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Q92806

- KCNJ9_HUMAN

UniProt

Q92806 - KCNJ9_HUMAN

Protein

G protein-activated inward rectifier potassium channel 3

Gene

KCNJ9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 132 (01 Oct 2014)
      Sequence version 2 (06 Feb 2007)
      Previous versions | rss
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    Functioni

    This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei150 – 1501Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

    GO - Molecular functioni

    1. G-protein activated inward rectifier potassium channel activity Source: InterPro
    2. protein binding Source: BHF-UCL

    GO - Biological processi

    1. synaptic transmission Source: Reactome

    Keywords - Molecular functioni

    Ion channel, Voltage-gated channel

    Keywords - Biological processi

    Ion transport, Potassium transport, Transport

    Keywords - Ligandi

    Potassium

    Enzyme and pathway databases

    ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    G protein-activated inward rectifier potassium channel 3
    Short name:
    GIRK-3
    Alternative name(s):
    Inward rectifier K(+) channel Kir3.3
    Potassium channel, inwardly rectifying subfamily J member 9
    Gene namesi
    Name:KCNJ9
    Synonyms:GIRK3
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:6270. KCNJ9.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW
    2. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Membrane

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30051.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 393393G protein-activated inward rectifier potassium channel 3PRO_0000154950Add
    BLAST

    Proteomic databases

    PaxDbiQ92806.
    PRIDEiQ92806.

    PTM databases

    PhosphoSiteiQ92806.

    Expressioni

    Gene expression databases

    BgeeiQ92806.
    CleanExiHS_KCNJ9.
    GenevestigatoriQ92806.

    Interactioni

    Subunit structurei

    Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane By similarity.By similarity

    Protein-protein interaction databases

    BioGridi109967. 2 interactions.
    STRINGi9606.ENSP00000357067.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92806.
    SMRiQ92806. Positions 22-348.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 5757CytoplasmicBy similarityAdd
    BLAST
    Topological domaini83 – 10624ExtracellularBy similarityAdd
    BLAST
    Topological domaini126 – 1349ExtracellularBy similarity
    Topological domaini157 – 393237CytoplasmicBy similarityAdd
    BLAST

    Intramembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Intramembranei107 – 11812Helical; Pore-forming; Name=H5By similarityAdd
    BLAST
    Intramembranei119 – 1257Pore-formingBy similarity

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei58 – 8225Helical; Name=M1By similarityAdd
    BLAST
    Transmembranei135 – 15622Helical; Name=M2By similarityAdd
    BLAST

    Family & Domainsi

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi120 – 1256Selectivity filterBy similarity
    Motifi390 – 3934PDZ-binding

    Domaini

    The PDZ-binding motif specifically binds the PDZ domain of SNX27: the specificity for SNX27 is provided by the 2 residues located upstream (Glu-388 and Ser-389) of the PDZ-binding motif.By similarity

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG72812.
    HOGENOMiHOG000237325.
    HOVERGENiHBG006178.
    InParanoidiQ92806.
    KOiK05002.
    OMAiDYASFHQ.
    OrthoDBiEOG7XPZ5K.
    PhylomeDBiQ92806.
    TreeFamiTF313676.

    Family and domain databases

    Gene3Di2.60.40.1400. 1 hit.
    InterProiIPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003276. K_chnl_inward-rec_Kir3.3.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view]
    PANTHERiPTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF17. PTHR11767:SF17. 1 hit.
    PfamiPF01007. IRK. 1 hit.
    [Graphical view]
    PIRSFiPIRSF005465. GIRK_kir. 1 hit.
    PRINTSiPR01329. KIR33CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMiSSF81296. SSF81296. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92806-1 [UniParc]FASTAAdd to Basket

    « Hide

    MAQENAAFSP GQEEPPRRRG RQRYVEKDGR CNVQQGNVRE TYRYLTDLFT    50
    TLVDLQWRLS LLFFVLAYAL TWLFFGAIWW LIAYGRGDLE HLEDTAWTPC 100
    VNNLNGFVAA FLFSIETETT IGYGHRVITD QCPEGIVLLL LQAILGSMVN 150
    AFMVGCMFVK ISQPNKRAAT LVFSSHAVVS LRDGRLCLMF RVGDLRSSHI 200
    VEASIRAKLI RSRQTLEGEF IPLHQTDLSV GFDTGDDRLF LVSPLVISHE 250
    IDAASPFWEA SRRALERDDF EIVVILEGMV EATGMTCQAR SSYLVDEVLW 300
    GHRFTSVLTL EDGFYEVDYA SFHETFEVPT PSCSARELAE AAARLDAHLY 350
    WSIPSRLDEK VEEEGAGEGA GGEAGADKEQ NGCLPPPESE SKV 393
    Length:393
    Mass (Da):44,020
    Last modified:February 6, 2007 - v2
    Checksum:iC6F79F80A37B01C9
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti366 – 3661A → V.2 Publications
    Corresponds to variant rs3001040 [ dbSNP | Ensembl ].
    VAR_023568

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52152 mRNA. Translation: AAB07043.1.
    AF193615 Genomic DNA. Translation: AAF89098.1.
    AL121987 Genomic DNA. Translation: CAI15268.1.
    CCDSiCCDS1194.1.
    RefSeqiNP_004974.2. NM_004983.2.
    XP_006711369.1. XM_006711306.1.
    UniGeneiHs.66726.

    Genome annotation databases

    EnsembliENST00000368088; ENSP00000357067; ENSG00000162728.
    GeneIDi3765.
    KEGGihsa:3765.
    UCSCiuc001fuy.1. human.

    Polymorphism databases

    DMDMi125987834.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U52152 mRNA. Translation: AAB07043.1 .
    AF193615 Genomic DNA. Translation: AAF89098.1 .
    AL121987 Genomic DNA. Translation: CAI15268.1 .
    CCDSi CCDS1194.1.
    RefSeqi NP_004974.2. NM_004983.2.
    XP_006711369.1. XM_006711306.1.
    UniGenei Hs.66726.

    3D structure databases

    ProteinModelPortali Q92806.
    SMRi Q92806. Positions 22-348.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109967. 2 interactions.
    STRINGi 9606.ENSP00000357067.

    Chemistry

    ChEMBLi CHEMBL3038490.
    GuidetoPHARMACOLOGYi 436.

    PTM databases

    PhosphoSitei Q92806.

    Polymorphism databases

    DMDMi 125987834.

    Proteomic databases

    PaxDbi Q92806.
    PRIDEi Q92806.

    Protocols and materials databases

    DNASUi 3765.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000368088 ; ENSP00000357067 ; ENSG00000162728 .
    GeneIDi 3765.
    KEGGi hsa:3765.
    UCSCi uc001fuy.1. human.

    Organism-specific databases

    CTDi 3765.
    GeneCardsi GC01P160051.
    H-InvDB HIX0028866.
    HGNCi HGNC:6270. KCNJ9.
    MIMi 600932. gene.
    neXtProti NX_Q92806.
    PharmGKBi PA30051.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG72812.
    HOGENOMi HOG000237325.
    HOVERGENi HBG006178.
    InParanoidi Q92806.
    KOi K05002.
    OMAi DYASFHQ.
    OrthoDBi EOG7XPZ5K.
    PhylomeDBi Q92806.
    TreeFami TF313676.

    Enzyme and pathway databases

    Reactomei REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
    REACT_75831. Activation of G protein gated Potassium channels.

    Miscellaneous databases

    GeneWikii KCNJ9.
    GenomeRNAii 3765.
    NextBioi 14763.
    PROi Q92806.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92806.
    CleanExi HS_KCNJ9.
    Genevestigatori Q92806.

    Family and domain databases

    Gene3Di 2.60.40.1400. 1 hit.
    InterProi IPR014756. Ig_E-set.
    IPR016449. K_chnl_inward-rec_Kir.
    IPR003276. K_chnl_inward-rec_Kir3.3.
    IPR013518. K_chnl_inward-rec_Kir_cyto.
    [Graphical view ]
    PANTHERi PTHR11767. PTHR11767. 1 hit.
    PTHR11767:SF17. PTHR11767:SF17. 1 hit.
    Pfami PF01007. IRK. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF005465. GIRK_kir. 1 hit.
    PRINTSi PR01329. KIR33CHANNEL.
    PR01320. KIRCHANNEL.
    SUPFAMi SSF81296. SSF81296. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Co-expression of human Kir3 subunits can yield channels with different functional properties."
      Schoots O., Wilson J.M., Ethier N., Bigras E., Hebert T.E., Van Tol H.H.M.
      Cell. Signal. 11:871-883(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-366.
    2. "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)."
      Vaughn J., Wolford J.K., Prochazka M., Permana P.A.
      Biochem. Biophys. Res. Commun. 274:302-309(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-366.
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKCNJ9_HUMAN
    AccessioniPrimary (citable) accession number: Q92806
    Secondary accession number(s): Q5JW75
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 6, 2007
    Last modified: October 1, 2014
    This is version 132 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3