SubmitCancel

Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q92824

- PCSK5_HUMAN

UniProt

Q92824 - PCSK5_HUMAN

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein
Proprotein convertase subtilisin/kexin type 5
Gene
PCSK5, PC5, PC6
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.3 Publications

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei114 – 1152Cleavage; by autolysis By similarity
Active sitei171 – 1711Charge relay system By similarity
Active sitei212 – 2121Charge relay system By similarity
Active sitei386 – 3861Charge relay system By similarity

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. peptide binding Source: BHF-UCL
  3. serine-type endopeptidase activity Source: BHF-UCL
Complete GO annotation...

GO - Biological processi

  1. anterior/posterior pattern specification Source: BHF-UCL
  2. cell-cell signaling Source: ProtInc
  3. cytokine biosynthetic process Source: BHF-UCL
  4. embryo implantation Source: BHF-UCL
  5. embryonic digestive tract development Source: BHF-UCL
  6. embryonic skeletal system development Source: BHF-UCL
  7. heart development Source: BHF-UCL
  8. kidney development Source: BHF-UCL
  9. limb morphogenesis Source: BHF-UCL
  10. nerve growth factor processing Source: Reactome
  11. neurotrophin TRK receptor signaling pathway Source: Reactome
  12. peptide biosynthetic process Source: BHF-UCL
  13. peptide hormone processing Source: BHF-UCL
  14. protein processing Source: BHF-UCL
  15. renin secretion into blood stream Source: BHF-UCL
  16. respiratory tube development Source: BHF-UCL
  17. signal peptide processing Source: HGNC
  18. viral life cycle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Pregnancy

Enzyme and pathway databases

ReactomeiREACT_11062. NGF processing.
SignaLinkiQ92824.

Protein family/group databases

MEROPSiS08.076.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
Alternative name(s):
Proprotein convertase 5
Short name:
PC5
Proprotein convertase 6
Short name:
PC6
Short name:
hPC6
Subtilisin/kexin-like protease PC5
Gene namesi
Name:PCSK5
Synonyms:PC5, PC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8747. PCSK5.

Subcellular locationi

Isoform PC6A : Secreted
Note: Secreted through the regulated secretory pathway By similarity.
Isoform PC6B : Endomembrane system; Single-pass type I membrane protein
Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes By similarity.

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini115 – 17431629Extracellular Reviewed prediction
Add
BLAST
Transmembranei1744 – 176421Helical; Reviewed prediction
Add
BLAST
Topological domaini1765 – 186096Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. Golgi apparatus Source: BHF-UCL
  2. Golgi lumen Source: Reactome
  3. extracellular space Source: BHF-UCL
  4. integral component of membrane Source: UniProtKB-KW
  5. secretory granule Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232 By similarity
Add
BLAST
Propeptidei33 – 11482 By similarity
PRO_0000027102Add
BLAST
Chaini115 – 18601746Proprotein convertase subtilisin/kexin type 5
PRO_0000027103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi225 – 2251N-linked (GlcNAc...) Reviewed prediction
Glycosylationi381 – 3811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi665 – 6651N-linked (GlcNAc...) Reviewed prediction
Glycosylationi752 – 7521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi802 – 8021N-linked (GlcNAc...) Reviewed prediction
Glycosylationi852 – 8521N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1014 – 10141N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1191 – 11911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1290 – 12901N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1497 – 14971N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1685 – 16851N-linked (GlcNAc...) Reviewed prediction
Glycosylationi1707 – 17071N-linked (GlcNAc...) Reviewed prediction

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ92824.
PRIDEiQ92824.

PTM databases

PhosphoSiteiQ92824.

Miscellaneous databases

PMAP-CutDBQ92824.

Expressioni

Tissue specificityi

Expressed in T-lymphocytes.

Gene expression databases

ArrayExpressiQ92824.
BgeeiQ92824.
CleanExiHS_PCSK5.
GenevestigatoriQ92824.

Organism-specific databases

HPAiHPA031072.

Interactioni

Protein-protein interaction databases

BioGridi111152. 7 interactions.
IntActiQ92824. 4 interactions.
MINTiMINT-1474189.
STRINGi9606.ENSP00000365943.

Structurei

3D structure databases

ProteinModelPortaliQ92824.
SMRiQ92824. Positions 128-599.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini462 – 600139Homo B/P
Add
BLAST
Domaini869 – 91345PLAC
Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni115 – 454340Catalytic
Add
BLAST
Regioni636 – 17271092CRM (Cys-rich motif)
Add
BLAST
Regioni1807 – 182620AC 1 By similarity
Add
BLAST
Regioni1838 – 186023AC 2 By similarity
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi519 – 5213Cell attachment site Reviewed prediction

Domaini

The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 By similarity.

Sequence similaritiesi

Belongs to the peptidase S8 family.
Contains 1 homo B/P domain.
Contains 1 PLAC domain.

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4935.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
KOiK08654.
OMAiLHEGRCY.
PhylomeDBiQ92824.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00181. EGF. 1 hit.
SM00261. FU. 22 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 7 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform PC6B (identifier: Q92824-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA     50
NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV 100
EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM 150
NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP 200
MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT 250
DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR 300
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE 350
CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL 400
EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE 450
AMVMEAEKWT TVPRQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNR 500
HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK 550
NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV 600
QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP 650
DHCNDCLHYY YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH 700
GDQCMSCKYG YFLNEETNSC VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF 750
HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ DCQPCHRFCA TCAGAGADGC 800
INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI SCLTCNGPGF 850
KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ 900
EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC 950
TSCGADNYGR EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV 1000
CTRCMKGYFI APTNHTCQKL ECGQGEVQDP DYEECVPCEE GCLGCSLDDP 1050
GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV ECKACDSNCG SCDQNGCYWC 1100
EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG PGHDECSSCQ 1150
EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC 1200
PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ 1250
PGHPLFLHEG RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG 1300
HVLHHGVCQE NCPERHVAVK GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD 1350
DMCHQSCPRG FYADSRHCVP CHKDCLECSG PKADDCELCL ESSWVLYDGL 1400
CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG LIMNPRGSCM 1450
ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC 1500
VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL 1550
LQCREGYYAD NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC 1600
HRSCPDHYYV EQSTQTCERC HPTCDQCKGK GALNCLSCVW SYHLMGGICT 1650
SDCLVGEYRV GEGEKFNCEK CHESCMECKG PGAKNCTLCP ANLVLHMDDS 1700
HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH FKTALFITSS 1750
MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST 1800
SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE 1850
YDDESYSYYQ 1860
Length:1,860
Mass (Da):206,942
Last modified:November 16, 2011 - v4
Checksum:i96B3E7C8215BCC85
GO
Isoform PC6A (identifier: Q92824-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
     914-1860: Missing.

Show »
Length:913
Mass (Da):101,649
Checksum:i7A2E63EFC49104BC
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei876 – 91338GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A.
VSP_042017Add
BLAST
Alternative sequencei914 – 1860947Missing in isoform PC6A.
VSP_042018Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21G → D in AAC50643. 1 Publication
Sequence conflicti4 – 41G → E in AAC50643. 1 Publication
Sequence conflicti118 – 1181F → S in AAC50643. 1 Publication
Sequence conflicti121 – 1211A → V in AAC50643. 1 Publication
Sequence conflicti511 – 5111R → A in AAA91807. 1 Publication
Sequence conflicti601 – 6011Q → R in AAC50643. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56387 mRNA. Translation: AAC50643.2.
AL834522 mRNA. Translation: CAD39178.1.
AL359253, AL353607 Genomic DNA. Translation: CAH73743.1.
AL353607, AL359253 Genomic DNA. Translation: CAI41233.1.
AL391868 Genomic DNA. No translation available.
AL589653 Genomic DNA. No translation available.
CH471089 Genomic DNA. Translation: EAW62575.1.
BC012064 mRNA. Translation: AAH12064.1.
U49114 mRNA. Translation: AAA91807.1.
AK122718 mRNA. No translation available.
CCDSiCCDS55320.1. [Q92824-1]
CCDS6652.1. [Q92824-2]
PIRiG02428.
JC6148.
RefSeqiNP_001177411.1. NM_001190482.1. [Q92824-1]
NP_006191.2. NM_006200.5. [Q92824-2]
UniGeneiHs.368542.

Genome annotation databases

EnsembliENST00000376752; ENSP00000365943; ENSG00000099139. [Q92824-2]
ENST00000545128; ENSP00000446280; ENSG00000099139. [Q92824-1]
GeneIDi5125.
KEGGihsa:5125.
UCSCiuc004ajz.3. human. [Q92824-2]
uc004akc.2. human. [Q92824-1]

Polymorphism databases

DMDMi357529585.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U56387 mRNA. Translation: AAC50643.2 .
AL834522 mRNA. Translation: CAD39178.1 .
AL359253 , AL353607 Genomic DNA. Translation: CAH73743.1 .
AL353607 , AL359253 Genomic DNA. Translation: CAI41233.1 .
AL391868 Genomic DNA. No translation available.
AL589653 Genomic DNA. No translation available.
CH471089 Genomic DNA. Translation: EAW62575.1 .
BC012064 mRNA. Translation: AAH12064.1 .
U49114 mRNA. Translation: AAA91807.1 .
AK122718 mRNA. No translation available.
CCDSi CCDS55320.1. [Q92824-1 ]
CCDS6652.1. [Q92824-2 ]
PIRi G02428.
JC6148.
RefSeqi NP_001177411.1. NM_001190482.1. [Q92824-1 ]
NP_006191.2. NM_006200.5. [Q92824-2 ]
UniGenei Hs.368542.

3D structure databases

ProteinModelPortali Q92824.
SMRi Q92824. Positions 128-599.
ModBasei Search...

Protein-protein interaction databases

BioGridi 111152. 7 interactions.
IntActi Q92824. 4 interactions.
MINTi MINT-1474189.
STRINGi 9606.ENSP00000365943.

Chemistry

BindingDBi Q92824.
ChEMBLi CHEMBL2826.

Protein family/group databases

MEROPSi S08.076.

PTM databases

PhosphoSitei Q92824.

Polymorphism databases

DMDMi 357529585.

Proteomic databases

PaxDbi Q92824.
PRIDEi Q92824.

Protocols and materials databases

DNASUi 5125.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376752 ; ENSP00000365943 ; ENSG00000099139 . [Q92824-2 ]
ENST00000545128 ; ENSP00000446280 ; ENSG00000099139 . [Q92824-1 ]
GeneIDi 5125.
KEGGi hsa:5125.
UCSCi uc004ajz.3. human. [Q92824-2 ]
uc004akc.2. human. [Q92824-1 ]

Organism-specific databases

CTDi 5125.
GeneCardsi GC09P078505.
HGNCi HGNC:8747. PCSK5.
HPAi HPA031072.
MIMi 600488. gene.
neXtProti NX_Q92824.
PharmGKBi PA33093.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4935.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
KOi K08654.
OMAi LHEGRCY.
PhylomeDBi Q92824.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_11062. NGF processing.
SignaLinki Q92824.

Miscellaneous databases

GeneWikii PCSK5.
GenomeRNAii 5125.
NextBioi 19754.
PMAP-CutDB Q92824.
PROi Q92824.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92824.
Bgeei Q92824.
CleanExi HS_PCSK5.
Genevestigatori Q92824.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SMARTi SM00181. EGF. 1 hit.
SM00261. FU. 22 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 7 hits.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes."
    Miranda L., Wolf J., Pichuantes S., Duke R., Franzusoff A.
    Proc. Natl. Acad. Sci. U.S.A. 93:7695-7700(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC6A), ALTERNATIVE SPLICING.
    Tissue: T-cell.
  2. Franzusoff A., Miranda L., Wolf J., Pichuantes S., Lu Y., Duke R.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
    Tissue: Lymph node.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
    Tissue: Kidney.
  7. Reudelhuber T.L.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-913 (ISOFORM PC6A).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-1860 (ISOFORM PC6B).
    Tissue: Tongue.
  9. "Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment."
    Kilpatrick L.M., Stephens A.N., Hardman B.M., Salamonsen L.A., Li Y., Stanton P.G., Nie G.
    J. Proteome Res. 8:4983-4992(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
  10. "Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
    Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G.
    Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
  11. "Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6."
    Paule S., Aljofan M., Simon C., Rombauts L.J., Nie G.
    Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPCSK5_HUMAN
AccessioniPrimary (citable) accession number: Q92824
Secondary accession number(s): F5H2G7, Q13527, Q96EP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 16, 2011
Last modified: September 3, 2014
This is version 147 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi