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Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei33ATPPROSITE-ProRule annotation1
Active sitei126Proton acceptorPROSITE-ProRule annotation1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi10 – 18ATPPROSITE-ProRule annotation9

GO - Molecular functioni

  • ATP binding Source: UniProtKB-KW
  • cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  • protein kinase activity Source: ProtInc

GO - Biological processi

  • positive regulation of protein targeting to mitochondrion Source: ParkinsonsUK-UCL
  • sex differentiation Source: ProtInc
  • signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:HS06554-MONOMER.
SignaLinkiQ92772.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Alternative name(s):
Protein kinase p56 KKIAMRE
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:CDKL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 4

Organism-specific databases

HGNCiHGNC:1782. CDKL2.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Nucleus 1 Publication

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi8999.
OpenTargetsiENSG00000138769.
PharmGKBiPA26318.

Chemistry databases

ChEMBLiCHEMBL5728.
GuidetoPHARMACOLOGYi1983.

Polymorphism and mutation databases

BioMutaiCDKL2.
DMDMi74762639.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000858141 – 493Cyclin-dependent kinase-like 2Add BLAST493

Proteomic databases

EPDiQ92772.
MaxQBiQ92772.
PaxDbiQ92772.
PeptideAtlasiQ92772.
PRIDEiQ92772.

PTM databases

iPTMnetiQ92772.
PhosphoSitePlusiQ92772.

Expressioni

Tissue specificityi

Expressed in testis and kidney, and at lower level in brain and lung.1 Publication

Gene expression databases

BgeeiENSG00000138769.
CleanExiHS_CDKL2.
ExpressionAtlasiQ92772. baseline and differential.
GenevisibleiQ92772. HS.

Organism-specific databases

HPAiHPA040672.

Interactioni

Protein-protein interaction databases

BioGridi114479. 7 interactors.
IntActiQ92772. 2 interactors.
STRINGi9606.ENSP00000412365.

Chemistry databases

BindingDBiQ92772.

Structurei

Secondary structure

1493
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Helixi1 – 3Combined sources3
Beta strandi4 – 9Combined sources6
Helixi10 – 13Combined sources4
Beta strandi16 – 23Combined sources8
Turni24 – 26Combined sources3
Beta strandi29 – 37Combined sources9
Helixi42 – 57Combined sources16
Beta strandi66 – 72Combined sources7
Beta strandi75 – 81Combined sources7
Beta strandi84 – 86Combined sources3
Helixi87 – 93Combined sources7
Helixi100 – 119Combined sources20
Helixi129 – 131Combined sources3
Beta strandi132 – 134Combined sources3
Beta strandi140 – 142Combined sources3
Helixi147 – 150Combined sources4
Helixi154 – 163Combined sources10
Helixi165 – 167Combined sources3
Helixi170 – 173Combined sources4
Helixi182 – 197Combined sources16
Helixi207 – 218Combined sources12
Helixi223 – 231Combined sources9
Helixi233 – 235Combined sources3
Helixi249 – 252Combined sources4
Helixi258 – 267Combined sources10
Helixi272 – 274Combined sources3
Helixi278 – 283Combined sources6
Helixi285 – 288Combined sources4
Helixi289 – 291Combined sources3
Helixi292 – 301Combined sources10

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AAAX-ray1.53A1-308[»]
4BBMX-ray2.00A/B1-308[»]
ProteinModelPortaliQ92772.
SMRiQ92772.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini4 – 287Protein kinasePROSITE-ProRule annotationAdd BLAST284

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi45 – 51[NKR]KIAxRE7

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOVERGENiHBG080204.
InParanoidiQ92772.
KOiK08824.
PhylomeDBiQ92772.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92772-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMFMGEP
210 220 230 240 250
LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL PEIKEREPLE
260 270 280 290 300
RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350
QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD
360 370 380 390 400
YKLFKIKGSK IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV
410 420 430 440 450
SVDHTRNPSV AIPPLTHNLS AVAPSINSGM GTETIPIQGY RVDEKTKKCS
460 470 480 490
IPFVKPNRHS PSGIYNINVT TLVSGPPLSD DSGADLPQME HQH
Length:493
Mass (Da):56,019
Last modified:February 1, 1997 - v1
Checksum:i5CC20A91CBF89EFE
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05392877Y → S.Corresponds to variant rs35921414dbSNPEnsembl.1
Natural variantiVAR_04198798L → I in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication1
Natural variantiVAR_053929132I → T.Corresponds to variant rs17000707dbSNPEnsembl.1
Natural variantiVAR_041988149R → Q in an ovarian mucinous carcinoma sample; somatic mutation. 1 PublicationCorresponds to variant rs755711267dbSNPEnsembl.1
Natural variantiVAR_041989197M → T.1 PublicationCorresponds to variant rs56343717dbSNPEnsembl.1
Natural variantiVAR_041990411A → V.1 PublicationCorresponds to variant rs56231363dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35146 mRNA. Translation: AAC50918.1.
AK312490 mRNA. Translation: BAG35392.1.
CH471057 Genomic DNA. Translation: EAX05740.1.
BC093646 mRNA. Translation: AAH93646.1.
BC093981 mRNA. Translation: AAH93981.1.
CCDSiCCDS3570.1.
RefSeqiNP_001317653.1. NM_001330724.1.
NP_003939.1. NM_003948.4.
XP_016864299.1. XM_017008810.1.
UniGeneiHs.591698.

Genome annotation databases

EnsembliENST00000429927; ENSP00000412365; ENSG00000138769.
GeneIDi8999.
KEGGihsa:8999.
UCSCiuc003hiq.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35146 mRNA. Translation: AAC50918.1.
AK312490 mRNA. Translation: BAG35392.1.
CH471057 Genomic DNA. Translation: EAX05740.1.
BC093646 mRNA. Translation: AAH93646.1.
BC093981 mRNA. Translation: AAH93981.1.
CCDSiCCDS3570.1.
RefSeqiNP_001317653.1. NM_001330724.1.
NP_003939.1. NM_003948.4.
XP_016864299.1. XM_017008810.1.
UniGeneiHs.591698.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
4AAAX-ray1.53A1-308[»]
4BBMX-ray2.00A/B1-308[»]
ProteinModelPortaliQ92772.
SMRiQ92772.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi114479. 7 interactors.
IntActiQ92772. 2 interactors.
STRINGi9606.ENSP00000412365.

Chemistry databases

BindingDBiQ92772.
ChEMBLiCHEMBL5728.
GuidetoPHARMACOLOGYi1983.

PTM databases

iPTMnetiQ92772.
PhosphoSitePlusiQ92772.

Polymorphism and mutation databases

BioMutaiCDKL2.
DMDMi74762639.

Proteomic databases

EPDiQ92772.
MaxQBiQ92772.
PaxDbiQ92772.
PeptideAtlasiQ92772.
PRIDEiQ92772.

Protocols and materials databases

DNASUi8999.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000429927; ENSP00000412365; ENSG00000138769.
GeneIDi8999.
KEGGihsa:8999.
UCSCiuc003hiq.4. human.

Organism-specific databases

CTDi8999.
DisGeNETi8999.
GeneCardsiCDKL2.
HGNCiHGNC:1782. CDKL2.
HPAiHPA040672.
MIMi603442. gene.
neXtProtiNX_Q92772.
OpenTargetsiENSG00000138769.
PharmGKBiPA26318.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0593. Eukaryota.
ENOG410XNSW. LUCA.
GeneTreeiENSGT00830000128262.
HOVERGENiHBG080204.
InParanoidiQ92772.
KOiK08824.
PhylomeDBiQ92772.
TreeFamiTF101031.

Enzyme and pathway databases

BioCyciZFISH:HS06554-MONOMER.
SignaLinkiQ92772.

Miscellaneous databases

ChiTaRSiCDKL2. human.
GeneWikiiCDKL2.
GenomeRNAii8999.
PROiQ92772.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000138769.
CleanExiHS_CDKL2.
ExpressionAtlasiQ92772. baseline and differential.
GenevisibleiQ92772. HS.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCDKL2_HUMAN
AccessioniPrimary (citable) accession number: Q92772
Secondary accession number(s): B2R695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 139 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.