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Q92777 (SYN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 111. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Synapsin-2
Alternative name(s):
Synapsin II
Gene names
Name:SYN2
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length582 AA.
Sequence statusComplete.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release By similarity.

Subunit structure

Interacts with CAPON By similarity.

Subcellular location

Cell junctionsynapse.

Tissue specificity

Central and peripheral nervous systems.

Domain

The A region binds phospholipids with a preference for negatively charged species By similarity.

Post-translational modification

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles By similarity.

Sequence similarities

Belongs to the synapsin family.

Caution

There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.

Sequence caution

The sequence AC022234 differs from that shown. Reason: Frameshift at position 71.

The sequence AC022234 differs from that shown. Reason: Several in-frame stop codons.

Ontologies

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform IIa (identifier: Q92777-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform IIb (identifier: Q92777-2)

The sequence of this isoform differs from the canonical sequence as follows:
     458-480: GPGQPQGMQPPGKVLPPRRLPPG → CLQYILDCNGIAVGPKQVQAS
     481-582: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 582582Synapsin-2
PRO_0000183021

Regions

Region1 – 2929A
Region33 – 11280B; linker
Region113 – 420308C; actin-binding and synaptic-vesicle binding
Region421 – 45737G; Pro-rich linker
Region458 – 53376H; Pro/Ser-rich linker
Region534 – 58249E
Compositional bias34 – 429Poly-Pro
Compositional bias486 – 49611Poly-Ser
Compositional bias512 – 5165Poly-Ser

Amino acid modifications

Modified residue101Phosphoserine; by PKA and CaMK1 By similarity

Natural variations

Alternative sequence458 – 48023GPGQP…RLPPG → CLQYILDCNGIAVGPKQVQA S in isoform IIb.
VSP_006320
Alternative sequence481 – 582102Missing in isoform IIb.
VSP_006321
Natural variant5061T → A.
Corresponds to variant rs794999 [ dbSNP | Ensembl ].
VAR_059825

Experimental info

Sequence conflict341A → P Ref.1
Sequence conflict341A → P in AAC28368. Ref.2
Sequence conflict341A → P in AAC33789. Ref.2
Sequence conflict361T → P Ref.1
Sequence conflict361T → P in AAC28368. Ref.2
Sequence conflict361T → P in AAC33789. Ref.2
Sequence conflict611T → K in AAC28368. Ref.2
Sequence conflict611T → K in AAC33789. Ref.2
Sequence conflict611T → R in AAC50718. Ref.1
Sequence conflict641A → P Ref.1
Sequence conflict641A → P in AAC28368. Ref.2
Sequence conflict641A → P in AAC33789. Ref.2
Sequence conflict701P → A in AAC50718. Ref.1
Sequence conflict711P → Q Ref.1
Sequence conflict711P → Q in AAC28368. Ref.2
Sequence conflict711P → Q in AAC33789. Ref.2
Sequence conflict741R → P Ref.1
Sequence conflict741R → P in AAC28368. Ref.2
Sequence conflict741R → P in AAC33789. Ref.2
Sequence conflict821L → F Ref.1
Sequence conflict821L → F in AAC28368. Ref.2
Sequence conflict821L → F in AAC33789. Ref.2
Sequence conflict104 – 1052GA → AP Ref.1
Sequence conflict104 – 1052GA → AP in AAC28368. Ref.2
Sequence conflict104 – 1052GA → AP in AAC33789. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Isoform IIa [UniParc].

Last modified February 10, 2009. Version 3.
Checksum: 70BB0F77CCF9B1E1

FASTA58262,847
        10         20         30         40         50         60 
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA PPTASPGPER 

        70         80         90        100        110        120 
TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV DAPGAAPAAA RKAKVLLVVD 

       130        140        150        160        170        180 
EPHADWAKCF RGKKVLGDYD IKVEQAEFSE LNLVAHADGT YAVDMQVLRN GTKVVRSFRP 

       190        200        210        220        230        240 
DFVLIRQHAF GMAENEDFRH LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG 

       250        260        270        280        290        300 
GEKFPLIEQT YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 

       310        320        330        340        350        360 
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS DRYKLWVDTC 

       370        380        390        400        410        420 
SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV EDRQLITELV ISKMNQLLSR 

       430        440        450        460        470        480 
TPALSPQRPL TTQQPQSGTL KDPDSSKTPP QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG 

       490        500        510        520        530        540 
PSLPPSSSSS SSSSSSAPQR PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS 

       550        560        570        580 
QSLTNAFSFS ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD 

« Hide

Isoform IIb [UniParc].

Checksum: 8DF5B468E0E3BF81
Show »

FASTA47852,162

References

« Hide 'large scale' references
[1]"Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA."
Xie Y.
Gene 173:289-290(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB).
Tissue: Brain.
[2]"Cloning of cDNAs encoding human synapsins IIa and IIb."
Porton B., Kao H.-T., Greengard P.
DNA Seq. 10:49-54(1999) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB).
Tissue: Brain.
[3]"The DNA sequence, annotation and analysis of human chromosome 3."
Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. expand/collapse author list , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
U40215 mRNA. Translation: AAC50718.1.
AF077671 mRNA. Translation: AAC28368.1.
AF077737 mRNA. Translation: AAC33789.1.
AC022234 Genomic DNA. No translation available.
AC026166 Genomic DNA. No translation available.
AC091492 Genomic DNA. No translation available.
UniGeneHs.445503.

3D structure databases

ProteinModelPortalQ92777.
SMRQ92777. Positions 112-419.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ92777. 1 interaction.
STRING9606.ENSP00000342993.

PTM databases

PhosphoSiteQ92777.

Polymorphism databases

DMDM223634710.

2D gel databases

UCD-2DPAGEQ92777.

Proteomic databases

PaxDbQ92777.
PRIDEQ92777.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

GeneCardsGC03P012020.
HGNCHGNC:11495. SYN2.
MIM600755. gene.
neXtProtNX_Q92777.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG284201.
HOVERGENHBG016354.
InParanoidQ92777.
PhylomeDBQ92777.

Enzyme and pathway databases

ReactomeREACT_13685. Neuronal System.

Gene expression databases

CleanExHS_SYN2.
GenevestigatorQ92777.

Family and domain databases

Gene3D3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR028710. Syn2.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERPTHR10841:SF7. PTHR10841:SF7. 1 hit.
PfamPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSPR01368. SYNAPSIN.
SUPFAMSSF52440. SSF52440. 1 hit.
PROSITEPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ92777.
SOURCESearch...

Entry information

Entry nameSYN2_HUMAN
AccessionPrimary (citable) accession number: Q92777
Secondary accession number(s): A8MY98
Entry history
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 3

Human chromosome 3: entries, gene names and cross-references to MIM