning of the cDNA for a human hyaluronan synthase."
    Shyjan A.M., Heldin P., Butcher E.C., Yoshino T., Briskin M.J.
    J. Biol. Chem. 271:23395-23399(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-14.
    Tissue: Lymph node.
  3. "The DNA sequence and biology of human chromosome 19."
    Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V.
    , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
    Nature 428:529-535(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiHYAS1_HUMAN
AccessioniPrimary (citable) accession number: Q92839
Secondary accession number(s): Q14470, Q9NS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: October 29, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3