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Q92804

- RBP56_HUMAN

UniProt

Q92804 - RBP56_HUMAN

Protein

TATA-binding protein-associated factor 2N

Gene

TAF15

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 155 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).1 Publication

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri354 – 38532RanBP2-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. nucleotide binding Source: InterPro
    3. poly(A) RNA binding Source: UniProtKB
    4. protein binding Source: UniProtKB
    5. zinc ion binding Source: InterPro

    GO - Biological processi

    1. positive regulation of transcription, DNA-templated Source: UniProtKB

    Keywords - Ligandi

    DNA-binding, Metal-binding, RNA-binding, Zinc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    TATA-binding protein-associated factor 2N
    Alternative name(s):
    68 kDa TATA-binding protein-associated factor
    Short name:
    TAF(II)68
    Short name:
    TAFII68
    RNA-binding protein 56
    Gene namesi
    Name:TAF15
    Synonyms:RBP56, TAF2N
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:11547. TAF15.

    Subcellular locationi

    Nucleus 1 Publication. Cytoplasm 1 Publication
    Note: Shuttles from the nucleus to the cytoplasm.

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Involvement in diseasei

    A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.

    Keywords - Diseasei

    Proto-oncogene

    Organism-specific databases

    Orphaneti803. Amyotrophic lateral sclerosis.
    209916. Extraskeletal myxoid chondrosarcoma.
    PharmGKBiPA36322.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 592592TATA-binding protein-associated factor 2NPRO_0000081749Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei206 – 2061Asymmetric dimethylarginine; by PRMT12 Publications
    Modified residuei226 – 2261Phosphoserine1 Publication
    Modified residuei231 – 2311Phosphoserine1 Publication
    Modified residuei268 – 2681N6-acetyllysine1 Publication
    Modified residuei423 – 4231Phosphoserine1 Publication
    Modified residuei438 – 4381Phosphoserine1 Publication
    Modified residuei442 – 4421Phosphoserine1 Publication
    Modified residuei451 – 4511Phosphoserine1 Publication
    Modified residuei483 – 4831Dimethylated arginine1 Publication
    Modified residuei528 – 5281Asymmetric dimethylarginine; by PRMT11 Publication
    Modified residuei535 – 5351Asymmetric dimethylarginine; by PRMT11 Publication
    Modified residuei554 – 5541Phosphoserine1 Publication
    Modified residuei570 – 5701Asymmetric dimethylarginine2 Publications
    Modified residuei570 – 5701Asymmetric dimethylarginine; by PRMT12 Publications

    Post-translational modificationi

    Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.2 Publications
    ADP-ribosylated during genotoxic stress.

    Keywords - PTMi

    Acetylation, ADP-ribosylation, Methylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92804.
    PaxDbiQ92804.
    PRIDEiQ92804.

    PTM databases

    PhosphoSiteiQ92804.

    Miscellaneous databases

    PMAP-CutDBQ92804.

    Expressioni

    Tissue specificityi

    Ubiquitous. Observed in all fetal and adult tissues.

    Gene expression databases

    ArrayExpressiQ92804.
    BgeeiQ92804.
    CleanExiHS_TAF15.
    GenevestigatoriQ92804.

    Organism-specific databases

    HPAiHPA052059.

    Interactioni

    Subunit structurei

    Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    FUSP356375EBI-2255091,EBI-400434

    Protein-protein interaction databases

    BioGridi113807. 53 interactions.
    DIPiDIP-52760N.
    IntActiQ92804. 21 interactions.
    MINTiMINT-3049394.
    STRINGi9606.ENSP00000309558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92804.
    SMRiQ92804. Positions 232-319.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini234 – 32087RRMPROSITE-ProRule annotationAdd
    BLAST
    Repeati407 – 41371
    Repeati414 – 42072
    Repeati421 – 42993
    Repeati430 – 439104
    Repeati440 – 44895
    Repeati449 – 45796
    Repeati458 – 46587
    Repeati466 – 47388
    Repeati474 – 48189
    Repeati482 – 488710
    Repeati489 – 496811
    Repeati497 – 503712
    Repeati504 – 510713
    Repeati511 – 517714
    Repeati518 – 524715
    Repeati525 – 533916
    Repeati534 – 5431017
    Repeati544 – 551818
    Repeati552 – 560919
    Repeati561 – 568820
    Repeati569 – 575721

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni407 – 57516921 X approximate tandem repeats of D-R-[S,G](0,3)-G-G-Y-G-GAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi1 – 208208Gln/Gly/Ser/Tyr-richAdd
    BLAST
    Compositional biasi320 – 590271Arg/Gly-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the RRM TET family.Curated
    Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
    Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri354 – 38532RanBP2-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Repeat, Zinc-finger

    Phylogenomic databases

    eggNOGiNOG240581.
    HOGENOMiHOG000038010.
    HOVERGENiHBG005755.
    InParanoidiQ92804.
    KOiK14651.
    OMAiQKQSSYS.
    OrthoDBiEOG7DZ8N7.
    PhylomeDBiQ92804.

    Family and domain databases

    Gene3Di3.30.70.330. 1 hit.
    4.10.1060.10. 1 hit.
    InterProiIPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR001876. Znf_RanBP2.
    [Graphical view]
    PfamiPF00076. RRM_1. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view]
    SMARTiSM00360. RRM. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view]
    PROSITEiPS50102. RRM. 1 hit.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Long (identifier: Q92804-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MSDSGSYGQS GGEQQSYSTY GNPGSQGYGQ ASQSYSGYGQ TTDSSYGQNY    50
    SGYSSYGQSQ SGYSQSYGGY ENQKQSSYSQ QPYNNQGQQQ NMESSGSQGG 100
    RAPSYDQPDY GQQDSYDQQS GYDQHQGSYD EQSNYDQQHD SYSQNQQSYH 150
    SQRENYSHHT QDDRRDVSRY GEDNRGYGGS QGGGRGRGGY DKDGRGPMTG 200
    SSGGDRGGFK NFGGHRDYGP RTDADSESDN SDNNTIFVQG LGEGVSTDQV 250
    GEFFKQIGII KTNKKTGKPM INLYTDKDTG KPKGEATVSF DDPPSAKAAI 300
    DWFDGKEFHG NIIKVSFATR RPEFMRGGGS GGGRRGRGGY RGRGGFQGRG 350
    GDPKSGDWVC PNPSCGNMNF ARRNSCNQCN EPRPEDSRPS GGDFRGRGYG 400
    GERGYRGRGG RGGDRGGYGG DRSGGGYGGD RSSGGGYSGD RSGGGYGGDR 450
    SGGGYGGDRG GGYGGDRGGG YGGDRGGGYG GDRGGYGGDR GGGYGGDRGG 500
    YGGDRGGYGG DRGGYGGDRG GYGGDRSRGG YGGDRGGGSG YGGDRSGGYG 550
    GDRSGGGYGG DRGGGYGGDR GGYGGKMGGR NDYRNDQRNR PY 592
    Length:592
    Mass (Da):61,830
    Last modified:February 1, 1997 - v1
    Checksum:i73D37C171E1E2BCA
    GO
    Isoform Short (identifier: Q92804-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         60-62: Missing.

    Show »
    Length:589
    Mass (Da):61,558
    Checksum:i5D24CA4BF574824A
    GO

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei60 – 623Missing in isoform Short. 3 PublicationsVSP_005806

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51334 mRNA. Translation: AAC50932.1.
    X98893 mRNA. Translation: CAA67398.1.
    AB010067 Genomic DNA. Translation: BAA33811.1.
    AB010067 Genomic DNA. Translation: BAA33812.1.
    AY197697 Genomic DNA. Translation: AAO13485.1.
    AK313223 mRNA. Translation: BAG36034.1.
    AK314194 mRNA. Translation: BAG36873.1.
    AC015849 Genomic DNA. No translation available.
    CH471147 Genomic DNA. Translation: EAW80124.1.
    CH471147 Genomic DNA. Translation: EAW80125.1.
    BC046099 mRNA. Translation: AAH46099.2.
    CCDSiCCDS32623.1. [Q92804-1]
    CCDS59279.1. [Q92804-2]
    PIRiS71954.
    RefSeqiNP_003478.1. NM_003487.3. [Q92804-2]
    NP_631961.1. NM_139215.2. [Q92804-1]
    UniGeneiHs.402752.

    Genome annotation databases

    EnsembliENST00000604841; ENSP00000474609; ENSG00000270647. [Q92804-2]
    ENST00000605844; ENSP00000474096; ENSG00000270647. [Q92804-1]
    GeneIDi8148.
    KEGGihsa:8148.
    UCSCiuc002hkc.4. human. [Q92804-2]
    uc002hkd.4. human. [Q92804-1]

    Polymorphism databases

    DMDMi8928305.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology
    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U51334 mRNA. Translation: AAC50932.1 .
    X98893 mRNA. Translation: CAA67398.1 .
    AB010067 Genomic DNA. Translation: BAA33811.1 .
    AB010067 Genomic DNA. Translation: BAA33812.1 .
    AY197697 Genomic DNA. Translation: AAO13485.1 .
    AK313223 mRNA. Translation: BAG36034.1 .
    AK314194 mRNA. Translation: BAG36873.1 .
    AC015849 Genomic DNA. No translation available.
    CH471147 Genomic DNA. Translation: EAW80124.1 .
    CH471147 Genomic DNA. Translation: EAW80125.1 .
    BC046099 mRNA. Translation: AAH46099.2 .
    CCDSi CCDS32623.1. [Q92804-1 ]
    CCDS59279.1. [Q92804-2 ]
    PIRi S71954.
    RefSeqi NP_003478.1. NM_003487.3. [Q92804-2 ]
    NP_631961.1. NM_139215.2. [Q92804-1 ]
    UniGenei Hs.402752.

    3D structure databases

    ProteinModelPortali Q92804.
    SMRi Q92804. Positions 232-319.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 113807. 53 interactions.
    DIPi DIP-52760N.
    IntActi Q92804. 21 interactions.
    MINTi MINT-3049394.
    STRINGi 9606.ENSP00000309558.

    PTM databases

    PhosphoSitei Q92804.

    Polymorphism databases

    DMDMi 8928305.

    Proteomic databases

    MaxQBi Q92804.
    PaxDbi Q92804.
    PRIDEi Q92804.

    Protocols and materials databases

    DNASUi 8148.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000604841 ; ENSP00000474609 ; ENSG00000270647 . [Q92804-2 ]
    ENST00000605844 ; ENSP00000474096 ; ENSG00000270647 . [Q92804-1 ]
    GeneIDi 8148.
    KEGGi hsa:8148.
    UCSCi uc002hkc.4. human. [Q92804-2 ]
    uc002hkd.4. human. [Q92804-1 ]

    Organism-specific databases

    CTDi 8148.
    GeneCardsi GC17P034136.
    HGNCi HGNC:11547. TAF15.
    HPAi HPA052059.
    MIMi 601574. gene.
    neXtProti NX_Q92804.
    Orphaneti 803. Amyotrophic lateral sclerosis.
    209916. Extraskeletal myxoid chondrosarcoma.
    PharmGKBi PA36322.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG240581.
    HOGENOMi HOG000038010.
    HOVERGENi HBG005755.
    InParanoidi Q92804.
    KOi K14651.
    OMAi QKQSSYS.
    OrthoDBi EOG7DZ8N7.
    PhylomeDBi Q92804.

    Miscellaneous databases

    ChiTaRSi TAF15. human.
    GeneWikii TAF15.
    GenomeRNAii 8148.
    NextBioi 30819.
    PMAP-CutDB Q92804.
    PROi Q92804.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92804.
    Bgeei Q92804.
    CleanExi HS_TAF15.
    Genevestigatori Q92804.

    Family and domain databases

    Gene3Di 3.30.70.330. 1 hit.
    4.10.1060.10. 1 hit.
    InterProi IPR012677. Nucleotide-bd_a/b_plait.
    IPR000504. RRM_dom.
    IPR001876. Znf_RanBP2.
    [Graphical view ]
    Pfami PF00076. RRM_1. 1 hit.
    PF00641. zf-RanBP. 1 hit.
    [Graphical view ]
    SMARTi SM00360. RRM. 1 hit.
    SM00547. ZnF_RBZ. 1 hit.
    [Graphical view ]
    PROSITEi PS50102. RRM. 1 hit.
    PS01358. ZF_RANBP2_1. 1 hit.
    PS50199. ZF_RANBP2_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and mapping of a human RBP56 gene encoding a putative RNA binding protein similar to FUS/TLS and EWS proteins."
      Morohoshi F., Arai K., Takahashi E., Tanigami A., Ohki M.
      Genomics 38:51-57(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS LONG AND SHORT).
    2. "hTAF(II)68, a novel RNA/ssDNA-binding protein with homology to the pro-oncoproteins TLS/FUS and EWS is associated with both TFIID and RNA polymerase II."
      Bertolotti A., Lutz Y., Heard D.J., Chambon P., Tora L.
      EMBO J. 15:5022-5031(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM SHORT), PROTEIN SEQUENCE OF 282-297 AND 307-320.
    3. "Genomic structure of the human RBP56/hTAFII68 and FUS/TLS genes."
      Morohoshi F., Ootsuka Y., Arai K., Ichikawa H., Mitani S., Munakata N., Ohki M.
      Gene 221:191-198(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] (ISOFORMS LONG AND SHORT).
    4. NIEHS SNPs program
      Submitted (DEC-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS SHORT AND LONG).
      Tissue: Tongue.
    6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM LONG).
      Tissue: Testis.
    9. Bienvenut W.V., Lilla S., von Kriegsheim A., Lempens A., Kolch W.
      Submitted (DEC-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 75-101; 196-210; 284-306; 476-490 AND 563-576, METHYLATION AT ARG-206; ARG-483 AND ARG-570, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Ovarian carcinoma.
    10. "The transcriptional repressor ZFM1 interacts with and modulates the ability of EWS to activate transcription."
      Zhang D., Paley A.J., Childs G.
      J. Biol. Chem. 273:18086-18091(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH SF1.
    11. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Embryonic kidney.
    12. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    13. "PRMT1 mediated methylation of TAF15 is required for its positive gene regulatory function."
      Jobert L., Argentini M., Tora L.
      Exp. Cell Res. 315:1273-1286(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, METHYLATION AT ARG-206; ARG-528; ARG-535 AND ARG-570 BY PRMT1, IDENTIFICATION BY MASS SPECTROMETRY, SUBCELLULAR LOCATION.
    14. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-226 AND SER-231, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    15. "Lysine acetylation targets protein complexes and co-regulates major cellular functions."
      Choudhary C., Kumar C., Gnad F., Nielsen M.L., Rehman M., Walther T.C., Olsen J.V., Mann M.
      Science 325:834-840(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT LYS-268, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    16. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    17. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-423; SER-438; SER-442; SER-451 AND SER-554, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    18. "Proteome-wide identification of poly(ADP-Ribosyl)ation targets in different genotoxic stress responses."
      Jungmichel S., Rosenthal F., Altmeyer M., Lukas J., Hottiger M.O., Nielsen M.L.
      Mol. Cell 52:272-285(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: ADP-RIBOSYLATION.

    Entry informationi

    Entry nameiRBP56_HUMAN
    AccessioniPrimary (citable) accession number: Q92804
    Secondary accession number(s): B2R837, Q86X94, Q92751
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 1, 2000
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 155 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3