Reviewed, UniProtKB/Swiss-Prot Q92764 (KRT35_HUMAN)

Names and origin

Protein names

Recommended name:
    Keratin, type I cuticular Ha5
Alternative name(s):
    Hair keratin, type I Ha5
    Keratin-35
      Short name=K35

Gene names

Name:	KRT35
Synonyms:	HHA5, HKA5, KRTHA5

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Tissue specificity	Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb. Ref.1
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	anatomical structure morphogenesis Ref.1 Traceable author statement. Source: ProtInc
Cellular component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Keratin, type I cuticular Ha5		PRO_0000063692
Regions
	Region	1 – 97	97	Head
	Region	98 – 404	307	Rod
	Region	98 – 132	35	Coil 1A
	Region	133 – 143	11	Linker 1
	Region	144 – 244	101	Coil 1B
	Region	245 – 260	16	Linker 12
	Region	261 – 404	144	Coil 2
	Region	405 – 455	51	Tail
	Compositional bias	33 – 36	4	Poly-Ser
	Compositional bias	83 – 86	4	Poly-Gly
Sites
	Site	346	1	Stutter
Natural variations
	Natural variant	36	1	S → P: dbSNP rs743686.		VAR_056019
	Natural variant	441	1	C → Y: dbSNP rs12451652.		VAR_056020
	Natural variant	443	1	P → A: dbSNP rs2071601.		VAR_056021

Sequences

	Sequence		Length	Mass (Da)
	Q92764-1 [UniParc]. Last modified January 20, 2009. Version 4. Checksum: 84B96F94FAD21D2C	FASTA	455	50,356
	10 20 30 40 50 60 MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS 70 80 90 100 110 120 YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRHVEQ 130 140 150 160 170 180 ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD 190 200 210 220 230 240 DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN 250 260 270 280 290 300 SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV 310 320 330 340 350 360 SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT 370 380 390 400 410 420 NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS 430 440 450 KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF

References

[1]	"Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5." Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J. J. Invest. Dermatol. 107:633-638(1996) [PubMed: 8823373] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455, TISSUE SPECIFICITY, VARIANTS PRO-36 AND ALA-443. Tissue: Hair and Scalp.
[2]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	X90762 Genomic DNA. Translation: CAA62285.1. X90763 mRNA. Translation: CAA62286.1. Different initiation. Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
IPI	IPI00790172.
RefSeq	NP_002271.3.
UniGene	Hs.73082
3D structure databases
HSSP	HSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBase	Search...
PTM databases
PhosphoSite	Q92764.
Genome annotation databases
Ensembl	ENSG00000197079. Homo sapiens. [Contig view]
GeneID	3886.
KEGG	hsa:3886.
UCSC	uc002hws.1. human.
Organism-specific databases
GeneCards	GC17M036887.
H-InvDB	HIX0039250.
HGNC	HGNC:6453. KRT35.
MIM	602764. gene.
PharmGKB	PA30242.
GenAtlas	Search...
Phylogenomic databases
HOGENOM	Q92764.
HOVERGEN	Q92764.
Gene expression databases
ArrayExpress	Q92764.
Bgee	Q92764.
CleanEx	HS_KRT35.
GermOnline	ENSG00000197079. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. IF. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	15255.
SOURCE	Search...

Entry information

Entry name

KRT35_HUMAN

Accession

Primary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	January 20, 2009
Last modified:	July 7, 2009
This is version 69 of the entry and version 4 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)