Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 1

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functionⁱ

<p>This subsection of the ‘Function’ section describes the catalytic activity of an enzyme, i.e. the chemical reaction it catalyzes. This information usually correlates with the presence of an EC (Enzyme Commission) number in the ‘Names and taxonomy’ section.<p><a href='/help/catalytic_activity' target='_top'>More...</a></p>Catalytic activityⁱ

<p>This subsection of the ‘Function’ section describes an enzyme regulatory mechanism and reports the components which regulate (by activation or inhibition) the reaction.<p><a href='/help/enzyme_regulation' target='_top'>More...</a></p>Enzyme regulationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• inositol-1,3,4,5-tetrakisphosphate 5-phosphatase activity Source: Reactome
• inositol-polyphosphate 5-phosphatase activity Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 8769125
• phosphatidylinositol-3,4,5-trisphosphate 3-phosphatase activity Source: Reactome
• phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase activity Source: Reactome
• PTB domain binding Source: Ensembl
• SH3 domain binding Source: UniProtKB-KW

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processⁱ

• apoptotic process Source: UniProtKB-KW
• determination of adult lifespan Source: Ensembl
• immunoglobulin mediated immune response Source: Ensembl
• inositol phosphate metabolic process Source: Reactome
• intracellular signal transduction Source: Ensembl
• leukocyte migration Source: Reactome
• negative regulation of B cell proliferation Source: Ensembl
• negative regulation of bone resorption Source: Ensembl
• negative regulation of immune response Source: Ensembl
• negative regulation of interleukin-6 biosynthetic process Source: Ensembl
• negative regulation of monocyte differentiation Source: Ensembl
• negative regulation of neutrophil differentiation Source: Ensembl
• negative regulation of osteoclast differentiation Source: Ensembl
• negative regulation of signal transduction Source: Ensembl
• phosphate-containing compound metabolic process Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 8769125
• phosphatidylinositol biosynthetic process Source: Reactome
• phosphatidylinositol dephosphorylation Source: InterPro
• positive regulation of apoptotic process Source: Ensembl
• positive regulation of B cell differentiation Source: Ensembl
• positive regulation of erythrocyte differentiation Source: Ensembl
• signal transduction Source: ProtInc <p>Traceable Author Statement</p> <p>Used for information from review articles where the original experiments are traceable through that article and also for information from text books or dictionaries.</p> <p>More information in the <a href="http://geneontology.org/page/guide-go-evidence-codes#tas">GO evidence code guide</a></p> Traceable author statementⁱ
  • 8769125
• T cell receptor signaling pathway Source: Reactome

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywordsⁱ

Enzyme and pathway databases

Chemistry databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyⁱ

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Cellular componentⁱ

• cytoskeleton Source: UniProtKB-SubCell
• cytosol Source: HPA
• membrane raft Source: UniProtKB-SubCell
• plasma membrane Source: UniProtKB-SubCell

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Cellular componentⁱ

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechⁱ

Organism-specific databases

Chemistry databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingⁱ

Molecule processing

Amino acid modifications

<p>This subsection of the <a href="http://www.uniprot.org/help/ptm_processing_section"><span class="caps">PTM</span>/processing</a> section describes post-translational modifications (PTMs). This subsection <strong>complements</strong> the information provided at the sequence level or describes modifications for which <strong>position-specific data is not yet available</strong>.<p><a href='/help/post-translational_modification' target='_top'>More...</a></p>Post-translational modificationⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - PTMⁱ

Proteomic databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressionⁱ

<p>This subsection of the ‘Expression’ section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms. By default, the information is derived from experiments at the mRNA level, unless specified ‘at protein level’.<br></br>Examples: <a href="http://www.uniprot.org/uniprot/P92958#expression"><span class="caps">P92958</span></a>, <a href="http://www.uniprot.org/uniprot/Q8TDN4#expression"><span class="caps">Q8TDN4</span></a>, <a href="http://www.uniprot.org/uniprot/O14734#expression"><span class="caps">O14734</span></a><p><a href='/help/tissue_specificity' target='_top'>More...</a></p>Tissue specificityⁱ

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactionⁱ

<p>This subsection of the <a href="http://www.uniprot.org/help/interaction_section">‘Interaction’</a> section provides information about the protein quaternary structure and interaction(s) with other proteins or protein complexes (with the exception of physiological receptor-ligand interactions which are annotated in the <a href="http://www.uniprot.org/help/function_section">‘Function’</a> section).<p><a href='/help/subunit_structure' target='_top'>More...</a></p>Subunit structureⁱ

<p>This subsection of the ‘Interaction’ section provides information about binary protein-protein interactions. The data presented in this section are a quality-filtered subset of binary interactions automatically derived from the <a href="http://www.ebi.ac.uk/intact/">IntAct database</a>. It is updated on a monthly basis. Each binary interaction is displayed on a separate line.<p><a href='/help/binary_interactions' target='_top'>More...</a></p>Binary interactionsⁱ

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functionⁱ

• PTB domain binding Source: Ensembl
• SH3 domain binding Source: UniProtKB-KW

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structureⁱ

Secondary structure

3D structure databases

Miscellaneous databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsⁱ

Domains and Repeats

Region

Motif

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides general information on the biological role of a domain. The term ‘domain’ is intended here in its wide acceptation, it may be a structural domain, a transmembrane region or a functional domain. Several domains are described in this subsection.<p><a href='/help/domain_cc' target='_top'>More...</a></p>Domainⁱ

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Domainⁱ

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (3)ⁱ

<p>This subsection of the ‘Sequence’ section indicates if the <a href="http://www.uniprot.org/help/canonical_and_isoforms">canonical sequence</a> displayed by default in the entry is complete or not.<p><a href='/help/sequence_status' target='_top'>More...</a></p>Sequence statusⁱ: Complete.

This entry describes 3 <p>This subsection of the ‘Sequence’ section lists the alternative protein sequences (isoforms) that can be generated from the same gene by a single or by the combination of up to four biological events (alternative promoter usage, alternative splicing, alternative initiation and ribosomal frameshifting). Additionally, this section gives relevant information on each alternative protein isoform.<p><a href='/help/alternative_products' target='_top'>More...</a></p> isoformsⁱ produced by alternative splicing. AlignAdd to basketAdded to basket

        10         20         30         40         50
MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV 
        60         70         80         90        100
YTYRILPNED DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP 
       110        120        130        140        150
VPLEEEDTGD DPEEDTVESV VSPPELPPRN IPLTASSCEA KEVPFSNENP 
       160        170        180        190        200
RATETSRPSL SETLFQRLQS MDTSGLPEEH LKAIQDYLST QLAQDSEFVK 
       210        220        230        240        250
TGSSSLPHLK KLTTLLCKEL YGEVIRTLPS LESLQRLFDQ QLSPGLRPRP 
       260        270        280        290        300
QVPGEANPIN MVSKLSQLTS LLSSIEDKVK ALLHEGPESP HRPSLIPPVT 
       310        320        330        340        350
FEVKAESLGI PQKMQLKVDV ESGKLIIKKS KDGSEDKFYS HKKILQLIKS 
       360        370        380        390        400
QKFLNKLVIL VETEKEKILR KEYVFADSKK REGFCQLLQQ MKNKHSEQPE 
       410        420        430        440        450
PDMITIFIGT WNMGNAPPPK KITSWFLSKG QGKTRDDSAD YIPHDIYVIG 
       460        470        480        490        500
TQEDPLSEKE WLEILKHSLQ EITSVTFKTV AIHTLWNIRI VVLAKPEHEN 
       510        520        530        540        550
RISHICTDNV KTGIANTLGN KGAVGVSFMF NGTSLGFVNS HLTSGSEKKL 
       560        570        580        590        600
RRNQNYMNIL RFLALGDKKL SPFNITHRFT HLFWFGDLNY RVDLPTWEAE 
       610        620        630        640        650
TIIQKIKQQQ YADLLSHDQL LTERREQKVF LHFEEEEITF APTYRFERLT 
       660        670        680        690        700
RDKYAYTKQK ATGMKYNLPS WCDRVLWKSY PLVHVVCQSY GSTSDIMTSD 
       710        720        730        740        750
HSPVFATFEA GVTSQFVSKN GPGTVDSQGQ IEFLRCYATL KTKSQTKFYL 
       760        770        780        790        800
EFHSSCLESF VKSQEGENEE GSEGELVVKF GETLPKLKPI ISDPEYLLDQ 
       810        820        830        840        850
HILISIKSSD SDESYGEGCI ALRLEATETQ LPIYTPLTHH GELTGHFQGE 
       860        870        880        890        900
IKLQTSQGKT REKLYDFVKT ERDESSGPKT LKSLTSHDPM KQWEVTSRAP 
       910        920        930        940        950
PCSGSSITEI INPNYMGVGP FGPPMPLHVK QTLSPDQQPT AWSYDQPPKD 
       960        970        980        990       1000
SPLGPCRGES PPTPPGQPPI SPKKFLPSTA NRGLPPRTQE SRPSDLGKNA 
      1010       1020       1030       1040       1050
GDTLPQEDLP LTKPEMFENP LYGSLSSFPK PAPRKDQESP KMPRKEPPPC 
      1060       1070       1080       1090       1100
PEPGILSPSI VLTKAQEADR GEGPGKQVPA PRLRSFTCSS SAEGRAAGGD 
      1110       1120       1130       1140       1150
KSQGKPKTPV SSQAPVPAKR PIKPSRSEIN QQTPPTPTPR PPLPVKSPAV 
      1160       1170       1180 
LHLQHSKGRD YRDNTELPHH GKHRPEEGPP GPLGRTAMQ            

        10         20         30         40         50
MVPCWNHGNI TRSKAEELLS RTGKDGSFLV RASESISRAY ALCVLYRNCV 
        60         70         80         90        100
YTYRILPNED DKFTVQASEG VSMRFFTKLD QLIEFYKKEN MGLVTHLQYP 
       110        120        130        140        150
VPLEEEDTGD DPEEDTESVV SPPELPPRNI PLTASSCEAK EVPFSNENPR 
       160        170        180        190        200
ATETSRPSLS ETLFQRLQSM DTSGLPEEHL KAIQDYLSTQ LAQDSEFVKT 
       210        220        230        240        250
GSSSLPHLKK LTTLLCKELY GEVIRTLPSL ESLQRLFDQQ LSPGLRPRPQ 
       260        270        280        290        300
VPGEANPINM VSKLSQLTSL LSSIEDKVKA LLHEGPESPH RPSLIPPVTF 
       310        320        330        340        350
EVKAESLGIP QKMQLKVDVE SGKLIIKKSK DGSEDKFYSH KKILQLIKSQ 
       360        370        380        390        400
KFLNKLVILV ETEKEKILRK EYVFADSKKR EGFCQLLQQM KNKHSEQPEP 
       410        420        430        440        450
DMITIFIGTW NMGNAPPPKK ITSWFLSKGQ GKTRDDSADY IPHDIYVIGT 
       460        470        480        490        500
QEDPLSEKEW LEILKHSLQE ITSVTFKTVA IHTLWNIRIV VLAKPEHENR 
       510        520        530        540        550
ISHICTDNVK TGIANTLGNK GAVGVSFMFN GTSLGFVNSH LTSGSEKKLR 
       560        570        580        590        600
RNQNYMNILR FLALGDKKLS PFNITHRFTH LFWFGDLNYR VDLPTWEAET 
       610        620        630        640        650
IIQKIKQQQY ADLLSHDQLL TERREQKVFL HFEEEEITFA PTYRFERLTR 
       660        670        680        690        700
DKYAYTKQKA TGMKYNLPSW CDRVLWKSYP LVHVVCQSYG STSDIMTSDH 
       710        720        730        740        750
SPVFATFEAG VTSQFVSKNG PGTVDSQGQI EFLRCYATLK TKSQTKFYLE 
       760        770        780        790        800
FHSSCLESFV KSQEGENEEG SEGELVVKFG ETLPKLKPII SDPEYLLDQH 
       810        820        830        840        850
ILISIKSSDS DESYGEGCIA LRLEATETQL PIYTPLTHHG ELTGHFQGEI 
       860        870        880        890        900
KLQTSQGKTR EKLYDFVKTE RDESSGPKTL KSLTSHDPMK QWEVTSRAPP 
       910        920        930        940        950
CSGSSITEII NPNYMGVGPF GPPMPLHVKQ TLSPDQQPTA WSYDQPPKDS 
       960        970        980        990       1000
PLGPCRGESP PTPPGQPPIS PKKFLPSTAN RGLPPRTQES RPSDLGKNAG 
      1010       1020       1030       1040       1050
DTLPQEDLPL TKPEMFENPL YGSLSSFPKP APRKDQESPK MPRKEPPPCP 
      1060       1070       1080       1090       1100
EPGILSPSIV LTKAQEADRG EGPGKQVPAP RLRSFTCSSS AEGRAAGGDK 
      1110       1120       1130       1140       1150
SQGKPKTPVS SQAPVPAKRP IKPSRSEINQ QTPPTPTPRP PLPVKSPAVL 
      1160       1170       1180 
HLQHSKGRDY RDNTELPHHG KHRPEEGPPG PLGRTAMQ            

        10         20         30         40         50
MFTLSPAPRE VIRTLPSLES LQRLFDQQLS PGLRPRPQVP GEANPINMVS 
        60         70         80         90        100
KLSQLTSLLS SIEDKVKALL HEGPESPHRP SLIPPVTFEV KAESLGIPQK 
       110        120        130        140        150
MQLKVDVESG KLIIKKSKDG SEDKFYSHKK ILQLIKSQKF LNKLVILVET 
       160        170        180        190        200
EKEKILRKEY VFADSKKREG FCQLLQQMKN KHSEQPEPDM ITIFIGTWNM 
       210        220        230        240        250
GNAPPPKKIT SWFLSKGQGK TRDDSADYIP HDIYVIGTQE DPLSEKEWLE 
       260        270        280        290        300
ILKHSLQEIT SVTFKTVAIH TLWNIRIVVL AKPEHENRIS HICTDNVKTG 
       310        320        330        340        350
IANTLGNKGA VGVSFMFNGT SLGFVNSHLT SGSEKKLRRN QNYMNILRFL 
       360        370        380        390        400
ALGDKKLSPF NITHRFTHLF WFGDLNYRVD LPTWEAETII QKIKQQQYAD 
       410        420        430        440        450
LLSHDQLLTE RREQKVFLHF EEEEITFAPT YRFERLTRDK YAYTKQKATG 
       460        470        480        490        500
MKYNLPSWCD RVLWKSYPLV HVVCQSYGST SDIMTSDHSP VFATFEAGVT 
       510        520        530        540        550
SQFVSKNGPG TVDSQGQIEF LRCYATLKTK SQTKFYLEFH SSCLESFVKS 
       560        570        580        590        600
QEGENEEGSE GELVVKFGET LPKLKPIISD PEYLLDQHIL ISIKSSDSDE 
       610        620        630        640        650
SYGEGCIALR LEATETQLPI YTPLTHHGEL TGHFQGEIKL QTSQGKTREK 
       660        670        680        690        700
LYDFVKTERD ESSGPKTLKS LTSHDPMKQW EVTSRAPPCS GSSITEIINP 
       710        720        730        740        750
NYMGVGPFGP PMPLHVKQTL SPDQQPTAWS YDQPPKDSPL GPCRGESPPT 
       760        770        780        790        800
PPGQPPISPK KFLPSTANRG LPPRTQESRP SDLGKNAGDT LPQEDLPLTK 
       810        820        830        840        850
PEMFENPLYG SLSSFPKPAP RKDQESPKMP RKEPPPCPEP GILSPSIVLT 
       860        870        880        890        900
KAQEADRGEG PGKQVPAPRL RSFTCSSSAE GRAAGGDKSQ GKPKTPVSSQ 
       910        920        930        940        950
APVPAKRPIK PSRSEINQQT PPTPTPRPPL PVKSPAVLHL QHSKGRDYRD 
       960        970 
NTELPHHGKH RPEEGPPGPL GRTAMQ                       

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautionⁱ

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Coding sequence diversityⁱ

<p>This section provides links to the UniProt Reference Clusters (<a href="http://www.uniprot.org/help/uniref">UniRef</a>). UniRef consists of clusters for UniProtKB sequences (including isoforms) and selected UniParc sequences, in order to obtain complete coverage of the sequence space at resolutions of 100%, 90% and 50% identity.<p><a href='/help/similar_proteins_section' target='_top'>More...</a></p>Similar proteinsⁱ

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesⁱ

Sequence databases

3D structure databases

Protein-protein interaction databases

Chemistry databases

PTM databases

Polymorphism and mutation databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationⁱ

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousⁱ

<p>UniProtKB Keywords constitute a <a href="http://www.uniprot.org/keywords">controlled vocabulary</a> with a hierarchical structure. Keywords summarise the content of a UniProtKB entry and facilitate the search for proteins of interest.<p><a href='/help/keywords' target='_top'>More...</a></p>Keywords - Technical termⁱ

Documents

1. Human chromosome 2
   Human chromosome 2: entries, gene names and cross-references to MIM
2. Human entries with polymorphisms or disease mutations
   List of human entries with polymorphisms or disease mutations
3. Human polymorphisms and disease mutations
   Index of human polymorphisms and disease mutations
4. MIM cross-references
   Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
5. PDB cross-references
   Index of Protein Data Bank (PDB) cross-references
6. SIMILARITY comments
   Index of protein domains and families