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Q92823 (NRCAM_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 140. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (6) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Web links·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neuronal cell adhesion molecule

Short name=Nr-CAM
Alternative name(s):
Neuronal surface protein Bravo
Short name=hBravo
NgCAM-related cell adhesion molecule
Short name=Ng-CAM-related
Gene names
Name:NRCAM
Synonyms:KIAA0343
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length1304 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Cell adhesion, ankyrin-binding protein involved in neuron-neuron adhesion. May play a role in the molecular assembly of the nodes of Ranvier By similarity.

Subunit structure

Probable constituent of a neurofascin/NRCAM/ankyrin-G complex. Interacts with GLDN/gliomedin By similarity. Interacts with MYOC. Ref.13

Subcellular location

Cell membrane; Single-pass type I membrane protein Potential.

Tissue specificity

Detected in all the examined tissues. In the brain it was detected in the amygdala, caudate nucleus, corpus callosum, hippocampus, hypothalamus, substantia nigra, subthalamic nucleus and thalamus.

Sequence similarities

Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.

Contains 5 fibronectin type-III domains.

Contains 6 Ig-like C2-type (immunoglobulin-like) domains.

Sequence caution

The sequence AAC50765.1 differs from that shown. Reason: Erroneous initiation.

The sequence BAA20801.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Biological processCell adhesion
   Cellular componentCell membrane
Membrane
   Coding sequence diversityAlternative splicing
Polymorphism
   DomainImmunoglobulin domain
Repeat
Signal
Transmembrane
Transmembrane helix
   PTMDisulfide bond
Glycoprotein
Phosphoprotein
   Technical term3D-structure
Complete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processangiogenesis

Inferred from expression pattern PubMed 11866539. Source: UniProtKB

axon guidance

Traceable author statement. Source: Reactome

axonal fasciculation

Non-traceable author statement Ref.1. Source: UniProtKB

axonogenesis

Non-traceable author statement Ref.1. Source: UniProtKB

central nervous system development

Non-traceable author statement Ref.1. Source: UniProtKB

clustering of voltage-gated sodium channels

Inferred from direct assay PubMed 14602817. Source: UniProtKB

heterotypic cell-cell adhesion

Inferred from electronic annotation. Source: Ensembl

neuron migration

Non-traceable author statement Ref.2. Source: UniProtKB

neuronal action potential propagation

Inferred from electronic annotation. Source: Ensembl

positive regulation of neuron differentiation

Non-traceable author statement Ref.1. Source: UniProtKB

protein localization

Inferred from electronic annotation. Source: Ensembl

regulation of axon extension

Non-traceable author statement Ref.1. Source: UniProtKB

retinal ganglion cell axon guidance

Inferred from electronic annotation. Source: Ensembl

single organismal cell-cell adhesion

Non-traceable author statement Ref.1. Source: UniProtKB

synapse assembly

Traceable author statement Ref.1. Source: UniProtKB

   Cellular_componentaxon initial segment

Inferred from sequence or structural similarity. Source: BHF-UCL

external side of plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

integral component of plasma membrane

Non-traceable author statement Ref.1. Source: UniProtKB

neuron projection

Non-traceable author statement Ref.1. Source: UniProtKB

plasma membrane

Traceable author statement. Source: Reactome

synapse

Inferred from electronic annotation. Source: Ensembl

   Molecular_functionankyrin binding

Inferred from direct assay PubMed 14602817. Source: UniProtKB

protein binding

Inferred from physical interaction Ref.13. Source: UniProtKB

Complete GO annotation...

Alternative products

This entry describes 6 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q92823-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92823-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1226-1236: SDAEDHKPLKK → RLFSFVSSASF
     1237-1304: Missing.
Isoform 3 (identifier: Q92823-3)

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1051-1155: Missing.
Note: No experimental confirmation available.
Isoform 4 (identifier: Q92823-4)

The sequence of this isoform differs from the canonical sequence as follows:
     35-40: Missing.
     635-644: Missing.
     1051-1155: Missing.
Note: No experimental confirmation available.
Isoform 5 (identifier: Q92823-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1225-1225: Y → YRSLE
Isoform 6 (identifier: Q92823-6)

The sequence of this isoform differs from the canonical sequence as follows:
     241-259: Missing.
     1063-1155: Missing.
Note: No experimental confirmation available.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 2424 Potential
Chain25 – 13041280Neuronal cell adhesion molecule
PRO_0000015057

Regions

Topological domain25 – 11671143Extracellular Potential
Transmembrane1168 – 119023Helical; Potential
Topological domain1191 – 1304114Cytoplasmic Potential
Domain46 – 13489Ig-like 1
Domain141 – 23595Ig-like 2
Domain267 – 35690Ig-like 3
Domain361 – 44888Ig-like 4
Domain454 – 54188Ig-like 5
Domain545 – 63288Ig-like 6
Domain649 – 74496Fibronectin type-III 1
Domain746 – 84398Fibronectin type-III 2
Domain848 – 950103Fibronectin type-III 3
Domain954 – 105198Fibronectin type-III 4
Domain1064 – 115693Fibronectin type-III 5

Amino acid modifications

Modified residue12711Phosphoserine By similarity
Glycosylation831N-linked (GlcNAc...) Potential
Glycosylation2231N-linked (GlcNAc...) Potential
Glycosylation2451N-linked (GlcNAc...) Potential
Glycosylation2511N-linked (GlcNAc...) Potential
Glycosylation2761N-linked (GlcNAc...) Ref.10 Ref.11
Glycosylation3141N-linked (GlcNAc...) Potential
Glycosylation4331N-linked (GlcNAc...) Potential
Glycosylation5071N-linked (GlcNAc...) Potential
Glycosylation6191N-linked (GlcNAc...) Potential
Glycosylation7161N-linked (GlcNAc...) Potential
Glycosylation8021N-linked (GlcNAc...) Potential
Glycosylation8581N-linked (GlcNAc...) (complex) Ref.12
Glycosylation9931N-linked (GlcNAc...) Potential
Glycosylation10091N-linked (GlcNAc...) Potential
Glycosylation10191N-linked (GlcNAc...) Potential
Glycosylation10721N-linked (GlcNAc...) Potential
Glycosylation10831N-linked (GlcNAc...) Potential
Glycosylation11151N-linked (GlcNAc...) Potential
Disulfide bond68 ↔ 123 Potential
Disulfide bond167 ↔ 218 Potential
Disulfide bond292 ↔ 340 Potential
Disulfide bond382 ↔ 432 Potential
Disulfide bond476 ↔ 525 Potential
Disulfide bond567 ↔ 616 Potential

Natural variations

Alternative sequence35 – 406Missing in isoform 4.
VSP_007837
Alternative sequence241 – 25919Missing in isoform 3 and isoform 6.
VSP_007838
Alternative sequence635 – 64410Missing in isoform 4.
VSP_007839
Alternative sequence1051 – 1155105Missing in isoform 3 and isoform 4.
VSP_007840
Alternative sequence1063 – 115593Missing in isoform 6.
VSP_045040
Alternative sequence12251Y → YRSLE in isoform 5.
VSP_007843
Alternative sequence1226 – 123611SDAEDHKPLKK → RLFSFVSSASF in isoform 2.
VSP_007841
Alternative sequence1237 – 130468Missing in isoform 2.
VSP_007842
Natural variant5451P → A. Ref.3 Ref.6 Ref.7 Ref.8
Corresponds to variant rs6958498 [ dbSNP | Ensembl ].
VAR_047550
Natural variant10931H → P in a breast cancer sample; somatic mutation. Ref.16
VAR_035528
Natural variant11161G → V in a breast cancer sample; somatic mutation. Ref.16
VAR_035529

Experimental info

Sequence conflict4871E → Q in CAA04507. Ref.9
Sequence conflict5121I → IKDATWIVKEI in AAC50765. Ref.1
Sequence conflict541 – 55010Missing in AAC50765. Ref.1
Sequence conflict6511F → L in CAA04507. Ref.9
Sequence conflict679 – 6824KFII → TIHD in CAA04507. Ref.9
Sequence conflict7101K → N in BAA20801. Ref.3
Sequence conflict7641V → E in AAC50765. Ref.1
Sequence conflict7751S → F in CAA04507. Ref.9
Sequence conflict7901D → V in CAA04507. Ref.9
Sequence conflict9211F → L in CAD97960. Ref.4
Sequence conflict9541A → V in CAA04507. Ref.9
Sequence conflict9941S → N in CAA04507. Ref.9
Sequence conflict10081A → T in CAD97960. Ref.4
Sequence conflict10211S → T in CAA04507. Ref.9
Sequence conflict10681P → T in AAC50765. Ref.1
Sequence conflict1093 – 10942HV → YA in CAA04507. Ref.9
Sequence conflict11341V → F in CAA04507. Ref.9
Sequence conflict1141 – 11433DSG → GPR in CAA04507. Ref.9
Sequence conflict11491D → G in CAA04507. Ref.9
Sequence conflict12561V → L in CAA04507. Ref.9

Secondary structure

.................................. 1304
Helix Strand Turn

Details...

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 25, 2008. Version 3.
Checksum: 1F2698BC7DB5C363

FASTA1,304143,890
        10         20         30         40         50         60 
MQLKIMPKKK RLSAGRVPLI LFLCQMISAL EVPLDPKLLE DLVQPPTITQ QSPKDYIIDP 

        70         80         90        100        110        120 
RENIVIQCEA KGKPPPSFSW TRNGTHFDID KDPLVTMKPG TGTLIINIMS EGKAETYEGV 

       130        140        150        160        170        180 
YQCTARNERG AAVSNNIVVR PSRSPLWTKE KLEPITLQSG QSLVLPCRPP IGLPPPIIFW 

       190        200        210        220        230        240 
MDNSFQRLPQ SERVSQGLNG DLYFSNVLPE DTREDYICYA RFNHTQTIQQ KQPISVKVIS 

       250        260        270        280        290        300 
VDELNDTIAA NLSDTEFYGA KSSRERPPTF LTPEGNASNK EELRGNVLSL ECIAEGLPTP 

       310        320        330        340        350        360 
IIYWAKEDGM LPKNRTVYKN FEKTLQIIHV SEADSGNYQC IAKNALGAIH HTISVRVKAA 

       370        380        390        400        410        420 
PYWITAPQNL VLSPGEDGTL ICRANGNPKP RISWLTNGVP IEIAPDDPSR KIDGDTIIFS 

       430        440        450        460        470        480 
NVQERSSAVY QCNASNEYGY LLANAFVNVL AEPPRILTPA NTLYQVIANR PALLDCAFFG 

       490        500        510        520        530        540 
SPLPTIEWFK GAKGSALHED IYVLHENGTL EIPVAQKDST GTYTCVARNK LGMAKNEVHL 

       550        560        570        580        590        600 
EIKDPTWIVK QPEYAVVQRG SMVSFECKVK HDHTLSLTVL WLKDNRELPS DERFTVDKDH 

       610        620        630        640        650        660 
LVVADVSDDD SGTYTCVANT TLDSVSASAV LSVVAPTPTP APVYDVPNPP FDLELTDQLD 

       670        680        690        700        710        720 
KSVQLSWTPG DDNNSPITKF IIEYEDAMHK PGLWHHQTEV SGTQTTAQLK LSPYVNYSFR 

       730        740        750        760        770        780 
VMAVNSIGKS LPSEASEQYL TKASEPDKNP TAVEGLGSEP DNLVITWKPL NGFESNGPGL 

       790        800        810        820        830        840 
QYKVSWRQKD GDDEWTSVVV ANVSKYIVSG TPTFVPYLIK VQALNDMGFA PEPAVVMGHS 

       850        860        870        880        890        900 
GEDLPMVAPG NVRVNVVNST LAEVHWDPVP LKSIRGHLQG YRIYYWKTQS SSKRNRRHIE 

       910        920        930        940        950        960 
KKILTFQGSK THGMLPGLEP FSHYTLNVRV VNGKGEGPAS PDRVFNTPEG VPSAPSSLKI 

       970        980        990       1000       1010       1020 
VNPTLDSLTL EWDPPSHPNG ILTEYTLKYQ PINSTHELGP LVDLKIPANK TRWTLKNLNF 

      1030       1040       1050       1060       1070       1080 
STRYKFYFYA QTSAGSGSQI TEEAVTTVDE AGILPPDVGA GKVQAVNPRI SNLTAAAAET 

      1090       1100       1110       1120       1130       1140 
YANISWEYEG PEHVNFYVEY GVAGSKEEWR KEIVNGSRSF FGLKGLMPGT AYKVRVGAVG 

      1150       1160       1170       1180       1190       1200 
DSGFVSSEDV FETGPAMASR QVDIATQGWF IGLMCAVALL ILILLIVCFI RRNKGGKYPV 

      1210       1220       1230       1240       1250       1260 
KEKEDAHADP EIQPMKEDDG TFGEYSDAED HKPLKKGSRT PSDRTVKKED SDDSLVDYGE 

      1270       1280       1290       1300 
GVNGQFNEDG SFIGQYSGKK EKEPAEGNES SEAPSPVNAM NSFV 

« Hide

Isoform 2 [UniParc].

Checksum: 0C21479D02E6CCE2
Show »

FASTA1,236136,614
Isoform 3 [UniParc].

Checksum: DF33D4380A609B75
Show »

FASTA1,180130,668
Isoform 4 [UniParc].

Checksum: FEF6A39C50DE9664
Show »

FASTA1,183131,046
Isoform 5 [UniParc].

Checksum: 7019F3533A0F445E
Show »

FASTA1,308144,375
Isoform 6 [UniParc].

Checksum: 0D9E6E1CDB666115
Show »

FASTA1,192131,744

References

« Hide 'large scale' references
[1]"Characterization of a highly conserved human homolog to the chicken neural cell surface protein Bravo/Nr-CAM that maps to chromosome band 7q31."
Lane R.P., Chen X.-N., Yamakawa K., Vielmetter J., Korenberg J.R., Dreyer W.J.
Genomics 35:456-465(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORM 1).
Tissue: Brain.
[2]"The complete sequence of the human locus for NgCAM-related cell adhesion molecule reveals a novel alternative exon in chick and man and conserved genomic organization for the L1 subfamily."
Dry K., Kenwrick S., Rosenthal A., Platzer M.
Gene 273:115-122(2001) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS 2 AND 5).
[3]"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), VARIANT ALA-545.
Tissue: Brain.
[4]"The full-ORF clone resource of the German cDNA consortium."
Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I.
BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
Tissue: Amygdala.
[5]"The DNA sequence of human chromosome 7."
Hillier L.W., Fulton R.S., Fulton L.A., Graves T.A., Pepin K.H., Wagner-McPherson C., Layman D., Maas J., Jaeger S., Walker R., Wylie K., Sekhon M., Becker M.C., O'Laughlin M.D., Schaller M.E., Fewell G.A., Delehaunty K.D., Miner T.L. expand/collapse author list , Nash W.E., Cordes M., Du H., Sun H., Edwards J., Bradshaw-Cordum H., Ali J., Andrews S., Isak A., Vanbrunt A., Nguyen C., Du F., Lamar B., Courtney L., Kalicki J., Ozersky P., Bielicki L., Scott K., Holmes A., Harkins R., Harris A., Strong C.M., Hou S., Tomlinson C., Dauphin-Kohlberg S., Kozlowicz-Reilly A., Leonard S., Rohlfing T., Rock S.M., Tin-Wollam A.-M., Abbott A., Minx P., Maupin R., Strowmatt C., Latreille P., Miller N., Johnson D., Murray J., Woessner J.P., Wendl M.C., Yang S.-P., Schultz B.R., Wallis J.W., Spieth J., Bieri T.A., Nelson J.O., Berkowicz N., Wohldmann P.E., Cook L.L., Hickenbotham M.T., Eldred J., Williams D., Bedell J.A., Mardis E.R., Clifton S.W., Chissoe S.L., Marra M.A., Raymond C., Haugen E., Gillett W., Zhou Y., James R., Phelps K., Iadanoto S., Bubb K., Simms E., Levy R., Clendenning J., Kaul R., Kent W.J., Furey T.S., Baertsch R.A., Brent M.R., Keibler E., Flicek P., Bork P., Suyama M., Bailey J.A., Portnoy M.E., Torrents D., Chinwalla A.T., Gish W.R., Eddy S.R., McPherson J.D., Olson M.V., Eichler E.E., Green E.D., Waterston R.H., Wilson R.K.
Nature 424:157-164(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[6]"Human chromosome 7: DNA sequence and biology."
Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. expand/collapse author list , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C.
Science 300:767-772(2003) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
[7]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA], VARIANT ALA-545.
[8]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 6), VARIANT ALA-545.
[9]"Temporal and spatial regulation of alternative splicing for human NrCAM in neural and non neural tissues."
Wang B., Williams H., Du J., Terrett J., Kenwricl S.
Submitted (AUG-1997) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 6-1304 (ISOFORM 1).
Tissue: Brain.
[10]"Human plasma N-glycoproteome analysis by immunoaffinity subtraction, hydrazide chemistry, and mass spectrometry."
Liu T., Qian W.-J., Gritsenko M.A., Camp D.G. II, Monroe M.E., Moore R.J., Smith R.D.
J. Proteome Res. 4:2070-2080(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
Tissue: Plasma.
[11]"Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry."
Chen R., Jiang X., Sun D., Han G., Wang F., Ye M., Wang L., Zou H.
J. Proteome Res. 8:651-661(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION [LARGE SCALE ANALYSIS] AT ASN-276.
Tissue: Liver.
[12]"A strategy for precise and large scale identification of core fucosylated glycoproteins."
Jia W., Lu Z., Fu Y., Wang H.P., Wang L.H., Chi H., Yuan Z.F., Zheng Z.B., Song L.N., Han H.H., Liang Y.M., Wang J.L., Cai Y., Zhang Y.K., Deng Y.L., Ying W.T., He S.M., Qian X.H.
Mol. Cell. Proteomics 8:913-923(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: GLYCOSYLATION AT ASN-858.
[13]"Myocilin mediates myelination in the peripheral nervous system through ErbB2/3 signaling."
Kwon H.S., Johnson T.V., Joe M.K., Abu-Asab M., Zhang J., Chan C.C., Tomarev S.I.
J. Biol. Chem. 288:26357-26371(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: INTERACTION WITH MYOC.
[14]"Solution structure of the first fibronectin type III domain of human KIAA0343 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2003) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 638-751.
[15]"Solution structure of the third fibronectin III domain of human KIAA0343 protein."
RIKEN structural genomics initiative (RSGI)
Submitted (NOV-2003) to the PDB data bank
Cited for: STRUCTURE BY NMR OF 838-950.
[16]"The consensus coding sequences of human breast and colorectal cancers."
Sjoeblom T., Jones S., Wood L.D., Parsons D.W., Lin J., Barber T.D., Mandelker D., Leary R.J., Ptak J., Silliman N., Szabo S., Buckhaults P., Farrell C., Meeh P., Markowitz S.D., Willis J., Dawson D., Willson J.K.V. expand/collapse author list , Gazdar A.F., Hartigan J., Wu L., Liu C., Parmigiani G., Park B.H., Bachman K.E., Papadopoulos N., Vogelstein B., Kinzler K.W., Velculescu V.E.
Science 314:268-274(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: VARIANTS [LARGE SCALE ANALYSIS] PRO-1093 AND VAL-1116.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U55258 Genomic DNA. Translation: AAC50765.1. Different initiation.
AF172277 Genomic DNA. Translation: AAF22282.1.
AF172277 Genomic DNA. Translation: AAF22283.1.
AB002341 mRNA. Translation: BAA20801.2. Different initiation.
BX538010 mRNA. Translation: CAD97960.1.
AC005683 Genomic DNA. No translation available.
AC007567 Genomic DNA. No translation available.
CH236947 Genomic DNA. Translation: EAL24386.1.
CH471070 Genomic DNA. Translation: EAW83429.1.
BC115736 mRNA. Translation: AAI15737.1.
AJ001054 mRNA. Translation: CAA04504.1.
AJ001057 mRNA. Translation: CAA04507.1.
CCDSCCDS47686.1. [Q92823-1]
CCDS55153.1. [Q92823-6]
CCDS5751.1. [Q92823-4]
RefSeqNP_001032209.1. NM_001037132.2. [Q92823-1]
NP_001180511.1. NM_001193582.1.
NP_001180512.1. NM_001193583.1. [Q92823-6]
NP_001180513.1. NM_001193584.1. [Q92823-3]
NP_005001.3. NM_005010.4. [Q92823-4]
XP_005250430.1. XM_005250373.2. [Q92823-1]
XP_006716066.1. XM_006716003.1. [Q92823-5]
XP_006716067.1. XM_006716004.1. [Q92823-5]
UniGeneHs.21422.

3D structure databases

PDBe
RCSB-PDB
PDBj
EntryMethodResolution (Å)ChainPositionsPDBsum
1UENNMR-A839-950[»]
1UEYNMR-A638-751[»]
ProteinModelPortalQ92823.
SMRQ92823. Positions 42-835, 842-1143.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110953. 7 interactions.
IntActQ92823. 5 interactions.
STRING9606.ENSP00000368314.

PTM databases

PhosphoSiteQ92823.

Polymorphism databases

DMDM215274127.

Proteomic databases

MaxQBQ92823.
PaxDbQ92823.
PRIDEQ92823.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000351718; ENSP00000325269; ENSG00000091129. [Q92823-4]
ENST00000379024; ENSP00000368310; ENSG00000091129. [Q92823-6]
ENST00000379028; ENSP00000368314; ENSG00000091129. [Q92823-1]
ENST00000425651; ENSP00000401244; ENSG00000091129. [Q92823-1]
GeneID4897.
KEGGhsa:4897.
UCSCuc003vfc.3. human. [Q92823-4]
uc003vfe.3. human. [Q92823-3]
uc011kmk.2. human. [Q92823-1]

Organism-specific databases

CTD4897.
GeneCardsGC07M107788.
HGNCHGNC:7994. NRCAM.
HPAHPA012606.
MIM601581. gene.
neXtProtNX_Q92823.
PharmGKBPA31773.
HUGESearch...
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG293951.
HOGENOMHOG000231380.
HOVERGENHBG000144.
KOK06756.
OMAYANISWE.
OrthoDBEOG7R56RM.
PhylomeDBQ92823.
TreeFamTF351098.

Enzyme and pathway databases

ReactomeREACT_111045. Developmental Biology.

Gene expression databases

ArrayExpressQ92823.
BgeeQ92823.
CleanExHS_NRCAM.
GenevestigatorQ92823.

Family and domain databases

Gene3D2.60.40.10. 11 hits.
InterProIPR003961. Fibronectin_type3.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003006. Ig/MHC_CS.
IPR013098. Ig_I-set.
IPR003599. Ig_sub.
IPR003598. Ig_sub2.
IPR026966. Neurofascin/L1/NrCAM_C.
[Graphical view]
PfamPF13882. Bravo_FIGEY. 1 hit.
PF00041. fn3. 5 hits.
PF07679. I-set. 4 hits.
[Graphical view]
SMARTSM00060. FN3. 5 hits.
SM00409. IG. 3 hits.
SM00408. IGc2. 3 hits.
[Graphical view]
SUPFAMSSF49265. SSF49265. 3 hits.
PROSITEPS50853. FN3. 5 hits.
PS50835. IG_LIKE. 6 hits.
PS00290. IG_MHC. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSNRCAM. human.
EvolutionaryTraceQ92823.
GeneWikiNRCAM.
GenomeRNAi4897.
NextBio18839.
PROQ92823.
SOURCESearch...

Entry information

Entry nameNRCAM_HUMAN
AccessionPrimary (citable) accession number: Q92823
Secondary accession number(s): A4D0S3 expand/collapse secondary AC list , E9PDA4, O15051, O15179, Q14BM2, Q9UHI3, Q9UHI4
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2003
Last sequence update: November 25, 2008
Last modified: July 9, 2014
This is version 140 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

PDB cross-references

Index of Protein Data Bank (PDB) cross-references

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 7

Human chromosome 7: entries, gene names and cross-references to MIM