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Protein

Golgin subfamily A member 1

Gene

GOLGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Involved in vesicular trafficking at the Golgi apparatus level. Involved in endosome-to-Golgi trafficking.1 Publication

Miscellaneous

Antibodies against GOLGA1 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.1 Publication

Enzyme and pathway databases

ReactomeiR-HSA-6811440 Retrograde transport at the Trans-Golgi-Network

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 1
Alternative name(s):
Golgin-97
Gene namesi
Name:GOLGA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

EuPathDBiHostDB:ENSG00000136935.13
HGNCiHGNC:4424 GOLGA1
MIMi602502 gene
neXtProtiNX_Q92805

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasmic vesicle, Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi2F → A: Loss of TBC1D23-binding. 1 Publication1
Mutagenesisi4K → A: No effect on TBC1D23-binding. 1 Publication1
Mutagenesisi5L → A: Loss of TBC1D23-binding. 1 Publication1
Mutagenesisi6K → A: Decreased TBC1D23-binding. 1 Publication1
Mutagenesisi7K → A: No effect on TBC1D23-binding. 1 Publication1
Mutagenesisi8K → A: No effect on TBC1D23-binding. 1 Publication1
Mutagenesisi9I → A: Decreased TBC1D23-binding. 1 Publication1
Mutagenesisi11E → A: No effect on TBC1D23-binding. 1 Publication1
Mutagenesisi12E → A: No effect on TBC1D23-binding. 1 Publication1
Mutagenesisi695F → A: No effect on RAB6A-binding, nor on targeting to the Golgi apparatus. 1 Publication1
Mutagenesisi696E → A: No effect on RAB6A-binding, nor on targeting to the Golgi apparatus. 1 Publication1
Mutagenesisi697Y → A: Loss of RAB6A-binding and of targeting to the Golgi apparatus. 1 Publication1
Mutagenesisi698L → A: No effect on RAB6A-binding, nor on targeting to the Golgi apparatus. 1 Publication1
Mutagenesisi742M → A: No effect on subcellular localization at the Golgi apparatus. 1 Publication1
Mutagenesisi743S → A: No effect on subcellular localization at the Golgi apparatus, small decrease in RAB6A-binding. 1 Publication1
Mutagenesisi744W → A: Drastically reduced targeting to the Golgi apparatus, small decrease in RAB6A-binding. 1 Publication1

Organism-specific databases

DisGeNETi2800
OpenTargetsiENSG00000136935
PharmGKBiPA28804

Polymorphism and mutation databases

BioMutaiGOLGA1
DMDMi311033445

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001900521 – 767Golgin subfamily A member 1Add BLAST767

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphoserineBy similarity1
Modified residuei36PhosphoserineBy similarity1
Modified residuei41PhosphoserineCombined sources1
Modified residuei47PhosphoserineBy similarity1
Modified residuei50PhosphoserineCombined sources1
Modified residuei51PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92805
MaxQBiQ92805
PaxDbiQ92805
PeptideAtlasiQ92805
PRIDEiQ92805

2D gel databases

UCD-2DPAGEiQ92805

PTM databases

iPTMnetiQ92805
PhosphoSitePlusiQ92805

Expressioni

Gene expression databases

BgeeiENSG00000136935
CleanExiHS_GOLGA1
ExpressionAtlasiQ92805 baseline and differential
GenevisibleiQ92805 HS

Organism-specific databases

HPAiCAB013065
HPA044329
HPA050555

Interactioni

Subunit structurei

Interacts with RAB6A (PubMed:10209123). Directly interacts with TBC1D23 (PubMed:29084197). Interacts with FAM91A1; this interaction may mediated by TBC1D23 (PubMed:29084197).2 Publications

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi109062, 19 interactors
IntActiQ92805, 22 interactors
MINTiQ92805
STRINGi9606.ENSP00000362656

Structurei

3D structure databases

ProteinModelPortaliQ92805
SMRiQ92805
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini688 – 737GRIPPROSITE-ProRule annotationAdd BLAST50

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili50 – 657Sequence analysisAdd BLAST608

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi361 – 546Gln-richAdd BLAST186

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG17 Eukaryota
ENOG410ZJU1 LUCA
GeneTreeiENSGT00530000064371
HOGENOMiHOG000246957
HOVERGENiHBG051751
InParanoidiQ92805
KOiK16731
OMAiHVIVKFL
OrthoDBiEOG091G02ME
PhylomeDBiQ92805
TreeFamiTF326001

Family and domain databases

InterProiView protein in InterPro
IPR000237 GRIP_dom
PfamiView protein in Pfam
PF01465 GRIP, 1 hit
SMARTiView protein in SMART
SM00755 Grip, 1 hit
PROSITEiView protein in PROSITE
PS50913 GRIP, 1 hit

Sequencei

Sequence statusi: Complete.

Q92805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKLKKKIA EETAVAQRPG GATRIPRSVS KESVASMGAD SGDDFASDGS
60 70 80 90 100
SSREDLSSQL LRRNEQIRKL EARLSDYAEQ VRNLQKIKEK LEIALEKHQD
110 120 130 140 150
SSMRKFQEQN ETFQANRAKM AEGLALALAR KDQEWSEKMD QLEKEKNILT
160 170 180 190 200
AQLQEMKNQS MNLFQRRDEM DELEGFQQQE LSKIKHMLLK KEESLGKMEQ
210 220 230 240 250
ELEARTRELS RTQEELMNSN QMSSDLSQKL EELQRHYSTL EEQRDHVIAS
260 270 280 290 300
KTGAESKITA LEQKEQELQA LIQQLSIDLQ KVTAETQEKE DVITHLQEKV
310 320 330 340 350
ASLEKRLEQN LSGEEHLQEL LKEKTLAEQN LEDTRQQLLA ARSSQAKAIN
360 370 380 390 400
TLETRVRELE QTLQASEEQL QQSKGIVAAQ ETQIQELAAA NQESSHVQQQ
410 420 430 440 450
ALALEQQFLE RTQALEAQIV ALERTRAADQ TTAEQGMRQL EQENAALKEC
460 470 480 490 500
RNEYERSLQN HQFELKKLKE EWSQREIVSV AMAQALEEVR KQREEFQQQA
510 520 530 540 550
ANLTAIIDEK EQNLREKTEV LLQKEQEILQ LERGHNSALL QIHQLQAELE
560 570 580 590 600
ALRTLKAEEA AVVAEQEDLL RLRGPLQAEA LSVNESHVTS RAMQDPVFQL
610 620 630 640 650
PTAGRTPNGE VGAMDLTQLQ KEKQDLEQQL LEKNKTIKQM QQRMLELRKT
660 670 680 690 700
LQKELKIRPD NELFEVREKP GPEMANMAPS VTNNTDLTDA REINFEYLKH
710 720 730 740 750
VVLKFMSCRE SEAFHLIKAV SVLLNFSQEE ENMLKETLEY KMSWFGSKPA
760
PKGSIRPSIS NPRIPWS
Length:767
Mass (Da):88,184
Last modified:November 2, 2010 - v3
Checksum:i8E235EAA92D6C61F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_047842220N → S. Corresponds to variant dbSNP:rs35237091Ensembl.1
Natural variantiVAR_047843317L → V2 PublicationsCorresponds to variant dbSNP:rs583134Ensembl.1
Natural variantiVAR_047844425T → M1 PublicationCorresponds to variant dbSNP:rs634710Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51587 mRNA Translation: AAB81549.1
AL451125 Genomic DNA No translation available.
AL354928 Genomic DNA No translation available.
BC032853 mRNA Translation: AAH32853.1
CCDSiCCDS6860.1
RefSeqiNP_002068.1, NM_002077.3
XP_005251986.1, XM_005251929.3
XP_006717125.1, XM_006717062.3
XP_006717126.1, XM_006717063.3
UniGeneiHs.133469
Hs.59504

Genome annotation databases

EnsembliENST00000373555; ENSP00000362656; ENSG00000136935
GeneIDi2800
KEGGihsa:2800
UCSCiuc004bpc.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiGOGA1_HUMAN
AccessioniPrimary (citable) accession number: Q92805
Secondary accession number(s): Q5T164, Q8IYZ9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 2, 2010
Last modified: March 28, 2018
This is version 145 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health