Q92837Q5JTI1Q8NE74Q8TDW9FRAT1_HUMANProto-oncogene FRAT1Frequently rearranged in advanced T-cell lymphomas 1FRAT-1FRAT1Homo sapiensHumanEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomoActivation of a novel proto-oncogene, Frat1, contributes to progression of mouse T-cell lymphomas.NUCLEOTIDE SEQUENCE [MRNA]SEQUENCE REVISION TO 170Molecular cloning and expression of proto-oncogene FRAT1 in human cancer.NUCLEOTIDE SEQUENCE [MRNA]The DNA sequence and comparative analysis of human chromosome 10.NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]Casein kinase I epsilon enhances the binding of Dvl-1 to Frat-1 and is essential for Wnt-3a-induced accumulation of beta-catenin.INTERACTION WITH DVL1ROLE IN WNT SIGNALINGLarge-scale proteomics analysis of the human kinome.PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-88IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS]The structure of phosphorylated GSK-3beta complexed with a peptide, FRATtide, that inhibits beta-catenin phosphorylation.X-RAY CRYSTALLOGRAPHY (2.6 ANGSTROMS) OF 198-223 IN COMPLEX WITH GSK-3Positively regulates the Wnt signaling pathway by stabilizing beta-catenin through the association with GSK-3. May play a role in tumor progression and collaborate with PIM1 and MYC in lymphomagenesis.Binds DVL1. Binds GSK-3 and prevent GSK-3-dependent phosphorylation.Q92837P49840false3Q92837P49841false5CytoplasmPhosphorylated.Belongs to the GSK-3-binding protein family.3D-structureCytoplasmPhosphoproteinProto-oncogeneReference proteomeWnt signaling pathwayHDSPMPCRREEEEEAGEEAEGEEEEEDSFLLLQQSVALGSSGEVDRLVAQIGETLQLDAAQHSPASPCGPPGAPLRAPGPLAAAVPADKARSPAVPLLLPPALAETVGPAPPGVLRCALGDRGRVRGRAAPYCVAELATGPSALSPLPPQADLDGPPGAGKQGIPQPLSGPCRRGWLRGAAASRRLQQRRGSQPETRTGDDDPHRLLQQLVLSGNLIKEAVRRLHSRRLQLRAKLPQRPLLGPLSAPVHEPPSPRSPRAACSDPGASGRAQLRTGDGVLVPGS
Copyrighted by the UniProt Consortium, see https://www.uniprot.org/terms Distributed under the Creative Commons Attribution (CC BY 4.0) License