Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q92764 (KRT35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 113. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Keratin, type I cuticular Ha5
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name=K35
Gene names
Name:KRT35
Synonyms:HHA5, HKA5, KRTHA5
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Tissue specificity

Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb. Ref.1

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Sequence caution

The sequence CAA62286.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

The sequence CAA76387.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanatomical structure morphogenesis

Traceable author statement Ref.1. Source: ProtInc

   Cellular_componentextracellular space

Inferred from direct assay PubMed 23580065. Source: UniProt

intermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular_functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Keratin, type I cuticular Ha5
PRO_0000063692

Regions

Region1 – 9797Head
Region98 – 404307Rod
Region98 – 13235Coil 1A
Region133 – 14311Linker 1
Region144 – 244101Coil 1B
Region245 – 26016Linker 12
Region261 – 404144Coil 2
Region405 – 45551Tail
Compositional bias33 – 364Poly-Ser
Compositional bias83 – 864Poly-Gly

Sites

Site3461Stutter

Natural variations

Natural variant361S → P. Ref.1
Corresponds to variant rs743686 [ dbSNP | Ensembl ].
VAR_056019
Natural variant4411C → Y.
Corresponds to variant rs12451652 [ dbSNP | Ensembl ].
VAR_056020
Natural variant4431P → A. Ref.1
Corresponds to variant rs2071601 [ dbSNP | Ensembl ].
VAR_056021

Experimental info

Sequence conflict117 – 1182QL → HV in CAA62286. Ref.1
Sequence conflict117 – 1182QL → HV in CAA76387. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q92764 [UniParc].

Last modified May 18, 2010. Version 5.
Checksum: 3E72080469C8E80B

FASTA45550,361
        10         20         30         40         50         60 
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS 

        70         80         90        100        110        120 
YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRQLEQ 

       130        140        150        160        170        180 
ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD 

       190        200        210        220        230        240 
DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN 

       250        260        270        280        290        300 
SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV 

       310        320        330        340        350        360 
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT 

       370        380        390        400        410        420 
NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS 

       430        440        450 
KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF 

« Hide

References

« Hide 'large scale' references
[1]"Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5."
Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.
J. Invest. Dermatol. 107:633-638(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455, TISSUE SPECIFICITY, VARIANTS PRO-36 AND ALA-443.
Tissue: Hair and Scalp.
[2]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. expand/collapse author list , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
X90762 Genomic DNA. Translation: CAA62285.1.
X90763 mRNA. Translation: CAA62286.1. Different initiation.
Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
AC019349 Genomic DNA. No translation available.
CCDSCCDS11394.2.
RefSeqNP_002271.3. NM_002280.4.
UniGeneHs.73082.

3D structure databases

ProteinModelPortalQ92764.
SMRQ92764. Positions 99-130, 147-245, 315-402.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110084. 6 interactions.
IntActQ92764. 3 interactions.
STRING9606.ENSP00000377558.

PTM databases

PhosphoSiteQ92764.

Polymorphism databases

DMDM296439499.

Proteomic databases

MaxQBQ92764.
PaxDbQ92764.
PRIDEQ92764.

Protocols and materials databases

DNASU3886.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000393989; ENSP00000377558; ENSG00000197079.
GeneID3886.
KEGGhsa:3886.
UCSCuc002hws.3. human.

Organism-specific databases

CTD3886.
GeneCardsGC17M039632.
H-InvDBHIX0039250.
HGNCHGNC:6453. KRT35.
MIM602764. gene.
neXtProtNX_Q92764.
PharmGKBPA30242.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG145287.
HOGENOMHOG000230975.
HOVERGENHBG013015.
InParanoidQ92764.
KOK07604.
OMAARSFSAC.
OrthoDBEOG7FV3Q8.
PhylomeDBQ92764.
TreeFamTF332742.

Gene expression databases

ArrayExpressQ92764.
BgeeQ92764.
CleanExHS_KRT35.
GenevestigatorQ92764.

Family and domain databases

InterProIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERPTHR23239. PTHR23239. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
SUPFAMSSF46579. SSF46579. 1 hit.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

ChiTaRSKRT35. human.
GenomeRNAi3886.
NextBio15255.
PROQ92764.
SOURCESearch...

Entry information

Entry nameKRT35_HUMAN
AccessionPrimary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: July 9, 2014
This is version 113 of the entry and version 5 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM