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Protein

Keratin, type I cuticular Ha5

Gene

KRT35

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sitei346Stutter1

GO - Molecular functioni

GO - Biological processi

  • anatomical structure morphogenesis Source: ProtInc
Complete GO annotation...

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126337-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Names & Taxonomyi

Protein namesi
Recommended name:
Keratin, type I cuticular Ha5
Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name:
K35
Gene namesi
Name:KRT35
Synonyms:HHA5, HKA5, KRTHA5
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 17

Organism-specific databases

HGNCiHGNC:6453. KRT35.

Subcellular locationi

GO - Cellular componenti

  • extracellular exosome Source: UniProtKB
  • extracellular space Source: UniProtKB
  • intermediate filament Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Intermediate filament, Keratin

Pathology & Biotechi

Organism-specific databases

DisGeNETi3886.
OpenTargetsiENSG00000197079.
PharmGKBiPA30242.

Polymorphism and mutation databases

BioMutaiKRT35.
DMDMi296439499.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000636921 – 455Keratin, type I cuticular Ha5Add BLAST455

Proteomic databases

EPDiQ92764.
PaxDbiQ92764.
PeptideAtlasiQ92764.
PRIDEiQ92764.

PTM databases

iPTMnetiQ92764.
PhosphoSitePlusiQ92764.

Expressioni

Tissue specificityi

Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb.1 Publication

Gene expression databases

BgeeiENSG00000197079.
CleanExiHS_KRT35.
ExpressionAtlasiQ92764. baseline and differential.
GenevisibleiQ92764. HS.

Interactioni

Protein-protein interaction databases

BioGridi110084. 5 interactors.
IntActiQ92764. 86 interactors.
STRINGi9606.ENSP00000377558.

Structurei

3D structure databases

ProteinModelPortaliQ92764.
SMRiQ92764.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 97HeadAdd BLAST97
Regioni98 – 404RodAdd BLAST307
Regioni98 – 132Coil 1AAdd BLAST35
Regioni133 – 143Linker 1Add BLAST11
Regioni144 – 244Coil 1BAdd BLAST101
Regioni245 – 260Linker 12Add BLAST16
Regioni261 – 404Coil 2Add BLAST144
Regioni405 – 455TailAdd BLAST51

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi33 – 36Poly-Ser4
Compositional biasi83 – 86Poly-Gly4

Sequence similaritiesi

Belongs to the intermediate filament family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiENOG410IHJD. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ92764.
KOiK07604.
OMAiYRATSCL.
OrthoDBiEOG091G087I.
PhylomeDBiQ92764.
TreeFamiTF332742.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92764-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS
60 70 80 90 100
ACSVGLGRSS YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET
110 120 130 140 150
MQSLNDRLAG YLEKVRQLEQ ENASLESRIR EWCEQQVPYM CPDYQSYFRT
160 170 180 190 200
IEELQKKTLC SKAENARLVV EIDNAKLAAD DFRTKYETEV SLRQLVESDI
210 220 230 240 250
NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN SLRCQLGDRL
260 270 280 290 300
NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV
310 320 330 340 350
SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS
360 370 380 390 400
QLAQMQCMIT NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL
410 420 430 440 450
LESEDSKLPC NPCAPDYSPS KSCLPCLPAA SCGPSAARTN CSPRPICVPC

PGGRF
Length:455
Mass (Da):50,361
Last modified:May 18, 2010 - v5
Checksum:i3E72080469C8E80B
GO

Sequence cautioni

The sequence CAA62286 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated
The sequence CAA76387 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.Curated

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti117 – 118QL → HV in CAA62286 (PubMed:8823373).Curated2
Sequence conflicti117 – 118QL → HV in CAA76387 (PubMed:9756910).Curated2

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_05601936S → P.1 PublicationCorresponds to variant rs743686dbSNPEnsembl.1
Natural variantiVAR_056020441C → Y.Corresponds to variant rs12451652dbSNPEnsembl.1
Natural variantiVAR_056021443P → A.1 PublicationCorresponds to variant rs2071601dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90762 Genomic DNA. Translation: CAA62285.1.
X90763 mRNA. Translation: CAA62286.1. Different initiation.
Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
AC019349 Genomic DNA. No translation available.
CCDSiCCDS11394.2.
RefSeqiNP_002271.3. NM_002280.4.
XP_011523096.1. XM_011524794.1.
UniGeneiHs.73082.

Genome annotation databases

EnsembliENST00000393989; ENSP00000377558; ENSG00000197079.
GeneIDi3886.
KEGGihsa:3886.
UCSCiuc002hws.4. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X90762 Genomic DNA. Translation: CAA62285.1.
X90763 mRNA. Translation: CAA62286.1. Different initiation.
Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation.
AC019349 Genomic DNA. No translation available.
CCDSiCCDS11394.2.
RefSeqiNP_002271.3. NM_002280.4.
XP_011523096.1. XM_011524794.1.
UniGeneiHs.73082.

3D structure databases

ProteinModelPortaliQ92764.
SMRiQ92764.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi110084. 5 interactors.
IntActiQ92764. 86 interactors.
STRINGi9606.ENSP00000377558.

PTM databases

iPTMnetiQ92764.
PhosphoSitePlusiQ92764.

Polymorphism and mutation databases

BioMutaiKRT35.
DMDMi296439499.

Proteomic databases

EPDiQ92764.
PaxDbiQ92764.
PeptideAtlasiQ92764.
PRIDEiQ92764.

Protocols and materials databases

DNASUi3886.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000393989; ENSP00000377558; ENSG00000197079.
GeneIDi3886.
KEGGihsa:3886.
UCSCiuc002hws.4. human.

Organism-specific databases

CTDi3886.
DisGeNETi3886.
GeneCardsiKRT35.
H-InvDBHIX0039250.
HGNCiHGNC:6453. KRT35.
MIMi602764. gene.
neXtProtiNX_Q92764.
OpenTargetsiENSG00000197079.
PharmGKBiPA30242.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiENOG410IHJD. Eukaryota.
ENOG410YK2A. LUCA.
GeneTreeiENSGT00760000118808.
HOGENOMiHOG000230975.
HOVERGENiHBG013015.
InParanoidiQ92764.
KOiK07604.
OMAiYRATSCL.
OrthoDBiEOG091G087I.
PhylomeDBiQ92764.
TreeFamiTF332742.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000126337-MONOMER.
ReactomeiR-HSA-6805567. Keratinization.
R-HSA-6809371. Formation of the cornified envelope.

Miscellaneous databases

GenomeRNAii3886.
PROiQ92764.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000197079.
CleanExiHS_KRT35.
ExpressionAtlasiQ92764. baseline and differential.
GenevisibleiQ92764. HS.

Family and domain databases

InterProiIPR001664. IF.
IPR018039. Intermediate_filament_CS.
IPR002957. Keratin_I.
IPR009053. Prefoldin.
[Graphical view]
PANTHERiPTHR23239. PTHR23239. 1 hit.
PfamiPF00038. Filament. 1 hit.
[Graphical view]
PRINTSiPR01248. TYPE1KERATIN.
SMARTiSM01391. Filament. 1 hit.
[Graphical view]
SUPFAMiSSF46579. SSF46579. 1 hit.
PROSITEiPS00226. IF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiKRT35_HUMAN
AccessioniPrimary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: May 18, 2010
Last modified: November 30, 2016
This is version 135 of the entry and version 5 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Miscellaneous

There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 17
    Human chromosome 17: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.