Q92800 (EZH1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Histone-lysine N-methyltransferase EZH1
EC=2.1.1.43

Alternative name(s):
ENX-2
Enhancer of zeste homolog 1

Gene names

Name:	EZH1
Synonyms:	KIAA0388

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	747 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH1-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation. Ref.10
Catalytic activity	S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone]. Ref.10
Subunit structure	Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM). Ref.10
Subcellular location	Nucleus. Note: Colocalizes with trimethylated 'Lys-27' of histone H3. Ref.10
Sequence similarities	Belongs to the histone-lysine methyltransferase family. EZ subfamily. Contains 1 CXC domain. Contains 1 SET domain.
Sequence caution	The sequence BAA20842.2 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Ligand	S-adenosyl-L-methionine
Molecular function	Chromatin regulator Methyltransferase Repressor Transferase
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.1. Source: ProtInc negative regulation of transcription from RNA polymerase II promoter Inferred from electronic annotation. Source: Compara transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	ESC/E(Z) complex Inferred from direct assay PubMed 20075857. Source: UniProtKB
Molecular_function	chromatin binding Traceable author statement Ref.1. Source: ProtInc histone methyltransferase activity (H3-K27 specific) Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Alternative products

This entry describes 5 isoforms produced by alternative splicing. [Align] [Select]

Isoform 1 (identifier: Q92800-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 2 (identifier: Q92800-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MEDYSKM

Note: No experimental confirmation available.

Isoform 3 (identifier: Q92800-3)

The sequence of this isoform differs from the canonical sequence as follows:
     83-122: Missing.

Note: No experimental confirmation available.

Isoform 4 (identifier: Q92800-4)

The sequence of this isoform differs from the canonical sequence as follows:
     1-70: Missing.

Note: No experimental confirmation available.

Isoform 5 (identifier: Q92800-5)

The sequence of this isoform differs from the canonical sequence as follows:
     1-162: MEIPNPPTSK...NYDGKVHGEE → MEEASCPTCSVNEACEWTPFSQK

Note: No experimental confirmation available.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 747	747	Histone-lysine N-methyltransferase EZH1		PRO_0000213990
Regions
	Domain	504 – 606	103	CXC
	Domain	612 – 732	121	SET
	Motif	491 – 496	6	Nuclear localization signal Potential
	Compositional bias	524 – 606	83	Cys-rich
Natural variations
	Alternative sequence	1 – 162	162	MEIPN…VHGEE → MEEASCPTCSVNEACEWTPF SQK in isoform 5.		VSP_036384
	Alternative sequence	1 – 70	70	Missing in isoform 4.		VSP_036385
	Alternative sequence	1	1	M → MEDYSKM in isoform 2.		VSP_036386
	Alternative sequence	83 – 122	40	Missing in isoform 3.		VSP_036387
Experimental info
	Mutagenesis	690	1	H → A: Loss of methyltransferase activity. Ref.10
	Sequence conflict	24	1	M → I in BAG58503. Ref.5
	Sequence conflict	353	1	P → S in BAA25019. Ref.2
	Sequence conflict	389	1	D → Y in BAG65579. Ref.5
	Sequence conflict	488	1	N → Y in AAC50778. Ref.1
	Sequence conflict	532 – 535	4	DSTC → EAL in BAA25019. Ref.2
	Sequence conflict	591 – 602	12	ASEHW…KVVSC → PQSTGTARWFPV in BAA25019. Ref.2
	Sequence conflict	631	1	E → K in BAG61734. Ref.5
	Sequence conflict	697	1	Y → C in BAG58659. Ref.5
	Sequence conflict	700 – 747	48	VVMVN…ETDVL → GESQ in BAA25019. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform 1 [UniParc]. Last modified July 15, 1998. Version 2. Checksum: 7CFC52269CDA011B	FASTA	747	85,271
	10 20 30 40 50 60 MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 70 80 90 100 110 120 KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN 130 140 150 160 170 180 FMVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV 190 200 210 220 230 240 DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI 250 260 270 280 290 300 ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 310 320 330 340 350 360 RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR 370 380 390 400 410 420 RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP 430 440 450 460 470 480 QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK 490 500 510 520 530 540 LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT 550 560 570 580 590 600 QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 610 620 630 640 650 660 SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD 670 680 690 700 710 720 KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG 730 740 EELFFDYRYS QADALKYVGI ERETDVL
	Isoform 2 [UniParc]. Checksum: DC9F0DF9E60EFA55	FASTA	753	86,025
	10 20 30 40 50 60 MEDYSKMEIP NPPTSKCITY WKRKVKSEYM RLRQLKRLQA NMGAKALYVA NFAKVQEKTQ 70 80 90 100 110 120 ILNEEWKKLR VQPVQSMKPV SGHPFLKKCT IESIFPGFAS QHMLMRSLNT VALVPIMYSW 130 140 150 160 170 180 SPLQQNFMVE DETVLCNIPY MGDEVKEEDE TFIEELINNY DGKVHGEEEM IPGSVLISDA 190 200 210 220 230 240 VFLELVDALN QYSDEEEEGH NDTSDGKQDD SKEDLPVTRK RKRHAIEGNK KSSKKQFPND 250 260 270 280 290 300 MIFSAIASMF PENGVPDDMK ERYRELTEMS DPNALPPQCT PNIDGPNAKS VQREQSLHSF 310 320 330 340 350 360 HTLFCRRCFK YDCFLHPFHA TPNVYKRKNK EIKIEPEPCG TDCFLLLEGA KEYAMLHNPR 370 380 390 400 410 420 SKCSGRRRRR HHIVSASCSN ASASAVAETK EGDSDRDTGN DWASSSSEAN SRCQTPTKQK 430 440 450 460 470 480 ASPAPPQLCV VEAPSEPVEW TGAEESLFRV FHGTYFNNFC SIARLLGTKT CKQVFQFAVK 490 500 510 520 530 540 ESLILKLPTD ELMNPSQKKK RKHRLWAAHC RKIQLKKDNS STQVYNYQPC DHPDRPCDST 550 560 570 580 590 600 CPCIMTQNFC EKFCQCNPDC QNRFPGCRCK TQCNTKQCPC YLAVRECDPD LCLTCGASEH 610 620 630 640 650 660 WDCKVVSCKN CSIQRGLKKH LLLAPSDVAG WGTFIKESVQ KNEFISEYCG ELISQDEADR 670 680 690 700 710 720 RGKVYDKYMS SFLFNLNNDF VVDATRKGNK IRFANHSVNP NCYAKVVMVN GDHRIGIFAK 730 740 750 RAIQAGEELF FDYRYSQADA LKYVGIERET DVL
	Isoform 3 [UniParc]. Checksum: 23A8A70A4B0A426F	FASTA	707	80,699
	10 20 30 40 50 60 MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ EKTQILNEEW 70 80 90 100 110 120 KKLRVQPVQS MKPVSGHPFL KKVEDETVLC NIPYMGDEVK EEDETFIEEL INNYDGKVHG 130 140 150 160 170 180 EEEMIPGSVL ISDAVFLELV DALNQYSDEE EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI 190 200 210 220 230 240 EGNKKSSKKQ FPNDMIFSAI ASMFPENGVP DDMKERYREL TEMSDPNALP PQCTPNIDGP 250 260 270 280 290 300 NAKSVQREQS LHSFHTLFCR RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL 310 320 330 340 350 360 LEGAKEYAML HNPRSKCSGR RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS 370 380 390 400 410 420 SEANSRCQTP TKQKASPAPP QLCVVEAPSE PVEWTGAEES LFRVFHGTYF NNFCSIARLL 430 440 450 460 470 480 GTKTCKQVFQ FAVKESLILK LPTDELMNPS QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN 490 500 510 520 530 540 YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE 550 560 570 580 590 600 CDPDLCLTCG ASEHWDCKVV SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS 610 620 630 640 650 660 EYCGELISQD EADRRGKVYD KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV 670 680 690 700 VMVNGDHRIG IFAKRAIQAG EELFFDYRYS QADALKYVGI ERETDVL
	Isoform 4 [UniParc]. Checksum: 319C9A015FC818F1	FASTA	677	76,952
	10 20 30 40 50 60 MKPVSGHPFL KKCTIESIFP GFASQHMLMR SLNTVALVPI MYSWSPLQQN FMVEDETVLC 70 80 90 100 110 120 NIPYMGDEVK EEDETFIEEL INNYDGKVHG EEEMIPGSVL ISDAVFLELV DALNQYSDEE 130 140 150 160 170 180 EEGHNDTSDG KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI ASMFPENGVP 190 200 210 220 230 240 DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR RCFKYDCFLH 250 260 270 280 290 300 PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML HNPRSKCSGR RRRRHHIVSA 310 320 330 340 350 360 SCSNASASAV AETKEGDSDR DTGNDWASSS SEANSRCQTP TKQKASPAPP QLCVVEAPSE 370 380 390 400 410 420 PVEWTGAEES LFRVFHGTYF NNFCSIARLL GTKTCKQVFQ FAVKESLILK LPTDELMNPS 430 440 450 460 470 480 QKKKRKHRLW AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC 490 500 510 520 530 540 NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV SCKNCSIQRG 550 560 570 580 590 600 LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD EADRRGKVYD KYMSSFLFNL 610 620 630 640 650 660 NNDFVVDATR KGNKIRFANH SVNPNCYAKV VMVNGDHRIG IFAKRAIQAG EELFFDYRYS 670 QADALKYVGI ERETDVL
	Isoform 5 [UniParc]. Checksum: E9C73223693D99DC	FASTA	608	68,961
	10 20 30 40 50 60 MEEASCPTCS VNEACEWTPF SQKEMIPGSV LISDAVFLEL VDALNQYSDE EEEGHNDTSD 70 80 90 100 110 120 GKQDDSKEDL PVTRKRKRHA IEGNKKSSKK QFPNDMIFSA IASMFPENGV PDDMKERYRE 130 140 150 160 170 180 LTEMSDPNAL PPQCTPNIDG PNAKSVQREQ SLHSFHTLFC RRCFKYDCFL HPFHATPNVY 190 200 210 220 230 240 KRKNKEIKIE PEPCGTDCFL LLEGAKEYAM LHNPRSKCSG RRRRRHHIVS ASCSNASASA 250 260 270 280 290 300 VAETKEGDSD RDTGNDWASS SSEANSRCQT PTKQKASPAP PQLCVVEAPS EPVEWTGAEE 310 320 330 340 350 360 SLFRVFHGTY FNNFCSIARL LGTKTCKQVF QFAVKESLIL KLPTDELMNP SQKKKRKHRL 370 380 390 400 410 420 WAAHCRKIQL KKDNSSTQVY NYQPCDHPDR PCDSTCPCIM TQNFCEKFCQ CNPDCQNRFP 430 440 450 460 470 480 GCRCKTQCNT KQCPCYLAVR ECDPDLCLTC GASEHWDCKV VSCKNCSIQR GLKKHLLLAP 490 500 510 520 530 540 SDVAGWGTFI KESVQKNEFI SEYCGELISQ DEADRRGKVY DKYMSSFLFN LNNDFVVDAT 550 560 570 580 590 600 RKGNKIRFAN HSVNPNCYAK VVMVNGDHRI GIFAKRAIQA GEELFFDYRY SQADALKYVG IERETDVL

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Characterization of EZH1, a human homolog of Drosophila Enhancer of zeste near BRCA1." Abel K.J., Brody L.C., Valdes J.M., Erdos M.R., McKinley D.R., Castilla L.H., Merajver S.D., Couch F.J., Friedman L.S., Ostermeyer E.A., Lynch E.D., King M.-C., Welcsh P.L., Osborne-Lawrence S., Spillman M., Bowcock A.M., Collins F.S., Weber B.L. Genomics 37:161-171(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[2]	"Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2." Ogawa M., Hiraoka Y., Taniguchi K., Aiso S. Biochim. Biophys. Acta 1395:151-158(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
[3]	"Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro." Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O. DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Brain.
[4]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
[5]	"Complete sequencing and characterization of 21,243 full-length human cDNAs." Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S. Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5). Tissue: Brain, Hippocampus and Uterus.
[6]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[7]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[8]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1). Tissue: Uterus.
[9]	"Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21." Rommens J.M., Durocher F., McArthur J., Tonin P., Leblanc J.-F., Allen T., Samson C., Ferri L., Narod S., Morgan K., Simard J. Genomics 28:530-542(1995) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-538.
[10]	"Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms." Margueron R., Li G., Sarma K., Blais A., Zavadil J., Woodcock C.L., Dynlacht B.D., Reinberg D. Mol. Cell 32:503-518(2008) [PubMed] [Europe PMC] [Abstract] Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX, MUTAGENESIS OF HIS-690.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U50315 mRNA. Translation: AAC50778.1. AB004818 mRNA. Translation: BAA25019.1. AB002386 mRNA. Translation: BAA20842.2. Different initiation. BT009782 mRNA. Translation: AAP88784.1. AK304835 mRNA. Translation: BAG65579.1. AK295626 mRNA. Translation: BAG58503.1. AK295853 mRNA. Translation: BAG58659.1. AK299887 mRNA. Translation: BAG61734.1. AC100793 Genomic DNA. No translation available. CH471152 Genomic DNA. Translation: EAW60870.1. BC015882 mRNA. Translation: AAH15882.1. L38934 mRNA. Translation: AAB59574.1.
IPI	IPI00023672. IPI00921136. IPI00921257. IPI00921284. IPI00921311.
RefSeq	NP_001982.2. NM_001991.3.
UniGene	Hs.194669.
3D structure databases
ProteinModelPortal	Q92800.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-58580N.
PTM databases
PhosphoSite	Q92800.
Polymorphism databases
DMDM	3334182.
Proteomic databases
PaxDb	Q92800.
PRIDE	Q92800.
Protocols and materials databases
DNASU	2145.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000428826; ENSP00000404658; ENSG00000108799. ENST00000435174; ENSP00000404071; ENSG00000108799. ENST00000585893; ENSP00000467871; ENSG00000108799. ENST00000590078; ENSP00000465220; ENSG00000108799. ENST00000592743; ENSP00000466924; ENSG00000108799.
GeneID	2145.
KEGG	hsa:2145.
UCSC	uc002iaz.3. human. uc010cyo.1. human. uc010wgu.2. human. uc010wgv.2. human.
Organism-specific databases
CTD	2145.
GeneCards	GC17M040852.
HGNC	HGNC:3526. EZH1.
HPA	HPA005478.
MIM	601674. gene.
neXtProt	NX_Q92800.
PharmGKB	PA27938.
HUGE	Search...
GenAtlas	Search...
Phylogenomic databases
eggNOG	COG2940.
HOVERGEN	HBG002453.
InParanoid	Q92800.
KO	K11430.
OrthoDB	EOG4CJVGK.
Gene expression databases
Bgee	Q92800.
CleanEx	HS_EZH1.
Genevestigator	Q92800.
GermOnline	ENSG00000108799. Homo sapiens.
Family and domain databases
InterPro	IPR026489. CXC_dom. IPR021654. EZH2_WD-Binding. IPR001005. SANT/Myb. IPR001214. SET_dom. [Graphical view]
Pfam	PF11616. EZH2_WD-Binding. 1 hit. PF00856. SET. 1 hit. [Graphical view]
SMART	SM00717. SANT. 2 hits. SM00317. SET. 1 hit. [Graphical view]
PROSITE	PS51633. CXC. 1 hit. PS50280. SET. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	EZH1. human.
GenomeRNAi	2145.
NextBio	8671.
SOURCE	Search...

Entry information

Entry name

EZH1_HUMAN

Accession

Primary (citable) accession number: Q92800
Secondary accession number(s): A6NCH6 , B4DIJ1, B4DIZ7, B4DSS2, B4E3R7, O43287, Q14459, Q53XP3

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	July 15, 1998
Last modified:	May 1, 2013
This is version 122 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.