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Q92832

- NELL1_HUMAN

UniProt

Q92832 - NELL1_HUMAN

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Protein

Protein kinase C-binding protein NELL1

Gene

NELL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

GO - Molecular functioni

  1. calcium ion binding Source: InterPro

GO - Biological processi

  1. cell differentiation Source: UniProtKB-KW
  2. negative regulation of cyclin catabolic process Source: UniProtKB
  3. negative regulation of osteoblast proliferation Source: UniProtKB
  4. nervous system development Source: ProtInc
  5. positive regulation of bone mineralization Source: UniProtKB
  6. positive regulation of osteoblast differentiation Source: UniProtKB
  7. regulation of gene expression Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Differentiation

Keywords - Ligandi

Calcium

Names & Taxonomyi

Protein namesi
Recommended name:
Protein kinase C-binding protein NELL1
Alternative name(s):
NEL-like protein 1
Nel-related protein 1
Gene namesi
Name:NELL1
Synonyms:NRP1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 11

Organism-specific databases

HGNCiHGNC:7750. NELL1.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus envelope 1 Publication. Secreted By similarity
Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular region Source: UniProtKB-KW
  3. nuclear envelope Source: UniProtKB
  4. perinuclear region of cytoplasm Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31552.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence AnalysisAdd
BLAST
Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000007664Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi395 ↔ 407PROSITE-ProRule annotation
Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
Disulfide bondi418 ↔ 432PROSITE-ProRule annotation
Disulfide bondi438 ↔ 451PROSITE-ProRule annotation
Disulfide bondi445 ↔ 460PROSITE-ProRule annotation
Disulfide bondi462 ↔ 474PROSITE-ProRule annotation
Disulfide bondi480 ↔ 493PROSITE-ProRule annotation
Disulfide bondi487 ↔ 502PROSITE-ProRule annotation
Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi519 ↔ 529PROSITE-ProRule annotation
Disulfide bondi523 ↔ 535PROSITE-ProRule annotation
Disulfide bondi537 ↔ 546PROSITE-ProRule annotation
Disulfide bondi553 ↔ 566PROSITE-ProRule annotation
Disulfide bondi560 ↔ 575PROSITE-ProRule annotation
Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi577 ↔ 594PROSITE-ProRule annotation
Disulfide bondi600 ↔ 613PROSITE-ProRule annotation
Disulfide bondi607 ↔ 622PROSITE-ProRule annotation
Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi624 ↔ 630PROSITE-ProRule annotation
Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis
Glycosylationi732 – 7321N-linked (GlcNAc...)Sequence Analysis
Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ92832.
PRIDEiQ92832.

PTM databases

PhosphoSiteiQ92832.

Expressioni

Gene expression databases

BgeeiQ92832.
CleanExiHS_NELL1.
HS_NRP1.
ExpressionAtlasiQ92832. baseline and differential.
GenevestigatoriQ92832.

Organism-specific databases

HPAiHPA051535.

Interactioni

Subunit structurei

Homotrimer. Binds to PKC beta-1 (By similarity). Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ATRAIDQ6UW564EBI-947754,EBI-723802

Protein-protein interaction databases

BioGridi110820. 4 interactions.
IntActiQ92832. 17 interactions.
MINTiMINT-7034527.
STRINGi9606.ENSP00000298925.

Structurei

3D structure databases

ProteinModelPortaliQ92832.
SMRiQ92832. Positions 296-627.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini64 – 227164Laminin G-likeAdd
BLAST
Domaini271 – 33262VWFC 1PROSITE-ProRule annotationAdd
BLAST
Domaini434 – 47542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini476 – 51641EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini517 – 54731EGF-like 3PROSITE-ProRule annotationAdd
BLAST
Domaini549 – 58739EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini596 – 63136EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini692 – 75059VWFC 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 EGF-like domains.PROSITE-ProRule annotation
Contains 1 laminin G-like domain.Curated
Contains 2 VWFC domains.PROSITE-ProRule annotation

Keywords - Domaini

EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiNOG253557.
GeneTreeiENSGT00750000117321.
HOGENOMiHOG000217920.
HOVERGENiHBG004805.
InParanoidiQ92832.
PhylomeDBiQ92832.
TreeFamiTF323325.

Family and domain databases

Gene3Di2.60.120.200. 2 hits.
InterProiIPR026823. cEGF.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view]
PfamiPF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view]
SMARTiSM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view]
SUPFAMiSSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92832-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPMDLILVVW FCVCTARTVV GFGMDPDLQM DIVTELDLVN TTLGVAQVSG
60 70 80 90 100
MHNASKAFLF QDIEREIHAA PHVSEKLIQL FRNKSEFTIL ATVQQKPSTS
110 120 130 140 150
GVILSIRELE HSYFELESSG LRDEIRYHYI HNGKPRTEAL PYRMADGQWH
160 170 180 190 200
KVALSVSASH LLLHVDCNRI YERVIDPPDT NLPPGINLWL GQRNQKHGLF
210 220 230 240 250
KGIIQDGKII FMPNGYITQC PNLNHTCPTC SDFLSLVQGI MDLQELLAKM
260 270 280 290 300
TAKLNYAETR LSQLENCHCE KTCQVSGLLY RDQDSWVDGD HCRNCTCKSG
310 320 330 340 350
AVECRRMSCP PLNCSPDSLP VHIAGQCCKV CRPKCIYGGK VLAEGQRILT
360 370 380 390 400
KSCRECRGGV LVKITEMCPP LNCSEKDHIL PENQCCRVCR GHNFCAEGPK
410 420 430 440 450
CGENSECKNW NTKATCECKS GYISVQGDSA YCEDIDECAA KMHYCHANTV
460 470 480 490 500
CVNLPGLYRC DCVPGYIRVD DFSCTEHDEC GSGQHNCDEN AICTNTVQGH
510 520 530 540 550
SCTCKPGYVG NGTICRAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI
560 570 580 590 600
DECSEGIIEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC
610 620 630 640 650
ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWTLK
660 670 680 690 700
EDRCSVCSCK DGKIFCRRTA CDCQNPSADL FCCPECDTRV TSQCLDQNGH
710 720 730 740 750
KLYRSGDNWT HSCQQCRCLE GEVDCWPLTC PNLSCEYTAI LEGECCPRCV
760 770 780 790 800
SDPCLADNIT YDIRKTCLDS YGVSRLSGSV WTMAGSPCTT CKCKNGRVCC
810
SVDFECLQNN
Length:810
Mass (Da):89,635
Last modified:November 2, 2010 - v4
Checksum:i15E09F9954DA8629
GO
Isoform 2 (identifier: Q92832-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     549-595: Missing.

Show »
Length:763
Mass (Da):84,377
Checksum:i995411ADB36FAD7D
GO

Sequence cautioni

The sequence AAB06946.1 differs from that shown. Reason: Frameshift at positions 426 and 771.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti383 – 3831N → D in AAB06946. 1 PublicationCurated
Sequence conflicti573 – 5731Y → H in AAB06946. 1 PublicationCurated
Sequence conflicti626 – 6261S → C in AAB06946. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti82 – 821R → Q.4 Publications
Corresponds to variant rs8176785 [ dbSNP | Ensembl ].
VAR_047828
Natural varianti211 – 2111F → V.
Corresponds to variant rs35809043 [ dbSNP | Ensembl ].
VAR_047829
Natural varianti287 – 2871V → I.
Corresponds to variant rs11820003 [ dbSNP | Ensembl ].
VAR_047830
Natural varianti354 – 3541R → W.
Corresponds to variant rs8176786 [ dbSNP | Ensembl ].
VAR_020167
Natural varianti553 – 5531C → F in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035834

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei549 – 59547Missing in isoform 2. 1 PublicationVSP_039954Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83017 mRNA. Translation: BAA11680.1.
AK313445 mRNA. Translation: BAG36234.1.
EU518937 Genomic DNA. Translation: ACB21040.1.
AC010811 Genomic DNA. No translation available.
AC067794 Genomic DNA. No translation available.
AC069575 Genomic DNA. No translation available.
AC087279 Genomic DNA. No translation available.
AC090707 Genomic DNA. No translation available.
AC090857 Genomic DNA. No translation available.
AC099730 Genomic DNA. No translation available.
AC105190 Genomic DNA. No translation available.
AC108460 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68328.1.
BC069674 mRNA. Translation: AAH69674.1.
BC096100 mRNA. Translation: AAH96100.1.
BC096101 mRNA. Translation: AAH96101.1.
BC096102 mRNA. Translation: AAH96102.1.
U57523 mRNA. Translation: AAB06946.1. Frameshift.
CCDSiCCDS44555.1. [Q92832-2]
CCDS7855.1. [Q92832-1]
RefSeqiNP_001275642.1. NM_001288713.1.
NP_001275643.1. NM_001288714.1.
NP_006148.2. NM_006157.4. [Q92832-1]
NP_963845.1. NM_201551.2. [Q92832-2]
UniGeneiHs.657172.

Genome annotation databases

EnsembliENST00000357134; ENSP00000349654; ENSG00000165973. [Q92832-1]
ENST00000532434; ENSP00000437170; ENSG00000165973. [Q92832-2]
GeneIDi4745.
KEGGihsa:4745.
UCSCiuc001mqe.3. human. [Q92832-1]
uc001mqf.3. human. [Q92832-2]

Polymorphism databases

DMDMi311033486.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
D83017 mRNA. Translation: BAA11680.1 .
AK313445 mRNA. Translation: BAG36234.1 .
EU518937 Genomic DNA. Translation: ACB21040.1 .
AC010811 Genomic DNA. No translation available.
AC067794 Genomic DNA. No translation available.
AC069575 Genomic DNA. No translation available.
AC087279 Genomic DNA. No translation available.
AC090707 Genomic DNA. No translation available.
AC090857 Genomic DNA. No translation available.
AC099730 Genomic DNA. No translation available.
AC105190 Genomic DNA. No translation available.
AC108460 Genomic DNA. No translation available.
CH471064 Genomic DNA. Translation: EAW68328.1 .
BC069674 mRNA. Translation: AAH69674.1 .
BC096100 mRNA. Translation: AAH96100.1 .
BC096101 mRNA. Translation: AAH96101.1 .
BC096102 mRNA. Translation: AAH96102.1 .
U57523 mRNA. Translation: AAB06946.1 . Frameshift.
CCDSi CCDS44555.1. [Q92832-2 ]
CCDS7855.1. [Q92832-1 ]
RefSeqi NP_001275642.1. NM_001288713.1.
NP_001275643.1. NM_001288714.1.
NP_006148.2. NM_006157.4. [Q92832-1 ]
NP_963845.1. NM_201551.2. [Q92832-2 ]
UniGenei Hs.657172.

3D structure databases

ProteinModelPortali Q92832.
SMRi Q92832. Positions 296-627.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110820. 4 interactions.
IntActi Q92832. 17 interactions.
MINTi MINT-7034527.
STRINGi 9606.ENSP00000298925.

PTM databases

PhosphoSitei Q92832.

Polymorphism databases

DMDMi 311033486.

Proteomic databases

PaxDbi Q92832.
PRIDEi Q92832.

Protocols and materials databases

DNASUi 4745.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000357134 ; ENSP00000349654 ; ENSG00000165973 . [Q92832-1 ]
ENST00000532434 ; ENSP00000437170 ; ENSG00000165973 . [Q92832-2 ]
GeneIDi 4745.
KEGGi hsa:4745.
UCSCi uc001mqe.3. human. [Q92832-1 ]
uc001mqf.3. human. [Q92832-2 ]

Organism-specific databases

CTDi 4745.
GeneCardsi GC11P020647.
H-InvDB HIX0009505.
HGNCi HGNC:7750. NELL1.
HPAi HPA051535.
MIMi 602319. gene.
neXtProti NX_Q92832.
PharmGKBi PA31552.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG253557.
GeneTreei ENSGT00750000117321.
HOGENOMi HOG000217920.
HOVERGENi HBG004805.
InParanoidi Q92832.
PhylomeDBi Q92832.
TreeFami TF323325.

Miscellaneous databases

GeneWikii NELL1.
GenomeRNAii 4745.
NextBioi 18292.
PROi Q92832.
SOURCEi Search...

Gene expression databases

Bgeei Q92832.
CleanExi HS_NELL1.
HS_NRP1.
ExpressionAtlasi Q92832. baseline and differential.
Genevestigatori Q92832.

Family and domain databases

Gene3Di 2.60.120.200. 2 hits.
InterProi IPR026823. cEGF.
IPR013320. ConA-like_dom.
IPR000742. EG-like_dom.
IPR001881. EGF-like_Ca-bd_dom.
IPR013032. EGF-like_CS.
IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
IPR018097. EGF_Ca-bd_CS.
IPR024731. EGF_dom_MSP1-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR001791. Laminin_G.
IPR001007. VWF_C.
[Graphical view ]
Pfami PF12662. cEGF. 1 hit.
PF12947. EGF_3. 1 hit.
PF07645. EGF_CA. 1 hit.
PF12661. hEGF. 1 hit.
PF02210. Laminin_G_2. 1 hit.
PF00093. VWC. 2 hits.
[Graphical view ]
SMARTi SM00181. EGF. 3 hits.
SM00179. EGF_CA. 2 hits.
SM00282. LamG. 1 hit.
SM00210. TSPN. 1 hit.
SM00214. VWC. 3 hits.
[Graphical view ]
SUPFAMi SSF49899. SSF49899. 1 hit.
SSF57184. SSF57184. 1 hit.
PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
PS00022. EGF_1. 1 hit.
PS01186. EGF_2. 3 hits.
PS50026. EGF_3. 5 hits.
PS01187. EGF_CA. 3 hits.
PS01208. VWFC_1. 2 hits.
PS50184. VWFC_2. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats."
    Watanabe T.K., Katagiri T., Suzuki M., Shimizu F., Fujiwara T., Kanemoto N., Nakamura Y., Hirai Y., Maekawa H., Takahashi E.
    Genomics 38:273-276(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-82.
    Tissue: Brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-82.
    Tissue: Amygdala.
  3. NIEHS SNPs program
    Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-82.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-82.
  7. "Nel homolog gene expression in craniofacial anomalies."
    Ting K., Vastardis H., Mulliken J.B., Bertolami C., Wen Z., Young M., Tieu A., Kwong E.
    Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 383-810 (ISOFORMS 1/2).
  8. "NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation."
    Zou X., Shen J., Chen F., Ting K., Zheng Z., Pang S., Zara J.N., Adams J.S., Soo C., Zhang X.
    FEBS Lett. 585:2410-2418(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION, INTERACTION WITH ATRAID, SUBCELLULAR LOCATION.
  9. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-553.

Entry informationi

Entry nameiNELL1_HUMAN
AccessioniPrimary (citable) accession number: Q92832
Secondary accession number(s): B2CKC1
, Q4VB90, Q4VB91, Q6NSY8, Q9Y472
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 2, 2010
Last modified: October 29, 2014
This is version 144 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3