SYN2

Functionⁱ

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

GO - Molecular functionⁱ

ATP binding
Source: ParkinsonsUK-UCL
Traceable author statementⁱ
- 15217342
catalytic activity Source: InterPro

Complete GO annotation...

GO - Biological processⁱ

chemical synaptic transmission
Source: ProtInc
Traceable author statementⁱ
- 8964517
neurotransmitter secretion Source: ParkinsonsUK-UCL

Complete GO annotation...

Enzyme and pathway databases

Reactomeⁱ	R-HSA-181429. Serotonin Neurotransmitter Release Cycle. R-HSA-212676. Dopamine Neurotransmitter Release Cycle.
SIGNORⁱ	Q92777.

Names & Taxonomyⁱ

Protein namesⁱ	Recommended name: Synapsin-2 Alternative name(s): Synapsin II
Gene namesⁱ	Name:SYN2
Organismⁱ	Homo sapiens (Human)
Taxonomic identifierⁱ	9606 [NCBI]
Taxonomic lineageⁱ	cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo
Proteomesⁱ	UP000005640 Componentⁱ: Unplaced

Organism-specific databases

Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11495. SYN2.

HGNCⁱ

HGNC:11495. SYN2.

Keywords - Cellular componentⁱ

Cell junction, Synapse

Pathology & Biotechⁱ

Organism-specific databases

DisGeNET More...DisGeNETⁱ	6854.
MalaCards human disease database More...MalaCardsⁱ	SYN2.

Polymorphism and mutation databases

DMDMⁱ	223634710.

DMDMⁱ

223634710.

PTM / Processingⁱ

Molecule processing

Feature key	Position(s)	DescriptionActions	Graphical view	Length
ChainⁱPRO_0000183021	1 – 582	Synapsin-2Add BLAST		582

Amino acid modifications

Feature key	Position(s)	DescriptionActions	Length
Modified residueⁱ	10	Phosphoserine; by PKA and CaMK1By similarity	1
Modified residueⁱ	421	PhosphothreonineBy similarity	1
Modified residueⁱ	425	PhosphoserineBy similarity	1

Post-translational modificationⁱ

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Keywords - PTMⁱ

Phosphoprotein

Proteomic databases

EPDⁱ	Q92777.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92777.
PeptideAtlas More...PeptideAtlasⁱ	Q92777.
PRIDEⁱ	Q92777.

2D gel databases

UCD-2DPAGEⁱ	Q92777.

UCD-2DPAGEⁱ

Q92777.

PTM databases

iPTMnetⁱ	Q92777.
PhosphoSitePlusⁱ	Q92777.

Expressionⁱ

Tissue specificityⁱ

Central and peripheral nervous systems.

Gene expression databases

CleanExⁱ	HS_SYN2.

CleanExⁱ

HS_SYN2.

Organism-specific databases

Human Protein Atlas More...HPAⁱ	HPA037012.

HPAⁱ

HPA037012.

Interactionⁱ

Subunit structureⁱ

Interacts with CAPON.By similarity

Protein-protein interaction databases

BioGridⁱ	112720. 14 interactors.
CORUMⁱ	Q92777.
IntActⁱ	Q92777. 1 interactor.

Structureⁱ

3D structure databases

ProteinModelPortalⁱ	Q92777.
SMRⁱ	Q92777.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Family & Domainsⁱ

Region

Feature key	Position(s)	DescriptionActions	Length
Regionⁱ	1 – 29	AAdd BLAST	29
Regionⁱ	33 – 112	B; linkerAdd BLAST	80
Regionⁱ	113 – 420	C; actin-binding and synaptic-vesicle bindingAdd BLAST	308
Regionⁱ	421 – 457	G; Pro-rich linkerAdd BLAST	37
Regionⁱ	458 – 533	H; Pro/Ser-rich linkerAdd BLAST	76
Regionⁱ	534 – 582	EAdd BLAST	49

Compositional bias

Feature key	Position(s)	DescriptionActions	Length
Compositional biasⁱ	34 – 42	Poly-Pro	9
Compositional biasⁱ	486 – 496	Poly-SerAdd BLAST	11
Compositional biasⁱ	512 – 516	Poly-Ser	5

Domainⁱ

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesⁱ

Belongs to the synapsin family.Curated

Phylogenomic databases

HOVERGENⁱ	HBG016354.
InParanoidⁱ	Q92777.
KEGG Orthology (KO) More...KOⁱ	K19941.
PhylomeDBⁱ	Q92777.

Family and domain databases

Gene3Dⁱ	3.30.1490.20. 1 hit.
InterProⁱ	View protein in InterPro IPR013815. ATP_grasp_subdomain_1. IPR016185. PreATP-grasp_dom. IPR001359. Synapsin. IPR020898. Synapsin_ATP-bd_dom. IPR019735. Synapsin_CS. IPR019736. Synapsin_P_site. IPR020897. Synapsin_pre-ATP-grasp_dom.
PANTHERⁱ	PTHR10841. PTHR10841. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02078. Synapsin. 1 hit. PF02750. Synapsin_C. 1 hit. PF10581. Synapsin_N. 1 hit.
PRINTSⁱ	PR01368. SYNAPSIN.
SUPFAMⁱ	SSF52440. SSF52440. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00415. SYNAPSIN_1. 1 hit. PS00416. SYNAPSIN_2. 1 hit.

Sequences (2)ⁱ

Sequence statusⁱ: Complete.

This entry describes 2 isoformsⁱ produced by alternative splicing. Align Add to basket Added to basket

Isoform IIa (identifier: Q92777-1) [UniParc]FASTA Add to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA 
        60         70         80         90        100
PPTASPGPER TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV 
       110        120        130        140        150
DAPGAAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE 
       160        170        180        190        200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH 
       210        220        230        240        250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT 
       260        270        280        290        300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 
       310        320        330        340        350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS 
       360        370        380        390        400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV 
       410        420        430        440        450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP 
       460        470        480        490        500
QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR 
       510        520        530        540        550
PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS 
       560        570        580 
ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD

Length:582

Mass (Da):62,847

Last modified:February 10, 2009 - v3

Checksum:ⁱ70BB0F77CCF9B1E1

GO

Isoform IIb (identifier: Q92777-2) [UniParc]FASTA Add to basket

The sequence of this isoform differs from the canonical sequence as follows:
458-480: GPGQPQGMQPPGKVLPPRRLPPG → CLQYILDCNGIAVGPKQVQAS
481-582: Missing.

« Hide

        10         20         30         40         50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA 
        60         70         80         90        100
PPTASPGPER TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV 
       110        120        130        140        150
DAPGAAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE 
       160        170        180        190        200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH 
       210        220        230        240        250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT 
       260        270        280        290        300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 
       310        320        330        340        350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS 
       360        370        380        390        400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV 
       410        420        430        440        450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP 
       460        470 
QRPPPQGCLQ YILDCNGIAV GPKQVQAS

Show »

Length:478

Mass (Da):52,162

Checksum:ⁱ8DF5B468E0E3BF81

GO

Sequence cautionⁱ

The sequence AC022234 differs from that shown. Several in-frame stop codons.Curated

The sequence AC022234 differs from that shown. Reason: Frameshift at position 71.Curated

Experimental Info

Feature key	Position(s)	DescriptionActions	Length
Sequence conflictⁱ	34	A → P in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	34	A → P in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	34	A → P in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	36	T → P in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	36	T → P in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	36	T → P in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	61	T → K in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	61	T → K in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	61	T → R in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	64	A → P in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	64	A → P in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	64	A → P in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	70	P → A in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	71	P → Q in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	71	P → Q in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	71	P → Q in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	74	R → P in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	74	R → P in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	74	R → P in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	82	L → F in AAC50718 (PubMed:8964517).Curated	1
Sequence conflictⁱ	82	L → F in AAC28368 (PubMed:10565545).Curated	1
Sequence conflictⁱ	82	L → F in AAC33789 (PubMed:10565545).Curated	1
Sequence conflictⁱ	104 – 105	GA → AP in AAC50718 (PubMed:8964517).Curated	2
Sequence conflictⁱ	104 – 105	GA → AP in AAC28368 (PubMed:10565545).Curated	2
Sequence conflictⁱ	104 – 105	GA → AP in AAC33789 (PubMed:10565545).Curated	2

Natural variant

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Natural variantⁱVAR_059825	506	T → A. Corresponds to variant dbSNP:rs794999Ensembl.		1

Alternative sequence

Feature key	Position(s)	DescriptionActions	Graphical view	Length
Alternative sequenceⁱVSP_006320	458 – 480	GPGQP…RLPPG → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsAdd BLAST		23
Alternative sequenceⁱVSP_006321	481 – 582	Missing in isoform IIb. 2 PublicationsAdd BLAST		102

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40215 mRNA. Translation: AAC50718.1. AF077671 mRNA. Translation: AAC28368.1. AF077737 mRNA. Translation: AAC33789.1. AC022234 Genomic DNA. No translation available. AC026166 Genomic DNA. No translation available. AC091492 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74900.1. [Q92777-1] CCDS74901.1. [Q92777-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_003169.2. NM_003178.5.
UniGeneⁱ	Hs.445503.

Genome annotation databases

GeneIDⁱ	6854.
KEGGⁱ	hsa:6854.

Keywords - Coding sequence diversityⁱ

Alternative splicing, Polymorphism

Similar proteinsⁱ

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q92777	B3KRB3 A0A024R2F6 UPI0003EAF447	Homo sapiens (Human)	582	UniRef100_Q92777	Cluster: Synapsin-2	4

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q92777	Q63537 UPI000A308696 UPI00093CF7EB UPI0005FAFFAC UPI00072F90C3 UPI0007870095 UPI000846FED1 Q64332 UPI00001ADE0A G3V733 +44	Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Hipposideros armiger (great roundleaf bat) Ovis aries musimon (Mouflon) Ovis aries (Sheep) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Capra hircus (Goat) Mus musculus (Mouse) Mus caroli (Ryukyu mouse) (Ricefield mouse) Aotus nancymaae (Ma's night monkey) And more	586	UniRef90_Q63537	Cluster: Synapsin-2	55
Q92777-2	UPI0007629588 F7E5S8 UPI0003F0AF08 B4DI62 I7GBE8 Q59GM1 UPI0000EE2948	Marmota marmota marmota (Alpine marmot) Callithrix jacchus (White-tufted-ear marmoset) Elephantulus edwardii (Cape long-eared elephant shrew) Homo sapiens (Human) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla)	478	UniRef90_Q92777-2	Cluster: Isoform IIb of Synapsin-2	8

Protein	Similar proteins	Organisms	Length	Cluster ID	Cluster name	Size
Q92777	Q63537 UPI000A308696 UPI00093CF7EB UPI00072F90C3 UPI0005FAFFAC UPI0007870095 UPI000846FED1 UPI000A31537D Q64332 UPI00001ADE0A +121	Rattus norvegicus (Rat) Mus pahari (Gairdner's shrew-mouse) (Coelomys pahari) Hipposideros armiger (great roundleaf bat) Ovis aries (Sheep) Ovis aries musimon (Mouflon) Rousettus aegyptiacus (Egyptian rousette) (Egyptian fruit bat) Capra hircus (Goat) Mus caroli (Ryukyu mouse) (Ricefield mouse) Mus musculus (Mouse) Aotus nancymaae (Ma's night monkey) And more	586	UniRef50_Q63537	Cluster: Synapsin-2	132
Q92777-2	UPI0007629588 F7E5S8 UPI0003F0AF08 B4DI62 I7GBE8 Q59GM1 UPI0000EE2948 A0A097DC67 A0A0R4IS99 UPI0004986873 +89	Marmota marmota marmota (Alpine marmot) Callithrix jacchus (White-tufted-ear marmoset) Elephantulus edwardii (Cape long-eared elephant shrew) Homo sapiens (Human) Macaca fascicularis (Crab-eating macaque) (Cynomolgus monkey) Gorilla gorilla gorilla (Western lowland gorilla) Danio rerio (Zebrafish) (Brachydanio rerio) Cynoglossus semilaevis (Tongue sole) Takifugu rubripes (Japanese pufferfish) (Fugu rubripes) Scleropages formosus (Asian bonytongue) And more	478	UniRef50_Q92777-2	Cluster: Isoform IIb of Synapsin-2	100

Cross-referencesⁱ

Sequence databases

Select the link destinations: EMBLⁱ GenBankⁱ DDBJⁱ Links Updated	U40215 mRNA. Translation: AAC50718.1. AF077671 mRNA. Translation: AAC28368.1. AF077737 mRNA. Translation: AAC33789.1. AC022234 Genomic DNA. No translation available. AC026166 Genomic DNA. No translation available. AC091492 Genomic DNA. No translation available.
The Consensus CDS (CCDS) project More...CCDSⁱ	CCDS74900.1. [Q92777-1] CCDS74901.1. [Q92777-2]
NCBI Reference Sequences More...RefSeqⁱ	NP_003169.2. NM_003178.5.
UniGeneⁱ	Hs.445503.

3D structure databases

ProteinModelPortalⁱ	Q92777.
SMRⁱ	Q92777.
ModBaseⁱ	Search...
MobiDBⁱ	Search...

Protein-protein interaction databases

BioGridⁱ	112720. 14 interactors.
CORUMⁱ	Q92777.
IntActⁱ	Q92777. 1 interactor.

PTM databases

iPTMnetⁱ	Q92777.
PhosphoSitePlusⁱ	Q92777.

Polymorphism and mutation databases

DMDMⁱ	223634710.

DMDMⁱ

223634710.

2D gel databases

UCD-2DPAGEⁱ	Q92777.

UCD-2DPAGEⁱ

Q92777.

Proteomic databases

EPDⁱ	Q92777.
MaxQB - The MaxQuant DataBase More...MaxQBⁱ	Q92777.
PeptideAtlas More...PeptideAtlasⁱ	Q92777.
PRIDEⁱ	Q92777.

Protocols and materials databases

Structural Biology Knowledgebase	Search...

Structural Biology Knowledgebase

Search...

Genome annotation databases

GeneIDⁱ	6854.
KEGGⁱ	hsa:6854.

Organism-specific databases

CTDⁱ	6854.
DisGeNET More...DisGeNETⁱ	6854.
GeneCardsⁱ	SYN2.
Human Gene Nomenclature Database More...HGNCⁱ	HGNC:11495. SYN2.
Human Protein Atlas More...HPAⁱ	HPA037012.
MalaCards human disease database More...MalaCardsⁱ	SYN2.
MIMⁱ	600755. gene.
neXtProtⁱ	NX_Q92777.
GenAtlas: human gene database More...GenAtlasⁱ	Search...

Phylogenomic databases

HOVERGENⁱ	HBG016354.
InParanoidⁱ	Q92777.
KEGG Orthology (KO) More...KOⁱ	K19941.
PhylomeDBⁱ	Q92777.

Enzyme and pathway databases

Reactomeⁱ	R-HSA-181429. Serotonin Neurotransmitter Release Cycle. R-HSA-212676. Dopamine Neurotransmitter Release Cycle.
SIGNORⁱ	Q92777.

Miscellaneous databases

GenomeRNAiⁱ	6854.
Protein Ontology More...PROⁱ	PR:Q92777.
SOURCEⁱ	Search...

Gene expression databases

CleanExⁱ	HS_SYN2.

CleanExⁱ

HS_SYN2.

Family and domain databases

Gene3Dⁱ	3.30.1490.20. 1 hit.
InterProⁱ	View protein in InterPro IPR013815. ATP_grasp_subdomain_1. IPR016185. PreATP-grasp_dom. IPR001359. Synapsin. IPR020898. Synapsin_ATP-bd_dom. IPR019735. Synapsin_CS. IPR019736. Synapsin_P_site. IPR020897. Synapsin_pre-ATP-grasp_dom.
PANTHERⁱ	PTHR10841. PTHR10841. 1 hit.
Pfam protein domain database More...Pfamⁱ	View protein in Pfam PF02078. Synapsin. 1 hit. PF02750. Synapsin_C. 1 hit. PF10581. Synapsin_N. 1 hit.
PRINTSⁱ	PR01368. SYNAPSIN.
SUPFAMⁱ	SSF52440. SSF52440. 1 hit.
PROSITEⁱ	View protein in PROSITE PS00415. SYNAPSIN_1. 1 hit. PS00416. SYNAPSIN_2. 1 hit.
ProtoNetⁱ	Search...

Entry informationⁱ

Entry nameⁱ	SYN2_HUMAN
Accessionⁱ	Q92777Primary (citable) accession number: Q92777 Secondary accession number(s): A8MY98
Entry historyⁱ	Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
	Last sequence update:	February 10, 2009
	Last modified:	September 27, 2017
	This is version 142 of the entry and version 3 of the sequence. See complete history.
Entry statusⁱ	Reviewed (UniProtKB/Swiss-Prot)
Annotation program	Chordata Protein Annotation Program
Disclaimer	Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousⁱ

Caution

There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.Curated

Keywords - Technical termⁱ

Complete proteome, Reference proteome

Documents

Human chromosome 3
Human chromosome 3: entries, gene names and cross-references to MIM
Human entries with polymorphisms or disease mutations
List of human entries with polymorphisms or disease mutations
Human polymorphisms and disease mutations
Index of human polymorphisms and disease mutations
MIM cross-references
Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
SIMILARITY comments
Index of protein domains and families

UniProtKB

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Annotation systems

Supporting data

UniProtKB - Q92777 (SYN2_HUMAN)

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Synapsin-2

Select a section on the left to see content.

<p>This section provides any useful information about the protein, mostly biological knowledge.<p><a href='/help/function_section' target='_top'>More...</a></p>Functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Molecular functioni

<p>The <a href="http://www.geneontology.org/">Gene Ontology (GO)</a> project provides a set of hierarchical controlled vocabulary split into 3 categories:<p><a href='/help/gene_ontology' target='_top'>More...</a></p>GO - Biological processi

Enzyme and pathway databases

<p>This section provides information about the protein and gene name(s) and synonym(s) and about the organism that is the source of the protein sequence.<p><a href='/help/names_and_taxonomy_section' target='_top'>More...</a></p>Names & Taxonomyi

Organism-specific databases

<p>This section provides information on the location and the topology of the mature protein in the cell.<p><a href='/help/subcellular_location_section' target='_top'>More...</a></p>Subcellular locationi

Other locations

Other locations

<p>This section provides information on the disease(s) and phenotype(s) associated with a protein.<p><a href='/help/pathology_and_biotech_section' target='_top'>More...</a></p>Pathology & Biotechi

Organism-specific databases

Polymorphism and mutation databases

<p>This section describes post-translational modifications (PTMs) and/or processing events.<p><a href='/help/ptm_processing_section' target='_top'>More...</a></p>PTM / Processingi

Molecule processing

Amino acid modifications

Proteomic databases

2D gel databases

PTM databases

<p>This section provides information on the expression of a gene at the mRNA or protein level in cells or in tissues of multicellular organisms.<p><a href='/help/expression_section' target='_top'>More...</a></p>Expressioni

Gene expression databases

Organism-specific databases

<p>This section provides information on the quaternary structure of a protein and on interaction(s) with other proteins or protein complexes.<p><a href='/help/interaction_section' target='_top'>More...</a></p>Interactioni

Protein-protein interaction databases

<p>This section provides information on the tertiary and secondary structure of a protein.<p><a href='/help/structure_section' target='_top'>More...</a></p>Structurei

3D structure databases

<p>This section provides information on sequence similarities with other proteins and the domain(s) present in a protein.<p><a href='/help/family_and_domains_section' target='_top'>More...</a></p>Family & Domainsi

Region

Compositional bias

<p>This subsection of the ‘Family and domains’ section provides information about the sequence similarity with other proteins.<p><a href='/help/sequence_similarities' target='_top'>More...</a></p>Sequence similaritiesi

Phylogenomic databases

Family and domain databases

<p>This section displays by default the canonical protein sequence and upon request all isoforms described in the entry. It also includes information pertinent to the sequence(s), including length and molecular weight.<p><a href='/help/sequences_section' target='_top'>More...</a></p>Sequences (2)i

<p>This subsection of the ‘Sequence’ section reports difference(s) between the protein sequence shown in the UniProtKB entry and other available protein sequences derived from the same gene.<p><a href='/help/sequence_caution' target='_top'>More...</a></p>Sequence cautioni

Experimental Info

Natural variant

Alternative sequence

Sequence databases

Genome annotation databases

<p>This section is used to point to information related to entries and found in data collections other than UniProtKB.<p><a href='/help/cross_references_section' target='_top'>More...</a></p>Cross-referencesi

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Polymorphism and mutation databases

2D gel databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Enzyme and pathway databases

Miscellaneous databases

Gene expression databases

Family and domain databases

<p>This section provides general information on the entry.<p><a href='/help/entry_information_section' target='_top'>More...</a></p>Entry informationi

<p>This section contains any relevant information that doesn’t fit in any other defined sections<p><a href='/help/miscellaneous_section' target='_top'>More...</a></p>Miscellaneousi

Caution

Documents

Functionⁱ

GO - Molecular functionⁱ

GO - Biological processⁱ

Names & Taxonomyⁱ

Subcellular locationⁱ

Pathology & Biotechⁱ

PTM / Processingⁱ

Expressionⁱ

Interactionⁱ

Structureⁱ

Family & Domainsⁱ

Sequence similaritiesⁱ

Sequences (2)ⁱ

Sequence cautionⁱ

Cross-referencesⁱ

Entry informationⁱ

Miscellaneousⁱ