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Protein

Zinc finger protein ubi-d4

Gene

DPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23224C2H2-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 33061PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 37751PHD-type 2PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • apoptotic signaling pathway Source: ProtInc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

Apoptosis, Transcription, Transcription regulation

Keywords - Ligandi

Metal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ92785.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ubi-d4
Alternative name(s):
Apoptosis response zinc finger protein
BRG1-associated factor 45D
Short name:
BAF45D
D4, zinc and double PHD fingers family 2
Protein requiem
Gene namesi
Name:DPF2
Synonyms:BAF45D, REQ, UBID4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9964. DPF2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34331.

Polymorphism and mutation databases

BioMutaiDPF2.
DMDMi2842711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedCombined sources
Chaini2 – 391390Zinc finger protein ubi-d4PRO_0000168149Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineCombined sources
Cross-linki10 – 10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki99 – 99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki107 – 107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei142 – 1421PhosphoserineCombined sources
Modified residuei172 – 1721PhosphotyrosineCombined sources
Modified residuei176 – 1761PhosphothreonineCombined sources
Modified residuei200 – 2001PhosphoserineCombined sources
Modified residuei244 – 2441PhosphoserineCombined sources
Modified residuei280 – 2801PhosphoserineCombined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92785.
MaxQBiQ92785.
PaxDbiQ92785.
PeptideAtlasiQ92785.
PRIDEiQ92785.

PTM databases

iPTMnetiQ92785.
PhosphoSiteiQ92785.

Miscellaneous databases

PMAP-CutDBQ92785.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000133884.
CleanExiHS_DPF2.
ExpressionAtlasiQ92785. baseline and differential.
GenevisibleiQ92785. HS.

Organism-specific databases

HPAiHPA020880.
HPA056786.

Interactioni

Binary interactionsi

WithEntry#Exp.IntActNotes
LDOC1O957513EBI-359932,EBI-740738
LNX1Q8TBB13EBI-359932,EBI-739832

Protein-protein interaction databases

BioGridi111909. 53 interactions.
DIPiDIP-27575N.
IntActiQ92785. 24 interactions.
MINTiMINT-1160145.
STRINGi9606.ENSP00000436901.

Structurei

Secondary structure

1
391
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Turni204 – 2063Combined sources
Turni212 – 2143Combined sources
Beta strandi217 – 2204Combined sources
Helixi221 – 23010Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IUFX-ray1.80A203-249[»]
ProteinModelPortaliQ92785.
SMRiQ92785. Positions 203-234, 271-383.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92785.

Family & Domainsi

Sequence similaritiesi

Belongs to the requiem/DPF family.Curated
Contains 1 C2H2-type zinc finger.PROSITE-ProRule annotation
Contains 2 PHD-type zinc fingers.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri209 – 23224C2H2-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri270 – 33061PHD-type 1PROSITE-ProRule annotationAdd
BLAST
Zinc fingeri327 – 37751PHD-type 2PROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1244. Eukaryota.
ENOG410YDAG. LUCA.
GeneTreeiENSGT00530000063194.
HOGENOMiHOG000217918.
HOVERGENiHBG004475.
InParanoidiQ92785.
KOiK13196.
PhylomeDBiQ92785.
TreeFamiTF318971.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR025750. Requiem/DPF_N_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF14051. Requiem_N. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92785-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ
60 70 80 90 100
SNCYIWMEKR HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP
110 120 130 140 150
DTDQTLKKEG LISQDGSSLE ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN
160 170 180 190 200
SRARKRILEP DDFLDDLDDE DYEEDTPKRR GKGKSKGKGV GSARKKLDAS
210 220 230 240 250
ILEDRDKPYA CDICGKRYKN RPGLSYHYAH SHLAEEEGED KEDSQPPTPV
260 270 280 290 300
SQRSEEQKSK KGPDGLALPN NYCDFCLGDS KINKKTGQPE ELVSCSDCGR
310 320 330 340 350
SGHPSCLQFT PVMMAAVKTY RWQCIECKCC NICGTSENDD QLLFCDDCDR
360 370 380 390
GYHMYCLTPS MSEPPEGSWS CHLCLDLLKE KASIYQNQNS S
Length:391
Mass (Da):44,155
Last modified:November 1, 1997 - v2
Checksum:i1044B4D3036075FC
GO
Isoform 2 (identifier: Q92785-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-339: Missing.

Note: No experimental confirmation available.
Show »
Length:207
Mass (Da):23,599
Checksum:i1E065955AD9B3555
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei156 – 339184Missing in isoform 2. 1 PublicationVSP_055860Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001433 mRNA. Translation: AAB81203.1.
U94585 mRNA. Translation: AAB58307.1.
BT006718 mRNA. Translation: AAP35364.1.
AY220877 Genomic DNA. Translation: AAO26041.1.
AK291944 mRNA. Translation: BAF84633.1.
AK300061 mRNA. Translation: BAG61870.1.
AP000944 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74375.1.
BC014889 mRNA. Translation: AAH14889.1.
U43920 Genomic DNA. Translation: AAC50687.1.
CCDSiCCDS8100.1. [Q92785-1]
RefSeqiNP_006259.1. NM_006268.4. [Q92785-1]
UniGeneiHs.13495.

Genome annotation databases

EnsembliENST00000415073; ENSP00000399714; ENSG00000133884. [Q92785-2]
ENST00000528416; ENSP00000436901; ENSG00000133884. [Q92785-1]
GeneIDi5977.
KEGGihsa:5977.
UCSCiuc001odm.4. human. [Q92785-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

NIEHS-SNPs

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001433 mRNA. Translation: AAB81203.1.
U94585 mRNA. Translation: AAB58307.1.
BT006718 mRNA. Translation: AAP35364.1.
AY220877 Genomic DNA. Translation: AAO26041.1.
AK291944 mRNA. Translation: BAF84633.1.
AK300061 mRNA. Translation: BAG61870.1.
AP000944 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74375.1.
BC014889 mRNA. Translation: AAH14889.1.
U43920 Genomic DNA. Translation: AAC50687.1.
CCDSiCCDS8100.1. [Q92785-1]
RefSeqiNP_006259.1. NM_006268.4. [Q92785-1]
UniGeneiHs.13495.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3IUFX-ray1.80A203-249[»]
ProteinModelPortaliQ92785.
SMRiQ92785. Positions 203-234, 271-383.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111909. 53 interactions.
DIPiDIP-27575N.
IntActiQ92785. 24 interactions.
MINTiMINT-1160145.
STRINGi9606.ENSP00000436901.

PTM databases

iPTMnetiQ92785.
PhosphoSiteiQ92785.

Polymorphism and mutation databases

BioMutaiDPF2.
DMDMi2842711.

Proteomic databases

EPDiQ92785.
MaxQBiQ92785.
PaxDbiQ92785.
PeptideAtlasiQ92785.
PRIDEiQ92785.

Protocols and materials databases

DNASUi5977.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000415073; ENSP00000399714; ENSG00000133884. [Q92785-2]
ENST00000528416; ENSP00000436901; ENSG00000133884. [Q92785-1]
GeneIDi5977.
KEGGihsa:5977.
UCSCiuc001odm.4. human. [Q92785-1]

Organism-specific databases

CTDi5977.
GeneCardsiDPF2.
HGNCiHGNC:9964. DPF2.
HPAiHPA020880.
HPA056786.
MIMi601671. gene.
neXtProtiNX_Q92785.
PharmGKBiPA34331.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1244. Eukaryota.
ENOG410YDAG. LUCA.
GeneTreeiENSGT00530000063194.
HOGENOMiHOG000217918.
HOVERGENiHBG004475.
InParanoidiQ92785.
KOiK13196.
PhylomeDBiQ92785.
TreeFamiTF318971.

Enzyme and pathway databases

SIGNORiQ92785.

Miscellaneous databases

ChiTaRSiDPF2. human.
EvolutionaryTraceiQ92785.
GeneWikiiDPF2.
GenomeRNAii5977.
PMAP-CutDBQ92785.
PROiQ92785.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000133884.
CleanExiHS_DPF2.
ExpressionAtlasiQ92785. baseline and differential.
GenevisibleiQ92785. HS.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiIPR025750. Requiem/DPF_N_dom.
IPR007087. Znf_C2H2.
IPR015880. Znf_C2H2-like.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
PfamiPF00628. PHD. 1 hit.
PF14051. Requiem_N. 1 hit.
[Graphical view]
SMARTiSM00249. PHD. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
[Graphical view]
SUPFAMiSSF57903. SSF57903. 2 hits.
PROSITEiPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiREQU_HUMAN
AccessioniPrimary (citable) accession number: Q92785
Secondary accession number(s): A8K7C9, B4DT58
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: September 7, 2016
This is version 167 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.