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Q92833

- JARD2_HUMAN

UniProt

Q92833 - JARD2_HUMAN

Protein

Protein Jumonji

Gene

JARID2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 122 (01 Oct 2014)
      Sequence version 2 (15 Mar 2005)
      Previous versions | rss
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    Functioni

    Regulator of histone methyltransferase complexes that plays an essential role in embryonic development, including heart and liver development, neural tube fusion process and hematopoiesis. Acts by modulating histone methyltransferase activity and promoting the recruitment of histone methyltransferase complexes to their target genes. Binds DNA and mediates the recruitment of the PRC2 complex to target genes in embryonic stem cells. Does not have histone demethylase activity but regulates activity of various histone methyltransferase complexes. In embryonic stem cells, it associates with the PRC2 complex and inhibits trimethylation of 'Lys-27' of histone H3 (H3K27me3) by the PRC2 complex, thereby playing a key role in differentiation of embryonic stem cells and normal development. In cardiac cells, it is required to repress expression of cyclin-D1 (CCND1) by activating methylation of 'Lys-9' of histone H3 (H3K9me) by the GLP1/EHMT1 and G9a/EHMT2 histone methyltransferases. Also acts as a transcriptional repressor of ANF via its interaction with GATA4 and NKX2-5. Participates in the negative regulation of cell proliferation signaling.1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: UniProtKB
    2. DNA binding Source: Ensembl

    GO - Biological processi

    1. central nervous system development Source: ProtInc
    2. chromatin modification Source: UniProtKB-KW
    3. liver development Source: Ensembl
    4. negative regulation of cell proliferation Source: Ensembl
    5. negative regulation of histone methylation Source: UniProtKB
    6. negative regulation of transcription, DNA-templated Source: UniProtKB
    7. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    8. positive regulation of histone H3-K9 methylation Source: UniProtKB
    9. spleen development Source: Ensembl
    10. stem cell differentiation Source: UniProtKB
    11. thymus development Source: Ensembl
    12. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Developmental protein, Repressor

    Keywords - Biological processi

    Differentiation, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_200808. PRC2 methylates histones and DNA.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein Jumonji
    Alternative name(s):
    Jumonji/ARID domain-containing protein 2
    Gene namesi
    Name:JARID2
    Synonyms:JMJ
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:6196. JARID2.

    Subcellular locationi

    Nucleus 1 PublicationPROSITE-ProRule annotation
    Note: Colocalizes with the PRC2 complex on chromatin.

    GO - Cellular componenti

    1. histone methyltransferase complex Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29995.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 12461246Protein JumonjiPRO_0000200591Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei78 – 781Phosphoserine1 Publication
    Modified residuei378 – 3781N6-acetyllysine1 Publication
    Modified residuei455 – 4551Phosphoserine1 Publication

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92833.
    PaxDbiQ92833.
    PRIDEiQ92833.

    PTM databases

    PhosphoSiteiQ92833.

    Expressioni

    Tissue specificityi

    During embryogenesis, predominantly expressed in neurons and particularly in dorsal root ganglion cells.

    Gene expression databases

    ArrayExpressiQ92833.
    BgeeiQ92833.
    CleanExiHS_JARID2.
    GenevestigatoriQ92833.

    Organism-specific databases

    HPAiHPA044909.

    Interactioni

    Subunit structurei

    Associates with a histone methyltransferase complex containing GLP1/EHMT1 and G9a/EHMT2. Interacts with SUZ12; the interaction is direct. Interacts with GATA4 (via the N-terminal region). Interacts with NKX2-5 (via the C-terminal region). Interacts with RB1. Interacts with ZNF496 By similarity. Associates with the PRC2 complex, which includes EED, EZH1, EZH2, SUZ12, RBBP4 and AEBP2; JARID2 is probably not a core component of the PRC2 complex and associates to PRC2 via its interaction with SUZ12.By similarity

    Protein-protein interaction databases

    BioGridi109923. 10 interactions.
    DIPiDIP-45494N.
    IntActiQ92833. 3 interactions.
    STRINGi9606.ENSP00000341280.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92833.
    SMRiQ92833. Positions 554-732, 805-1070.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini557 – 59842JmjNPROSITE-ProRule annotationAdd
    BLAST
    Domaini621 – 71393ARIDPROSITE-ProRule annotationAdd
    BLAST
    Domaini884 – 1048165JmjCPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi104 – 1107Nuclear localization signalBy similarity
    Motifi874 – 8785GSGFP motif

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1234 – 124613Poly-SerAdd
    BLAST

    Domaini

    The ARID domain is required to target the PRC2 complex to its target genes.By similarity
    The GSGFP motif is required for the interaction with SUZ12.By similarity

    Sequence similaritiesi

    Contains 1 ARID domain.PROSITE-ProRule annotation
    Contains 1 JmjC domain.PROSITE-ProRule annotation
    Contains 1 JmjN domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG327026.
    HOGENOMiHOG000013203.
    HOVERGENiHBG052160.
    InParanoidiQ92833.
    KOiK11478.
    OMAiWAAMDEI.
    OrthoDBiEOG76MK7F.
    PhylomeDBiQ92833.
    TreeFamiTF323264.

    Family and domain databases

    Gene3Di1.10.150.60. 1 hit.
    InterProiIPR001606. ARID/BRIGHT_DNA-bd.
    IPR003347. JmjC_dom.
    IPR003349. TF_JmjN.
    IPR004198. Znf_C5HC2.
    [Graphical view]
    PfamiPF01388. ARID. 1 hit.
    PF02373. JmjC. 1 hit.
    PF02375. JmjN. 1 hit.
    PF02928. zf-C5HC2. 1 hit.
    [Graphical view]
    SMARTiSM00501. BRIGHT. 1 hit.
    SM00558. JmjC. 1 hit.
    SM00545. JmjN. 1 hit.
    [Graphical view]
    SUPFAMiSSF46774. SSF46774. 1 hit.
    PROSITEiPS51011. ARID. 1 hit.
    PS51184. JMJC. 1 hit.
    PS51183. JMJN. 1 hit.
    [Graphical view]

    Sequences (3)i

    Sequence statusi: Complete.

    This entry describes 3 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92833-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSKERPKRNI IQKKYDDSDG IPWSEERVVR KVLYLSLKEF KNSQKRQHAE     50
    GIAGSLKTVN GLLGNDQSKG LGPASEQSEN EKDDASQVSS TSNDVSSSDF 100
    EEGPSRKRPR LQAQRKFAQS QPNSPSTTPV KIVEPLLPPP ATQISDLSKR 150
    KPKTEDFLTF LCLRGSPALP NSMVYFGSSQ DEEEVEEEDD ETEDVKTATN 200
    NASSSCQSTP RKGKTHKHVH NGHVFNGSSR STREKEPVQK HKSKEATPAK 250
    EKHSDHRADS RREQASANHP AAAPSTGSSA KGLAATHHHP PLHRSAQDLR 300
    KQVSKVNGVT RMSSLGAGVT SAKKMREVRP SPSKTVKYTA TVTKGAVTYT 350
    KAKRELVKDT KPNHHKPSSA VNHTISGKTE SSNAKTRKQV LSLGGASKST 400
    GPAVNGLKVS GRLNPKSCTK EVGGRQLREG LQLREGLRNS KRRLEEAHQA 450
    EKPQSPPKKM KGAAGPAEGP GKKAPAERGL LNGHVKKEVP ERSLERNRPK 500
    RATAGKSTPG RQAHGKADSA SCENRSTSQP ESVHKPQDSG KAEKGGGKAG 550
    WAAMDEIPVL RPSAKEFHDP LIYIESVRAQ VEKFGMCRVI PPPDWRPECK 600
    LNDEMRFVTQ IQHIHKLGRR WGPNVQRLAC IKKHLKSQGI TMDELPLIGG 650
    CELDLACFFR LINEMGGMQQ VTDLKKWNKL ADMLRIPRTA QDRLAKLQEA 700
    YCQYLLSYDS LSPEEHRRLE KEVLMEKEIL EKRKGPLEGH TENDHHKFHP 750
    LPRFEPKNGL IHGVAPRNGF RSKLKEVGQA QLKTGRRRLF AQEKEVVKEE 800
    EEDKGVLNDF HKCIYKGRSV SLTTFYRTAR NIMSMCFSKE PAPAEIEQEY 850
    WRLVEEKDCH VAVHCGKVDT NTHGSGFPVG KSEPFSRHGW NLTVLPNNTG 900
    SILRHLGAVP GVTIPWLNIG MVFSTSCWSR DQNHLPYIDY LHTGADCIWY 950
    CIPAEEENKL EDVVHTLLQA NGTPGLQMLE SNVMISPEVL CKEGIKVHRT 1000
    VQQSGQFVVC FPGSFVSKVC CGYSVSETVH FATTQWTSMG FETAKEMKRR 1050
    HIAKPFSMEK LLYQIAQAEA KKENGPTLST ISALLDELRD TELRQRRQLF 1100
    EAGLHSSARY GSHDGSSTVA DGKKKPRKWL QLETSERRCQ ICQHLCYLSM 1150
    VVQENENVVF CLECALRHVE KQKSCRGLKL MYRYDEEQII SLVNQICGKV 1200
    SGKNGSIENC LSKPTPKRGP RKRATVDVPP SRLSASSSSK SASSSS 1246
    Length:1,246
    Mass (Da):138,734
    Last modified:March 15, 2005 - v2
    Checksum:iE4929984259110DB
    GO
    Isoform 2 (identifier: Q92833-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-60: MSKERPKRNI...GIAGSLKTVN → MAAPRVCQVQFLVAYLEEPGIE
         949-1246: WYCIPAEEEN...SSSKSASSSS → CLSVEPVFPH...AWRGVLGPRL

    Note: No experimental confirmation available.

    Show »
    Length:960
    Mass (Da):106,139
    Checksum:i985C77D3B34F699B
    GO
    Isoform 3 (identifier: Q92833-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-172: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,074
    Mass (Da):119,689
    Checksum:iA913DFCF25573C4A
    GO

    Sequence cautioni

    The sequence AAC50822.1 differs from that shown. Reason: Frameshift at position 1233.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti250 – 2501K → E in BAH13011. (PubMed:14702039)Curated
    Sequence conflicti599 – 5991C → S in BAH13011. (PubMed:14702039)Curated
    Sequence conflicti673 – 6731D → E in AAC50822. (PubMed:8894700)Curated
    Sequence conflicti681 – 6811A → S in AAC50822. (PubMed:8894700)Curated
    Sequence conflicti688 – 6881R → K in AAC50822. (PubMed:8894700)Curated
    Sequence conflicti692 – 6921D → E in AAC50822. (PubMed:8894700)Curated
    Sequence conflicti705 – 7051L → I in AAC50822. (PubMed:8894700)Curated
    Sequence conflicti754 – 7541F → L in AAC50822. (PubMed:8894700)Curated
    Sequence conflicti1212 – 12121S → H in AAC50822. (PubMed:8894700)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 172172Missing in isoform 3. 1 PublicationVSP_045041Add
    BLAST
    Alternative sequencei1 – 6060MSKER…LKTVN → MAAPRVCQVQFLVAYLEEPG IE in isoform 2. 1 PublicationVSP_038756Add
    BLAST
    Alternative sequencei949 – 1246298WYCIP…ASSSS → CLSVEPVFPHLSVAVGSIVD LGISFLPCGDTRVMYPVESV AWRGVLGPRL in isoform 2. 1 PublicationVSP_038757Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57592 mRNA. Translation: AAC50822.1. Frameshift.
    AK292861 mRNA. Translation: BAF85550.1.
    AK299349 mRNA. Translation: BAH13011.1.
    AK303610 mRNA. Translation: BAH13996.1.
    AL136162, AL021938 Genomic DNA. Translation: CAI15719.1.
    AL021938, AL136162 Genomic DNA. Translation: CAI19873.1.
    CH471087 Genomic DNA. Translation: EAW55357.1.
    BC046184 mRNA. Translation: AAH46184.1.
    BC046246 mRNA. Translation: AAH46246.1.
    CCDSiCCDS4533.1. [Q92833-1]
    CCDS58996.1. [Q92833-3]
    RefSeqiNP_001253969.1. NM_001267040.1. [Q92833-3]
    NP_004964.2. NM_004973.3. [Q92833-1]
    XP_005249146.1. XM_005249089.1. [Q92833-3]
    UniGeneiHs.269059.

    Genome annotation databases

    EnsembliENST00000341776; ENSP00000341280; ENSG00000008083. [Q92833-1]
    ENST00000397311; ENSP00000380478; ENSG00000008083. [Q92833-3]
    GeneIDi3720.
    KEGGihsa:3720.
    UCSCiuc003nbj.4. human. [Q92833-1]

    Polymorphism databases

    DMDMi61252601.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57592 mRNA. Translation: AAC50822.1 . Frameshift.
    AK292861 mRNA. Translation: BAF85550.1 .
    AK299349 mRNA. Translation: BAH13011.1 .
    AK303610 mRNA. Translation: BAH13996.1 .
    AL136162 , AL021938 Genomic DNA. Translation: CAI15719.1 .
    AL021938 , AL136162 Genomic DNA. Translation: CAI19873.1 .
    CH471087 Genomic DNA. Translation: EAW55357.1 .
    BC046184 mRNA. Translation: AAH46184.1 .
    BC046246 mRNA. Translation: AAH46246.1 .
    CCDSi CCDS4533.1. [Q92833-1 ]
    CCDS58996.1. [Q92833-3 ]
    RefSeqi NP_001253969.1. NM_001267040.1. [Q92833-3 ]
    NP_004964.2. NM_004973.3. [Q92833-1 ]
    XP_005249146.1. XM_005249089.1. [Q92833-3 ]
    UniGenei Hs.269059.

    3D structure databases

    ProteinModelPortali Q92833.
    SMRi Q92833. Positions 554-732, 805-1070.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109923. 10 interactions.
    DIPi DIP-45494N.
    IntActi Q92833. 3 interactions.
    STRINGi 9606.ENSP00000341280.

    PTM databases

    PhosphoSitei Q92833.

    Polymorphism databases

    DMDMi 61252601.

    Proteomic databases

    MaxQBi Q92833.
    PaxDbi Q92833.
    PRIDEi Q92833.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000341776 ; ENSP00000341280 ; ENSG00000008083 . [Q92833-1 ]
    ENST00000397311 ; ENSP00000380478 ; ENSG00000008083 . [Q92833-3 ]
    GeneIDi 3720.
    KEGGi hsa:3720.
    UCSCi uc003nbj.4. human. [Q92833-1 ]

    Organism-specific databases

    CTDi 3720.
    GeneCardsi GC06P015246.
    HGNCi HGNC:6196. JARID2.
    HPAi HPA044909.
    MIMi 601594. gene.
    neXtProti NX_Q92833.
    PharmGKBi PA29995.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG327026.
    HOGENOMi HOG000013203.
    HOVERGENi HBG052160.
    InParanoidi Q92833.
    KOi K11478.
    OMAi WAAMDEI.
    OrthoDBi EOG76MK7F.
    PhylomeDBi Q92833.
    TreeFami TF323264.

    Enzyme and pathway databases

    Reactomei REACT_200808. PRC2 methylates histones and DNA.

    Miscellaneous databases

    GeneWikii JARID2.
    GenomeRNAii 3720.
    NextBioi 14577.
    PROi Q92833.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92833.
    Bgeei Q92833.
    CleanExi HS_JARID2.
    Genevestigatori Q92833.

    Family and domain databases

    Gene3Di 1.10.150.60. 1 hit.
    InterProi IPR001606. ARID/BRIGHT_DNA-bd.
    IPR003347. JmjC_dom.
    IPR003349. TF_JmjN.
    IPR004198. Znf_C5HC2.
    [Graphical view ]
    Pfami PF01388. ARID. 1 hit.
    PF02373. JmjC. 1 hit.
    PF02375. JmjN. 1 hit.
    PF02928. zf-C5HC2. 1 hit.
    [Graphical view ]
    SMARTi SM00501. BRIGHT. 1 hit.
    SM00558. JmjC. 1 hit.
    SM00545. JmjN. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46774. SSF46774. 1 hit.
    PROSITEi PS51011. ARID. 1 hit.
    PS51184. JMJC. 1 hit.
    PS51183. JMJN. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1; 2 AND 3).
      Tissue: Thymus and Trachea.
    3. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Mammary gland and Testis.
    6. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-378, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    7. "JARID2 regulates binding of the Polycomb repressive complex 2 to target genes in ES cells."
      Pasini D., Cloos P.A., Walfridsson J., Olsson L., Bukowski J.P., Johansen J.V., Bak M., Tommerup N., Rappsilber J., Helin K.
      Nature 464:306-310(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, SUBCELLULAR LOCATION, ASSOCIATION WITH THE PRC2 COMPLEX.
    8. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-78 AND SER-455, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

    Entry informationi

    Entry nameiJARD2_HUMAN
    AccessioniPrimary (citable) accession number: Q92833
    Secondary accession number(s): A8K9Z6
    , B7Z5S5, B7Z8L0, Q5U5L5, Q86X63
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: March 15, 2005
    Last modified: October 1, 2014
    This is version 122 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3