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Protein

Golgin subfamily A member 1

Gene

GOLGA1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably involved in maintaining Golgi structure.1 Publication

GO - Biological processi

Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Names & Taxonomyi

Protein namesi
Recommended name:
Golgin subfamily A member 1
Alternative name(s):
Golgin-97
Gene namesi
Name:GOLGA1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:4424. GOLGA1.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi697 – 6971Y → A: Abolishes interaction with RAB6A and targeting to Golgi stack. 1 Publication
Mutagenesisi744 – 7441W → A: Reduces targeting to Golgi stack. 1 Publication

Organism-specific databases

PharmGKBiPA28804.

Polymorphism and mutation databases

BioMutaiGOLGA1.
DMDMi311033445.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 767767Golgin subfamily A member 1PRO_0000190052Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphoserineBy similarity
Modified residuei36 – 361PhosphoserineBy similarity
Modified residuei41 – 411PhosphoserineCombined sources
Modified residuei47 – 471PhosphoserineBy similarity
Modified residuei50 – 501PhosphoserineCombined sources
Modified residuei51 – 511PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92805.
MaxQBiQ92805.
PaxDbiQ92805.
PeptideAtlasiQ92805.
PRIDEiQ92805.

2D gel databases

UCD-2DPAGEQ92805.

PTM databases

iPTMnetiQ92805.
PhosphoSiteiQ92805.

Expressioni

Gene expression databases

BgeeiENSG00000136935.
CleanExiHS_GOLGA1.
ExpressionAtlasiQ92805. baseline and differential.
GenevisibleiQ92805. HS.

Organism-specific databases

HPAiCAB013065.
HPA044329.
HPA050555.

Interactioni

Subunit structurei

Binds RAB6A.

Binary interactionsi

WithEntry#Exp.IntActNotes
ATF4P188483EBI-6164177,EBI-492498
ATF4Q96AQ33EBI-6164177,EBI-740263
CEP57L1Q8IYX8-23EBI-6164177,EBI-10181988
TFIP11Q9UBB93EBI-6164177,EBI-1105213
VPS52Q8N1B43EBI-6164177,EBI-2799833

Protein-protein interaction databases

BioGridi109062. 17 interactions.
IntActiQ92805. 13 interactions.
STRINGi9606.ENSP00000362656.

Structurei

3D structure databases

ProteinModelPortaliQ92805.
SMRiQ92805. Positions 692-747.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini688 – 73750GRIPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili50 – 657608Sequence analysisAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi361 – 546186Gln-richAdd
BLAST

Domaini

Extended rod-like protein with coiled-coil domains.

Sequence similaritiesi

Contains 1 GRIP domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IG17. Eukaryota.
ENOG410ZJU1. LUCA.
GeneTreeiENSGT00530000064371.
HOGENOMiHOG000246957.
HOVERGENiHBG051751.
InParanoidiQ92805.
KOiK16731.
OMAiQMHQLQA.
OrthoDBiEOG091G02ME.
PhylomeDBiQ92805.
TreeFamiTF326001.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92805-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MFAKLKKKIA EETAVAQRPG GATRIPRSVS KESVASMGAD SGDDFASDGS
60 70 80 90 100
SSREDLSSQL LRRNEQIRKL EARLSDYAEQ VRNLQKIKEK LEIALEKHQD
110 120 130 140 150
SSMRKFQEQN ETFQANRAKM AEGLALALAR KDQEWSEKMD QLEKEKNILT
160 170 180 190 200
AQLQEMKNQS MNLFQRRDEM DELEGFQQQE LSKIKHMLLK KEESLGKMEQ
210 220 230 240 250
ELEARTRELS RTQEELMNSN QMSSDLSQKL EELQRHYSTL EEQRDHVIAS
260 270 280 290 300
KTGAESKITA LEQKEQELQA LIQQLSIDLQ KVTAETQEKE DVITHLQEKV
310 320 330 340 350
ASLEKRLEQN LSGEEHLQEL LKEKTLAEQN LEDTRQQLLA ARSSQAKAIN
360 370 380 390 400
TLETRVRELE QTLQASEEQL QQSKGIVAAQ ETQIQELAAA NQESSHVQQQ
410 420 430 440 450
ALALEQQFLE RTQALEAQIV ALERTRAADQ TTAEQGMRQL EQENAALKEC
460 470 480 490 500
RNEYERSLQN HQFELKKLKE EWSQREIVSV AMAQALEEVR KQREEFQQQA
510 520 530 540 550
ANLTAIIDEK EQNLREKTEV LLQKEQEILQ LERGHNSALL QIHQLQAELE
560 570 580 590 600
ALRTLKAEEA AVVAEQEDLL RLRGPLQAEA LSVNESHVTS RAMQDPVFQL
610 620 630 640 650
PTAGRTPNGE VGAMDLTQLQ KEKQDLEQQL LEKNKTIKQM QQRMLELRKT
660 670 680 690 700
LQKELKIRPD NELFEVREKP GPEMANMAPS VTNNTDLTDA REINFEYLKH
710 720 730 740 750
VVLKFMSCRE SEAFHLIKAV SVLLNFSQEE ENMLKETLEY KMSWFGSKPA
760
PKGSIRPSIS NPRIPWS
Length:767
Mass (Da):88,184
Last modified:November 2, 2010 - v3
Checksum:i8E235EAA92D6C61F
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti220 – 2201N → S.
Corresponds to variant rs35237091 [ dbSNP | Ensembl ].
VAR_047842
Natural varianti317 – 3171L → V.2 Publications
Corresponds to variant rs583134 [ dbSNP | Ensembl ].
VAR_047843
Natural varianti425 – 4251T → M.1 Publication
Corresponds to variant rs634710 [ dbSNP | Ensembl ].
VAR_047844

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51587 mRNA. Translation: AAB81549.1.
AL451125, AL354928 Genomic DNA. Translation: CAI14346.1.
AL354928, AL451125 Genomic DNA. Translation: CAI39632.1.
BC032853 mRNA. Translation: AAH32853.1.
CCDSiCCDS6860.1.
RefSeqiNP_002068.1. NM_002077.3.
XP_005251986.1. XM_005251929.3.
XP_006717125.1. XM_006717062.3.
XP_006717126.1. XM_006717063.3.
UniGeneiHs.133469.
Hs.59504.

Genome annotation databases

EnsembliENST00000373555; ENSP00000362656; ENSG00000136935.
GeneIDi2800.
KEGGihsa:2800.
UCSCiuc004bpc.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51587 mRNA. Translation: AAB81549.1.
AL451125, AL354928 Genomic DNA. Translation: CAI14346.1.
AL354928, AL451125 Genomic DNA. Translation: CAI39632.1.
BC032853 mRNA. Translation: AAH32853.1.
CCDSiCCDS6860.1.
RefSeqiNP_002068.1. NM_002077.3.
XP_005251986.1. XM_005251929.3.
XP_006717125.1. XM_006717062.3.
XP_006717126.1. XM_006717063.3.
UniGeneiHs.133469.
Hs.59504.

3D structure databases

ProteinModelPortaliQ92805.
SMRiQ92805. Positions 692-747.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi109062. 17 interactions.
IntActiQ92805. 13 interactions.
STRINGi9606.ENSP00000362656.

PTM databases

iPTMnetiQ92805.
PhosphoSiteiQ92805.

Polymorphism and mutation databases

BioMutaiGOLGA1.
DMDMi311033445.

2D gel databases

UCD-2DPAGEQ92805.

Proteomic databases

EPDiQ92805.
MaxQBiQ92805.
PaxDbiQ92805.
PeptideAtlasiQ92805.
PRIDEiQ92805.

Protocols and materials databases

DNASUi2800.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000373555; ENSP00000362656; ENSG00000136935.
GeneIDi2800.
KEGGihsa:2800.
UCSCiuc004bpc.4. human.

Organism-specific databases

CTDi2800.
GeneCardsiGOLGA1.
HGNCiHGNC:4424. GOLGA1.
HPAiCAB013065.
HPA044329.
HPA050555.
MIMi602502. gene.
neXtProtiNX_Q92805.
PharmGKBiPA28804.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IG17. Eukaryota.
ENOG410ZJU1. LUCA.
GeneTreeiENSGT00530000064371.
HOGENOMiHOG000246957.
HOVERGENiHBG051751.
InParanoidiQ92805.
KOiK16731.
OMAiQMHQLQA.
OrthoDBiEOG091G02ME.
PhylomeDBiQ92805.
TreeFamiTF326001.

Enzyme and pathway databases

ReactomeiR-HSA-6811440. Retrograde transport at the Trans-Golgi-Network.

Miscellaneous databases

ChiTaRSiGOLGA1. human.
GeneWikiiGOLGA1.
GenomeRNAii2800.
PROiQ92805.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000136935.
CleanExiHS_GOLGA1.
ExpressionAtlasiQ92805. baseline and differential.
GenevisibleiQ92805. HS.

Family and domain databases

Gene3Di1.10.220.60. 1 hit.
InterProiIPR000237. GRIP_dom.
[Graphical view]
PfamiPF01465. GRIP. 1 hit.
[Graphical view]
SMARTiSM00755. Grip. 1 hit.
[Graphical view]
PROSITEiPS50913. GRIP. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiGOGA1_HUMAN
AccessioniPrimary (citable) accession number: Q92805
Secondary accession number(s): Q5T164, Q8IYZ9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: November 2, 2010
Last modified: September 7, 2016
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

Antibodies against GOLGA1 are present in sera from patients with Sjoegren syndrome. Sera from patients with Sjoegren syndrome often contain antibodies that react with normal components of the Golgi complex.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.