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Q92823

- NRCAM_HUMAN

UniProt

Q92823 - NRCAM_HUMAN

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Protein

Neuronal cell adhesion molecule

Gene

NRCAM

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier (By similarity).By similarity

GO - Molecular functioni

  1. ankyrin binding Source: UniProtKB

GO - Biological processi

  1. angiogenesis Source: UniProtKB
  2. axonal fasciculation Source: UniProtKB
  3. axon guidance Source: Reactome
  4. axonogenesis Source: UniProtKB
  5. central nervous system development Source: UniProtKB
  6. clustering of voltage-gated sodium channels Source: UniProtKB
  7. heterotypic cell-cell adhesion Source: Ensembl
  8. neuronal action potential propagation Source: Ensembl
  9. neuron migration Source: UniProtKB
  10. positive regulation of neuron differentiation Source: UniProtKB
  11. protein localization Source: Ensembl
  12. regulation of axon extension Source: UniProtKB
  13. retinal ganglion cell axon guidance Source: Ensembl
  14. single organismal cell-cell adhesion Source: UniProtKB
  15. synapse assembly Source: UniProtKB
Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_22266. Interaction between L1 and Ankyrins.
REACT_22312. Neurofascin interactions.
REACT_22329. NrCAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuronal cell adhesion molecule
Short name:
Nr-CAM
Alternative name(s):
Neuronal surface protein Bravo
Short name:
hBravo
NgCAM-related cell adhesion molecule
Short name:
Ng-CAM-related
Gene namesi
Name:NRCAM
Synonyms:KIAA0343
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 7

Organism-specific databases

HGNCiHGNC:7994. NRCAM.

Subcellular locationi

GO - Cellular componenti

  1. axon initial segment Source: BHF-UCL
  2. external side of plasma membrane Source: UniProtKB
  3. integral component of plasma membrane Source: UniProtKB
  4. neuron projection Source: UniProtKB
  5. plasma membrane Source: Reactome
  6. synapse Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA31773.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2424Sequence AnalysisAdd
BLAST
Chaini25 – 13041280Neuronal cell adhesion moleculePRO_0000015057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi68 ↔ 123PROSITE-ProRule annotation
Glycosylationi83 – 831N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi167 ↔ 218PROSITE-ProRule annotation
Glycosylationi223 – 2231N-linked (GlcNAc...)Sequence Analysis
Glycosylationi245 – 2451N-linked (GlcNAc...)Sequence Analysis
Glycosylationi251 – 2511N-linked (GlcNAc...)Sequence Analysis
Glycosylationi276 – 2761N-linked (GlcNAc...)2 Publications
Disulfide bondi292 ↔ 340PROSITE-ProRule annotation
Glycosylationi314 – 3141N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi382 ↔ 432PROSITE-ProRule annotation
Glycosylationi433 – 4331N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi476 ↔ 525PROSITE-ProRule annotation
Glycosylationi507 – 5071N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi567 ↔ 616PROSITE-ProRule annotation
Glycosylationi619 – 6191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi716 – 7161N-linked (GlcNAc...)Sequence Analysis
Glycosylationi802 – 8021N-linked (GlcNAc...)Sequence Analysis
Glycosylationi858 – 8581N-linked (GlcNAc...) (complex)1 Publication
Glycosylationi993 – 9931N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1009 – 10091N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1019 – 10191N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1072 – 10721N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1083 – 10831N-linked (GlcNAc...)Sequence Analysis
Glycosylationi1115 – 11151N-linked (GlcNAc...)Sequence Analysis
Modified residuei1271 – 12711PhosphoserineBy similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92823.
PaxDbiQ92823.
PRIDEiQ92823.

PTM databases

PhosphoSiteiQ92823.

Expressioni

Tissue specificityi

Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

Gene expression databases

BgeeiQ92823.
CleanExiHS_NRCAM.
ExpressionAtlasiQ92823. baseline and differential.
GenevestigatoriQ92823.

Organism-specific databases

HPAiHPA012606.

Interactioni

Subunit structurei

Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin (By similarity). Interacts with MYOC.By similarity1 Publication

Protein-protein interaction databases

BioGridi110953. 7 interactions.
IntActiQ92823. 5 interactions.
STRINGi9606.ENSP00000368314.

Structurei

Secondary structure

1
1304
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi651 – 6566
Beta strandi659 – 6613
Beta strandi663 – 6686
Beta strandi677 – 68610
Turni687 – 6893
Beta strandi694 – 70310
Beta strandi706 – 7094
Beta strandi720 – 7278
Beta strandi853 – 8586
Beta strandi861 – 8655
Helixi871 – 8744
Beta strandi878 – 88912
Beta strandi901 – 9099
Beta strandi911 – 9177
Beta strandi923 – 93412
Beta strandi936 – 9394
Beta strandi943 – 9464

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1UENNMR-A839-950[»]
1UEYNMR-A638-751[»]
ProteinModelPortaliQ92823.
SMRiQ92823. Positions 42-835, 842-1143.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92823.

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini25 – 11671143ExtracellularSequence AnalysisAdd
BLAST
Topological domaini1191 – 1304114CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei1168 – 119023HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini46 – 13489Ig-like 1Add
BLAST
Domaini141 – 23595Ig-like 2Add
BLAST
Domaini267 – 35690Ig-like 3Add
BLAST
Domaini361 – 44888Ig-like 4Add
BLAST
Domaini454 – 54188Ig-like 5Add
BLAST
Domaini545 – 63288Ig-like 6Add
BLAST
Domaini649 – 74496Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini746 – 84398Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini848 – 950103Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini954 – 105198Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini1064 – 115693Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG293951.
GeneTreeiENSGT00760000118840.
HOGENOMiHOG000231380.
HOVERGENiHBG000144.
InParanoidiQ92823.
KOiK06756.
OMAiYANISWE.
OrthoDBiEOG7R56RM.
PhylomeDBiQ92823.
TreeFamiTF351098.

Family and domain databases

Gene3Di2.60.40.10. 11 hits.
InterProiIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamiPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTiSM00060. FN3. 5 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]

Sequences (6)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 6 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92823-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ
60 70 80 90 100
QSPKDYIIDP RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG
110 120 130 140 150
TGTLIINIMS EGKAETYEGV YQCTARNERG AAVSNNIVVR PSRSPLWTKE
160 170 180 190 200
KLEPITLQSG QSLVLPCRPP IGLPPPIIFW MDNSFQRLPQ SERVSQGLNG
210 220 230 240 250
DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS VDELNDTIAA
260 270 280 290 300
NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP
310 320 330 340 350
IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH
360 370 380 390 400
HTISVRVKAA PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP
410 420 430 440 450
IEIAPDDPSR KIDGDTIIFS NVQERSSAVY QCNASNEYGY LLANAFVNVL
460 470 480 490 500
AEPPRILTPA NTLYQVIANR PALLDCAFFG SPLPTIEWFK GAKGSALHED
510 520 530 540 550
IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL EIKDPTWIVK
560 570 580 590 600
QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH
610 620 630 640 650
LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP
660 670 680 690 700
FDLELTDQLD KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV
710 720 730 740 750
SGTQTTAQLK LSPYVNYSFR VMAVNSIGKS LPSEASEQYL TKASEPDKNP
760 770 780 790 800
TAVEGLGSEP DNLVITWKPL NGFESNGPGL QYKVSWRQKD GDDEWTSVVV
810 820 830 840 850
ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS GEDLPMVAPG
860 870 880 890 900
NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE
910 920 930 940 950
KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG
960 970 980 990 1000
VPSAPSSLKI VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP
1010 1020 1030 1040 1050
LVDLKIPANK TRWTLKNLNF STRYKFYFYA QTSAGSGSQI TEEAVTTVDE
1060 1070 1080 1090 1100
AGILPPDVGA GKVQAVNPRI SNLTAAAAET YANISWEYEG PEHVNFYVEY
1110 1120 1130 1140 1150
GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG DSGFVSSEDV
1160 1170 1180 1190 1200
FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV
1210 1220 1230 1240 1250
KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED
1260 1270 1280 1290 1300
SDDSLVDYGE GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM

NSFV
Length:1,304
Mass (Da):143,890
Last modified:November 25, 2008 - v3
Checksum:i1F2698BC7DB5C363
GO
Isoform 2 (identifier: Q92823-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1236: SDAEDHKPLKK → RLFSFVSSASF
     1237-1304: Missing.

Show »
Length:1,236
Mass (Da):136,614
Checksum:i0C21479D02E6CCE2
GO
Isoform 3 (identifier: Q92823-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1051-1155: Missing.

Note: No experimental confirmation available.

Show »
Length:1,180
Mass (Da):130,668
Checksum:iDF33D4380A609B75
GO
Isoform 4 (identifier: Q92823-4) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     35-40: Missing.
     635-644: Missing.
     1051-1155: Missing.

Note: No experimental confirmation available.

Show »
Length:1,183
Mass (Da):131,046
Checksum:iFEF6A39C50DE9664
GO
Isoform 5 (identifier: Q92823-5) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: Y → YRSLE

Show »
Length:1,308
Mass (Da):144,375
Checksum:i7019F3533A0F445E
GO
Isoform 6 (identifier: Q92823-6) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1063-1155: Missing.

Note: No experimental confirmation available.

Show »
Length:1,192
Mass (Da):131,744
Checksum:i0D9E6E1CDB666115
GO

Sequence cautioni

The sequence AAC50765.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAA20801.2 differs from that shown. Reason: Erroneous initiation.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti487 – 4871E → Q in CAA04507. 1 PublicationCurated
Sequence conflicti512 – 5121I → IKDATWIVKEI in AAC50765. (PubMed:8812479)Curated
Sequence conflicti541 – 55010Missing in AAC50765. (PubMed:8812479)Curated
Sequence conflicti651 – 6511F → L in CAA04507. 1 PublicationCurated
Sequence conflicti679 – 6824KFII → TIHD in CAA04507. 1 PublicationCurated
Sequence conflicti710 – 7101K → N in BAA20801. (PubMed:9205841)Curated
Sequence conflicti764 – 7641V → E in AAC50765. (PubMed:8812479)Curated
Sequence conflicti775 – 7751S → F in CAA04507. 1 PublicationCurated
Sequence conflicti790 – 7901D → V in CAA04507. 1 PublicationCurated
Sequence conflicti921 – 9211F → L in CAD97960. (PubMed:17974005)Curated
Sequence conflicti954 – 9541A → V in CAA04507. 1 PublicationCurated
Sequence conflicti994 – 9941S → N in CAA04507. 1 PublicationCurated
Sequence conflicti1008 – 10081A → T in CAD97960. (PubMed:17974005)Curated
Sequence conflicti1021 – 10211S → T in CAA04507. 1 PublicationCurated
Sequence conflicti1068 – 10681P → T in AAC50765. (PubMed:8812479)Curated
Sequence conflicti1093 – 10942HV → YA in CAA04507. 1 PublicationCurated
Sequence conflicti1134 – 11341V → F in CAA04507. 1 PublicationCurated
Sequence conflicti1141 – 11433DSG → GPR in CAA04507. 1 PublicationCurated
Sequence conflicti1149 – 11491D → G in CAA04507. 1 PublicationCurated
Sequence conflicti1256 – 12561V → L in CAA04507. 1 PublicationCurated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti545 – 5451P → A.4 Publications
Corresponds to variant rs6958498 [ dbSNP | Ensembl ].
VAR_047550
Natural varianti1093 – 10931H → P in a breast cancer sample; somatic mutation. 1 Publication
VAR_035528
Natural varianti1116 – 11161G → V in a breast cancer sample; somatic mutation. 1 Publication
VAR_035529

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei35 – 406Missing in isoform 4. 1 PublicationVSP_007837
Alternative sequencei241 – 25919Missing in isoform 3 and isoform 6. 2 PublicationsVSP_007838Add
BLAST
Alternative sequencei635 – 64410Missing in isoform 4. 1 PublicationVSP_007839
Alternative sequencei1051 – 1155105Missing in isoform 3 and isoform 4. 2 PublicationsVSP_007840Add
BLAST
Alternative sequencei1063 – 115593Missing in isoform 6. 1 PublicationVSP_045040Add
BLAST
Alternative sequencei1225 – 12251Y → YRSLE in isoform 5. CuratedVSP_007843
Alternative sequencei1226 – 123611SDAEDHKPLKK → RLFSFVSSASF in isoform 2. CuratedVSP_007841Add
BLAST
Alternative sequencei1237 – 130468Missing in isoform 2. CuratedVSP_007842Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55258 Genomic DNA. Translation: AAC50765.1. Different initiation.
AF172277 Genomic DNA. Translation: AAF22282.1.
AF172277 Genomic DNA. Translation: AAF22283.1.
AB002341 mRNA. Translation: BAA20801.2. Different initiation.
BX538010 mRNA. Translation: CAD97960.1.
AC005683 Genomic DNA. No translation available.
AC007567 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24386.1.
CH471070 Genomic DNA. Translation: EAW83429.1.
BC115736 mRNA. Translation: AAI15737.1.
AJ001054 mRNA. Translation: CAA04504.1.
AJ001057 mRNA. Translation: CAA04507.1.
CCDSiCCDS47686.1. [Q92823-1]
CCDS55153.1. [Q92823-6]
CCDS5751.1. [Q92823-4]
RefSeqiNP_001032209.1. NM_001037132.2. [Q92823-1]
NP_001180511.1. NM_001193582.1.
NP_001180512.1. NM_001193583.1. [Q92823-6]
NP_001180513.1. NM_001193584.1. [Q92823-3]
NP_005001.3. NM_005010.4. [Q92823-4]
XP_005250430.1. XM_005250373.2. [Q92823-1]
XP_006716066.1. XM_006716003.1. [Q92823-5]
XP_006716067.1. XM_006716004.1. [Q92823-5]
UniGeneiHs.21422.

Genome annotation databases

EnsembliENST00000351718; ENSP00000325269; ENSG00000091129. [Q92823-4]
ENST00000379024; ENSP00000368310; ENSG00000091129. [Q92823-6]
ENST00000379028; ENSP00000368314; ENSG00000091129. [Q92823-1]
ENST00000425651; ENSP00000401244; ENSG00000091129. [Q92823-1]
GeneIDi4897.
KEGGihsa:4897.
UCSCiuc003vfc.3. human. [Q92823-4]
uc003vfe.3. human. [Q92823-3]
uc011kmk.2. human. [Q92823-1]

Polymorphism databases

DMDMi215274127.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U55258 Genomic DNA. Translation: AAC50765.1 . Different initiation.
AF172277 Genomic DNA. Translation: AAF22282.1 .
AF172277 Genomic DNA. Translation: AAF22283.1 .
AB002341 mRNA. Translation: BAA20801.2 . Different initiation.
BX538010 mRNA. Translation: CAD97960.1 .
AC005683 Genomic DNA. No translation available.
AC007567 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24386.1 .
CH471070 Genomic DNA. Translation: EAW83429.1 .
BC115736 mRNA. Translation: AAI15737.1 .
AJ001054 mRNA. Translation: CAA04504.1 .
AJ001057 mRNA. Translation: CAA04507.1 .
CCDSi CCDS47686.1. [Q92823-1 ]
CCDS55153.1. [Q92823-6 ]
CCDS5751.1. [Q92823-4 ]
RefSeqi NP_001032209.1. NM_001037132.2. [Q92823-1 ]
NP_001180511.1. NM_001193582.1.
NP_001180512.1. NM_001193583.1. [Q92823-6 ]
NP_001180513.1. NM_001193584.1. [Q92823-3 ]
NP_005001.3. NM_005010.4. [Q92823-4 ]
XP_005250430.1. XM_005250373.2. [Q92823-1 ]
XP_006716066.1. XM_006716003.1. [Q92823-5 ]
XP_006716067.1. XM_006716004.1. [Q92823-5 ]
UniGenei Hs.21422.

3D structure databases

Select the link destinations:
PDBe
RCSB PDB
PDBj
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
1UEN NMR - A 839-950 [» ]
1UEY NMR - A 638-751 [» ]
ProteinModelPortali Q92823.
SMRi Q92823. Positions 42-835, 842-1143.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110953. 7 interactions.
IntActi Q92823. 5 interactions.
STRINGi 9606.ENSP00000368314.

PTM databases

PhosphoSitei Q92823.

Polymorphism databases

DMDMi 215274127.

Proteomic databases

MaxQBi Q92823.
PaxDbi Q92823.
PRIDEi Q92823.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000351718 ; ENSP00000325269 ; ENSG00000091129 . [Q92823-4 ]
ENST00000379024 ; ENSP00000368310 ; ENSG00000091129 . [Q92823-6 ]
ENST00000379028 ; ENSP00000368314 ; ENSG00000091129 . [Q92823-1 ]
ENST00000425651 ; ENSP00000401244 ; ENSG00000091129 . [Q92823-1 ]
GeneIDi 4897.
KEGGi hsa:4897.
UCSCi uc003vfc.3. human. [Q92823-4 ]
uc003vfe.3. human. [Q92823-3 ]
uc011kmk.2. human. [Q92823-1 ]

Organism-specific databases

CTDi 4897.
GeneCardsi GC07M107788.
HGNCi HGNC:7994. NRCAM.
HPAi HPA012606.
MIMi 601581. gene.
neXtProti NX_Q92823.
PharmGKBi PA31773.
HUGEi Search...
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG293951.
GeneTreei ENSGT00760000118840.
HOGENOMi HOG000231380.
HOVERGENi HBG000144.
InParanoidi Q92823.
KOi K06756.
OMAi YANISWE.
OrthoDBi EOG7R56RM.
PhylomeDBi Q92823.
TreeFami TF351098.

Enzyme and pathway databases

Reactomei REACT_22266. Interaction between L1 and Ankyrins.
REACT_22312. Neurofascin interactions.
REACT_22329. NrCAM interactions.

Miscellaneous databases

ChiTaRSi NRCAM. human.
EvolutionaryTracei Q92823.
GeneWikii NRCAM.
GenomeRNAii 4897.
NextBioi 18839.
PROi Q92823.
SOURCEi Search...

Gene expression databases

Bgeei Q92823.
CleanExi HS_NRCAM.
ExpressionAtlasi Q92823. baseline and differential.
Genevestigatori Q92823.

Family and domain databases

Gene3Di 2.60.40.10. 11 hits.
InterProi IPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view ]
Pfami PF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 4 hits.
[Graphical view ]
SMARTi SM00060. FN3. 5 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view ]
SUPFAMi SSF49265. SSF49265. 3 hits.
PROSITEi PS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31."
    Lane R.P., Chen X.-N., Yamakawa K., Vielmetter J., Korenberg J.R., Dreyer W.J.
    Genomics 35:456-465(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
    Tissue: Brain.
  2. "The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily."
    Dry K., Kenwrick S., Rosenthal A., Platzer M.
    Gene 273:115-122(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 5).
  3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
    Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
    DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-545.
    Tissue: Brain.
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Amygdala.
  5. "The DNA sequence of human chromosome 7."
    Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L.
    , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
    Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "Human chromosome 7: DNA sequence and biology."
    Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S.
    , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
    Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-545.
  9. "Temporal and spatial regulation of alternative splicing for human NrCAM in neural and non neural tissues."
    Wang B., Williams H., Du J., Terrett J., Kenwricl S.
    Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-1304 (ISOFORM 1).
    Tissue: Brain.
  10. "Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
    Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
    J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
    Tissue: Plasma.
  11. "Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
    Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
    J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
    Tissue: Liver.
  12. Cited for: GLYCOSYLATION AT ASN-858.
  13. "Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
    Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
    J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH MYOC.
  14. "Solution structure of the first fibronectin type III domain of human KIAA0343 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2003) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 638-751.
  15. "Solution structure of the third fibronectin III domain of human KIAA0343 protein."
    RIKEN structural genomics initiative (RSGI)
    Submitted (NOV-2003) to the PDB data bank
    Cited for: STRUCTURE BY NMR OF 838-950.
  16. Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-1093 AND VAL-1116.

Entry informationi

Entry nameiNRCAM_HUMAN
AccessioniPrimary (citable) accession number: Q92823
Secondary accession number(s): A4D0S3
, E9PDA4, O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 25, 2008
Last modified: October 29, 2014
This is version 143 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

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