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Protein

Protein translocase subunit SecA 1

Gene

secA1

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Protein inferred from homologyi

Functioni

Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane.UniRule annotation

Cofactori

Zn2+UniRule annotationNote: May bind 1 zinc ion per subunit.UniRule annotation

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi821 – 8211ZincUniRule annotation
Metal bindingi823 – 8231ZincUniRule annotation
Metal bindingi832 – 8321ZincUniRule annotation
Metal bindingi833 – 8331ZincUniRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi100 – 1078ATPUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Protein transport, Translocation, Transport

Keywords - Ligandi

ATP-binding, Metal-binding, Nucleotide-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Protein translocase subunit SecA 1UniRule annotation
Gene namesi
Name:secA1UniRule annotation
Ordered Locus Names:lin2654
OrganismiListeria innocua serovar 6a (strain CLIP 11262)
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

Subcellular locationi

  • Cell membrane UniRule annotation; Peripheral membrane protein UniRule annotation; Cytoplasmic side UniRule annotation
  • Cytoplasm UniRule annotation

  • Note: Distribution is 50-50.UniRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 837837Protein translocase subunit SecA 1PRO_0000109589Add
BLAST

Interactioni

Subunit structurei

Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.UniRule annotation

Protein-protein interaction databases

STRINGi272626.lin2654.

Structurei

3D structure databases

ProteinModelPortaliQ927Y3.
SMRiQ927Y3. Positions 1-800.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SecA family.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218169.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q927Y3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGLLKKIFE SGKKDVKYLE RKADEIIALA DETAALSDEA LREKTVEFKE
60 70 80 90 100
RVQKGETLDD LLVEAFAVAR EGAKRALGLY PFKVQLMGGI VLHEGNIAEM
110 120 130 140 150
KTGEGKTLTA TLPVYLNALS GEGVHVVTVN EYLAHRDAEE MGVLYNFLGL
160 170 180 190 200
SVGLNLNALS STEKREAYAC DITYSTNNEL GFDYLRDNMV VYKEEMVQRP
210 220 230 240 250
LAFAVIDEVD SILVDEARTP LIISGEAEKS TILYVRANTF VRTLTEEEDY
260 270 280 290 300
TVDIKTKSVQ LTEDGMTKGE NYFDVENLFD LENTVILHHI AQALKANYTM
310 320 330 340 350
SLDVDYVVQD DEVLIVDQFT GRIMKGRRFS EGLHQALEAK EGVTIQNESK
360 370 380 390 400
TMATITFQNY FRMYKKLAGM TGTAKTEEEE FRDIYNMRVI EIPTNKVIIR
410 420 430 440 450
DDRPDLIFTT IEAKFNAVVE DIADRHAKGQ PVLVGTVAIE TSELISSKLK
460 470 480 490 500
RKGIKHDVLN AKQHEREADI IKNAGERGAV TIATNMAGRG TDIKLGEGTI
510 520 530 540 550
DAGGLAVIGT ERHESRRIDN QLRGRSGRQG DPGVTQFYLS MEDELMRRFG
560 570 580 590 600
SDNMKSMMER FGMAEDAIQS KMVSRAVESA QRRVEGNNFD SRKQVLQYDD
610 620 630 640 650
VLRQQREVIY KQRYEVINAE NSLREIIEQM IQRTVNFIVS SNASSHEPEE
660 670 680 690 700
AWNLQGIIDY VDANLLPEGT ITLEDLQNRT SEDIQNLILD KIKAAYDEKE
710 720 730 740 750
TLLPPEEFNE FEKVVLLRVV DTKWVDHIDA MDHLRDGIHL RAYGQIDPLR
760 770 780 790 800
EYQSEGFEMF EAMVSSIDED VARYIMKAEI RQNLEREQVA KGEAINPAEG
810 820 830
KPEAKRQPVR KDQHIGRNDP CPCGSGKKYK NCHGKEA
Length:837
Mass (Da):94,594
Last modified:December 1, 2001 - v1
Checksum:i5A6065D916DB3C26
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596173 Genomic DNA. Translation: CAC97880.1.
PIRiAH1763.
RefSeqiWP_003772328.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC97880; CAC97880; CAC97880.
KEGGilin:secA.
PATRICi20302223. VBILisInn102668_2724.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596173 Genomic DNA. Translation: CAC97880.1.
PIRiAH1763.
RefSeqiWP_003772328.1. NC_003212.1.

3D structure databases

ProteinModelPortaliQ927Y3.
SMRiQ927Y3. Positions 1-800.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272626.lin2654.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC97880; CAC97880; CAC97880.
KEGGilin:secA.
PATRICi20302223. VBILisInn102668_2724.

Phylogenomic databases

eggNOGiENOG4105CI6. Bacteria.
COG0653. LUCA.
HOGENOMiHOG000218169.
KOiK03070.
OMAiIATERHE.
OrthoDBiEOG654P48.

Family and domain databases

Gene3Di1.10.3060.10. 1 hit.
3.40.50.300. 3 hits.
3.90.1440.10. 1 hit.
HAMAPiMF_01382. SecA.
InterProiIPR027417. P-loop_NTPase.
IPR004027. SEC_C_motif.
IPR000185. SecA.
IPR020937. SecA_CS.
IPR011115. SecA_DEAD.
IPR014018. SecA_motor_DEAD.
IPR011130. SecA_preprotein_X-link_dom.
IPR011116. SecA_Wing/Scaffold.
[Graphical view]
PfamiPF02810. SEC-C. 1 hit.
PF07517. SecA_DEAD. 1 hit.
PF01043. SecA_PP_bind. 1 hit.
PF07516. SecA_SW. 1 hit.
[Graphical view]
PRINTSiPR00906. SECA.
SMARTiSM00957. SecA_DEAD. 1 hit.
SM00958. SecA_PP_bind. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
SSF81767. SSF81767. 1 hit.
SSF81886. SSF81886. 1 hit.
TIGRFAMsiTIGR00963. secA. 1 hit.
PROSITEiPS01312. SECA. 1 hit.
PS51196. SECA_MOTOR_DEAD. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262.

Entry informationi

Entry nameiSECA1_LISIN
AccessioniPrimary (citable) accession number: Q927Y3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 23, 2002
Last sequence update: December 1, 2001
Last modified: May 11, 2016
This is version 101 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.