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Protein

TATA-binding protein-associated factor 2N

Gene

TAF15

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

RNA and ssDNA-binding protein that may play specific roles during transcription initiation at distinct promoters. Can enter the preinitiation complex together with the RNA polymerase II (Pol II).1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri354 – 385RanBP2-typePROSITE-ProRule annotationAdd BLAST32

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, RNA-binding
LigandMetal-binding, Zinc

Enzyme and pathway databases

ReactomeiR-HSA-167161 HIV Transcription Initiation
R-HSA-167162 RNA Polymerase II HIV Promoter Escape
R-HSA-167172 Transcription of the HIV genome
R-HSA-674695 RNA Polymerase II Pre-transcription Events
R-HSA-6804756 Regulation of TP53 Activity through Phosphorylation
R-HSA-73776 RNA Polymerase II Promoter Escape
R-HSA-73779 RNA Polymerase II Transcription Pre-Initiation And Promoter Opening
R-HSA-75953 RNA Polymerase II Transcription Initiation
R-HSA-76042 RNA Polymerase II Transcription Initiation And Promoter Clearance
SIGNORiQ92804

Names & Taxonomyi

Protein namesi
Recommended name:
TATA-binding protein-associated factor 2N
Alternative name(s):
68 kDa TATA-binding protein-associated factor
Short name:
TAF(II)68
Short name:
TAFII68
RNA-binding protein 56
Gene namesi
Name:TAF15
Synonyms:RBP56, TAF2N
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

EuPathDBiHostDB:ENSG00000270647.5
HGNCiHGNC:11547 TAF15
MIMi601574 gene
neXtProtiNX_Q92804

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving TAF15/TAF2N is found in a form of extraskeletal myxoid chondrosarcomas (EMC). Translocation t(9;17)(q22;q11) with NR4A3.1 Publication

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi8148
MalaCardsiTAF15
OpenTargetsiENSG00000270647
Orphaneti209916 Extraskeletal myxoid chondrosarcoma
PharmGKBiPA36322

Polymorphism and mutation databases

BioMutaiTAF15
DMDMi8928305

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000817491 – 592TATA-binding protein-associated factor 2NAdd BLAST592

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei206Asymmetric dimethylarginine; by PRMT1; alternate2 Publications1
Modified residuei206Omega-N-methylarginine; alternateCombined sources1
Modified residuei226PhosphoserineCombined sources1
Modified residuei231PhosphoserineCombined sources1
Cross-linki265Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei268N6-acetyllysine; alternateCombined sources1
Cross-linki268Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2); alternateCombined sources
Modified residuei375PhosphoserineCombined sources1
Modified residuei423PhosphoserineCombined sources1
Modified residuei431Omega-N-methylarginineCombined sources1
Modified residuei433PhosphoserineCombined sources1
Modified residuei438PhosphoserineCombined sources1
Modified residuei442PhosphoserineCombined sources1
Modified residuei451PhosphoserineCombined sources1
Modified residuei459Omega-N-methylarginineCombined sources1
Modified residuei475Omega-N-methylarginineCombined sources1
Modified residuei483Dimethylated arginine1 Publication1
Modified residuei528Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei535Asymmetric dimethylarginine; by PRMT11 Publication1
Modified residuei554PhosphoserineCombined sources1
Modified residuei562Omega-N-methylarginineCombined sources1
Modified residuei570Asymmetric dimethylarginine2 Publications1
Modified residuei570Asymmetric dimethylarginine; by PRMT12 Publications1

Post-translational modificationi

Dimethylated by PRMT1 at Arg-206 to asymmetric dimethylarginine. The methylation may favor nuclear localization and positive regulation of TAF15 transcriptional activity.2 Publications
ADP-ribosylated during genotoxic stress.

Keywords - PTMi

Acetylation, ADP-ribosylation, Isopeptide bond, Methylation, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92804
MaxQBiQ92804
PaxDbiQ92804
PeptideAtlasiQ92804
PRIDEiQ92804

PTM databases

iPTMnetiQ92804
PhosphoSitePlusiQ92804
SwissPalmiQ92804

Miscellaneous databases

PMAP-CutDBiQ92804

Expressioni

Tissue specificityi

Ubiquitous. Observed in all fetal and adult tissues.

Gene expression databases

BgeeiENSG00000270647
CleanExiHS_TAF15
ExpressionAtlasiQ92804 baseline and differential
GenevisibleiQ92804 HS

Organism-specific databases

HPAiHPA052059
HPA063647

Interactioni

Subunit structurei

Belongs to the RNA polymerase II (Pol II) transcriptional multiprotein complex, together with the TATA-binding protein (TBP) and other TBP-associated factors (TAF(II)s). Binds SF1.

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi113807, 69 interactors
CORUMiQ92804
DIPiDIP-52760N
IntActiQ92804, 35 interactors
MINTiQ92804
STRINGi9606.ENSP00000466950

Structurei

Secondary structure

1592
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi236 – 240Combined sources5
Helixi250 – 255Combined sources6
Turni264 – 266Combined sources3
Beta strandi272 – 274Combined sources3
Turni277 – 279Combined sources3
Beta strandi285 – 288Combined sources4
Helixi293 – 301Combined sources9
Beta strandi304 – 308Combined sources5
Beta strandi314 – 316Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2MMYNMR-A231-323[»]
ProteinModelPortaliQ92804
SMRiQ92804
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini234 – 320RRMPROSITE-ProRule annotationAdd BLAST87
Repeati407 – 41317
Repeati414 – 42027
Repeati421 – 42939
Repeati430 – 439410
Repeati440 – 44859
Repeati449 – 45769
Repeati458 – 46578
Repeati466 – 47388
Repeati474 – 48198
Repeati482 – 488107
Repeati489 – 496118
Repeati497 – 503127
Repeati504 – 510137
Repeati511 – 517147
Repeati518 – 524157
Repeati525 – 533169
Repeati534 – 5431710
Repeati544 – 551188
Repeati552 – 560199
Repeati561 – 568208
Repeati569 – 575217

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni407 – 57521 X approximate tandem repeats of D-R-[S,G](0,3)-G-G-Y-G-GAdd BLAST169

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi1 – 208Gln/Gly/Ser/Tyr-richAdd BLAST208
Compositional biasi320 – 590Arg/Gly-richAdd BLAST271

Sequence similaritiesi

Belongs to the RRM TET family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri354 – 385RanBP2-typePROSITE-ProRule annotationAdd BLAST32

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiENOG410IP57 Eukaryota
ENOG4111P4G LUCA
GeneTreeiENSGT00530000063105
HOGENOMiHOG000038010
HOVERGENiHBG005755
InParanoidiQ92804
KOiK14651
OMAiKNSYGDD
OrthoDBiEOG091G0U8W
PhylomeDBiQ92804

Family and domain databases

Gene3Di3.30.70.330, 1 hit
InterProiView protein in InterPro
IPR012677 Nucleotide-bd_a/b_plait_sf
IPR035979 RBD_domain_sf
IPR000504 RRM_dom
IPR034875 TAF15
IPR034870 TET_fam
IPR001876 Znf_RanBP2
IPR036443 Znf_RanBP2_sf
PANTHERiPTHR23238 PTHR23238, 3 hits
PTHR23238:SF25 PTHR23238:SF25, 3 hits
PfamiView protein in Pfam
PF00076 RRM_1, 1 hit
PF00641 zf-RanBP, 1 hit
SMARTiView protein in SMART
SM00360 RRM, 1 hit
SM00547 ZnF_RBZ, 1 hit
SUPFAMiSSF54928 SSF54928, 1 hit
SSF90209 SSF90209, 1 hit
PROSITEiView protein in PROSITE
PS50102 RRM, 1 hit
PS01358 ZF_RANBP2_1, 1 hit
PS50199 ZF_RANBP2_2, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Long (identifier: Q92804-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSDSGSYGQS GGEQQSYSTY GNPGSQGYGQ ASQSYSGYGQ TTDSSYGQNY
60 70 80 90 100
SGYSSYGQSQ SGYSQSYGGY ENQKQSSYSQ QPYNNQGQQQ NMESSGSQGG
110 120 130 140 150
RAPSYDQPDY GQQDSYDQQS GYDQHQGSYD EQSNYDQQHD SYSQNQQSYH
160 170 180 190 200
SQRENYSHHT QDDRRDVSRY GEDNRGYGGS QGGGRGRGGY DKDGRGPMTG
210 220 230 240 250
SSGGDRGGFK NFGGHRDYGP RTDADSESDN SDNNTIFVQG LGEGVSTDQV
260 270 280 290 300
GEFFKQIGII KTNKKTGKPM INLYTDKDTG KPKGEATVSF DDPPSAKAAI
310 320 330 340 350
DWFDGKEFHG NIIKVSFATR RPEFMRGGGS GGGRRGRGGY RGRGGFQGRG
360 370 380 390 400
GDPKSGDWVC PNPSCGNMNF ARRNSCNQCN EPRPEDSRPS GGDFRGRGYG
410 420 430 440 450
GERGYRGRGG RGGDRGGYGG DRSGGGYGGD RSSGGGYSGD RSGGGYGGDR
460 470 480 490 500
SGGGYGGDRG GGYGGDRGGG YGGDRGGGYG GDRGGYGGDR GGGYGGDRGG
510 520 530 540 550
YGGDRGGYGG DRGGYGGDRG GYGGDRSRGG YGGDRGGGSG YGGDRSGGYG
560 570 580 590
GDRSGGGYGG DRGGGYGGDR GGYGGKMGGR NDYRNDQRNR PY
Length:592
Mass (Da):61,830
Last modified:February 1, 1997 - v1
Checksum:i73D37C171E1E2BCA
GO
Isoform Short (identifier: Q92804-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     60-62: Missing.

Show »
Length:589
Mass (Da):61,558
Checksum:i5D24CA4BF574824A
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_00580660 – 62Missing in isoform Short. 3 Publications3

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U51334 mRNA Translation: AAC50932.1
X98893 mRNA Translation: CAA67398.1
AB010067 Genomic DNA Translation: BAA33811.1
AB010067 Genomic DNA Translation: BAA33812.1
AY197697 Genomic DNA Translation: AAO13485.1
AK313223 mRNA Translation: BAG36034.1
AK314194 mRNA Translation: BAG36873.1
AC015849 Genomic DNA No translation available.
CH471147 Genomic DNA Translation: EAW80124.1
CH471147 Genomic DNA Translation: EAW80125.1
BC046099 mRNA Translation: AAH46099.2
CCDSiCCDS32623.1 [Q92804-1]
CCDS59279.1 [Q92804-2]
PIRiS71954
RefSeqiNP_003478.1, NM_003487.3 [Q92804-2]
NP_631961.1, NM_139215.2 [Q92804-1]
UniGeneiHs.402752

Genome annotation databases

EnsembliENST00000604841; ENSP00000474609; ENSG00000270647 [Q92804-2]
ENST00000605844; ENSP00000474096; ENSG00000270647 [Q92804-1]
ENST00000617382; ENSP00000480040; ENSG00000276833 [Q92804-1]
ENST00000631482; ENSP00000488684; ENSG00000276833 [Q92804-2]
GeneIDi8148
KEGGihsa:8148
UCSCiuc002hkc.5 human [Q92804-1]

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement

Similar proteinsi

Entry informationi

Entry nameiRBP56_HUMAN
AccessioniPrimary (citable) accession number: Q92804
Secondary accession number(s): B2R837, Q86X94, Q92751
Entry historyiIntegrated into UniProtKB/Swiss-Prot: December 1, 2000
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 189 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

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