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Protein

Protein Jumonji

Gene

JARID2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.1 Publication

Caution

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionChromatin regulator, Developmental protein, Repressor
Biological processDifferentiation, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-212300 PRC2 methylates histones and DNA
SIGNORiQ92833

Names & Taxonomyi

Protein namesi
Recommended name:
Protein Jumonji
Alternative name(s):
Jumonji/ARID domain-containing protein 2
Gene namesi
Name:JARID2
Synonyms:JMJ
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 6

Organism-specific databases

EuPathDBiHostDB:ENSG00000008083.13
HGNCiHGNC:6196 JARID2
MIMi601594 gene
neXtProtiNX_Q92833

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi3720
OpenTargetsiENSG00000008083
PharmGKBiPA29995

Polymorphism and mutation databases

BioMutaiJARID2
DMDMi61252601

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002005911 – 1246Protein JumonjiAdd BLAST1246

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei78PhosphoserineCombined sources1
Modified residuei378N6-acetyllysineCombined sources1
Modified residuei455PhosphoserineCombined sources1

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

EPDiQ92833
MaxQBiQ92833
PaxDbiQ92833
PeptideAtlasiQ92833
PRIDEiQ92833

PTM databases

iPTMnetiQ92833
PhosphoSitePlusiQ92833

Expressioni

Tissue specificityi

During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.

Gene expression databases

BgeeiENSG00000008083
CleanExiHS_JARID2
GenevisibleiQ92833 HS

Organism-specific databases

HPAiCAB069890
HPA063889

Interactioni

Subunit structurei

Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 (By similarity). Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12. Interacts with ESRRB (By similarity).By similarity

Binary interactionsi

Show more details

GO - Molecular functioni

Protein-protein interaction databases

BioGridi10992322 interactors.
DIPiDIP-45494N
IntActiQ92833 24 interactors.
STRINGi9606.ENSP00000341280

Structurei

Secondary structure

11246
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi144 – 146Combined sources3
Helixi147 – 150Combined sources4
Beta strandi153 – 156Combined sources4
Turni160 – 163Combined sources4

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
5HYNX-ray2.95E/J/P/U110-121[»]
5LS6X-ray3.47Q/R/S/T110-120[»]
6C23electron microscopy3.90B/E106-450[»]
6C24electron microscopy3.50B/E106-450[»]
ProteinModelPortaliQ92833
SMRiQ92833
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini557 – 598JmjNPROSITE-ProRule annotationAdd BLAST42
Domaini621 – 713ARIDPROSITE-ProRule annotationAdd BLAST93
Domaini884 – 1048JmjCPROSITE-ProRule annotationAdd BLAST165

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi104 – 110Nuclear localization signalBy similarity7
Motifi874 – 878GSGFP motif5

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1234 – 1246Poly-SerAdd BLAST13

Domaini

The ARID domain is required to target the PRC2 complex to its target genes.By similarity
The GSGFP motif is required for the interaction with SUZ12.By similarity

Phylogenomic databases

eggNOGiENOG410ISPM Eukaryota
ENOG410YJEB LUCA
GeneTreeiENSGT00530000063118
HOGENOMiHOG000013203
HOVERGENiHBG052160
InParanoidiQ92833
KOiK11478
OMAiARNIMNM
OrthoDBiEOG091G00OP
PhylomeDBiQ92833
TreeFamiTF323264

Family and domain databases

Gene3Di1.10.150.601 hit
InterProiView protein in InterPro
IPR001606 ARID_dom
IPR036431 ARID_dom_sf
IPR003347 JmjC_dom
IPR003349 JmjN
IPR004198 Znf_C5HC2
PfamiView protein in Pfam
PF01388 ARID, 1 hit
PF02373 JmjC, 1 hit
PF02375 JmjN, 1 hit
PF02928 zf-C5HC2, 1 hit
SMARTiView protein in SMART
SM00501 BRIGHT, 1 hit
SM00558 JmjC, 1 hit
SM00545 JmjN, 1 hit
SUPFAMiSSF46774 SSF46774, 1 hit
PROSITEiView protein in PROSITE
PS51011 ARID, 1 hit
PS51184 JMJC, 1 hit
PS51183 JMJN, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92833-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE
60 70 80 90 100
GIAGSLKTVN GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF
110 120 130 140 150
EEGPSRKRPR LQAQRKFAQS QPNSPSTTPV KIVEPLLPPP ATQISDLSKR
160 170 180 190 200
KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ DEEEVEEEDD ETEDVKTATN
210 220 230 240 250
NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK HKSKEATPAK
260 270 280 290 300
EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR
310 320 330 340 350
KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT
360 370 380 390 400
KAKRELVKDT KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST
410 420 430 440 450
GPAVNGLKVS GRLNPKSCTK EVGGRQLREG LQLREGLRNS KRRLEEAHQA
460 470 480 490 500
EKPQSPPKKM KGAAGPAEGP GKKAPAERGL LNGHVKKEVP ERSLERNRPK
510 520 530 540 550
RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG KAEKGGGKAG
560 570 580 590 600
WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK
610 620 630 640 650
LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG
660 670 680 690 700
CELDLACFFR LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA
710 720 730 740 750
YCQYLLSYDS LSPEEHRRLE KEVLMEKEIL EKRKGPLEGH TENDHHKFHP
760 770 780 790 800
LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA QLKTGRRRLF AQEKEVVKEE
810 820 830 840 850
EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE PAPAEIEQEY
860 870 880 890 900
WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG
910 920 930 940 950
SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY
960 970 980 990 1000
CIPAEEENKL EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT
1010 1020 1030 1040 1050
VQQSGQFVVC FPGSFVSKVC CGYSVSETVH FATTQWTSMG FETAKEMKRR
1060 1070 1080 1090 1100
HIAKPFSMEK LLYQIAQAEA KKENGPTLST ISALLDELRD TELRQRRQLF
1110 1120 1130 1140 1150
EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ ICQHLCYLSM
1160 1170 1180 1190 1200
VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV
1210 1220 1230 1240
SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS
Length:1,246
Mass (Da):138,734
Last modified:March 15, 2005 - v2
Checksum:iE4929984259110DB
GO
Isoform 2 (identifier: Q92833-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MSKERPKRNI...GIAGSLKTVN → MAAPRVCQVQFLVAYLEEPGIE
     949-1246: WYCIPAEEEN...SSSKSASSSS → CLSVEPVFPH...AWRGVLGPRL

Note: No experimental confirmation available.
Show »
Length:960
Mass (Da):106,139
Checksum:i985C77D3B34F699B
GO
Isoform 3 (identifier: Q92833-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-172: Missing.

Note: No experimental confirmation available.
Show »
Length:1,074
Mass (Da):119,689
Checksum:iA913DFCF25573C4A
GO

Sequence cautioni

The sequence AAC50822 differs from that shown. Reason: Frameshift at position 1233.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti250K → E in BAH13011 (PubMed:14702039).Curated1
Sequence conflicti599C → S in BAH13011 (PubMed:14702039).Curated1
Sequence conflicti673D → E in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti681A → S in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti688R → K in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti692D → E in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti705L → I in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti754F → L in AAC50822 (PubMed:8894700).Curated1
Sequence conflicti1212S → H in AAC50822 (PubMed:8894700).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0450411 – 172Missing in isoform 3. 1 PublicationAdd BLAST172
Alternative sequenceiVSP_0387561 – 60MSKER…LKTVN → MAAPRVCQVQFLVAYLEEPG IE in isoform 2. 1 PublicationAdd BLAST60
Alternative sequenceiVSP_038757949 – 1246WYCIP…ASSSS → CLSVEPVFPHLSVAVGSIVD LGISFLPCGDTRVMYPVESV AWRGVLGPRL in isoform 2. 1 PublicationAdd BLAST298

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57592 mRNA Translation: AAC50822.1 Frameshift.
AK292861 mRNA Translation: BAF85550.1
AK299349 mRNA Translation: BAH13011.1
AK303610 mRNA Translation: BAH13996.1
AL136162, AL021938 Genomic DNA Translation: CAI15719.1
AL021938, AL136162 Genomic DNA Translation: CAI19873.1
CH471087 Genomic DNA Translation: EAW55357.1
BC046184 mRNA Translation: AAH46184.1
BC046246 mRNA Translation: AAH46246.1
CCDSiCCDS4533.1 [Q92833-1]
CCDS58996.1 [Q92833-3]
RefSeqiNP_001253969.1, NM_001267040.1 [Q92833-3]
NP_004964.2, NM_004973.3 [Q92833-1]
XP_005249146.1, XM_005249089.3 [Q92833-3]
XP_016866323.1, XM_017010834.1 [Q92833-3]
XP_016866324.1, XM_017010835.1 [Q92833-3]
UniGeneiHs.269059

Genome annotation databases

EnsembliENST00000341776; ENSP00000341280; ENSG00000008083 [Q92833-1]
ENST00000397311; ENSP00000380478; ENSG00000008083 [Q92833-3]
GeneIDi3720
KEGGihsa:3720
UCSCiuc003nbj.5 human [Q92833-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiJARD2_HUMAN
AccessioniPrimary (citable) accession number: Q92833
Secondary accession number(s): A8K9Z6
, B7Z5S5, B7Z8L0, Q5U5L5, Q86X63
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: March 15, 2005
Last modified: April 25, 2018
This is version 157 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome