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Q92777

- SYN2_HUMAN

UniProt

Q92777 - SYN2_HUMAN

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Protein

Synapsin-2

Gene

SYN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

GO - Molecular functioni

  1. ATP binding Source: ParkinsonsUK-UCL
  2. catalytic activity Source: InterPro

GO - Biological processi

  1. neurotransmitter secretion Source: InterPro
  2. synaptic transmission Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

ReactomeiREACT_15293. Dopamine Neurotransmitter Release Cycle.
REACT_15425. Serotonin Neurotransmitter Release Cycle.

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-2
Alternative name(s):
Synapsin II
Gene namesi
Name:SYN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Unplaced

Organism-specific databases

HGNCiHGNC:11495. SYN2.

Subcellular locationi

GO - Cellular componenti

  1. cell junction Source: UniProtKB-KW
  2. synaptic vesicle Source: InterPro
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 582582Synapsin-2PRO_0000183021Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei10 – 101Phosphoserine; by PKA and CaMK1By similarity
Modified residuei425 – 4251PhosphoserineBy similarity

Post-translational modificationi

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

MaxQBiQ92777.
PaxDbiQ92777.
PRIDEiQ92777.

2D gel databases

UCD-2DPAGEQ92777.

PTM databases

PhosphoSiteiQ92777.

Expressioni

Tissue specificityi

Central and peripheral nervous systems.

Gene expression databases

CleanExiHS_SYN2.
GenevestigatoriQ92777.

Interactioni

Subunit structurei

Interacts with CAPON.By similarity

Protein-protein interaction databases

IntActiQ92777. 1 interaction.
STRINGi9606.ENSP00000342993.

Structurei

3D structure databases

ProteinModelPortaliQ92777.
SMRiQ92777. Positions 112-419.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 2929AAdd
BLAST
Regioni33 – 11280B; linkerAdd
BLAST
Regioni113 – 420308C; actin-binding and synaptic-vesicle bindingAdd
BLAST
Regioni421 – 45737G; Pro-rich linkerAdd
BLAST
Regioni458 – 53376H; Pro/Ser-rich linkerAdd
BLAST
Regioni534 – 58249EAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi34 – 429Poly-Pro
Compositional biasi486 – 49611Poly-SerAdd
BLAST
Compositional biasi512 – 5165Poly-Ser

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

eggNOGiNOG284201.
HOVERGENiHBG016354.
InParanoidiQ92777.
PhylomeDBiQ92777.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform IIa (identifier: Q92777-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA
60 70 80 90 100
PPTASPGPER TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV
110 120 130 140 150
DAPGAAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE
160 170 180 190 200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH
210 220 230 240 250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT
260 270 280 290 300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT
310 320 330 340 350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV
410 420 430 440 450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP
460 470 480 490 500
QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR
510 520 530 540 550
PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS
560 570 580
ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD
Length:582
Mass (Da):62,847
Last modified:February 10, 2009 - v3
Checksum:i70BB0F77CCF9B1E1
GO
Isoform IIb (identifier: Q92777-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-480: GPGQPQGMQPPGKVLPPRRLPPG → CLQYILDCNGIAVGPKQVQAS
     481-582: Missing.

Show »
Length:478
Mass (Da):52,162
Checksum:i8DF5B468E0E3BF81
GO

Sequence cautioni

The sequence AC022234 differs from that shown. Reason: Several in-frame stop codons.Curated
The sequence AC022234 differs from that shown. Reason: Frameshift at position 71. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti34 – 341A → P in AAC50718. (PubMed:8964517)Curated
Sequence conflicti34 – 341A → P in AAC28368. (PubMed:10565545)Curated
Sequence conflicti34 – 341A → P in AAC33789. (PubMed:10565545)Curated
Sequence conflicti36 – 361T → P in AAC50718. (PubMed:8964517)Curated
Sequence conflicti36 – 361T → P in AAC28368. (PubMed:10565545)Curated
Sequence conflicti36 – 361T → P in AAC33789. (PubMed:10565545)Curated
Sequence conflicti61 – 611T → K in AAC28368. (PubMed:10565545)Curated
Sequence conflicti61 – 611T → K in AAC33789. (PubMed:10565545)Curated
Sequence conflicti61 – 611T → R in AAC50718. (PubMed:8964517)Curated
Sequence conflicti64 – 641A → P in AAC50718. (PubMed:8964517)Curated
Sequence conflicti64 – 641A → P in AAC28368. (PubMed:10565545)Curated
Sequence conflicti64 – 641A → P in AAC33789. (PubMed:10565545)Curated
Sequence conflicti70 – 701P → A in AAC50718. (PubMed:8964517)Curated
Sequence conflicti71 – 711P → Q in AAC50718. (PubMed:8964517)Curated
Sequence conflicti71 – 711P → Q in AAC28368. (PubMed:10565545)Curated
Sequence conflicti71 – 711P → Q in AAC33789. (PubMed:10565545)Curated
Sequence conflicti74 – 741R → P in AAC50718. (PubMed:8964517)Curated
Sequence conflicti74 – 741R → P in AAC28368. (PubMed:10565545)Curated
Sequence conflicti74 – 741R → P in AAC33789. (PubMed:10565545)Curated
Sequence conflicti82 – 821L → F in AAC50718. (PubMed:8964517)Curated
Sequence conflicti82 – 821L → F in AAC28368. (PubMed:10565545)Curated
Sequence conflicti82 – 821L → F in AAC33789. (PubMed:10565545)Curated
Sequence conflicti104 – 1052GA → AP in AAC50718. (PubMed:8964517)Curated
Sequence conflicti104 – 1052GA → AP in AAC28368. (PubMed:10565545)Curated
Sequence conflicti104 – 1052GA → AP in AAC33789. (PubMed:10565545)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti506 – 5061T → A.
Corresponds to variant rs794999 [ dbSNP | Ensembl ].
VAR_059825

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei458 – 48023GPGQP…RLPPG → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsVSP_006320Add
BLAST
Alternative sequencei481 – 582102Missing in isoform IIb. 2 PublicationsVSP_006321Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40215 mRNA. Translation: AAC50718.1.
AF077671 mRNA. Translation: AAC28368.1.
AF077737 mRNA. Translation: AAC33789.1.
AC022234 Genomic DNA. No translation available.
AC026166 Genomic DNA. No translation available.
AC091492 Genomic DNA. No translation available.
CCDSiCCDS74900.1. [Q92777-1]
CCDS74901.1. [Q92777-2]
RefSeqiNP_003169.2. NM_003178.5.
UniGeneiHs.445503.

Genome annotation databases

GeneIDi6854.
KEGGihsa:6854.

Polymorphism databases

DMDMi223634710.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40215 mRNA. Translation: AAC50718.1 .
AF077671 mRNA. Translation: AAC28368.1 .
AF077737 mRNA. Translation: AAC33789.1 .
AC022234 Genomic DNA. No translation available.
AC026166 Genomic DNA. No translation available.
AC091492 Genomic DNA. No translation available.
CCDSi CCDS74900.1. [Q92777-1 ]
CCDS74901.1. [Q92777-2 ]
RefSeqi NP_003169.2. NM_003178.5.
UniGenei Hs.445503.

3D structure databases

ProteinModelPortali Q92777.
SMRi Q92777. Positions 112-419.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q92777. 1 interaction.
STRINGi 9606.ENSP00000342993.

PTM databases

PhosphoSitei Q92777.

Polymorphism databases

DMDMi 223634710.

2D gel databases

UCD-2DPAGE Q92777.

Proteomic databases

MaxQBi Q92777.
PaxDbi Q92777.
PRIDEi Q92777.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 6854.
KEGGi hsa:6854.

Organism-specific databases

CTDi 6854.
GeneCardsi GC03P012020.
HGNCi HGNC:11495. SYN2.
MIMi 600755. gene.
neXtProti NX_Q92777.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG284201.
HOVERGENi HBG016354.
InParanoidi Q92777.
PhylomeDBi Q92777.

Enzyme and pathway databases

Reactomei REACT_15293. Dopamine Neurotransmitter Release Cycle.
REACT_15425. Serotonin Neurotransmitter Release Cycle.

Miscellaneous databases

GenomeRNAii 6854.
PROi Q92777.
SOURCEi Search...

Gene expression databases

CleanExi HS_SYN2.
Genevestigatori Q92777.

Family and domain databases

Gene3Di 3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProi IPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view ]
PANTHERi PTHR10841. PTHR10841. 1 hit.
Pfami PF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view ]
PRINTSi PR01368. SYNAPSIN.
SUPFAMi SSF52440. SSF52440. 1 hit.
PROSITEi PS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA."
    Xie Y.
    Gene 173:289-290(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB).
    Tissue: Brain.
  2. "Cloning of cDNAs encoding human synapsins IIa and IIb."
    Porton B., Kao H.-T., Greengard P.
    DNA Seq. 10:49-54(1999) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB).
    Tissue: Brain.
  3. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiSYN2_HUMAN
AccessioniPrimary (citable) accession number: Q92777
Secondary accession number(s): A8MY98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: October 29, 2014
This is version 117 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3