ID   DPF1_HUMAN              Reviewed;         353 AA.
AC   Q92782;
DT   01-NOV-1997, integrated into UniProtKB/Swiss-Prot.
DT   01-FEB-1997, sequence version 1.
DT   13-OCT-2009, entry version 74.
DE   RecName: Full=Zinc finger protein neuro-d4;
DE   AltName: Full=D4, zinc and double PHD fingers family 1;
GN   Name=DPF1; Synonyms=NEUD4;
OS   Homo sapiens (Human).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini;
OC   Catarrhini; Hominidae; Homo.
OX   NCBI_TaxID=9606;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2).
RC   TISSUE=Brain;
RX   MEDLINE=96411662; PubMed=8812431; DOI=10.1006/geno.1996.0440;
RA   Chestkov A.V., Baka I.D., Kost M.V., Georgiev G.P., Buchman V.L.;
RT   "The d4 gene family in the human genome.";
RL   Genomics 36:174-177(1996).
CC   -!- FUNCTION: May have an important role in developing neurons by
CC       participating in regulation of cell survival, possibly as a
CC       neurospecific transcription factor.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (Potential). Nucleus (Potential).
CC   -!- ALTERNATIVE PRODUCTS:
CC       Event=Alternative splicing; Named isoforms=2;
CC         Comment=Additional isoforms seem to exist;
CC       Name=1;
CC         IsoId=Q92782-1; Sequence=Displayed;
CC       Name=2;
CC         IsoId=Q92782-2; Sequence=VSP_005607;
CC   -!- SIMILARITY: Belongs to the requiem/DPF family.
CC   -!- SIMILARITY: Contains 2 PHD-type zinc fingers.
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DR   EMBL; U43843; AAC50685.1; -; mRNA.
DR   IPI; IPI00216452; -.
DR   IPI; IPI00291761; -.
DR   RefSeq; NP_001128628.1; -.
DR   RefSeq; NP_004638.2; -.
DR   UniGene; Hs.631576; -.
DR   HSSP; Q14839; 1MM2.
DR   IntAct; Q92782; 1.
DR   STRING; Q92782; -.
DR   Ensembl; ENST00000355526; ENSP00000347716; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000412732; ENSP00000412098; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000414789; ENSP00000391884; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000416611; ENSP00000390223; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000418517; ENSP00000408201; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000420105; ENSP00000404257; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000420980; ENSP00000397354; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000434076; ENSP00000413691; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000437720; ENSP00000394981; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000438060; ENSP00000416347; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000438365; ENSP00000399015; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000444314; ENSP00000400336; ENSG00000011332; Homo sapiens.
DR   Ensembl; ENST00000456296; ENSP00000411569; ENSG00000011332; Homo sapiens.
DR   GeneID; 8193; -.
DR   UCSC; uc002ohl.1; human.
DR   CTD; 8193; -.
DR   GeneCards; GC19M043394; -.
DR   H-InvDB; HIX0015085; -.
DR   HGNC; HGNC:20225; DPF1.
DR   MIM; 601670; gene.
DR   PharmGKB; PA134879894; -.
DR   HOVERGEN; Q92782; -.
DR   NextBio; 30890; -.
DR   ArrayExpress; Q92782; -.
DR   Bgee; Q92782; -.
DR   CleanEx; HS_DPF1; -.
DR   Genevestigator; Q92782; -.
DR   GermOnline; ENSG00000011332; Homo sapiens.
DR   GO; GO:0005737; C:cytoplasm; IEA:UniProtKB-SubCell.
DR   GO; GO:0005634; C:nucleus; IEA:UniProtKB-SubCell.
DR   GO; GO:0005515; F:protein binding; IEA:InterPro.
DR   GO; GO:0008270; F:zinc ion binding; IEA:UniProtKB-KW.
DR   GO; GO:0006917; P:induction of apoptosis; TAS:ProtInc.
DR   GO; GO:0045449; P:regulation of transcription; IEA:UniProtKB-KW.
DR   GO; GO:0006350; P:transcription; IEA:UniProtKB-KW.
DR   InterPro; IPR019786; Zinc_finger_PHD-type_CS.
DR   InterPro; IPR001965; Znf_PHD.
DR   InterPro; IPR019787; Znf_PHD-finger.
DR   InterPro; IPR001841; Znf_RING.
DR   Pfam; PF00628; PHD; 2.
DR   SMART; SM00249; PHD; 2.
DR   SMART; SM00184; RING; 2.
DR   PROSITE; PS01359; ZF_PHD_1; 1.
DR   PROSITE; PS50016; ZF_PHD_2; 2.
PE   2: Evidence at transcript level;
KW   Alternative splicing; Complete proteome; Cytoplasm; Metal-binding;
KW   Nucleus; Repeat; Transcription; Transcription regulation; Zinc;
KW   Zinc-finger.
FT   CHAIN         1    353       Zinc finger protein neuro-d4.
FT                                /FTId=PRO_0000168145.
FT   ZN_FING     227    284       PHD-type 1.
FT   ZN_FING     281    341       PHD-type 2.
FT   VAR_SEQ     294    303       Missing (in isoform 2).
FT                                /FTId=VSP_005607.
SQ   SEQUENCE   353 AA;  39876 MW;  137D8310E77FB111 CRC64;
     MATVIPSPLS LGEDFYREAI EHCRSYNARL CAERSLRLPF LDSQTGVAQN NCYIWMEKTH
     RGPGLAPGQI YTYPARCWRK KRRLNILEDP RLRPCEYKID CEAPLKKEGG LPEGPVLEAL
     LCAETGEKKI ELKEEETIMD CQKQQLLEFP HDLEVEDLED DIPRRKNRAK GKAYGIGGLR
     KRQDTASLED RDKPYVCDKF YKELAWVPEA QRKHTAKKAP DGTVIPNGYC DFCLGGSKKT
     GCPEDLISCA DCGRSGHPSC LQFTVNMTAA VRTYRWQCIE CKSCSLCGTS ENDGASWAGL
     TPQDQLLFCD DCDRGYHMYC LSPPMAEPPE GSWSCHLCLR HLKEKASAYI TLT
//