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Protein

Transcription factor AP-2 gamma

Gene

TFAP2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.2 Publications

GO - Molecular functioni

  • core promoter binding Source: UniProtKB
  • DNA binding Source: UniProtKB
  • protein dimerization activity Source: UniProtKB
  • RNA polymerase II regulatory region sequence-specific DNA binding Source: GO_Central
  • transcriptional activator activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: UniProtKB
  • transcriptional repressor activity, RNA polymerase II core promoter proximal region sequence-specific binding Source: UniProtKB
  • transcription factor activity, sequence-specific DNA binding Source: ProtInc

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • male gonad development Source: UniProtKB
  • positive regulation of transcription from RNA polymerase II promoter Source: BHF-UCL
  • regulation of cell proliferation Source: GO_Central
  • regulation of gene expression, epigenetic Source: UniProtKB
  • regulation of transcription from RNA polymerase II promoter Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000087510-MONOMER.
ReactomeiR-HSA-3232118. SUMOylation of transcription factors.
R-HSA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-HSA-8866906. TFAP2 (AP-2) family regulates transcription of other transcription factors.
R-HSA-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
R-HSA-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-HSA-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.
SignaLinkiQ92754.

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2 gamma
Short name:
AP2-gamma
Alternative name(s):
Activating enhancer-binding protein 2 gamma
Transcription factor ERF-1
Gene namesi
Name:TFAP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

HGNCiHGNC:11744. TFAP2C.

Subcellular locationi

GO - Cellular componenti

  • mitochondrion Source: HPA
  • nucleoplasm Source: HPA
  • nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59Y → A: Loss of interaction with WWOX; when associated with A-64. 1 Publication1
Mutagenesisi64Y → A: Loss of interaction with WWOX; when associated with A-59. 1 Publication1

Organism-specific databases

DisGeNETi7022.
OpenTargetsiENSG00000087510.
PharmGKBiPA36461.

Polymorphism and mutation databases

BioMutaiTFAP2C.
DMDMi12643310.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001848031 – 450Transcription factor AP-2 gammaAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei252Phosphoserine; by PKABy similarity1
Modified residuei434PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated on Lys-10; which inhibits transcriptional activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92754.
MaxQBiQ92754.
PaxDbiQ92754.
PeptideAtlasiQ92754.
PRIDEiQ92754.

PTM databases

iPTMnetiQ92754.
PhosphoSitePlusiQ92754.

Expressioni

Inductioni

During retinoic acid-mediated differentiation.

Gene expression databases

BgeeiENSG00000087510.
CleanExiHS_TFAP2C.
ExpressionAtlasiQ92754. baseline and differential.
GenevisibleiQ92754. HS.

Organism-specific databases

HPAiCAB016061.
CAB016079.
HPA055179.
HPA057076.

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1.By similarity7 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CITED2Q999672EBI-937309,EBI-937732
UBE2IP632795EBI-937309,EBI-80168

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112880. 17 interactors.
IntActiQ92754. 78 interactors.
STRINGi9606.ENSP00000201031.

Structurei

3D structure databases

ProteinModelPortaliQ92754.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni293 – 424H-S-H (helix-span-helix), dimerizationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 64WW-binding6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 119Gln/Pro-rich (transactivation domain)Add BLAST90

Domaini

The WW-binding motif mediates interaction with WWOX.1 Publication

Sequence similaritiesi

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ92754.
KOiK09177.
OMAiNPLGLPC.
OrthoDBiEOG091G0PR6.
PhylomeDBiQ92754.
TreeFamiTF313718.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
IPR008123. TF_AP2_gamma.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01751. AP2CTNSCPFCT.
PR01748. AP2TNSCPFCT.

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92754-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG
60 70 80 90 100
VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ
110 120 130 140 150
QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL
160 170 180 190 200
PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM
210 220 230 240 250
TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR
260 270 280 290 300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT
310 320 330 340 350
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN
360 370 380 390 400
MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF
410 420 430 440 450
GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK
Length:450
Mass (Da):49,177
Last modified:February 1, 1997 - v1
Checksum:i2D4F5FBC269A34A8
GO
Isoform 2 (identifier: Q92754-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):31,010
Checksum:iA5A874EDB6D7B2BC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565011 – 169Missing in isoform 2. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95693 mRNA. Translation: CAA64989.1.
U85658 mRNA. Translation: AAC51305.1.
AJ315934 Genomic DNA. Translation: CAC86997.1.
AK301572 mRNA. Translation: BAG63065.1.
AL121920 Genomic DNA. Translation: CAC10334.1.
BC035664 mRNA. Translation: AAH35664.2.
BC051829 mRNA. Translation: AAH51829.2.
AB041717 Genomic DNA. Translation: BAC11805.1.
CCDSiCCDS13454.1. [Q92754-1]
RefSeqiNP_003213.1. NM_003222.3. [Q92754-1]
UniGeneiHs.473152.

Genome annotation databases

EnsembliENST00000201031; ENSP00000201031; ENSG00000087510. [Q92754-1]
GeneIDi7022.
KEGGihsa:7022.
UCSCiuc002xya.4. human. [Q92754-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Web resourcesi

Wikipedia

Activating protein 2 entry

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95693 mRNA. Translation: CAA64989.1.
U85658 mRNA. Translation: AAC51305.1.
AJ315934 Genomic DNA. Translation: CAC86997.1.
AK301572 mRNA. Translation: BAG63065.1.
AL121920 Genomic DNA. Translation: CAC10334.1.
BC035664 mRNA. Translation: AAH35664.2.
BC051829 mRNA. Translation: AAH51829.2.
AB041717 Genomic DNA. Translation: BAC11805.1.
CCDSiCCDS13454.1. [Q92754-1]
RefSeqiNP_003213.1. NM_003222.3. [Q92754-1]
UniGeneiHs.473152.

3D structure databases

ProteinModelPortaliQ92754.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112880. 17 interactors.
IntActiQ92754. 78 interactors.
STRINGi9606.ENSP00000201031.

PTM databases

iPTMnetiQ92754.
PhosphoSitePlusiQ92754.

Polymorphism and mutation databases

BioMutaiTFAP2C.
DMDMi12643310.

Proteomic databases

EPDiQ92754.
MaxQBiQ92754.
PaxDbiQ92754.
PeptideAtlasiQ92754.
PRIDEiQ92754.

Protocols and materials databases

DNASUi7022.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000201031; ENSP00000201031; ENSG00000087510. [Q92754-1]
GeneIDi7022.
KEGGihsa:7022.
UCSCiuc002xya.4. human. [Q92754-1]

Organism-specific databases

CTDi7022.
DisGeNETi7022.
GeneCardsiTFAP2C.
HGNCiHGNC:11744. TFAP2C.
HPAiCAB016061.
CAB016079.
HPA055179.
HPA057076.
MIMi601602. gene.
neXtProtiNX_Q92754.
OpenTargetsiENSG00000087510.
PharmGKBiPA36461.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG3811. Eukaryota.
ENOG410XR9E. LUCA.
GeneTreeiENSGT00550000074577.
HOGENOMiHOG000231737.
HOVERGENiHBG002455.
InParanoidiQ92754.
KOiK09177.
OMAiNPLGLPC.
OrthoDBiEOG091G0PR6.
PhylomeDBiQ92754.
TreeFamiTF313718.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000087510-MONOMER.
ReactomeiR-HSA-3232118. SUMOylation of transcription factors.
R-HSA-8866904. Negative regulation of activity of TFAP2 (AP-2) family transcription factors.
R-HSA-8866906. TFAP2 (AP-2) family regulates transcription of other transcription factors.
R-HSA-8866907. Activation of the TFAP2 (AP-2) family of transcription factors.
R-HSA-8866910. TFAP2 (AP-2) family regulates transcription of growth factors and their receptors.
R-HSA-8866911. TFAP2 (AP-2) family regulates transcription of cell cycle factors.
SignaLinkiQ92754.

Miscellaneous databases

GeneWikiiTFAP2C.
GenomeRNAii7022.
PROiQ92754.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000087510.
CleanExiHS_TFAP2C.
ExpressionAtlasiQ92754. baseline and differential.
GenevisibleiQ92754. HS.

Family and domain databases

InterProiIPR004979. TF_AP2.
IPR013854. TF_AP2_C.
IPR008123. TF_AP2_gamma.
[Graphical view]
PANTHERiPTHR10812. PTHR10812. 1 hit.
PfamiPF03299. TF_AP-2. 1 hit.
[Graphical view]
PRINTSiPR01751. AP2CTNSCPFCT.
PR01748. AP2TNSCPFCT.
ProtoNetiSearch...

Entry informationi

Entry nameiAP2C_HUMAN
AccessioniPrimary (citable) accession number: Q92754
Secondary accession number(s): B4DWK3
, O00685, O00730, Q86V30, Q8IVB6, Q9P1X2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 1, 1997
Last modified: November 2, 2016
This is version 160 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.