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Q92824

- PCSK5_HUMAN

UniProt

Q92824 - PCSK5_HUMAN

Protein

Proprotein convertase subtilisin/kexin type 5

Gene

PCSK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 148 (01 Oct 2014)
      Sequence version 4 (16 Nov 2011)
      Previous versions | rss
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    Functioni

    Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.3 Publications

    Catalytic activityi

    Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei114 – 1152Cleavage; by autolysisBy similarity
    Active sitei171 – 1711Charge relay systemBy similarity
    Active sitei212 – 2121Charge relay systemBy similarity
    Active sitei386 – 3861Charge relay systemBy similarity

    GO - Molecular functioni

    1. peptidase activity Source: MGI
    2. peptide binding Source: BHF-UCL
    3. serine-type endopeptidase activity Source: BHF-UCL

    GO - Biological processi

    1. anterior/posterior pattern specification Source: BHF-UCL
    2. cell-cell signaling Source: ProtInc
    3. cytokine biosynthetic process Source: BHF-UCL
    4. embryo implantation Source: BHF-UCL
    5. embryonic digestive tract development Source: BHF-UCL
    6. embryonic skeletal system development Source: BHF-UCL
    7. heart development Source: BHF-UCL
    8. kidney development Source: BHF-UCL
    9. limb morphogenesis Source: BHF-UCL
    10. nerve growth factor processing Source: Reactome
    11. neurotrophin TRK receptor signaling pathway Source: Reactome
    12. peptide biosynthetic process Source: BHF-UCL
    13. peptide hormone processing Source: BHF-UCL
    14. protein processing Source: BHF-UCL
    15. renin secretion into blood stream Source: BHF-UCL
    16. respiratory tube development Source: BHF-UCL
    17. signal peptide processing Source: HGNC
    18. viral life cycle Source: BHF-UCL

    Keywords - Molecular functioni

    Hydrolase, Protease, Serine protease

    Keywords - Biological processi

    Pregnancy

    Enzyme and pathway databases

    ReactomeiREACT_11062. NGF processing.
    SignaLinkiQ92824.

    Protein family/group databases

    MEROPSiS08.076.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
    Alternative name(s):
    Proprotein convertase 5
    Short name:
    PC5
    Proprotein convertase 6
    Short name:
    PC6
    Short name:
    hPC6
    Subtilisin/kexin-like protease PC5
    Gene namesi
    Name:PCSK5
    Synonyms:PC5, PC6
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:8747. PCSK5.

    Subcellular locationi

    Isoform PC6A : Secreted
    Note: Secreted through the regulated secretory pathway.By similarity
    Isoform PC6B : Endomembrane system; Single-pass type I membrane protein
    Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.By similarity

    GO - Cellular componenti

    1. extracellular space Source: BHF-UCL
    2. Golgi apparatus Source: BHF-UCL
    3. Golgi lumen Source: Reactome
    4. integral component of membrane Source: UniProtKB-KW
    5. secretory granule Source: BHF-UCL

    Keywords - Cellular componenti

    Membrane, Secreted

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33093.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3232By similarityAdd
    BLAST
    Propeptidei33 – 11482By similarityPRO_0000027102Add
    BLAST
    Chaini115 – 18601746Proprotein convertase subtilisin/kexin type 5PRO_0000027103Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi852 – 8521N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1014 – 10141N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1191 – 11911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1290 – 12901N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1497 – 14971N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1685 – 16851N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1707 – 17071N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Cleavage on pair of basic residues, Glycoprotein, Zymogen

    Proteomic databases

    PaxDbiQ92824.
    PRIDEiQ92824.

    PTM databases

    PhosphoSiteiQ92824.

    Miscellaneous databases

    PMAP-CutDBQ92824.

    Expressioni

    Tissue specificityi

    Expressed in T-lymphocytes.

    Gene expression databases

    ArrayExpressiQ92824.
    BgeeiQ92824.
    CleanExiHS_PCSK5.
    GenevestigatoriQ92824.

    Organism-specific databases

    HPAiHPA031072.

    Interactioni

    Protein-protein interaction databases

    BioGridi111152. 7 interactions.
    IntActiQ92824. 4 interactions.
    MINTiMINT-1474189.
    STRINGi9606.ENSP00000365943.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92824.
    SMRiQ92824. Positions 128-599.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini115 – 17431629ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1765 – 186096CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1744 – 176421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini166 – 453288Peptidase S8Add
    BLAST
    Repeati630 – 68051FU 1Add
    BLAST
    Repeati683 – 73048FU 2Add
    BLAST
    Repeati734 – 77744FU 3Add
    BLAST
    Repeati779 – 82446FU 4Add
    BLAST
    Repeati832 – 87948FU 5Add
    BLAST
    Domaini869 – 91345PLACAdd
    BLAST
    Repeati882 – 92746FU 6Add
    BLAST
    Repeati929 – 97951FU 7Add
    BLAST
    Repeati982 – 102847FU 8Add
    BLAST
    Repeati1032 – 107746FU 9Add
    BLAST
    Repeati1079 – 112143FU 10Add
    BLAST
    Repeati1125 – 116844FU 11Add
    BLAST
    Repeati1177 – 122145FU 12Add
    BLAST
    Repeati1225 – 127248FU 13Add
    BLAST
    Repeati1274 – 131845FU 14Add
    BLAST
    Repeati1320 – 136344FU 15Add
    BLAST
    Repeati1365 – 141147FU 16Add
    BLAST
    Repeati1415 – 146147FU 17Add
    BLAST
    Repeati1465 – 151046FU 18Add
    BLAST
    Repeati1514 – 155946FU 19Add
    BLAST
    Repeati1563 – 161048FU 20Add
    BLAST
    Repeati1614 – 165946FU 21Add
    BLAST
    Repeati1665 – 171248FU 22Add
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni636 – 17271092CRM (Cys-rich motif)Add
    BLAST
    Regioni1807 – 182620AC 1By similarityAdd
    BLAST
    Regioni1838 – 186023AC 2By similarityAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi519 – 5213Cell attachment siteSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1812 – 185342Asp-richAdd
    BLAST

    Domaini

    The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
    AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 By similarity.By similarity

    Sequence similaritiesi

    Belongs to the peptidase S8 family.Curated
    Contains 22 FU (furin-like) repeats.Curated
    Contains 1 peptidase S8 domain.Curated
    Contains 1 PLAC domain.Curated

    Keywords - Domaini

    Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG4935.
    HOGENOMiHOG000192536.
    HOVERGENiHBG008705.
    KOiK08654.
    OMAiLHEGRCY.
    PhylomeDBiQ92824.
    TreeFamiTF314277.

    Family and domain databases

    Gene3Di2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProiIPR000742. EG-like_dom.
    IPR006212. Furin_repeat.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view]
    PANTHERiPTHR10795. PTHR10795. 1 hit.
    PfamiPF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view]
    PRINTSiPR00723. SUBTILISIN.
    SMARTiSM00181. EGF. 1 hit.
    SM00261. FU. 22 hits.
    [Graphical view]
    SUPFAMiSSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    SSF57184. SSF57184. 7 hits.
    PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform PC6B (identifier: Q92824-1) [UniParc]FASTAAdd to Basket

    Also known as: Long

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA     50
    NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV 100
    EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM 150
    NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP 200
    MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT 250
    DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR 300
    RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE 350
    CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL 400
    EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE 450
    AMVMEAEKWT TVPRQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNR 500
    HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK 550
    NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV 600
    QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP 650
    DHCNDCLHYY YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH 700
    GDQCMSCKYG YFLNEETNSC VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF 750
    HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ DCQPCHRFCA TCAGAGADGC 800
    INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI SCLTCNGPGF 850
    KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ 900
    EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC 950
    TSCGADNYGR EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV 1000
    CTRCMKGYFI APTNHTCQKL ECGQGEVQDP DYEECVPCEE GCLGCSLDDP 1050
    GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV ECKACDSNCG SCDQNGCYWC 1100
    EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG PGHDECSSCQ 1150
    EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC 1200
    PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ 1250
    PGHPLFLHEG RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG 1300
    HVLHHGVCQE NCPERHVAVK GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD 1350
    DMCHQSCPRG FYADSRHCVP CHKDCLECSG PKADDCELCL ESSWVLYDGL 1400
    CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG LIMNPRGSCM 1450
    ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC 1500
    VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL 1550
    LQCREGYYAD NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC 1600
    HRSCPDHYYV EQSTQTCERC HPTCDQCKGK GALNCLSCVW SYHLMGGICT 1650
    SDCLVGEYRV GEGEKFNCEK CHESCMECKG PGAKNCTLCP ANLVLHMDDS 1700
    HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH FKTALFITSS 1750
    MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST 1800
    SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE 1850
    YDDESYSYYQ 1860
    Length:1,860
    Mass (Da):206,942
    Last modified:November 16, 2011 - v4
    Checksum:i96B3E7C8215BCC85
    GO
    Isoform PC6A (identifier: Q92824-2) [UniParc]FASTAAdd to Basket

    Also known as: Short

    The sequence of this isoform differs from the canonical sequence as follows:
         876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
         914-1860: Missing.

    Show »
    Length:913
    Mass (Da):101,649
    Checksum:i7A2E63EFC49104BC
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti2 – 21G → D in AAC50643. (PubMed:8755538)Curated
    Sequence conflicti4 – 41G → E in AAC50643. (PubMed:8755538)Curated
    Sequence conflicti118 – 1181F → S in AAC50643. (PubMed:8755538)Curated
    Sequence conflicti121 – 1211A → V in AAC50643. (PubMed:8755538)Curated
    Sequence conflicti511 – 5111R → A in AAA91807. 1 PublicationCurated
    Sequence conflicti601 – 6011Q → R in AAC50643. (PubMed:8755538)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei876 – 91338GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A. 4 PublicationsVSP_042017Add
    BLAST
    Alternative sequencei914 – 1860947Missing in isoform PC6A. 4 PublicationsVSP_042018Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56387 mRNA. Translation: AAC50643.2.
    AL834522 mRNA. Translation: CAD39178.1.
    AL359253, AL353607 Genomic DNA. Translation: CAH73743.1.
    AL353607, AL359253 Genomic DNA. Translation: CAI41233.1.
    AL391868 Genomic DNA. No translation available.
    AL589653 Genomic DNA. No translation available.
    CH471089 Genomic DNA. Translation: EAW62575.1.
    BC012064 mRNA. Translation: AAH12064.1.
    U49114 mRNA. Translation: AAA91807.1.
    AK122718 mRNA. No translation available.
    CCDSiCCDS55320.1. [Q92824-1]
    CCDS6652.1. [Q92824-2]
    PIRiG02428.
    JC6148.
    RefSeqiNP_001177411.1. NM_001190482.1. [Q92824-1]
    NP_006191.2. NM_006200.5. [Q92824-2]
    UniGeneiHs.368542.

    Genome annotation databases

    EnsembliENST00000376752; ENSP00000365943; ENSG00000099139. [Q92824-2]
    ENST00000545128; ENSP00000446280; ENSG00000099139. [Q92824-1]
    GeneIDi5125.
    KEGGihsa:5125.
    UCSCiuc004ajz.3. human. [Q92824-2]
    uc004akc.2. human. [Q92824-1]

    Polymorphism databases

    DMDMi357529585.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U56387 mRNA. Translation: AAC50643.2 .
    AL834522 mRNA. Translation: CAD39178.1 .
    AL359253 , AL353607 Genomic DNA. Translation: CAH73743.1 .
    AL353607 , AL359253 Genomic DNA. Translation: CAI41233.1 .
    AL391868 Genomic DNA. No translation available.
    AL589653 Genomic DNA. No translation available.
    CH471089 Genomic DNA. Translation: EAW62575.1 .
    BC012064 mRNA. Translation: AAH12064.1 .
    U49114 mRNA. Translation: AAA91807.1 .
    AK122718 mRNA. No translation available.
    CCDSi CCDS55320.1. [Q92824-1 ]
    CCDS6652.1. [Q92824-2 ]
    PIRi G02428.
    JC6148.
    RefSeqi NP_001177411.1. NM_001190482.1. [Q92824-1 ]
    NP_006191.2. NM_006200.5. [Q92824-2 ]
    UniGenei Hs.368542.

    3D structure databases

    ProteinModelPortali Q92824.
    SMRi Q92824. Positions 128-599.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111152. 7 interactions.
    IntActi Q92824. 4 interactions.
    MINTi MINT-1474189.
    STRINGi 9606.ENSP00000365943.

    Chemistry

    BindingDBi Q92824.
    ChEMBLi CHEMBL2826.

    Protein family/group databases

    MEROPSi S08.076.

    PTM databases

    PhosphoSitei Q92824.

    Polymorphism databases

    DMDMi 357529585.

    Proteomic databases

    PaxDbi Q92824.
    PRIDEi Q92824.

    Protocols and materials databases

    DNASUi 5125.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376752 ; ENSP00000365943 ; ENSG00000099139 . [Q92824-2 ]
    ENST00000545128 ; ENSP00000446280 ; ENSG00000099139 . [Q92824-1 ]
    GeneIDi 5125.
    KEGGi hsa:5125.
    UCSCi uc004ajz.3. human. [Q92824-2 ]
    uc004akc.2. human. [Q92824-1 ]

    Organism-specific databases

    CTDi 5125.
    GeneCardsi GC09P078505.
    HGNCi HGNC:8747. PCSK5.
    HPAi HPA031072.
    MIMi 600488. gene.
    neXtProti NX_Q92824.
    PharmGKBi PA33093.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG4935.
    HOGENOMi HOG000192536.
    HOVERGENi HBG008705.
    KOi K08654.
    OMAi LHEGRCY.
    PhylomeDBi Q92824.
    TreeFami TF314277.

    Enzyme and pathway databases

    Reactomei REACT_11062. NGF processing.
    SignaLinki Q92824.

    Miscellaneous databases

    GeneWikii PCSK5.
    GenomeRNAii 5125.
    NextBioi 19754.
    PMAP-CutDB Q92824.
    PROi Q92824.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92824.
    Bgeei Q92824.
    CleanExi HS_PCSK5.
    Genevestigatori Q92824.

    Family and domain databases

    Gene3Di 2.60.120.260. 1 hit.
    3.40.50.200. 1 hit.
    InterProi IPR000742. EG-like_dom.
    IPR006212. Furin_repeat.
    IPR008979. Galactose-bd-like.
    IPR009030. Growth_fac_rcpt_N_dom.
    IPR000209. Peptidase_S8/S53_dom.
    IPR023827. Peptidase_S8_Asp-AS.
    IPR022398. Peptidase_S8_His-AS.
    IPR023828. Peptidase_S8_Ser-AS.
    IPR015500. Peptidase_S8_subtilisin-rel.
    IPR009020. Prot_inh_propept.
    IPR002884. PrprotnconvertsP.
    [Graphical view ]
    PANTHERi PTHR10795. PTHR10795. 1 hit.
    Pfami PF01483. P_proprotein. 1 hit.
    PF00082. Peptidase_S8. 1 hit.
    [Graphical view ]
    PRINTSi PR00723. SUBTILISIN.
    SMARTi SM00181. EGF. 1 hit.
    SM00261. FU. 22 hits.
    [Graphical view ]
    SUPFAMi SSF49785. SSF49785. 1 hit.
    SSF52743. SSF52743. 1 hit.
    SSF54897. SSF54897. 1 hit.
    SSF57184. SSF57184. 7 hits.
    PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
    PS00137. SUBTILASE_HIS. 1 hit.
    PS00138. SUBTILASE_SER. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes."
      Miranda L., Wolf J., Pichuantes S., Duke R., Franzusoff A.
      Proc. Natl. Acad. Sci. U.S.A. 93:7695-7700(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC6A), ALTERNATIVE SPLICING.
      Tissue: T-cell.
    2. Franzusoff A., Miranda L., Wolf J., Pichuantes S., Lu Y., Duke R.
      Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: SEQUENCE REVISION.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
      Tissue: Lymph node.
    4. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
      Tissue: Kidney.
    7. Reudelhuber T.L.
      Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-913 (ISOFORM PC6A).
    8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-1860 (ISOFORM PC6B).
      Tissue: Tongue.
    9. "Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment."
      Kilpatrick L.M., Stephens A.N., Hardman B.M., Salamonsen L.A., Li Y., Stanton P.G., Nie G.
      J. Proteome Res. 8:4983-4992(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
    10. "Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
      Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G.
      Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
    11. "Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6."
      Paule S., Aljofan M., Simon C., Rombauts L.J., Nie G.
      Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION.

    Entry informationi

    Entry nameiPCSK5_HUMAN
    AccessioniPrimary (citable) accession number: Q92824
    Secondary accession number(s): F5H2G7, Q13527, Q96EP4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: November 16, 2011
    Last modified: October 1, 2014
    This is version 148 of the entry and version 4 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. Peptidase families
      Classification of peptidase families and list of entries
    4. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3