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Q92823

- NRCAM_HUMAN

UniProt

Q92823 - NRCAM_HUMAN

Protein

Neuronal cell adhesion molecule

Gene

NRCAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 142 (01 Oct 2014)
      Sequence version 3 (25 Nov 2008)
      Previous versions | rss
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    Functioni

    Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier By similarity.By similarity

    GO - Molecular functioni

    1. ankyrin binding Source: UniProtKB
    2. protein binding Source: UniProtKB

    GO - Biological processi

    1. angiogenesis Source: UniProtKB
    2. axonal fasciculation Source: UniProtKB
    3. axon guidance Source: Reactome
    4. axonogenesis Source: UniProtKB
    5. central nervous system development Source: UniProtKB
    6. clustering of voltage-gated sodium channels Source: UniProtKB
    7. heterotypic cell-cell adhesion Source: Ensembl
    8. neuronal action potential propagation Source: Ensembl
    9. neuron migration Source: UniProtKB
    10. positive regulation of neuron differentiation Source: UniProtKB
    11. protein localization Source: Ensembl
    12. regulation of axon extension Source: UniProtKB
    13. retinal ganglion cell axon guidance Source: Ensembl
    14. single organismal cell-cell adhesion Source: UniProtKB
    15. synapse assembly Source: UniProtKB

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_22266. Interaction between L1 and Ankyrins.
    REACT_22312. Neurofascin interactions.
    REACT_22329. NrCAM interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neuronal cell adhesion molecule
    Short name:
    Nr-CAM
    Alternative name(s):
    Neuronal surface protein Bravo
    Short name:
    hBravo
    NgCAM-related cell adhesion molecule
    Short name:
    Ng-CAM-related
    Gene namesi
    Name:NRCAM
    Synonyms:KIAA0343
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 7

    Organism-specific databases

    HGNCiHGNC:7994. NRCAM.

    Subcellular locationi

    GO - Cellular componenti

    1. axon initial segment Source: BHF-UCL
    2. external side of plasma membrane Source: UniProtKB
    3. integral component of plasma membrane Source: UniProtKB
    4. neuron projection Source: UniProtKB
    5. plasma membrane Source: Reactome
    6. synapse Source: Ensembl

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA31773.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 2424Sequence AnalysisAdd
    BLAST
    Chaini25 – 13041280Neuronal cell adhesion moleculePRO_0000015057Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi68 ↔ 123PROSITE-ProRule annotation
    Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi167 ↔ 218PROSITE-ProRule annotation
    Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi276 – 2761N-linked (GlcNAc...)2 Publications
    Disulfide bondi292 ↔ 340PROSITE-ProRule annotation
    Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi382 ↔ 432PROSITE-ProRule annotation
    Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi476 ↔ 525PROSITE-ProRule annotation
    Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi567 ↔ 616PROSITE-ProRule annotation
    Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi858 – 8581N-linked (GlcNAc...) (complex)1 Publication
    Glycosylationi993 – 9931N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1019 – 10191N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1072 – 10721N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1083 – 10831N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi1115 – 11151N-linked (GlcNAc...)Sequence Analysis
    Modified residuei1271 – 12711PhosphoserineBy similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ92823.
    PaxDbiQ92823.
    PRIDEiQ92823.

    PTM databases

    PhosphoSiteiQ92823.

    Expressioni

    Tissue specificityi

    Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

    Gene expression databases

    ArrayExpressiQ92823.
    BgeeiQ92823.
    CleanExiHS_NRCAM.
    GenevestigatoriQ92823.

    Organism-specific databases

    HPAiHPA012606.

    Interactioni

    Subunit structurei

    Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin By similarity. Interacts with MYOC.By similarity1 Publication

    Protein-protein interaction databases

    BioGridi110953. 7 interactions.
    IntActiQ92823. 5 interactions.
    STRINGi9606.ENSP00000368314.

    Structurei

    Secondary structure

    1
    1304
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi651 – 6566
    Beta strandi659 – 6613
    Beta strandi663 – 6686
    Beta strandi677 – 68610
    Turni687 – 6893
    Beta strandi694 – 70310
    Beta strandi706 – 7094
    Beta strandi720 – 7278
    Beta strandi853 – 8586
    Beta strandi861 – 8655
    Helixi871 – 8744
    Beta strandi878 – 88912
    Beta strandi901 – 9099
    Beta strandi911 – 9177
    Beta strandi923 – 93412
    Beta strandi936 – 9394
    Beta strandi943 – 9464

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    1UENNMR-A839-950[»]
    1UEYNMR-A638-751[»]
    ProteinModelPortaliQ92823.
    SMRiQ92823. Positions 42-835, 842-1143.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92823.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini25 – 11671143ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini1191 – 1304114CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei1168 – 119023HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini46 – 13489Ig-like 1Add
    BLAST
    Domaini141 – 23595Ig-like 2Add
    BLAST
    Domaini267 – 35690Ig-like 3Add
    BLAST
    Domaini361 – 44888Ig-like 4Add
    BLAST
    Domaini454 – 54188Ig-like 5Add
    BLAST
    Domaini545 – 63288Ig-like 6Add
    BLAST
    Domaini649 – 74496Fibronectin type-III 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini746 – 84398Fibronectin type-III 2PROSITE-ProRule annotationAdd
    BLAST
    Domaini848 – 950103Fibronectin type-III 3PROSITE-ProRule annotationAdd
    BLAST
    Domaini954 – 105198Fibronectin type-III 4PROSITE-ProRule annotationAdd
    BLAST
    Domaini1064 – 115693Fibronectin type-III 5PROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG293951.
    HOGENOMiHOG000231380.
    HOVERGENiHBG000144.
    KOiK06756.
    OMAiYANISWE.
    OrthoDBiEOG7R56RM.
    PhylomeDBiQ92823.
    TreeFamiTF351098.

    Family and domain databases

    Gene3Di2.60.40.10. 11 hits.
    InterProiIPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    [Graphical view]
    PfamiPF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 5 hits.
    PF07679. I-set. 4 hits.
    [Graphical view]
    SMARTiSM00060. FN3. 5 hits.
    SM00409. IG. 3 hits.
    SM00408. IGc2. 3 hits.
    [Graphical view]
    SUPFAMiSSF49265. SSF49265. 3 hits.
    PROSITEiPS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 6 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view]

    Sequences (6)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 6 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92823-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ     50
    QSPKDYIIDP RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG 100
    TGTLIINIMS EGKAETYEGV YQCTARNERG AAVSNNIVVR PSRSPLWTKE 150
    KLEPITLQSG QSLVLPCRPP IGLPPPIIFW MDNSFQRLPQ SERVSQGLNG 200
    DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS VDELNDTIAA 250
    NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP 300
    IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH 350
    HTISVRVKAA PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP 400
    IEIAPDDPSR KIDGDTIIFS NVQERSSAVY QCNASNEYGY LLANAFVNVL 450
    AEPPRILTPA NTLYQVIANR PALLDCAFFG SPLPTIEWFK GAKGSALHED 500
    IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL EIKDPTWIVK 550
    QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH 600
    LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP 650
    FDLELTDQLD KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV 700
    SGTQTTAQLK LSPYVNYSFR VMAVNSIGKS LPSEASEQYL TKASEPDKNP 750
    TAVEGLGSEP DNLVITWKPL NGFESNGPGL QYKVSWRQKD GDDEWTSVVV 800
    ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS GEDLPMVAPG 850
    NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE 900
    KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG 950
    VPSAPSSLKI VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP 1000
    LVDLKIPANK TRWTLKNLNF STRYKFYFYA QTSAGSGSQI TEEAVTTVDE 1050
    AGILPPDVGA GKVQAVNPRI SNLTAAAAET YANISWEYEG PEHVNFYVEY 1100
    GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG DSGFVSSEDV 1150
    FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV 1200
    KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED 1250
    SDDSLVDYGE GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM 1300
    NSFV 1304
    Length:1,304
    Mass (Da):143,890
    Last modified:November 25, 2008 - v3
    Checksum:i1F2698BC7DB5C363
    GO
    Isoform 2 (identifier: Q92823-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1226-1236: SDAEDHKPLKK → RLFSFVSSASF
         1237-1304: Missing.

    Show »
    Length:1,236
    Mass (Da):136,614
    Checksum:i0C21479D02E6CCE2
    GO
    Isoform 3 (identifier: Q92823-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-259: Missing.
         1051-1155: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,180
    Mass (Da):130,668
    Checksum:iDF33D4380A609B75
    GO
    Isoform 4 (identifier: Q92823-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         35-40: Missing.
         635-644: Missing.
         1051-1155: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,183
    Mass (Da):131,046
    Checksum:iFEF6A39C50DE9664
    GO
    Isoform 5 (identifier: Q92823-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1225-1225: Y → YRSLE

    Show »
    Length:1,308
    Mass (Da):144,375
    Checksum:i7019F3533A0F445E
    GO
    Isoform 6 (identifier: Q92823-6) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         241-259: Missing.
         1063-1155: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:1,192
    Mass (Da):131,744
    Checksum:i0D9E6E1CDB666115
    GO

    Sequence cautioni

    The sequence AAC50765.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAA20801.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti487 – 4871E → Q in CAA04507. 1 PublicationCurated
    Sequence conflicti512 – 5121I → IKDATWIVKEI in AAC50765. (PubMed:8812479)Curated
    Sequence conflicti541 – 55010Missing in AAC50765. (PubMed:8812479)Curated
    Sequence conflicti651 – 6511F → L in CAA04507. 1 PublicationCurated
    Sequence conflicti679 – 6824KFII → TIHD in CAA04507. 1 PublicationCurated
    Sequence conflicti710 – 7101K → N in BAA20801. (PubMed:9205841)Curated
    Sequence conflicti764 – 7641V → E in AAC50765. (PubMed:8812479)Curated
    Sequence conflicti775 – 7751S → F in CAA04507. 1 PublicationCurated
    Sequence conflicti790 – 7901D → V in CAA04507. 1 PublicationCurated
    Sequence conflicti921 – 9211F → L in CAD97960. (PubMed:17974005)Curated
    Sequence conflicti954 – 9541A → V in CAA04507. 1 PublicationCurated
    Sequence conflicti994 – 9941S → N in CAA04507. 1 PublicationCurated
    Sequence conflicti1008 – 10081A → T in CAD97960. (PubMed:17974005)Curated
    Sequence conflicti1021 – 10211S → T in CAA04507. 1 PublicationCurated
    Sequence conflicti1068 – 10681P → T in AAC50765. (PubMed:8812479)Curated
    Sequence conflicti1093 – 10942HV → YA in CAA04507. 1 PublicationCurated
    Sequence conflicti1134 – 11341V → F in CAA04507. 1 PublicationCurated
    Sequence conflicti1141 – 11433DSG → GPR in CAA04507. 1 PublicationCurated
    Sequence conflicti1149 – 11491D → G in CAA04507. 1 PublicationCurated
    Sequence conflicti1256 – 12561V → L in CAA04507. 1 PublicationCurated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti545 – 5451P → A.4 Publications
    Corresponds to variant rs6958498 [ dbSNP | Ensembl ].
    VAR_047550
    Natural varianti1093 – 10931H → P in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035528
    Natural varianti1116 – 11161G → V in a breast cancer sample; somatic mutation. 1 Publication
    VAR_035529

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei35 – 406Missing in isoform 4. 1 PublicationVSP_007837
    Alternative sequencei241 – 25919Missing in isoform 3 and isoform 6. 2 PublicationsVSP_007838Add
    BLAST
    Alternative sequencei635 – 64410Missing in isoform 4. 1 PublicationVSP_007839
    Alternative sequencei1051 – 1155105Missing in isoform 3 and isoform 4. 2 PublicationsVSP_007840Add
    BLAST
    Alternative sequencei1063 – 115593Missing in isoform 6. 1 PublicationVSP_045040Add
    BLAST
    Alternative sequencei1225 – 12251Y → YRSLE in isoform 5. CuratedVSP_007843
    Alternative sequencei1226 – 123611SDAEDHKPLKK → RLFSFVSSASF in isoform 2. CuratedVSP_007841Add
    BLAST
    Alternative sequencei1237 – 130468Missing in isoform 2. CuratedVSP_007842Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55258 Genomic DNA. Translation: AAC50765.1. Different initiation.
    AF172277 Genomic DNA. Translation: AAF22282.1.
    AF172277 Genomic DNA. Translation: AAF22283.1.
    AB002341 mRNA. Translation: BAA20801.2. Different initiation.
    BX538010 mRNA. Translation: CAD97960.1.
    AC005683 Genomic DNA. No translation available.
    AC007567 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24386.1.
    CH471070 Genomic DNA. Translation: EAW83429.1.
    BC115736 mRNA. Translation: AAI15737.1.
    AJ001054 mRNA. Translation: CAA04504.1.
    AJ001057 mRNA. Translation: CAA04507.1.
    CCDSiCCDS47686.1. [Q92823-1]
    CCDS55153.1. [Q92823-6]
    CCDS5751.1. [Q92823-4]
    RefSeqiNP_001032209.1. NM_001037132.2. [Q92823-1]
    NP_001180511.1. NM_001193582.1.
    NP_001180512.1. NM_001193583.1. [Q92823-6]
    NP_001180513.1. NM_001193584.1. [Q92823-3]
    NP_005001.3. NM_005010.4. [Q92823-4]
    XP_005250430.1. XM_005250373.2. [Q92823-1]
    XP_006716066.1. XM_006716003.1. [Q92823-5]
    XP_006716067.1. XM_006716004.1. [Q92823-5]
    UniGeneiHs.21422.

    Genome annotation databases

    EnsembliENST00000351718; ENSP00000325269; ENSG00000091129. [Q92823-4]
    ENST00000379024; ENSP00000368310; ENSG00000091129. [Q92823-6]
    ENST00000379028; ENSP00000368314; ENSG00000091129. [Q92823-1]
    ENST00000425651; ENSP00000401244; ENSG00000091129. [Q92823-1]
    GeneIDi4897.
    KEGGihsa:4897.
    UCSCiuc003vfc.3. human. [Q92823-4]
    uc003vfe.3. human. [Q92823-3]
    uc011kmk.2. human. [Q92823-1]

    Polymorphism databases

    DMDMi215274127.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U55258 Genomic DNA. Translation: AAC50765.1 . Different initiation.
    AF172277 Genomic DNA. Translation: AAF22282.1 .
    AF172277 Genomic DNA. Translation: AAF22283.1 .
    AB002341 mRNA. Translation: BAA20801.2 . Different initiation.
    BX538010 mRNA. Translation: CAD97960.1 .
    AC005683 Genomic DNA. No translation available.
    AC007567 Genomic DNA. No translation available.
    CH236947 Genomic DNA. Translation: EAL24386.1 .
    CH471070 Genomic DNA. Translation: EAW83429.1 .
    BC115736 mRNA. Translation: AAI15737.1 .
    AJ001054 mRNA. Translation: CAA04504.1 .
    AJ001057 mRNA. Translation: CAA04507.1 .
    CCDSi CCDS47686.1. [Q92823-1 ]
    CCDS55153.1. [Q92823-6 ]
    CCDS5751.1. [Q92823-4 ]
    RefSeqi NP_001032209.1. NM_001037132.2. [Q92823-1 ]
    NP_001180511.1. NM_001193582.1.
    NP_001180512.1. NM_001193583.1. [Q92823-6 ]
    NP_001180513.1. NM_001193584.1. [Q92823-3 ]
    NP_005001.3. NM_005010.4. [Q92823-4 ]
    XP_005250430.1. XM_005250373.2. [Q92823-1 ]
    XP_006716066.1. XM_006716003.1. [Q92823-5 ]
    XP_006716067.1. XM_006716004.1. [Q92823-5 ]
    UniGenei Hs.21422.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    1UEN NMR - A 839-950 [» ]
    1UEY NMR - A 638-751 [» ]
    ProteinModelPortali Q92823.
    SMRi Q92823. Positions 42-835, 842-1143.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110953. 7 interactions.
    IntActi Q92823. 5 interactions.
    STRINGi 9606.ENSP00000368314.

    PTM databases

    PhosphoSitei Q92823.

    Polymorphism databases

    DMDMi 215274127.

    Proteomic databases

    MaxQBi Q92823.
    PaxDbi Q92823.
    PRIDEi Q92823.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000351718 ; ENSP00000325269 ; ENSG00000091129 . [Q92823-4 ]
    ENST00000379024 ; ENSP00000368310 ; ENSG00000091129 . [Q92823-6 ]
    ENST00000379028 ; ENSP00000368314 ; ENSG00000091129 . [Q92823-1 ]
    ENST00000425651 ; ENSP00000401244 ; ENSG00000091129 . [Q92823-1 ]
    GeneIDi 4897.
    KEGGi hsa:4897.
    UCSCi uc003vfc.3. human. [Q92823-4 ]
    uc003vfe.3. human. [Q92823-3 ]
    uc011kmk.2. human. [Q92823-1 ]

    Organism-specific databases

    CTDi 4897.
    GeneCardsi GC07M107788.
    HGNCi HGNC:7994. NRCAM.
    HPAi HPA012606.
    MIMi 601581. gene.
    neXtProti NX_Q92823.
    PharmGKBi PA31773.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG293951.
    HOGENOMi HOG000231380.
    HOVERGENi HBG000144.
    KOi K06756.
    OMAi YANISWE.
    OrthoDBi EOG7R56RM.
    PhylomeDBi Q92823.
    TreeFami TF351098.

    Enzyme and pathway databases

    Reactomei REACT_22266. Interaction between L1 and Ankyrins.
    REACT_22312. Neurofascin interactions.
    REACT_22329. NrCAM interactions.

    Miscellaneous databases

    ChiTaRSi NRCAM. human.
    EvolutionaryTracei Q92823.
    GeneWikii NRCAM.
    GenomeRNAii 4897.
    NextBioi 18839.
    PROi Q92823.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92823.
    Bgeei Q92823.
    CleanExi HS_NRCAM.
    Genevestigatori Q92823.

    Family and domain databases

    Gene3Di 2.60.40.10. 11 hits.
    InterProi IPR003961. Fibronectin_type3.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003006. Ig/MHC_CS.
    IPR013098. Ig_I-set.
    IPR003599. Ig_sub.
    IPR003598. Ig_sub2.
    IPR026966. Neurofascin/L1/NrCAM_C.
    [Graphical view ]
    Pfami PF13882. Bravo_FIGEY. 1 hit.
    PF00041. fn3. 5 hits.
    PF07679. I-set. 4 hits.
    [Graphical view ]
    SMARTi SM00060. FN3. 5 hits.
    SM00409. IG. 3 hits.
    SM00408. IGc2. 3 hits.
    [Graphical view ]
    SUPFAMi SSF49265. SSF49265. 3 hits.
    PROSITEi PS50853. FN3. 5 hits.
    PS50835. IG_LIKE. 6 hits.
    PS00290. IG_MHC. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31."
      Lane R.P., Chen X.-N., Yamakawa K., Vielmetter J., Korenberg J.R., Dreyer W.J.
      Genomics 35:456-465(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
      Tissue: Brain.
    2. "The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily."
      Dry K., Kenwrick S., Rosenthal A., Platzer M.
      Gene 273:115-122(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 5).
    3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-545.
      Tissue: Brain.
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
      Tissue: Amygdala.
    5. "The DNA sequence of human chromosome 7."
      Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
      , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
      Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "Human chromosome 7: DNA sequence and biology."
      Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
      , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
      Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-545.
    9. "Temporal and spatial regulation of alternative splicing for human NrCAM in neural and non neural tissues."
      Wang B., Williams H., Du J., Terrett J., Kenwricl S.
      Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-1304 (ISOFORM 1).
      Tissue: Brain.
    10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
      Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
      J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
      Tissue: Plasma.
    11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
      Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
      J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
      Tissue: Liver.
    12. Cited for: GLYCOSYLATION AT ASN-858.
    13. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
      Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
      J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH MYOC.
    14. "Solution structure of the first fibronectin type III domain of human KIAA0343 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2003) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 638-751.
    15. "Solution structure of the third fibronectin III domain of human KIAA0343 protein."
      RIKEN structural genomics initiative (RSGI)
      Submitted (NOV-2003) to the PDB data bank
      Cited for: STRUCTURE BY NMR OF 838-950.
    16. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-1093 AND VAL-1116.

    Entry informationi

    Entry nameiNRCAM_HUMAN
    AccessioniPrimary (citable) accession number: Q92823
    Secondary accession number(s): A4D0S3
    , E9PDA4, O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2003
    Last sequence update: November 25, 2008
    Last modified: October 1, 2014
    This is version 142 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 7
      Human chromosome 7: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3