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Protein

TATA-binding protein-associated factor 2N

Gene

TAF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri354 – 385RanBP2-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

  • DNA binding Source: UniProtKB-KW
  • nucleotide binding Source: InterPro
  • poly(A) RNA binding Source: UniProtKB
  • zinc ion binding Source: InterPro

GO - Biological processi

  • positive regulation of transcription, DNA-templated Source: UniProtKB
Complete GO annotation...

Keywords - Ligandi

DNA-binding, Metal-binding, RNA-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172660-MONOMER.
SIGNORiQ92804.

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-binding protein-associated factor 2N
Alternative name(s):
68 kDa TATA-binding protein-associated factor
Short name:
TAF(II)68
Short name:
TAFII68
RNA-binding protein 56
Gene namesi
Name:TAF15
Synonyms:RBP56, TAF2N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:11547. TAF15.

Subcellular locationi

  • Nucleus 1 Publication
  • Cytoplasm 1 Publication

  • Note: Shuttles from the nucleus to the cytoplasm.

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8148.
MalaCardsiTAF15.
OpenTargetsiENSG00000270647.
ENSG00000276833.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBiPA36322.

Polymorphism and mutation databases

BioMutaiTAF15.
DMDMi8928305.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817491 – 592TATA-binding protein-associated factor 2NAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206Asymmetric dimethylarginine; by PRMT1; alternate2 Publications1
Modified residuei206Omega-N-methylarginine; alternateCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Modified residuei268N6-acetyllysineCombined sources1
Modified residuei375PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei431Omega-N-methylarginineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Modified residuei459Omega-N-methylarginineCombined sources1
Modified residuei475Omega-N-methylarginineCombined sources1
Modified residuei483Dimethylated arginine1 Publication1
Modified residuei528Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei535Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei554PhosphoserineCombined sources1
Modified residuei562Omega-N-methylarginineCombined sources1
Modified residuei570Asymmetric dimethylarginine2 Publications1
Modified residuei570Asymmetric dimethylarginine; by PRMT12 Publications1

Post-translational modificationi

Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.2 Publications
ADP-ribosylated during genotoxic stress.

Keywords - PTMi

Acetylation, ADP-ribosylation, Methylation, Phosphoprotein

Proteomic databases

EPDiQ92804.
MaxQBiQ92804.
PaxDbiQ92804.
PeptideAtlasiQ92804.
PRIDEiQ92804.

PTM databases

iPTMnetiQ92804.
PhosphoSitePlusiQ92804.
SwissPalmiQ92804.

Miscellaneous databases

PMAP-CutDBQ92804.

Expressioni

Tissue specificityi

Ubiquitous. Observed in all fetal and adult tissues.

Gene expression databases

BgeeiENSG00000172660.
CleanExiHS_TAF15.
ExpressionAtlasiQ92804. baseline and differential.
GenevisibleiQ92804. HS.

Organism-specific databases

HPAiHPA052059.
HPA063647.

Interactioni

Subunit structurei

Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

Binary interactionsi

WithEntry#Exp.IntActNotes
FUSP356375EBI-2255091,EBI-400434

Protein-protein interaction databases

BioGridi113807. 67 interactors.
DIPiDIP-52760N.
IntActiQ92804. 31 interactors.
MINTiMINT-3049394.
STRINGi9606.ENSP00000466950.

Structurei

Secondary structure

1592
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi236 – 240Combined sources5
Helixi250 – 255Combined sources6
Turni264 – 266Combined sources3
Beta strandi272 – 274Combined sources3
Turni277 – 279Combined sources3
Beta strandi285 – 288Combined sources4
Helixi293 – 301Combined sources9
Beta strandi304 – 308Combined sources5
Beta strandi314 – 316Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MMYNMR-A231-323[»]
ProteinModelPortaliQ92804.
SMRiQ92804.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 320RRMPROSITE-ProRule annotationAdd BLAST87
Repeati407 – 41317
Repeati414 – 42027
Repeati421 – 42939
Repeati430 – 439410
Repeati440 – 44859
Repeati449 – 45769
Repeati458 – 46578
Repeati466 – 47388
Repeati474 – 48198
Repeati482 – 488107
Repeati489 – 496118
Repeati497 – 503127
Repeati504 – 510137
Repeati511 – 517147
Repeati518 – 524157
Repeati525 – 533169
Repeati534 – 5431710
Repeati544 – 551188
Repeati552 – 560199
Repeati561 – 568208
Repeati569 – 575217

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni407 – 57521 X approximate tandem repeats of D-R-[S,G](0,3)-G-G-Y-G-GAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 208Gln/Gly/Ser/Tyr-richAdd BLAST208
Compositional biasi320 – 590Arg/Gly-richAdd BLAST271

Sequence similaritiesi

Belongs to the RRM TET family.Curated
Contains 1 RanBP2-type zinc finger.PROSITE-ProRule annotation
Contains 1 RRM (RNA recognition motif) domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri354 – 385RanBP2-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IP57. Eukaryota.
ENOG4111P4G. LUCA.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG005755.
InParanoidiQ92804.
KOiK14651.
OMAiSYSTYGN.
OrthoDBiEOG091G0U8W.
PhylomeDBiQ92804.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q92804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSGSYGQS GGEQQSYSTY GNPGSQGYGQ ASQSYSGYGQ TTDSSYGQNY
60 70 80 90 100
SGYSSYGQSQ SGYSQSYGGY ENQKQSSYSQ QPYNNQGQQQ NMESSGSQGG
110 120 130 140 150
RAPSYDQPDY GQQDSYDQQS GYDQHQGSYD EQSNYDQQHD SYSQNQQSYH
160 170 180 190 200
SQRENYSHHT QDDRRDVSRY GEDNRGYGGS QGGGRGRGGY DKDGRGPMTG
210 220 230 240 250
SSGGDRGGFK NFGGHRDYGP RTDADSESDN SDNNTIFVQG LGEGVSTDQV
260 270 280 290 300
GEFFKQIGII KTNKKTGKPM INLYTDKDTG KPKGEATVSF DDPPSAKAAI
310 320 330 340 350
DWFDGKEFHG NIIKVSFATR RPEFMRGGGS GGGRRGRGGY RGRGGFQGRG
360 370 380 390 400
GDPKSGDWVC PNPSCGNMNF ARRNSCNQCN EPRPEDSRPS GGDFRGRGYG
410 420 430 440 450
GERGYRGRGG RGGDRGGYGG DRSGGGYGGD RSSGGGYSGD RSGGGYGGDR
460 470 480 490 500
SGGGYGGDRG GGYGGDRGGG YGGDRGGGYG GDRGGYGGDR GGGYGGDRGG
510 520 530 540 550
YGGDRGGYGG DRGGYGGDRG GYGGDRSRGG YGGDRGGGSG YGGDRSGGYG
560 570 580 590
GDRSGGGYGG DRGGGYGGDR GGYGGKMGGR NDYRNDQRNR PY
Length:592
Mass (Da):61,830
Last modified:February 1, 1997 - v1
Checksum:i73D37C171E1E2BCA
GO
Isoform Short (identifier: Q92804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-62: Missing.

Show »
Length:589
Mass (Da):61,558
Checksum:i5D24CA4BF574824A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00580660 – 62Missing in isoform Short. 3 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51334 mRNA. Translation: AAC50932.1.
X98893 mRNA. Translation: CAA67398.1.
AB010067 Genomic DNA. Translation: BAA33811.1.
AB010067 Genomic DNA. Translation: BAA33812.1.
AY197697 Genomic DNA. Translation: AAO13485.1.
AK313223 mRNA. Translation: BAG36034.1.
AK314194 mRNA. Translation: BAG36873.1.
AC015849 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80124.1.
CH471147 Genomic DNA. Translation: EAW80125.1.
BC046099 mRNA. Translation: AAH46099.2.
CCDSiCCDS32623.1. [Q92804-1]
CCDS59279.1. [Q92804-2]
PIRiS71954.
RefSeqiNP_003478.1. NM_003487.3. [Q92804-2]
NP_631961.1. NM_139215.2. [Q92804-1]
UniGeneiHs.402752.

Genome annotation databases

EnsembliENST00000604841; ENSP00000474609; ENSG00000270647. [Q92804-2]
ENST00000605844; ENSP00000474096; ENSG00000270647. [Q92804-1]
ENST00000617382; ENSP00000480040; ENSG00000276833. [Q92804-1]
ENST00000631482; ENSP00000488684; ENSG00000276833. [Q92804-2]
GeneIDi8148.
KEGGihsa:8148.
UCSCiuc002hkc.5. human. [Q92804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology
NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51334 mRNA. Translation: AAC50932.1.
X98893 mRNA. Translation: CAA67398.1.
AB010067 Genomic DNA. Translation: BAA33811.1.
AB010067 Genomic DNA. Translation: BAA33812.1.
AY197697 Genomic DNA. Translation: AAO13485.1.
AK313223 mRNA. Translation: BAG36034.1.
AK314194 mRNA. Translation: BAG36873.1.
AC015849 Genomic DNA. No translation available.
CH471147 Genomic DNA. Translation: EAW80124.1.
CH471147 Genomic DNA. Translation: EAW80125.1.
BC046099 mRNA. Translation: AAH46099.2.
CCDSiCCDS32623.1. [Q92804-1]
CCDS59279.1. [Q92804-2]
PIRiS71954.
RefSeqiNP_003478.1. NM_003487.3. [Q92804-2]
NP_631961.1. NM_139215.2. [Q92804-1]
UniGeneiHs.402752.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MMYNMR-A231-323[»]
ProteinModelPortaliQ92804.
SMRiQ92804.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi113807. 67 interactors.
DIPiDIP-52760N.
IntActiQ92804. 31 interactors.
MINTiMINT-3049394.
STRINGi9606.ENSP00000466950.

PTM databases

iPTMnetiQ92804.
PhosphoSitePlusiQ92804.
SwissPalmiQ92804.

Polymorphism and mutation databases

BioMutaiTAF15.
DMDMi8928305.

Proteomic databases

EPDiQ92804.
MaxQBiQ92804.
PaxDbiQ92804.
PeptideAtlasiQ92804.
PRIDEiQ92804.

Protocols and materials databases

DNASUi8148.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000604841; ENSP00000474609; ENSG00000270647. [Q92804-2]
ENST00000605844; ENSP00000474096; ENSG00000270647. [Q92804-1]
ENST00000617382; ENSP00000480040; ENSG00000276833. [Q92804-1]
ENST00000631482; ENSP00000488684; ENSG00000276833. [Q92804-2]
GeneIDi8148.
KEGGihsa:8148.
UCSCiuc002hkc.5. human. [Q92804-1]

Organism-specific databases

CTDi8148.
DisGeNETi8148.
GeneCardsiTAF15.
HGNCiHGNC:11547. TAF15.
HPAiHPA052059.
HPA063647.
MalaCardsiTAF15.
MIMi601574. gene.
neXtProtiNX_Q92804.
OpenTargetsiENSG00000270647.
ENSG00000276833.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
PharmGKBiPA36322.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IP57. Eukaryota.
ENOG4111P4G. LUCA.
GeneTreeiENSGT00530000063105.
HOGENOMiHOG000038010.
HOVERGENiHBG005755.
InParanoidiQ92804.
KOiK14651.
OMAiSYSTYGN.
OrthoDBiEOG091G0U8W.
PhylomeDBiQ92804.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000172660-MONOMER.
SIGNORiQ92804.

Miscellaneous databases

ChiTaRSiTAF15. human.
GeneWikiiTAF15.
GenomeRNAii8148.
PMAP-CutDBQ92804.
PROiQ92804.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000172660.
CleanExiHS_TAF15.
ExpressionAtlasiQ92804. baseline and differential.
GenevisibleiQ92804. HS.

Family and domain databases

Gene3Di3.30.70.330. 1 hit.
4.10.1060.10. 1 hit.
InterProiIPR012677. Nucleotide-bd_a/b_plait.
IPR000504. RRM_dom.
IPR001876. Znf_RanBP2.
[Graphical view]
PfamiPF00076. RRM_1. 1 hit.
PF00641. zf-RanBP. 1 hit.
[Graphical view]
SMARTiSM00360. RRM. 1 hit.
SM00547. ZnF_RBZ. 1 hit.
[Graphical view]
SUPFAMiSSF54928. SSF54928. 1 hit.
SSF90209. SSF90209. 1 hit.
PROSITEiPS50102. RRM. 1 hit.
PS01358. ZF_RANBP2_1. 1 hit.
PS50199. ZF_RANBP2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRBP56_HUMAN
AccessioniPrimary (citable) accession number: Q92804
Secondary accession number(s): B2R837, Q86X94, Q92751
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 177 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.