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Q92759

- TF2H4_HUMAN

UniProt

Q92759 - TF2H4_HUMAN

Protein

General transcription factor IIH subunit 4

Gene

GTF2H4

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 131 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Component of the core-TFIIH basal transcription factor involved in nucleotide excision repair (NER) of DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II.

    GO - Molecular functioni

    1. ATP-dependent DNA helicase activity Source: InterPro
    2. protein binding Source: UniProtKB
    3. sequence-specific DNA binding transcription factor activity Source: ProtInc

    GO - Biological processi

    1. 7-methylguanosine mRNA capping Source: Reactome
    2. ATP catabolic process Source: GOC
    3. DNA repair Source: Reactome
    4. gene expression Source: Reactome
    5. nucleotide-excision repair Source: Reactome
    6. nucleotide-excision repair, DNA damage removal Source: Reactome
    7. positive regulation of viral transcription Source: Reactome
    8. protein phosphorylation Source: GOC
    9. termination of RNA polymerase I transcription Source: Reactome
    10. transcription-coupled nucleotide-excision repair Source: Reactome
    11. transcription elongation from RNA polymerase II promoter Source: Reactome
    12. transcription elongation from RNA polymerase I promoter Source: Reactome
    13. transcription from RNA polymerase II promoter Source: UniProtKB
    14. transcription from RNA polymerase I promoter Source: Reactome
    15. transcription initiation from RNA polymerase II promoter Source: Reactome
    16. transcription initiation from RNA polymerase I promoter Source: Reactome
    17. viral process Source: Reactome

    Keywords - Biological processi

    DNA damage, DNA repair, Transcription, Transcription regulation

    Enzyme and pathway databases

    ReactomeiREACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1470. mRNA Capping.
    REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
    REACT_2222. Dual incision reaction in TC-NER.
    REACT_257. Formation of incision complex in GG-NER.
    REACT_311. Dual incision reaction in GG-NER.
    REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
    REACT_6233. Transcription of the HIV genome.
    REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6319. Formation of the HIV-1 Early Elongation Complex.
    REACT_6332. HIV Transcription Initiation.
    REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
    REACT_833. RNA Polymerase II Transcription Elongation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
    REACT_846. Formation of the Early Elongation Complex.
    REACT_953. RNA Polymerase I Transcription Initiation.
    REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    General transcription factor IIH subunit 4
    Alternative name(s):
    Basic transcription factor 2 52 kDa subunit
    Short name:
    BTF2 p52
    General transcription factor IIH polypeptide 4
    TFIIH basal transcription factor complex p52 subunit
    Gene namesi
    Name:GTF2H4
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 6

    Organism-specific databases

    HGNCiHGNC:4658. GTF2H4.

    Subcellular locationi

    GO - Cellular componenti

    1. core TFIIH complex Source: InterPro
    2. holo TFIIH complex Source: UniProtKB
    3. nucleoplasm Source: Reactome

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA29044.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 462462General transcription factor IIH subunit 4PRO_0000119253Add
    BLAST

    Proteomic databases

    MaxQBiQ92759.
    PaxDbiQ92759.
    PRIDEiQ92759.

    PTM databases

    PhosphoSiteiQ92759.

    Expressioni

    Gene expression databases

    BgeeiQ92759.
    CleanExiHS_GTF2H4.
    GenevestigatoriQ92759.

    Interactioni

    Subunit structurei

    One of the 6 subunits forming the core-TFIIH basal transcription factor which associates with the CAK complex composed of CDK7, CCNH/cyclin H and MNAT1 to form the TFIIH basal transcription factor.1 Publication

    Protein-protein interaction databases

    BioGridi109223. 21 interactions.
    DIPiDIP-48376N.
    IntActiQ92759. 1 interaction.
    MINTiMINT-3049325.
    STRINGi9606.ENSP00000259895.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92759.
    SMRiQ92759. Positions 382-457.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the TFB2 family.Curated

    Phylogenomic databases

    eggNOGiCOG5144.
    HOGENOMiHOG000170529.
    HOVERGENiHBG054205.
    InParanoidiQ92759.
    KOiK03144.
    OMAiPHAQLWE.
    PhylomeDBiQ92759.
    TreeFamiTF300879.

    Family and domain databases

    InterProiIPR004598. TFIIH_p52/Tfb2.
    [Graphical view]
    PANTHERiPTHR13152. PTHR13152. 1 hit.
    PfamiPF03849. Tfb2. 1 hit.
    [Graphical view]
    TIGRFAMsiTIGR00625. tfb2. 1 hit.

    Sequencei

    Sequence statusi: Complete.

    Q92759-1 [UniParc]FASTAAdd to Basket

    « Hide

    MESTPSRGLN RVHLQCRNLQ EFLGGLSPGV LDRLYGHPAT CLAVFRELPS    50
    LAKNWVMRML FLEQPLPQAA VALWVKKEFS KAQEESTGLL SGLRIWHTQL 100
    LPGGLQGLIL NPIFRQNLRI ALLGGGKAWS DDTSQLGPDK HARDVPSLDK 150
    YAEERWEVVL HFMVGSPSAA VSQDLAQLLS QAGLMKSTEP GEPPCITSAG 200
    FQFLLLDTPA QLWYFMLQYL QTAQSRGMDL VEILSFLFQL SFSTLGKDYS 250
    VEGMSDSLLN FLQHLREFGL VFQRKRKSRR YYPTRLAINL SSGVSGAGGT 300
    VHQPGFIVVE TNYRLYAYTE SELQIALIAL FSEMLYRFPN MVVAQVTRES 350
    VQQAIASGIT AQQIIHFLRT RAHPVMLKQT PVLPPTITDQ IRLWELERDR 400
    LRFTEGVLYN QFLSQVDFEL LLAHARELGV LVFENSAKRL MVVTPAGHSD 450
    VKRFWKRQKH SS 462
    Length:462
    Mass (Da):52,186
    Last modified:February 1, 1997 - v1
    Checksum:i5532DAD617CA743C
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti337 – 3371R → Q.1 Publication
    Corresponds to variant rs3218820 [ dbSNP | Ensembl ].
    VAR_019056

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07595 mRNA. Translation: CAA68870.1.
    BA000025 Genomic DNA. Translation: BAB63317.1.
    BT007321 mRNA. Translation: AAP35985.1.
    AY124590 Genomic DNA. Translation: AAM64222.1.
    AB088103 Genomic DNA. Translation: BAC54936.1.
    AB202101 Genomic DNA. Translation: BAE78622.1.
    AB103609 Genomic DNA. Translation: BAF31271.1.
    AL773541 Genomic DNA. Translation: CAI18452.1.
    CR759747 Genomic DNA. Translation: CAQ06761.1.
    BX927194 Genomic DNA. Translation: CAQ09772.1.
    CR936875 Genomic DNA. Translation: CAQ10923.1.
    CH471081 Genomic DNA. Translation: EAX03347.1.
    BC004935 mRNA. Translation: AAH04935.1.
    BC016302 mRNA. Translation: AAH16302.1.
    CCDSiCCDS34386.1.
    RefSeqiNP_001508.1. NM_001517.4.
    UniGeneiHs.485070.

    Genome annotation databases

    EnsembliENST00000259895; ENSP00000259895; ENSG00000213780.
    ENST00000376316; ENSP00000365493; ENSG00000213780.
    ENST00000376326; ENSP00000365504; ENSG00000221974.
    ENST00000400450; ENSP00000383300; ENSG00000221974.
    ENST00000413314; ENSP00000396251; ENSG00000236895.
    ENST00000416773; ENSP00000399554; ENSG00000234370.
    ENST00000423881; ENSP00000409483; ENSG00000236895.
    ENST00000434226; ENSP00000403156; ENSG00000234370.
    ENST00000435498; ENSP00000388227; ENSG00000233149.
    ENST00000438348; ENSP00000387980; ENSG00000226384.
    ENST00000440824; ENSP00000401105; ENSG00000226384.
    ENST00000456968; ENSP00000395497; ENSG00000233149.
    GeneIDi2968.
    KEGGihsa:2968.
    UCSCiuc003nsa.1. human.

    Polymorphism databases

    DMDMi17380328.

    Keywords - Coding sequence diversityi

    Polymorphism

    Cross-referencesi

    Web resourcesi

    NIEHS-SNPs

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07595 mRNA. Translation: CAA68870.1 .
    BA000025 Genomic DNA. Translation: BAB63317.1 .
    BT007321 mRNA. Translation: AAP35985.1 .
    AY124590 Genomic DNA. Translation: AAM64222.1 .
    AB088103 Genomic DNA. Translation: BAC54936.1 .
    AB202101 Genomic DNA. Translation: BAE78622.1 .
    AB103609 Genomic DNA. Translation: BAF31271.1 .
    AL773541 Genomic DNA. Translation: CAI18452.1 .
    CR759747 Genomic DNA. Translation: CAQ06761.1 .
    BX927194 Genomic DNA. Translation: CAQ09772.1 .
    CR936875 Genomic DNA. Translation: CAQ10923.1 .
    CH471081 Genomic DNA. Translation: EAX03347.1 .
    BC004935 mRNA. Translation: AAH04935.1 .
    BC016302 mRNA. Translation: AAH16302.1 .
    CCDSi CCDS34386.1.
    RefSeqi NP_001508.1. NM_001517.4.
    UniGenei Hs.485070.

    3D structure databases

    ProteinModelPortali Q92759.
    SMRi Q92759. Positions 382-457.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 109223. 21 interactions.
    DIPi DIP-48376N.
    IntActi Q92759. 1 interaction.
    MINTi MINT-3049325.
    STRINGi 9606.ENSP00000259895.

    PTM databases

    PhosphoSitei Q92759.

    Polymorphism databases

    DMDMi 17380328.

    Proteomic databases

    MaxQBi Q92759.
    PaxDbi Q92759.
    PRIDEi Q92759.

    Protocols and materials databases

    DNASUi 2968.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000259895 ; ENSP00000259895 ; ENSG00000213780 .
    ENST00000376316 ; ENSP00000365493 ; ENSG00000213780 .
    ENST00000376326 ; ENSP00000365504 ; ENSG00000221974 .
    ENST00000400450 ; ENSP00000383300 ; ENSG00000221974 .
    ENST00000413314 ; ENSP00000396251 ; ENSG00000236895 .
    ENST00000416773 ; ENSP00000399554 ; ENSG00000234370 .
    ENST00000423881 ; ENSP00000409483 ; ENSG00000236895 .
    ENST00000434226 ; ENSP00000403156 ; ENSG00000234370 .
    ENST00000435498 ; ENSP00000388227 ; ENSG00000233149 .
    ENST00000438348 ; ENSP00000387980 ; ENSG00000226384 .
    ENST00000440824 ; ENSP00000401105 ; ENSG00000226384 .
    ENST00000456968 ; ENSP00000395497 ; ENSG00000233149 .
    GeneIDi 2968.
    KEGGi hsa:2968.
    UCSCi uc003nsa.1. human.

    Organism-specific databases

    CTDi 2968.
    GeneCardsi GC06P030875.
    GC06Pj30866.
    GC06Pk30867.
    GC06Pl30921.
    GC06Pm30955.
    GC06Pn30866.
    HGNCi HGNC:4658. GTF2H4.
    MIMi 601760. gene.
    neXtProti NX_Q92759.
    PharmGKBi PA29044.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi COG5144.
    HOGENOMi HOG000170529.
    HOVERGENi HBG054205.
    InParanoidi Q92759.
    KOi K03144.
    OMAi PHAQLWE.
    PhylomeDBi Q92759.
    TreeFami TF300879.

    Enzyme and pathway databases

    Reactomei REACT_1074. RNA Polymerase I Transcription Termination.
    REACT_1470. mRNA Capping.
    REACT_1655. RNA Polymerase II Transcription Pre-Initiation And Promoter Opening.
    REACT_1851. RNA Polymerase II Transcription Initiation.
    REACT_1913. RNA Polymerase I Promoter Escape.
    REACT_1941. Formation of transcription-coupled NER (TC-NER) repair complex.
    REACT_200856. NoRC negatively regulates rRNA expression.
    REACT_2089. RNA Polymerase II Promoter Escape.
    REACT_2204. RNA Polymerase I Chain Elongation.
    REACT_22107. RNA Polymerase II Pre-transcription Events.
    REACT_22201. Formation of HIV elongation complex in the absence of HIV Tat.
    REACT_2222. Dual incision reaction in TC-NER.
    REACT_257. Formation of incision complex in GG-NER.
    REACT_311. Dual incision reaction in GG-NER.
    REACT_6162. Tat-mediated elongation of the HIV-1 transcript.
    REACT_6233. Transcription of the HIV genome.
    REACT_6237. RNA Pol II CTD phosphorylation and interaction with CE.
    REACT_6253. RNA Polymerase II HIV Promoter Escape.
    REACT_6319. Formation of the HIV-1 Early Elongation Complex.
    REACT_6332. HIV Transcription Initiation.
    REACT_6346. Formation of HIV-1 elongation complex containing HIV-1 Tat.
    REACT_833. RNA Polymerase II Transcription Elongation.
    REACT_834. RNA Polymerase II Transcription Initiation And Promoter Clearance.
    REACT_846. Formation of the Early Elongation Complex.
    REACT_953. RNA Polymerase I Transcription Initiation.
    REACT_975. RNA Pol II CTD phosphorylation and interaction with CE.

    Miscellaneous databases

    GeneWikii GTF2H4.
    GenomeRNAii 2968.
    NextBioi 11764.
    PROi Q92759.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92759.
    CleanExi HS_GTF2H4.
    Genevestigatori Q92759.

    Family and domain databases

    InterProi IPR004598. TFIIH_p52/Tfb2.
    [Graphical view ]
    PANTHERi PTHR13152. PTHR13152. 1 hit.
    Pfami PF03849. Tfb2. 1 hit.
    [Graphical view ]
    TIGRFAMsi TIGR00625. tfb2. 1 hit.
    ProtoNeti Search...

    Publicationsi

    1. "Cloning and characterization of p52, the fifth subunit of the core of the transcription/DNA repair factor TFIIH."
      Marinoni J.-C., Roy R., Vermeulen W., Miniou P., Lutz Y., Weeda G., Seroz T., Molina Gomez D., Hoeijmakers J.H.J., Egly J.-M.
      EMBO J. 16:1093-1102(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Pre-B cell.
    2. "Homo sapiens 2,229,817bp genomic DNA of 6p21.3 HLA class I region."
      Shiina S., Tamiya G., Oka A., Inoko H.
      Submitted (SEP-1999) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    4. NIEHS SNPs program
      Submitted (JUN-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA], VARIANT GLN-337.
    5. "Rapid evolution of major histocompatibility complex class I genes in primates generates new disease alleles in humans via hitchhiking diversity."
      Shiina T., Ota M., Shimizu S., Katsuyama Y., Hashimoto N., Takasu M., Anzai T., Kulski J.K., Kikkawa E., Naruse T., Kimura N., Yanagiya K., Watanabe A., Hosomichi K., Kohara S., Iwamoto C., Umehara Y., Meyer A.
      , Wanner V., Sano K., Macquin C., Ikeo K., Tokunaga K., Gojobori T., Inoko H., Bahram S.
      Genetics 173:1555-1570(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Tissue: Peripheral blood leukocyte.
    6. "The DNA sequence and analysis of human chromosome 6."
      Mungall A.J., Palmer S.A., Sims S.K., Edwards C.A., Ashurst J.L., Wilming L., Jones M.C., Horton R., Hunt S.E., Scott C.E., Gilbert J.G.R., Clamp M.E., Bethel G., Milne S., Ainscough R., Almeida J.P., Ambrose K.D., Andrews T.D.
      , Ashwell R.I.S., Babbage A.K., Bagguley C.L., Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beare D.M., Beasley H., Beasley O., Bird C.P., Blakey S.E., Bray-Allen S., Brook J., Brown A.J., Brown J.Y., Burford D.C., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Clark S.Y., Clark G., Clee C.M., Clegg S., Cobley V., Collier R.E., Collins J.E., Colman L.K., Corby N.R., Coville G.J., Culley K.M., Dhami P., Davies J., Dunn M., Earthrowl M.E., Ellington A.E., Evans K.A., Faulkner L., Francis M.D., Frankish A., Frankland J., French L., Garner P., Garnett J., Ghori M.J., Gilby L.M., Gillson C.J., Glithero R.J., Grafham D.V., Grant M., Gribble S., Griffiths C., Griffiths M.N.D., Hall R., Halls K.S., Hammond S., Harley J.L., Hart E.A., Heath P.D., Heathcott R., Holmes S.J., Howden P.J., Howe K.L., Howell G.R., Huckle E., Humphray S.J., Humphries M.D., Hunt A.R., Johnson C.M., Joy A.A., Kay M., Keenan S.J., Kimberley A.M., King A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C.R., Lloyd D.M., Loveland J.E., Lovell J., Martin S., Mashreghi-Mohammadi M., Maslen G.L., Matthews L., McCann O.T., McLaren S.J., McLay K., McMurray A., Moore M.J.F., Mullikin J.C., Niblett D., Nickerson T., Novik K.L., Oliver K., Overton-Larty E.K., Parker A., Patel R., Pearce A.V., Peck A.I., Phillimore B.J.C.T., Phillips S., Plumb R.W., Porter K.M., Ramsey Y., Ranby S.A., Rice C.M., Ross M.T., Searle S.M., Sehra H.K., Sheridan E., Skuce C.D., Smith S., Smith M., Spraggon L., Squares S.L., Steward C.A., Sycamore N., Tamlyn-Hall G., Tester J., Theaker A.J., Thomas D.W., Thorpe A., Tracey A., Tromans A., Tubby B., Wall M., Wallis J.M., West A.P., White S.S., Whitehead S.L., Whittaker H., Wild A., Willey D.J., Wilmer T.E., Wood J.M., Wray P.W., Wyatt J.C., Young L., Younger R.M., Bentley D.R., Coulson A., Durbin R.M., Hubbard T., Sulston J.E., Dunham I., Rogers J., Beck S.
      Nature 425:805-811(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Skin and Uterus.
    9. "Immunoaffinity purification and functional characterization of human transcription factor IIH and RNA polymerase II from clonal cell lines that conditionally express epitope-tagged subunits of the multiprotein complexes."
      Kershnar E., Wu S.-Y., Chiang C.-M.
      J. Biol. Chem. 273:34444-34453(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION IN THE TFIIH BASAL TRANSCRIPTION FACTOR.

    Entry informationi

    Entry nameiTF2H4_HUMAN
    AccessioniPrimary (citable) accession number: Q92759
    Secondary accession number(s): Q76KU4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 18, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 131 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 6
      Human chromosome 6: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3