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Q92777

- SYN2_HUMAN

UniProt

Q92777 - SYN2_HUMAN

Protein

Synapsin-2

Gene

SYN2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 116 (01 Oct 2014)
      Sequence version 3 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release. May play a role in noradrenaline secretion by sympathetic neurons By similarity.By similarity

    GO - Molecular functioni

    1. ATP binding Source: InterPro
    2. catalytic activity Source: InterPro

    GO - Biological processi

    1. neurotransmitter secretion Source: InterPro
    2. synaptic transmission Source: ProtInc

    Enzyme and pathway databases

    ReactomeiREACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Synapsin-2
    Alternative name(s):
    Synapsin II
    Gene namesi
    Name:SYN2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Unplaced

    Organism-specific databases

    HGNCiHGNC:11495. SYN2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell junction Source: UniProtKB-KW
    2. synaptic vesicle Source: InterPro

    Keywords - Cellular componenti

    Cell junction, Synapse

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 582582Synapsin-2PRO_0000183021Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei10 – 101Phosphoserine; by PKA and CaMK1By similarity
    Modified residuei425 – 4251PhosphoserineBy similarity

    Post-translational modificationi

    Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles. Phosphorylation at Ser-425 by MAPK1/ERK2 and/or MAPK3/ERK1 may play a role in noradrenaline secretion by sympathetic neurons By similarity.By similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    MaxQBiQ92777.
    PaxDbiQ92777.
    PRIDEiQ92777.

    2D gel databases

    UCD-2DPAGEQ92777.

    PTM databases

    PhosphoSiteiQ92777.

    Expressioni

    Tissue specificityi

    Central and peripheral nervous systems.

    Gene expression databases

    CleanExiHS_SYN2.
    GenevestigatoriQ92777.

    Interactioni

    Subunit structurei

    Interacts with CAPON.By similarity

    Protein-protein interaction databases

    IntActiQ92777. 1 interaction.
    STRINGi9606.ENSP00000342993.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92777.
    SMRiQ92777. Positions 112-419.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 2929AAdd
    BLAST
    Regioni33 – 11280B; linkerAdd
    BLAST
    Regioni113 – 420308C; actin-binding and synaptic-vesicle bindingAdd
    BLAST
    Regioni421 – 45737G; Pro-rich linkerAdd
    BLAST
    Regioni458 – 53376H; Pro/Ser-rich linkerAdd
    BLAST
    Regioni534 – 58249EAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi34 – 429Poly-Pro
    Compositional biasi486 – 49611Poly-SerAdd
    BLAST
    Compositional biasi512 – 5165Poly-Ser

    Domaini

    The A region binds phospholipids with a preference for negatively charged species.By similarity

    Sequence similaritiesi

    Belongs to the synapsin family.Curated

    Phylogenomic databases

    eggNOGiNOG284201.
    HOVERGENiHBG016354.
    InParanoidiQ92777.
    PhylomeDBiQ92777.

    Family and domain databases

    Gene3Di3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProiIPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view]
    PANTHERiPTHR10841. PTHR10841. 1 hit.
    PfamiPF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view]
    PRINTSiPR01368. SYNAPSIN.
    SUPFAMiSSF52440. SSF52440. 1 hit.
    PROSITEiPS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform IIa (identifier: Q92777-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA    50
    PPTASPGPER TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV 100
    DAPGAAPAAA RKAKVLLVVD EPHADWAKCF RGKKVLGDYD IKVEQAEFSE 150
    LNLVAHADGT YAVDMQVLRN GTKVVRSFRP DFVLIRQHAF GMAENEDFRH 200
    LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG GEKFPLIEQT 250
    YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 300
    YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS 350
    DRYKLWVDTC SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV 400
    EDRQLITELV ISKMNQLLSR TPALSPQRPL TTQQPQSGTL KDPDSSKTPP 450
    QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG PSLPPSSSSS SSSSSSAPQR 500
    PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS QSLTNAFSFS 550
    ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD 582
    Length:582
    Mass (Da):62,847
    Last modified:February 10, 2009 - v3
    Checksum:i70BB0F77CCF9B1E1
    GO
    Isoform IIb (identifier: Q92777-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         458-480: GPGQPQGMQPPGKVLPPRRLPPG → CLQYILDCNGIAVGPKQVQAS
         481-582: Missing.

    Show »
    Length:478
    Mass (Da):52,162
    Checksum:i8DF5B468E0E3BF81
    GO

    Sequence cautioni

    The sequence AC022234 differs from that shown. Reason: Several in-frame stop codons.
    The sequence AC022234 differs from that shown. Reason: Frameshift at position 71.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti34 – 341A → P in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti34 – 341A → P in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti34 – 341A → P in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti36 – 361T → P in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti36 – 361T → P in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti36 – 361T → P in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti61 – 611T → K in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti61 – 611T → K in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti61 – 611T → R in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti64 – 641A → P in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti64 – 641A → P in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti64 – 641A → P in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti70 – 701P → A in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti71 – 711P → Q in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti71 – 711P → Q in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti71 – 711P → Q in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti74 – 741R → P in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti74 – 741R → P in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti74 – 741R → P in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti82 – 821L → F in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti82 – 821L → F in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti82 – 821L → F in AAC33789. (PubMed:10565545)Curated
    Sequence conflicti104 – 1052GA → AP in AAC50718. (PubMed:8964517)Curated
    Sequence conflicti104 – 1052GA → AP in AAC28368. (PubMed:10565545)Curated
    Sequence conflicti104 – 1052GA → AP in AAC33789. (PubMed:10565545)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti506 – 5061T → A.
    Corresponds to variant rs794999 [ dbSNP | Ensembl ].
    VAR_059825

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei458 – 48023GPGQP…RLPPG → CLQYILDCNGIAVGPKQVQA S in isoform IIb. 2 PublicationsVSP_006320Add
    BLAST
    Alternative sequencei481 – 582102Missing in isoform IIb. 2 PublicationsVSP_006321Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40215 mRNA. Translation: AAC50718.1.
    AF077671 mRNA. Translation: AAC28368.1.
    AF077737 mRNA. Translation: AAC33789.1.
    AC022234 Genomic DNA. No translation available.
    AC026166 Genomic DNA. No translation available.
    AC091492 Genomic DNA. No translation available.
    RefSeqiNP_003169.2. NM_003178.5.
    UniGeneiHs.445503.

    Genome annotation databases

    GeneIDi6854.
    KEGGihsa:6854.

    Polymorphism databases

    DMDMi223634710.

    Keywords - Coding sequence diversityi

    Alternative splicing, Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U40215 mRNA. Translation: AAC50718.1 .
    AF077671 mRNA. Translation: AAC28368.1 .
    AF077737 mRNA. Translation: AAC33789.1 .
    AC022234 Genomic DNA. No translation available.
    AC026166 Genomic DNA. No translation available.
    AC091492 Genomic DNA. No translation available.
    RefSeqi NP_003169.2. NM_003178.5.
    UniGenei Hs.445503.

    3D structure databases

    ProteinModelPortali Q92777.
    SMRi Q92777. Positions 112-419.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q92777. 1 interaction.
    STRINGi 9606.ENSP00000342993.

    PTM databases

    PhosphoSitei Q92777.

    Polymorphism databases

    DMDMi 223634710.

    2D gel databases

    UCD-2DPAGE Q92777.

    Proteomic databases

    MaxQBi Q92777.
    PaxDbi Q92777.
    PRIDEi Q92777.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 6854.
    KEGGi hsa:6854.

    Organism-specific databases

    CTDi 6854.
    GeneCardsi GC03P012020.
    HGNCi HGNC:11495. SYN2.
    MIMi 600755. gene.
    neXtProti NX_Q92777.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG284201.
    HOVERGENi HBG016354.
    InParanoidi Q92777.
    PhylomeDBi Q92777.

    Enzyme and pathway databases

    Reactomei REACT_15293. Dopamine Neurotransmitter Release Cycle.
    REACT_15425. Serotonin Neurotransmitter Release Cycle.

    Miscellaneous databases

    PROi Q92777.
    SOURCEi Search...

    Gene expression databases

    CleanExi HS_SYN2.
    Genevestigatori Q92777.

    Family and domain databases

    Gene3Di 3.30.1490.20. 1 hit.
    3.30.470.20. 2 hits.
    3.40.50.20. 1 hit.
    InterProi IPR013815. ATP_grasp_subdomain_1.
    IPR013816. ATP_grasp_subdomain_2.
    IPR016185. PreATP-grasp_dom.
    IPR001359. Synapsin.
    IPR020898. Synapsin_ATP-bd_dom.
    IPR019735. Synapsin_CS.
    IPR019736. Synapsin_P_site.
    IPR020897. Synapsin_pre-ATP-grasp_dom.
    [Graphical view ]
    PANTHERi PTHR10841. PTHR10841. 1 hit.
    Pfami PF02078. Synapsin. 1 hit.
    PF02750. Synapsin_C. 1 hit.
    PF10581. Synapsin_N. 1 hit.
    [Graphical view ]
    PRINTSi PR01368. SYNAPSIN.
    SUPFAMi SSF52440. SSF52440. 1 hit.
    PROSITEi PS00415. SYNAPSIN_1. 1 hit.
    PS00416. SYNAPSIN_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA."
      Xie Y.
      Gene 173:289-290(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB).
      Tissue: Brain.
    2. "Cloning of cDNAs encoding human synapsins IIa and IIb."
      Porton B., Kao H.-T., Greengard P.
      DNA Seq. 10:49-54(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB).
      Tissue: Brain.
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiSYN2_HUMAN
    AccessioniPrimary (citable) accession number: Q92777
    Secondary accession number(s): A8MY98
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 30, 2000
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 116 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Caution

    There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.Curated

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3