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Protein

NEDD4-binding protein 2-like 2

Gene

N4BP2L2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

GO - Molecular functioni

  • enzyme binding Source: UniProtKB
  • RNA polymerase II transcription corepressor activity Source: UniProtKB

GO - Biological processi

  • negative regulation of hematopoietic stem cell differentiation Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: UniProtKB
  • positive regulation of hematopoietic stem cell proliferation Source: UniProtKB

Names & Taxonomyi

Protein namesi
Recommended name:
NEDD4-binding protein 2-like 2
Alternative name(s):
Phosphonoformate immuno-associated protein 5
Gene namesi
Name:N4BP2L2
Synonyms:CG005, PFAAP5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 13

Organism-specific databases

EuPathDBiHostDB:ENSG00000244754.8
HGNCiHGNC:26916 N4BP2L2
MIMi615788 gene
neXtProtiNX_Q92802

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Pathology & Biotechi

Organism-specific databases

DisGeNETi10443
OpenTargetsiENSG00000244754
PharmGKBiPA162396632

Polymorphism and mutation databases

BioMutaiN4BP2L2
DMDMi74751659

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002990261 – 583NEDD4-binding protein 2-like 2Add BLAST583

Proteomic databases

MaxQBiQ92802
PaxDbiQ92802
PeptideAtlasiQ92802
PRIDEiQ92802

PTM databases

iPTMnetiQ92802
PhosphoSitePlusiQ92802

Expressioni

Gene expression databases

BgeeiENSG00000244754
CleanExiHS_N4BP2L2
ExpressionAtlasiQ92802 baseline and differential
GenevisibleiQ92802 HS

Organism-specific databases

HPAiHPA039338
HPA039434
HPA059327

Interactioni

Binary interactionsi

Show more details

GO - Molecular functioni

  • enzyme binding Source: UniProtKB

Protein-protein interaction databases

BioGridi115708, 37 interactors
IntActiQ92802, 25 interactors
STRINGi9606.ENSP00000382328

Structurei

3D structure databases

ProteinModelPortaliQ92802
SMRiQ92802
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili162 – 197Sequence analysisAdd BLAST36

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi558 – 561Poly-Pro4

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiKOG2401 Eukaryota
ENOG41101K4 LUCA
GeneTreeiENSGT00510000047015
HOGENOMiHOG000113715
HOVERGENiHBG059710
InParanoidiQ92802
OMAiIKMGTAK
OrthoDBiEOG091G00G9
PhylomeDBiQ92802
TreeFamiTF336975

Family and domain databases

InterProiView protein in InterPro
IPR026568 NEDD4-bind_pro_2-like_2
IPR027417 P-loop_NTPase
PANTHERiPTHR13308:SF23 PTHR13308:SF23, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92802-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSYGEIEGKF LGPREEVTSE PRCKKLKSTT ESYVFHNHSN ADFHRIQEKT
60 70 80 90 100
GNDWVPVTII DVRGHSYLQE NKIKTTDLHR PLHDEMPGNR PDVIESIDSQ
110 120 130 140 150
VLQEARPPLV SADDEIYSTS KAFIGPIYKP PEKKKRNEGR NEAHVLNGIN
160 170 180 190 200
DRGGQKEKQK FNSEKSEIDN ELFQFYKEIE ELEKEKDGFE NSCKESEPSQ
210 220 230 240 250
EQFVPFYEGH NNGLLKPDEE KKDLSNKAMP SHCDYQQNLG NEPDKYPCNG
260 270 280 290 300
QVIPTFCDTS FTSFRPEWQS VYPFIVPYGP PLPSLNYHLN IQRFSGPPNP
310 320 330 340 350
PSNIFQAQDD SQIQNGYYVN NCHVNWNCMT FDQNNEYTDC SENRSSVHPS
360 370 380 390 400
GNGCSMQDRY VSNGFCEVRE RCWKDHCMDK HNGTDRFVNQ QFQEEKLNKL
410 420 430 440 450
QKLLILLRGL PGSGKTTLSR ILLGQNRDGI VFSTDDYFHH QDGYRYNVNQ
460 470 480 490 500
LGDAHDWNQN RAKQAIDQGR SPVIIDNTNI QAWEMKPYVE VAIGKGYRVE
510 520 530 540 550
FHEPETWWKF DPEELEKRNK HGVSRKKIAQ MLDRYEYQMS ISIVMNSVEP
560 570 580
SHKSTQRPPP PQGRQRWGGS LGSHNRVCVT NNH
Length:583
Mass (Da):67,459
Last modified:February 1, 1997 - v1
Checksum:i318DC4D81CD0FF2A
GO
Isoform 2 (identifier: Q92802-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     567-583: WGGSLGSHNRVCVTNNH → FDRKLKRWEE...SVEKRQKKIG

Note: No experimental confirmation available.
Show »
Length:655
Mass (Da):76,082
Checksum:i6CD19BF77B1925BC
GO
Isoform 3 (identifier: Q92802-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     8-32: GKFLGPREEVTSEPRCKKLKSTTES → EFCLVRIVMALCSALMTIFTIKMGT
     33-461: Missing.
     566-583: RWGGSLGSHNRVCVTNNH → RERVLKKTGH...SVEKRQKKIG

Show »
Length:752
Mass (Da):87,169
Checksum:iAA8CC83570FF4F1A
GO

Sequence cautioni

The sequence AAI31632 differs from that shown. Contaminating sequence. Sequence of unknown origin in the N-terminal part.Curated
The sequence BP361938 differs from that shown. Reason: Frameshift at several positions.Curated

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_034765272Y → H. Corresponds to variant dbSNP:rs34062461Ensembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0413378 – 32GKFLG…STTES → EFCLVRIVMALCSALMTIFT IKMGT in isoform 3. CuratedAdd BLAST25
Alternative sequenceiVSP_04133833 – 461Missing in isoform 3. CuratedAdd BLAST429
Alternative sequenceiVSP_041339566 – 583RWGGS…VTNNH → RERVLKKTGHRLSKTKQKRN RKRNKKQNSQNRIMEENSLE FLSDLTPGDQDPSQSEEEDI EKTRRESEYPFIDGLQNEVG DFVTGYKEKRWKNKDPKDSF QNVMSIVELDNTPKNYLSKE GDNLFVSLLLRPNEISVTCP ILTQNLSCVTTDDCSGMKVE KHIRNRHTIALDTQDLSAET SCLFMKKREIVDKNLSHEPI LCHQHGIRMSDKVLREEQVY TTKINHWAFFTTNLSDEDLQ LGSDRQPYFGSWPAGPHKFI CEQRPKKDRACKLAGPDSRG QWIQMIFTSVAASEPGNNPE ILTDKLLIGNEDFSPPPETM DSFIETNLFRSCLPQPDIPK NALESTKNKKRRKKRIFNLV PNFDLLGQSRIGVKEREKCD LLTKNHGLKITLGEEKDRIS ERNSEEENKQKLMTFDHHPL WFYLDIIKATPLNIDGQRYS HCLSFNRLRCSASLYKNYIP SFVLHNLSSIWKPSFTNKKL FLTFESQTRVGNKLNDAGFI SPEILHSHPDTSCSLGVTSD FHFLNERFDRKLKRWEEPKE LPAEDSQDLTSTDYRSLELP LSQGFAFQLVKLFGSPGVPM ESLLPDDYVVPLDWKTLKMI YLQWKMSVEKRQKKIG in isoform 3. CuratedAdd BLAST18
Alternative sequenceiVSP_027518567 – 583WGGSL…VTNNH → FDRKLKRWEEPKELPAEDSQ DLTSTDYRSLELPLSQGFAF QLVKLFGSPGVPMESLLPDD YVVPLDWKTLKMIYLQWKMS VEKRQKKIG in isoform 2. 1 PublicationAdd BLAST17

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U50532 mRNA Translation: AAC50875.1
AF530063 mRNA Translation: AAQ09947.1
AL049783 mRNA Translation: CAB42441.1
BT007172 mRNA Translation: AAP35836.1
AL353665 Genomic DNA No translation available.
CH471075 Genomic DNA Translation: EAX08514.1
BC010643 mRNA Translation: AAH10643.1
BC131631 mRNA Translation: AAI31632.1 Sequence problems.
BP361938 mRNA No translation available.
CCDSiCCDS45024.1 [Q92802-3]
CCDS9346.1 [Q92802-1]
RefSeqiNP_055702.1, NM_014887.2 [Q92802-1]
XP_016875836.1, XM_017020347.1 [Q92802-1]
XP_016875837.1, XM_017020348.1 [Q92802-1]
XP_016875838.1, XM_017020349.1 [Q92802-1]
UniGeneiHs.507680

Genome annotation databases

EnsembliENST00000267068; ENSP00000267068; ENSG00000244754 [Q92802-1]
ENST00000399396; ENSP00000382328; ENSG00000244754 [Q92802-3]
ENST00000446957; ENSP00000394239; ENSG00000244754 [Q92802-2]
GeneIDi10443
KEGGihsa:10443
UCSCiuc001uuk.5 human [Q92802-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiN42L2_HUMAN
AccessioniPrimary (citable) accession number: Q92802
Secondary accession number(s): A3KME8
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 11, 2007
Last sequence update: February 1, 1997
Last modified: March 28, 2018
This is version 143 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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