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Protein

o-succinylbenzoate synthase

Gene

menC

Organism
Listeria innocua serovar 6a (strain CLIP 11262)
Status
Unreviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB).UniRule annotationSAAS annotation

Catalytic activityi

(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate = 2-succinylbenzoate + H2O.UniRule annotationSAAS annotation

Cofactori

a divalent metal cationUniRule annotation

Pathwayi: 1,4-dihydroxy-2-naphthoate biosynthesis

This protein is involved in step 4 of the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate.UniRule annotationSAAS annotation
Proteins known to be involved in the 7 steps of the subpathway in this organism are:
  1. no protein annotated in this organism
  2. 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate synthase (menD)
  3. Putative 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate synthase (menH)
  4. o-succinylbenzoate synthase (menC)
  5. 2-succinylbenzoate--CoA ligase (menE)
  6. 1,4-dihydroxy-2-naphthoyl-CoA synthase (menB)
  7. no protein annotated in this organism
This subpathway is part of the pathway 1,4-dihydroxy-2-naphthoate biosynthesis, which is itself part of Quinol/quinone metabolism.
View all proteins of this organism that are known to be involved in the subpathway that synthesizes 1,4-dihydroxy-2-naphthoate from chorismate, the pathway 1,4-dihydroxy-2-naphthoate biosynthesis and in Quinol/quinone metabolism.

Pathwayi: menaquinone biosynthesis

This protein is involved in the pathway menaquinone biosynthesis, which is part of Quinol/quinone metabolism.UniRule annotationSAAS annotation
View all proteins of this organism that are known to be involved in the pathway menaquinone biosynthesis and in Quinol/quinone metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei162 – 1621Proton donorUniRule annotation
Metal bindingi189 – 1891MagnesiumUniRule annotation
Metal bindingi214 – 2141MagnesiumUniRule annotation
Metal bindingi239 – 2391MagnesiumUniRule annotation
Active sitei263 – 2631Proton acceptorUniRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

LyaseUniRule annotationSAAS annotation

Keywords - Biological processi

Menaquinone biosynthesisUniRule annotationSAAS annotation

Keywords - Ligandi

MagnesiumUniRule annotationSAAS annotation, Metal-bindingUniRule annotationSAAS annotation

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Names & Taxonomyi

Protein namesi
Recommended name:
o-succinylbenzoate synthaseUniRule annotationSAAS annotation (EC:4.2.1.113UniRule annotationSAAS annotation)
Short name:
OSB synthaseUniRule annotation
Short name:
OSBSUniRule annotation
Alternative name(s):
4-(2'-carboxyphenyl)-4-oxybutyric acid synthaseUniRule annotation
o-succinylbenzoic acid synthaseUniRule annotation
Gene namesi
Name:menCUniRule annotation
Ordered Locus Names:lin2664Imported
OrganismiListeria innocua serovar 6a (strain CLIP 11262)Imported
Taxonomic identifieri272626 [NCBI]
Taxonomic lineageiBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria
Proteomesi
  • UP000002513 Componenti: Chromosome

Interactioni

Protein-protein interaction databases

STRINGi272626.lin2664.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WUFX-ray2.90A/B1-374[»]
ProteinModelPortaliQ927X3.
SMRiQ927X3. Positions 1-370.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ927X3.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini143 – 23593MR_MLEInterPro annotationAdd
BLAST

Sequence similaritiesi

Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.UniRule annotation

Phylogenomic databases

eggNOGiENOG4105DTQ. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000185900.
KOiK02549.
OMAiDDIVDHR.
OrthoDBiEOG6091BS.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01933. MenC_2.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
IPR010197. OSB_synthase_MenC_2.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01928. menC_lowGC/arch. 1 hit.

Sequencei

Sequence statusi: Complete.

Q927X3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MYFQKARLIH AELPLLAPFK TSYGELKSKD FYIIELINEE GIHGYGELEA
60 70 80 90 100
FPLPDYTEET LSSAILIIKE QLLPLLAQRK IRKPEEIQEL FSWIQGNEMA
110 120 130 140 150
KAAVELAVWD AFAKMEKRSL AKMIGATKES IKVGVSIGLQ QNVETLLQLV
160 170 180 190 200
NQYVDQGYER VKLKIAPNKD IQFVEAVRKS FPKLSLMADA NSAYNREDFL
210 220 230 240 250
LLKELDQYDL EMIEQPFGTK DFVDHAWLQK QLKTRICLDE NIRSVKDVEQ
260 270 280 290 300
AHSIGSCRAI NLKLARVGGM SSALKIAEYC ALNEILVWCG GMLEAGVGRA
310 320 330 340 350
HNIALAARNE FVFPGDISAS NRFFAEDIVT PAFELNQGRL KVPTNEGIGV
360 370
TLDLKVLKKY TKSTEEILLN KGWS
Length:374
Mass (Da):42,175
Last modified:December 1, 2001 - v1
Checksum:i7670999F7CC12471
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596173 Genomic DNA. Translation: CAC97890.1.
PIRiAB1765.
RefSeqiWP_010991324.1. NC_003212.1.

Genome annotation databases

EnsemblBacteriaiCAC97890; CAC97890; CAC97890.
KEGGilin:lin2664.
PATRICi20302243. VBILisInn102668_2734.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AL596173 Genomic DNA. Translation: CAC97890.1.
PIRiAB1765.
RefSeqiWP_010991324.1. NC_003212.1.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
1WUFX-ray2.90A/B1-374[»]
ProteinModelPortaliQ927X3.
SMRiQ927X3. Positions 1-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi272626.lin2664.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaiCAC97890; CAC97890; CAC97890.
KEGGilin:lin2664.
PATRICi20302243. VBILisInn102668_2734.

Phylogenomic databases

eggNOGiENOG4105DTQ. Bacteria.
COG4948. LUCA.
HOGENOMiHOG000185900.
KOiK02549.
OMAiDDIVDHR.
OrthoDBiEOG6091BS.

Enzyme and pathway databases

UniPathwayiUPA00079.
UPA01057; UER00165.

Miscellaneous databases

EvolutionaryTraceiQ927X3.

Family and domain databases

Gene3Di3.20.20.120. 1 hit.
3.30.390.10. 1 hit.
HAMAPiMF_01933. MenC_2.
InterProiIPR029065. Enolase_C-like.
IPR029017. Enolase_N-like.
IPR013342. Mandelate_racemase_C.
IPR013341. Mandelate_racemase_N_dom.
IPR001354. MR/MLE/MAL.
IPR010197. OSB_synthase_MenC_2.
[Graphical view]
PANTHERiPTHR13794. PTHR13794. 1 hit.
PTHR13794:SF8. PTHR13794:SF8. 1 hit.
PfamiPF13378. MR_MLE_C. 1 hit.
PF02746. MR_MLE_N. 1 hit.
[Graphical view]
SMARTiSM00922. MR_MLE. 1 hit.
[Graphical view]
SUPFAMiSSF51604. SSF51604. 1 hit.
SSF54826. SSF54826. 1 hit.
TIGRFAMsiTIGR01928. menC_lowGC/arch. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: CLIP 11262Imported.
  2. Cited for: X-RAY CRYSTALLOGRAPHY (2.90 ANGSTROMS).

Entry informationi

Entry nameiQ927X3_LISIN
AccessioniPrimary (citable) accession number: Q927X3
Entry historyi
Integrated into UniProtKB/TrEMBL: December 1, 2001
Last sequence update: December 1, 2001
Last modified: June 8, 2016
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

3D-structureCombined sources, Complete proteomeImported

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.