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Protein

Putative ATP-dependent RNA helicase DDX12

Gene

DDX12P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Protein uncertaini

Functioni

DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 70ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Cell cycle

Keywords - Ligandi

ATP-binding, DNA-binding, Nucleotide-binding, RNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111788-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DDX12 (EC:3.6.4.13)
Alternative name(s):
CHL1-related protein 2
Short name:
hCHLR2
DEAD/H box protein 12
Gene namesi
Name:DDX12P
Synonyms:CHLR2, DDX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2737. DDX12P.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi182705254.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078151 – 950Putative ATP-dependent RNA helicase DDX12Add BLAST950

Proteomic databases

EPDiQ92771.
MaxQBiQ92771.
PaxDbiQ92771.
PeptideAtlasiQ92771.
PRIDEiQ92771.

PTM databases

iPTMnetiQ92771.
PhosphoSitePlusiQ92771.

Expressioni

Tissue specificityi

Only expressed in proliferating tissues.1 Publication

Gene expression databases

CleanExiHS_DDX12.

Organism-specific databases

HPAiHPA047228.
HPA065197.

Interactioni

Protein-protein interaction databases

STRINGi9606.ENSP00000384703.

Structurei

3D structure databases

ProteinModelPortaliQ92771.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 464Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST437

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi412 – 415DEAH4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 243Glu-richAdd BLAST62

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG1133. Eukaryota.
COG1199. LUCA.
HOGENOMiHOG000241266.
HOVERGENiHBG058884.
InParanoidiQ92771.
PhylomeDBiQ92771.

Family and domain databases

InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGGGCSGS LSLRGPASFK FSGVCPDSRG LAFSVAILPA KKEDFMAELY
60 70 80 90 100
RVLEAGKIGI FESPTGTGKS LSLICGALSW LRDFEQKKRE EEARLLETGT
110 120 130 140 150
GPLHDEKDES LCLSSSCEGA AGTPRPAGEP AWVTQFVQKK EERDLVNRLK
160 170 180 190 200
AEQARRKQRE ERLQQLQHRV QLKYAAKRLR QEEEERENLL RLSREMLETG
210 220 230 240 250
PEAERPEQLE SGEEELVLAE YESDEEKKVA SGVDEDEDDL EEEHITKIYH
260 270 280 290 300
CSRTHSQLAQ FVHEVKKSPF GKDVRLVSLG SRQNLCVNED VRSLGSVQLI
310 320 330 340 350
NNRCVDMQRS RHEKKKGAEE EKPKRRRQEK QAACPFYNHE QMGLLRDEAL
360 370 380 390 400
AEVKDMEQLL ALGKEARACP YYGSRLAIPA AQLVVLPYQM LLHAATRQAA
410 420 430 440 450
GIRLQDQVVI IDEAHNLIDT TTSMHSVEVS GSQLCQAHSQ LLQYMERYGK
460 470 480 490 500
RLKAKNLMYL KQILYLLEKF VAVLGGNIKQ NPNTQSLSQT GMELKTINDF
510 520 530 540 550
LFQSQIDNIN LFKVQRYCEK SMISRKLFGF TERYGAVFSS REQPKLAGFQ
560 570 580 590 600
QFLQSLQPRT TEALAAPADE SQASVPQPAS PLMHIEGFLA ALTTANQDGR
610 620 630 640 650
VILSRQGSLS QSTLKFLLLN PAVHFAQVVK ECRAVVIAGG TMQPVSNFRQ
660 670 680 690 700
QLLACAGVEA ERVVEFSCGH VIPPDNILPL VICSGVSNQP LEFTFQKRDL
710 720 730 740 750
PQMMDEVGRI LCNLCGVVSG GVVCFFPSYE YLRQVHAHWE KGGLLGRLAA
760 770 780 790 800
RKKIFQEPKS AHQVEQVLLA YSRCLQACGQ ERGPVTGALL LSVVGGKMSE
810 820 830 840 850
GINFSDNLGR CVVMVGMPFP NIRSAELQEK MAYLDQTLPR APGQAHPGKA
860 870 880 890 900
LVENLCMKAV NQSIGRAIRH QKDFASIVLL DQRYARPPVL AKLPAWIRAR
910 920 930 940 950
VEVKATFGPA IAAVQKVSPT FFFLRASQPR DHISHCLLSA QFHREKSASS
Length:950
Mass (Da):106,006
Last modified:December 4, 2007 - v3
Checksum:iEE9417A878ACAE85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205 – 206RP → WL in AAB06963 (PubMed:9013641).Curated2
Sequence conflicti250H → Y in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti282R → Q in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti302N → D in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti373G → R in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti387P → S in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti421 – 423TTS → ITG in AAB06963 (PubMed:9013641).Curated3
Sequence conflicti647N → D in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti684S → I in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti716G → S in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti747R → H in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti775L → I in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti846H → P in AAB06963 (PubMed:9013641).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092821 Genomic DNA. No translation available.
AC141557 Genomic DNA. No translation available.
U33834 mRNA. Translation: AAB06963.1.
UniGeneiHs.447869.
Hs.504688.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092821 Genomic DNA. No translation available.
AC141557 Genomic DNA. No translation available.
U33834 mRNA. Translation: AAB06963.1.
UniGeneiHs.447869.
Hs.504688.

3D structure databases

ProteinModelPortaliQ92771.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi9606.ENSP00000384703.

PTM databases

iPTMnetiQ92771.
PhosphoSitePlusiQ92771.

Polymorphism and mutation databases

DMDMi182705254.

Proteomic databases

EPDiQ92771.
MaxQBiQ92771.
PaxDbiQ92771.
PeptideAtlasiQ92771.
PRIDEiQ92771.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

GeneCardsiDDX12P.
HGNCiHGNC:2737. DDX12P.
HPAiHPA047228.
HPA065197.
MIMi601151. gene.
neXtProtiNX_Q92771.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1133. Eukaryota.
COG1199. LUCA.
HOGENOMiHOG000241266.
HOVERGENiHBG058884.
InParanoidiQ92771.
PhylomeDBiQ92771.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000111788-MONOMER.

Miscellaneous databases

SOURCEiSearch...

Gene expression databases

CleanExiHS_DDX12.

Family and domain databases

InterProiIPR006555. ATP-dep_Helicase_C.
IPR010614. DEAD_2.
IPR013020. DNA_helicase_DNA-repair_Rad3.
IPR014013. Helic_SF1/SF2_ATP-bd_DinG/Rad3.
IPR006554. Helicase-like_DEXD_c2.
IPR027417. P-loop_NTPase.
[Graphical view]
PfamiPF06733. DEAD_2. 1 hit.
PF13307. Helicase_C_2. 1 hit.
[Graphical view]
SMARTiSM00488. DEXDc2. 1 hit.
SM00491. HELICc2. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 3 hits.
TIGRFAMsiTIGR00604. rad3. 1 hit.
PROSITEiPS51193. HELICASE_ATP_BIND_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX12_HUMAN
AccessioniPrimary (citable) accession number: Q92771
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 4, 2007
Last modified: November 2, 2016
This is version 118 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Caution

Could be the product of a pseudogene.Curated

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 12
    Human chromosome 12: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.