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Reviewed, UniProtKB/Swiss-Prot Q92819 (HAS2_HUMAN)

Last modified June 16, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (4) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents

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Names and origin

Protein namesRecommended name:
    Hyaluronan synthase 2
    EC=2.4.1.212
Alternative name(s):
    Hyaluronate synthase 2
    Hyaluronic acid synthase 2
      Short name=HA synthase 2
Gene names
Name: HAS2
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

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Protein attributes

Sequence length552 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

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General annotation (Comments)

Function

Plays a role in hyaluronan/hyaluronic acid (HA) synthesis.

Catalytic activity

UDP-alpha-N-acetyl-D-glucosamine + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan) = UDP + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-(nascent hyaluronan).

UDP-alpha-D-glucuronate + N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan) = UDP + beta-D-glucuronosyl-(1->3)-N-acetyl-beta-D-glucosaminyl-(1->4)-beta-D-glucuronosyl-(1->3)-(nascent hyaluronan).

Cofactor

Magnesium.

Pathway

Glycan biosynthesis; hyaluronan biosynthesis.

Subcellular location

Membrane; Multi-pass membrane protein Probable.

Tissue specificity

Expressed in fibroblasts.

Involvement in disease

A chromosomal rearrangement involving HAS2 may be a cause of lipoblastomas, which are benign tumors resulting from transformation of adipocytes, usually diagnosed in children. 8q12.1 to 8q24.1 intrachromosomal rearrangement with PLAG1.

Sequence similarities

Belongs to the nodC/HAS family.

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Ontologies

Keywords
   Cellular componentMembrane
   Coding sequence diversityChromosomal rearrangement
   DomainTransmembrane
   Molecular functionGlycosyltransferase
Transferase
Gene Ontology (GO)
   Cellular componentintegral to plasma membrane

Traceable author statement. Source: ProtInc

   Molecular functionhyaluronan synthase activity

Inferred from electronic annotation. Source: EC

Complete GO annotation...

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Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 552552Hyaluronan synthase 2
PRO_0000197173

Regions

Topological domain1 – 1111Cytoplasmic Potential
Transmembrane12 – 32211 Potential
Topological domain33 – 4513Extracellular Potential
Transmembrane46 – 66212 Potential
Topological domain67 – 374308Cytoplasmic Potential
Transmembrane375 – 395213 Potential
Topological domain396 – 4027Extracellular Potential
Transmembrane403 – 423214 Potential
Topological domain424 – 4296Cytoplasmic Potential
Transmembrane430 – 450215 Potential
Topological domain451 – 47525Extracellular Potential
Transmembrane476 – 496216 Potential
Topological domain497 – 51014Cytoplasmic Potential
Transmembrane511 – 531217 Potential
Topological domain532 – 55221Extracellular Potential

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Sequences

Sequence LengthMass (Da)Tools
Q92819-1 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: EEEF58D97B131F9D

FASTA55263,566
        10         20         30         40         50         60 
MHCERFLCIL RIIGTTLFGV SLLLGITAAY IVGYQFIQTD NYYFSFGLYG AFLASHLIIQ 

        70         80         90        100        110        120 
SLFAFLEHRK MKKSLETPIK LNKTVALCIA AYQEDPDYLR KCLQSVKRLT YPGIKVVMVI 

       130        140        150        160        170        180 
DGNSEDDLYM MDIFSEVMGR DKSATYIWKN NFHEKGPGET DESHKESSQH VTQLVLSNKS 

       190        200        210        220        230        240 
ICIMQKWGGK REVMYTAFRA LGRSVDYVQV CDSDTMLDPA SSVEMVKVLE EDPMVGGVGG 

       250        260        270        280        290        300 
DVQILNKYDS WISFLSSVRY WMAFNIERAC QSYFGCVQCI SGPLGMYRNS LLHEFVEDWY 

       310        320        330        340        350        360 
NQEFMGNQCS FGDDRHLTNR VLSLGYATKY TARSKCLTET PIEYLRWLNQ QTRWSKSYFR 

       370        380        390        400        410        420 
EWLYNAMWFH KHHLWMTYEA IITGFFPFFL IATVIQLFYR GKIWNILLFL LTVQLVGLIK 

       430        440        450        460        470        480 
SSFASCLRGN IVMVFMSLYS VLYMSSLLPA KMFAIATINK AGWGTSGRKT IVVNFIGLIP 

       490        500        510        520        530        540 
VSVWFTILLG GVIFTIYKES KRPFSESKQT VLIVGTLLYA CYWVMLLTLY VVLINKCGRR 

       550 
KKGQQYDMVL DV

« Hide

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References

« Hide 'large scale' references
[1]"Molecular identification of a putative human hyaluronan synthase."
Watanabe K., Yamaguchi Y.
J. Biol. Chem. 271:22945-22948(1996) [PubMed: 8798477] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[3]"PLAG1-HAS2 fusion in lipoblastoma with masked 8q intrachromosomal rearrangement."
Morerio C., Rapella A., Rosanda C., Tassano E., Gambini C., Romagnoli G., Panarello C.
Cancer Genet. Cytogenet. 156:183-184(2005) [PubMed: 15642402] [Abstract]
Cited for: CHROMOSOMAL REARRANGEMENT WITH PLAG1.
+Additional computationally mapped references.

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Web resources

GGDB

GlycoGene database"

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Cross-references

Sequence databases

U54804 mRNA. Translation: AAC50692.1.
BC069353 mRNA. Translation: AAH69353.1.
BC109071 mRNA. Translation: AAI09072.1.
BC109072 mRNA. Translation: AAI09073.1.
IPIIPI00023713.
RefSeqNP_005319.1.
UniGeneHs.159226

3D structure databases

ModBaseSearch...

Protein family/group databases

CAZyGT2. Glycosyltransferase Family 2.

Proteomic databases

PRIDEQ92819.

Genome annotation databases

EnsemblENSG00000170961. Homo sapiens. [Contig view]
GeneID3037.
KEGGhsa:3037.

Organism-specific databases

GeneCardsGC08M122694.
H-InvDBHIX0034350.
HGNCHGNC:4819. HAS2.
MIM601636. gene.
PharmGKBPA29195.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ92819.
HOVERGENQ92819.
OMAQ92819. CERFICI.

Enzyme and pathway databases

BRENDA2.4.1.212. 247.

Gene expression databases

ArrayExpressQ92819.
BgeeQ92819.
CleanExHS_HAS2.
GermOnlineENSG00000170961. Homo sapiens.

Family and domain databases

InterProIPR001173. Glyco_trans_2.
[Graphical view]
PfamPF00535. Glycos_transf_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio12022.
SOURCESearch...

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Entry information

Entry nameHAS2_HUMAN
AccessionPrimary (citable) accession number: Q92819
Secondary accession number(s): Q32MM3
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 1, 1997
Last modified: June 16, 2009
This is version 69 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

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Relevant documents

Human chromosome 8

Human chromosome 8: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

PATHWAY comments

Index of metabolic and biosynthesis pathways

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Web resources · Cross-references · Entry information · Relevant documents