Q92764 (KRT35_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Keratin, type I cuticular Ha5

Alternative name(s):
Hair keratin, type I Ha5
Keratin-35
Short name=K35

Gene names

Name:	KRT35
Synonyms:	HHA5, HKA5, KRTHA5

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	455 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Tissue specificity	Early expression in the hair follicle, mainly found in supramatricial cells and lowermost cortical cells of the hair bulb. Ref.1
Miscellaneous	There are two types of hair/microfibrillar keratin, I (acidic) and II (neutral to basic).
Sequence similarities	Belongs to the intermediate filament family.
Sequence caution	The sequence CAA62286.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended. The sequence CAA76387.1 differs from that shown. Reason: Erroneous initiation. Translation N-terminally extended.

Ontologies

Keywords
Cellular component	Intermediate filament Keratin
Coding sequence diversity	Polymorphism
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	anatomical structure morphogenesis Traceable author statement Ref.1. Source: ProtInc
Cellular_component	intermediate filament Inferred from electronic annotation. Source: UniProtKB-KW
Molecular_function	structural molecule activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 455	455	Keratin, type I cuticular Ha5		PRO_0000063692
Regions
	Region	1 – 97	97	Head
	Region	98 – 404	307	Rod
	Region	98 – 132	35	Coil 1A
	Region	133 – 143	11	Linker 1
	Region	144 – 244	101	Coil 1B
	Region	245 – 260	16	Linker 12
	Region	261 – 404	144	Coil 2
	Region	405 – 455	51	Tail
	Compositional bias	33 – 36	4	Poly-Ser
	Compositional bias	83 – 86	4	Poly-Gly
Sites
	Site	346	1	Stutter
Natural variations
	Natural variant	36	1	S → P. Ref.1 Corresponds to variant rs743686 [ dbSNP | Ensembl ].		VAR_056019
	Natural variant	441	1	C → Y. Corresponds to variant rs12451652 [ dbSNP | Ensembl ].		VAR_056020
	Natural variant	443	1	P → A. Ref.1 Corresponds to variant rs2071601 [ dbSNP | Ensembl ].		VAR_056021
Experimental info
	Sequence conflict	117 – 118	2	QL → HV in CAA62286. Ref.1
	Sequence conflict	117 – 118	2	QL → HV in CAA76387. Ref.2

Sequences

	Sequence		Length	Mass (Da)
	Q92764 [UniParc]. Last modified May 18, 2010. Version 5. Checksum: 3E72080469C8E80B	FASTA	455	50,361
	10 20 30 40 50 60 MASKCLKAGF SSGSLKSPGG ASGGSTRVSA MYSSSSCKLP SLSPVARSFS ACSVGLGRSS 70 80 90 100 110 120 YRATSCLPAL CLPAGGFATS YSGGGGWFGE GILTGNEKET MQSLNDRLAG YLEKVRQLEQ 130 140 150 160 170 180 ENASLESRIR EWCEQQVPYM CPDYQSYFRT IEELQKKTLC SKAENARLVV EIDNAKLAAD 190 200 210 220 230 240 DFRTKYETEV SLRQLVESDI NGLRRILDDL TLCKSDLEAQ VESLKEELLC LKKNHEEEVN 250 260 270 280 290 300 SLRCQLGDRL NVEVDAAPPV DLNRVLEEMR CQYETLVENN RRDAEDWLDT QSEELNQQVV 310 320 330 340 350 360 SSSEQLQSCQ AEIIELRRTV NALEIELQAQ HSMRDALEST LAETEARYSS QLAQMQCMIT 370 380 390 400 410 420 NVEAQLAEIR ADLERQNQEY QVLLDVRARL ECEINTYRGL LESEDSKLPC NPCAPDYSPS 430 440 450 KSCLPCLPAA SCGPSAARTN CSPRPICVPC PGGRF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Genomic characterization of the human type I cuticular hair keratin hHa2 and identification of an adjacent novel type I hair keratin gene hHa5." Rogers M.A., Winter H., Langbein L., Krieg T., Schweizer J. J. Invest. Dermatol. 107:633-638(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 334-455, TISSUE SPECIFICITY, VARIANTS PRO-36 AND ALA-443. Tissue: Hair and Scalp.
[2]	"Characterization of a 190-kilobase pair domain of human type I hair keratin genes." Rogers M.A., Winter H., Wolf C., Heck M., Schweizer J. J. Biol. Chem. 273:26683-26691(1998) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"DNA sequence of human chromosome 17 and analysis of rearrangement in the human lineage." Zody M.C., Garber M., Adams D.J., Sharpe T., Harrow J., Lupski J.R., Nicholson C., Searle S.M., Wilming L., Young S.K., Abouelleil A., Allen N.R., Bi W., Bloom T., Borowsky M.L., Bugalter B.E., Butler J., Chang J.L. , Chen C.-K., Cook A., Corum B., Cuomo C.A., de Jong P.J., DeCaprio D., Dewar K., FitzGerald M., Gilbert J., Gibson R., Gnerre S., Goldstein S., Grafham D.V., Grocock R., Hafez N., Hagopian D.S., Hart E., Norman C.H., Humphray S., Jaffe D.B., Jones M., Kamal M., Khodiyar V.K., LaButti K., Laird G., Lehoczky J., Liu X., Lokyitsang T., Loveland J., Lui A., Macdonald P., Major J.E., Matthews L., Mauceli E., McCarroll S.A., Mihalev A.H., Mudge J., Nguyen C., Nicol R., O'Leary S.B., Osoegawa K., Schwartz D.C., Shaw-Smith C., Stankiewicz P., Steward C., Swarbreck D., Venkataraman V., Whittaker C.A., Yang X., Zimmer A.R., Bradley A., Hubbard T., Birren B.W., Rogers J., Lander E.S., Nusbaum C. Nature 440:1045-1049(2006) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	X90762 Genomic DNA. Translation: CAA62285.1. X90763 mRNA. Translation: CAA62286.1. Different initiation. Y16791 Genomic DNA. Translation: CAA76387.1. Different initiation. AC019349 Genomic DNA. No translation available.
IPI	IPI00790172.
RefSeq	NP_002271.3. NM_002280.4.
UniGene	Hs.73082.
3D structure databases
ProteinModelPortal	Q92764.
SMR	Q92764. Positions 147-245, 315-402.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92764. 3 interactions.
STRING	9606.ENSP00000377558.
PTM databases
PhosphoSite	Q92764.
Polymorphism databases
DMDM	296439499.
Proteomic databases
PaxDb	Q92764.
PRIDE	Q92764.
Protocols and materials databases
DNASU	3886.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000393989; ENSP00000377558; ENSG00000197079.
GeneID	3886.
KEGG	hsa:3886.
UCSC	uc002hws.3. human.
Organism-specific databases
CTD	3886.
GeneCards	GC17M039632.
H-InvDB	HIX0039250.
HGNC	HGNC:6453. KRT35.
MIM	602764. gene.
neXtProt	NX_Q92764.
PharmGKB	PA30242.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG145287.
HOGENOM	HOG000230975.
HOVERGEN	HBG013015.
InParanoid	Q92764.
KO	K07604.
OMA	ARSFSAC.
Gene expression databases
ArrayExpress	Q92764.
Bgee	Q92764.
CleanEx	HS_KRT35.
Genevestigator	Q92764.
GermOnline	ENSG00000197079. Homo sapiens.
Family and domain databases
InterPro	IPR016044. F. IPR001664. IF. IPR018039. Intermediate_filament_CS. IPR002957. Keratin_I. [Graphical view]
PANTHER	PTHR23239. PTHR23239. 1 hit.
Pfam	PF00038. Filament. 1 hit. [Graphical view]
PRINTS	PR01248. TYPE1KERATIN.
PROSITE	PS00226. IF. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	KRT35. human.
GenomeRNAi	3886.
NextBio	15255.
SOURCE	Search...

Entry information

Entry name

KRT35_HUMAN

Accession

Primary (citable) accession number: Q92764
Secondary accession number(s): O76012, Q92651

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	May 18, 2010
Last modified:	May 1, 2013
This is version 102 of the entry and version 5 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.