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Protein

Zinc finger protein ubi-d4

Gene

DPF2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be a transcription factor required for the apoptosis response following survival factor withdrawal from myeloid cells. Might also have a role in the development and maturation of lymphoid cells.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 232C2H2-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri270 – 330PHD-type 1PROSITE-ProRule annotationAdd BLAST61
Zinc fingeri327 – 377PHD-type 2PROSITE-ProRule annotationAdd BLAST51

GO - Molecular functioni

GO - Biological processi

  • apoptotic process Source: ProtInc
  • apoptotic signaling pathway Source: ProtInc
  • regulation of transcription, DNA-templated Source: UniProtKB-KW
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processApoptosis, Transcription, Transcription regulation
LigandMetal-binding, Zinc

Enzyme and pathway databases

SIGNORiQ92785.

Names & Taxonomyi

Protein namesi
Recommended name:
Zinc finger protein ubi-d4
Alternative name(s):
Apoptosis response zinc finger protein
BRG1-associated factor 45D
Short name:
BAF45D
D4, zinc and double PHD fingers family 2
Protein requiem
Gene namesi
Name:DPF2
Synonyms:BAF45D, REQ, UBID4
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:9964. DPF2.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000133884.
PharmGKBiPA34331.

Polymorphism and mutation databases

BioMutaiDPF2.
DMDMi2842711.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Initiator methionineiRemovedCombined sources
ChainiPRO_00001681492 – 391Zinc finger protein ubi-d4Add BLAST390

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei2N-acetylalanineCombined sources1
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki99Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki107Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki108Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei142PhosphoserineCombined sources1
Modified residuei172PhosphotyrosineCombined sources1
Modified residuei176PhosphothreonineCombined sources1
Cross-linki178Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Cross-linki196Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources
Modified residuei200PhosphoserineCombined sources1
Modified residuei244PhosphoserineCombined sources1
Modified residuei280PhosphoserineCombined sources1
Cross-linki281Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2)Combined sources

Keywords - PTMi

Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92785.
MaxQBiQ92785.
PaxDbiQ92785.
PeptideAtlasiQ92785.
PRIDEiQ92785.

PTM databases

iPTMnetiQ92785.
PhosphoSitePlusiQ92785.

Miscellaneous databases

PMAP-CutDBiQ92785.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiENSG00000133884.
CleanExiHS_DPF2.
ExpressionAtlasiQ92785. baseline and differential.
GenevisibleiQ92785. HS.

Organism-specific databases

HPAiHPA020880.
HPA056786.

Interactioni

Binary interactionsi

Show more details

Protein-protein interaction databases

BioGridi111909. 55 interactors.
DIPiDIP-27575N.
IntActiQ92785. 32 interactors.
MINTiMINT-1160145.
STRINGi9606.ENSP00000436901.

Structurei

Secondary structure

1391
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni204 – 206Combined sources3
Turni212 – 214Combined sources3
Beta strandi217 – 220Combined sources4
Helixi221 – 230Combined sources10
Turni274 – 276Combined sources3
Turni284 – 286Combined sources3
Turni296 – 298Combined sources3
Turni304 – 308Combined sources5
Helixi311 – 316Combined sources6
Turni317 – 321Combined sources5
Helixi325 – 327Combined sources3
Turni331 – 333Combined sources3
Helixi339 – 341Combined sources3
Beta strandi342 – 344Combined sources3
Turni346 – 348Combined sources3
Beta strandi351 – 353Combined sources3
Turni354 – 356Combined sources3
Beta strandi357 – 359Combined sources3
Helixi372 – 378Combined sources7
Helixi379 – 381Combined sources3

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
3IUFX-ray1.80A203-249[»]
5B79X-ray2.60A270-391[»]
5VDCX-ray1.60A270-391[»]
ProteinModelPortaliQ92785.
SMRiQ92785.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92785.

Family & Domainsi

Sequence similaritiesi

Belongs to the requiem/DPF family.Curated

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri209 – 232C2H2-typePROSITE-ProRule annotationAdd BLAST24
Zinc fingeri270 – 330PHD-type 1PROSITE-ProRule annotationAdd BLAST61
Zinc fingeri327 – 377PHD-type 2PROSITE-ProRule annotationAdd BLAST51

Keywords - Domaini

Repeat, Zinc-finger

Phylogenomic databases

eggNOGiKOG1244. Eukaryota.
ENOG410YDAG. LUCA.
GeneTreeiENSGT00530000063194.
HOGENOMiHOG000217918.
HOVERGENiHBG004475.
InParanoidiQ92785.
KOiK13196.
PhylomeDBiQ92785.
TreeFamiTF318971.

Family and domain databases

Gene3Di3.30.40.10. 2 hits.
InterProiView protein in InterPro
IPR025750. Requiem/DPF_N_dom.
IPR013087. Znf_C2H2_type.
IPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR013083. Znf_RING/FYVE/PHD.
PfamiView protein in Pfam
PF00628. PHD. 1 hit.
PF14051. Requiem_N. 1 hit.
SMARTiView protein in SMART
SM00249. PHD. 2 hits.
SM00355. ZnF_C2H2. 1 hit.
SUPFAMiSSF57667. SSF57667. 1 hit.
SSF57903. SSF57903. 2 hits.
PROSITEiView protein in PROSITE
PS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
PS00028. ZINC_FINGER_C2H2_1. 1 hit.
PS50157. ZINC_FINGER_C2H2_2. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92785-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MAAVVENVVK LLGEQYYKDA MEQCHNYNAR LCAERSVRLP FLDSQTGVAQ
60 70 80 90 100
SNCYIWMEKR HRGPGLASGQ LYSYPARRWR KKRRAHPPED PRLSFPSIKP
110 120 130 140 150
DTDQTLKKEG LISQDGSSLE ALLRTDPLEK RGAPDPRVDD DSLGEFPVTN
160 170 180 190 200
SRARKRILEP DDFLDDLDDE DYEEDTPKRR GKGKSKGKGV GSARKKLDAS
210 220 230 240 250
ILEDRDKPYA CDICGKRYKN RPGLSYHYAH SHLAEEEGED KEDSQPPTPV
260 270 280 290 300
SQRSEEQKSK KGPDGLALPN NYCDFCLGDS KINKKTGQPE ELVSCSDCGR
310 320 330 340 350
SGHPSCLQFT PVMMAAVKTY RWQCIECKCC NICGTSENDD QLLFCDDCDR
360 370 380 390
GYHMYCLTPS MSEPPEGSWS CHLCLDLLKE KASIYQNQNS S
Length:391
Mass (Da):44,155
Last modified:November 1, 1997 - v2
Checksum:i1044B4D3036075FC
GO
Isoform 2 (identifier: Q92785-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     156-339: Missing.

Note: No experimental confirmation available.
Show »
Length:207
Mass (Da):23,599
Checksum:i1E065955AD9B3555
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_055860156 – 339Missing in isoform 2. 1 PublicationAdd BLAST184

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF001433 mRNA. Translation: AAB81203.1.
U94585 mRNA. Translation: AAB58307.1.
BT006718 mRNA. Translation: AAP35364.1.
AY220877 Genomic DNA. Translation: AAO26041.1.
AK291944 mRNA. Translation: BAF84633.1.
AK300061 mRNA. Translation: BAG61870.1.
AP000944 Genomic DNA. No translation available.
CH471076 Genomic DNA. Translation: EAW74375.1.
BC014889 mRNA. Translation: AAH14889.1.
U43920 Genomic DNA. Translation: AAC50687.1.
CCDSiCCDS8100.1. [Q92785-1]
RefSeqiNP_006259.1. NM_006268.4. [Q92785-1]
UniGeneiHs.13495.
Hs.633609.

Genome annotation databases

EnsembliENST00000415073; ENSP00000399714; ENSG00000133884. [Q92785-2]
ENST00000528416; ENSP00000436901; ENSG00000133884. [Q92785-1]
GeneIDi5977.
KEGGihsa:5977.
UCSCiuc001odm.4. human. [Q92785-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiREQU_HUMAN
AccessioniPrimary (citable) accession number: Q92785
Secondary accession number(s): A8K7C9, B4DT58
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 1, 1997
Last modified: August 30, 2017
This is version 176 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  4. SIMILARITY comments
    Index of protein domains and families