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Protein

Coronin-2A

Gene

CORO2A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

  • actin cytoskeleton organization Source: GO_Central
  • intracellular signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

SignaLinkiQ92828.

Names & Taxonomyi

Protein namesi
Recommended name:
Coronin-2A
Alternative name(s):
IR10
WD repeat-containing protein 2
Gene namesi
Name:CORO2A
Synonyms:IR10, WDR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:2255. CORO2A.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: GO_Central
  • transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26771.

Polymorphism and mutation databases

BioMutaiCORO2A.
DMDMi28381354.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 525525Coronin-2APRO_0000050928Add
BLAST

Proteomic databases

EPDiQ92828.
MaxQBiQ92828.
PaxDbiQ92828.
PRIDEiQ92828.

PTM databases

iPTMnetiQ92828.
PhosphoSiteiQ92828.

Expressioni

Gene expression databases

BgeeiQ92828.
CleanExiHS_CORO2A.
ExpressionAtlasiQ92828. baseline and differential.
GenevisibleiQ92828. HS.

Organism-specific databases

HPAiHPA041161.
HPA041302.

Interactioni

Subunit structurei

Binds actin (By similarity). Component of the N-Cor repressor complex, at least composed of NCOR1, NCOR2, HDAC3, TBL1X, TBL1R, CORO2A and GPS2.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi113302. 36 interactions.
DIPiDIP-59202N.
IntActiQ92828. 34 interactions.
STRINGi9606.ENSP00000343746.

Structurei

3D structure databases

ProteinModelPortaliQ92828.
SMRiQ92828. Positions 9-400.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati24 – 7148WD 1Add
BLAST
Repeati72 – 12251WD 2Add
BLAST
Repeati123 – 17048WD 3Add
BLAST
Repeati171 – 21444WD 4Add
BLAST
Repeati215 – 25945WD 5Add
BLAST
Repeati260 – 30546WD 6Add
BLAST
Repeati306 – 34237WD 7Add
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili485 – 52440Sequence analysisAdd
BLAST

Sequence similaritiesi

Belongs to the WD repeat coronin family.Curated
Contains 7 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ92828.
KOiK13887.
OMAiKKSWLTN.
OrthoDBiEOG7J70FB.
PhylomeDBiQ92828.
TreeFamiTF314280.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027335. CORO2A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF2. PTHR10856:SF2. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92828-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSWHPQYRSS KFRHVFGKPA SKENCYDSVP ITRSVHDNHF CAVNPHFIAV
60 70 80 90 100
VTECAGGGAF LVIPLHQTGK LDPHYPKVCG HRGNVLDVKW NPFDDFEIAS
110 120 130 140 150
CSEDATIKIW SIPKQLLTRN LTAYRKELVG HARRVGLVEW HPTAANILFS
160 170 180 190 200
AGYDYKVMIW NLDTKESVIT SPMSTISCHQ DVILSMSFNT NGSLLATTCK
210 220 230 240 250
DRKIRVIDPR AGTVLQEASY KGHRASKVLF LGNLKKLMST GTSRWNNRQV
260 270 280 290 300
ALWDQDNLSV PLMEEDLDGS SGVLFPFYDA DTSMLYVVGK GDGNIRYYEV
310 320 330 340 350
SADKPHLSYL TEYRSYNPQK GIGVMPKRGL DVSSCEIFRF YKLITTKSLI
360 370 380 390 400
EPISMIVPRR SESYQEDIYP PTAGAQPSLT AQEWLSGMNR DPILVSLRPG
410 420 430 440 450
SELLRPHPLP AERPIFNSMA PASPRLLNQT EKLAAEDGWR SSSLLEEKMP
460 470 480 490 500
RWAAEHRLEE KKTWLTNGFD VFECPPPKTE NELLQMFYRQ QEEIRRLREL
510 520
LTQREVQAKQ LELEIKNLRM GSEQL
Length:525
Mass (Da):59,763
Last modified:February 12, 2003 - v2
Checksum:i8546E1C5A78CB1FA
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti59 – 591A → G in AAB47807 (PubMed:8985118).Curated
Sequence conflicti88 – 881V → A in AAB47808 (PubMed:8985118).Curated
Sequence conflicti360 – 3601R → G in AAB47807 (PubMed:8985118).Curated
Sequence conflicti373 – 3731A → G in AAB47807 (PubMed:8985118).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti296 – 2961R → H.
Corresponds to variant rs2231666 [ dbSNP | Ensembl ].
VAR_053390
Natural varianti495 – 4951R → L.
Corresponds to variant rs35787916 [ dbSNP | Ensembl ].
VAR_053391

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57057 mRNA. Translation: AAB47807.1.
U57058 mRNA. Translation: AAB47808.1.
AL137073 Genomic DNA. Translation: CAI13893.1.
CH471105 Genomic DNA. Translation: EAW58879.1.
BC000010 mRNA. Translation: AAH00010.1.
BC011690 mRNA. Translation: AAH11690.1.
CCDSiCCDS6735.1.
RefSeqiNP_003380.3. NM_003389.3.
NP_438171.1. NM_052820.3.
XP_011517287.1. XM_011518985.1.
XP_011517288.1. XM_011518986.1.
UniGeneiHs.113094.

Genome annotation databases

EnsembliENST00000343933; ENSP00000343746; ENSG00000106789.
ENST00000375077; ENSP00000364218; ENSG00000106789.
GeneIDi7464.
KEGGihsa:7464.
UCSCiuc004ayl.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57057 mRNA. Translation: AAB47807.1.
U57058 mRNA. Translation: AAB47808.1.
AL137073 Genomic DNA. Translation: CAI13893.1.
CH471105 Genomic DNA. Translation: EAW58879.1.
BC000010 mRNA. Translation: AAH00010.1.
BC011690 mRNA. Translation: AAH11690.1.
CCDSiCCDS6735.1.
RefSeqiNP_003380.3. NM_003389.3.
NP_438171.1. NM_052820.3.
XP_011517287.1. XM_011518985.1.
XP_011517288.1. XM_011518986.1.
UniGeneiHs.113094.

3D structure databases

ProteinModelPortaliQ92828.
SMRiQ92828. Positions 9-400.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113302. 36 interactions.
DIPiDIP-59202N.
IntActiQ92828. 34 interactions.
STRINGi9606.ENSP00000343746.

PTM databases

iPTMnetiQ92828.
PhosphoSiteiQ92828.

Polymorphism and mutation databases

BioMutaiCORO2A.
DMDMi28381354.

Proteomic databases

EPDiQ92828.
MaxQBiQ92828.
PaxDbiQ92828.
PRIDEiQ92828.

Protocols and materials databases

DNASUi7464.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000343933; ENSP00000343746; ENSG00000106789.
ENST00000375077; ENSP00000364218; ENSG00000106789.
GeneIDi7464.
KEGGihsa:7464.
UCSCiuc004ayl.4. human.

Organism-specific databases

CTDi7464.
GeneCardsiCORO2A.
HGNCiHGNC:2255. CORO2A.
HPAiHPA041161.
HPA041302.
MIMi602159. gene.
neXtProtiNX_Q92828.
PharmGKBiPA26771.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0303. Eukaryota.
ENOG410XQAD. LUCA.
GeneTreeiENSGT00760000119195.
HOGENOMiHOG000166356.
HOVERGENiHBG059978.
InParanoidiQ92828.
KOiK13887.
OMAiKKSWLTN.
OrthoDBiEOG7J70FB.
PhylomeDBiQ92828.
TreeFamiTF314280.

Enzyme and pathway databases

SignaLinkiQ92828.

Miscellaneous databases

ChiTaRSiCORO2A. human.
GeneWikiiCORO2A.
GenomeRNAii7464.
NextBioi29230.
PROiQ92828.
SOURCEiSearch...

Gene expression databases

BgeeiQ92828.
CleanExiHS_CORO2A.
ExpressionAtlasiQ92828. baseline and differential.
GenevisibleiQ92828. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR027335. CORO2A.
IPR015505. Coronin.
IPR015048. DUF1899.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR019775. WD40_repeat_CS.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10856. PTHR10856. 1 hit.
PTHR10856:SF2. PTHR10856:SF2. 1 hit.
PfamiPF08953. DUF1899. 1 hit.
PF00400. WD40. 2 hits.
[Graphical view]
SMARTiSM01166. DUF1899. 1 hit.
SM00320. WD40. 4 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS00678. WD_REPEATS_1. 1 hit.
PS50082. WD_REPEATS_2. 3 hits.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning of a novel WD repeat protein mapping to the 9q22.3 chromosomal region."
    Zaphiropoulos P.G., Toftgard R.
    DNA Cell Biol. 15:1049-1056(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Epidermis.
  2. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Eye and Placenta.
  5. "Purification and functional characterization of the human N-CoR complex: the roles of HDAC3, TBL1 and TBLR1."
    Yoon H.-G., Chan D.W., Huang Z.-Q., Li J., Fondell J.D., Qin J., Wong J.
    EMBO J. 22:1336-1346(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: COMPONENT OF THE N-COR COMPLEX WITH TBL1R; TBL1X AND HDAC3.

Entry informationi

Entry nameiCOR2A_HUMAN
AccessioniPrimary (citable) accession number: Q92828
Secondary accession number(s): Q5TBR5, Q92829, Q9BWS5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 12, 2003
Last modified: May 11, 2016
This is version 146 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.