Q92826 (HXB13_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-B13

Gene names

Name:

HOXB13

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	284 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.
Subcellular location	Nucleus.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Polymorphism
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from expression pattern PubMed 17972163. Source: UniProtKB epidermis development Traceable author statement Ref.2. Source: ProtInc epithelial cell maturation involved in prostate gland development Inferred from electronic annotation. Source: Compara prostate epithelial cord arborization involved in prostate glandular acinus morphogenesis Inferred from electronic annotation. Source: Compara regulation of growth Inferred from electronic annotation. Source: Compara response to testosterone stimulus Inferred from electronic annotation. Source: Compara response to wounding Traceable author statement Ref.2. Source: ProtInc transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	transcription factor complex Inferred from electronic annotation. Source: Compara
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Chain

1 – 284

284

Homeobox protein Hox-B13

PRO_0000200160

Regions

DNA binding

216 – 275

60

Homeobox

Natural variations

Natural variant

41

1

T → M. Ref.8

VAR_031849

Experimental info

Sequence conflict

138 – 139

2

QP → HA Ref.1

Sequence conflict

138 – 139

2

QP → HA Ref.2

Sequence conflict

211

1

C → S in AAC50664. Ref.1

Secondary structure

1

.

.

.

.

.

.

.

.

284

Helix Strand Turn

Details...

Helix

225 – 237

13

Helix

243 – 252

10

Helix

257 – 269

13

Turn

270 – 272

3

Sequences

	Sequence		Length	Mass (Da)
	Q92826 [UniParc]. Last modified July 19, 2004. Version 2. Checksum: 3EE5898449C33CFE	FASTA	284	30,676
	10 20 30 40 50 60 MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP LDLPGSAEPP 70 80 90 100 110 120 KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC AQAATLAAYP AETPTAGEEY 130 140 150 160 170 180 PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS 190 200 210 220 230 240 QMCCQGEQNP PGPFWKAAFA DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF 250 260 270 280 ITKDKRRKIS AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hoxb-13: a new Hox gene in a distant region of the HOXB cluster maintains colinearity." Zeltser L.M., Desplan C., Heintz N. Development 122:2475-2484(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Modulation of the human homeobox genes PRX-2 and HOXB13 in scarless fetal wounds." Stelnicki E.J., Arbeit J., Cass D.L., Saner C., Harrison M., Largman C. J. Invest. Dermatol. 111:57-63(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[3]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[4]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[7]	"Solution structure of the homeobox domain of human homeo box B13." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2005) to the PDB data bank Cited for: STRUCTURE BY NMR OF 216-273.
[8]	"Complete mutation analysis panel of the 39 human HOX genes." Kosaki K., Kosaki R., Suzuki T., Yoshihashi H., Takahashi T., Sasaki K., Tomita M., McGinnis W., Matsuo N. Teratology 65:50-62(2002) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANT MET-41.
+	Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U57052 mRNA. Translation: AAC50664.1.
U81599 mRNA. Translation: AAB39863.1.
BT007410 mRNA. Translation: AAP36078.1.
AK313266 mRNA. Translation: BAG36075.1.
CH471109 Genomic DNA. Translation: EAW94714.1.
BC007092 mRNA. Translation: AAH07092.1.
BC070233 mRNA. Translation: AAH70233.1.

IPI

IPI00294863.

RefSeq

NP_006352.2. NM_006361.5.

UniGene

Hs.66731.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
2CRA	NMR	-	A	217-273	[»]

ProteinModelPortal

Q92826.

ModBase

Search...

Protein-protein interaction databases

STRING

9606.ENSP00000290295.

PTM databases

PhosphoSite

Q92826.

Polymorphism databases

DMDM

50403792.

Proteomic databases

PaxDb

Q92826.

PRIDE

Q92826.

Protocols and materials databases

DNASU

10481.

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000290295; ENSP00000290295; ENSG00000159184.

GeneID

10481.

KEGG

hsa:10481.

UCSC

uc002ioa.3. human.

Organism-specific databases

CTD

10481.

GeneCards

GC17M046802.

HGNC

HGNC:5112. HOXB13.

HPA

CAB004438.

MIM

604607. gene.

neXtProt

NX_Q92826.

Orphanet

1331. Familial prostate cancer.

PharmGKB

PA29388.

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG276440.

HOGENOM

HOG000231176.

HOVERGEN

HBG106958.

InParanoid

Q92826.

OMA

EGCAFRR.

OrthoDB

EOG4J6RRD.

PhylomeDB

Q92826.

Enzyme and pathway databases

Pathway_Interaction_DB

ar_tf_pathway. Regulation of Androgen receptor activity.

Gene expression databases

Bgee

Q92826.

CleanEx

HS_HOXB13.

Genevestigator

Q92826.

GermOnline

ENSG00000159184. Homo sapiens.

Family and domain databases

Gene3D

1.10.10.60. 1 hit.

InterPro

IPR017970. Homeobox_CS.
IPR001356. Homeodomain.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]

Pfam

PF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]

SMART

SM00389. HOX. 1 hit.
[Graphical view]

SUPFAM

SSF46689. Homeodomain_like. 1 hit.

PROSITE

PS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

HOXB13. human.

EvolutionaryTrace

Q92826.

GenomeRNAi

10481.

NextBio

39762.

SOURCE

Search...

Entry information

Entry name

HXB13_HUMAN

Accession

Primary (citable) accession number: Q92826
Secondary accession number(s): B2R878, Q96QM4, Q99810

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	July 19, 2004
Last modified:	May 1, 2013
This is version 126 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.