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Protein

Putative ATP-dependent RNA helicase DDX12

Gene

DDX12P

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Protein uncertaini

Functioni

DNA helicase involved in cellular proliferation. Probably required for maintaining the chromosome segregation (By similarity).By similarity

Caution

Could be the product of a pseudogene.Curated

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi63 – 70ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionDNA-binding, Helicase, Hydrolase, RNA-binding
Biological processCell cycle
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Putative ATP-dependent RNA helicase DDX12 (EC:3.6.4.13)
Alternative name(s):
CHL1-related protein 2
Short name:
hCHLR2
DEAD/H box protein 12
Gene namesi
Name:DDX12P
Synonyms:CHLR2, DDX12
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Unplaced

Organism-specific databases

HGNCiHGNC:2737 DDX12P
MIMi601151 gene
neXtProtiNX_Q92771

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Polymorphism and mutation databases

DMDMi182705254

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003078151 – 950Putative ATP-dependent RNA helicase DDX12Add BLAST950

Proteomic databases

EPDiQ92771
MaxQBiQ92771
PeptideAtlasiQ92771
PRIDEiQ92771

PTM databases

iPTMnetiQ92771
PhosphoSitePlusiQ92771

Expressioni

Tissue specificityi

Only expressed in proliferating tissues.1 Publication

Gene expression databases

CleanExiHS_DDX12

Organism-specific databases

HPAiHPA065197

Structurei

3D structure databases

ProteinModelPortaliQ92771
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini28 – 464Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST437

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi412 – 415DEAH4

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi182 – 243Glu-richAdd BLAST62

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG1133 Eukaryota
COG1199 LUCA
HOGENOMiHOG000241266
HOVERGENiHBG058884
InParanoidiQ92771
PhylomeDBiQ92771

Family and domain databases

InterProiView protein in InterPro
IPR006555 ATP-dep_Helicase_C
IPR028331 DDX11/DDX12
IPR010614 DEAD_2
IPR014013 Helic_SF1/SF2_ATP-bd_DinG/Rad3
IPR006554 Helicase-like_DEXD_c2
IPR027417 P-loop_NTPase
IPR013020 Rad3/Chl1-like
PANTHERiPTHR11472:SF55 PTHR11472:SF55, 1 hit
PfamiView protein in Pfam
PF06733 DEAD_2, 1 hit
PF13307 Helicase_C_2, 1 hit
SMARTiView protein in SMART
SM00488 DEXDc2, 1 hit
SM00491 HELICc2, 1 hit
SUPFAMiSSF52540 SSF52540, 3 hits
TIGRFAMsiTIGR00604 rad3, 1 hit
PROSITEiView protein in PROSITE
PS51193 HELICASE_ATP_BIND_2, 1 hit

Sequencei

Sequence statusi: Complete.

Q92771-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRSGGGCSGS LSLRGPASFK FSGVCPDSRG LAFSVAILPA KKEDFMAELY
60 70 80 90 100
RVLEAGKIGI FESPTGTGKS LSLICGALSW LRDFEQKKRE EEARLLETGT
110 120 130 140 150
GPLHDEKDES LCLSSSCEGA AGTPRPAGEP AWVTQFVQKK EERDLVNRLK
160 170 180 190 200
AEQARRKQRE ERLQQLQHRV QLKYAAKRLR QEEEERENLL RLSREMLETG
210 220 230 240 250
PEAERPEQLE SGEEELVLAE YESDEEKKVA SGVDEDEDDL EEEHITKIYH
260 270 280 290 300
CSRTHSQLAQ FVHEVKKSPF GKDVRLVSLG SRQNLCVNED VRSLGSVQLI
310 320 330 340 350
NNRCVDMQRS RHEKKKGAEE EKPKRRRQEK QAACPFYNHE QMGLLRDEAL
360 370 380 390 400
AEVKDMEQLL ALGKEARACP YYGSRLAIPA AQLVVLPYQM LLHAATRQAA
410 420 430 440 450
GIRLQDQVVI IDEAHNLIDT TTSMHSVEVS GSQLCQAHSQ LLQYMERYGK
460 470 480 490 500
RLKAKNLMYL KQILYLLEKF VAVLGGNIKQ NPNTQSLSQT GMELKTINDF
510 520 530 540 550
LFQSQIDNIN LFKVQRYCEK SMISRKLFGF TERYGAVFSS REQPKLAGFQ
560 570 580 590 600
QFLQSLQPRT TEALAAPADE SQASVPQPAS PLMHIEGFLA ALTTANQDGR
610 620 630 640 650
VILSRQGSLS QSTLKFLLLN PAVHFAQVVK ECRAVVIAGG TMQPVSNFRQ
660 670 680 690 700
QLLACAGVEA ERVVEFSCGH VIPPDNILPL VICSGVSNQP LEFTFQKRDL
710 720 730 740 750
PQMMDEVGRI LCNLCGVVSG GVVCFFPSYE YLRQVHAHWE KGGLLGRLAA
760 770 780 790 800
RKKIFQEPKS AHQVEQVLLA YSRCLQACGQ ERGPVTGALL LSVVGGKMSE
810 820 830 840 850
GINFSDNLGR CVVMVGMPFP NIRSAELQEK MAYLDQTLPR APGQAHPGKA
860 870 880 890 900
LVENLCMKAV NQSIGRAIRH QKDFASIVLL DQRYARPPVL AKLPAWIRAR
910 920 930 940 950
VEVKATFGPA IAAVQKVSPT FFFLRASQPR DHISHCLLSA QFHREKSASS
Length:950
Mass (Da):106,006
Last modified:December 4, 2007 - v3
Checksum:iEE9417A878ACAE85
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti205 – 206RP → WL in AAB06963 (PubMed:9013641).Curated2
Sequence conflicti250H → Y in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti282R → Q in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti302N → D in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti373G → R in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti387P → S in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti421 – 423TTS → ITG in AAB06963 (PubMed:9013641).Curated3
Sequence conflicti647N → D in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti684S → I in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti716G → S in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti747R → H in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti775L → I in AAB06963 (PubMed:9013641).Curated1
Sequence conflicti846H → P in AAB06963 (PubMed:9013641).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC092821 Genomic DNA No translation available.
AC141557 Genomic DNA No translation available.
U33834 mRNA Translation: AAB06963.1
UniGeneiHs.447869
Hs.504688

Similar proteinsi

Entry informationi

Entry nameiDDX12_HUMAN
AccessioniPrimary (citable) accession number: Q92771
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 23, 2007
Last sequence update: December 4, 2007
Last modified: March 28, 2018
This is version 125 of the entry and version 3 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
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Main funding by: National Institutes of Health