Q92824 (PCSK5_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Proprotein convertase subtilisin/kexin type 5
EC=3.4.21.-

Alternative name(s):
Proprotein convertase 5
Short name=PC5
Proprotein convertase 6
Short name=PC6
Short name=hPC6
Subtilisin/kexin-like protease PC5

Gene names

Name:	PCSK5
Synonyms:	PC5, PC6

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1860 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins. Ref.9 Ref.10 Ref.11
Catalytic activity	Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.
Subcellular location	Isoform PC6A: Secreted. Note: Secreted through the regulated secretory pathway By similarity. Isoform PC6B: Endomembrane system; Single-pass type I membrane protein. Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes By similarity.
Tissue specificity	Expressed in T-lymphocytes.
Domain	The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum. AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 By similarity.
Sequence similarities	Belongs to the peptidase S8 family. Contains 1 homo B/P domain. Contains 1 PLAC domain.

Ontologies

Keywords
Biological process	Pregnancy
Cellular component	Membrane Secreted
Coding sequence diversity	Alternative splicing
Domain	Repeat Signal Transmembrane Transmembrane helix
Molecular function	Hydrolase Protease Serine protease
PTM	Cleavage on pair of basic residues Glycoprotein Zymogen
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anterior/posterior pattern specification Inferred from mutant phenotype PubMed 18519639. Source: BHF-UCL cell-cell signaling Traceable author statement PubMed 8901832. Source: ProtInc cytokine biosynthetic process Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL embryo implantation Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL embryonic digestive tract development Inferred from mutant phenotype PubMed 18519639. Source: BHF-UCL embryonic skeletal system development Inferred from mutant phenotype PubMed 18519639. Source: BHF-UCL heart development Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL kidney development Inferred from mutant phenotype PubMed 18519639. Source: BHF-UCL limb morphogenesis Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL nerve growth factor processing Traceable author statement. Source: Reactome nerve growth factor receptor signaling pathway Traceable author statement. Source: Reactome peptide biosynthetic process Inferred from direct assay PubMed 8901832. Source: BHF-UCL proteolysis Inferred from electronic annotation. Source: UniProtKB-KW renin secretion into blood stream Inferred from expression pattern PubMed 8901832. Source: BHF-UCL respiratory tube development Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL signal peptide processing Inferred from direct assay PubMed 16912035. Source: HGNC viral assembly, maturation, egress, and release Inferred from expression pattern PubMed 8940009. Source: BHF-UCL
Cellular_component	Golgi lumen Traceable author statement. Source: Reactome endomembrane system Inferred from electronic annotation. Source: UniProtKB-SubCell extracellular space Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL integral to membrane Inferred from electronic annotation. Source: UniProtKB-KW secretory granule Inferred from sequence or structural similarity. Source: BHF-UCL
Molecular_function	peptide binding Inferred from sequence or structural similarity PubMed 8940009. Source: BHF-UCL serine-type endopeptidase activity Inferred from direct assay PubMed 8901832. Source: BHF-UCL
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform PC6B (identifier: Q92824-1)

Also known as: Long;

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform PC6A (identifier: Q92824-2)

Also known as: Short;

The sequence of this isoform differs from the canonical sequence as follows:
     876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
     914-1860: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Signal peptide	1 – 32	32	By similarity
	Propeptide	33 – 114	82	By similarity		PRO_0000027102
	Chain	115 – 1860	1746	Proprotein convertase subtilisin/kexin type 5		PRO_0000027103
Regions
	Topological domain	115 – 1743	1629	Extracellular Potential
	Transmembrane	1744 – 1764	21	Helical; Potential
	Topological domain	1765 – 1860	96	Cytoplasmic Potential
	Domain	462 – 600	139	Homo B/P
	Domain	869 – 913	45	PLAC
	Region	115 – 454	340	Catalytic
	Region	636 – 1727	1092	CRM (Cys-rich motif)
	Region	1807 – 1826	20	AC 1 By similarity
	Region	1838 – 1860	23	AC 2 By similarity
	Motif	519 – 521	3	Cell attachment site Potential
Sites
	Active site	171	1	Charge relay system By similarity
	Active site	212	1	Charge relay system By similarity
	Active site	386	1	Charge relay system By similarity
	Site	114 – 115	2	Cleavage; by autolysis By similarity
Amino acid modifications
	Glycosylation	225	1	N-linked (GlcNAc...) Potential
	Glycosylation	381	1	N-linked (GlcNAc...) Potential
	Glycosylation	665	1	N-linked (GlcNAc...) Potential
	Glycosylation	752	1	N-linked (GlcNAc...) Potential
	Glycosylation	802	1	N-linked (GlcNAc...) Potential
	Glycosylation	852	1	N-linked (GlcNAc...) Potential
	Glycosylation	1014	1	N-linked (GlcNAc...) Potential
	Glycosylation	1191	1	N-linked (GlcNAc...) Potential
	Glycosylation	1290	1	N-linked (GlcNAc...) Potential
	Glycosylation	1497	1	N-linked (GlcNAc...) Potential
	Glycosylation	1685	1	N-linked (GlcNAc...) Potential
	Glycosylation	1707	1	N-linked (GlcNAc...) Potential
Natural variations
	Alternative sequence	876 – 913	38	GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A.		VSP_042017
	Alternative sequence	914 – 1860	947	Missing in isoform PC6A.		VSP_042018
Experimental info
	Sequence conflict	2	1	G → D in AAC50643. Ref.1
	Sequence conflict	4	1	G → E in AAC50643. Ref.1
	Sequence conflict	118	1	F → S in AAC50643. Ref.1
	Sequence conflict	121	1	A → V in AAC50643. Ref.1
	Sequence conflict	511	1	R → A in AAA91807. Ref.7
	Sequence conflict	601	1	Q → R in AAC50643. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform PC6B (Long) [UniParc]. Last modified November 16, 2011. Version 4. Checksum: 96B3E7C8215BCC85	FASTA	1,860	206,942
	10 20 30 40 50 60 MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA NRIASKYGFI 70 80 90 100 110 120 NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV EWIQQQVVKK RTKRDYDFSR 130 140 150 160 170 180 AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD 190 200 210 220 230 240 LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG 250 260 270 280 290 300 GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR 310 320 330 340 350 360 RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE CSSTLATTYS 370 380 390 400 410 420 SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL EANPFLTWRD VQHVIVRTSR 430 440 450 460 470 480 AGHLNANDWK TNAAGFKVSH LYGFGLMDAE AMVMEAEKWT TVPRQHVCVE STDRQIKTIR 490 500 510 520 530 540 PNSAVRSIYK ASGCSDNPNR HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR 550 560 570 580 590 600 LFDHSMEGFK NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV 610 620 630 640 650 660 QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP DHCNDCLHYY 670 680 690 700 710 720 YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH GDQCMSCKYG YFLNEETNSC 730 740 750 760 770 780 VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ 790 800 810 820 830 840 DCQPCHRFCA TCAGAGADGC INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI 850 860 870 880 890 900 SCLTCNGPGF KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ 910 920 930 940 950 960 EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC TSCGADNYGR 970 980 990 1000 1010 1020 EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV CTRCMKGYFI APTNHTCQKL 1030 1040 1050 1060 1070 1080 ECGQGEVQDP DYEECVPCEE GCLGCSLDDP GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV 1090 1100 1110 1120 1130 1140 ECKACDSNCG SCDQNGCYWC EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG 1150 1160 1170 1180 1190 1200 PGHDECSSCQ EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC 1210 1220 1230 1240 1250 1260 PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ PGHPLFLHEG 1270 1280 1290 1300 1310 1320 RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG HVLHHGVCQE NCPERHVAVK 1330 1340 1350 1360 1370 1380 GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD DMCHQSCPRG FYADSRHCVP CHKDCLECSG 1390 1400 1410 1420 1430 1440 PKADDCELCL ESSWVLYDGL CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG 1450 1460 1470 1480 1490 1500 LIMNPRGSCM ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC 1510 1520 1530 1540 1550 1560 VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL LQCREGYYAD 1570 1580 1590 1600 1610 1620 NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC HRSCPDHYYV EQSTQTCERC 1630 1640 1650 1660 1670 1680 HPTCDQCKGK GALNCLSCVW SYHLMGGICT SDCLVGEYRV GEGEKFNCEK CHESCMECKG 1690 1700 1710 1720 1730 1740 PGAKNCTLCP ANLVLHMDDS HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH 1750 1760 1770 1780 1790 1800 FKTALFITSS MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST 1810 1820 1830 1840 1850 1860 SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE YDDESYSYYQ
	Isoform PC6A (Short) [UniParc]. Checksum: 7A2E63EFC49104BC	FASTA	913	101,649
	10 20 30 40 50 60 MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA NRIASKYGFI 70 80 90 100 110 120 NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV EWIQQQVVKK RTKRDYDFSR 130 140 150 160 170 180 AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM NIEGAWKRGY TGKNIVVTIL DDGIERTHPD 190 200 210 220 230 240 LMQNYDALAS CDVNGNDLDP MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG 250 260 270 280 290 300 GVRMLDGDVT DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR 310 320 330 340 350 360 RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE CSSTLATTYS 370 380 390 400 410 420 SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL EANPFLTWRD VQHVIVRTSR 430 440 450 460 470 480 AGHLNANDWK TNAAGFKVSH LYGFGLMDAE AMVMEAEKWT TVPRQHVCVE STDRQIKTIR 490 500 510 520 530 540 PNSAVRSIYK ASGCSDNPNR HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR 550 560 570 580 590 600 LFDHSMEGFK NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV 610 620 630 640 650 660 QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP DHCNDCLHYY 670 680 690 700 710 720 YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH GDQCMSCKYG YFLNEETNSC 730 740 750 760 770 780 VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ 790 800 810 820 830 840 DCQPCHRFCA TCAGAGADGC INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI 850 860 870 880 890 900 SCLTCNGPGF KNCTSCPSGY LLDLGMCQMG AICKDATEES WAEGGFCMLV KKNNLCQRKV 910 LQQLCCKTCT FQG

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes." Miranda L., Wolf J., Pichuantes S., Duke R., Franzusoff A. Proc. Natl. Acad. Sci. U.S.A. 93:7695-7700(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC6A), ALTERNATIVE SPLICING. Tissue: T-cell.
[2]	Franzusoff A., Miranda L., Wolf J., Pichuantes S., Lu Y., Duke R. Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases Cited for: SEQUENCE REVISION.
[3]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A). Tissue: Lymph node.
[4]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[5]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A). Tissue: Kidney.
[7]	Reudelhuber T.L. Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-913 (ISOFORM PC6A).
[8]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-1860 (ISOFORM PC6B). Tissue: Tongue.
[9]	"Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment." Kilpatrick L.M., Stephens A.N., Hardman B.M., Salamonsen L.A., Li Y., Stanton P.G., Nie G. J. Proteome Res. 8:4983-4992(2009) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
[10]	"Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment." Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G. Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
[11]	"Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6." Paule S., Aljofan M., Simon C., Rombauts L.J., Nie G. Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U56387 mRNA. Translation: AAC50643.2. AL834522 mRNA. Translation: CAD39178.1. AL359253, AL353607 Genomic DNA. Translation: CAH73743.1. AL353607, AL359253 Genomic DNA. Translation: CAI41233.1. AL391868 Genomic DNA. No translation available. AL589653 Genomic DNA. No translation available. CH471089 Genomic DNA. Translation: EAW62575.1. BC012064 mRNA. Translation: AAH12064.1. U49114 mRNA. Translation: AAA91807.1. AK122718 mRNA. No translation available.
IPI	IPI00294862.
PIR	G02428. JC6148.
RefSeq	NP_001177411.1. NM_001190482.1. NP_006191.2. NM_006200.3.
UniGene	Hs.368542.
3D structure databases
ProteinModelPortal	Q92824.
SMR	Q92824. Positions 128-599.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92824. 4 interactions.
MINT	MINT-1474189.
STRING	9606.ENSP00000365943.
Protein family/group databases
MEROPS	S08.076.
PTM databases
PhosphoSite	Q92824.
Polymorphism databases
DMDM	205830667.
Proteomic databases
PaxDb	Q92824.
PRIDE	Q92824.
Protocols and materials databases
DNASU	5125.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376752; ENSP00000365943; ENSG00000099139. ENST00000545128; ENSP00000446280; ENSG00000099139.
GeneID	5125.
KEGG	hsa:5125.
UCSC	uc004ajz.3. human.
Organism-specific databases
CTD	5125.
GeneCards	GC09P078505.
HGNC	HGNC:8747. PCSK5.
HPA	HPA031072.
MIM	600488. gene.
neXtProt	NX_Q92824.
PharmGKB	PA33093.
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG4935.
HOGENOM	HOG000192536.
HOVERGEN	HBG008705.
KO	K08654.
OMA	LHEGRCY.
Enzyme and pathway databases
Reactome	REACT_111102. Signal Transduction.
Gene expression databases
ArrayExpress	Q92824.
Bgee	Q92824.
CleanEx	HS_PCSK5.
Genevestigator	Q92824.
GermOnline	ENSG00000099139. Homo sapiens.
Family and domain databases
Gene3D	3.40.50.200. 1 hit.
InterPro	IPR000742. EG-like_dom. IPR006212. Furin_repeat. IPR008979. Galactose-bd-like. IPR009030. Growth_fac_rcpt. IPR000209. Peptidase_S8/S53_dom. IPR023827. Peptidase_S8_Asp-AS. IPR022398. Peptidase_S8_His-AS. IPR023828. Peptidase_S8_Ser-AS. IPR015500. Peptidase_S8_subtilisin-rel. IPR009020. Prot_inh_propept. IPR002884. PrprotnconvertsP. [Graphical view]
PANTHER	PTHR10795. PTHR10795. 1 hit.
Pfam	PF01483. P_proprotein. 1 hit. PF00082. Peptidase_S8. 1 hit. [Graphical view]
PRINTS	PR00723. SUBTILISIN.
SMART	SM00181. EGF. 1 hit. SM00261. FU. 22 hits. [Graphical view]
SUPFAM	SSF49785. Gal_bind_like. 1 hit. SSF57184. Grow_fac_recept. 8 hits. SSF52743. Pept_S8_S53. 1 hit. SSF54897. Prot_inh_propept. 1 hit.
PROSITE	PS50900. PLAC. False negative. PS00136. SUBTILASE_ASP. 1 hit. PS00137. SUBTILASE_HIS. 1 hit. PS00138. SUBTILASE_SER. 1 hit. [Graphical view]
ProtoNet	Search...
Other
BindingDB	Q92824.
ChEMBL	CHEMBL2826.
GenomeRNAi	5125.
NextBio	19754.
PMAP-CutDB	Q92824.
SOURCE	Search...

Entry information

Entry name

PCSK5_HUMAN

Accession

Primary (citable) accession number: Q92824
Secondary accession number(s): F5H2G7, Q13527, Q96EP4

Entry history

Integrated into UniProtKB/Swiss-Prot:	January 11, 2001
Last sequence update:	November 16, 2011
Last modified:	April 3, 2013
This is version 134 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.