Reviewed,
UniProtKB/Swiss-Prot Q92839 (HAS1_HUMAN)
Last modified
July 7, 2009.
Version 77.
History...
Clusters with 100%,
90%,
50% identity |
Documents (6) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Hyaluronan synthase 1 EC=2.4.1.212 Alternative name(s): Hyaluronate synthase 1 Hyaluronic acid synthase 1 Short name=HA synthase 1 Short name=HuHAS1 | ||||
| Gene names |
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| Organism | Homo sapiens (Human) [Complete proteome] | ||||
| Taxonomic identifier | 9606 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo |
Protein attributes
| Sequence length | 578 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is not processed. |
| Protein existence | Evidence at protein level. |
General annotation (Comments)
| Function | Plays a role in hyaluronan/hyaluronic acid (HA) synthesis. Also able to catalyze the synthesis of chito-oligosaccharide depending on the substrate. |
| Catalytic activity | UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan). UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan). |
| Cofactor | Magnesium. |
| Pathway | |
| Subcellular location | Membrane; Multi-pass membrane protein Probable. |
| Tissue specificity | Highly expressed in ovary followed by spleen, thymus, prostate, testes and large intestine. Weakly expressed in small intestine. |
| Sequence similarities | Belongs to the nodC/HAS family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Membrane |
| Coding sequence diversity | Polymorphism |
| Domain | Transmembrane |
| Molecular function | Glycosyltransferase Transferase |
| Technical term | Complete proteome |
| Gene Ontology (GO) | |
| Biological process | cell adhesion Ref.2 Traceable author statement. Source: ProtInc glycosaminoglycan biosynthetic process Ref.2Traceable author statement. Source: ProtInc |
| Cellular component | integral to plasma membrane Traceable author statement. Source: ProtInc |
| Molecular function | hyaluronan synthase activity Inferred from electronic annotation. Source: EC protein bindingInferred from physical interaction. Source: IntAct |
| Complete GO annotation... | |
Binary interactions
With | Entry | #Exp. | IntAct | Notes |
|---|---|---|---|---|
| EIF6 | P56537 | 1 | EBI-1052423,EBI-372243 | |
| VHL | P40337 | 1 | EBI-1052423,EBI-301246 |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Chain | 1 – 578 | 578 | Hyaluronan synthase 1 | PRO_0000197169 | |||||
Regions | |||||||||
| Topological domain | 1 – 25 | 25 | Cytoplasmic Potential | ||||||
| Transmembrane | 26 – 46 | 21 | 1 Potential | ||||||
| Topological domain | 47 – 52 | 6 | Extracellular Potential | ||||||
| Transmembrane | 53 – 73 | 21 | 2 Potential | ||||||
| Topological domain | 74 – 399 | 326 | Cytoplasmic Potential | ||||||
| Transmembrane | 400 – 420 | 21 | 3 Potential | ||||||
| Topological domain | 421 – 430 | 10 | Extracellular Potential | ||||||
| Transmembrane | 431 – 451 | 21 | 4 Potential | ||||||
| Topological domain | 452 – 457 | 6 | Cytoplasmic Potential | ||||||
| Transmembrane | 458 – 478 | 21 | 5 Potential | ||||||
| Topological domain | 479 – 497 | 19 | Extracellular Potential | ||||||
| Transmembrane | 498 – 518 | 21 | 6 Potential | ||||||
| Topological domain | 519 – 540 | 22 | Cytoplasmic Potential | ||||||
| Transmembrane | 541 – 561 | 21 | 7 Potential | ||||||
| Topological domain | 562 – 578 | 17 | Extracellular Potential | ||||||
Natural variations | |||||||||
| Natural variant | 14 | 1 | C → R: dbSNP rs7248778. Ref.1 Ref.2 | VAR_047025 | |||||
Experimental info | |||||||||
| Sequence conflict | 1 – 2 | 2 | MR → RS in BAA12351. Ref.1 | ||||||
| Sequence conflict | 34 | 1 | G → A in BAA12351. Ref.1 | ||||||
| Sequence conflict | 128 | 1 | L → V in BAA12351. Ref.1 | ||||||
Sequences
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References
Cross-references
Sequence databases | |
|---|---|
| D84424 mRNA. Translation: BAA12351.1. Different initiation. U59269 mRNA. Translation: AAC50706.1. AC018755 Genomic DNA. Translation: AAF87845.1. CH471135 Genomic DNA. Translation: EAW72038.1. | |
| IPI | IPI00023768. |
| PIR | JC4812. |
| RefSeq | NP_001514.2. |
| UniGene | Hs.57697 |
3D structure databases | |
| ModBase | Search... |
Protein-protein interaction databases | |
| IntAct | Q92839. 2 interactions. |
Protein family/group databases | |
| CAZy | GT2. Glycosyltransferase Family 2. |
PTM databases | |
| PhosphoSite | Q92839. |
Proteomic databases | |
| PRIDE | Q92839. |
Genome annotation databases | |
| Ensembl | ENSG00000105509. Homo sapiens. [Contig view] |
| GeneID | 3036. |
| KEGG | hsa:3036. |
Organism-specific databases | |
| GeneCards | GC19M056908. |
| H-InvDB | HIX0027518. |
| HGNC | HGNC:4818. HAS1. |
| MIM | 601463. gene. |
| PharmGKB | PA29194. |
| GenAtlas | Search... |
Phylogenomic databases | |
| HOGENOM | Q92839. |
| HOVERGEN | Q92839. |
| OMA | Q92839. QSGWGTS. |
Enzyme and pathway databases | |
| BRENDA | 2.4.1.212. 247. |
Gene expression databases | |
| ArrayExpress | Q92839. |
| Bgee | Q92839. |
| CleanEx | HS_HAS1. |
| GermOnline | ENSG00000105509. Homo sapiens. |
Family and domain databases | |
| InterPro | IPR001173. Glyco_trans_2. [Graphical view] |
| Pfam | PF00535. Glycos_transf_2. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 12018. |
| SOURCE | Search... |
Entry information
| Entry name | HAS1_HUMAN | ||||||||
| Accession | Primary (citable) accession number: Q92839 Secondary accession number(s): Q14470, Q9NS49 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| Human chromosome 19 Human chromosome 19: entries, gene names and cross-references to MIM |
| Human entries with polymorphisms or disease mutations List of human entries with polymorphisms or disease mutations |
| Human polymorphisms and disease mutations Index of human polymorphisms and disease mutations |
| MIM cross-references Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot |
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


