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Q92824

- PCSK5_HUMAN

UniProt

Q92824 - PCSK5_HUMAN

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Protein

Proprotein convertase subtilisin/kexin type 5

Gene

PCSK5

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Likely to represent a widespread endoprotease activity within the constitutive and regulated secretory pathway. Capable of cleavage at the RX(K/R)R consensus motif. Plays an essential role in pregnancy establishment by proteolytic activation of a number of important factors such as BMP2, CALD1 and alpha-integrins.3 Publications

Catalytic activityi

Release of mature proteins from their proproteins by cleavage of Arg-Xaa-Yaa-Arg-|-Zaa bonds, where Xaa can be any amino acid and Yaa is Arg or Lys.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei114 – 1152Cleavage; by autolysisBy similarity
Active sitei171 – 1711Charge relay systemBy similarity
Active sitei212 – 2121Charge relay systemBy similarity
Active sitei386 – 3861Charge relay systemBy similarity

GO - Molecular functioni

  1. peptidase activity Source: MGI
  2. peptide binding Source: BHF-UCL
  3. serine-type endopeptidase activity Source: BHF-UCL

GO - Biological processi

  1. anterior/posterior pattern specification Source: BHF-UCL
  2. cell-cell signaling Source: ProtInc
  3. cytokine biosynthetic process Source: BHF-UCL
  4. embryo implantation Source: BHF-UCL
  5. embryonic digestive tract development Source: BHF-UCL
  6. embryonic skeletal system development Source: BHF-UCL
  7. heart development Source: BHF-UCL
  8. kidney development Source: BHF-UCL
  9. limb morphogenesis Source: BHF-UCL
  10. nerve growth factor processing Source: Reactome
  11. neurotrophin TRK receptor signaling pathway Source: Reactome
  12. peptide biosynthetic process Source: BHF-UCL
  13. peptide hormone processing Source: BHF-UCL
  14. protein processing Source: BHF-UCL
  15. renin secretion into blood stream Source: BHF-UCL
  16. respiratory tube development Source: BHF-UCL
  17. signal peptide processing Source: HGNC
  18. viral life cycle Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protease, Serine protease

Keywords - Biological processi

Pregnancy

Enzyme and pathway databases

ReactomeiREACT_11062. NGF processing.
SignaLinkiQ92824.

Protein family/group databases

MEROPSiS08.076.

Names & Taxonomyi

Protein namesi
Recommended name:
Proprotein convertase subtilisin/kexin type 5 (EC:3.4.21.-)
Alternative name(s):
Proprotein convertase 5
Short name:
PC5
Proprotein convertase 6
Short name:
PC6
Short name:
hPC6
Subtilisin/kexin-like protease PC5
Gene namesi
Name:PCSK5
Synonyms:PC5, PC6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:8747. PCSK5.

Subcellular locationi

Isoform PC6A : Secreted
Note: Secreted through the regulated secretory pathway.By similarity
Isoform PC6B : Endomembrane system; Single-pass type I membrane protein
Note: Type I membrane protein localized to a paranuclear post-Golgi network compartment in communication with early endosomes.By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini115 – 17431629ExtracellularSequence AnalysisAdd
BLAST
Transmembranei1744 – 176421HelicalSequence AnalysisAdd
BLAST
Topological domaini1765 – 186096CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. extracellular space Source: BHF-UCL
  2. Golgi apparatus Source: BHF-UCL
  3. Golgi lumen Source: Reactome
  4. integral component of membrane Source: UniProtKB-KW
  5. secretory granule Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Membrane, Secreted

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33093.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3232By similarityAdd
BLAST
Propeptidei33 – 11482By similarityPRO_0000027102Add
BLAST
Chaini115 – 18601746Proprotein convertase subtilisin/kexin type 5PRO_0000027103Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi225 – 2251N-linked (GlcNAc...)Sequence Analysis
Glycosylationi381 – 3811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi665 – 6651N-linked (GlcNAc...)Sequence Analysis
Glycosylationi752 – 7521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi852 – 8521N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1014 – 10141N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1191 – 11911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1290 – 12901N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1497 – 14971N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1685 – 16851N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1707 – 17071N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Cleavage on pair of basic residues, Glycoprotein, Zymogen

Proteomic databases

PaxDbiQ92824.
PRIDEiQ92824.

PTM databases

PhosphoSiteiQ92824.

Miscellaneous databases

PMAP-CutDBQ92824.

Expressioni

Tissue specificityi

Expressed in T-lymphocytes.

Gene expression databases

BgeeiQ92824.
CleanExiHS_PCSK5.
ExpressionAtlasiQ92824. baseline and differential.
GenevestigatoriQ92824.

Organism-specific databases

HPAiHPA031072.

Interactioni

Protein-protein interaction databases

BioGridi111152. 11 interactions.
IntActiQ92824. 4 interactions.
MINTiMINT-1474189.
STRINGi9606.ENSP00000365943.

Structurei

3D structure databases

ProteinModelPortaliQ92824.
SMRiQ92824. Positions 128-599.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini166 – 453288Peptidase S8Add
BLAST
Repeati630 – 68051FU 1Add
BLAST
Repeati683 – 73048FU 2Add
BLAST
Repeati734 – 77744FU 3Add
BLAST
Repeati779 – 82446FU 4Add
BLAST
Repeati832 – 87948FU 5Add
BLAST
Domaini869 – 91345PLACAdd
BLAST
Repeati882 – 92746FU 6Add
BLAST
Repeati929 – 97951FU 7Add
BLAST
Repeati982 – 102847FU 8Add
BLAST
Repeati1032 – 107746FU 9Add
BLAST
Repeati1079 – 112143FU 10Add
BLAST
Repeati1125 – 116844FU 11Add
BLAST
Repeati1177 – 122145FU 12Add
BLAST
Repeati1225 – 127248FU 13Add
BLAST
Repeati1274 – 131845FU 14Add
BLAST
Repeati1320 – 136344FU 15Add
BLAST
Repeati1365 – 141147FU 16Add
BLAST
Repeati1415 – 146147FU 17Add
BLAST
Repeati1465 – 151046FU 18Add
BLAST
Repeati1514 – 155946FU 19Add
BLAST
Repeati1563 – 161048FU 20Add
BLAST
Repeati1614 – 165946FU 21Add
BLAST
Repeati1665 – 171248FU 22Add
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni636 – 17271092CRM (Cys-rich motif)Add
BLAST
Regioni1807 – 182620AC 1By similarityAdd
BLAST
Regioni1838 – 186023AC 2By similarityAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi519 – 5213Cell attachment siteSequence Analysis

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi1812 – 185342Asp-richAdd
BLAST

Domaini

The propeptide domain acts as an intramolecular chaperone assisting the folding of the zymogen within the endoplasmic reticulum.
AC 1 and AC 2 (clusters of acidic amino acids) contain sorting information. AC 1 directs TGN localization and interacts with the TGN sorting protein PACS-1 (By similarity).By similarity

Sequence similaritiesi

Belongs to the peptidase S8 family.Curated
Contains 22 FU (furin-like) repeats.Curated
Contains 1 peptidase S8 domain.Curated
Contains 1 PLAC domain.Curated

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG4935.
GeneTreeiENSGT00750000117358.
HOGENOMiHOG000192536.
HOVERGENiHBG008705.
InParanoidiQ92824.
KOiK08654.
OMAiLHEGRCY.
PhylomeDBiQ92824.
TreeFamiTF314277.

Family and domain databases

Gene3Di2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProiIPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view]
PANTHERiPTHR10795. PTHR10795. 1 hit.
PfamiPF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view]
PRINTSiPR00723. SUBTILISIN.
SMARTiSM00181. EGF. 1 hit.
SM00261. FU. 22 hits.
[Graphical view]
SUPFAMiSSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 7 hits.
PROSITEiPS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform PC6B (identifier: Q92824-1) [UniParc]FASTAAdd to Basket

Also known as: Long

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGWGSRCCCP GRLDLLCVLA LLGGCLLPVC RTRVYTNHWA VKIAGGFPEA
60 70 80 90 100
NRIASKYGFI NIGQIGALKD YYHFYHSRTI KRSVISSRGT HSFISMEPKV
110 120 130 140 150
EWIQQQVVKK RTKRDYDFSR AQSTYFNDPK WPSMWYMHCS DNTHPCQSDM
160 170 180 190 200
NIEGAWKRGY TGKNIVVTIL DDGIERTHPD LMQNYDALAS CDVNGNDLDP
210 220 230 240 250
MPRYDASNEN KHGTRCAGEV AAAANNSHCT VGIAFNAKIG GVRMLDGDVT
260 270 280 290 300
DMVEAKSVSF NPQHVHIYSA SWGPDDDGKT VDGPAPLTRQ AFENGVRMGR
310 320 330 340 350
RGLGSVFVWA SGNGGRSKDH CSCDGYTNSI YTISISSTAE SGKKPWYLEE
360 370 380 390 400
CSSTLATTYS SGESYDKKII TTDLRQRCTD NHTGTSASAP MAAGIIALAL
410 420 430 440 450
EANPFLTWRD VQHVIVRTSR AGHLNANDWK TNAAGFKVSH LYGFGLMDAE
460 470 480 490 500
AMVMEAEKWT TVPRQHVCVE STDRQIKTIR PNSAVRSIYK ASGCSDNPNR
510 520 530 540 550
HVNYLEHVVV RITITHPRRG DLAIYLTSPS GTRSQLLANR LFDHSMEGFK
560 570 580 590 600
NWEFMTIHCW GERAAGDWVL EVYDTPSQLR NFKTPGKLKE WSLVLYGTSV
610 620 630 640 650
QPYSPTNEFP KVERFRYSRV EDPTDDYGTE DYAGPCDPEC SEVGCDGPGP
660 670 680 690 700
DHCNDCLHYY YKLKNNTRIC VSSCPPGHYH ADKKRCRKCA PNCESCFGSH
710 720 730 740 750
GDQCMSCKYG YFLNEETNSC VTHCPDGSYQ DTKKNLCRKC SENCKTCTEF
760 770 780 790 800
HNCTECRDGL SLQGSRCSVS CEDGRYFNGQ DCQPCHRFCA TCAGAGADGC
810 820 830 840 850
INCTEGYFME DGRCVQSCSI SYYFDHSSEN GYKSCKKCDI SCLTCNGPGF
860 870 880 890 900
KNCTSCPSGY LLDLGMCQMG AICKDGEYVD EHGHCQTCEA SCAKCQGPTQ
910 920 930 940 950
EDCTTCPMTR IFDDGRCVSN CPSWKFEFEN QCHPCHHTCQ RCQGSGPTHC
960 970 980 990 1000
TSCGADNYGR EHFLYQGECG DSCPEGHYAT EGNTCLPCPD NCELCHSVHV
1010 1020 1030 1040 1050
CTRCMKGYFI APTNHTCQKL ECGQGEVQDP DYEECVPCEE GCLGCSLDDP
1060 1070 1080 1090 1100
GTCTSCAMGY YRFDHHCYKT CPEKTYSEEV ECKACDSNCG SCDQNGCYWC
1110 1120 1130 1140 1150
EEGFFLLGGS CVRKCGPGFY GDQEMGECES CHRACETCTG PGHDECSSCQ
1160 1170 1180 1190 1200
EGLQLLRGMC VHATKTQEEG KFWNDILRKL QPCHSSCKTC NGSATLCTSC
1210 1220 1230 1240 1250
PKGAYLLAQA CVSSCPQGTW PSVRSGSCEN CTEACAICSG ADLCKKCQMQ
1260 1270 1280 1290 1300
PGHPLFLHEG RCYSKCPEGS YAEDGICERC SSPCRTCEGN ATNCHSCEGG
1310 1320 1330 1340 1350
HVLHHGVCQE NCPERHVAVK GVCKHCPEMC QDCIHEKTCK ECTPEFFLHD
1360 1370 1380 1390 1400
DMCHQSCPRG FYADSRHCVP CHKDCLECSG PKADDCELCL ESSWVLYDGL
1410 1420 1430 1440 1450
CLEECPAGTY YEKETKECRD CHKSCLTCSS SGTCTTCQKG LIMNPRGSCM
1460 1470 1480 1490 1500
ANEKCSPSEY WDEDAPGCKP CHVKCFHCMG PAEDQCQTCP MNSLLLNTTC
1510 1520 1530 1540 1550
VKDCPEGYYA DEDSNRCAHC HSSCRTCEGR HSRQCHSCRP GWFQLGKECL
1560 1570 1580 1590 1600
LQCREGYYAD NSTGRCERCN RSCKGCQGPR PTDCLSCDRF FFLLRSKGEC
1610 1620 1630 1640 1650
HRSCPDHYYV EQSTQTCERC HPTCDQCKGK GALNCLSCVW SYHLMGGICT
1660 1670 1680 1690 1700
SDCLVGEYRV GEGEKFNCEK CHESCMECKG PGAKNCTLCP ANLVLHMDDS
1710 1720 1730 1740 1750
HCLHCCNTSD PPSAQECCDC QDTTDECILR TSKVRPATEH FKTALFITSS
1760 1770 1780 1790 1800
MMLVLLLGAA VVVWKKSRGR VQPAAKAGYE KLADPNKSYS SYKSSYREST
1810 1820 1830 1840 1850
SFEEDQVIEY RDRDYDEDDD DDIVYMGQDG TVYRKFKYGL LDDDDIDELE
1860
YDDESYSYYQ
Length:1,860
Mass (Da):206,942
Last modified:November 16, 2011 - v4
Checksum:i96B3E7C8215BCC85
GO
Isoform PC6A (identifier: Q92824-2) [UniParc]FASTAAdd to Basket

Also known as: Short

The sequence of this isoform differs from the canonical sequence as follows:
     876-913: GEYVDEHGHC...TTCPMTRIFD → ATEESWAEGG...LCCKTCTFQG
     914-1860: Missing.

Show »
Length:913
Mass (Da):101,649
Checksum:i7A2E63EFC49104BC
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti2 – 21G → D in AAC50643. (PubMed:8755538)Curated
Sequence conflicti4 – 41G → E in AAC50643. (PubMed:8755538)Curated
Sequence conflicti118 – 1181F → S in AAC50643. (PubMed:8755538)Curated
Sequence conflicti121 – 1211A → V in AAC50643. (PubMed:8755538)Curated
Sequence conflicti511 – 5111R → A in AAA91807. 1 PublicationCurated
Sequence conflicti601 – 6011Q → R in AAC50643. (PubMed:8755538)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei876 – 91338GEYVD…TRIFD → ATEESWAEGGFCMLVKKNNL CQRKVLQQLCCKTCTFQG in isoform PC6A. 4 PublicationsVSP_042017Add
BLAST
Alternative sequencei914 – 1860947Missing in isoform PC6A. 4 PublicationsVSP_042018Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56387 mRNA. Translation: AAC50643.2.
AL834522 mRNA. Translation: CAD39178.1.
AL359253, AL353607 Genomic DNA. Translation: CAH73743.1.
AL353607, AL359253 Genomic DNA. Translation: CAI41233.1.
AL391868 Genomic DNA. No translation available.
AL589653 Genomic DNA. No translation available.
CH471089 Genomic DNA. Translation: EAW62575.1.
BC012064 mRNA. Translation: AAH12064.1.
U49114 mRNA. Translation: AAA91807.1.
AK122718 mRNA. No translation available.
CCDSiCCDS55320.1. [Q92824-1]
CCDS6652.1. [Q92824-2]
PIRiG02428.
JC6148.
RefSeqiNP_001177411.1. NM_001190482.1. [Q92824-1]
NP_006191.2. NM_006200.5. [Q92824-2]
UniGeneiHs.368542.
Hs.732073.

Genome annotation databases

EnsembliENST00000376752; ENSP00000365943; ENSG00000099139. [Q92824-2]
ENST00000545128; ENSP00000446280; ENSG00000099139. [Q92824-1]
GeneIDi5125.
KEGGihsa:5125.
UCSCiuc004ajz.3. human. [Q92824-2]
uc004akc.2. human. [Q92824-1]

Polymorphism databases

DMDMi357529585.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U56387 mRNA. Translation: AAC50643.2 .
AL834522 mRNA. Translation: CAD39178.1 .
AL359253 , AL353607 Genomic DNA. Translation: CAH73743.1 .
AL353607 , AL359253 Genomic DNA. Translation: CAI41233.1 .
AL391868 Genomic DNA. No translation available.
AL589653 Genomic DNA. No translation available.
CH471089 Genomic DNA. Translation: EAW62575.1 .
BC012064 mRNA. Translation: AAH12064.1 .
U49114 mRNA. Translation: AAA91807.1 .
AK122718 mRNA. No translation available.
CCDSi CCDS55320.1. [Q92824-1 ]
CCDS6652.1. [Q92824-2 ]
PIRi G02428.
JC6148.
RefSeqi NP_001177411.1. NM_001190482.1. [Q92824-1 ]
NP_006191.2. NM_006200.5. [Q92824-2 ]
UniGenei Hs.368542.
Hs.732073.

3D structure databases

ProteinModelPortali Q92824.
SMRi Q92824. Positions 128-599.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111152. 11 interactions.
IntActi Q92824. 4 interactions.
MINTi MINT-1474189.
STRINGi 9606.ENSP00000365943.

Chemistry

ChEMBLi CHEMBL2826.

Protein family/group databases

MEROPSi S08.076.

PTM databases

PhosphoSitei Q92824.

Polymorphism databases

DMDMi 357529585.

Proteomic databases

PaxDbi Q92824.
PRIDEi Q92824.

Protocols and materials databases

DNASUi 5125.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376752 ; ENSP00000365943 ; ENSG00000099139 . [Q92824-2 ]
ENST00000545128 ; ENSP00000446280 ; ENSG00000099139 . [Q92824-1 ]
GeneIDi 5125.
KEGGi hsa:5125.
UCSCi uc004ajz.3. human. [Q92824-2 ]
uc004akc.2. human. [Q92824-1 ]

Organism-specific databases

CTDi 5125.
GeneCardsi GC09P078505.
HGNCi HGNC:8747. PCSK5.
HPAi HPA031072.
MIMi 600488. gene.
neXtProti NX_Q92824.
PharmGKBi PA33093.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG4935.
GeneTreei ENSGT00750000117358.
HOGENOMi HOG000192536.
HOVERGENi HBG008705.
InParanoidi Q92824.
KOi K08654.
OMAi LHEGRCY.
PhylomeDBi Q92824.
TreeFami TF314277.

Enzyme and pathway databases

Reactomei REACT_11062. NGF processing.
SignaLinki Q92824.

Miscellaneous databases

ChiTaRSi PCSK5. human.
GeneWikii PCSK5.
GenomeRNAii 5125.
NextBioi 19754.
PMAP-CutDB Q92824.
PROi Q92824.
SOURCEi Search...

Gene expression databases

Bgeei Q92824.
CleanExi HS_PCSK5.
ExpressionAtlasi Q92824. baseline and differential.
Genevestigatori Q92824.

Family and domain databases

Gene3Di 2.60.120.260. 1 hit.
3.40.50.200. 1 hit.
InterProi IPR000742. EG-like_dom.
IPR006212. Furin_repeat.
IPR008979. Galactose-bd-like.
IPR009030. Growth_fac_rcpt_N_dom.
IPR000209. Peptidase_S8/S53_dom.
IPR023827. Peptidase_S8_Asp-AS.
IPR022398. Peptidase_S8_His-AS.
IPR023828. Peptidase_S8_Ser-AS.
IPR015500. Peptidase_S8_subtilisin-rel.
IPR009020. Prot_inh_propept.
IPR002884. PrprotnconvertsP.
[Graphical view ]
PANTHERi PTHR10795. PTHR10795. 1 hit.
Pfami PF01483. P_proprotein. 1 hit.
PF00082. Peptidase_S8. 1 hit.
[Graphical view ]
PRINTSi PR00723. SUBTILISIN.
SMARTi SM00181. EGF. 1 hit.
SM00261. FU. 22 hits.
[Graphical view ]
SUPFAMi SSF49785. SSF49785. 1 hit.
SSF52743. SSF52743. 1 hit.
SSF54897. SSF54897. 1 hit.
SSF57184. SSF57184. 7 hits.
PROSITEi PS00136. SUBTILASE_ASP. 1 hit.
PS00137. SUBTILASE_HIS. 1 hit.
PS00138. SUBTILASE_SER. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation of the human PC6 gene encoding the putative host protease for HIV-1 gp160 processing in CD4+ T lymphocytes."
    Miranda L., Wolf J., Pichuantes S., Duke R., Franzusoff A.
    Proc. Natl. Acad. Sci. U.S.A. 93:7695-7700(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM PC6A), ALTERNATIVE SPLICING.
    Tissue: T-cell.
  2. Franzusoff A., Miranda L., Wolf J., Pichuantes S., Lu Y., Duke R.
    Submitted (JUL-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: SEQUENCE REVISION.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
    Tissue: Lymph node.
  4. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM PC6A).
    Tissue: Kidney.
  7. Reudelhuber T.L.
    Submitted (FEB-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 15-913 (ISOFORM PC6A).
  8. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-1860 (ISOFORM PC6B).
    Tissue: Tongue.
  9. "Proteomic identification of caldesmon as a physiological substrate of proprotein convertase 6 in human uterine decidual cells essential for pregnancy establishment."
    Kilpatrick L.M., Stephens A.N., Hardman B.M., Salamonsen L.A., Li Y., Stanton P.G., Nie G.
    J. Proteome Res. 8:4983-4992(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
  10. "Posttranslational activation of bone morphogenetic protein 2 is mediated by proprotein convertase 6 during decidualization for pregnancy establishment."
    Heng S., Paule S., Hardman B., Li Y., Singh H., Rainczuk A., Stephens A.N., Nie G.
    Endocrinology 151:3909-3917(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION IN PREGNANCY ESTABLISHMENT.
  11. "Cleavage of endometrial alpha-integrins into their functional forms is mediated by proprotein convertase 5/6."
    Paule S., Aljofan M., Simon C., Rombauts L.J., Nie G.
    Hum. Reprod. 27:2766-2774(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.

Entry informationi

Entry nameiPCSK5_HUMAN
AccessioniPrimary (citable) accession number: Q92824
Secondary accession number(s): F5H2G7, Q13527, Q96EP4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: November 16, 2011
Last modified: November 26, 2014
This is version 150 of the entry and version 4 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. Peptidase families
    Classification of peptidase families and list of entries
  4. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3