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Q92832

- NELL1_HUMAN

UniProt

Q92832 - NELL1_HUMAN

Protein

Protein kinase C-binding protein NELL1

Gene

NELL1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 143 (01 Oct 2014)
      Sequence version 4 (02 Nov 2010)
      Previous versions | rss
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    Functioni

    Plays a role in the control of cell growth and differentiation. Promotes osteoblast cell differentiation and terminal mineralization.1 Publication

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. cell differentiation Source: UniProtKB-KW
    2. negative regulation of cyclin catabolic process Source: UniProtKB
    3. negative regulation of osteoblast proliferation Source: UniProtKB
    4. nervous system development Source: ProtInc
    5. positive regulation of bone mineralization Source: UniProtKB
    6. positive regulation of osteoblast differentiation Source: UniProtKB
    7. regulation of gene expression Source: UniProtKB

    Keywords - Biological processi

    Differentiation

    Keywords - Ligandi

    Calcium

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein kinase C-binding protein NELL1
    Alternative name(s):
    NEL-like protein 1
    Nel-related protein 1
    Gene namesi
    Name:NELL1
    Synonyms:NRP1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:7750. NELL1.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus envelope 1 Publication. Secreted By similarity
    Note: Colocalizes with ATRAID on the nuclear envelope and the perinuclear region.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular region Source: UniProtKB-SubCell
    3. nuclear envelope Source: UniProtKB
    4. perinuclear region of cytoplasm Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31552.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2121Sequence AnalysisAdd
    BLAST
    Chaini22 – 810789Protein kinase C-binding protein NELL1PRO_0000007664Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi40 – 401N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi53 – 531N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi224 – 2241N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi294 – 2941N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi372 – 3721N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi395 ↔ 407PROSITE-ProRule annotation
    Disulfide bondi401 ↔ 416PROSITE-ProRule annotation
    Disulfide bondi418 ↔ 432PROSITE-ProRule annotation
    Disulfide bondi438 ↔ 451PROSITE-ProRule annotation
    Disulfide bondi445 ↔ 460PROSITE-ProRule annotation
    Disulfide bondi462 ↔ 474PROSITE-ProRule annotation
    Disulfide bondi480 ↔ 493PROSITE-ProRule annotation
    Disulfide bondi487 ↔ 502PROSITE-ProRule annotation
    Disulfide bondi504 ↔ 515PROSITE-ProRule annotation
    Glycosylationi511 – 5111N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi519 ↔ 529PROSITE-ProRule annotation
    Disulfide bondi523 ↔ 535PROSITE-ProRule annotation
    Disulfide bondi537 ↔ 546PROSITE-ProRule annotation
    Disulfide bondi553 ↔ 566PROSITE-ProRule annotation
    Disulfide bondi560 ↔ 575PROSITE-ProRule annotation
    Glycosylationi562 – 5621N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi577 ↔ 594PROSITE-ProRule annotation
    Disulfide bondi600 ↔ 613PROSITE-ProRule annotation
    Disulfide bondi607 ↔ 622PROSITE-ProRule annotation
    Glycosylationi609 – 6091N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi624 ↔ 630PROSITE-ProRule annotation
    Glycosylationi708 – 7081N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi732 – 7321N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi758 – 7581N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Disulfide bond, Glycoprotein

    Proteomic databases

    PaxDbiQ92832.
    PRIDEiQ92832.

    PTM databases

    PhosphoSiteiQ92832.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92832.
    BgeeiQ92832.
    CleanExiHS_NELL1.
    HS_NRP1.
    GenevestigatoriQ92832.

    Organism-specific databases

    HPAiHPA051535.

    Interactioni

    Subunit structurei

    Homotrimer. Binds to PKC beta-1 By similarity. Interacts with ATRAID; the interaction promotes osteoblast cell differentiation and mineralization.By similarity1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ATRAIDQ6UW564EBI-947754,EBI-723802

    Protein-protein interaction databases

    BioGridi110820. 4 interactions.
    IntActiQ92832. 17 interactions.
    MINTiMINT-7034527.
    STRINGi9606.ENSP00000298925.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92832.
    SMRiQ92832. Positions 296-627.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini64 – 227164Laminin G-likeAdd
    BLAST
    Domaini271 – 33262VWFC 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini434 – 47542EGF-like 1; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini476 – 51641EGF-like 2; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini517 – 54731EGF-like 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini549 – 58739EGF-like 4; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini596 – 63136EGF-like 5; calcium-bindingPROSITE-ProRule annotationAdd
    BLAST
    Domaini692 – 75059VWFC 2PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 EGF-like domains.PROSITE-ProRule annotation
    Contains 1 laminin G-like domain.Curated
    Contains 2 VWFC domains.PROSITE-ProRule annotation

    Keywords - Domaini

    EGF-like domain, Repeat, Signal

    Phylogenomic databases

    eggNOGiNOG253557.
    HOGENOMiHOG000217920.
    HOVERGENiHBG004805.
    InParanoidiQ92832.
    PhylomeDBiQ92832.
    TreeFamiTF323325.

    Family and domain databases

    Gene3Di2.60.120.200. 2 hits.
    InterProiIPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view]
    PfamiPF12662. cEGF. 1 hit.
    PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view]
    SMARTiSM00181. EGF. 3 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view]
    SUPFAMiSSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEiPS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92832-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPMDLILVVW FCVCTARTVV GFGMDPDLQM DIVTELDLVN TTLGVAQVSG    50
    MHNASKAFLF QDIEREIHAA PHVSEKLIQL FRNKSEFTIL ATVQQKPSTS 100
    GVILSIRELE HSYFELESSG LRDEIRYHYI HNGKPRTEAL PYRMADGQWH 150
    KVALSVSASH LLLHVDCNRI YERVIDPPDT NLPPGINLWL GQRNQKHGLF 200
    KGIIQDGKII FMPNGYITQC PNLNHTCPTC SDFLSLVQGI MDLQELLAKM 250
    TAKLNYAETR LSQLENCHCE KTCQVSGLLY RDQDSWVDGD HCRNCTCKSG 300
    AVECRRMSCP PLNCSPDSLP VHIAGQCCKV CRPKCIYGGK VLAEGQRILT 350
    KSCRECRGGV LVKITEMCPP LNCSEKDHIL PENQCCRVCR GHNFCAEGPK 400
    CGENSECKNW NTKATCECKS GYISVQGDSA YCEDIDECAA KMHYCHANTV 450
    CVNLPGLYRC DCVPGYIRVD DFSCTEHDEC GSGQHNCDEN AICTNTVQGH 500
    SCTCKPGYVG NGTICRAFCE EGCRYGGTCV APNKCVCPSG FTGSHCEKDI 550
    DECSEGIIEC HNHSRCVNLP GWYHCECRSG FHDDGTYSLS GESCIDIDEC 600
    ALRTHTCWND SACINLAGGF DCLCPSGPSC SGDCPHEGGL KHNGQVWTLK 650
    EDRCSVCSCK DGKIFCRRTA CDCQNPSADL FCCPECDTRV TSQCLDQNGH 700
    KLYRSGDNWT HSCQQCRCLE GEVDCWPLTC PNLSCEYTAI LEGECCPRCV 750
    SDPCLADNIT YDIRKTCLDS YGVSRLSGSV WTMAGSPCTT CKCKNGRVCC 800
    SVDFECLQNN 810
    Length:810
    Mass (Da):89,635
    Last modified:November 2, 2010 - v4
    Checksum:i15E09F9954DA8629
    GO
    Isoform 2 (identifier: Q92832-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         549-595: Missing.

    Show »
    Length:763
    Mass (Da):84,377
    Checksum:i995411ADB36FAD7D
    GO

    Sequence cautioni

    The sequence AAB06946.1 differs from that shown. Reason: Frameshift at positions 426 and 771.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti383 – 3831N → D in AAB06946. 1 PublicationCurated
    Sequence conflicti573 – 5731Y → H in AAB06946. 1 PublicationCurated
    Sequence conflicti626 – 6261S → C in AAB06946. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti82 – 821R → Q.4 Publications
    Corresponds to variant rs8176785 [ dbSNP | Ensembl ].
    VAR_047828
    Natural varianti211 – 2111F → V.
    Corresponds to variant rs35809043 [ dbSNP | Ensembl ].
    VAR_047829
    Natural varianti287 – 2871V → I.
    Corresponds to variant rs11820003 [ dbSNP | Ensembl ].
    VAR_047830
    Natural varianti354 – 3541R → W.
    Corresponds to variant rs8176786 [ dbSNP | Ensembl ].
    VAR_020167
    Natural varianti553 – 5531C → F in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035834

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei549 – 59547Missing in isoform 2. 1 PublicationVSP_039954Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83017 mRNA. Translation: BAA11680.1.
    AK313445 mRNA. Translation: BAG36234.1.
    EU518937 Genomic DNA. Translation: ACB21040.1.
    AC010811 Genomic DNA. No translation available.
    AC067794 Genomic DNA. No translation available.
    AC069575 Genomic DNA. No translation available.
    AC087279 Genomic DNA. No translation available.
    AC090707 Genomic DNA. No translation available.
    AC090857 Genomic DNA. No translation available.
    AC099730 Genomic DNA. No translation available.
    AC105190 Genomic DNA. No translation available.
    AC108460 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68328.1.
    BC069674 mRNA. Translation: AAH69674.1.
    BC096100 mRNA. Translation: AAH96100.1.
    BC096101 mRNA. Translation: AAH96101.1.
    BC096102 mRNA. Translation: AAH96102.1.
    U57523 mRNA. Translation: AAB06946.1. Frameshift.
    CCDSiCCDS44555.1. [Q92832-2]
    CCDS7855.1. [Q92832-1]
    RefSeqiNP_001275642.1. NM_001288713.1.
    NP_001275643.1. NM_001288714.1.
    NP_006148.2. NM_006157.4. [Q92832-1]
    NP_963845.1. NM_201551.2. [Q92832-2]
    UniGeneiHs.657172.

    Genome annotation databases

    EnsembliENST00000357134; ENSP00000349654; ENSG00000165973. [Q92832-1]
    ENST00000532434; ENSP00000437170; ENSG00000165973. [Q92832-2]
    GeneIDi4745.
    KEGGihsa:4745.
    UCSCiuc001mqe.3. human. [Q92832-1]
    uc001mqf.3. human. [Q92832-2]

    Polymorphism databases

    DMDMi311033486.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    D83017 mRNA. Translation: BAA11680.1 .
    AK313445 mRNA. Translation: BAG36234.1 .
    EU518937 Genomic DNA. Translation: ACB21040.1 .
    AC010811 Genomic DNA. No translation available.
    AC067794 Genomic DNA. No translation available.
    AC069575 Genomic DNA. No translation available.
    AC087279 Genomic DNA. No translation available.
    AC090707 Genomic DNA. No translation available.
    AC090857 Genomic DNA. No translation available.
    AC099730 Genomic DNA. No translation available.
    AC105190 Genomic DNA. No translation available.
    AC108460 Genomic DNA. No translation available.
    CH471064 Genomic DNA. Translation: EAW68328.1 .
    BC069674 mRNA. Translation: AAH69674.1 .
    BC096100 mRNA. Translation: AAH96100.1 .
    BC096101 mRNA. Translation: AAH96101.1 .
    BC096102 mRNA. Translation: AAH96102.1 .
    U57523 mRNA. Translation: AAB06946.1 . Frameshift.
    CCDSi CCDS44555.1. [Q92832-2 ]
    CCDS7855.1. [Q92832-1 ]
    RefSeqi NP_001275642.1. NM_001288713.1.
    NP_001275643.1. NM_001288714.1.
    NP_006148.2. NM_006157.4. [Q92832-1 ]
    NP_963845.1. NM_201551.2. [Q92832-2 ]
    UniGenei Hs.657172.

    3D structure databases

    ProteinModelPortali Q92832.
    SMRi Q92832. Positions 296-627.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110820. 4 interactions.
    IntActi Q92832. 17 interactions.
    MINTi MINT-7034527.
    STRINGi 9606.ENSP00000298925.

    PTM databases

    PhosphoSitei Q92832.

    Polymorphism databases

    DMDMi 311033486.

    Proteomic databases

    PaxDbi Q92832.
    PRIDEi Q92832.

    Protocols and materials databases

    DNASUi 4745.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000357134 ; ENSP00000349654 ; ENSG00000165973 . [Q92832-1 ]
    ENST00000532434 ; ENSP00000437170 ; ENSG00000165973 . [Q92832-2 ]
    GeneIDi 4745.
    KEGGi hsa:4745.
    UCSCi uc001mqe.3. human. [Q92832-1 ]
    uc001mqf.3. human. [Q92832-2 ]

    Organism-specific databases

    CTDi 4745.
    GeneCardsi GC11P020647.
    H-InvDB HIX0009505.
    HGNCi HGNC:7750. NELL1.
    HPAi HPA051535.
    MIMi 602319. gene.
    neXtProti NX_Q92832.
    PharmGKBi PA31552.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG253557.
    HOGENOMi HOG000217920.
    HOVERGENi HBG004805.
    InParanoidi Q92832.
    PhylomeDBi Q92832.
    TreeFami TF323325.

    Miscellaneous databases

    GeneWikii NELL1.
    GenomeRNAii 4745.
    NextBioi 18292.
    PROi Q92832.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92832.
    Bgeei Q92832.
    CleanExi HS_NELL1.
    HS_NRP1.
    Genevestigatori Q92832.

    Family and domain databases

    Gene3Di 2.60.120.200. 2 hits.
    InterProi IPR026823. cEGF.
    IPR008985. ConA-like_lec_gl_sf.
    IPR013320. ConA-like_subgrp.
    IPR000742. EG-like_dom.
    IPR001881. EGF-like_Ca-bd_dom.
    IPR013032. EGF-like_CS.
    IPR000152. EGF-type_Asp/Asn_hydroxyl_site.
    IPR018097. EGF_Ca-bd_CS.
    IPR024731. EGF_dom_MSP1-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR001791. Laminin_G.
    IPR001007. VWF_C.
    [Graphical view ]
    Pfami PF12662. cEGF. 1 hit.
    PF12947. EGF_3. 1 hit.
    PF07645. EGF_CA. 1 hit.
    PF12661. hEGF. 1 hit.
    PF02210. Laminin_G_2. 1 hit.
    PF00093. VWC. 2 hits.
    [Graphical view ]
    SMARTi SM00181. EGF. 3 hits.
    SM00179. EGF_CA. 2 hits.
    SM00282. LamG. 1 hit.
    SM00210. TSPN. 1 hit.
    SM00214. VWC. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49899. SSF49899. 1 hit.
    SSF57184. SSF57184. 1 hit.
    PROSITEi PS00010. ASX_HYDROXYL. 3 hits.
    PS00022. EGF_1. 1 hit.
    PS01186. EGF_2. 3 hits.
    PS50026. EGF_3. 5 hits.
    PS01187. EGF_CA. 3 hits.
    PS01208. VWFC_1. 2 hits.
    PS50184. VWFC_2. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of two novel human cDNAs (NELL1 and NELL2) encoding proteins with six EGF-like repeats."
      Watanabe T.K., Katagiri T., Suzuki M., Shimizu F., Fujiwara T., Kanemoto N., Nakamura Y., Hirai Y., Maekawa H., Takahashi E.
      Genomics 38:273-276(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), VARIANT GLN-82.
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1), VARIANT GLN-82.
      Tissue: Amygdala.
    3. NIEHS SNPs program
      Submitted (FEB-2008) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-82.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2), VARIANT GLN-82.
    7. "Nel homolog gene expression in craniofacial anomalies."
      Ting K., Vastardis H., Mulliken J.B., Bertolami C., Wen Z., Young M., Tieu A., Kwong E.
      Submitted (SEP-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 383-810 (ISOFORMS 1/2).
    8. "NELL-1 binds to APR3 affecting human osteoblast proliferation and differentiation."
      Zou X., Shen J., Chen F., Ting K., Zheng Z., Pang S., Zara J.N., Adams J.S., Soo C., Zhang X.
      FEBS Lett. 585:2410-2418(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN OSTEOBLAST DIFFERENTIATION, INTERACTION WITH ATRAID, SUBCELLULAR LOCATION.
    9. Cited for: VARIANT [LARGE SCALE ANALYSIS] PHE-553.

    Entry informationi

    Entry nameiNELL1_HUMAN
    AccessioniPrimary (citable) accession number: Q92832
    Secondary accession number(s): B2CKC1
    , Q4VB90, Q4VB91, Q6NSY8, Q9Y472
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: November 2, 2010
    Last modified: October 1, 2014
    This is version 143 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3