Reviewed, UniProtKB/Swiss-Prot Q927W7 (MURA1_LISIN)

Names and origin

Protein names

Recommended name:
    UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1
    EC=2.5.1.7
Alternative name(s):
    Enoylpyruvate transferase 1
    UDP-N-acetylglucosamine enolpyruvyl transferase 1
      Short name=EPT 1

Gene names

Name:	murA1
Synonyms:	murA
Ordered Locus Names:	lin2670

Organism

Listeria innocua [Complete proteome] [HAMAP]

Taxonomic identifier

1642 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Bacillales › Listeriaceae › Listeria

Protein attributes

Sequence length	430 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine By similarity.
Catalytic activity	Phosphoenolpyruvate + UDP-N-acetyl-D-glucosamine = phosphate + UDP-N-acetyl-3-O-(1-carboxyvinyl)-D-glucosamine. HAMAP MF_00111
Pathway	Cell wall biogenesis; peptidoglycan biosynthesis. HAMAP MF_00111
Subcellular location	Cytoplasm Probable.
Sequence similarities	Belongs to the EPSP synthase family. MurA subfamily.

Ontologies

Keywords
Biological process	Cell cycle Cell division Cell shape Cell wall biogenesis/degradation Peptidoglycan synthesis
Cellular component	Cytoplasm
Molecular function	Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-N-acetylgalactosamine biosynthetic process Inferred from electronic annotation. Source: InterPro cell cycle Inferred from electronic annotation. Source: UniProtKB-KW cell division Inferred from electronic annotation. Source: UniProtKB-KW cell wall organization Inferred from electronic annotation. Source: UniProtKB-KW peptidoglycan biosynthetic process Inferred from electronic annotation. Source: HAMAP regulation of cell shape Inferred from electronic annotation. Source: UniProtKB-KW
Cellular component	cytoplasm Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	UDP-N-acetylglucosamine 1-carboxyvinyltransferase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 430	430	UDP-N-acetylglucosamine 1-carboxyvinyltransferase 1 HAMAP MF_00111		PRO_0000178883
Sites
	Active site	117	1	Proton donor By similarity
	Binding site	117	1	Phosphoenolpyruvate (covalent) By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q927W7-1 [UniParc]. Last modified December 1, 2001. Version 1. Checksum: DB3085BA7FC70CEF	FASTA	430	46,007
	10 20 30 40 50 60 MEKIIVRGGK QLNGSVKMEG AKNAVLPVIA ATLLASKGTS VLKNVPNLSD VFTINEVLKY 70 80 90 100 110 120 LNADVSFVND EVTVDATGEI TSDAPFEYVR KMRASIVVMG PLLARTGSAR VALPGGCAIG 130 140 150 160 170 180 SRPVDLHLKG FEAMGAIVKI ENGYIEATAE KLVGAKVYLD FPSVGATQNI MMAATLAEGT 190 200 210 220 230 240 TVIENVAREP EIVDLANFLN QMGARVIGAG TEVIRIEGVK ELTATEHSII PDRIEAGTFM 250 260 270 280 290 300 IAAAITGGNV LIEDAVPEHI SSLIAKLEEM GVQIIEEENG IRVIGPDKLK AVDVKTMPHP 310 320 330 340 350 360 GFPTDMQSQM MVIQMLSEGT SIMTETVFEN RFMHVEEMRR MNADMKIEGH SVIISGPAKL 370 380 390 400 410 420 QGAEVAATDL RAAAALILAG LVADGYTQVT ELKYLDRGYN NFHGKLQALG ADVERVDDSK 430 IDVTNLASLF

References

[1]

"Comparative genomics of Listeria species." Glaser P., Frangeul L., Buchrieser C., Rusniok C., Amend A., Baquero F., Berche P., Bloecker H., Brandt P., Chakraborty T., Charbit A., Chetouani F., Couve E., de Daruvar A., Dehoux P., Domann E., Dominguez-Bernal G., Duchaud E. , Durant L., Dussurget O., Entian K.-D., Fsihi H., Garcia-del Portillo F., Garrido P., Gautier L., Goebel W., Gomez-Lopez N., Hain T., Hauf J., Jackson D., Jones L.-M., Kaerst U., Kreft J., Kuhn M., Kunst F., Kurapkat G., Madueno E., Maitournam A., Mata Vicente J., Ng E., Nedjari H., Nordsiek G., Novella S., de Pablos B., Perez-Diaz J.-C., Purcell R., Remmel B., Rose M., Schlueter T., Simoes N., Tierrez A., Vazquez-Boland J.-A., Voss H., Wehland J., Cossart P. Science 294:849-852(2001) [PubMed: 11679669] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: CLIP 11262 / Serovar 6a.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AL596173 Genomic DNA. Translation: CAC97896.1.
PIR	AH1765.
RefSeq	NP_471999.1.
3D structure databases
HSSP	HSSP built from PDB template 1DLG based on UniProtKB P33038.
ModBase	Search...
Genome annotation databases
GeneID	1131510.
GenomeReviews	Gene locus lin2670 in contig AL592022_GR.
KEGG	lin:lin2670.
NMPDR	fig|272626.1.peg.2652.
Organism-specific databases
ListiList	LIN02670.
CMR	Search...
Phylogenomic databases
HOGENOM	Q927W7.
OMA	VSRVYHL.
Enzyme and pathway databases
BioCyc	LINN272626:LIN2670-MON.
BRENDA	2.5.1.7. 270396.
Family and domain databases
HAMAP	MF_00111. [Tree]
InterPro	IPR001986. EPSP_synthase_core. IPR005750. UDP_GlcNAc_COvinyl_MurA. [Graphical view]
Gene3D	G3DSA:3.65.10.10. EPSP_synthase. 2 hits.
PANTHER	PTHR21090:SF4. AcGlu_Tran_MurA. 1 hit.
Pfam	PF00275. EPSP_synthase. 1 hit. [Graphical view]
ProDom	PD001867. EPSP_synth. 1 hit. [Graphical view] [Entries sharing at least one domain]
TIGRFAMs	TIGR01072. murA. 1 hit.
ProtoNet	Search...

Entry information

Entry name

MURA1_LISIN

Accession

Primary (citable) accession number: Q927W7

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2002
Last sequence update:	December 1, 2001
Last modified:	November 3, 2009
This is version 54 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)