ID   DPF1_HUMAN              Reviewed;         380 AA.
AC   Q92782; B3KSY8; Q08AJ0;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   30-NOV-2010, sequence version 2.
DT   25-JAN-2012, entry version 94.
DE   RecName: Full=Zinc finger protein neuro-d4;
DE   AltName: Full=BRG1-associated factor 45B;
DE            Short=BAF45B;
DE   AltName: Full=D4, zinc and double PHD fingers family 1;
GN   Name=DPF1; Synonyms=BAF45B, NEUD4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), AND NUCLEOTIDE
RP   SEQUENCE [LARGE SCALE MRNA] OF 1-184 (ISOFORM 1).
RC   TISSUE=Amygdala, and Cerebellum;
RX   PubMed=14702039; DOI=10.1038/ng1285;
RA   Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R.,
RA   Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H.,
RA   Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.,
RA   Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K.,
RA   Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A.,
RA   Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M.,
RA   Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y.,
RA   Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M.,
RA   Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K.,
RA   Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S.,
RA   Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J.,
RA   Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y.,
RA   Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N.,
RA   Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S.,
RA   Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S.,
RA   Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O.,
RA   Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H.,
RA   Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B.,
RA   Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y.,
RA   Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T.,
RA   Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y.,
RA   Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S.,
RA   Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T.,
RA   Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M.,
RA   Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T.,
RA   Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K.,
RA   Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R.,
RA   Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.;
RT   "Complete sequencing and characterization of 21,243 full-length human
RT   cDNAs.";
RL   Nat. Genet. 36:40-45(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RX   PubMed=15057824; DOI=10.1038/nature02399;
RA   Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J.,
RA   Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M.,
RA   Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E.,
RA   Caenepeel S., Carrano A.V., Caoile C., Chan Y.M., Christensen M.,
RA   Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C.,
RA   Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M.,
RA   Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T.,
RA   Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H.,
RA   Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S.,
RA   Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J.,
RA   Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M.,
RA   Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J.,
RA   Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D.,
RA   Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A.,
RA   Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I.,
RA   Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E.,
RA   Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M.,
RA   Rubin E.M., Lucas S.M.;
RT   "The DNA sequence and biology of human chromosome 19.";
RL   Nature 428:529-535(2004).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L.,
RA   Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R.,
RA   Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V.,
RA   Hannenhalli S., Turner R., Yooseph S., Lu F., Nusskern D.R.,
RA   Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H.,
RA   Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G.,
RA   Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W.,
RA   Venter J.C.;
RL   Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-380 (ISOFORM 2).
RX   PubMed=15489334; DOI=10.1101/gr.2596504;
RG   The MGC Project Team;
RT   "The status, quality, and expansion of the NIH full-length cDNA
RT   project: the Mammalian Gene Collection (MGC).";
RL   Genome Res. 14:2121-2127(2004).
RN   [5]
RP   NUCLEOTIDE SEQUENCE [MRNA] OF 26-380 (ISOFORM 1).
RC   TISSUE=Brain;
RX   MEDLINE=96411662; PubMed=8812431; DOI=10.1006/geno.1996.0440;
RA   Chestkov A.V., Baka I.D., Kost M.V., Georgiev G.P., Buchman V.L.;
RT   "The d4 gene family in the human genome.";
RL   Genomics 36:174-177(1996).
CC   -!- FUNCTION: May have an important role in developing neurons by
CC       participating in regulation of cell survival, possibly as a
CC       neurospecific transcription factor. Belongs to the neuron-specific
CC       chromatin remodeling complex (nBAF complex). During neural
CC       development a switch from a stem/progenitor to a post-mitotic
CC       chromatin remodeling mechanism occurs as neurons exit the cell
CC       cycle and become committed to their adult state. The transition
CC       from proliferating neural stem/progenitor cells to post-mitotic
CC       neurons requires a switch in subunit composition of the npBAF and
CC       nBAF complexes. As neural progenitors exit mitosis and
CC       differentiate into neurons, npBAF complexes which contain
CC       ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous
CC       alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits
CC       in neuron-specific complexes (nBAF). The npBAF complex is
CC       essential for the self-renewal/proliferative capacity of the
CC       multipotent neural stem cells. The nBAF complex along with CREST
CC       plays a role regulating the activity of genes essential for
CC       dendrite growth (By similarity).
CC   -!- SUBUNIT: Component of neuron-specific chromatin remodeling complex
CC       (nBAF complex) composed of at least, ARID1A/BAF250A or
CC       ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C,
CC       SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47,
CC       SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B,
CC       DPF3/BAF45C, ACTL6B/BAF53B and actin (By similarity).
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential). Nucleus (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=3;
CC         Comment=Additional isoforms seem to exist;
CC       Name=1;
CC         IsoId=Q92782-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q92782-2; Sequence=VSP_040225, VSP_040226;
CC       Name=3;
CC         IsoId=Q92782-3; Sequence=VSP_040224, VSP_040225, VSP_040226;
CC   -!- SIMILARITY: Belongs to the requiem/DPF family.
CC   -!- SIMILARITY: Contains 2 PHD-type zinc fingers.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-28 is the initiator.
CC   -!- SEQUENCE CAUTION:
CC       Sequence=AAC50685.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=AAI25154.1; Type=Erroneous initiation; Note=Translation N-terminally extended;
CC       Sequence=EAW56763.1; Type=Erroneous gene model prediction;
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AK094632; BAG52900.1; -; mRNA.
DR   EMBL; DA076421; -; NOT_ANNOTATED_CDS; mRNA.
DR   EMBL; AC011479; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH471126; EAW56763.1; ALT_SEQ; Genomic_DNA.
DR   EMBL; BC125153; AAI25154.1; ALT_INIT; mRNA.
DR   EMBL; U43843; AAC50685.1; ALT_INIT; mRNA.
DR   IPI; IPI00216452; -.
DR   IPI; IPI00291761; -.
DR   IPI; IPI00642063; -.
DR   RefSeq; NP_001128627.1; NM_001135155.1.
DR   RefSeq; NP_001128628.1; NM_001135156.1.
DR   RefSeq; NP_004638.2; NM_004647.2.
DR   UniGene; Hs.631576; -.
DR   ProteinModelPortal; Q92782; -.
DR   SMR; Q92782; 256-374.
DR   IntAct; Q92782; 1.
DR   MINT; MINT-4302537; -.
DR   STRING; Q92782; -.
DR   PhosphoSite; Q92782; -.
DR   DMDM; 2500145; -.
DR   PRIDE; Q92782; -.
DR   Ensembl; ENST00000355526; ENSP00000347716; ENSG00000011332.
DR   Ensembl; ENST00000412732; ENSP00000412098; ENSG00000011332.
DR   Ensembl; ENST00000414789; ENSP00000391884; ENSG00000011332.
DR   Ensembl; ENST00000420980; ENSP00000397354; ENSG00000011332.
DR   Ensembl; ENST00000434076; ENSP00000413691; ENSG00000011332.
DR   Ensembl; ENST00000437720; ENSP00000394981; ENSG00000011332.
DR   Ensembl; ENST00000444314; ENSP00000400336; ENSG00000011332.
DR   Ensembl; ENST00000456296; ENSP00000411569; ENSG00000011332.
DR   GeneID; 8193; -.
DR   KEGG; hsa:8193; -.
DR   UCSC; uc002ohl.1; human.
DR   CTD; 8193; -.
DR   GeneCards; GC19M038701; -.
DR   HGNC; HGNC:20225; DPF1.
DR   MIM; 601670; gene.
DR   neXtProt; NX_Q92782; -.
DR   PharmGKB; PA134879894; -.
DR   GeneTree; ENSGT00530000063194; -.
DR   HOVERGEN; HBG004475; -.
DR   InParanoid; Q92782; -.
DR   OMA; CEYKIDC; -.
DR   OrthoDB; EOG4T4CX1; -.
DR   NextBio; 30890; -.
DR   ArrayExpress; Q92782; -.
DR   Bgee; Q92782; -.
DR   CleanEx; HS_DPF1; -.
DR   Genevestigator; Q92782; -.
DR   GermOnline; ENSG00000011332; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0071565; C:nBAF complex; ISS:UniProtKB.
DR   GO; GO:0008270; F:zinc ion binding; IEA:InterPro.
DR   GO; GO:0006917; P:induction of apoptosis; TAS:ProtInc.
DR   GO; GO:0007399; P:nervous system development; ISS:UniProtKB.
DR   GO; GO:0006355; P:regulation of transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   GO; GO:0006351; P:transcription, DNA-dependent; IEA:UniProtKB-KW.
DR   InterPro; IPR011011; Znf_FYVE_PHD.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   InterPro; IPR013083; Znf_RING/FYVE/PHD.
DR   Gene3D; G3DSA:3.30.40.10; Znf_RING/FYVE/PHD; 2.
DR   Pfam; PF00628; PHD; 1.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00184; RING; 2.
DR   SUPFAM; SSF57903; FYVE_PHD_ZnF; 1.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytoplasm; Metal-binding;
KW   Neurogenesis; Nucleus; Reference proteome; Repeat; Transcription;
KW   Transcription regulation; Zinc; Zinc-finger.
FT   CHAIN         1    380       Zinc finger protein neuro-d4.
FT                                /FTId=PRO_0000168145.
FT   ZN_FING     254    311       PHD-type 1.
FT   ZN_FING     308    368       PHD-type 2.
FT   VAR_SEQ       1     82       Missing (in isoform 3).
FT                                /FTId=VSP_040224.
FT   VAR_SEQ     226    226       K -> ICGKRYKNRPGLSYHYTHTHLAEEEGEENAERHALP
FT                                FHRKNNHKQ (in isoform 2 and isoform 3).
FT                                /FTId=VSP_040225.
FT   VAR_SEQ     321    330       Missing (in isoform 2 and isoform 3).
FT                                /FTId=VSP_040226.
FT   CONFLICT     25     25       G -> T (in Ref. 4; AAI25154).
FT   CONFLICT     34     34       G -> S (in Ref. 5; AAC50685).
SQ   SEQUENCE   380 AA;  42502 MW;  C3550A83807B4FDB CRC64;
     MGGLSARPTA GRTDPAGTCW GQDPGSKMAT VIPGPLSLGE DFYREAIEHC RSYNARLCAE
     RSLRLPFLDS QTGVAQNNCY IWMEKTHRGP GLAPGQIYTY PARCWRKKRR LNILEDPRLR
     PCEYKIDCEA PLKKEGGLPE GPVLEALLCA ETGEKKIELK EEETIMDCQK QQLLEFPHDL
     EVEDLEDDIP RRKNRAKGKA YGIGGLRKRQ DTASLEDRDK PYVCDKFYKE LAWVPEAQRK
     HTAKKAPDGT VIPNGYCDFC LGGSKKTGCP EDLISCADCG RSGHPSCLQF TVNMTAAVRT
     YRWQCIECKS CSLCGTSEND GASWAGLTPQ DQLLFCDDCD RGYHMYCLSP PMAEPPEGSW
     SCHLCLRHLK EKASAYITLT
//