Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Transcription factor AP-2 gamma

Gene

TFAP2C

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Sequence-specific DNA-binding protein that interacts with inducible viral and cellular enhancer elements to regulate transcription of selected genes. AP-2 factors bind to the consensus sequence 5'-GCCNNNGGC-3' and activate genes involved in a large spectrum of important biological functions including proper eye, face, body wall, limb and neural tube development. They also suppress a number of genes including MCAM/MUC18, C/EBP alpha and MYC. Involved in the MTA1-mediated epigenetic regulation of ESR1 expression in breast cancer.2 Publications

GO - Molecular functioni

GO - Biological processi

  • cell-cell signaling Source: ProtInc
  • male gonad development Source: UniProtKB
  • negative regulation of transcription by RNA polymerase II Source: Reactome
  • positive regulation of transcription by RNA polymerase II Source: BHF-UCL
  • regulation of cell proliferation Source: GO_Central
  • regulation of gene expression, epigenetic Source: UniProtKB
  • regulation of transcription by RNA polymerase II Source: Reactome

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-3232118 SUMOylation of transcription factors
R-HSA-8866904 Negative regulation of activity of TFAP2 (AP-2) family transcription factors
R-HSA-8866906 TFAP2 (AP-2) family regulates transcription of other transcription factors
R-HSA-8866907 Activation of the TFAP2 (AP-2) family of transcription factors
R-HSA-8866910 TFAP2 (AP-2) family regulates transcription of growth factors and their receptors
R-HSA-8866911 TFAP2 (AP-2) family regulates transcription of cell cycle factors
SignaLinkiQ92754
SIGNORiQ92754

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor AP-2 gamma
Short name:
AP2-gamma
Alternative name(s):
Activating enhancer-binding protein 2 gamma
Transcription factor ERF-1
Gene namesi
Name:TFAP2C
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 20

Organism-specific databases

EuPathDBiHostDB:ENSG00000087510.6
HGNCiHGNC:11744 TFAP2C
MIMi601602 gene
neXtProtiNX_Q92754

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi59Y → A: Loss of interaction with WWOX; when associated with A-64. 1 Publication1
Mutagenesisi64Y → A: Loss of interaction with WWOX; when associated with A-59. 1 Publication1

Organism-specific databases

DisGeNETi7022
OpenTargetsiENSG00000087510
PharmGKBiPA36461

Polymorphism and mutation databases

BioMutaiTFAP2C
DMDMi12643310

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001848031 – 450Transcription factor AP-2 gammaAdd BLAST450

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Cross-linki10Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO)1 Publication
Modified residuei252Phosphoserine; by PKABy similarity1
Modified residuei434PhosphoserineCombined sources1

Post-translational modificationi

Sumoylated on Lys-10; which inhibits transcriptional activity.1 Publication

Keywords - PTMi

Isopeptide bond, Phosphoprotein, Ubl conjugation

Proteomic databases

EPDiQ92754
MaxQBiQ92754
PaxDbiQ92754
PeptideAtlasiQ92754
PRIDEiQ92754

PTM databases

iPTMnetiQ92754
PhosphoSitePlusiQ92754

Expressioni

Inductioni

During retinoic acid-mediated differentiation.

Gene expression databases

BgeeiENSG00000087510
CleanExiHS_TFAP2C
ExpressionAtlasiQ92754 baseline and differential
GenevisibleiQ92754 HS

Organism-specific databases

HPAiCAB016061
CAB016079
HPA055179
HPA057076

Interactioni

Subunit structurei

Binds DNA as a dimer. Can form homodimers or heterodimers with other AP-2 family members (By similarity). Interacts with WWOX. Interacts with CITED4. Interacts with UBE2I. Interacts with KCTD1; this interaction represses transcription activation. Interacts with CITED2 (via C-terminus); the interaction stimulates TFAP2B-transcriptional activity. Interacts with MTA1.By similarity7 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • protein dimerization activity Source: UniProtKB

Protein-protein interaction databases

BioGridi112880, 17 interactors
CORUMiQ92754
ELMiQ92754
IntActiQ92754, 78 interactors
STRINGi9606.ENSP00000201031

Structurei

3D structure databases

ProteinModelPortaliQ92754
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni293 – 424H-S-H (helix-span-helix), dimerizationAdd BLAST132

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi59 – 64PPxY motif6

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi30 – 119Gln/Pro-rich (transactivation domain)Add BLAST90

Domaini

The PPxY motif mediates interaction with WWOX.1 Publication

Sequence similaritiesi

Belongs to the AP-2 family.Curated

Phylogenomic databases

eggNOGiKOG3811 Eukaryota
ENOG410XR9E LUCA
GeneTreeiENSGT00550000074577
HOGENOMiHOG000231737
HOVERGENiHBG002455
InParanoidiQ92754
KOiK09177
OMAiRPHVERN
OrthoDBiEOG091G0PR6
PhylomeDBiQ92754
TreeFamiTF313718

Family and domain databases

InterProiView protein in InterPro
IPR004979 TF_AP2
IPR013854 TF_AP2_C
IPR008123 TF_AP2_gamma
PANTHERiPTHR10812 PTHR10812, 1 hit
PfamiView protein in Pfam
PF03299 TF_AP-2, 1 hit
PRINTSiPR01751 AP2CTNSCPFCT
PR01748 AP2TNSCPFCT

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92754-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MLWKITDNVK YEEDCEDRHD GSSNGNPRVP HLSSAGQHLY SPAPPLSHTG
60 70 80 90 100
VAEYQPPPYF PPPYQQLAYS QSADPYSHLG EAYAAAINPL HQPAPTGSQQ
110 120 130 140 150
QAWPGRQSQE GAGLPSHHGR PAGLLPHLSG LEAGAVSARR DAYRRSDLLL
160 170 180 190 200
PHAHALDAAG LAENLGLHDM PHQMDEVQNV DDQHLLLHDQ TVIRKGPISM
210 220 230 240 250
TKNPLNLPCQ KELVGAVMNP TEVFCSVPGR LSLLSSTSKY KVTVAEVQRR
260 270 280 290 300
LSPPECLNAS LLGGVLRRAK SKNGGRSLRE KLDKIGLNLP AGRRKAAHVT
310 320 330 340 350
LLTSLVEGEA VHLARDFAYV CEAEFPSKPV AEYLTRPHLG GRNEMAARKN
360 370 380 390 400
MLLAAQQLCK EFTELLSQDR TPHGTSRLAP VLETNIQNCL SHFSLITHGF
410 420 430 440 450
GSQAICAAVS ALQNYIKEAL IVIDKSYMNP GDQSPADSNK TLEKMEKHRK
Length:450
Mass (Da):49,177
Last modified:February 1, 1997 - v1
Checksum:i2D4F5FBC269A34A8
GO
Isoform 2 (identifier: Q92754-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-169: Missing.

Note: No experimental confirmation available.
Show »
Length:281
Mass (Da):31,010
Checksum:iA5A874EDB6D7B2BC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0565011 – 169Missing in isoform 2. 1 PublicationAdd BLAST169

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X95693 mRNA Translation: CAA64989.1
U85658 mRNA Translation: AAC51305.1
AJ315934 Genomic DNA Translation: CAC86997.1
AK301572 mRNA Translation: BAG63065.1
AL121920 Genomic DNA No translation available.
BC035664 mRNA Translation: AAH35664.2
BC051829 mRNA Translation: AAH51829.2
AB041717 Genomic DNA Translation: BAC11805.1
CCDSiCCDS13454.1 [Q92754-1]
RefSeqiNP_003213.1, NM_003222.3 [Q92754-1]
UniGeneiHs.473152

Genome annotation databases

EnsembliENST00000201031; ENSP00000201031; ENSG00000087510 [Q92754-1]
GeneIDi7022
KEGGihsa:7022
UCSCiuc002xya.4 human [Q92754-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiAP2C_HUMAN
AccessioniPrimary (citable) accession number: Q92754
Secondary accession number(s): B4DWK3
, O00685, O00730, Q86V30, Q8IVB6, Q9P1X2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 24, 2001
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 169 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 20
    Human chromosome 20: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.

Do not show this banner again
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health