Q92777 (SYN2_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Synapsin-2

Alternative name(s):
Synapsin II

Gene names

Name:

SYN2

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Dipnotetrapodomorpha › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Boreoeutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	582 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Neuronal phosphoprotein that coats synaptic vesicles, binds to the cytoskeleton, and is believed to function in the regulation of neurotransmitter release By similarity.
Subunit structure	Interacts with CAPON By similarity.
Subcellular location	Cell junction › synapse.
Tissue specificity	Central and peripheral nervous systems.
Domain	The A region binds phospholipids with a preference for negatively charged species By similarity.
Post-translational modification	Phosphorylation at Ser-10 dissociates synapsins from synaptic vesicles By similarity.
Sequence similarities	Belongs to the synapsin family.
Caution	There are several mRNAs and ESTs supporting this gene model. However, the genome sequence encoding the N-terminal part contains several sequence discrepancies.
Sequence caution	The sequence AC022234 differs from that shown. Reason: Frameshift at position 71. The sequence AC022234 differs from that shown. Reason: Several in-frame stop codons.

Ontologies

Keywords
Cellular component	Cell junction Synapse
Coding sequence diversity	Alternative splicing Polymorphism
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	neurotransmitter secretion Inferred from electronic annotation. Source: InterPro synaptic transmission Traceable author statement Ref.1. Source: ProtInc
Cellular_component	cell junction Inferred from electronic annotation. Source: UniProtKB-KW synaptic vesicle membrane Inferred from electronic annotation. Source: InterPro
Molecular_function	ATP binding Inferred from electronic annotation. Source: InterPro catalytic activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform IIa (identifier: Q92777-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform IIb (identifier: Q92777-2)

The sequence of this isoform differs from the canonical sequence as follows:
     458-480: GPGQPQGMQPPGKVLPPRRLPPG → CLQYILDCNGIAVGPKQVQAS
     481-582: Missing.

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 582	582	Synapsin-2		PRO_0000183021
Regions
	Region	1 – 29	29	A
	Region	33 – 112	80	B; linker
	Region	113 – 420	308	C; actin-binding and synaptic-vesicle binding
	Region	421 – 457	37	G; Pro-rich linker
	Region	458 – 533	76	H; Pro/Ser-rich linker
	Region	534 – 582	49	E
	Compositional bias	34 – 42	9	Poly-Pro
	Compositional bias	486 – 496	11	Poly-Ser
	Compositional bias	512 – 516	5	Poly-Ser
Amino acid modifications
	Modified residue	10	1	Phosphoserine; by PKA and CaMK1 By similarity
Natural variations
	Alternative sequence	458 – 480	23	GPGQP…RLPPG → CLQYILDCNGIAVGPKQVQA S in isoform IIb.		VSP_006320
	Alternative sequence	481 – 582	102	Missing in isoform IIb.		VSP_006321
	Natural variant	506	1	T → A. Corresponds to variant rs794999 [ dbSNP | Ensembl ].		VAR_059825
Experimental info
	Sequence conflict	34	1	A → P Ref.1
	Sequence conflict	34	1	A → P in AAC28368. Ref.2
	Sequence conflict	34	1	A → P in AAC33789. Ref.2
	Sequence conflict	36	1	T → P Ref.1
	Sequence conflict	36	1	T → P in AAC28368. Ref.2
	Sequence conflict	36	1	T → P in AAC33789. Ref.2
	Sequence conflict	61	1	T → K in AAC28368. Ref.2
	Sequence conflict	61	1	T → K in AAC33789. Ref.2
	Sequence conflict	61	1	T → R in AAC50718. Ref.1
	Sequence conflict	64	1	A → P Ref.1
	Sequence conflict	64	1	A → P in AAC28368. Ref.2
	Sequence conflict	64	1	A → P in AAC33789. Ref.2
	Sequence conflict	70	1	P → A in AAC50718. Ref.1
	Sequence conflict	71	1	P → Q Ref.1
	Sequence conflict	71	1	P → Q in AAC28368. Ref.2
	Sequence conflict	71	1	P → Q in AAC33789. Ref.2
	Sequence conflict	74	1	R → P Ref.1
	Sequence conflict	74	1	R → P in AAC28368. Ref.2
	Sequence conflict	74	1	R → P in AAC33789. Ref.2
	Sequence conflict	82	1	L → F Ref.1
	Sequence conflict	82	1	L → F in AAC28368. Ref.2
	Sequence conflict	82	1	L → F in AAC33789. Ref.2
	Sequence conflict	104 – 105	2	GA → AP Ref.1
	Sequence conflict	104 – 105	2	GA → AP in AAC28368. Ref.2
	Sequence conflict	104 – 105	2	GA → AP in AAC33789. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Isoform IIa [UniParc]. Last modified February 10, 2009. Version 3. Checksum: 70BB0F77CCF9B1E1	FASTA	582	62,847
	10 20 30 40 50 60 MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA PPTASPGPER 70 80 90 100 110 120 TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV DAPGAAPAAA RKAKVLLVVD 130 140 150 160 170 180 EPHADWAKCF RGKKVLGDYD IKVEQAEFSE LNLVAHADGT YAVDMQVLRN GTKVVRSFRP 190 200 210 220 230 240 DFVLIRQHAF GMAENEDFRH LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG 250 260 270 280 290 300 GEKFPLIEQT YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 310 320 330 340 350 360 YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS DRYKLWVDTC 370 380 390 400 410 420 SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV EDRQLITELV ISKMNQLLSR 430 440 450 460 470 480 TPALSPQRPL TTQQPQSGTL KDPDSSKTPP QRPPPQGGPG QPQGMQPPGK VLPPRRLPPG 490 500 510 520 530 540 PSLPPSSSSS SSSSSSAPQR PGGPTTHGDA PSSSSSLAEA QPPLAAPPQK PQPHPQLNKS 550 560 570 580 QSLTNAFSFS ESSFFRSSAN EDEAKAETIR SLRKSFASLF SD
	Isoform IIb [UniParc]. Checksum: 8DF5B468E0E3BF81	FASTA	478	52,162
	10 20 30 40 50 60 MMNFLRRRLS DSSFIANLPN GYMTDLQRPE PQQAPTPPPP GPGAASASAA PPTASPGPER 70 80 90 100 110 120 TPPAASAPAP PPARTPSVGS SLFSSLSQAV KQTAASAGLV DAPGAAPAAA RKAKVLLVVD 130 140 150 160 170 180 EPHADWAKCF RGKKVLGDYD IKVEQAEFSE LNLVAHADGT YAVDMQVLRN GTKVVRSFRP 190 200 210 220 230 240 DFVLIRQHAF GMAENEDFRH LIIGMQYAGL PSINSLESIY NFCDKPWVFA QLVAIYKTLG 250 260 270 280 290 300 GEKFPLIEQT YYPNHKEMLT LPTFPVVVKI GHAHSGMGKV KVENHYDFQD IASVVALTQT 310 320 330 340 350 360 YATAEPFIDS KYDIRVQKIG NNYKAYMRTS ISGNWKTNTG SAMLEQIAMS DRYKLWVDTC 370 380 390 400 410 420 SEMFGGLDIC AVKAVHGKDG KDYIFEVMDC SMPLIGEHQV EDRQLITELV ISKMNQLLSR 430 440 450 460 470 TPALSPQRPL TTQQPQSGTL KDPDSSKTPP QRPPPQGCLQ YILDCNGIAV GPKQVQAS

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning and sequencing analysis of a human synapsin IIb-encoding brain cDNA." Xie Y. Gene 173:289-290(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM IIB). Tissue: Brain.
[2]	"Cloning of cDNAs encoding human synapsins IIa and IIb." Porton B., Kao H.-T., Greengard P. DNA Seq. 10:49-54(1999) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS IIA AND IIB). Tissue: Brain.
[3]	"The DNA sequence, annotation and analysis of human chromosome 3." Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J. , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A. Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	U40215 mRNA. Translation: AAC50718.1. AF077671 mRNA. Translation: AAC28368.1. AF077737 mRNA. Translation: AAC33789.1. AC022234 Genomic DNA. No translation available. AC026166 Genomic DNA. No translation available. AC091492 Genomic DNA. No translation available.
UniGene	Hs.445503.
3D structure databases
ProteinModelPortal	Q92777.
SMR	Q92777. Positions 112-419.
ModBase	Search...
MobiDB	Search...
Protein-protein interaction databases
IntAct	Q92777. 1 interaction.
STRING	9606.ENSP00000342993.
PTM databases
PhosphoSite	Q92777.
Polymorphism databases
DMDM	223634710.
2D gel databases
UCD-2DPAGE	Q92777.
Proteomic databases
PaxDb	Q92777.
PRIDE	Q92777.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Organism-specific databases
GeneCards	GC03P012020.
HGNC	HGNC:11495. SYN2.
MIM	600755. gene.
neXtProt	NX_Q92777.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG284201.
HOVERGEN	HBG016354.
InParanoid	Q92777.
PhylomeDB	Q92777.
Enzyme and pathway databases
Reactome	REACT_13685. Neuronal System.
Gene expression databases
CleanEx	HS_SYN2.
Genevestigator	Q92777.
Family and domain databases
Gene3D	3.30.1490.20. 1 hit. 3.30.470.20. 2 hits. 3.40.50.20. 1 hit.
InterPro	IPR013815. ATP_grasp_subdomain_1. IPR013816. ATP_grasp_subdomain_2. IPR016185. PreATP-grasp_dom. IPR028710. Syn2. IPR001359. Synapsin. IPR020898. Synapsin_ATP-bd_dom. IPR019735. Synapsin_CS. IPR019736. Synapsin_P_site. IPR020897. Synapsin_pre-ATP-grasp_dom. [Graphical view]
PANTHER	PTHR10841:SF7. PTHR10841:SF7. 1 hit.
Pfam	PF02078. Synapsin. 1 hit. PF02750. Synapsin_C. 1 hit. PF10581. Synapsin_N. 1 hit. [Graphical view]
PRINTS	PR01368. SYNAPSIN.
SUPFAM	SSF52440. SSF52440. 1 hit.
PROSITE	PS00415. SYNAPSIN_1. 1 hit. PS00416. SYNAPSIN_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
PRO	Q92777.
SOURCE	Search...

Entry information

Entry name

SYN2_HUMAN

Accession

Primary (citable) accession number: Q92777
Secondary accession number(s): A8MY98

Entry history

Integrated into UniProtKB/Swiss-Prot:	May 30, 2000
Last sequence update:	February 10, 2009
Last modified:	April 16, 2014
This is version 111 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.