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Protein

Homeobox protein Hox-B13

Gene

HOXB13

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi216 – 275HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159184-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-B13
Gene namesi
Name:HOXB13
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:5112. HOXB13.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

Prostate cancer (PC)5 Publications
Disease susceptibility is associated with variations affecting the gene represented in this entry.
Disease descriptionA malignancy originating in tissues of the prostate. Most prostate cancers are adenocarcinomas that develop in the acini of the prostatic ducts. Other rare histopathologic types of prostate cancer that occur in approximately 5% of patients include small cell carcinoma, mucinous carcinoma, prostatic ductal carcinoma, transitional cell carcinoma, squamous cell carcinoma, basal cell carcinoma, adenoid cystic carcinoma (basaloid), signet-ring cell carcinoma and neuroendocrine carcinoma.
See also OMIM:176807
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_07186684G → E in PC; rare variant associated with disease susceptibility. 5 PublicationsCorresponds to variant rs138213197dbSNPEnsembl.1

Keywords - Diseasei

Disease mutation

Organism-specific databases

DisGeNETi10481.
MalaCardsiHOXB13.
MIMi176807. phenotype.
OpenTargetsiENSG00000159184.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA29388.

Polymorphism and mutation databases

BioMutaiHOXB13.
DMDMi50403792.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002001601 – 284Homeobox protein Hox-B13Add BLAST284

Proteomic databases

MaxQBiQ92826.
PaxDbiQ92826.
PeptideAtlasiQ92826.
PRIDEiQ92826.

PTM databases

iPTMnetiQ92826.
PhosphoSitePlusiQ92826.

Expressioni

Gene expression databases

BgeeiENSG00000159184.
CleanExiHS_HOXB13.
GenevisibleiQ92826. HS.

Organism-specific databases

HPAiCAB004438.
HPA051885.
HPA062852.
HPA065019.

Interactioni

Protein-protein interaction databases

BioGridi115744. 15 interactors.
IntActiQ92826. 6 interactors.
STRINGi9606.ENSP00000290295.

Structurei

Secondary structure

1284
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi225 – 237Combined sources13
Helixi243 – 252Combined sources10
Helixi257 – 269Combined sources13
Turni270 – 272Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
ProteinModelPortaliQ92826.
SMRiQ92826.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92826.

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiQ92826.
OMAiHPPDGCA.
OrthoDBiEOG091G0E5Q.
PhylomeDBiQ92826.
TreeFamiTF330813.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92826-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPGNYATLD GAKDIEGLLG AGGGRNLVAH SPLTSHPAAP TLMPAVNYAP
60 70 80 90 100
LDLPGSAEPP KQCHPCPGVP QGTSPAPVPY GYFGGGYYSC RVSRSSLKPC
110 120 130 140 150
AQAATLAAYP AETPTAGEEY PSRPTEFAFY PGYPGTYQPM ASYLDVSVVQ
160 170 180 190 200
TLGAPGEPRH DSLLPVDSYQ SWALAGGWNS QMCCQGEQNP PGPFWKAAFA
210 220 230 240 250
DSSGQHPPDA CAFRRGRKKR IPYSKGQLRE LEREYAANKF ITKDKRRKIS
260 270 280
AATSLSERQI TIWFQNRRVK EKKVLAKVKN SATP
Length:284
Mass (Da):30,676
Last modified:July 19, 2004 - v2
Checksum:i3EE5898449C33CFE
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti138 – 139QP → HA (PubMed:8756292).Curated2
Sequence conflicti138 – 139QP → HA (PubMed:9665387).Curated2
Sequence conflicti211C → S in AAC50664 (PubMed:8756292).Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_03184941T → M.1 PublicationCorresponds to variant rs199799743dbSNPEnsembl.1
Natural variantiVAR_07186684G → E in PC; rare variant associated with disease susceptibility. 5 PublicationsCorresponds to variant rs138213197dbSNPEnsembl.1
Natural variantiVAR_07186788Y → D Found in prostate cancer samples; unknown pathological significance. 1 Publication1
Natural variantiVAR_071868144L → P Found in prostate cancer samples; unknown pathological significance. 1 Publication1
Natural variantiVAR_071869216G → C Found in prostate cancer samples; unknown pathological significance. 1 PublicationCorresponds to variant rs375917549dbSNPEnsembl.1
Natural variantiVAR_071870229R → G Found in prostate cancer samples; unknown pathological significance. 1 Publication1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA. Translation: AAC50664.1.
U81599 mRNA. Translation: AAB39863.1.
BT007410 mRNA. Translation: AAP36078.1.
AK313266 mRNA. Translation: BAG36075.1.
CH471109 Genomic DNA. Translation: EAW94714.1.
BC007092 mRNA. Translation: AAH07092.1.
BC070233 mRNA. Translation: AAH70233.1.
CCDSiCCDS11536.1.
RefSeqiNP_006352.2. NM_006361.5.
UniGeneiHs.66731.

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184.
GeneIDi10481.
KEGGihsa:10481.
UCSCiuc002ioa.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U57052 mRNA. Translation: AAC50664.1.
U81599 mRNA. Translation: AAB39863.1.
BT007410 mRNA. Translation: AAP36078.1.
AK313266 mRNA. Translation: BAG36075.1.
CH471109 Genomic DNA. Translation: EAW94714.1.
BC007092 mRNA. Translation: AAH07092.1.
BC070233 mRNA. Translation: AAH70233.1.
CCDSiCCDS11536.1.
RefSeqiNP_006352.2. NM_006361.5.
UniGeneiHs.66731.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CRANMR-A217-273[»]
ProteinModelPortaliQ92826.
SMRiQ92826.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115744. 15 interactors.
IntActiQ92826. 6 interactors.
STRINGi9606.ENSP00000290295.

PTM databases

iPTMnetiQ92826.
PhosphoSitePlusiQ92826.

Polymorphism and mutation databases

BioMutaiHOXB13.
DMDMi50403792.

Proteomic databases

MaxQBiQ92826.
PaxDbiQ92826.
PeptideAtlasiQ92826.
PRIDEiQ92826.

Protocols and materials databases

DNASUi10481.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000290295; ENSP00000290295; ENSG00000159184.
GeneIDi10481.
KEGGihsa:10481.
UCSCiuc002ioa.4. human.

Organism-specific databases

CTDi10481.
DisGeNETi10481.
GeneCardsiHOXB13.
HGNCiHGNC:5112. HOXB13.
HPAiCAB004438.
HPA051885.
HPA062852.
HPA065019.
MalaCardsiHOXB13.
MIMi176807. phenotype.
604607. gene.
neXtProtiNX_Q92826.
OpenTargetsiENSG00000159184.
Orphaneti1331. Familial prostate cancer.
PharmGKBiPA29388.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0487. Eukaryota.
ENOG4111FJP. LUCA.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231176.
HOVERGENiHBG106958.
InParanoidiQ92826.
OMAiHPPDGCA.
OrthoDBiEOG091G0E5Q.
PhylomeDBiQ92826.
TreeFamiTF330813.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000159184-MONOMER.

Miscellaneous databases

ChiTaRSiHOXB13. human.
EvolutionaryTraceiQ92826.
GeneWikiiHOXB13.
GenomeRNAii10481.
PROiQ92826.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000159184.
CleanExiHS_HOXB13.
GenevisibleiQ92826. HS.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR022067. HoxA13_N.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
PF12284. HoxA13_N. 1 hit.
[Graphical view]
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiHXB13_HUMAN
AccessioniPrimary (citable) accession number: Q92826
Secondary accession number(s): B2R878, Q96QM4, Q99810
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 19, 2004
Last modified: November 2, 2016
This is version 156 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  3. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  4. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  5. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  6. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.