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Q92826

- HXB13_HUMAN

UniProt

Q92826 - HXB13_HUMAN

Protein

Homeobox protein Hox-B13

Gene

HOXB13

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 138 (01 Oct 2014)
      Sequence version 2 (19 Jul 2004)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi216 – 27560HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. epidermis development Source: ProtInc
    3. epithelial cell maturation involved in prostate gland development Source: Ensembl
    4. prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Source: Ensembl
    5. regulation of growth Source: Ensembl
    6. response to testosterone Source: Ensembl
    7. response to wounding Source: ProtInc
    8. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-B13
    Gene namesi
    Name:HOXB13
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:5112. HOXB13.

    Subcellular locationi

    GO - Cellular componenti

    1. nucleus Source: HPA
    2. transcription factor complex Source: Ensembl

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti1331. Familial prostate cancer.
    PharmGKBiPA29388.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 284284Homeobox protein Hox-B13PRO_0000200160Add
    BLAST

    Proteomic databases

    MaxQBiQ92826.
    PaxDbiQ92826.
    PRIDEiQ92826.

    PTM databases

    PhosphoSiteiQ92826.

    Expressioni

    Gene expression databases

    BgeeiQ92826.
    CleanExiHS_HOXB13.
    GenevestigatoriQ92826.

    Organism-specific databases

    HPAiCAB004438.
    HPA051885.

    Interactioni

    Protein-protein interaction databases

    BioGridi115744. 8 interactions.
    STRINGi9606.ENSP00000290295.

    Structurei

    Secondary structure

    1
    284
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi225 – 23713
    Helixi243 – 25210
    Helixi257 – 26913
    Turni270 – 2723

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2CRANMR-A217-273[»]
    ProteinModelPortaliQ92826.
    SMRiQ92826. Positions 216-273.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92826.

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG276440.
    HOGENOMiHOG000231176.
    HOVERGENiHBG106958.
    InParanoidiQ92826.
    OMAiHPPDGCA.
    OrthoDBiEOG7SJD53.
    PhylomeDBiQ92826.
    TreeFamiTF330813.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view]
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92826-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP    50
    LDLPGSAEPP KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC 100
    AQAATLAAYP AETPTAGEEY PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ 150
    TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS QMCCQGEQNP PGPFWKAAFA 200
    DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF ITKDKRRKIS 250
    AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP 284
    Length:284
    Mass (Da):30,676
    Last modified:July 19, 2004 - v2
    Checksum:i3EE5898449C33CFE
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti138 – 1392QP → HA(PubMed:8756292)Curated
    Sequence conflicti138 – 1392QP → HA(PubMed:9665387)Curated
    Sequence conflicti211 – 2111C → S in AAC50664. (PubMed:8756292)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti41 – 411T → M.1 Publication
    Corresponds to variant rs199799743 [ dbSNP | Ensembl ].
    VAR_031849

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57052 mRNA. Translation: AAC50664.1.
    U81599 mRNA. Translation: AAB39863.1.
    BT007410 mRNA. Translation: AAP36078.1.
    AK313266 mRNA. Translation: BAG36075.1.
    CH471109 Genomic DNA. Translation: EAW94714.1.
    BC007092 mRNA. Translation: AAH07092.1.
    BC070233 mRNA. Translation: AAH70233.1.
    CCDSiCCDS11536.1.
    RefSeqiNP_006352.2. NM_006361.5.
    UniGeneiHs.66731.

    Genome annotation databases

    EnsembliENST00000290295; ENSP00000290295; ENSG00000159184.
    GeneIDi10481.
    KEGGihsa:10481.
    UCSCiuc002ioa.3. human.

    Polymorphism databases

    DMDMi50403792.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U57052 mRNA. Translation: AAC50664.1 .
    U81599 mRNA. Translation: AAB39863.1 .
    BT007410 mRNA. Translation: AAP36078.1 .
    AK313266 mRNA. Translation: BAG36075.1 .
    CH471109 Genomic DNA. Translation: EAW94714.1 .
    BC007092 mRNA. Translation: AAH07092.1 .
    BC070233 mRNA. Translation: AAH70233.1 .
    CCDSi CCDS11536.1.
    RefSeqi NP_006352.2. NM_006361.5.
    UniGenei Hs.66731.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2CRA NMR - A 217-273 [» ]
    ProteinModelPortali Q92826.
    SMRi Q92826. Positions 216-273.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115744. 8 interactions.
    STRINGi 9606.ENSP00000290295.

    PTM databases

    PhosphoSitei Q92826.

    Polymorphism databases

    DMDMi 50403792.

    Proteomic databases

    MaxQBi Q92826.
    PaxDbi Q92826.
    PRIDEi Q92826.

    Protocols and materials databases

    DNASUi 10481.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000290295 ; ENSP00000290295 ; ENSG00000159184 .
    GeneIDi 10481.
    KEGGi hsa:10481.
    UCSCi uc002ioa.3. human.

    Organism-specific databases

    CTDi 10481.
    GeneCardsi GC17M046802.
    HGNCi HGNC:5112. HOXB13.
    HPAi CAB004438.
    HPA051885.
    MIMi 604607. gene.
    neXtProti NX_Q92826.
    Orphaneti 1331. Familial prostate cancer.
    PharmGKBi PA29388.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG276440.
    HOGENOMi HOG000231176.
    HOVERGENi HBG106958.
    InParanoidi Q92826.
    OMAi HPPDGCA.
    OrthoDBi EOG7SJD53.
    PhylomeDBi Q92826.
    TreeFami TF330813.

    Miscellaneous databases

    ChiTaRSi HOXB13. human.
    EvolutionaryTracei Q92826.
    GeneWikii HOXB13.
    GenomeRNAii 10481.
    NextBioi 39762.
    PROi Q92826.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92826.
    CleanExi HS_HOXB13.
    Genevestigatori Q92826.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR009057. Homeodomain-like.
    IPR022067. HoxA13_N.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    PF12284. HoxA13_N. 1 hit.
    [Graphical view ]
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity."
      Zeltser L.M., Desplan C., Heintz N.
      Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds."
      Stelnicki E.J., Arbeit J., Cass D.L., Saner C., Harrison M., Largman C.
      J. Invest. Dermatol. 111:57-63(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Prostate.
    7. "Solution structure of the homeobox domain of human homeo box B13."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2005) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 216-273.
    8. Cited for: VARIANT MET-41.

    Entry informationi

    Entry nameiHXB13_HUMAN
    AccessioniPrimary (citable) accession number: Q92826
    Secondary accession number(s): B2R878, Q96QM4, Q99810
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: July 19, 2004
    Last modified: October 1, 2014
    This is version 138 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    3. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    4. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    5. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    6. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3