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Q92806

- KCNJ9_HUMAN

UniProt

Q92806 - KCNJ9_HUMAN

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Protein

G protein-activated inward rectifier potassium channel 3

Gene

KCNJ9

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

This receptor is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei150 – 1501Role in the control of polyamine-mediated channel gating and in the blocking by intracellular magnesiumBy similarity

GO - Molecular functioni

  1. G-protein activated inward rectifier potassium channel activity Source: InterPro

GO - Biological processi

  1. synaptic transmission Source: Reactome
Complete GO annotation...

Keywords - Molecular functioni

Ion channel, Voltage-gated channel

Keywords - Biological processi

Ion transport, Potassium transport, Transport

Keywords - Ligandi

Potassium

Enzyme and pathway databases

ReactomeiREACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Names & Taxonomyi

Protein namesi
Recommended name:
G protein-activated inward rectifier potassium channel 3
Short name:
GIRK-3
Alternative name(s):
Inward rectifier K(+) channel Kir3.3
Potassium channel, inwardly rectifying subfamily J member 9
Gene namesi
Name:KCNJ9
Synonyms:GIRK3
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:6270. KCNJ9.

Subcellular locationi

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
  2. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Membrane

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30051.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 393393G protein-activated inward rectifier potassium channel 3PRO_0000154950Add
BLAST

Proteomic databases

PaxDbiQ92806.
PRIDEiQ92806.

PTM databases

PhosphoSiteiQ92806.

Expressioni

Gene expression databases

BgeeiQ92806.
CleanExiHS_KCNJ9.
GenevestigatoriQ92806.

Interactioni

Subunit structurei

Associates with GIRK1 to form a G-protein-activated heteromultimer pore-forming unit. Interacts (via PDZ-binding motif) with SNX27 (via PDZ domain); the interaction is required when endocytosed to prevent degradation in lysosomes and promote recycling to the plasma membrane (By similarity).By similarity

Protein-protein interaction databases

BioGridi109967. 2 interactions.
STRINGi9606.ENSP00000357067.

Structurei

3D structure databases

ProteinModelPortaliQ92806.
SMRiQ92806. Positions 22-348.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 5757CytoplasmicBy similarityAdd
BLAST
Topological domaini83 – 10624ExtracellularBy similarityAdd
BLAST
Topological domaini126 – 1349ExtracellularBy similarity
Topological domaini157 – 393237CytoplasmicBy similarityAdd
BLAST

Intramembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Intramembranei107 – 11812Helical; Pore-forming; Name=H5By similarityAdd
BLAST
Intramembranei119 – 1257Pore-formingBy similarity

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei58 – 8225Helical; Name=M1By similarityAdd
BLAST
Transmembranei135 – 15622Helical; Name=M2By similarityAdd
BLAST

Family & Domainsi

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi120 – 1256Selectivity filterBy similarity
Motifi390 – 3934PDZ-binding

Domaini

The PDZ-binding motif specifically binds the PDZ domain of SNX27: the specificity for SNX27 is provided by the 2 residues located upstream (Glu-388 and Ser-389) of the PDZ-binding motif.By similarity

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG72812.
GeneTreeiENSGT00760000118842.
HOGENOMiHOG000237325.
HOVERGENiHBG006178.
InParanoidiQ92806.
KOiK05002.
OMAiDYASFHQ.
OrthoDBiEOG7XPZ5K.
PhylomeDBiQ92806.
TreeFamiTF313676.

Family and domain databases

Gene3Di2.60.40.1400. 1 hit.
InterProiIPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003276. K_chnl_inward-rec_Kir3.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view]
PANTHERiPTHR11767. PTHR11767. 1 hit.
PTHR11767:SF17. PTHR11767:SF17. 1 hit.
PfamiPF01007. IRK. 1 hit.
[Graphical view]
PIRSFiPIRSF005465. GIRK_kir. 1 hit.
PRINTSiPR01329. KIR33CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMiSSF81296. SSF81296. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92806-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAQENAAFSP GQEEPPRRRG RQRYVEKDGR CNVQQGNVRE TYRYLTDLFT
60 70 80 90 100
TLVDLQWRLS LLFFVLAYAL TWLFFGAIWW LIAYGRGDLE HLEDTAWTPC
110 120 130 140 150
VNNLNGFVAA FLFSIETETT IGYGHRVITD QCPEGIVLLL LQAILGSMVN
160 170 180 190 200
AFMVGCMFVK ISQPNKRAAT LVFSSHAVVS LRDGRLCLMF RVGDLRSSHI
210 220 230 240 250
VEASIRAKLI RSRQTLEGEF IPLHQTDLSV GFDTGDDRLF LVSPLVISHE
260 270 280 290 300
IDAASPFWEA SRRALERDDF EIVVILEGMV EATGMTCQAR SSYLVDEVLW
310 320 330 340 350
GHRFTSVLTL EDGFYEVDYA SFHETFEVPT PSCSARELAE AAARLDAHLY
360 370 380 390
WSIPSRLDEK VEEEGAGEGA GGEAGADKEQ NGCLPPPESE SKV
Length:393
Mass (Da):44,020
Last modified:February 6, 2007 - v2
Checksum:iC6F79F80A37B01C9
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti366 – 3661A → V.2 Publications
Corresponds to variant rs3001040 [ dbSNP | Ensembl ].
VAR_023568

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52152 mRNA. Translation: AAB07043.1.
AF193615 Genomic DNA. Translation: AAF89098.1.
AL121987 Genomic DNA. Translation: CAI15268.1.
CCDSiCCDS1194.1.
RefSeqiNP_004974.2. NM_004983.2.
XP_006711369.1. XM_006711306.1.
UniGeneiHs.66726.

Genome annotation databases

EnsembliENST00000368088; ENSP00000357067; ENSG00000162728.
GeneIDi3765.
KEGGihsa:3765.
UCSCiuc001fuy.1. human.

Polymorphism databases

DMDMi125987834.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
U52152 mRNA. Translation: AAB07043.1 .
AF193615 Genomic DNA. Translation: AAF89098.1 .
AL121987 Genomic DNA. Translation: CAI15268.1 .
CCDSi CCDS1194.1.
RefSeqi NP_004974.2. NM_004983.2.
XP_006711369.1. XM_006711306.1.
UniGenei Hs.66726.

3D structure databases

ProteinModelPortali Q92806.
SMRi Q92806. Positions 22-348.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 109967. 2 interactions.
STRINGi 9606.ENSP00000357067.

Chemistry

ChEMBLi CHEMBL3038490.
GuidetoPHARMACOLOGYi 436.

PTM databases

PhosphoSitei Q92806.

Polymorphism databases

DMDMi 125987834.

Proteomic databases

PaxDbi Q92806.
PRIDEi Q92806.

Protocols and materials databases

DNASUi 3765.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000368088 ; ENSP00000357067 ; ENSG00000162728 .
GeneIDi 3765.
KEGGi hsa:3765.
UCSCi uc001fuy.1. human.

Organism-specific databases

CTDi 3765.
GeneCardsi GC01P160051.
H-InvDB HIX0028866.
HGNCi HGNC:6270. KCNJ9.
MIMi 600932. gene.
neXtProti NX_Q92806.
PharmGKBi PA30051.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG72812.
GeneTreei ENSGT00760000118842.
HOGENOMi HOG000237325.
HOVERGENi HBG006178.
InParanoidi Q92806.
KOi K05002.
OMAi DYASFHQ.
OrthoDBi EOG7XPZ5K.
PhylomeDBi Q92806.
TreeFami TF313676.

Enzyme and pathway databases

Reactomei REACT_25004. Inhibition of voltage gated Ca2+ channels via Gbeta/gamma subunits.
REACT_75831. Activation of G protein gated Potassium channels.

Miscellaneous databases

GeneWikii KCNJ9.
GenomeRNAii 3765.
NextBioi 14763.
PROi Q92806.
SOURCEi Search...

Gene expression databases

Bgeei Q92806.
CleanExi HS_KCNJ9.
Genevestigatori Q92806.

Family and domain databases

Gene3Di 2.60.40.1400. 1 hit.
InterProi IPR014756. Ig_E-set.
IPR016449. K_chnl_inward-rec_Kir.
IPR003276. K_chnl_inward-rec_Kir3.3.
IPR013518. K_chnl_inward-rec_Kir_cyto.
[Graphical view ]
PANTHERi PTHR11767. PTHR11767. 1 hit.
PTHR11767:SF17. PTHR11767:SF17. 1 hit.
Pfami PF01007. IRK. 1 hit.
[Graphical view ]
PIRSFi PIRSF005465. GIRK_kir. 1 hit.
PRINTSi PR01329. KIR33CHANNEL.
PR01320. KIRCHANNEL.
SUPFAMi SSF81296. SSF81296. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Co-expression of human Kir3 subunits can yield channels with different functional properties."
    Schoots O., Wilson J.M., Ethier N., Bigras E., Hebert T.E., Van Tol H.H.M.
    Cell. Signal. 11:871-883(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT VAL-366.
  2. "Genomic structure and expression of human KCNJ9 (Kir3.3/GIRK3)."
    Vaughn J., Wolford J.K., Prochazka M., Permana P.A.
    Biochem. Biophys. Res. Commun. 274:302-309(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT VAL-366.
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKCNJ9_HUMAN
AccessioniPrimary (citable) accession number: Q92806
Secondary accession number(s): Q5JW75
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 6, 2007
Last modified: October 29, 2014
This is version 133 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3