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Protein

Hyaluronan synthase 1

Gene

HAS1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the addition of GlcNAc or GlcUA monosaccharides to the nascent hyaluronan polymer. Therefore, it is essential to hyaluronan synthesis a major component of most extracellular matrices that has a structural role in tissues architectures and regulates cell adhesion, migration and differentiation. This is one of the isozymes catalyzing that reaction. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate (By similarity).By similarity

Catalytic activityi

UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).
UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).

Cofactori

Pathwayi: hyaluronan biosynthesis

This protein is involved in the pathway hyaluronan biosynthesis, which is part of Glycan biosynthesis.
View all proteins of this organism that are known to be involved in the pathway hyaluronan biosynthesis and in Glycan biosynthesis.

GO - Molecular functioni

GO - Biological processi

  • cell adhesion Source: ProtInc
  • cellular response to platelet-derived growth factor stimulus Source: UniProtKB
  • estrous cycle Source: Ensembl
  • extracellular matrix assembly Source: UniProtKB
  • extracellular polysaccharide biosynthetic process Source: UniProtKB
  • glycosaminoglycan biosynthetic process Source: ProtInc
  • hyaluronan biosynthetic process Source: GO_Central
  • negative regulation of fibroblast migration Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Glycosyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS02753-MONOMER.
BRENDAi2.4.1.212. 2681.
ReactomeiR-HSA-2142850. Hyaluronan biosynthesis and export.
UniPathwayiUPA00341.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.
TCDBi4.D.1.1.10. the putative vectorial glycosyl polymerization (vgp) family.

Names & Taxonomyi

Protein namesi
Recommended name:
Hyaluronan synthase 1 (EC:2.4.1.212)
Alternative name(s):
Hyaluronate synthase 1
Hyaluronic acid synthase 1
Short name:
HA synthase 1
Short name:
HuHAS1
Gene namesi
Name:HAS1
Synonyms:HAS
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:4818. HAS1.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 25CytoplasmicSequence analysisAdd BLAST25
Transmembranei26 – 46Helical; Name=1Sequence analysisAdd BLAST21
Topological domaini47 – 52ExtracellularSequence analysis6
Transmembranei53 – 73Helical; Name=2Sequence analysisAdd BLAST21
Topological domaini74 – 399CytoplasmicSequence analysisAdd BLAST326
Transmembranei400 – 420Helical; Name=3Sequence analysisAdd BLAST21
Topological domaini421 – 430ExtracellularSequence analysis10
Transmembranei431 – 451Helical; Name=4Sequence analysisAdd BLAST21
Topological domaini452 – 457CytoplasmicSequence analysis6
Transmembranei458 – 478Helical; Name=5Sequence analysisAdd BLAST21
Topological domaini479 – 497ExtracellularSequence analysisAdd BLAST19
Transmembranei498 – 518Helical; Name=6Sequence analysisAdd BLAST21
Topological domaini519 – 540CytoplasmicSequence analysisAdd BLAST22
Transmembranei541 – 561Helical; Name=7Sequence analysisAdd BLAST21
Topological domaini562 – 578ExtracellularSequence analysisAdd BLAST17

GO - Cellular componenti

  • cytoplasm Source: Ensembl
  • integral component of plasma membrane Source: ProtInc
  • plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

DisGeNETi3036.
OpenTargetsiENSG00000105509.
PharmGKBiPA29194.

Polymorphism and mutation databases

BioMutaiHAS1.
DMDMi209572627.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001971691 – 578Hyaluronan synthase 1Add BLAST578

Proteomic databases

PaxDbiQ92839.
PeptideAtlasiQ92839.
PRIDEiQ92839.

PTM databases

iPTMnetiQ92839.
PhosphoSitePlusiQ92839.

Expressioni

Tissue specificityi

Widely expressed. Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine.1 Publication

Gene expression databases

BgeeiENSG00000105509.
CleanExiHS_HAS1.
ExpressionAtlasiQ92839. baseline and differential.
GenevisibleiQ92839. HS.

Organism-specific databases

HPAiHPA067602.

Interactioni

Protein-protein interaction databases

BioGridi109286. 5 interactors.
STRINGi9606.ENSP00000222115.

Structurei

3D structure databases

ProteinModelPortaliQ92839.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the NodC/HAS family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG2571. Eukaryota.
COG1215. LUCA.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
InParanoidiQ92839.
KOiK00752.
PhylomeDBiQ92839.
TreeFamiTF332506.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR026107. HAS/NodC.
IPR028385. HAS1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF4. PTHR22913:SF4. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.

Sequencei

Sequence statusi: Complete.

Q92839-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRQQDAPKPT PAACRCSGLA RRVLTIAFAL LILGLMTWAY AAGVPLASDR
60 70 80 90 100
YGLLAFGLYG AFLSAHLVAQ SLFAYLEHRR VAAAARGPLD AATARSVALT
110 120 130 140 150
ISAYQEDPAY LRQCLASARA LLYPRARLRV LMVVDGNRAE DLYMVDMFRE
160 170 180 190 200
VFADEDPATY VWDGNYHQPW EPAAAGAVGA GAYREVEAED PGRLAVEALV
210 220 230 240 250
RTRRCVCVAQ RWGGKREVMY TAFKALGDSV DYVQVCDSDT RLDPMALLEL
260 270 280 290 300
VRVLDEDPRV GAVGGDVRIL NPLDSWVSFL SSLRYWVAFN VERACQSYFH
310 320 330 340 350
CVSCISGPLG LYRNNLLQQF LEAWYNQKFL GTHCTFGDDR HLTNRMLSMG
360 370 380 390 400
YATKYTSRSR CYSETPSSFL RWLSQQTRWS KSYFREWLYN ALWWHRHHAW
410 420 430 440 450
MTYEAVVSGL FPFFVAATVL RLFYAGRPWA LLWVLLCVQG VALAKAAFAA
460 470 480 490 500
WLRGCLRMVL LSLYAPLYMC GLLPAKFLAL VTMNQSGWGT SGRRKLAANY
510 520 530 540 550
VPLLPLALWA LLLLGGLVRS VAHEARADWS GPSRAAEAYH LAAGAGAYVG
560 570
YWVAMLTLYW VGVRRLCRRR TGGYRVQV
Length:578
Mass (Da):64,832
Last modified:October 14, 2008 - v2
Checksum:i2FE3A44B0D5380FF
GO

Sequence cautioni

The sequence BAA12351 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti1 – 2MR → RS in BAA12351 (PubMed:8651928).Curated2
Sequence conflicti34G → A in BAA12351 (PubMed:8651928).Curated1
Sequence conflicti128L → V in BAA12351 (PubMed:8651928).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_04702514C → R.2 PublicationsCorresponds to variant rs7248778dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84424 mRNA. Translation: BAA12351.1. Different initiation.
U59269 mRNA. Translation: AAC50706.1.
AC018755 Genomic DNA. Translation: AAF87845.1.
CH471135 Genomic DNA. Translation: EAW72038.1.
CCDSiCCDS12838.1.
PIRiJC4812.
RefSeqiNP_001514.2. NM_001523.3.
UniGeneiHs.57697.

Genome annotation databases

EnsembliENST00000222115; ENSP00000222115; ENSG00000105509.
GeneIDi3036.
KEGGihsa:3036.
UCSCiuc002pxo.1. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
D84424 mRNA. Translation: BAA12351.1. Different initiation.
U59269 mRNA. Translation: AAC50706.1.
AC018755 Genomic DNA. Translation: AAF87845.1.
CH471135 Genomic DNA. Translation: EAW72038.1.
CCDSiCCDS12838.1.
PIRiJC4812.
RefSeqiNP_001514.2. NM_001523.3.
UniGeneiHs.57697.

3D structure databases

ProteinModelPortaliQ92839.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109286. 5 interactors.
STRINGi9606.ENSP00000222115.

Protein family/group databases

CAZyiGT2. Glycosyltransferase Family 2.
TCDBi4.D.1.1.10. the putative vectorial glycosyl polymerization (vgp) family.

PTM databases

iPTMnetiQ92839.
PhosphoSitePlusiQ92839.

Polymorphism and mutation databases

BioMutaiHAS1.
DMDMi209572627.

Proteomic databases

PaxDbiQ92839.
PeptideAtlasiQ92839.
PRIDEiQ92839.

Protocols and materials databases

DNASUi3036.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000222115; ENSP00000222115; ENSG00000105509.
GeneIDi3036.
KEGGihsa:3036.
UCSCiuc002pxo.1. human.

Organism-specific databases

CTDi3036.
DisGeNETi3036.
GeneCardsiHAS1.
HGNCiHGNC:4818. HAS1.
HPAiHPA067602.
MIMi601463. gene.
neXtProtiNX_Q92839.
OpenTargetsiENSG00000105509.
PharmGKBiPA29194.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2571. Eukaryota.
COG1215. LUCA.
GeneTreeiENSGT00390000010337.
HOGENOMiHOG000112847.
HOVERGENiHBG000189.
InParanoidiQ92839.
KOiK00752.
PhylomeDBiQ92839.
TreeFamiTF332506.

Enzyme and pathway databases

UniPathwayiUPA00341.
BioCyciZFISH:HS02753-MONOMER.
BRENDAi2.4.1.212. 2681.
ReactomeiR-HSA-2142850. Hyaluronan biosynthesis and export.

Miscellaneous databases

GeneWikiiHAS1.
GenomeRNAii3036.
PROiQ92839.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000105509.
CleanExiHS_HAS1.
ExpressionAtlasiQ92839. baseline and differential.
GenevisibleiQ92839. HS.

Family and domain databases

Gene3Di3.90.550.10. 2 hits.
InterProiIPR026107. HAS/NodC.
IPR028385. HAS1.
IPR029044. Nucleotide-diphossugar_trans.
[Graphical view]
PANTHERiPTHR22913. PTHR22913. 1 hit.
PTHR22913:SF4. PTHR22913:SF4. 1 hit.
SUPFAMiSSF53448. SSF53448. 2 hits.
ProtoNetiSearch...

Entry informationi

Entry nameiHYAS1_HUMAN
AccessioniPrimary (citable) accession number: Q92839
Secondary accession number(s): Q14470, Q9NS49
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: October 14, 2008
Last modified: November 2, 2016
This is version 145 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  6. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.