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Q92764

- KRT35_HUMAN

UniProt

Q92764 - KRT35_HUMAN

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Protein

Keratin, type I cuticular Ha5

Gene

KRT35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei346 – 3461Stutter

GO - Molecular functioni

  1. structural molecule activity Source: InterPro

GO - Biological processi

  1. anatomical structure morphogenesis Source: ProtInc
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha5
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name:
K35
Gene namesi
Name:KRT35
Synonyms:HHA5, HKA5, KRTHA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 17

Organism-specific databases

HGNCiHGNC:6453. KRT35.

Subcellular locationi

GO - Cellular componenti

  1. extracellular space Source: UniProt
  2. extracellular vesicular exosome Source: UniProtKB
  3. intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA30242.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 455455Keratin, type I cuticular Ha5PRO_0000063692Add
BLAST

Proteomic databases

MaxQBiQ92764.
PaxDbiQ92764.
PRIDEiQ92764.

PTM databases

PhosphoSiteiQ92764.

Expressioni

Tissue specificityi

Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.1 Publication

Gene expression databases

BgeeiQ92764.
CleanExiHS_KRT35.
ExpressionAtlasiQ92764. differential.
GenevestigatoriQ92764.

Interactioni

Protein-protein interaction databases

BioGridi110084. 6 interactions.
IntActiQ92764. 3 interactions.
STRINGi9606.ENSP00000377558.

Structurei

3D structure databases

ProteinModelPortaliQ92764.
SMRiQ92764. Positions 147-245, 315-402.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1 – 9797HeadAdd
BLAST
Regioni98 – 404307RodAdd
BLAST
Regioni98 – 13235Coil 1AAdd
BLAST
Regioni133 – 14311Linker 1Add
BLAST
Regioni144 – 244101Coil 1BAdd
BLAST
Regioni245 – 26016Linker 12Add
BLAST
Regioni261 – 404144Coil 2Add
BLAST
Regioni405 – 45551TailAdd
BLAST

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi33 – 364Poly-Ser
Compositional biasi83 – 864Poly-Gly

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG145287.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ92764.
KOiK07604.
OMAiARSFSAC.
OrthoDBiEOG7FV3Q8.
PhylomeDBiQ92764.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92764 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS
60 70 80 90 100
ACSVGLGRSS YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAG YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
IEELQKKTLC SKAENARLVV EIDNAKLAAD DFRTKYETEV SLRQLVESDI
210 220 230 240 250
NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV
310 320 330 340 350
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS
360 370 380 390 400
QLAQMQCMIT NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSPS KSCLPCLPAA SCGPSAARTN CSPRPICVPC

PGGRF
Length:455
Mass (Da):50,361
Last modified:May 18, 2010 - v5
Checksum:i3E72080469C8E80B
GO

Sequence cautioni

The sequence CAA62286.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
The sequence CAA76387.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti117 – 1182QL → HV in CAA62286. (PubMed:8823373)Curated
Sequence conflicti117 – 1182QL → HV in CAA76387. (PubMed:9756910)Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti36 – 361S → P.1 Publication
Corresponds to variant rs743686 [ dbSNP | Ensembl ].
VAR_056019
Natural varianti441 – 4411C → Y.
Corresponds to variant rs12451652 [ dbSNP | Ensembl ].
VAR_056020
Natural varianti443 – 4431P → A.1 Publication
Corresponds to variant rs2071601 [ dbSNP | Ensembl ].
VAR_056021

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90762 Genomic DNA. Translation: CAA62285.1.
X90763 mRNA. Translation: CAA62286.1. Different initiation.
Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
AC019349 Genomic DNA. No translation available.
CCDSiCCDS11394.2.
RefSeqiNP_002271.3. NM_002280.4.
UniGeneiHs.73082.

Genome annotation databases

EnsembliENST00000393989; ENSP00000377558; ENSG00000197079.
GeneIDi3886.
KEGGihsa:3886.
UCSCiuc002hws.3. human.

Polymorphism databases

DMDMi296439499.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
X90762 Genomic DNA. Translation: CAA62285.1 .
X90763 mRNA. Translation: CAA62286.1 . Different initiation.
Y16791 Genomic DNA. Translation: CAA76387.1 . Different initiation.
AC019349 Genomic DNA. No translation available.
CCDSi CCDS11394.2.
RefSeqi NP_002271.3. NM_002280.4.
UniGenei Hs.73082.

3D structure databases

ProteinModelPortali Q92764.
SMRi Q92764. Positions 147-245, 315-402.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 110084. 6 interactions.
IntActi Q92764. 3 interactions.
STRINGi 9606.ENSP00000377558.

PTM databases

PhosphoSitei Q92764.

Polymorphism databases

DMDMi 296439499.

Proteomic databases

MaxQBi Q92764.
PaxDbi Q92764.
PRIDEi Q92764.

Protocols and materials databases

DNASUi 3886.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000393989 ; ENSP00000377558 ; ENSG00000197079 .
GeneIDi 3886.
KEGGi hsa:3886.
UCSCi uc002hws.3. human.

Organism-specific databases

CTDi 3886.
GeneCardsi GC17M039632.
H-InvDB HIX0039250.
HGNCi HGNC:6453. KRT35.
MIMi 602764. gene.
neXtProti NX_Q92764.
PharmGKBi PA30242.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG145287.
GeneTreei ENSGT00760000118808.
HOGENOMi HOG000230975.
HOVERGENi HBG013015.
InParanoidi Q92764.
KOi K07604.
OMAi ARSFSAC.
OrthoDBi EOG7FV3Q8.
PhylomeDBi Q92764.
TreeFami TF332742.

Miscellaneous databases

ChiTaRSi KRT35. human.
GenomeRNAii 3886.
NextBioi 15255.
PROi Q92764.
SOURCEi Search...

Gene expression databases

Bgeei Q92764.
CleanExi HS_KRT35.
ExpressionAtlasi Q92764. differential.
Genevestigatori Q92764.

Family and domain databases

InterProi IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view ]
PANTHERi PTHR23239. PTHR23239. 1 hit.
Pfami PF00038. Filament. 1 hit.
[Graphical view ]
PRINTSi PR01248. TYPE1KERATIN.
SUPFAMi SSF46579. SSF46579. 1 hit.
PROSITEi PS00226. IF. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5."
    Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.
    J. Invest. Dermatol. 107:633-638(1996) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455, TISSUE SPECIFICITY, VARIANTS PRO-36 AND ALA-443.
    Tissue: Hair and Scalp.
  2. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
    Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
    J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
  3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
    Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
    , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
    Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiKRT35_HUMAN
AccessioniPrimary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: October 29, 2014
This is version 115 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3