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Reviewed, UniProtKB/Swiss-Prot Q92764 (KRT35_HUMAN)

Last modified July 7, 2009. Version 69. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (5) | Third-party data | Customize display text xml rdf/xml gff fasta
Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents

Names and origin

Protein namesRecommended name:
    Keratin, type I cuticular Ha5
Alternative name(s):
    Hair keratin, type I Ha5
    Keratin-35
      Short name=K35
Gene names
Name: KRT35
Synonyms: HHA5, HKA5, KRTHA5
OrganismHomo sapiens (Human) [Complete proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length455 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is not processed.
Protein existenceEvidence at transcript level.

General annotation (Comments)

Tissue specificity

Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb. Ref.1

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Sequence similarities

Belongs to the intermediate filament family.

Ontologies

Keywords
   Cellular componentIntermediate filament
Keratin
   Coding sequence diversityPolymorphism
   DomainCoiled coil
   Technical termComplete proteome
Gene Ontology (GO)
   Biological processanatomical structure morphogenesis Ref.1

Traceable author statement. Source: ProtInc

   Cellular componentintermediate filament

Inferred from electronic annotation. Source: UniProtKB-KW

   Molecular functionstructural molecule activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 455455Keratin, type I cuticular Ha5
PRO_0000063692

Regions

Region1 – 9797Head
Region98 – 404307Rod
Region98 – 13235Coil 1A
Region133 – 14311Linker 1
Region144 – 244101Coil 1B
Region245 – 26016Linker 12
Region261 – 404144Coil 2
Region405 – 45551Tail
Compositional bias33 – 364Poly-Ser
Compositional bias83 – 864Poly-Gly

Sites

Site3461Stutter

Natural variations

Natural variant361S → P: dbSNP rs743686.
VAR_056019
Natural variant4411C → Y: dbSNP rs12451652.
VAR_056020
Natural variant4431P → A: dbSNP rs2071601.
VAR_056021

Sequences

Sequence LengthMass (Da)Tools
Q92764-1 [UniParc].

Last modified January 20, 2009. Version 4.
Checksum: 84B96F94FAD21D2C

FASTA45550,356
        10         20         30         40         50         60 
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS 

        70         80         90        100        110        120 
YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRHVEQ 

       130        140        150        160        170        180 
ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD 

       190        200        210        220        230        240 
DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN 

       250        260        270        280        290        300 
SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV 

       310        320        330        340        350        360 
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT 

       370        380        390        400        410        420 
NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS 

       430        440        450 
KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF 

« Hide

References

[1]"Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5."
Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J.
J. Invest. Dermatol. 107:633-638(1996) [PubMed: 8823373] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455, TISSUE SPECIFICITY, VARIANTS PRO-36 AND ALA-443.
Tissue: Hair and Scalp.
[2]"Characterization of a 190-kilobase pair domain of human type I hair keratin genes."
Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J.
J. Biol. Chem. 273:26683-26691(1998) [PubMed: 9756910] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

X90762 Genomic DNA. Translation: CAA62285.1.
X90763 mRNA. Translation: CAA62286.1. Different initiation.
Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
IPIIPI00790172.
RefSeqNP_002271.3.
UniGeneHs.73082

3D structure databases

HSSPHSSP built from PDB template 1GK7 based on UniProtKB P08670.
ModBaseSearch...

PTM databases

PhosphoSiteQ92764.

Genome annotation databases

EnsemblENSG00000197079. Homo sapiens. [Contig view]
GeneID3886.
KEGGhsa:3886.
UCSCuc002hws.1. human.

Organism-specific databases

GeneCardsGC17M036887.
H-InvDBHIX0039250.
HGNCHGNC:6453. KRT35.
MIM602764. gene.
PharmGKBPA30242.
GenAtlasSearch...

Phylogenomic databases

HOGENOMQ92764.
HOVERGENQ92764.

Gene expression databases

ArrayExpressQ92764.
BgeeQ92764.
CleanExHS_KRT35.
GermOnlineENSG00000197079. Homo sapiens.

Family and domain databases

InterProIPR016044. F.
IPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
[Graphical view]
PANTHERPTHR23239. IF. 1 hit.
PfamPF00038. Filament. 1 hit.
[Graphical view]
PRINTSPR01248. TYPE1KERATIN.
PROSITEPS00226. IF. 1 hit.
[Graphical view]
ProtoNetSearch...

Other Resources

NextBio15255.
SOURCESearch...

Entry information

Entry nameKRT35_HUMAN
AccessionPrimary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651
Entry history
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: January 20, 2009
Last modified: July 7, 2009
This is version 69 of the entry and version 4 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation projectHPI (Human Proteome Initiative)

Relevant documents

Human chromosome 17

Human chromosome 17: entries, gene names and cross-references to MIM

Human entries with polymorphisms or disease mutations

List of human entries with polymorphisms or disease mutations

Human polymorphisms and disease mutations

Index of human polymorphisms and disease mutations

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names and origin · Protein attributes · General annotation (Comments) · Ontologies · Sequence annotation (Features) · Sequences · References · Cross-references · Entry information · Relevant documents