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Q92786

- PROX1_HUMAN

UniProt

Q92786 - PROX1_HUMAN

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Protein

Prospero homeobox protein 1

Gene

PROX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Transcription factor involved in developmental processes such as cell fate determination, gene transcriptional regulation and progenitor cell regulation in a number of organs. Plays a critical role in embryonic development and functions as a key regulatory protein in neurogenesis and the development of the heart, eye lens, liver, pancreas and the lymphatic system. Involved in the regulation of the circadian rhythm. Represses: transcription of the retinoid-related orphan receptor RORG, transcriptional activator activity of RORA and RORG and the expression of RORA/G-target genes including core clock components: ARNTL/BMAL1, NPAS2 and CRY1 and metabolic genes: AVPR1A and ELOVL3.1 Publication1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi573 – 63563Prospero-type homeoboxAdd
BLAST

GO - Molecular functioni

  1. core promoter sequence-specific DNA binding Source: UniProtKB
  2. DBD domain binding Source: BHF-UCL
  3. DNA binding Source: BHF-UCL
  4. LBD domain binding Source: BHF-UCL
  5. ligand-dependent nuclear receptor binding Source: BHF-UCL
  6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  7. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  8. transcription corepressor activity Source: BHF-UCL
  9. transcription regulatory region DNA binding Source: BHF-UCL

GO - Biological processi

  1. aorta smooth muscle tissue morphogenesis Source: BHF-UCL
  2. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
  3. brain development Source: BHF-UCL
  4. cell fate determination Source: Ensembl
  5. cerebellar granule cell differentiation Source: BHF-UCL
  6. dentate gyrus development Source: BHF-UCL
  7. dorsal spinal cord development Source: BHF-UCL
  8. embryonic retina morphogenesis in camera-type eye Source: BHF-UCL
  9. endocardium formation Source: BHF-UCL
  10. hepatocyte cell migration Source: Ensembl
  11. hepatocyte differentiation Source: BHF-UCL
  12. hepatocyte proliferation Source: Ensembl
  13. kidney development Source: BHF-UCL
  14. lens development in camera-type eye Source: BHF-UCL
  15. lens fiber cell morphogenesis Source: BHF-UCL
  16. liver development Source: BHF-UCL
  17. lung development Source: BHF-UCL
  18. lymphangiogenesis Source: BHF-UCL
  19. lymphatic endothelial cell differentiation Source: BHF-UCL
  20. negative regulation of bile acid biosynthetic process Source: BHF-UCL
  21. negative regulation of cell proliferation Source: BHF-UCL
  22. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  23. negative regulation of transcription, DNA-templated Source: UniProtKB
  24. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  25. negative regulation of viral genome replication Source: BHF-UCL
  26. neural tube development Source: BHF-UCL
  27. neuronal stem cell maintenance Source: BHF-UCL
  28. olfactory placode formation Source: BHF-UCL
  29. optic placode formation involved in camera-type eye formation Source: BHF-UCL
  30. otic placode formation Source: BHF-UCL
  31. pancreas development Source: BHF-UCL
  32. positive regulation of cell cycle Source: BHF-UCL
  33. positive regulation of cell cycle checkpoint Source: Ensembl
  34. positive regulation of cell proliferation Source: BHF-UCL
  35. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
  36. positive regulation of endothelial cell migration Source: BHF-UCL
  37. positive regulation of endothelial cell proliferation Source: BHF-UCL
  38. positive regulation of forebrain neuron differentiation Source: BHF-UCL
  39. positive regulation of heart growth Source: BHF-UCL
  40. positive regulation of neural precursor cell proliferation Source: BHF-UCL
  41. positive regulation of sarcomere organization Source: BHF-UCL
  42. positive regulation of transcription, DNA-templated Source: BHF-UCL
  43. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
  44. regulation of circadian rhythm Source: UniProtKB
  45. regulation of gene expression Source: BHF-UCL
  46. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: BHF-UCL
  47. response to nutrient levels Source: Ensembl
  48. retina morphogenesis in camera-type eye Source: BHF-UCL
  49. skeletal muscle thin filament assembly Source: BHF-UCL
  50. venous blood vessel morphogenesis Source: BHF-UCL
  51. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
  52. ventricular cardiac myofibril assembly Source: BHF-UCL
  53. ventricular septum morphogenesis Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Repressor

Keywords - Biological processi

Biological rhythms, Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Prospero homeobox protein 1
Alternative name(s):
Homeobox prospero-like protein PROX1
Short name:
PROX-1
Gene namesi
Name:PROX1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 1

Organism-specific databases

HGNCiHGNC:9459. PROX1.

Subcellular locationi

Nucleus By similarity
Note: RORG promotes its nuclear localization.By similarity

GO - Cellular componenti

  1. cytoplasm Source: BHF-UCL
  2. nucleus Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA33812.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 737737Prospero homeobox protein 1PRO_0000208880Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei179 – 1791PhosphoserineBy similarity
Modified residuei511 – 5111PhosphoserineBy similarity
Modified residuei514 – 5141PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92786.
PaxDbiQ92786.
PRIDEiQ92786.

PTM databases

PhosphoSiteiQ92786.

Expressioni

Tissue specificityi

Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.1 Publication

Gene expression databases

BgeeiQ92786.
CleanExiHS_PROX1.
ExpressionAtlasiQ92786. baseline and differential.
GenevestigatoriQ92786.

Interactioni

Subunit structurei

Interacts with RORA and RORG (via AF-2 motif).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
CTBP2P565452EBI-3912635,EBI-741533
HNF1AP208233EBI-3912635,EBI-636034
NR5A2O00482-29EBI-3912635,EBI-9257474

Protein-protein interaction databases

BioGridi111613. 16 interactions.
IntActiQ92786. 8 interactions.
MINTiMINT-2813285.
STRINGi9606.ENSP00000261454.

Structurei

Secondary structure

1
737
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi582 – 59211Combined sources
Helixi599 – 6068Combined sources
Helixi614 – 64532Combined sources
Helixi650 – 6523Combined sources
Beta strandi653 – 6564Combined sources
Helixi660 – 66910Combined sources
Helixi679 – 69820Combined sources
Helixi705 – 71511Combined sources
Helixi728 – 7303Combined sources
Helixi732 – 7343Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
2LMDNMR-A575-737[»]
ProteinModelPortaliQ92786.
SMRiQ92786. Positions 575-737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2828Interaction with RORGBy similarityAdd
BLAST
Regioni636 – 737102Prospero-likeAdd
BLAST
Regioni723 – 7297Essential for nuclear localization, interaction with RORG, repression of RORG transcriptional activator activityBy similarity

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi215 – 2195Poly-Gln

Domaini

The prospero-type homeobox DNA-binding domain is essential for repression of RORG transcriptional activator activity.By similarity

Sequence similaritiesi

Belongs to the Prospero homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG323972.
GeneTreeiENSGT00530000063507.
HOGENOMiHOG000115708.
HOVERGENiHBG053693.
InParanoidiQ92786.
OMAiQECLSPF.
OrthoDBiEOG7MSMNK.
PhylomeDBiQ92786.
TreeFamiTF316638.

Family and domain databases

Gene3Di1.10.10.500. 1 hit.
InterProiIPR023082. Homeo_prospero_dom.
IPR009057. Homeodomain-like.
IPR007738. Prox1.
[Graphical view]
PANTHERiPTHR12198. PTHR12198. 1 hit.
PfamiPF05044. HPD. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92786-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS
60 70 80 90 100
EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN
110 120 130 140 150
MNKNGGTEPS FQASGLSSTG SEVHQEDICS NSSRDSPPEC LSPFGRPTMS
160 170 180 190 200
QFDMDRLCDE HLRAKRARVE NIIRGMSHSP SVALRGNENE REMAPQSVSP
210 220 230 240 250
RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK QQLEDMQKQL
260 270 280 290 300
RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC
310 320 330 340 350
ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE
360 370 380 390 400
TLKQELNTAM SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH
410 420 430 440 450
NFHTANQRLQ CFGDVIIPNP LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ
460 470 480 490 500
SASGPAAGGH HQPLHQSPLS ATTGFTTSTF RHPFPLPLMA YPFQSPLGAP
510 520 530 540 550
SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP AHPPSTAEGL
560 570 580 590 600
SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS
610 620 630 640 650
NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST
660 670 680 690 700
EELSITRDCE LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK
710 720 730
DVDPSWKKAI YKVICKLDSE VPEIFKSPNC LQELLHE
Length:737
Mass (Da):83,203
Last modified:September 13, 2005 - v2
Checksum:iD243CEB421B313CA
GO

Sequence cautioni

The sequence CAI15309.1 differs from that shown. Reason: Erroneous gene model prediction. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti251 – 2533RQL → LHV in AAC50656. (PubMed:8812486)Curated
Sequence conflicti455 – 4573PAA → LV in AAC50656. (PubMed:8812486)Curated
Sequence conflicti724 – 7241I → F in AAC50656. (PubMed:8812486)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti584 – 5841H → R.
Corresponds to variant rs12121210 [ dbSNP | Ensembl ].
VAR_049362

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44060 mRNA. Translation: AAC50656.1.
AK290176 mRNA. Translation: BAF82865.1.
AL606537, AC011700 Genomic DNA. Translation: CAI15309.1. Sequence problems.
CH471100 Genomic DNA. Translation: EAW93360.1.
BC024201 mRNA. Translation: AAH24201.1.
CCDSiCCDS31021.1.
RefSeqiNP_001257545.1. NM_001270616.1.
NP_002754.2. NM_002763.4.
UniGeneiHs.741808.
Hs.744931.

Genome annotation databases

EnsembliENST00000261454; ENSP00000261454; ENSG00000117707.
ENST00000366958; ENSP00000355925; ENSG00000117707.
ENST00000435016; ENSP00000400694; ENSG00000117707.
ENST00000498508; ENSP00000420283; ENSG00000117707.
GeneIDi5629.
KEGGihsa:5629.
UCSCiuc001hkg.2. human.

Polymorphism databases

DMDMi85702224.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U44060 mRNA. Translation: AAC50656.1 .
AK290176 mRNA. Translation: BAF82865.1 .
AL606537 , AC011700 Genomic DNA. Translation: CAI15309.1 . Sequence problems.
CH471100 Genomic DNA. Translation: EAW93360.1 .
BC024201 mRNA. Translation: AAH24201.1 .
CCDSi CCDS31021.1.
RefSeqi NP_001257545.1. NM_001270616.1.
NP_002754.2. NM_002763.4.
UniGenei Hs.741808.
Hs.744931.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
2LMD NMR - A 575-737 [» ]
ProteinModelPortali Q92786.
SMRi Q92786. Positions 575-737.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 111613. 16 interactions.
IntActi Q92786. 8 interactions.
MINTi MINT-2813285.
STRINGi 9606.ENSP00000261454.

PTM databases

PhosphoSitei Q92786.

Polymorphism databases

DMDMi 85702224.

Proteomic databases

MaxQBi Q92786.
PaxDbi Q92786.
PRIDEi Q92786.

Protocols and materials databases

DNASUi 5629.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000261454 ; ENSP00000261454 ; ENSG00000117707 .
ENST00000366958 ; ENSP00000355925 ; ENSG00000117707 .
ENST00000435016 ; ENSP00000400694 ; ENSG00000117707 .
ENST00000498508 ; ENSP00000420283 ; ENSG00000117707 .
GeneIDi 5629.
KEGGi hsa:5629.
UCSCi uc001hkg.2. human.

Organism-specific databases

CTDi 5629.
GeneCardsi GC01P214156.
HGNCi HGNC:9459. PROX1.
MIMi 601546. gene.
neXtProti NX_Q92786.
PharmGKBi PA33812.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG323972.
GeneTreei ENSGT00530000063507.
HOGENOMi HOG000115708.
HOVERGENi HBG053693.
InParanoidi Q92786.
OMAi QECLSPF.
OrthoDBi EOG7MSMNK.
PhylomeDBi Q92786.
TreeFami TF316638.

Miscellaneous databases

ChiTaRSi PROX1. human.
GeneWikii PROX1.
GenomeRNAii 5629.
NextBioi 21878.
PROi Q92786.
SOURCEi Search...

Gene expression databases

Bgeei Q92786.
CleanExi HS_PROX1.
ExpressionAtlasi Q92786. baseline and differential.
Genevestigatori Q92786.

Family and domain databases

Gene3Di 1.10.10.500. 1 hit.
InterProi IPR023082. Homeo_prospero_dom.
IPR009057. Homeodomain-like.
IPR007738. Prox1.
[Graphical view ]
PANTHERi PTHR12198. PTHR12198. 1 hit.
Pfami PF05044. HPD. 1 hit.
[Graphical view ]
SUPFAMi SSF46689. SSF46689. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Structure and chromosomal localization of the human homeobox gene Prox 1."
    Zinovieva R.D., Duncan M.K., Johnson T.R., Torres R., Polymeropoulos M.H., Tomarev S.I.
    Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Tissue: Embryonic brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  3. "The DNA sequence and biological annotation of human chromosome 1."
    Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
    , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
    Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Muscle.
  6. "Transcription factor PROX1: its role in development and cancer."
    Elsir T., Smits A., Lindstroem M.S., Nister M.
    Cancer Metastasis Rev. 31:793-805(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: REVIEW.
  7. "Prospero-related homeobox 1 (Prox1) functions as a novel modulator of retinoic acid-related orphan receptors alpha- and gamma-mediated transactivation."
    Takeda Y., Jetten A.M.
    Nucleic Acids Res. 41:6992-7008(2013) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  8. "Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples."
    Lange O.F., Rossi P., Sgourakis N.G., Song Y., Lee H.W., Aramini J.M., Ertekin A., Xiao R., Acton T.B., Montelione G.T., Baker D.
    Proc. Natl. Acad. Sci. U.S.A. 109:10873-10878(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: STRUCTURE BY NMR OF 575-737.

Entry informationi

Entry nameiPROX1_HUMAN
AccessioniPrimary (citable) accession number: Q92786
Secondary accession number(s): A6NK29
, A8K2B1, Q5SW76, Q8TB91
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: September 13, 2005
Last modified: November 26, 2014
This is version 126 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3