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Protein

NEDD4-binding protein 2-like 2

Gene

N4BP2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of hematopoietic stem cell differentiation Source: UniProtKB
  • negative regulation of transcription from RNA polymerase II promoter Source: UniProtKB
  • positive regulation of hematopoietic stem cell proliferation Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139617-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 2-like 2
Alternative name(s):
Phosphonoformate immuno-associated protein 5
Gene namesi
Name:N4BP2L2
Synonyms:CG005, PFAAP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

HGNCiHGNC:26916. N4BP2L2.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • nucleus Source: UniProtKB
  • transcriptional repressor complex Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

DisGeNETi10443.
OpenTargetsiENSG00000244754.
PharmGKBiPA162396632.

Polymorphism and mutation databases

BioMutaiN4BP2L2.
DMDMi74751659.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990261 – 583NEDD4-binding protein 2-like 2Add BLAST583

Proteomic databases

MaxQBiQ92802.
PaxDbiQ92802.
PeptideAtlasiQ92802.
PRIDEiQ92802.

PTM databases

iPTMnetiQ92802.
PhosphoSitePlusiQ92802.

Expressioni

Gene expression databases

BgeeiENSG00000244754.
CleanExiHS_N4BP2L2.
ExpressionAtlasiQ92802. baseline and differential.
GenevisibleiQ92802. HS.

Organism-specific databases

HPAiHPA039338.
HPA039434.
HPA059327.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
HOXA1P496393EBI-2514973,EBI-740785
Hoxa1P090223EBI-2514973,EBI-3957603From a different organism.
LMO2P257913EBI-2514973,EBI-739696
NAA38Q9BRA03EBI-2514973,EBI-9106509
PPIHO434475EBI-2514973,EBI-1055615

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115708. 29 interactors.
IntActiQ92802. 25 interactors.
MINTiMINT-4720784.
STRINGi9606.ENSP00000382328.

Structurei

3D structure databases

ProteinModelPortaliQ92802.
SMRiQ92802.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili162 – 197Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi558 – 561Poly-Pro4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2401. Eukaryota.
ENOG41101K4. LUCA.
GeneTreeiENSGT00510000047015.
HOGENOMiHOG000113715.
HOVERGENiHBG059710.
InParanoidiQ92802.
OMAiIKMGTAK.
OrthoDBiEOG091G00G9.
PhylomeDBiQ92802.
TreeFamiTF336975.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026568. NEDD4-bind_pro_2-like_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13308:SF26. PTHR13308:SF26. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92802-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYGEIEGKF LGPREEVTSE PRCKKLKSTT ESYVFHNHSN ADFHRIQEKT
60 70 80 90 100
GNDWVPVTII DVRGHSYLQE NKIKTTDLHR PLHDEMPGNR PDVIESIDSQ
110 120 130 140 150
VLQEARPPLV SADDEIYSTS KAFIGPIYKP PEKKKRNEGR NEAHVLNGIN
160 170 180 190 200
DRGGQKEKQK FNSEKSEIDN ELFQFYKEIE ELEKEKDGFE NSCKESEPSQ
210 220 230 240 250
EQFVPFYEGH NNGLLKPDEE KKDLSNKAMP SHCDYQQNLG NEPDKYPCNG
260 270 280 290 300
QVIPTFCDTS FTSFRPEWQS VYPFIVPYGP PLPSLNYHLN IQRFSGPPNP
310 320 330 340 350
PSNIFQAQDD SQIQNGYYVN NCHVNWNCMT FDQNNEYTDC SENRSSVHPS
360 370 380 390 400
GNGCSMQDRY VSNGFCEVRE RCWKDHCMDK HNGTDRFVNQ QFQEEKLNKL
410 420 430 440 450
QKLLILLRGL PGSGKTTLSR ILLGQNRDGI VFSTDDYFHH QDGYRYNVNQ
460 470 480 490 500
LGDAHDWNQN RAKQAIDQGR SPVIIDNTNI QAWEMKPYVE VAIGKGYRVE
510 520 530 540 550
FHEPETWWKF DPEELEKRNK HGVSRKKIAQ MLDRYEYQMS ISIVMNSVEP
560 570 580
SHKSTQRPPP PQGRQRWGGS LGSHNRVCVT NNH
Length:583
Mass (Da):67,459
Last modified:February 1, 1997 - v1
Checksum:i318DC4D81CD0FF2A
GO
Isoform 2 (identifier: Q92802-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-583: WGGSLGSHNRVCVTNNH → FDRKLKRWEE...SVEKRQKKIG

Note: No experimental confirmation available.
Show »
Length:655
Mass (Da):76,082
Checksum:i6CD19BF77B1925BC
GO
Isoform 3 (identifier: Q92802-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-32: GKFLGPREEVTSEPRCKKLKSTTES → EFCLVRIVMALCSALMTIFTIKMGT
     33-461: Missing.
     566-583: RWGGSLGSHNRVCVTNNH → RERVLKKTGH...SVEKRQKKIG

Show »
Length:752
Mass (Da):87,169
Checksum:iAA8CC83570FF4F1A
GO

Sequence cautioni

The sequence AAI31632 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BP361938 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034765272Y → H.Corresponds to variant rs34062461dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413378 – 32GKFLG…STTES → EFCLVRIVMALCSALMTIFT IKMGT in isoform 3. CuratedAdd BLAST25
Alternative sequenceiVSP_04133833 – 461Missing in isoform 3. CuratedAdd BLAST429
Alternative sequenceiVSP_041339566 – 583RWGGS…VTNNH → RERVLKKTGHRLSKTKQKRN RKRNKKQNSQNRIMEENSLE FLSDLTPGDQDPSQSEEEDI EKTRRESEYPFIDGLQNEVG DFVTGYKEKRWKNKDPKDSF QNVMSIVELDNTPKNYLSKE GDNLFVSLLLRPNEISVTCP ILTQNLSCVTTDDCSGMKVE KHIRNRHTIALDTQDLSAET SCLFMKKREIVDKNLSHEPI LCHQHGIRMSDKVLREEQVY TTKINHWAFFTTNLSDEDLQ LGSDRQPYFGSWPAGPHKFI CEQRPKKDRACKLAGPDSRG QWIQMIFTSVAASEPGNNPE ILTDKLLIGNEDFSPPPETM DSFIETNLFRSCLPQPDIPK NALESTKNKKRRKKRIFNLV PNFDLLGQSRIGVKEREKCD LLTKNHGLKITLGEEKDRIS ERNSEEENKQKLMTFDHHPL WFYLDIIKATPLNIDGQRYS HCLSFNRLRCSASLYKNYIP SFVLHNLSSIWKPSFTNKKL FLTFESQTRVGNKLNDAGFI SPEILHSHPDTSCSLGVTSD FHFLNERFDRKLKRWEEPKE LPAEDSQDLTSTDYRSLELP LSQGFAFQLVKLFGSPGVPM ESLLPDDYVVPLDWKTLKMI YLQWKMSVEKRQKKIG in isoform 3. CuratedAdd BLAST18
Alternative sequenceiVSP_027518567 – 583WGGSL…VTNNH → FDRKLKRWEEPKELPAEDSQ DLTSTDYRSLELPLSQGFAF QLVKLFGSPGVPMESLLPDD YVVPLDWKTLKMIYLQWKMS VEKRQKKIG in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50532 mRNA. Translation: AAC50875.1.
AF530063 mRNA. Translation: AAQ09947.1.
AL049783 mRNA. Translation: CAB42441.1.
BT007172 mRNA. Translation: AAP35836.1.
AL353665 Genomic DNA. Translation: CAI11042.1.
CH471075 Genomic DNA. Translation: EAX08514.1.
BC010643 mRNA. Translation: AAH10643.1.
BC131631 mRNA. Translation: AAI31632.1. Sequence problems.
BP361938 mRNA. No translation available.
CCDSiCCDS45024.1. [Q92802-3]
CCDS9346.1. [Q92802-1]
RefSeqiNP_055702.1. NM_014887.2. [Q92802-1]
XP_016875836.1. XM_017020347.1. [Q92802-1]
XP_016875837.1. XM_017020348.1. [Q92802-1]
XP_016875838.1. XM_017020349.1. [Q92802-1]
UniGeneiHs.507680.

Genome annotation databases

EnsembliENST00000267068; ENSP00000267068; ENSG00000244754. [Q92802-1]
ENST00000399396; ENSP00000382328; ENSG00000244754. [Q92802-3]
ENST00000446957; ENSP00000394239; ENSG00000244754. [Q92802-2]
GeneIDi10443.
KEGGihsa:10443.
UCSCiuc001uuk.5. human. [Q92802-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50532 mRNA. Translation: AAC50875.1.
AF530063 mRNA. Translation: AAQ09947.1.
AL049783 mRNA. Translation: CAB42441.1.
BT007172 mRNA. Translation: AAP35836.1.
AL353665 Genomic DNA. Translation: CAI11042.1.
CH471075 Genomic DNA. Translation: EAX08514.1.
BC010643 mRNA. Translation: AAH10643.1.
BC131631 mRNA. Translation: AAI31632.1. Sequence problems.
BP361938 mRNA. No translation available.
CCDSiCCDS45024.1. [Q92802-3]
CCDS9346.1. [Q92802-1]
RefSeqiNP_055702.1. NM_014887.2. [Q92802-1]
XP_016875836.1. XM_017020347.1. [Q92802-1]
XP_016875837.1. XM_017020348.1. [Q92802-1]
XP_016875838.1. XM_017020349.1. [Q92802-1]
UniGeneiHs.507680.

3D structure databases

ProteinModelPortaliQ92802.
SMRiQ92802.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115708. 29 interactors.
IntActiQ92802. 25 interactors.
MINTiMINT-4720784.
STRINGi9606.ENSP00000382328.

PTM databases

iPTMnetiQ92802.
PhosphoSitePlusiQ92802.

Polymorphism and mutation databases

BioMutaiN4BP2L2.
DMDMi74751659.

Proteomic databases

MaxQBiQ92802.
PaxDbiQ92802.
PeptideAtlasiQ92802.
PRIDEiQ92802.

Protocols and materials databases

DNASUi10443.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000267068; ENSP00000267068; ENSG00000244754. [Q92802-1]
ENST00000399396; ENSP00000382328; ENSG00000244754. [Q92802-3]
ENST00000446957; ENSP00000394239; ENSG00000244754. [Q92802-2]
GeneIDi10443.
KEGGihsa:10443.
UCSCiuc001uuk.5. human. [Q92802-1]

Organism-specific databases

CTDi10443.
DisGeNETi10443.
GeneCardsiN4BP2L2.
HGNCiHGNC:26916. N4BP2L2.
HPAiHPA039338.
HPA039434.
HPA059327.
MIMi615788. gene.
neXtProtiNX_Q92802.
OpenTargetsiENSG00000244754.
PharmGKBiPA162396632.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG2401. Eukaryota.
ENOG41101K4. LUCA.
GeneTreeiENSGT00510000047015.
HOGENOMiHOG000113715.
HOVERGENiHBG059710.
InParanoidiQ92802.
OMAiIKMGTAK.
OrthoDBiEOG091G00G9.
PhylomeDBiQ92802.
TreeFamiTF336975.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000139617-MONOMER.

Miscellaneous databases

ChiTaRSiN4BP2L2. human.
GenomeRNAii10443.
PROiQ92802.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000244754.
CleanExiHS_N4BP2L2.
ExpressionAtlasiQ92802. baseline and differential.
GenevisibleiQ92802. HS.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR026568. NEDD4-bind_pro_2-like_2.
IPR027417. P-loop_NTPase.
[Graphical view]
PANTHERiPTHR13308:SF26. PTHR13308:SF26. 1 hit.
SUPFAMiSSF52540. SSF52540. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiN42L2_HUMAN
AccessioniPrimary (citable) accession number: Q92802
Secondary accession number(s): A3KME8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 134 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 13
    Human chromosome 13: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.