Q92833 (JARD2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein Jumonji

Alternative name(s):
Jumonji/ARID domain-containing protein 2

Gene names

Name:	JARID2
Synonyms:	JMJ

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	1246 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling. Ref.7
Subunit structure	Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 By similarity. Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12.
Subcellular location	Nucleus. Note: Colocalizes with the PRC2 complex on chromatin. Ref.7
Tissue specificity	During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.
Domain	The ARID domain is required to target the PRC2 complex to its target genes By similarity. The GSGFP motif is required for the interaction with SUZ12 By similarity.
Sequence similarities	Contains 1 ARID domain. Contains 1 JmjC domain. Contains 1 JmjN domain.
Sequence caution	The sequence AAC50822.1 differs from that shown. Reason: Frameshift at position 1233.

Ontologies

Keywords
Biological process	Differentiation Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Molecular function	Chromatin regulator Developmental protein Repressor
PTM	Acetylation
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	central nervous system development Traceable author statement. Source: ProtInc chromatin modification Inferred from electronic annotation. Source: UniProtKB-KW negative regulation of histone methylation Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of histone H3-K9 methylation Inferred from sequence or structural similarity. Source: UniProtKB stem cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	chromatin binding Inferred from sequence or structural similarity. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92833-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92833-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-60: MSKERPKRNI...GIAGSLKTVN → MAAPRVCQVQFLVAYLEEPGIE
     949-1246: WYCIPAEEEN...SSSKSASSSS → CLSVEPVFPH...AWRGVLGPRL

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 1246	1246	Protein Jumonji		PRO_0000200591
Regions
	Domain	557 – 598	42	JmjN
	Domain	621 – 713	93	ARID
	Domain	884 – 1048	165	JmjC
	Motif	104 – 110	7	Nuclear localization signal By similarity
	Motif	874 – 878	5	GSGFP motif
	Compositional bias	1234 – 1246	13	Poly-Ser
Amino acid modifications
	Modified residue	378	1	N6-acetyllysine Ref.6
Natural variations
	Alternative sequence	1 – 60	60	MSKER…LKTVN → MAAPRVCQVQFLVAYLEEPG IE in isoform 2.		VSP_038756
	Alternative sequence	949 – 1246	298	WYCIP…ASSSS → CLSVEPVFPHLSVAVGSIVD LGISFLPCGDTRVMYPVESV AWRGVLGPRL in isoform 2.		VSP_038757
Experimental info
	Sequence conflict	250	1	K → E in BAH13011. Ref.2
	Sequence conflict	599	1	C → S in BAH13011. Ref.2
	Sequence conflict	673	1	D → E in AAC50822. Ref.1
	Sequence conflict	681	1	A → S in AAC50822. Ref.1
	Sequence conflict	688	1	R → K in AAC50822. Ref.1
	Sequence conflict	692	1	D → E in AAC50822. Ref.1
	Sequence conflict	705	1	L → I in AAC50822. Ref.1
	Sequence conflict	754	1	F → L in AAC50822. Ref.1
	Sequence conflict	1212	1	S → H in AAC50822. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified March 15, 2005. Version 2. Checksum: E4929984259110DB	FASTA	1,246	138,734
	10 20 30 40 50 60 MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE GIAGSLKTVN 70 80 90 100 110 120 GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF EEGPSRKRPR LQAQRKFAQS 130 140 150 160 170 180 QPNSPSTTPV KIVEPLLPPP ATQISDLSKR KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ 190 200 210 220 230 240 DEEEVEEEDD ETEDVKTATN NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK 250 260 270 280 290 300 HKSKEATPAK EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR 310 320 330 340 350 360 KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT KAKRELVKDT 370 380 390 400 410 420 KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST GPAVNGLKVS GRLNPKSCTK 430 440 450 460 470 480 EVGGRQLREG LQLREGLRNS KRRLEEAHQA EKPQSPPKKM KGAAGPAEGP GKKAPAERGL 490 500 510 520 530 540 LNGHVKKEVP ERSLERNRPK RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG 550 560 570 580 590 600 KAEKGGGKAG WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK 610 620 630 640 650 660 LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG CELDLACFFR 670 680 690 700 710 720 LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA YCQYLLSYDS LSPEEHRRLE 730 740 750 760 770 780 KEVLMEKEIL EKRKGPLEGH TENDHHKFHP LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA 790 800 810 820 830 840 QLKTGRRRLF AQEKEVVKEE EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE 850 860 870 880 890 900 PAPAEIEQEY WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG 910 920 930 940 950 960 SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY CIPAEEENKL 970 980 990 1000 1010 1020 EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT VQQSGQFVVC FPGSFVSKVC 1030 1040 1050 1060 1070 1080 CGYSVSETVH FATTQWTSMG FETAKEMKRR HIAKPFSMEK LLYQIAQAEA KKENGPTLST 1090 1100 1110 1120 1130 1140 ISALLDELRD TELRQRRQLF EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ 1150 1160 1170 1180 1190 1200 ICQHLCYLSM VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV 1210 1220 1230 1240 SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS
	Isoform 2 [UniParc]. Checksum: 985C77D3B34F699B	FASTA	960	106,139
	10 20 30 40 50 60 MAAPRVCQVQ FLVAYLEEPG IEGLLGNDQS KGLGPASEQS ENEKDDASQV SSTSNDVSSS 70 80 90 100 110 120 DFEEGPSRKR PRLQAQRKFA QSQPNSPSTT PVKIVEPLLP PPATQISDLS KRKPKTEDFL 130 140 150 160 170 180 TFLCLRGSPA LPNSMVYFGS SQDEEEVEEE DDETEDVKTA TNNASSSCQS TPRKGKTHKH 190 200 210 220 230 240 VHNGHVFNGS SRSTREKEPV QKHKSKEATP AKEKHSDHRA DSRREQASAN HPAAAPSTGS 250 260 270 280 290 300 SAKGLAATHH HPPLHRSAQD LRKQVSKVNG VTRMSSLGAG VTSAKKMREV RPSPSKTVKY 310 320 330 340 350 360 TATVTKGAVT YTKAKRELVK DTKPNHHKPS SAVNHTISGK TESSNAKTRK QVLSLGGASK 370 380 390 400 410 420 STGPAVNGLK VSGRLNPKSC TKEVGGRQLR EGLQLREGLR NSKRRLEEAH QAEKPQSPPK 430 440 450 460 470 480 KMKGAAGPAE GPGKKAPAER GLLNGHVKKE VPERSLERNR PKRATAGKST PGRQAHGKAD 490 500 510 520 530 540 SASCENRSTS QPESVHKPQD SGKAEKGGGK AGWAAMDEIP VLRPSAKEFH DPLIYIESVR 550 560 570 580 590 600 AQVEKFGMCR VIPPPDWRPE CKLNDEMRFV TQIQHIHKLG RRWGPNVQRL ACIKKHLKSQ 610 620 630 640 650 660 GITMDELPLI GGCELDLACF FRLINEMGGM QQVTDLKKWN KLADMLRIPR TAQDRLAKLQ 670 680 690 700 710 720 EAYCQYLLSY DSLSPEEHRR LEKEVLMEKE ILEKRKGPLE GHTENDHHKF HPLPRFEPKN 730 740 750 760 770 780 GLIHGVAPRN GFRSKLKEVG QAQLKTGRRR LFAQEKEVVK EEEEDKGVLN DFHKCIYKGR 790 800 810 820 830 840 SVSLTTFYRT ARNIMSMCFS KEPAPAEIEQ EYWRLVEEKD CHVAVHCGKV DTNTHGSGFP 850 860 870 880 890 900 VGKSEPFSRH GWNLTVLPNN TGSILRHLGA VPGVTIPWLN IGMVFSTSCW SRDQNHLPYI 910 920 930 940 950 960 DYLHTGADCI CLSVEPVFPH LSVAVGSIVD LGISFLPCGD TRVMYPVESV AWRGVLGPRL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of the human jumonji gene." Berge-Lefranc J.-L., Jay P., Massacrier A., Cau P., Mattei M.-G., Bauer S., Marsollier C., Berta P., Fontes M. Hum. Mol. Genet. 5:1637-1641(1996) [PubMed: 8894700] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2). Tissue: Trachea.
[3]	"The DNA sequence and analysis of human chromosome 6." Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D. , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S. Nature 425:805-811(2003) [PubMed: 14574404] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Mammary gland and Testis.
[6]	"Lysine acetylation targets protein complexes and co-regulates major cellular functions." Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T., Olsen J.V., Mann M. Science 325:834-840(2009) [PubMed: 19608861] [Abstract] Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-378, MASS SPECTROMETRY.
[7]	"JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells." Pasini D., Cloos P.A., Walfridsson J., Olsson L., Bukowski J.P., Johansen J.V., Bak M., Tommerup N., Rappsilber J., Helin K. Nature 464:306-310(2010) [PubMed: 20075857] [Abstract] Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE PRC2 COMPLEX.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U57592 mRNA. Translation: AAC50822.1. Frameshift. AK292861 mRNA. Translation: BAF85550.1. AK299349 mRNA. Translation: BAH13011.1. AL136162, AL021938 Genomic DNA. Translation: CAI15719.1. AL021938, AL136162 Genomic DNA. Translation: CAI19873.1. CH471087 Genomic DNA. Translation: EAW55357.1. BC046184 mRNA. Translation: AAH46184.1. BC046246 mRNA. Translation: AAH46246.1.
IPI	IPI00023756. IPI00955447.
RefSeq	NP_004964.2. NM_004973.2.
UniGene	Hs.269059.
3D structure databases
ProteinModelPortal	Q92833.
SMR	Q92833. Positions 617-732.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-45494N.
IntAct	Q92833. 1 interaction.
STRING	Q92833.
PTM databases
PhosphoSite	Q92833.
Polymorphism databases
DMDM	61252601.
Proteomic databases
PRIDE	Q92833.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000341776; ENSP00000341280; ENSG00000008083.
GeneID	3720.
KEGG	hsa:3720.
UCSC	uc003nbj.1. human.
Organism-specific databases
CTD	3720.
GeneCards	GC06P015246.
H-InvDB	HIX0025036.
HGNC	HGNC:6196. JARID2.
HPA	HPA044909.
MIM	601594. gene.
neXtProt	NX_Q92833.
PharmGKB	PA29995.
GenAtlas	Search...
Phylogenomic databases
eggNOG	prNOG16507.
HOGENOM	HBG444455.
HOVERGEN	HBG052160.
InParanoid	Q92833.
OMA	DPLIYIE.
OrthoDB	EOG4KKZ26.
PhylomeDB	Q92833.
Gene expression databases
ArrayExpress	Q92833.
Bgee	Q92833.
CleanEx	HS_JARID2.
Genevestigator	Q92833.
GermOnline	ENSG00000008083. Homo sapiens.
Family and domain databases
InterPro	IPR001606. ARID/BRIGHT_DNA-bd. IPR013129. TF_JmjC. IPR003347. TF_JmjC_AAH. IPR003349. TF_JmjN. IPR004198. Znf_C5HC2. [Graphical view]
Gene3D	G3DSA:1.10.150.60. ARID. 1 hit.
KO	K11478.
Pfam	PF01388. ARID. 1 hit. PF02373. JmjC. 1 hit. PF02375. JmjN. 1 hit. PF02928. zf-C5HC2. 1 hit. [Graphical view]
SMART	SM00501. BRIGHT. 1 hit. SM00558. JmjC. 1 hit. SM00545. JmjN. 1 hit. [Graphical view]
SUPFAM	SSF46774. ARID. 1 hit.
PROSITE	PS51011. ARID. 1 hit. PS51184. JMJC. 1 hit. PS51183. JMJN. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	14577.
SOURCE	Search...

Entry information

Entry name

JARD2_HUMAN

Accession

Primary (citable) accession number: Q92833
Secondary accession number(s): A8K9Z6 , B7Z5S5, Q5U5L5, Q86X63

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	March 15, 2005
Last modified:	January 25, 2012
This is version 97 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.