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Protein

Synaptonemal complex protein SC65

Gene

P3H4

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

GO - Biological processi

  • synaptonemal complex assembly Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Synaptonemal complex protein SC65By similarity
Alternative name(s):
Leprecan-like protein 4
Nucleolar autoantigen No552 Publications
Prolyl 3-hydroxylase family member 4Imported
Gene namesi
Name:P3H4Imported
Synonyms:LEPREL4, NOL55, SC65By similarity
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:16946. P3H4.

Subcellular locationi

GO - Cellular componenti

  • condensed nuclear chromosome Source: ProtInc
  • nucleolus Source: ProtInc
  • synaptonemal complex Source: ProtInc
Complete GO annotation...

Keywords - Cellular componenti

Chromosome, Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

BioMutaiLEPREL4.
DMDMi3183090.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 437437Synaptonemal complex protein SC65PRO_0000150367Add
BLAST

Proteomic databases

EPDiQ92791.
MaxQBiQ92791.
PaxDbiQ92791.
PRIDEiQ92791.

PTM databases

PhosphoSiteiQ92791.

Expressioni

Gene expression databases

BgeeiQ92791.
ExpressionAtlasiQ92791. baseline and differential.
GenevisibleiQ92791. HS.

Organism-specific databases

HPAiHPA022520.
HPA057287.

Interactioni

Protein-protein interaction databases

BioGridi115855. 22 interactions.
STRINGi9606.ENSP00000347649.

Structurei

3D structure databases

ProteinModelPortaliQ92791.
SMRiQ92791. Positions 36-66.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi346 – 43792Asp/Glu-rich (acidic)Add
BLAST

Sequence similaritiesi

Belongs to the leprecan family.Curated

Phylogenomic databases

eggNOGiKOG4459. Eukaryota.
ENOG410XPXF. LUCA.
GeneTreeiENSGT00550000074573.
HOGENOMiHOG000247068.
HOVERGENiHBG005540.
InParanoidiQ92791.
OMAiYYRFYRE.
OrthoDBiEOG7F7W8W.
PhylomeDBiQ92791.
TreeFamiTF320837.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR033213. SC65.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13986:SF4. PTHR13986:SF4. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92791-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARVAWGLLW LLLGSAGAQY EKYSFRGFPP EDLMPLAAAY GHALEQYEGE
60 70 80 90 100
SWRESARYLE AALRLHRLLR DSEAFCHANC SGPAPAAKPD PDGGRADEWA
110 120 130 140 150
CELRLFGRVL ERAACLRRCK RTLPAFQVPY PPRQLLRDFQ SRLPYQYLHY
160 170 180 190 200
ALFKANRLEK AVAAAYTFLQ RNPKHELTAK YLNYYQGMLD VADESLTDLE
210 220 230 240 250
AQPYEAVFLR AVKLYNSGDF RSSTEDMERA LSEYLAVFAR CLAGCEGAHE
260 270 280 290 300
QVDFKDFYPA IADLFAESLQ CKVDCEANLT PNVGGYFVDK FVATMYHYLQ
310 320 330 340 350
FAYYKLNDVR QAARSAASYM LFDPKDSVMQ QNLVYYRFHR ARWGLEEEDF
360 370 380 390 400
QPREEAMLYH NQTAELRELL EFTHMYLQSD DEMELEETEP PLEPEDALSD
410 420 430
AEFEGEGDYE EGMYADWWQE PDAKGDEAEA EPEPELA
Length:437
Mass (Da):50,381
Last modified:February 1, 1997 - v1
Checksum:i50C82FCE9BB7274A
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti186 – 1861Q → R.2 Publications
Corresponds to variant rs13412 [ dbSNP | Ensembl ].
VAR_020417

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47621 mRNA. Translation: AAC51792.1.
AJ250583 mRNA. Translation: CAC16786.1.
AK222945 mRNA. Translation: BAD96665.1.
BC001047 mRNA. Translation: AAH01047.1.
BC007942 mRNA. Translation: AAH07942.1.
BC011701 mRNA. Translation: AAH11701.1.
CCDSiCCDS11408.1.
RefSeqiNP_006446.1. NM_006455.2.
UniGeneiHs.446459.

Genome annotation databases

EnsembliENST00000355468; ENSP00000347649; ENSG00000141696.
ENST00000393928; ENSP00000377505; ENSG00000141696.
GeneIDi10609.
KEGGihsa:10609.
UCSCiuc002hxt.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U47621 mRNA. Translation: AAC51792.1.
AJ250583 mRNA. Translation: CAC16786.1.
AK222945 mRNA. Translation: BAD96665.1.
BC001047 mRNA. Translation: AAH01047.1.
BC007942 mRNA. Translation: AAH07942.1.
BC011701 mRNA. Translation: AAH11701.1.
CCDSiCCDS11408.1.
RefSeqiNP_006446.1. NM_006455.2.
UniGeneiHs.446459.

3D structure databases

ProteinModelPortaliQ92791.
SMRiQ92791. Positions 36-66.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115855. 22 interactions.
STRINGi9606.ENSP00000347649.

PTM databases

PhosphoSiteiQ92791.

Polymorphism and mutation databases

BioMutaiLEPREL4.
DMDMi3183090.

Proteomic databases

EPDiQ92791.
MaxQBiQ92791.
PaxDbiQ92791.
PRIDEiQ92791.

Protocols and materials databases

DNASUi10609.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000355468; ENSP00000347649; ENSG00000141696.
ENST00000393928; ENSP00000377505; ENSG00000141696.
GeneIDi10609.
KEGGihsa:10609.
UCSCiuc002hxt.4. human.

Organism-specific databases

CTDi10609.
GeneCardsiP3H4.
HGNCiHGNC:16946. P3H4.
HPAiHPA022520.
HPA057287.
neXtProtiNX_Q92791.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4459. Eukaryota.
ENOG410XPXF. LUCA.
GeneTreeiENSGT00550000074573.
HOGENOMiHOG000247068.
HOVERGENiHBG005540.
InParanoidiQ92791.
OMAiYYRFYRE.
OrthoDBiEOG7F7W8W.
PhylomeDBiQ92791.
TreeFamiTF320837.

Miscellaneous databases

ChiTaRSiLEPREL4. human.
GeneWikiiSC65.
GenomeRNAii10609.
NextBioi40296.
PROiQ92791.

Gene expression databases

BgeeiQ92791.
ExpressionAtlasiQ92791. baseline and differential.
GenevisibleiQ92791. HS.

Family and domain databases

Gene3Di1.25.40.10. 3 hits.
InterProiIPR033213. SC65.
IPR011990. TPR-like_helical_dom.
[Graphical view]
PANTHERiPTHR13986:SF4. PTHR13986:SF4. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "cDNA cloning and characterization of a novel nucleolar protein."
    Ochs R.L., Stein T.W. Jr., Chan E.K.L., Ruutu M., Tan E.M.
    Mol. Biol. Cell 7:1015-1024(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], SUBCELLULAR LOCATION.
    Tissue: Urinary bladder urothelium.
  2. "Identification of nucleolar protein No55 as a tumour-associated autoantigen in patients with prostate cancer."
    Fossa A., Siebert R., Aasheim H.-C., Maelandsmo G.M., Berner A., Fossa S.D., Paus E., Smeland E.B., Gaudernack G.
    Br. J. Cancer 83:743-749(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], VARIANT ARG-186.
  3. Suzuki Y., Sugano S., Totoki Y., Toyoda A., Takeda T., Sakaki Y., Tanaka A., Yokoyama S.
    Submitted (APR-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA], VARIANT ARG-186.
    Tissue: Kidney.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. Bienvenut W.V., Dhillon A.S., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 58-64; 122-133; 161-171; 214-221; 230-240 AND 315-337, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Hepatoma.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiSC65_HUMAN
AccessioniPrimary (citable) accession number: Q92791
Secondary accession number(s): Q53GI6, Q9H4F6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: May 11, 2016
This is version 125 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.