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Q927U9 (KITH_LISIN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 66. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Thymidine kinase

EC=2.7.1.21
Gene names
Name:tdk
Ordered Locus Names:lin2688
OrganismListeria innocua serovar 6a (strain CLIP 11262) [Complete proteome] [HAMAP]
Taxonomic identifier272626 [NCBI]
Taxonomic lineageBacteriaFirmicutesBacilliBacillalesListeriaceaeListeria

Protein attributes

Sequence length191 AA.
Sequence statusComplete.
Protein existenceInferred from homology

General annotation (Comments)

Catalytic activity

ATP + thymidine = ADP + thymidine 5'-phosphate. HAMAP-Rule MF_00124

Subunit structure

Homotetramer By similarity. HAMAP-Rule MF_00124

Subcellular location

Cytoplasm Potential HAMAP-Rule MF_00124.

Sequence similarities

Belongs to the thymidine kinase family.

Ontologies

Keywords
   Biological processDNA synthesis
   Cellular componentCytoplasm
   LigandATP-binding
Metal-binding
Nucleotide-binding
Zinc
   Molecular functionKinase
Transferase
   Technical termComplete proteome
Gene Ontology (GO)
   Biological_processDNA replication

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentcytoplasm

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

thymidine kinase activity

Inferred from electronic annotation. Source: UniProtKB-HAMAP

zinc ion binding

Inferred from electronic annotation. Source: UniProtKB-HAMAP

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 191191Thymidine kinase HAMAP-Rule MF_00124
PRO_0000174988

Regions

Nucleotide binding9 – 168ATP By similarity
Nucleotide binding85 – 884ATP By similarity

Sites

Active site861Proton acceptor Potential
Metal binding1431Zinc By similarity
Metal binding1461Zinc By similarity
Metal binding1811Zinc By similarity
Metal binding1841Zinc By similarity

Sequences

Sequence LengthMass (Da)Tools
Q927U9 [UniParc].

Last modified December 1, 2001. Version 1.
Checksum: A9E9CE8A0853A089

FASTA19121,835
        10         20         30         40         50         60 
MAQLFFRYGS MNSGKTIEIL KVAHNYEEQN KTVAIFTSGI DDRDQVGFIS SRIGLKREAT 

        70         80         90        100        110        120 
PIFSDTNIFE IVANIKPKPN CVLLDESQFL EKEHVFQLAK IVDDLNIPVI AYGLKNDFRN 

       130        140        150        160        170        180 
ELFEGSKYLL LYADKLEEMK TICWFCAKKA TMVLRVDDKG KPVYTGEQIM IGGNDHYYPV 

       190 
CRKCHANPPI K 

« Hide

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AL596173 Genomic DNA. Translation: CAC97914.1.
PIRAB1768.
RefSeqNP_472017.1. NC_003212.1.

3D structure databases

ProteinModelPortalQ927U9.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING272626.lin2688.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblBacteriaCAC97914; CAC97914; CAC97914.
GeneID1131532.
KEGGlin:lin2688.
PATRIC20302291. VBILisInn102668_2758.

Organism-specific databases

GenoListLIN2688.
CMRSearch...

Phylogenomic databases

eggNOGCOG1435.
HOGENOMHOG000076391.
KOK00857.
OMARTICHCG.
OrthoDBEOG69D3J2.
ProtClustDBPRK04296.

Family and domain databases

Gene3D3.40.50.300. 1 hit.
HAMAPMF_00124. Thymidine_kinase.
InterProIPR027417. P-loop_NTPase.
IPR001267. Thymidine_kinase.
IPR020633. Thymidine_kinase_CS.
IPR020634. Thymidine_kinase_subgr.
[Graphical view]
PANTHERPTHR11441. PTHR11441. 1 hit.
PfamPF00265. TK. 1 hit.
[Graphical view]
PIRSFPIRSF035805. TK_cell. 1 hit.
SUPFAMSSF52540. SSF52540. 1 hit.
PROSITEPS00603. TK_CELLULAR_TYPE. 1 hit.
[Graphical view]
ProtoNetSearch...

Entry information

Entry nameKITH_LISIN
AccessionPrimary (citable) accession number: Q927U9
Entry history
Integrated into UniProtKB/Swiss-Prot: October 31, 2003
Last sequence update: December 1, 2001
Last modified: April 16, 2014
This is version 66 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programProkaryotic Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families