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Q92772

- CDKL2_HUMAN

UniProt

Q92772 - CDKL2_HUMAN

Protein

Cyclin-dependent kinase-like 2

Gene

CDKL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 119 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    ATP + a protein = ADP + a phosphoprotein.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei33 – 331ATPPROSITE-ProRule annotation
    Active sitei126 – 1261Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi10 – 189ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. ATP binding Source: UniProtKB-KW
    2. cyclin-dependent protein serine/threonine kinase activity Source: UniProtKB-EC
    3. protein kinase activity Source: ProtInc

    GO - Biological processi

    1. sex differentiation Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Molecular functioni

    Kinase, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Nucleotide-binding

    Enzyme and pathway databases

    SignaLinkiQ92772.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cyclin-dependent kinase-like 2 (EC:2.7.11.22)
    Alternative name(s):
    Protein kinase p56 KKIAMRE
    Serine/threonine-protein kinase KKIAMRE
    Gene namesi
    Name:CDKL2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 4

    Organism-specific databases

    HGNCiHGNC:1782. CDKL2.

    Subcellular locationi

    Cytoplasm 1 Publication. Nucleus 1 Publication

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB-SubCell
    2. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA26318.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 493493Cyclin-dependent kinase-like 2PRO_0000085814Add
    BLAST

    Proteomic databases

    PaxDbiQ92772.
    PRIDEiQ92772.

    PTM databases

    PhosphoSiteiQ92772.

    Expressioni

    Tissue specificityi

    Expressed in testis and kidney, and at lower level in brain and lung.1 Publication

    Gene expression databases

    ArrayExpressiQ92772.
    BgeeiQ92772.
    CleanExiHS_CDKL2.
    GenevestigatoriQ92772.

    Organism-specific databases

    HPAiHPA040672.

    Interactioni

    Protein-protein interaction databases

    BioGridi114479. 3 interactions.
    IntActiQ92772. 2 interactions.
    STRINGi9606.ENSP00000306340.

    Structurei

    Secondary structure

    493
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi1 – 33
    Beta strandi4 – 96
    Helixi10 – 134
    Beta strandi16 – 238
    Turni24 – 263
    Beta strandi29 – 379
    Helixi42 – 5716
    Beta strandi66 – 727
    Beta strandi75 – 817
    Beta strandi84 – 863
    Helixi87 – 937
    Helixi100 – 11920
    Helixi129 – 1313
    Beta strandi132 – 1343
    Beta strandi140 – 1423
    Helixi147 – 1504
    Helixi154 – 16310
    Helixi165 – 1673
    Helixi170 – 1734
    Helixi182 – 19716
    Helixi207 – 21812
    Helixi223 – 2319
    Helixi233 – 2353
    Helixi249 – 2524
    Helixi258 – 26710
    Helixi272 – 2743
    Helixi278 – 2836
    Helixi285 – 2884
    Helixi289 – 2913
    Helixi292 – 30110

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    4AAAX-ray1.53A1-308[»]
    4BBMX-ray2.00A/B1-308[»]
    ProteinModelPortaliQ92772.
    SMRiQ92772. Positions 1-367.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini4 – 287284Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi45 – 517[NKR]KIAxRE

    Domaini

    The [NKR]KIAxRE motif seems to be a cyclin-binding region.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    HOVERGENiHBG080204.
    InParanoidiQ92772.
    KOiK08824.
    PhylomeDBiQ92772.
    TreeFamiTF101031.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view]
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SMARTiSM00220. S_TKc. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92772-1 [UniParc]FASTAAdd to Basket

    « Hide

    MEKYENLGLV GEGSYGMVMK CRNKDTGRIV AIKKFLESDD DKMVKKIAMR    50
    EIKLLKQLRH ENLVNLLEVC KKKKRWYLVF EFVDHTILDD LELFPNGLDY 100
    QVVQKYLFQI INGIGFCHSH NIIHRDIKPE NILVSQSGVV KLCDFGFART 150
    LAAPGEVYTD YVATRWYRAP ELLVGDVKYG KAVDVWAIGC LVTEMFMGEP 200
    LFPGDSDIDQ LYHIMMCLGN LIPRHQELFN KNPVFAGVRL PEIKEREPLE 250
    RRYPKLSEVV IDLAKKCLHI DPDKRPFCAE LLHHDFFQMD GFAERFSQEL 300
    QLKVQKDARN VSLSKKSQNR KKEKEKDDSL VEERKTLVVQ DTNADPKIKD 350
    YKLFKIKGSK IDGEKAEKGN RASNASCLHD SRTSHNKIVP STSLKDCSNV 400
    SVDHTRNPSV AIPPLTHNLS AVAPSINSGM GTETIPIQGY RVDEKTKKCS 450
    IPFVKPNRHS PSGIYNINVT TLVSGPPLSD DSGADLPQME HQH 493
    Length:493
    Mass (Da):56,019
    Last modified:February 1, 1997 - v1
    Checksum:i5CC20A91CBF89EFE
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti77 – 771Y → S.
    Corresponds to variant rs35921414 [ dbSNP | Ensembl ].
    VAR_053928
    Natural varianti98 – 981L → I in an ovarian papillary serous adenocarcinoma sample; somatic mutation. 1 Publication
    VAR_041987
    Natural varianti132 – 1321I → T.
    Corresponds to variant rs17000707 [ dbSNP | Ensembl ].
    VAR_053929
    Natural varianti149 – 1491R → Q in an ovarian mucinous carcinoma sample; somatic mutation. 1 Publication
    VAR_041988
    Natural varianti197 – 1971M → T.1 Publication
    Corresponds to variant rs56343717 [ dbSNP | Ensembl ].
    VAR_041989
    Natural varianti411 – 4111A → V.1 Publication
    Corresponds to variant rs56231363 [ dbSNP | Ensembl ].
    VAR_041990

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35146 mRNA. Translation: AAC50918.1.
    AK312490 mRNA. Translation: BAG35392.1.
    CH471057 Genomic DNA. Translation: EAX05740.1.
    BC093646 mRNA. Translation: AAH93646.1.
    BC093981 mRNA. Translation: AAH93981.1.
    CCDSiCCDS3570.1.
    RefSeqiNP_003939.1. NM_003948.3.
    UniGeneiHs.591698.

    Genome annotation databases

    EnsembliENST00000429927; ENSP00000412365; ENSG00000138769.
    GeneIDi8999.
    KEGGihsa:8999.
    UCSCiuc003hiq.3. human.

    Polymorphism databases

    DMDMi74762639.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    U35146 mRNA. Translation: AAC50918.1 .
    AK312490 mRNA. Translation: BAG35392.1 .
    CH471057 Genomic DNA. Translation: EAX05740.1 .
    BC093646 mRNA. Translation: AAH93646.1 .
    BC093981 mRNA. Translation: AAH93981.1 .
    CCDSi CCDS3570.1.
    RefSeqi NP_003939.1. NM_003948.3.
    UniGenei Hs.591698.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    4AAA X-ray 1.53 A 1-308 [» ]
    4BBM X-ray 2.00 A/B 1-308 [» ]
    ProteinModelPortali Q92772.
    SMRi Q92772. Positions 1-367.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 114479. 3 interactions.
    IntActi Q92772. 2 interactions.
    STRINGi 9606.ENSP00000306340.

    Chemistry

    BindingDBi Q92772.
    ChEMBLi CHEMBL5728.
    GuidetoPHARMACOLOGYi 1983.

    PTM databases

    PhosphoSitei Q92772.

    Polymorphism databases

    DMDMi 74762639.

    Proteomic databases

    PaxDbi Q92772.
    PRIDEi Q92772.

    Protocols and materials databases

    DNASUi 8999.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000429927 ; ENSP00000412365 ; ENSG00000138769 .
    GeneIDi 8999.
    KEGGi hsa:8999.
    UCSCi uc003hiq.3. human.

    Organism-specific databases

    CTDi 8999.
    GeneCardsi GC04M076501.
    HGNCi HGNC:1782. CDKL2.
    HPAi HPA040672.
    MIMi 603442. gene.
    neXtProti NX_Q92772.
    PharmGKBi PA26318.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG0515.
    HOVERGENi HBG080204.
    InParanoidi Q92772.
    KOi K08824.
    PhylomeDBi Q92772.
    TreeFami TF101031.

    Enzyme and pathway databases

    SignaLinki Q92772.

    Miscellaneous databases

    ChiTaRSi CDKL2. human.
    GeneWikii CDKL2.
    GenomeRNAii 8999.
    NextBioi 33747.
    PROi Q92772.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92772.
    Bgeei Q92772.
    CleanExi HS_CDKL2.
    Genevestigatori Q92772.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR017441. Protein_kinase_ATP_BS.
    IPR002290. Ser/Thr_dual-sp_kinase_dom.
    IPR008271. Ser/Thr_kinase_AS.
    [Graphical view ]
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SMARTi SM00220. S_TKc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS00107. PROTEIN_KINASE_ATP. 1 hit.
    PS50011. PROTEIN_KINASE_DOM. 1 hit.
    PS00108. PROTEIN_KINASE_ST. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the epidermal growth factor-stimulated protein kinase p56 KKIAMRE."
      Taglienti C.A., Wysk M., Davis R.J.
      Oncogene 13:2563-2574(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, SUBCELLULAR LOCATION.
      Tissue: Fetal brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Hippocampus.
    3. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    5. "Patterns of somatic mutation in human cancer genomes."
      Greenman C., Stephens P., Smith R., Dalgliesh G.L., Hunter C., Bignell G., Davies H., Teague J., Butler A., Stevens C., Edkins S., O'Meara S., Vastrik I., Schmidt E.E., Avis T., Barthorpe S., Bhamra G., Buck G.
      , Choudhury B., Clements J., Cole J., Dicks E., Forbes S., Gray K., Halliday K., Harrison R., Hills K., Hinton J., Jenkinson A., Jones D., Menzies A., Mironenko T., Perry J., Raine K., Richardson D., Shepherd R., Small A., Tofts C., Varian J., Webb T., West S., Widaa S., Yates A., Cahill D.P., Louis D.N., Goldstraw P., Nicholson A.G., Brasseur F., Looijenga L., Weber B.L., Chiew Y.-E., DeFazio A., Greaves M.F., Green A.R., Campbell P., Birney E., Easton D.F., Chenevix-Trench G., Tan M.-H., Khoo S.K., Teh B.T., Yuen S.T., Leung S.Y., Wooster R., Futreal P.A., Stratton M.R.
      Nature 446:153-158(2007) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANTS [LARGE SCALE ANALYSIS] ILE-98; GLN-149; THR-197 AND VAL-411.

    Entry informationi

    Entry nameiCDKL2_HUMAN
    AccessioniPrimary (citable) accession number: Q92772
    Secondary accession number(s): B2R695
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 22, 2005
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 119 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human chromosome 4
      Human chromosome 4: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    6. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    7. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3