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Q92772

- CDKL2_HUMAN

UniProt

Q92772 - CDKL2_HUMAN

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Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

Catalytic activityi

ATP + a protein = ADP + a phosphoprotein.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei33 – 331ATPPROSITE-ProRule annotation
Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. ATP binding Source: UniProtKB-KW
  2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
  3. protein kinase activity Source: ProtInc

GO - Biological processi

  1. sex differentiation Source: ProtInc
  2. signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Nucleotide-binding

Enzyme and pathway databases

SignaLinkiQ92772.

Names & Taxonomyi

Protein namesi
Recommended name:
Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
Alternative name(s):
Protein kinase p56 KKIAMRE
Serine/threonine-protein kinase KKIAMRE
Gene namesi
Name:CDKL2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 4

Organism-specific databases

HGNCiHGNC:1782. CDKL2.

Subcellular locationi

Cytoplasm 1 Publication. Nucleus 1 Publication

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB-KW
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA26318.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 493493Cyclin-dependent kinase-like 2PRO_0000085814Add
BLAST

Proteomic databases

PaxDbiQ92772.
PRIDEiQ92772.

PTM databases

PhosphoSiteiQ92772.

Expressioni

Tissue specificityi

Expressed in testis and kidney, and at lower level in brain and lung.1 Publication

Gene expression databases

BgeeiQ92772.
CleanExiHS_CDKL2.
ExpressionAtlasiQ92772. baseline and differential.
GenevestigatoriQ92772.

Organism-specific databases

HPAiHPA040672.

Interactioni

Protein-protein interaction databases

BioGridi114479. 7 interactions.
IntActiQ92772. 2 interactions.
STRINGi9606.ENSP00000306340.

Structurei

Secondary structure

493
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Helixi1 – 33Combined sources
Beta strandi4 – 96Combined sources
Helixi10 – 134Combined sources
Beta strandi16 – 238Combined sources
Turni24 – 263Combined sources
Beta strandi29 – 379Combined sources
Helixi42 – 5716Combined sources
Beta strandi66 – 727Combined sources
Beta strandi75 – 817Combined sources
Beta strandi84 – 863Combined sources
Helixi87 – 937Combined sources
Helixi100 – 11920Combined sources
Helixi129 – 1313Combined sources
Beta strandi132 – 1343Combined sources
Beta strandi140 – 1423Combined sources
Helixi147 – 1504Combined sources
Helixi154 – 16310Combined sources
Helixi165 – 1673Combined sources
Helixi170 – 1734Combined sources
Helixi182 – 19716Combined sources
Helixi207 – 21812Combined sources
Helixi223 – 2319Combined sources
Helixi233 – 2353Combined sources
Helixi249 – 2524Combined sources
Helixi258 – 26710Combined sources
Helixi272 – 2743Combined sources
Helixi278 – 2836Combined sources
Helixi285 – 2884Combined sources
Helixi289 – 2913Combined sources
Helixi292 – 30110Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
4AAAX-ray1.53A1-308[»]
4BBMX-ray2.00A/B1-308[»]
ProteinModelPortaliQ92772.
SMRiQ92772. Positions 1-403.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini4 – 287284Protein kinasePROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi45 – 517[NKR]KIAxRE

Domaini

The [NKR]KIAxRE motif seems to be a cyclin-binding region.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00760000119242.
HOVERGENiHBG080204.
InParanoidiQ92772.
KOiK08824.
PhylomeDBiQ92772.
TreeFamiTF101031.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view]
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SMARTiSM00220. S_TKc. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92772-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR
60 70 80 90 100
EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY
110 120 130 140 150
QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART
160 170 180 190 200
LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMFMGEP
210 220 230 240 250
LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL PEIKEREPLE
260 270 280 290 300
RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL
310 320 330 340 350
QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD
360 370 380 390 400
YKLFKIKGSK IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV
410 420 430 440 450
SVDHTRNPSV AIPPLTHNLS AVAPSINSGM GTETIPIQGY RVDEKTKKCS
460 470 480 490
IPFVKPNRHS PSGIYNINVT TLVSGPPLSD DSGADLPQME HQH
Length:493
Mass (Da):56,019
Last modified:February 1, 1997 - v1
Checksum:i5CC20A91CBF89EFE
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti77 – 771Y → S.
Corresponds to variant rs35921414 [ dbSNP | Ensembl ].
VAR_053928
Natural varianti98 – 981L → I in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication
VAR_041987
Natural varianti132 – 1321I → T.
Corresponds to variant rs17000707 [ dbSNP | Ensembl ].
VAR_053929
Natural varianti149 – 1491R → Q in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
VAR_041988
Natural varianti197 – 1971M → T.1 Publication
Corresponds to variant rs56343717 [ dbSNP | Ensembl ].
VAR_041989
Natural varianti411 – 4111A → V.1 Publication
Corresponds to variant rs56231363 [ dbSNP | Ensembl ].
VAR_041990

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35146 mRNA. Translation: AAC50918.1.
AK312490 mRNA. Translation: BAG35392.1.
CH471057 Genomic DNA. Translation: EAX05740.1.
BC093646 mRNA. Translation: AAH93646.1.
BC093981 mRNA. Translation: AAH93981.1.
CCDSiCCDS3570.1.
RefSeqiNP_003939.1. NM_003948.3.
UniGeneiHs.591698.

Genome annotation databases

EnsembliENST00000429927; ENSP00000412365; ENSG00000138769.
GeneIDi8999.
KEGGihsa:8999.
UCSCiuc003hiq.3. human.

Polymorphism databases

DMDMi74762639.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
U35146 mRNA. Translation: AAC50918.1 .
AK312490 mRNA. Translation: BAG35392.1 .
CH471057 Genomic DNA. Translation: EAX05740.1 .
BC093646 mRNA. Translation: AAH93646.1 .
BC093981 mRNA. Translation: AAH93981.1 .
CCDSi CCDS3570.1.
RefSeqi NP_003939.1. NM_003948.3.
UniGenei Hs.591698.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
Entry Method Resolution (Å) Chain Positions PDBsum
4AAA X-ray 1.53 A 1-308 [» ]
4BBM X-ray 2.00 A/B 1-308 [» ]
ProteinModelPortali Q92772.
SMRi Q92772. Positions 1-403.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 114479. 7 interactions.
IntActi Q92772. 2 interactions.
STRINGi 9606.ENSP00000306340.

Chemistry

BindingDBi Q92772.
ChEMBLi CHEMBL5728.
GuidetoPHARMACOLOGYi 1983.

PTM databases

PhosphoSitei Q92772.

Polymorphism databases

DMDMi 74762639.

Proteomic databases

PaxDbi Q92772.
PRIDEi Q92772.

Protocols and materials databases

DNASUi 8999.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000429927 ; ENSP00000412365 ; ENSG00000138769 .
GeneIDi 8999.
KEGGi hsa:8999.
UCSCi uc003hiq.3. human.

Organism-specific databases

CTDi 8999.
GeneCardsi GC04M076501.
HGNCi HGNC:1782. CDKL2.
HPAi HPA040672.
MIMi 603442. gene.
neXtProti NX_Q92772.
PharmGKBi PA26318.
GenAtlasi Search...

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00760000119242.
HOVERGENi HBG080204.
InParanoidi Q92772.
KOi K08824.
PhylomeDBi Q92772.
TreeFami TF101031.

Enzyme and pathway databases

SignaLinki Q92772.

Miscellaneous databases

ChiTaRSi CDKL2. human.
GeneWikii CDKL2.
GenomeRNAii 8999.
NextBioi 33747.
PROi Q92772.
SOURCEi Search...

Gene expression databases

Bgeei Q92772.
CleanExi HS_CDKL2.
ExpressionAtlasi Q92772. baseline and differential.
Genevestigatori Q92772.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR017441. Protein_kinase_ATP_BS.
IPR002290. Ser/Thr_dual-sp_kinase.
IPR008271. Ser/Thr_kinase_AS.
[Graphical view ]
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SMARTi SM00220. S_TKc. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
PS50011. PROTEIN_KINASE_DOM. 1 hit.
PS00108. PROTEIN_KINASE_ST. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE."
    Taglienti C.A., Wysk M., Davis R.J.
    Oncogene 13:2563-2574(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
    Tissue: Fetal brain.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Hippocampus.
  3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  5. "Patterns of somatic mutation in human cancer genomes."
    Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
    , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
    Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-98; GLN-149; THR-197 AND VAL-411.

Entry informationi

Entry nameiCDKL2_HUMAN
AccessioniPrimary (citable) accession number: Q92772
Secondary accession number(s): B2R695
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 22, 2005
Last sequence update: February 1, 1997
Last modified: November 26, 2014
This is version 121 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human chromosome 4
    Human chromosome 4: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  6. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  7. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3