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Q92800

- EZH1_HUMAN

UniProt

Q92800 - EZH1_HUMAN

Protein

Histone-lysine N-methyltransferase EZH1

Gene

EZH1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 134 (01 Oct 2014)
      Sequence version 2 (15 Jul 1998)
      Previous versions | rss
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    Functioni

    Polycomb group (PcG) protein. Catalytic subunit of the PRC2/EED-EZH1 complex, which methylates 'Lys-27' of histone H3, leading to transcriptional repression of the affected target gene. Able to mono-, di- and trimethylate 'Lys-27' of histone H3 to form H3K27me1, H3K27me2 and H3K27me3, respectively. Required for embryonic stem cell derivation and self-renewal, suggesting that it is involved in safeguarding embryonic stem cell identity. Compared to EZH2-containing complexes, it is less abundant in embryonic stem cells, has weak methyltransferase activity and plays a less critical role in forming H3K27me3, which is required for embryonic stem cell identity and proper differentiation.1 Publication

    Catalytic activityi

    S-adenosyl-L-methionine + L-lysine-[histone] = S-adenosyl-L-homocysteine + N(6)-methyl-L-lysine-[histone].1 Publication

    GO - Molecular functioni

    1. chromatin binding Source: ProtInc
    2. histone methyltransferase activity (H3-K27 specific) Source: Ensembl

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc
    2. negative regulation of transcription from RNA polymerase II promoter Source: Ensembl
    3. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Chromatin regulator, Methyltransferase, Repressor, Transferase

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    S-adenosyl-L-methionine

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Histone-lysine N-methyltransferase EZH1 (EC:2.1.1.43)
    Alternative name(s):
    ENX-2
    Enhancer of zeste homolog 1
    Gene namesi
    Name:EZH1
    Synonyms:KIAA0388
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:3526. EZH1.

    Subcellular locationi

    Nucleus 1 Publication
    Note: Colocalizes with trimethylated 'Lys-27' of histone H3.

    GO - Cellular componenti

    1. ESC/E(Z) complex Source: UniProtKB
    2. nucleus Source: HPA

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi690 – 6901H → A: Loss of methyltransferase activity. 1 Publication

    Organism-specific databases

    PharmGKBiPA27938.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 747747Histone-lysine N-methyltransferase EZH1PRO_0000213990Add
    BLAST

    Proteomic databases

    MaxQBiQ92800.
    PaxDbiQ92800.
    PRIDEiQ92800.

    PTM databases

    PhosphoSiteiQ92800.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92800.
    BgeeiQ92800.
    CleanExiHS_EZH1.
    GenevestigatoriQ92800.

    Organism-specific databases

    HPAiHPA005478.

    Interactioni

    Subunit structurei

    Component of the PRC2/EED-EZH1 complex, which includes EED, EZH1, SUZ12, RBBP4 and AEBP2. The PRC2/EED-EZH1 is less abundant than the PRC2/EED-EZH2 complex, has weak methyltransferase activity and compacts chromatin in the absence of the methyltransferase cofactor S-adenosyl-L-methionine (SAM).1 Publication

    Protein-protein interaction databases

    BioGridi108445. 10 interactions.
    DIPiDIP-58580N.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92800.
    SMRiQ92800. Positions 521-730.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini504 – 606103CXCPROSITE-ProRule annotationAdd
    BLAST
    Domaini613 – 728116SETPROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi491 – 4966Nuclear localization signalSequence Analysis

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi524 – 60683Cys-richAdd
    BLAST

    Sequence similaritiesi

    Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. EZ subfamily.PROSITE-ProRule annotation
    Contains 1 CXC domain.PROSITE-ProRule annotation
    Contains 1 SET domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG2940.
    HOVERGENiHBG002453.
    InParanoidiQ92800.
    KOiK17451.
    OMAiSTQVYNY.
    OrthoDBiEOG7VB2DR.
    PhylomeDBiQ92800.
    TreeFamiTF314509.

    Family and domain databases

    InterProiIPR026489. CXC_dom.
    IPR021654. EZH2_WD-Binding.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view]
    PfamiPF11616. EZH2_WD-Binding. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view]
    SMARTiSM00717. SANT. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view]
    PROSITEiPS51633. CXC. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view]

    Sequences (5)i

    Sequence statusi: Complete.

    This entry describes 5 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92800-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MEIPNPPTSK CITYWKRKVK SEYMRLRQLK RLQANMGAKA LYVANFAKVQ    50
    EKTQILNEEW KKLRVQPVQS MKPVSGHPFL KKCTIESIFP GFASQHMLMR 100
    SLNTVALVPI MYSWSPLQQN FMVEDETVLC NIPYMGDEVK EEDETFIEEL 150
    INNYDGKVHG EEEMIPGSVL ISDAVFLELV DALNQYSDEE EEGHNDTSDG 200
    KQDDSKEDLP VTRKRKRHAI EGNKKSSKKQ FPNDMIFSAI ASMFPENGVP 250
    DDMKERYREL TEMSDPNALP PQCTPNIDGP NAKSVQREQS LHSFHTLFCR 300
    RCFKYDCFLH PFHATPNVYK RKNKEIKIEP EPCGTDCFLL LEGAKEYAML 350
    HNPRSKCSGR RRRRHHIVSA SCSNASASAV AETKEGDSDR DTGNDWASSS 400
    SEANSRCQTP TKQKASPAPP QLCVVEAPSE PVEWTGAEES LFRVFHGTYF 450
    NNFCSIARLL GTKTCKQVFQ FAVKESLILK LPTDELMNPS QKKKRKHRLW 500
    AAHCRKIQLK KDNSSTQVYN YQPCDHPDRP CDSTCPCIMT QNFCEKFCQC 550
    NPDCQNRFPG CRCKTQCNTK QCPCYLAVRE CDPDLCLTCG ASEHWDCKVV 600
    SCKNCSIQRG LKKHLLLAPS DVAGWGTFIK ESVQKNEFIS EYCGELISQD 650
    EADRRGKVYD KYMSSFLFNL NNDFVVDATR KGNKIRFANH SVNPNCYAKV 700
    VMVNGDHRIG IFAKRAIQAG EELFFDYRYS QADALKYVGI ERETDVL 747
    Length:747
    Mass (Da):85,271
    Last modified:July 15, 1998 - v2
    Checksum:i7CFC52269CDA011B
    GO
    Isoform 2 (identifier: Q92800-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-1: M → MEDYSKM

    Note: No experimental confirmation available.

    Show »
    Length:753
    Mass (Da):86,025
    Checksum:iDC9F0DF9E60EFA55
    GO
    Isoform 3 (identifier: Q92800-3) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         83-122: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:707
    Mass (Da):80,699
    Checksum:i23A8A70A4B0A426F
    GO
    Isoform 4 (identifier: Q92800-4) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-70: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:677
    Mass (Da):76,952
    Checksum:i319C9A015FC818F1
    GO
    Isoform 5 (identifier: Q92800-5) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-162: MEIPNPPTSK...NYDGKVHGEE → MEEASCPTCSVNEACEWTPFSQK

    Note: No experimental confirmation available.

    Show »
    Length:608
    Mass (Da):68,961
    Checksum:iE9C73223693D99DC
    GO

    Sequence cautioni

    The sequence BAA20842.2 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti24 – 241M → I in BAG58503. (PubMed:14702039)Curated
    Sequence conflicti353 – 3531P → S in BAA25019. (PubMed:9473645)Curated
    Sequence conflicti389 – 3891D → Y in BAG65579. (PubMed:14702039)Curated
    Sequence conflicti488 – 4881N → Y in AAC50778. (PubMed:8921387)Curated
    Sequence conflicti532 – 5354DSTC → EAL in BAA25019. (PubMed:9473645)Curated
    Sequence conflicti591 – 60212ASEHW…KVVSC → PQSTGTARWFPV in BAA25019. (PubMed:9473645)CuratedAdd
    BLAST
    Sequence conflicti631 – 6311E → K in BAG61734. (PubMed:14702039)Curated
    Sequence conflicti697 – 6971Y → C in BAG58659. (PubMed:14702039)Curated
    Sequence conflicti700 – 74748VVMVN…ETDVL → GESQ in BAA25019. (PubMed:9473645)CuratedAdd
    BLAST

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 162162MEIPN…VHGEE → MEEASCPTCSVNEACEWTPF SQK in isoform 5. 1 PublicationVSP_036384Add
    BLAST
    Alternative sequencei1 – 7070Missing in isoform 4. 1 PublicationVSP_036385Add
    BLAST
    Alternative sequencei1 – 11M → MEDYSKM in isoform 2. 1 PublicationVSP_036386
    Alternative sequencei83 – 12240Missing in isoform 3. 1 PublicationVSP_036387Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50315 mRNA. Translation: AAC50778.1.
    AB004818 mRNA. Translation: BAA25019.1.
    AB002386 mRNA. Translation: BAA20842.2. Different initiation.
    BT009782 mRNA. Translation: AAP88784.1.
    AK304835 mRNA. Translation: BAG65579.1.
    AK295626 mRNA. Translation: BAG58503.1.
    AK295853 mRNA. Translation: BAG58659.1.
    AK299887 mRNA. Translation: BAG61734.1.
    AC100793 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60870.1.
    BC015882 mRNA. Translation: AAH15882.1.
    L38934 mRNA. Translation: AAB59574.1.
    CCDSiCCDS32659.1. [Q92800-1]
    RefSeqiNP_001982.2. NM_001991.3. [Q92800-1]
    XP_005257201.1. XM_005257144.1. [Q92800-2]
    XP_005257203.1. XM_005257146.1. [Q92800-3]
    UniGeneiHs.194669.

    Genome annotation databases

    EnsembliENST00000428826; ENSP00000404658; ENSG00000108799. [Q92800-1]
    ENST00000585893; ENSP00000467871; ENSG00000108799. [Q92800-3]
    ENST00000590078; ENSP00000465220; ENSG00000108799. [Q92800-4]
    ENST00000592743; ENSP00000466924; ENSG00000108799. [Q92800-1]
    GeneIDi2145.
    KEGGihsa:2145.
    UCSCiuc002iaz.3. human. [Q92800-1]
    uc010cyo.1. human. [Q92800-5]
    uc010wgu.2. human. [Q92800-2]
    uc010wgv.2. human. [Q92800-3]

    Polymorphism databases

    DMDMi3334182.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U50315 mRNA. Translation: AAC50778.1 .
    AB004818 mRNA. Translation: BAA25019.1 .
    AB002386 mRNA. Translation: BAA20842.2 . Different initiation.
    BT009782 mRNA. Translation: AAP88784.1 .
    AK304835 mRNA. Translation: BAG65579.1 .
    AK295626 mRNA. Translation: BAG58503.1 .
    AK295853 mRNA. Translation: BAG58659.1 .
    AK299887 mRNA. Translation: BAG61734.1 .
    AC100793 Genomic DNA. No translation available.
    CH471152 Genomic DNA. Translation: EAW60870.1 .
    BC015882 mRNA. Translation: AAH15882.1 .
    L38934 mRNA. Translation: AAB59574.1 .
    CCDSi CCDS32659.1. [Q92800-1 ]
    RefSeqi NP_001982.2. NM_001991.3. [Q92800-1 ]
    XP_005257201.1. XM_005257144.1. [Q92800-2 ]
    XP_005257203.1. XM_005257146.1. [Q92800-3 ]
    UniGenei Hs.194669.

    3D structure databases

    ProteinModelPortali Q92800.
    SMRi Q92800. Positions 521-730.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 108445. 10 interactions.
    DIPi DIP-58580N.

    PTM databases

    PhosphoSitei Q92800.

    Polymorphism databases

    DMDMi 3334182.

    Proteomic databases

    MaxQBi Q92800.
    PaxDbi Q92800.
    PRIDEi Q92800.

    Protocols and materials databases

    DNASUi 2145.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000428826 ; ENSP00000404658 ; ENSG00000108799 . [Q92800-1 ]
    ENST00000585893 ; ENSP00000467871 ; ENSG00000108799 . [Q92800-3 ]
    ENST00000590078 ; ENSP00000465220 ; ENSG00000108799 . [Q92800-4 ]
    ENST00000592743 ; ENSP00000466924 ; ENSG00000108799 . [Q92800-1 ]
    GeneIDi 2145.
    KEGGi hsa:2145.
    UCSCi uc002iaz.3. human. [Q92800-1 ]
    uc010cyo.1. human. [Q92800-5 ]
    uc010wgu.2. human. [Q92800-2 ]
    uc010wgv.2. human. [Q92800-3 ]

    Organism-specific databases

    CTDi 2145.
    GeneCardsi GC17M040852.
    HGNCi HGNC:3526. EZH1.
    HPAi HPA005478.
    MIMi 601674. gene.
    neXtProti NX_Q92800.
    PharmGKBi PA27938.
    HUGEi Search...
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG2940.
    HOVERGENi HBG002453.
    InParanoidi Q92800.
    KOi K17451.
    OMAi STQVYNY.
    OrthoDBi EOG7VB2DR.
    PhylomeDBi Q92800.
    TreeFami TF314509.

    Miscellaneous databases

    ChiTaRSi EZH1. human.
    GeneWikii EZH1.
    GenomeRNAii 2145.
    NextBioi 8671.
    PROi Q92800.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92800.
    Bgeei Q92800.
    CleanExi HS_EZH1.
    Genevestigatori Q92800.

    Family and domain databases

    InterProi IPR026489. CXC_dom.
    IPR021654. EZH2_WD-Binding.
    IPR001005. SANT/Myb.
    IPR001214. SET_dom.
    [Graphical view ]
    Pfami PF11616. EZH2_WD-Binding. 1 hit.
    PF00856. SET. 1 hit.
    [Graphical view ]
    SMARTi SM00717. SANT. 2 hits.
    SM00317. SET. 1 hit.
    [Graphical view ]
    PROSITEi PS51633. CXC. 1 hit.
    PS50280. SET. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "Cloning and expression of a human/mouse Polycomb group gene, ENX-2/Enx-2."
      Ogawa M., Hiraoka Y., Taniguchi K., Aiso S.
      Biochim. Biophys. Acta 1395:151-158(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    3. "Prediction of the coding sequences of unidentified human genes. VII. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro."
      Nagase T., Ishikawa K., Nakajima D., Ohira M., Seki N., Miyajima N., Tanaka A., Kotani H., Nomura N., Ohara O.
      DNA Res. 4:141-150(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain.
    4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (AUG-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 2; 3; 4 AND 5).
      Tissue: Brain, Hippocampus and Uterus.
    6. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Uterus.
    9. "Generation of a transcription map at the HSD17B locus centromeric to BRCA1 at 17q21."
      Rommens J.M., Durocher F., McArthur J., Tonin P., Leblanc J.-F., Allen T., Samson C., Ferri L., Narod S., Morgan K., Simard J.
      Genomics 28:530-542(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 434-538.
    10. "Ezh1 and Ezh2 maintain repressive chromatin through different mechanisms."
      Margueron R., Li G., Sarma K., Blais A., Zavadil J., Woodcock C.L., Dynlacht B.D., Reinberg D.
      Mol. Cell 32:503-518(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, CATALYTIC ACTIVITY, SUBCELLULAR LOCATION, IDENTIFICATION IN THE PRC2/EED-EZH1 COMPLEX, MUTAGENESIS OF HIS-690.

    Entry informationi

    Entry nameiEZH1_HUMAN
    AccessioniPrimary (citable) accession number: Q92800
    Secondary accession number(s): A6NCH6
    , B4DIJ1, B4DIZ7, B4DSS2, B4E3R7, O43287, Q14459, Q53XP3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: July 15, 1998
    Last modified: October 1, 2014
    This is version 134 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3