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Q92782 (DPF1_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified January 25, 2012. Version 94. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Zinc finger protein neuro-d4
Alternative name(s):
BRG1-associated factor 45B
Short name=BAF45B
D4, zinc and double PHD fingers family 1
Gene names
Name:DPF1
Synonyms:BAF45B, NEUD4
OrganismHomo sapiens (Human)
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length380 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

May have an important role in developing neurons by participating in regulation of cell survival, possibly as a neurospecific transcription factor. Belongs to the neuron-specific chromatin remodeling complex (nBAF complex). During neural development a switch from a stem/progenitor to a post-mitotic chromatin remodeling mechanism occurs as neurons exit the cell cycle and become committed to their adult state. The transition from proliferating neural stem/progenitor cells to post-mitotic neurons requires a switch in subunit composition of the npBAF and nBAF complexes. As neural progenitors exit mitosis and differentiate into neurons, npBAF complexes which contain ACTL6A/BAF53A and PHF10/BAF45A, are exchanged for homologous alternative ACTL6B/BAF53B and DPF1/BAF45B or DPF3/BAF45C subunits in neuron-specific complexes (nBAF). The npBAF complex is essential for the self-renewal/proliferative capacity of the multipotent neural stem cells. The nBAF complex along with CREST plays a role regulating the activity of genes essential for dendrite growth By similarity.

Subunit structure

Component of neuron-specific chromatin remodeling complex (nBAF complex) composed of at least, ARID1A/BAF250A or ARID1B/BAF250B, SMARCD1/BAF60A, SMARCD3/BAF60C, SMARCA2/BRM/BAF190B, SMARCA4/BRG1/BAF190A, SMARCB1/BAF47, SMARCC1/BAF155, SMARCE1/BAF57, SMARCC2/BAF170, DPF1/BAF45B, DPF3/BAF45C, ACTL6B/BAF53B and actin By similarity.

Subcellular location

Cytoplasm Potential. Nucleus Potential.

Sequence similarities

Belongs to the requiem/DPF family.

Contains 2 PHD-type zinc fingers.

Caution

It is uncertain whether Met-1 or Met-28 is the initiator.

Sequence caution

The sequence AAC50685.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence AAI25154.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence EAW56763.1 differs from that shown. Reason: Erroneous gene model prediction.

Alternative products

This entry describes 3 isoforms produced by alternative splicing. [Align] [Select]

Note: Additional isoforms seem to exist.
Isoform 1 (identifier: Q92782-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q92782-2)

The sequence of this isoform differs from the canonical sequence as follows:
     226-226: K → ICGKRYKNRPGLSYHYTHTHLAEEEGEENAERHALPFHRKNNHKQ
     321-330: Missing.
Isoform 3 (identifier: Q92782-3)

The sequence of this isoform differs from the canonical sequence as follows:
     1-82: Missing.
     226-226: K → ICGKRYKNRPGLSYHYTHTHLAEEEGEENAERHALPFHRKNNHKQ
     321-330: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 380380Zinc finger protein neuro-d4
PRO_0000168145

Regions

Zinc finger254 – 31158PHD-type 1
Zinc finger308 – 36861PHD-type 2

Natural variations

Alternative sequence1 – 8282Missing in isoform 3.
VSP_040224
Alternative sequence2261K → ICGKRYKNRPGLSYHYTHTH LAEEEGEENAERHALPFHRK NNHKQ in isoform 2 and isoform 3.
VSP_040225
Alternative sequence321 – 33010Missing in isoform 2 and isoform 3.
VSP_040226

Experimental info

Sequence conflict251G → T in AAI25154. Ref.4
Sequence conflict341G → S in AAC50685. Ref.5

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified November 30, 2010. Version 2.
Checksum: C3550A83807B4FDB

FASTA38042,502
        10         20         30         40         50         60 
MGGLSARPTA GRTDPAGTCW GQDPGSKMAT VIPGPLSLGE DFYREAIEHC RSYNARLCAE 

        70         80         90        100        110        120 
RSLRLPFLDS QTGVAQNNCY IWMEKTHRGP GLAPGQIYTY PARCWRKKRR LNILEDPRLR 

       130        140        150        160        170        180 
PCEYKIDCEA PLKKEGGLPE GPVLEALLCA ETGEKKIELK EEETIMDCQK QQLLEFPHDL 

       190        200        210        220        230        240 
EVEDLEDDIP RRKNRAKGKA YGIGGLRKRQ DTASLEDRDK PYVCDKFYKE LAWVPEAQRK 

       250        260        270        280        290        300 
HTAKKAPDGT VIPNGYCDFC LGGSKKTGCP EDLISCADCG RSGHPSCLQF TVNMTAAVRT 

       310        320        330        340        350        360 
YRWQCIECKS CSLCGTSEND GASWAGLTPQ DQLLFCDDCD RGYHMYCLSP PMAEPPEGSW 

       370        380 
SCHLCLRHLK EKASAYITLT

« Hide

Isoform 2 [UniParc].

Checksum: 343C21142565D5FF
Show »

FASTA41446,785
Isoform 3 [UniParc].

Checksum: A3E86C6D5C87F240
Show »

FASTA33237,869

References

« Hide 'large scale' references
[1]"Complete sequencing and characterization of 21,243 full-length human cDNAs."
Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S. expand/collapse author list , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
Nat. Genet. 36:40-45(2004) [PubMed: 14702039] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 3), NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-184 (ISOFORM 1).
Tissue: Amygdala and Cerebellum.
[2]"The DNA sequence and biology of human chromosome 19."
Grimwood J., Gordon L.A., Olsen A.S., Terry A., Schmutz J., Lamerdin J.E., Hellsten U., Goodstein D., Couronne O., Tran-Gyamfi M., Aerts A., Altherr M., Ashworth L., Bajorek E., Black S., Branscomb E., Caenepeel S., Carrano A.V. expand/collapse author list , Caoile C., Chan Y.M., Christensen M., Cleland C.A., Copeland A., Dalin E., Dehal P., Denys M., Detter J.C., Escobar J., Flowers D., Fotopulos D., Garcia C., Georgescu A.M., Glavina T., Gomez M., Gonzales E., Groza M., Hammon N., Hawkins T., Haydu L., Ho I., Huang W., Israni S., Jett J., Kadner K., Kimball H., Kobayashi A., Larionov V., Leem S.-H., Lopez F., Lou Y., Lowry S., Malfatti S., Martinez D., McCready P.M., Medina C., Morgan J., Nelson K., Nolan M., Ovcharenko I., Pitluck S., Pollard M., Popkie A.P., Predki P., Quan G., Ramirez L., Rash S., Retterer J., Rodriguez A., Rogers S., Salamov A., Salazar A., She X., Smith D., Slezak T., Solovyev V., Thayer N., Tice H., Tsai M., Ustaszewska A., Vo N., Wagner M., Wheeler J., Wu K., Xie G., Yang J., Dubchak I., Furey T.S., DeJong P., Dickson M., Gordon D., Eichler E.E., Pennacchio L.A., Richardson P., Stubbs L., Rokhsar D.S., Myers R.M., Rubin E.M., Lucas S.M.
Nature 428:529-535(2004) [PubMed: 15057824] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. expand/collapse author list , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C.
Submitted (JUL-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 25-380 (ISOFORM 2).
[5]"The d4 gene family in the human genome."
Chestkov A.V., Baka I.D., Kost M.V., Georgiev G.P., Buchman V.L.
Genomics 36:174-177(1996) [PubMed: 8812431] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 26-380 (ISOFORM 1).
Tissue: Brain.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AK094632 mRNA. Translation: BAG52900.1.
DA076421 mRNA. No translation available.
AC011479 Genomic DNA. No translation available.
CH471126 Genomic DNA. Translation: EAW56763.1. Sequence problems.
BC125153 mRNA. Translation: AAI25154.1. Different initiation.
U43843 mRNA. Translation: AAC50685.1. Different initiation.
IPIIPI00216452.
IPI00291761.
IPI00642063.
RefSeqNP_001128627.1. NM_001135155.1.
NP_001128628.1. NM_001135156.1.
NP_004638.2. NM_004647.2.
UniGeneHs.631576.

3D structure databases

ProteinModelPortalQ92782.
SMRQ92782. Positions 256-374.
ModBaseSearch...

Protein-protein interaction databases

IntActQ92782. 1 interaction.
MINTMINT-4302537.
STRINGQ92782.

PTM databases

PhosphoSiteQ92782.

Polymorphism databases

DMDM2500145.

Proteomic databases

PRIDEQ92782.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000355526; ENSP00000347716; ENSG00000011332.
ENST00000412732; ENSP00000412098; ENSG00000011332.
ENST00000414789; ENSP00000391884; ENSG00000011332.
ENST00000420980; ENSP00000397354; ENSG00000011332.
ENST00000434076; ENSP00000413691; ENSG00000011332.
ENST00000437720; ENSP00000394981; ENSG00000011332.
ENST00000444314; ENSP00000400336; ENSG00000011332.
ENST00000456296; ENSP00000411569; ENSG00000011332.
GeneID8193.
KEGGhsa:8193.
UCSCuc002ohl.1. human.

Organism-specific databases

CTD8193.
GeneCardsGC19M038701.
HGNCHGNC:20225. DPF1.
MIM601670. gene.
neXtProtNX_Q92782.
PharmGKBPA134879894.
GenAtlasSearch...

Phylogenomic databases

GeneTreeENSGT00530000063194.
HOVERGENHBG004475.
InParanoidQ92782.
OMACEYKIDC.
OrthoDBEOG4T4CX1.

Gene expression databases

ArrayExpressQ92782.
BgeeQ92782.
CleanExHS_DPF1.
GenevestigatorQ92782.
GermOnlineENSG00000011332. Homo sapiens.

Family and domain databases

InterProIPR011011. Znf_FYVE_PHD.
IPR001965. Znf_PHD.
IPR019787. Znf_PHD-finger.
IPR001841. Znf_RING.
IPR013083. Znf_RING/FYVE/PHD.
[Graphical view]
Gene3DG3DSA:3.30.40.10. Znf_RING/FYVE/PHD. 2 hits.
PfamPF00628. PHD. 1 hit.
[Graphical view]
SMARTSM00249. PHD. 2 hits.
SM00184. RING. 2 hits.
[Graphical view]
SUPFAMSSF57903. FYVE_PHD_ZnF. 1 hit.
PROSITEPS01359. ZF_PHD_1. 1 hit.
PS50016. ZF_PHD_2. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio30890.
SOURCESearch...

Entry information

Entry nameDPF1_HUMAN
AccessionPrimary (citable) accession number: Q92782
Secondary accession number(s): B3KSY8, Q08AJ0
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: November 30, 2010
Last modified: January 25, 2012
This is version 94 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

Human chromosome 19

Human chromosome 19: entries, gene names and cross-references to MIM

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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