Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Homeobox protein Hox-B13

Gene

HOXB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi216 – 27560HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. sequence-specific DNA binding Source: InterPro

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. epidermis development Source: ProtInc
  3. epithelial cell maturation involved in prostate gland development Source: Ensembl
  4. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
  5. regulation of growth Source: Ensembl
  6. regulation of transcription, DNA-templated Source: UniProtKB-KW
  7. response to testosterone Source: Ensembl
  8. response to wounding Source: ProtInc
  9. transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B13
Gene namesi
Name:HOXB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5112. HOXB13.

Subcellular locationi

GO - Cellular componenti

  1. nucleoplasm Source: HPA
  2. transcription factor complex Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Prostate cancer (PC)4 Publications

Disease susceptibility is associated with variations affecting the gene represented in this entry.

Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.

See also OMIM:176807
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti84 – 841G → E in PC; rare variant associated with disease susceptibility. 4 Publications
VAR_071866

Keywords - Diseasei

Disease mutation

Organism-specific databases

MIMi176807. phenotype.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA29388.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 284284Homeobox protein Hox-B13PRO_0000200160Add
BLAST

Proteomic databases

MaxQBiQ92826.
PaxDbiQ92826.
PRIDEiQ92826.

PTM databases

PhosphoSiteiQ92826.

Expressioni

Gene expression databases

BgeeiQ92826.
CleanExiHS_HOXB13.
GenevestigatoriQ92826.

Organism-specific databases

HPAiCAB004438.
HPA051885.

Interactioni

Protein-protein interaction databases

BioGridi115744. 8 interactions.
STRINGi9606.ENSP00000290295.

Structurei

Secondary structure

1
284
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi225 – 23713Combined sources
Helixi243 – 25210Combined sources
Helixi257 – 26913Combined sources
Turni270 – 2723Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
ProteinModelPortaliQ92826.
SMRiQ92826. Positions 216-273.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92826.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiQ92826.
OMAiHPPDGCA.
OrthoDBiEOG7SJD53.
PhylomeDBiQ92826.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP
60 70 80 90 100
LDLPGSAEPP KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC
110 120 130 140 150
AQAATLAAYP AETPTAGEEY PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ
160 170 180 190 200
TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS QMCCQGEQNP PGPFWKAAFA
210 220 230 240 250
DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF ITKDKRRKIS
260 270 280
AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP
Length:284
Mass (Da):30,676
Last modified:July 18, 2004 - v2
Checksum:i3EE5898449C33CFE
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti138 – 1392QP → HA (PubMed:8756292).Curated
Sequence conflicti138 – 1392QP → HA (PubMed:9665387).Curated
Sequence conflicti211 – 2111C → S in AAC50664 (PubMed:8756292).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti41 – 411T → M.1 Publication
Corresponds to variant rs199799743 [ dbSNP | Ensembl ].
VAR_031849
Natural varianti84 – 841G → E in PC; rare variant associated with disease susceptibility. 4 Publications
VAR_071866
Natural varianti88 – 881Y → D Found in prostate cancer samples; unknown pathological significance. 1 Publication
VAR_071867
Natural varianti144 – 1441L → P Found in prostate cancer samples; unknown pathological significance. 1 Publication
VAR_071868
Natural varianti216 – 2161G → C Found in prostate cancer samples; unknown pathological significance. 1 Publication
VAR_071869
Natural varianti229 – 2291R → G Found in prostate cancer samples; unknown pathological significance. 1 Publication
VAR_071870

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA. Translation: AAC50664.1.
U81599 mRNA. Translation: AAB39863.1.
BT007410 mRNA. Translation: AAP36078.1.
AK313266 mRNA. Translation: BAG36075.1.
CH471109 Genomic DNA. Translation: EAW94714.1.
BC007092 mRNA. Translation: AAH07092.1.
BC070233 mRNA. Translation: AAH70233.1.
CCDSiCCDS11536.1.
RefSeqiNP_006352.2. NM_006361.5.
UniGeneiHs.66731.

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184.
GeneIDi10481.
KEGGihsa:10481.
UCSCiuc002ioa.3. human.

Polymorphism databases

DMDMi50403792.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA. Translation: AAC50664.1.
U81599 mRNA. Translation: AAB39863.1.
BT007410 mRNA. Translation: AAP36078.1.
AK313266 mRNA. Translation: BAG36075.1.
CH471109 Genomic DNA. Translation: EAW94714.1.
BC007092 mRNA. Translation: AAH07092.1.
BC070233 mRNA. Translation: AAH70233.1.
CCDSiCCDS11536.1.
RefSeqiNP_006352.2. NM_006361.5.
UniGeneiHs.66731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
ProteinModelPortaliQ92826.
SMRiQ92826. Positions 216-273.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115744. 8 interactions.
STRINGi9606.ENSP00000290295.

PTM databases

PhosphoSiteiQ92826.

Polymorphism databases

DMDMi50403792.

Proteomic databases

MaxQBiQ92826.
PaxDbiQ92826.
PRIDEiQ92826.

Protocols and materials databases

DNASUi10481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184.
GeneIDi10481.
KEGGihsa:10481.
UCSCiuc002ioa.3. human.

Organism-specific databases

CTDi10481.
GeneCardsiGC17M046802.
HGNCiHGNC:5112. HOXB13.
HPAiCAB004438.
HPA051885.
MIMi176807. phenotype.
604607. gene.
neXtProtiNX_Q92826.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA29388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG276440.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiQ92826.
OMAiHPPDGCA.
OrthoDBiEOG7SJD53.
PhylomeDBiQ92826.
TreeFamiTF330813.

Miscellaneous databases

ChiTaRSiHOXB13. human.
EvolutionaryTraceiQ92826.
GeneWikiiHOXB13.
GenomeRNAii10481.
NextBioi39762.
PROiQ92826.
SOURCEiSearch...

Gene expression databases

BgeeiQ92826.
CleanExiHS_HOXB13.
GenevestigatoriQ92826.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity."
    Zeltser L.M., Desplan C., Heintz N.
    Development 122:2475-2484(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds."
    Stelnicki E.J., Arbeit J., Cass D.L., Saner C., Harrison M., Largman C.
    J. Invest. Dermatol. 111:57-63(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (APR-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  7. "Solution structure of the homeobox domain of human homeo box B13."
    RIKEN structural genomics initiative (RSGI)
    Submitted (OCT-2005) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 216-273.
  8. Cited for: VARIANT MET-41.
  9. "Confirmation of the HOXB13 G84E germline mutation in familial prostate cancer."
    Breyer J.P., Avritt T.G., McReynolds K.M., Dupont W.D., Smith J.R.
    Cancer Epidemiol. Biomarkers Prev. 21:1348-1353(2011) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANT PC GLU-84.
  10. Cited for: INVOLVEMENT IN PC, VARIANT PC GLU-84, VARIANTS ASP-88; PRO-144; CYS-216 AND GLY-229.
  11. Cited for: INVOLVEMENT IN PC, VARIANT PC GLU-84.
  12. "HOXB13 is a susceptibility gene for prostate cancer: results from the international consortium for prostate cancer genetics (ICPCG)."
    International Consortium for Prostate Cancer Genetics
    Xu J., Lange E.M., Lu L., Zheng S.L., Wang Z., Thibodeau S.N., Cannon-Albright L.A., Teerlink C.C., Camp N.J., Johnson A.M., Zuhlke K.A., Stanford J.L., Ostrander E.A., Wiley K.E., Isaacs S.D., Walsh P.C., Maier C., Luedeke M.
    , Vogel W., Schleutker J., Wahlfors T., Tammela T., Schaid D., McDonnell S.K., DeRycke M.S., Cancel-Tassin G., Cussenot O., Wiklund F., Gronberg H., Eeles R., Easton D., Kote-Jarai Z., Whittemore A.S., Hsieh C.L., Giles G.G., Hopper J.L., Severi G., Catalona W.J., Mandal D., Ledet E., Foulkes W.D., Hamel N., Mahle L., Moller P., Powell I., Bailey-Wilson J.E., Carpten J.D., Seminara D., Cooney K.A., Isaacs W.B.
    Hum. Genet. 132:5-14(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: INVOLVEMENT IN PC, VARIANT PC GLU-84.

Entry informationi

Entry nameiHXB13_HUMAN
AccessioniPrimary (citable) accession number: Q92826
Secondary accession number(s): B2R878, Q96QM4, Q99810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 1997
Last sequence update: July 18, 2004
Last modified: February 3, 2015
This is version 142 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.