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Q92764

- KRT35_HUMAN

UniProt

Q92764 - KRT35_HUMAN

Protein

Keratin, type I cuticular Ha5

Gene

KRT35

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 114 (01 Oct 2014)
      Sequence version 5 (18 May 2010)
      Previous versions | rss
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    Functioni

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei346 – 3461Stutter

    GO - Molecular functioni

    1. structural molecule activity Source: InterPro

    GO - Biological processi

    1. anatomical structure morphogenesis Source: ProtInc

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Keratin, type I cuticular Ha5
    Alternative name(s):
    Hair keratin, type I Ha5
    Keratin-35
    Short name:
    K35
    Gene namesi
    Name:KRT35
    Synonyms:HHA5, HKA5, KRTHA5
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 17

    Organism-specific databases

    HGNCiHGNC:6453. KRT35.

    Subcellular locationi

    GO - Cellular componenti

    1. extracellular space Source: UniProt
    2. intermediate filament Source: UniProtKB-KW

    Keywords - Cellular componenti

    Intermediate filament, Keratin

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA30242.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 455455Keratin, type I cuticular Ha5PRO_0000063692Add
    BLAST

    Proteomic databases

    MaxQBiQ92764.
    PaxDbiQ92764.
    PRIDEiQ92764.

    PTM databases

    PhosphoSiteiQ92764.

    Expressioni

    Tissue specificityi

    Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.1 Publication

    Gene expression databases

    ArrayExpressiQ92764.
    BgeeiQ92764.
    CleanExiHS_KRT35.
    GenevestigatoriQ92764.

    Interactioni

    Protein-protein interaction databases

    BioGridi110084. 6 interactions.
    IntActiQ92764. 3 interactions.
    STRINGi9606.ENSP00000377558.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92764.
    SMRiQ92764. Positions 99-130, 147-245, 315-402.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 9797HeadAdd
    BLAST
    Regioni98 – 404307RodAdd
    BLAST
    Regioni98 – 13235Coil 1AAdd
    BLAST
    Regioni133 – 14311Linker 1Add
    BLAST
    Regioni144 – 244101Coil 1BAdd
    BLAST
    Regioni245 – 26016Linker 12Add
    BLAST
    Regioni261 – 404144Coil 2Add
    BLAST
    Regioni405 – 45551TailAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi33 – 364Poly-Ser
    Compositional biasi83 – 864Poly-Gly

    Sequence similaritiesi

    Belongs to the intermediate filament family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG145287.
    HOGENOMiHOG000230975.
    HOVERGENiHBG013015.
    InParanoidiQ92764.
    KOiK07604.
    OMAiARSFSAC.
    OrthoDBiEOG7FV3Q8.
    PhylomeDBiQ92764.
    TreeFamiTF332742.

    Family and domain databases

    InterProiIPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view]
    PANTHERiPTHR23239. PTHR23239. 1 hit.
    PfamiPF00038. Filament. 1 hit.
    [Graphical view]
    PRINTSiPR01248. TYPE1KERATIN.
    SUPFAMiSSF46579. SSF46579. 1 hit.
    PROSITEiPS00226. IF. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q92764-1 [UniParc]FASTAAdd to Basket

    « Hide

    MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS    50
    ACSVGLGRSS YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET 100
    MQSLNDRLAG YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT 150
    IEELQKKTLC SKAENARLVV EIDNAKLAAD DFRTKYETEV SLRQLVESDI 200
    NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL 250
    NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV 300
    SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS 350
    QLAQMQCMIT NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL 400
    LESEDSKLPC NPCAPDYSPS KSCLPCLPAA SCGPSAARTN CSPRPICVPC 450
    PGGRF 455
    Length:455
    Mass (Da):50,361
    Last modified:May 18, 2010 - v5
    Checksum:i3E72080469C8E80B
    GO

    Sequence cautioni

    The sequence CAA62286.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.
    The sequence CAA76387.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti117 – 1182QL → HV in CAA62286. (PubMed:8823373)Curated
    Sequence conflicti117 – 1182QL → HV in CAA76387. (PubMed:9756910)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti36 – 361S → P.1 Publication
    Corresponds to variant rs743686 [ dbSNP | Ensembl ].
    VAR_056019
    Natural varianti441 – 4411C → Y.
    Corresponds to variant rs12451652 [ dbSNP | Ensembl ].
    VAR_056020
    Natural varianti443 – 4431P → A.1 Publication
    Corresponds to variant rs2071601 [ dbSNP | Ensembl ].
    VAR_056021

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90762 Genomic DNA. Translation: CAA62285.1.
    X90763 mRNA. Translation: CAA62286.1. Different initiation.
    Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
    AC019349 Genomic DNA. No translation available.
    CCDSiCCDS11394.2.
    RefSeqiNP_002271.3. NM_002280.4.
    UniGeneiHs.73082.

    Genome annotation databases

    EnsembliENST00000393989; ENSP00000377558; ENSG00000197079.
    GeneIDi3886.
    KEGGihsa:3886.
    UCSCiuc002hws.3. human.

    Polymorphism databases

    DMDMi296439499.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X90762 Genomic DNA. Translation: CAA62285.1 .
    X90763 mRNA. Translation: CAA62286.1 . Different initiation.
    Y16791 Genomic DNA. Translation: CAA76387.1 . Different initiation.
    AC019349 Genomic DNA. No translation available.
    CCDSi CCDS11394.2.
    RefSeqi NP_002271.3. NM_002280.4.
    UniGenei Hs.73082.

    3D structure databases

    ProteinModelPortali Q92764.
    SMRi Q92764. Positions 99-130, 147-245, 315-402.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110084. 6 interactions.
    IntActi Q92764. 3 interactions.
    STRINGi 9606.ENSP00000377558.

    PTM databases

    PhosphoSitei Q92764.

    Polymorphism databases

    DMDMi 296439499.

    Proteomic databases

    MaxQBi Q92764.
    PaxDbi Q92764.
    PRIDEi Q92764.

    Protocols and materials databases

    DNASUi 3886.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000393989 ; ENSP00000377558 ; ENSG00000197079 .
    GeneIDi 3886.
    KEGGi hsa:3886.
    UCSCi uc002hws.3. human.

    Organism-specific databases

    CTDi 3886.
    GeneCardsi GC17M039632.
    H-InvDB HIX0039250.
    HGNCi HGNC:6453. KRT35.
    MIMi 602764. gene.
    neXtProti NX_Q92764.
    PharmGKBi PA30242.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG145287.
    HOGENOMi HOG000230975.
    HOVERGENi HBG013015.
    InParanoidi Q92764.
    KOi K07604.
    OMAi ARSFSAC.
    OrthoDBi EOG7FV3Q8.
    PhylomeDBi Q92764.
    TreeFami TF332742.

    Miscellaneous databases

    ChiTaRSi KRT35. human.
    GenomeRNAii 3886.
    NextBioi 15255.
    PROi Q92764.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92764.
    Bgeei Q92764.
    CleanExi HS_KRT35.
    Genevestigatori Q92764.

    Family and domain databases

    InterProi IPR001664. IF.
    IPR018039. Intermediate_filament_CS.
    IPR002957. Keratin_I.
    IPR009053. Prefoldin.
    [Graphical view ]
    PANTHERi PTHR23239. PTHR23239. 1 hit.
    Pfami PF00038. Filament. 1 hit.
    [Graphical view ]
    PRINTSi PR01248. TYPE1KERATIN.
    SUPFAMi SSF46579. SSF46579. 1 hit.
    PROSITEi PS00226. IF. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5."
      Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.
      J. Invest. Dermatol. 107:633-638(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455, TISSUE SPECIFICITY, VARIANTS PRO-36 AND ALA-443.
      Tissue: Hair and Scalp.
    2. "Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
      Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
      J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage."
      Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L.
      , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C.
      Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiKRT35_HUMAN
    AccessioniPrimary (citable) accession number: Q92764
    Secondary accession number(s): O76012, Q92651
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: May 18, 2010
    Last modified: October 1, 2014
    This is version 114 of the entry and version 5 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Miscellaneous

    There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 17
      Human chromosome 17: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3