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Protein

Synapsin-2

Gene

SYN2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

GO - Molecular functioni

  • ATP binding Source: ParkinsonsUK-UCL
  • catalytic activity Source: InterPro

GO - Biological processi

  • chemical synaptic transmission Source: ProtInc
  • neurotransmitter secretion Source: ParkinsonsUK-UCL
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157152-MONOMER.
ReactomeiR-HSA-181429. Serotonin Neurotransmitter Release Cycle.
R-HSA-212676. Dopamine Neurotransmitter Release Cycle.
SIGNORiQ92777.

Names & Taxonomyi

Protein namesi
Recommended name:
Synapsin-2
Alternative name(s):
Synapsin II
Gene namesi
Name:SYN2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:11495. SYN2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Synapse

Pathology & Biotechi

Organism-specific databases

DisGeNETi6854.
MalaCardsiSYN2.

Polymorphism and mutation databases

DMDMi223634710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001830211 – 582Synapsin-2Add BLAST582

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei10Phosphoserine; by PKA and CaMK1By similarity1
Modified residuei421PhosphothreonineBy similarity1
Modified residuei425PhosphoserineBy similarity1

Post-translational modificationi

Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons (By similarity).By similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92777.
MaxQBiQ92777.
PeptideAtlasiQ92777.
PRIDEiQ92777.

2D gel databases

UCD-2DPAGEQ92777.

PTM databases

iPTMnetiQ92777.
PhosphoSitePlusiQ92777.

Expressioni

Tissue specificityi

Central and peripheral nervous systems.

Gene expression databases

CleanExiHS_SYN2.

Interactioni

Subunit structurei

Interacts with CAPON.By similarity

Protein-protein interaction databases

BioGridi112720. 14 interactors.
IntActiQ92777. 1 interactor.

Structurei

3D structure databases

ProteinModelPortaliQ92777.
SMRiQ92777.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 29AAdd BLAST29
Regioni33 – 112B; linkerAdd BLAST80
Regioni113 – 420C; actin-binding and synaptic-vesicle bindingAdd BLAST308
Regioni421 – 457G; Pro-rich linkerAdd BLAST37
Regioni458 – 533H; Pro/Ser-rich linkerAdd BLAST76
Regioni534 – 582EAdd BLAST49

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi34 – 42Poly-Pro9
Compositional biasi486 – 496Poly-SerAdd BLAST11
Compositional biasi512 – 516Poly-Ser5

Domaini

The A region binds phospholipids with a preference for negatively charged species.By similarity

Sequence similaritiesi

Belongs to the synapsin family.Curated

Phylogenomic databases

HOVERGENiHBG016354.
InParanoidiQ92777.
KOiK19941.
PhylomeDBiQ92777.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform IIa (identifier: Q92777-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA
60 70 80 90 100
PPTASPGPER TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV
110 120 130 140 150
DAPGAAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE
160 170 180 190 200
LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH
210 220 230 240 250
LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT
260 270 280 290 300
YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT
310 320 330 340 350
YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS
360 370 380 390 400
DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV
410 420 430 440 450
EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP
460 470 480 490 500
QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR
510 520 530 540 550
PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS
560 570 580
ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD
Length:582
Mass (Da):62,847
Last modified:February 10, 2009 - v3
Checksum:i70BB0F77CCF9B1E1
GO
Isoform IIb (identifier: Q92777-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     458-480: GPGQPQGMQPPGKVLPPRRLPPG → CLQYILDCNGIAVGPKQVQAS
     481-582: Missing.

Show »
Length:478
Mass (Da):52,162
Checksum:i8DF5B468E0E3BF81
GO

Sequence cautioni

The sequence AC022234 differs from that shown. Several in-frame stop codons.Curated
The sequence AC022234 differs from that shown. Reason: Frameshift at position 71.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti34A → P in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti34A → P in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti34A → P in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti36T → P in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti36T → P in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti36T → P in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti61T → K in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti61T → K in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti61T → R in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti64A → P in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti64A → P in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti64A → P in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti70P → A in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti71P → Q in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti71P → Q in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti71P → Q in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti74R → P in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti74R → P in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti74R → P in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti82L → F in AAC50718 (PubMed:8964517).Curated1
Sequence conflicti82L → F in AAC28368 (PubMed:10565545).Curated1
Sequence conflicti82L → F in AAC33789 (PubMed:10565545).Curated1
Sequence conflicti104 – 105GA → AP in AAC50718 (PubMed:8964517).Curated2
Sequence conflicti104 – 105GA → AP in AAC28368 (PubMed:10565545).Curated2
Sequence conflicti104 – 105GA → AP in AAC33789 (PubMed:10565545).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_059825506T → A.Corresponds to variant rs794999dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_006320458 – 480GPGQP…RLPPG → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsAdd BLAST23
Alternative sequenceiVSP_006321481 – 582Missing in isoform IIb. 2 PublicationsAdd BLAST102

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40215 mRNA. Translation: AAC50718.1.
AF077671 mRNA. Translation: AAC28368.1.
AF077737 mRNA. Translation: AAC33789.1.
AC022234 Genomic DNA. No translation available.
AC026166 Genomic DNA. No translation available.
AC091492 Genomic DNA. No translation available.
CCDSiCCDS74900.1. [Q92777-1]
CCDS74901.1. [Q92777-2]
RefSeqiNP_003169.2. NM_003178.5.
UniGeneiHs.445503.

Genome annotation databases

GeneIDi6854.
KEGGihsa:6854.

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U40215 mRNA. Translation: AAC50718.1.
AF077671 mRNA. Translation: AAC28368.1.
AF077737 mRNA. Translation: AAC33789.1.
AC022234 Genomic DNA. No translation available.
AC026166 Genomic DNA. No translation available.
AC091492 Genomic DNA. No translation available.
CCDSiCCDS74900.1. [Q92777-1]
CCDS74901.1. [Q92777-2]
RefSeqiNP_003169.2. NM_003178.5.
UniGeneiHs.445503.

3D structure databases

ProteinModelPortaliQ92777.
SMRiQ92777.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112720. 14 interactors.
IntActiQ92777. 1 interactor.

PTM databases

iPTMnetiQ92777.
PhosphoSitePlusiQ92777.

Polymorphism and mutation databases

DMDMi223634710.

2D gel databases

UCD-2DPAGEQ92777.

Proteomic databases

EPDiQ92777.
MaxQBiQ92777.
PeptideAtlasiQ92777.
PRIDEiQ92777.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi6854.
KEGGihsa:6854.

Organism-specific databases

CTDi6854.
DisGeNETi6854.
GeneCardsiSYN2.
HGNCiHGNC:11495. SYN2.
MalaCardsiSYN2.
MIMi600755. gene.
neXtProtiNX_Q92777.
GenAtlasiSearch...

Phylogenomic databases

HOVERGENiHBG016354.
InParanoidiQ92777.
KOiK19941.
PhylomeDBiQ92777.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000157152-MONOMER.
ReactomeiR-HSA-181429. Serotonin Neurotransmitter Release Cycle.
R-HSA-212676. Dopamine Neurotransmitter Release Cycle.
SIGNORiQ92777.

Miscellaneous databases

GenomeRNAii6854.
PROiQ92777.
SOURCEiSearch...

Gene expression databases

CleanExiHS_SYN2.

Family and domain databases

Gene3Di3.30.1490.20. 1 hit.
3.30.470.20. 2 hits.
3.40.50.20. 1 hit.
InterProiIPR013815. ATP_grasp_subdomain_1.
IPR013816. ATP_grasp_subdomain_2.
IPR016185. PreATP-grasp_dom.
IPR001359. Synapsin.
IPR020898. Synapsin_ATP-bd_dom.
IPR019735. Synapsin_CS.
IPR019736. Synapsin_P_site.
IPR020897. Synapsin_pre-ATP-grasp_dom.
[Graphical view]
PANTHERiPTHR10841. PTHR10841. 1 hit.
PfamiPF02078. Synapsin. 1 hit.
PF02750. Synapsin_C. 1 hit.
PF10581. Synapsin_N. 1 hit.
[Graphical view]
PRINTSiPR01368. SYNAPSIN.
SUPFAMiSSF52440. SSF52440. 1 hit.
PROSITEiPS00415. SYNAPSIN_1. 1 hit.
PS00416. SYNAPSIN_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiSYN2_HUMAN
AccessioniPrimary (citable) accession number: Q92777
Secondary accession number(s): A8MY98
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 30, 2000
Last sequence update: February 10, 2009
Last modified: November 2, 2016
This is version 134 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.