Q92823 (NRCAM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neuronal cell adhesion molecule
Short name=Nr-CAM

Alternative name(s):
Neuronal surface protein Bravo
Short name=hBravo
NgCAM-related cell adhesion molecule
Short name=Ng-CAM-related

Gene names

Name:	NRCAM
Synonyms:	KIAA0343

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	1304 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier By similarity.
Subunit structure	Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin By similarity.
Subcellular location	Cell membrane; Single-pass type I membrane protein Potential.
Tissue specificity	Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.
Sequence similarities	Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family. Contains 5 fibronectin type-III domains. Contains 6 Ig-like C2-type (immunoglobulin-like) domains.
Sequence caution	The sequence AAC50765.1 differs from that shown. Reason: Erroneous initiation. The sequence BAA20801.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Cell adhesion
Cellular component	Cell membrane Membrane
Coding sequence diversity	Alternative splicing Polymorphism
Domain	Immunoglobulin domain Repeat Signal Transmembrane Transmembrane helix
PTM	Disulfide bond Glycoprotein Phosphoprotein
Technical term	3D-structure Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	angiogenesis Inferred from expression pattern PubMed 11866539. Source: UniProtKB axon guidance Traceable author statement. Source: Reactome axonal fasciculation Non-traceable author statement Ref.1. Source: UniProtKB cell-cell adhesion Non-traceable author statement Ref.1. Source: UniProtKB central nervous system development Non-traceable author statement Ref.1. Source: UniProtKB clustering of voltage-gated sodium channels Inferred from direct assay PubMed 14602817. Source: UniProtKB neuron migration Non-traceable author statement Ref.2. Source: UniProtKB neuronal action potential propagation Inferred from electronic annotation. Source: Compara positive regulation of neuron differentiation Non-traceable author statement Ref.1. Source: UniProtKB protein localization Inferred from electronic annotation. Source: Compara regulation of axon extension Non-traceable author statement Ref.1. Source: UniProtKB retinal ganglion cell axon guidance Inferred from electronic annotation. Source: Compara synapse assembly Traceable author statement Ref.1. Source: UniProtKB
Cellular_component	axon initial segment Inferred from sequence or structural similarity. Source: BHF-UCL external side of plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB integral to plasma membrane Non-traceable author statement Ref.1. Source: UniProtKB synapse Inferred from electronic annotation. Source: Compara
Molecular_function	ankyrin binding Inferred from direct assay PubMed 14602817. Source: UniProtKB
Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92823-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92823-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1236: SDAEDHKPLKK → RLFSFVSSASF
     1237-1304: Missing.

Isoform 3 (identifier: Q92823-3)

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1051-1155: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q92823-4)

The sequence of this isoform differs from the canonical sequence as follows:
     35-40: Missing.
     635-644: Missing.
     1051-1155: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q92823-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: Y → YRSLE

Isoform 6 (identifier: Q92823-6)

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1063-1155: Missing.

Note: No experimental confirmation available.

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 24

24

Potential

Chain

25 – 1304

1280

Neuronal cell adhesion molecule

PRO_0000015057

Regions

Topological domain

25 – 1167

1143

Extracellular Potential

Transmembrane

1168 – 1190

23

Helical; Potential

Topological domain

1191 – 1304

114

Cytoplasmic Potential

Domain

46 – 134

89

Ig-like 1

Domain

141 – 235

95

Ig-like 2

Domain

267 – 356

90

Ig-like 3

Domain

361 – 448

88

Ig-like 4

Domain

454 – 541

88

Ig-like 5

Domain

545 – 632

88

Ig-like 6

Domain

647 – 739

93

Fibronectin type-III 1

Domain

746 – 840

95

Fibronectin type-III 2

Domain

845 – 947

103

Fibronectin type-III 3

Domain

952 – 1046

95

Fibronectin type-III 4

Domain

1061 – 1153

93

Fibronectin type-III 5

Amino acid modifications

Modified residue

427

1

Phosphoserine By similarity

Modified residue

1226

1

Phosphoserine By similarity

Modified residue

1295

1

Phosphoserine By similarity

Glycosylation

83

1

N-linked (GlcNAc...) Potential

Glycosylation

223

1

N-linked (GlcNAc...) Potential

Glycosylation

245

1

N-linked (GlcNAc...) Potential

Glycosylation

251

1

N-linked (GlcNAc...) Potential

Glycosylation

276

1

N-linked (GlcNAc...) Ref.10 Ref.11

Glycosylation

314

1

N-linked (GlcNAc...) Potential

Glycosylation

433

1

N-linked (GlcNAc...) Potential

Glycosylation

507

1

N-linked (GlcNAc...) Potential

Glycosylation

619

1

N-linked (GlcNAc...) Potential

Glycosylation

716

1

N-linked (GlcNAc...) Potential

Glycosylation

802

1

N-linked (GlcNAc...) Potential

Glycosylation

858

1

N-linked (GlcNAc...) Potential

Glycosylation

993

1

N-linked (GlcNAc...) Potential

Glycosylation

1009

1

N-linked (GlcNAc...) Potential

Glycosylation

1019

1

N-linked (GlcNAc...) Potential

Glycosylation

1072

1

N-linked (GlcNAc...) Potential

Glycosylation

1083

1

N-linked (GlcNAc...) Potential

Glycosylation

1115

1

N-linked (GlcNAc...) Potential

Disulfide bond

68 ↔ 123

Potential

Disulfide bond

167 ↔ 218

Potential

Disulfide bond

292 ↔ 340

Potential

Disulfide bond

382 ↔ 432

Potential

Disulfide bond

476 ↔ 525

Potential

Disulfide bond

567 ↔ 616

Potential

Natural variations

Alternative sequence

35 – 40

6

Missing in isoform 4.

VSP_007837

Alternative sequence

241 – 259

19

Missing in isoform 3 and isoform 6.

VSP_007838

Alternative sequence

635 – 644

10

Missing in isoform 4.

VSP_007839

Alternative sequence

1051 – 1155

105

Missing in isoform 3 and isoform 4.

VSP_007840

Alternative sequence

1063 – 1155

93

Missing in isoform 6.

VSP_045040

Alternative sequence

1225

1

Y → YRSLE in isoform 5.

VSP_007843

Alternative sequence

1226 – 1236

11

SDAEDHKPLKK → RLFSFVSSASF in isoform 2.

VSP_007841

Alternative sequence

1237 – 1304

68

Missing in isoform 2.

VSP_007842

Natural variant

545

1

P → A. Ref.3 Ref.6 Ref.7 Ref.8
Corresponds to variant rs6958498 [ dbSNP | Ensembl ].

VAR_047550

Natural variant

1093

1

H → P in a breast cancer sample; somatic mutation. Ref.14

VAR_035528

Natural variant

1116

1

G → V in a breast cancer sample; somatic mutation. Ref.14

VAR_035529

Experimental info

Sequence conflict

487

1

E → Q in CAA04507. Ref.9

Sequence conflict

512

1

I → IKDATWIVKEI in AAC50765. Ref.1

Sequence conflict

541 – 550

10

Missing in AAC50765. Ref.1

Sequence conflict

651

1

F → L in CAA04507. Ref.9

Sequence conflict

679 – 682

4

KFII → TIHD in CAA04507. Ref.9

Sequence conflict

710

1

K → N in BAA20801. Ref.3

Sequence conflict

764

1

V → E in AAC50765. Ref.1

Sequence conflict

775

1

S → F in CAA04507. Ref.9

Sequence conflict

790

1

D → V in CAA04507. Ref.9

Sequence conflict

921

1

F → L in CAD97960. Ref.4

Sequence conflict

954

1

A → V in CAA04507. Ref.9

Sequence conflict

994

1

S → N in CAA04507. Ref.9

Sequence conflict

1008

1

A → T in CAD97960. Ref.4

Sequence conflict

1021

1

S → T in CAA04507. Ref.9

Sequence conflict

1068

1

P → T in AAC50765. Ref.1

Sequence conflict

1093 – 1094

2

HV → YA in CAA04507. Ref.9

Sequence conflict

1134

1

V → F in CAA04507. Ref.9

Sequence conflict

1141 – 1143

3

DSG → GPR in CAA04507. Ref.9

Sequence conflict

1149

1

D → G in CAA04507. Ref.9

Sequence conflict

1256

1

V → L in CAA04507. Ref.9

Secondary structure

1

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

.

1304

Helix Strand Turn

Details...

Beta strand

651 – 656

6

Beta strand

659 – 661

3

Beta strand

663 – 668

6

Beta strand

677 – 686

10

Turn

687 – 689

3

Beta strand

694 – 703

10

Beta strand

706 – 709

4

Beta strand

720 – 727

8

Beta strand

853 – 858

6

Beta strand

861 – 865

5

Helix

871 – 874

4

Beta strand

878 – 889

12

Beta strand

901 – 909

9

Beta strand

911 – 917

7

Beta strand

923 – 934

12

Beta strand

936 – 939

4

Beta strand

943 – 946

4

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified November 25, 2008. Version 3. Checksum: 1F2698BC7DB5C363	FASTA	1,304	143,890
	10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 250 260 270 280 290 300 VDELNDTIAA NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP 310 320 330 340 350 360 IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH HTISVRVKAA 370 380 390 400 410 420 PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP IEIAPDDPSR KIDGDTIIFS 430 440 450 460 470 480 NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTPA NTLYQVIANR PALLDCAFFG 490 500 510 520 530 540 SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL 550 560 570 580 590 600 EIKDPTWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH 610 620 630 640 650 660 LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP FDLELTDQLD 670 680 690 700 710 720 KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV SGTQTTAQLK LSPYVNYSFR 730 740 750 760 770 780 VMAVNSIGKS LPSEASEQYL TKASEPDKNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL 790 800 810 820 830 840 QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS 850 860 870 880 890 900 GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE 910 920 930 940 950 960 KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI 970 980 990 1000 1010 1020 VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF 1030 1040 1050 1060 1070 1080 STRYKFYFYA QTSAGSGSQI TEEAVTTVDE AGILPPDVGA GKVQAVNPRI SNLTAAAAET 1090 1100 1110 1120 1130 1140 YANISWEYEG PEHVNFYVEY GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG 1150 1160 1170 1180 1190 1200 DSGFVSSEDV FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV 1210 1220 1230 1240 1250 1260 KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED SDDSLVDYGE 1270 1280 1290 1300 GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM NSFV
	Isoform 2 [UniParc]. Checksum: 0C21479D02E6CCE2	FASTA	1,236	136,614
	10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 250 260 270 280 290 300 VDELNDTIAA NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP 310 320 330 340 350 360 IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH HTISVRVKAA 370 380 390 400 410 420 PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP IEIAPDDPSR KIDGDTIIFS 430 440 450 460 470 480 NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTPA NTLYQVIANR PALLDCAFFG 490 500 510 520 530 540 SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL 550 560 570 580 590 600 EIKDPTWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH 610 620 630 640 650 660 LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP FDLELTDQLD 670 680 690 700 710 720 KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV SGTQTTAQLK LSPYVNYSFR 730 740 750 760 770 780 VMAVNSIGKS LPSEASEQYL TKASEPDKNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL 790 800 810 820 830 840 QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS 850 860 870 880 890 900 GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE 910 920 930 940 950 960 KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI 970 980 990 1000 1010 1020 VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF 1030 1040 1050 1060 1070 1080 STRYKFYFYA QTSAGSGSQI TEEAVTTVDE AGILPPDVGA GKVQAVNPRI SNLTAAAAET 1090 1100 1110 1120 1130 1140 YANISWEYEG PEHVNFYVEY GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG 1150 1160 1170 1180 1190 1200 DSGFVSSEDV FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV 1210 1220 1230 KEKEDAHADP EIQPMKEDDG TFGEYRLFSF VSSASF
	Isoform 3 [UniParc]. Checksum: DF33D4380A609B75	FASTA	1,180	130,668
	10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 250 260 270 280 290 300 AKSSRERPPT FLTPEGNASN KEELRGNVLS LECIAEGLPT PIIYWAKEDG MLPKNRTVYK 310 320 330 340 350 360 NFEKTLQIIH VSEADSGNYQ CIAKNALGAI HHTISVRVKA APYWITAPQN LVLSPGEDGT 370 380 390 400 410 420 LICRANGNPK PRISWLTNGV PIEIAPDDPS RKIDGDTIIF SNVQERSSAV YQCNASNEYG 430 440 450 460 470 480 YLLANAFVNV LAEPPRILTP ANTLYQVIAN RPALLDCAFF GSPLPTIEWF KGAKGSALHE 490 500 510 520 530 540 DIYVLHENGT LEIPVAQKDS TGTYTCVARN KLGMAKNEVH LEIKDPTWIV KQPEYAVVQR 550 560 570 580 590 600 GSMVSFECKV KHDHTLSLTV LWLKDNRELP SDERFTVDKD HLVVADVSDD DSGTYTCVAN 610 620 630 640 650 660 TTLDSVSASA VLSVVAPTPT PAPVYDVPNP PFDLELTDQL DKSVQLSWTP GDDNNSPITK 670 680 690 700 710 720 FIIEYEDAMH KPGLWHHQTE VSGTQTTAQL KLSPYVNYSF RVMAVNSIGK SLPSEASEQY 730 740 750 760 770 780 LTKASEPDKN PTAVEGLGSE PDNLVITWKP LNGFESNGPG LQYKVSWRQK DGDDEWTSVV 790 800 810 820 830 840 VANVSKYIVS GTPTFVPYLI KVQALNDMGF APEPAVVMGH SGEDLPMVAP GNVRVNVVNS 850 860 870 880 890 900 TLAEVHWDPV PLKSIRGHLQ GYRIYYWKTQ SSSKRNRRHI EKKILTFQGS KTHGMLPGLE 910 920 930 940 950 960 PFSHYTLNVR VVNGKGEGPA SPDRVFNTPE GVPSAPSSLK IVNPTLDSLT LEWDPPSHPN 970 980 990 1000 1010 1020 GILTEYTLKY QPINSTHELG PLVDLKIPAN KTRWTLKNLN FSTRYKFYFY AQTSAGSGSQ 1030 1040 1050 1060 1070 1080 ITEEAVTTVD EAMASRQVDI ATQGWFIGLM CAVALLILIL LIVCFIRRNK GGKYPVKEKE 1090 1100 1110 1120 1130 1140 DAHADPEIQP MKEDDGTFGE YSDAEDHKPL KKGSRTPSDR TVKKEDSDDS LVDYGEGVNG 1150 1160 1170 1180 QFNEDGSFIG QYSGKKEKEP AEGNESSEAP SPVNAMNSFV
	Isoform 4 [UniParc]. Checksum: FEF6A39C50DE9664	FASTA	1,183	131,046
	10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDLVQPP TITQQSPKDY IIDPRENIVI 70 80 90 100 110 120 QCEAKGKPPP SFSWTRNGTH FDIDKDPLVT MKPGTGTLII NIMSEGKAET YEGVYQCTAR 130 140 150 160 170 180 NERGAAVSNN IVVRPSRSPL WTKEKLEPIT LQSGQSLVLP CRPPIGLPPP IIFWMDNSFQ 190 200 210 220 230 240 RLPQSERVSQ GLNGDLYFSN VLPEDTREDY ICYARFNHTQ TIQQKQPISV KVISVDELND 250 260 270 280 290 300 TIAANLSDTE FYGAKSSRER PPTFLTPEGN ASNKEELRGN VLSLECIAEG LPTPIIYWAK 310 320 330 340 350 360 EDGMLPKNRT VYKNFEKTLQ IIHVSEADSG NYQCIAKNAL GAIHHTISVR VKAAPYWITA 370 380 390 400 410 420 PQNLVLSPGE DGTLICRANG NPKPRISWLT NGVPIEIAPD DPSRKIDGDT IIFSNVQERS 430 440 450 460 470 480 SAVYQCNASN EYGYLLANAF VNVLAEPPRI LTPANTLYQV IANRPALLDC AFFGSPLPTI 490 500 510 520 530 540 EWFKGAKGSA LHEDIYVLHE NGTLEIPVAQ KDSTGTYTCV ARNKLGMAKN EVHLEIKDPT 550 560 570 580 590 600 WIVKQPEYAV VQRGSMVSFE CKVKHDHTLS LTVLWLKDNR ELPSDERFTV DKDHLVVADV 610 620 630 640 650 660 SDDDSGTYTC VANTTLDSVS ASAVLSVVDV PNPPFDLELT DQLDKSVQLS WTPGDDNNSP 670 680 690 700 710 720 ITKFIIEYED AMHKPGLWHH QTEVSGTQTT AQLKLSPYVN YSFRVMAVNS IGKSLPSEAS 730 740 750 760 770 780 EQYLTKASEP DKNPTAVEGL GSEPDNLVIT WKPLNGFESN GPGLQYKVSW RQKDGDDEWT 790 800 810 820 830 840 SVVVANVSKY IVSGTPTFVP YLIKVQALND MGFAPEPAVV MGHSGEDLPM VAPGNVRVNV 850 860 870 880 890 900 VNSTLAEVHW DPVPLKSIRG HLQGYRIYYW KTQSSSKRNR RHIEKKILTF QGSKTHGMLP 910 920 930 940 950 960 GLEPFSHYTL NVRVVNGKGE GPASPDRVFN TPEGVPSAPS SLKIVNPTLD SLTLEWDPPS 970 980 990 1000 1010 1020 HPNGILTEYT LKYQPINSTH ELGPLVDLKI PANKTRWTLK NLNFSTRYKF YFYAQTSAGS 1030 1040 1050 1060 1070 1080 GSQITEEAVT TVDEAMASRQ VDIATQGWFI GLMCAVALLI LILLIVCFIR RNKGGKYPVK 1090 1100 1110 1120 1130 1140 EKEDAHADPE IQPMKEDDGT FGEYSDAEDH KPLKKGSRTP SDRTVKKEDS DDSLVDYGEG 1150 1160 1170 1180 VNGQFNEDGS FIGQYSGKKE KEPAEGNESS EAPSPVNAMN SFV
	Isoform 5 [UniParc]. Checksum: 7019F3533A0F445E	FASTA	1,308	144,375
	10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 250 260 270 280 290 300 VDELNDTIAA NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP 310 320 330 340 350 360 IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH HTISVRVKAA 370 380 390 400 410 420 PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP IEIAPDDPSR KIDGDTIIFS 430 440 450 460 470 480 NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTPA NTLYQVIANR PALLDCAFFG 490 500 510 520 530 540 SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL 550 560 570 580 590 600 EIKDPTWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH 610 620 630 640 650 660 LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP FDLELTDQLD 670 680 690 700 710 720 KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV SGTQTTAQLK LSPYVNYSFR 730 740 750 760 770 780 VMAVNSIGKS LPSEASEQYL TKASEPDKNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL 790 800 810 820 830 840 QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS 850 860 870 880 890 900 GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE 910 920 930 940 950 960 KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI 970 980 990 1000 1010 1020 VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF 1030 1040 1050 1060 1070 1080 STRYKFYFYA QTSAGSGSQI TEEAVTTVDE AGILPPDVGA GKVQAVNPRI SNLTAAAAET 1090 1100 1110 1120 1130 1140 YANISWEYEG PEHVNFYVEY GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG 1150 1160 1170 1180 1190 1200 DSGFVSSEDV FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV 1210 1220 1230 1240 1250 1260 KEKEDAHADP EIQPMKEDDG TFGEYRSLES DAEDHKPLKK GSRTPSDRTV KKEDSDDSLV 1270 1280 1290 1300 DYGEGVNGQF NEDGSFIGQY SGKKEKEPAE GNESSEAPSP VNAMNSFV
	Isoform 6 [UniParc]. Checksum: 0D9E6E1CDB666115	FASTA	1,192	131,744
	10 20 30 40 50 60 MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 70 80 90 100 110 120 RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 130 140 150 160 170 180 YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 190 200 210 220 230 240 MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 250 260 270 280 290 300 AKSSRERPPT FLTPEGNASN KEELRGNVLS LECIAEGLPT PIIYWAKEDG MLPKNRTVYK 310 320 330 340 350 360 NFEKTLQIIH VSEADSGNYQ CIAKNALGAI HHTISVRVKA APYWITAPQN LVLSPGEDGT 370 380 390 400 410 420 LICRANGNPK PRISWLTNGV PIEIAPDDPS RKIDGDTIIF SNVQERSSAV YQCNASNEYG 430 440 450 460 470 480 YLLANAFVNV LAEPPRILTP ANTLYQVIAN RPALLDCAFF GSPLPTIEWF KGAKGSALHE 490 500 510 520 530 540 DIYVLHENGT LEIPVAQKDS TGTYTCVARN KLGMAKNEVH LEIKDPTWIV KQPEYAVVQR 550 560 570 580 590 600 GSMVSFECKV KHDHTLSLTV LWLKDNRELP SDERFTVDKD HLVVADVSDD DSGTYTCVAN 610 620 630 640 650 660 TTLDSVSASA VLSVVAPTPT PAPVYDVPNP PFDLELTDQL DKSVQLSWTP GDDNNSPITK 670 680 690 700 710 720 FIIEYEDAMH KPGLWHHQTE VSGTQTTAQL KLSPYVNYSF RVMAVNSIGK SLPSEASEQY 730 740 750 760 770 780 LTKASEPDKN PTAVEGLGSE PDNLVITWKP LNGFESNGPG LQYKVSWRQK DGDDEWTSVV 790 800 810 820 830 840 VANVSKYIVS GTPTFVPYLI KVQALNDMGF APEPAVVMGH SGEDLPMVAP GNVRVNVVNS 850 860 870 880 890 900 TLAEVHWDPV PLKSIRGHLQ GYRIYYWKTQ SSSKRNRRHI EKKILTFQGS KTHGMLPGLE 910 920 930 940 950 960 PFSHYTLNVR VVNGKGEGPA SPDRVFNTPE GVPSAPSSLK IVNPTLDSLT LEWDPPSHPN 970 980 990 1000 1010 1020 GILTEYTLKY QPINSTHELG PLVDLKIPAN KTRWTLKNLN FSTRYKFYFY AQTSAGSGSQ 1030 1040 1050 1060 1070 1080 ITEEAVTTVD EAGILPPDVG AGKAMASRQV DIATQGWFIG LMCAVALLIL ILLIVCFIRR 1090 1100 1110 1120 1130 1140 NKGGKYPVKE KEDAHADPEI QPMKEDDGTF GEYSDAEDHK PLKKGSRTPS DRTVKKEDSD 1150 1160 1170 1180 1190 DSLVDYGEGV NGQFNEDGSF IGQYSGKKEK EPAEGNESSE APSPVNAMNS FV

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31." Lane R.P., Chen X.-N., Yamakawa K., Vielmetter J., Korenberg J.R., Dreyer W.J. Genomics 35:456-465(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1). Tissue: Brain.
[2]	"The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily." Dry K., Kenwrick S., Rosenthal A., Platzer M. Gene 273:115-122(2001) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 5).
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-545. Tissue: Brain.
[4]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4). Tissue: Amygdala.
[5]	"The DNA sequence of human chromosome 7." Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K. Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-545.
[9]	"Temporal and spatial regulation of alternative splicing for human NrCAM in neural and non neural tissues." Wang B., Williams H., Du J., Terrett J., Kenwricl S. Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-1304 (ISOFORM 1). Tissue: Brain.
[10]	"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry." Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D. J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276, MASS SPECTROMETRY. Tissue: Plasma.
[11]	"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry." Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H. J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract] Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276, MASS SPECTROMETRY. Tissue: Liver.
[12]	"Solution structure of the first fibronectin type III domain of human KIAA0343 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2003) to the PDB data bank Cited for: STRUCTURE BY NMR OF 638-751.
[13]	"Solution structure of the third fibronectin III domain of human KIAA0343 protein." RIKEN structural genomics initiative (RSGI) Submitted (NOV-2003) to the PDB data bank Cited for: STRUCTURE BY NMR OF 838-950.
[14]	"The consensus coding sequences of human breast and colorectal cancers." Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E. Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract] Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-1093 AND VAL-1116.
+	Additional computationally mapped references.

Web resources

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Cross-references

Sequence databases

EMBL
GenBank
DDBJ

U55258 Genomic DNA. Translation: AAC50765.1. Different initiation.
AF172277 Genomic DNA. Translation: AAF22282.1.
AF172277 Genomic DNA. Translation: AAF22283.1.
AB002341 mRNA. Translation: BAA20801.2. Different initiation.
BX538010 mRNA. Translation: CAD97960.1.
AC005683 Genomic DNA. No translation available.
AC007567 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24386.1.
CH471070 Genomic DNA. Translation: EAW83429.1.
BC115736 mRNA. Translation: AAI15737.1.
AJ001054 mRNA. Translation: CAA04504.1.
AJ001057 mRNA. Translation: CAA04507.1.

IPI

IPI00333776.
IPI00333777.
IPI00333778.
IPI00415032.
IPI00873446.
IPI00883753.

RefSeq

NP_001032209.1. NM_001037132.2.
NP_001180511.1. NM_001193582.1.
NP_001180512.1. NM_001193583.1.
NP_001180513.1. NM_001193584.1.
NP_005001.3. NM_005010.4.

UniGene

Hs.21422.

3D structure databases

PDBe
RCSB PDB
PDBj

Entry	Method	Resolution (Å)	Chain	Positions	PDBsum
1UEN	NMR	-	A	838-950	[»]
1UEY	NMR	-	A	638-751	[»]

ProteinModelPortal

Q92823.

ModBase

Search...

Protein-protein interaction databases

IntAct

Q92823. 4 interactions.

STRING

9606.ENSP00000368314.

PTM databases

PhosphoSite

Q92823.

Polymorphism databases

DMDM

215274127.

Proteomic databases

PaxDb

Q92823.

PRIDE

Q92823.

Protocols and materials databases

StructuralBiologyKnowledgebase

Search...

Genome annotation databases

Ensembl

ENST00000351718; ENSP00000325269; ENSG00000091129.
ENST00000379024; ENSP00000368310; ENSG00000091129.
ENST00000379028; ENSP00000368314; ENSG00000091129.
ENST00000425651; ENSP00000401244; ENSG00000091129.

GeneID

4897.

KEGG

hsa:4897.

UCSC

uc003vfc.3. human.
uc003vfe.3. human.
uc011kmk.2. human.

Organism-specific databases

CTD

4897.

GeneCards

GC07M107788.

HGNC

HGNC:7994. NRCAM.

HPA

HPA012606.

MIM

601581. gene.

neXtProt

NX_Q92823.

PharmGKB

PA31773.

HUGE

Search...

GenAtlas

Search...

Phylogenomic databases

eggNOG

NOG293951.

HOGENOM

HOG000231380.

HOVERGEN

HBG000144.

KO

K06756.

Enzyme and pathway databases

Reactome

REACT_111045. Developmental Biology.

Gene expression databases

ArrayExpress

Q92823.

Bgee

Q92823.

CleanEx

HS_NRCAM.

Genevestigator

Q92823.

GermOnline

ENSG00000091129. Homo sapiens.

Family and domain databases

Gene3D

2.60.40.10. 11 hits.

InterPro

IPR026966. Fibronectin_III_C.
IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
[Graphical view]

Pfam

PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 3 hits.
[Graphical view]

SMART

SM00060. FN3. 5 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]

SUPFAM

SSF49265. FN_III-like. 5 hits.

PROSITE

PS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

ProtoNet

Search...

Other

ChiTaRS

NRCAM. human.

EvolutionaryTrace

Q92823.

GenomeRNAi

4897.

NextBio

18839.

SOURCE

Search...

Entry information

Entry name

NRCAM_HUMAN

Accession

Primary (citable) accession number: Q92823
Secondary accession number(s): A4D0S3 , E9PDA4, O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 19, 2003
Last sequence update:	November 25, 2008
Last modified:	May 1, 2013
This is version 127 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.