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Q92786

- PROX1_HUMAN

UniProt

Q92786 - PROX1_HUMAN

Protein

Prospero homeobox protein 1

Gene

PROX1

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 124 (01 Oct 2014)
      Sequence version 2 (13 Sep 2005)
      Previous versions | rss
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    Functioni

    May play a fundamental role in early development of CNS. May regulate gene expression and development of postmitotic undifferentiated young neurons By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi573 – 63563Prospero-type homeoboxAdd
    BLAST

    GO - Molecular functioni

    1. DBD domain binding Source: BHF-UCL
    2. DNA binding Source: BHF-UCL
    3. LBD domain binding Source: BHF-UCL
    4. ligand-dependent nuclear receptor binding Source: BHF-UCL
    5. protein binding Source: IntAct
    6. RNA polymerase II distal enhancer sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    7. sequence-specific DNA binding Source: Ensembl
    8. sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    9. transcription corepressor activity Source: BHF-UCL
    10. transcription regulatory region DNA binding Source: BHF-UCL

    GO - Biological processi

    1. aorta smooth muscle tissue morphogenesis Source: BHF-UCL
    2. atrial cardiac muscle tissue morphogenesis Source: BHF-UCL
    3. brain development Source: BHF-UCL
    4. cell fate determination Source: Ensembl
    5. cerebellar granule cell differentiation Source: BHF-UCL
    6. dentate gyrus development Source: BHF-UCL
    7. dorsal spinal cord development Source: BHF-UCL
    8. embryonic retina morphogenesis in camera-type eye Source: BHF-UCL
    9. endocardium formation Source: BHF-UCL
    10. hepatocyte cell migration Source: Ensembl
    11. hepatocyte differentiation Source: BHF-UCL
    12. hepatocyte proliferation Source: Ensembl
    13. kidney development Source: BHF-UCL
    14. lens development in camera-type eye Source: BHF-UCL
    15. lens fiber cell morphogenesis Source: BHF-UCL
    16. liver development Source: BHF-UCL
    17. lung development Source: BHF-UCL
    18. lymphangiogenesis Source: BHF-UCL
    19. lymphatic endothelial cell differentiation Source: BHF-UCL
    20. negative regulation of bile acid biosynthetic process Source: BHF-UCL
    21. negative regulation of cell proliferation Source: BHF-UCL
    22. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    23. negative regulation of transcription, DNA-templated Source: BHF-UCL
    24. negative regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
    25. negative regulation of viral genome replication Source: BHF-UCL
    26. neural tube development Source: BHF-UCL
    27. neuronal stem cell maintenance Source: BHF-UCL
    28. olfactory placode formation Source: BHF-UCL
    29. optic placode formation involved in camera-type eye formation Source: BHF-UCL
    30. otic placode formation Source: BHF-UCL
    31. pancreas development Source: BHF-UCL
    32. positive regulation of cell cycle Source: BHF-UCL
    33. positive regulation of cell cycle checkpoint Source: Ensembl
    34. positive regulation of cell proliferation Source: BHF-UCL
    35. positive regulation of cyclin-dependent protein serine/threonine kinase activity Source: BHF-UCL
    36. positive regulation of endothelial cell migration Source: BHF-UCL
    37. positive regulation of endothelial cell proliferation Source: BHF-UCL
    38. positive regulation of forebrain neuron differentiation Source: BHF-UCL
    39. positive regulation of heart growth Source: BHF-UCL
    40. positive regulation of neural precursor cell proliferation Source: BHF-UCL
    41. positive regulation of sarcomere organization Source: BHF-UCL
    42. positive regulation of transcription, DNA-templated Source: BHF-UCL
    43. positive regulation of transcription from RNA polymerase II promoter Source: Ensembl
    44. regulation of gene expression Source: BHF-UCL
    45. regulation of transcription involved in lymphatic endothelial cell fate commitment Source: BHF-UCL
    46. response to nutrient levels Source: Ensembl
    47. retina morphogenesis in camera-type eye Source: BHF-UCL
    48. skeletal muscle thin filament assembly Source: BHF-UCL
    49. venous blood vessel morphogenesis Source: BHF-UCL
    50. ventricular cardiac muscle tissue morphogenesis Source: BHF-UCL
    51. ventricular cardiac myofibril assembly Source: BHF-UCL
    52. ventricular septum morphogenesis Source: BHF-UCL

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Prospero homeobox protein 1
    Alternative name(s):
    Homeobox prospero-like protein PROX1
    Short name:
    PROX-1
    Gene namesi
    Name:PROX1
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 1

    Organism-specific databases

    HGNCiHGNC:9459. PROX1.

    Subcellular locationi

    Nucleus Curated

    GO - Cellular componenti

    1. cytoplasm Source: BHF-UCL
    2. nucleus Source: BHF-UCL

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA33812.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 737737Prospero homeobox protein 1PRO_0000208880Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei179 – 1791PhosphoserineBy similarity
    Modified residuei511 – 5111PhosphoserineBy similarity
    Modified residuei514 – 5141PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92786.
    PaxDbiQ92786.
    PRIDEiQ92786.

    PTM databases

    PhosphoSiteiQ92786.

    Expressioni

    Tissue specificityi

    Most actively expressed in the developing lens. Detected also in embryonic brain, lung, liver and kidney. In adult, it is more abundant in heart and liver than in brain, skeletal muscle, kidney and pancreas.

    Gene expression databases

    ArrayExpressiQ92786.
    BgeeiQ92786.
    CleanExiHS_PROX1.
    GenevestigatoriQ92786.

    Interactioni

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    CTBP2P565452EBI-3912635,EBI-741533
    HNF1AP208233EBI-3912635,EBI-636034

    Protein-protein interaction databases

    BioGridi111613. 16 interactions.
    IntActiQ92786. 7 interactions.
    MINTiMINT-2813285.
    STRINGi9606.ENSP00000261454.

    Structurei

    Secondary structure

    1
    737
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi582 – 59211
    Helixi599 – 6068
    Helixi614 – 64532
    Helixi650 – 6523
    Beta strandi653 – 6564
    Helixi660 – 66910
    Helixi679 – 69820
    Helixi705 – 71511
    Helixi728 – 7303
    Helixi732 – 7343

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2LMDNMR-A575-737[»]
    ProteinModelPortaliQ92786.
    SMRiQ92786. Positions 575-737.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni636 – 737102Prospero-likeAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi215 – 2195Poly-Gln

    Sequence similaritiesi

    Belongs to the Prospero homeobox family.Curated

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG323972.
    HOGENOMiHOG000115708.
    HOVERGENiHBG053693.
    OMAiQECLSPF.
    OrthoDBiEOG7MSMNK.
    PhylomeDBiQ92786.
    TreeFamiTF316638.

    Family and domain databases

    Gene3Di1.10.10.500. 1 hit.
    InterProiIPR023082. Homeo_prospero_dom.
    IPR009057. Homeodomain-like.
    IPR007738. Prox1.
    [Graphical view]
    PANTHERiPTHR12198. PTHR12198. 1 hit.
    PfamiPF05044. HPD. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92786-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPDHDSTALL SRQTKRRRVD IGVKRTVGTA SAFFAKARAT FFSAMNPQGS    50
    EQDVEYSVVQ HADGEKSNVL RKLLKRANSY EDAMMPFPGA TIISQLLKNN 100
    MNKNGGTEPS FQASGLSSTG SEVHQEDICS NSSRDSPPEC LSPFGRPTMS 150
    QFDMDRLCDE HLRAKRARVE NIIRGMSHSP SVALRGNENE REMAPQSVSP 200
    RESYRENKRK QKLPQQQQQS FQQLVSARKE QKREERRQLK QQLEDMQKQL 250
    RQLQEKFYQI YDSTDSENDE DGNLSEDSMR SEILDARAQD SVGRSDNEMC 300
    ELDPGQFIDR ARALIREQEM AENKPKREGN NKERDHGPNS LQPEGKHLAE 350
    TLKQELNTAM SQVVDTVVKV FSAKPSRQVP QVFPPLQIPQ ARFAVNGENH 400
    NFHTANQRLQ CFGDVIIPNP LDTFGNVQMA SSTDQTEALP LVVRKNSSDQ 450
    SASGPAAGGH HQPLHQSPLS ATTGFTTSTF RHPFPLPLMA YPFQSPLGAP 500
    SGSFSGKDRA SPESLDLTRD TTSLRTKMSS HHLSHHPCSP AHPPSTAEGL 550
    SLSLIKSECG DLQDMSEISP YSGSAMQEGL SPNHLKKAKL MFFYTRYPSS 600
    NMLKTYFSDV KFNRCITSQL IKWFSNFREF YYIQMEKYAR QAINDGVTST 650
    EELSITRDCE LYRALNMHYN KANDFEVPER FLEVAQITLR EFFNAIIAGK 700
    DVDPSWKKAI YKVICKLDSE VPEIFKSPNC LQELLHE 737
    Length:737
    Mass (Da):83,203
    Last modified:September 13, 2005 - v2
    Checksum:iD243CEB421B313CA
    GO

    Sequence cautioni

    The sequence CAI15309.1 differs from that shown. Reason: Erroneous gene model prediction.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti251 – 2533RQL → LHV in AAC50656. (PubMed:8812486)Curated
    Sequence conflicti455 – 4573PAA → LV in AAC50656. (PubMed:8812486)Curated
    Sequence conflicti724 – 7241I → F in AAC50656. (PubMed:8812486)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti584 – 5841H → R.
    Corresponds to variant rs12121210 [ dbSNP | Ensembl ].
    VAR_049362

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44060 mRNA. Translation: AAC50656.1.
    AK290176 mRNA. Translation: BAF82865.1.
    AL606537, AC011700 Genomic DNA. Translation: CAI15309.1. Sequence problems.
    CH471100 Genomic DNA. Translation: EAW93360.1.
    BC024201 mRNA. Translation: AAH24201.1.
    CCDSiCCDS31021.1.
    RefSeqiNP_001257545.1. NM_001270616.1.
    NP_002754.2. NM_002763.4.
    UniGeneiHs.741808.
    Hs.744931.

    Genome annotation databases

    EnsembliENST00000261454; ENSP00000261454; ENSG00000117707.
    ENST00000366958; ENSP00000355925; ENSG00000117707.
    ENST00000435016; ENSP00000400694; ENSG00000117707.
    ENST00000498508; ENSP00000420283; ENSG00000117707.
    GeneIDi5629.
    KEGGihsa:5629.
    UCSCiuc001hkg.2. human.

    Polymorphism databases

    DMDMi85702224.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U44060 mRNA. Translation: AAC50656.1 .
    AK290176 mRNA. Translation: BAF82865.1 .
    AL606537 , AC011700 Genomic DNA. Translation: CAI15309.1 . Sequence problems.
    CH471100 Genomic DNA. Translation: EAW93360.1 .
    BC024201 mRNA. Translation: AAH24201.1 .
    CCDSi CCDS31021.1.
    RefSeqi NP_001257545.1. NM_001270616.1.
    NP_002754.2. NM_002763.4.
    UniGenei Hs.741808.
    Hs.744931.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2LMD NMR - A 575-737 [» ]
    ProteinModelPortali Q92786.
    SMRi Q92786. Positions 575-737.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111613. 16 interactions.
    IntActi Q92786. 7 interactions.
    MINTi MINT-2813285.
    STRINGi 9606.ENSP00000261454.

    PTM databases

    PhosphoSitei Q92786.

    Polymorphism databases

    DMDMi 85702224.

    Proteomic databases

    MaxQBi Q92786.
    PaxDbi Q92786.
    PRIDEi Q92786.

    Protocols and materials databases

    DNASUi 5629.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000261454 ; ENSP00000261454 ; ENSG00000117707 .
    ENST00000366958 ; ENSP00000355925 ; ENSG00000117707 .
    ENST00000435016 ; ENSP00000400694 ; ENSG00000117707 .
    ENST00000498508 ; ENSP00000420283 ; ENSG00000117707 .
    GeneIDi 5629.
    KEGGi hsa:5629.
    UCSCi uc001hkg.2. human.

    Organism-specific databases

    CTDi 5629.
    GeneCardsi GC01P214156.
    HGNCi HGNC:9459. PROX1.
    MIMi 601546. gene.
    neXtProti NX_Q92786.
    PharmGKBi PA33812.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG323972.
    HOGENOMi HOG000115708.
    HOVERGENi HBG053693.
    OMAi QECLSPF.
    OrthoDBi EOG7MSMNK.
    PhylomeDBi Q92786.
    TreeFami TF316638.

    Miscellaneous databases

    GeneWikii PROX1.
    GenomeRNAii 5629.
    NextBioi 21878.
    PROi Q92786.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92786.
    Bgeei Q92786.
    CleanExi HS_PROX1.
    Genevestigatori Q92786.

    Family and domain databases

    Gene3Di 1.10.10.500. 1 hit.
    InterProi IPR023082. Homeo_prospero_dom.
    IPR009057. Homeodomain-like.
    IPR007738. Prox1.
    [Graphical view ]
    PANTHERi PTHR12198. PTHR12198. 1 hit.
    Pfami PF05044. HPD. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Structure and chromosomal localization of the human homeobox gene Prox 1."
      Zinovieva R.D., Duncan M.K., Johnson T.R., Torres R., Polymeropoulos M.H., Tomarev S.I.
      Genomics 35:517-522(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Embryonic brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    3. "The DNA sequence and biological annotation of human chromosome 1."
      Gregory S.G., Barlow K.F., McLay K.E., Kaul R., Swarbreck D., Dunham A., Scott C.E., Howe K.L., Woodfine K., Spencer C.C.A., Jones M.C., Gillson C., Searle S., Zhou Y., Kokocinski F., McDonald L., Evans R., Phillips K.
      , Atkinson A., Cooper R., Jones C., Hall R.E., Andrews T.D., Lloyd C., Ainscough R., Almeida J.P., Ambrose K.D., Anderson F., Andrew R.W., Ashwell R.I.S., Aubin K., Babbage A.K., Bagguley C.L., Bailey J., Beasley H., Bethel G., Bird C.P., Bray-Allen S., Brown J.Y., Brown A.J., Buckley D., Burton J., Bye J., Carder C., Chapman J.C., Clark S.Y., Clarke G., Clee C., Cobley V., Collier R.E., Corby N., Coville G.J., Davies J., Deadman R., Dunn M., Earthrowl M., Ellington A.G., Errington H., Frankish A., Frankland J., French L., Garner P., Garnett J., Gay L., Ghori M.R.J., Gibson R., Gilby L.M., Gillett W., Glithero R.J., Grafham D.V., Griffiths C., Griffiths-Jones S., Grocock R., Hammond S., Harrison E.S.I., Hart E., Haugen E., Heath P.D., Holmes S., Holt K., Howden P.J., Hunt A.R., Hunt S.E., Hunter G., Isherwood J., James R., Johnson C., Johnson D., Joy A., Kay M., Kershaw J.K., Kibukawa M., Kimberley A.M., King A., Knights A.J., Lad H., Laird G., Lawlor S., Leongamornlert D.A., Lloyd D.M., Loveland J., Lovell J., Lush M.J., Lyne R., Martin S., Mashreghi-Mohammadi M., Matthews L., Matthews N.S.W., McLaren S., Milne S., Mistry S., Moore M.J.F., Nickerson T., O'Dell C.N., Oliver K., Palmeiri A., Palmer S.A., Parker A., Patel D., Pearce A.V., Peck A.I., Pelan S., Phelps K., Phillimore B.J., Plumb R., Rajan J., Raymond C., Rouse G., Saenphimmachak C., Sehra H.K., Sheridan E., Shownkeen R., Sims S., Skuce C.D., Smith M., Steward C., Subramanian S., Sycamore N., Tracey A., Tromans A., Van Helmond Z., Wall M., Wallis J.M., White S., Whitehead S.L., Wilkinson J.E., Willey D.L., Williams H., Wilming L., Wray P.W., Wu Z., Coulson A., Vaudin M., Sulston J.E., Durbin R.M., Hubbard T., Wooster R., Dunham I., Carter N.P., McVean G., Ross M.T., Harrow J., Olson M.V., Beck S., Rogers J., Bentley D.R.
      Nature 441:315-321(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    5. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Muscle.
    6. "Determination of solution structures of proteins up to 40 kDa using CS-Rosetta with sparse NMR data from deuterated samples."
      Lange O.F., Rossi P., Sgourakis N.G., Song Y., Lee H.W., Aramini J.M., Ertekin A., Xiao R., Acton T.B., Montelione G.T., Baker D.
      Proc. Natl. Acad. Sci. U.S.A. 109:10873-10878(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: STRUCTURE BY NMR OF 575-737.

    Entry informationi

    Entry nameiPROX1_HUMAN
    AccessioniPrimary (citable) accession number: Q92786
    Secondary accession number(s): A6NK29
    , A8K2B1, Q5SW76, Q8TB91
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: September 13, 2005
    Last modified: October 1, 2014
    This is version 124 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 1
      Human chromosome 1: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3