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Protein

Nuclear receptor ROR-beta

Gene

RORB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).By similarity
Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi18 – 93Nuclear receptorPROSITE-ProRule annotationAdd BLAST76
Zinc fingeri21 – 41NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri57 – 81NR C4-typePROSITE-ProRule annotationAdd BLAST25

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Receptor

Keywords - Biological processi

Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

BioCyciZFISH:G66-30731-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor ROR-beta
Alternative name(s):
Nuclear receptor RZR-beta
Nuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta
Gene namesi
Name:RORB
Synonyms:NR1F2, RZRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 9

Organism-specific databases

HGNCiHGNC:10259. RORB.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi6096.
OpenTargetsiENSG00000198963.
PharmGKBiPA34631.

Chemistry databases

ChEMBLiCHEMBL3091268.
DrugBankiDB01065. Melatonin.
GuidetoPHARMACOLOGYi599.

Polymorphism and mutation databases

DMDMi124028630.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000535141 – 470Nuclear receptor ROR-betaAdd BLAST470

Proteomic databases

PaxDbiQ92753.
PeptideAtlasiQ92753.
PRIDEiQ92753.

PTM databases

iPTMnetiQ92753.
PhosphoSitePlusiQ92753.

Expressioni

Gene expression databases

BgeeiENSG00000198963.
CleanExiHS_RORB.
ExpressionAtlasiQ92753. baseline and differential.
GenevisibleiQ92753. HS.

Organism-specific databases

HPAiHPA008393.

Interactioni

Subunit structurei

Monomer. Interacts with CRX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ClockO087852EBI-6144615,EBI-79859From a different organism.

Protein-protein interaction databases

IntActiQ92753. 4 interactors.
STRINGi9606.ENSP00000366093.

Chemistry databases

BindingDBiQ92753.

Structurei

3D structure databases

ProteinModelPortaliQ92753.
SMRiQ92753.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni94 – 221HingeSequence analysisAdd BLAST128
Regioni222 – 470Ligand-bindingSequence analysisAdd BLAST249

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi456 – 461AF-26

Domaini

AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Zinc fingeri21 – 41NR C4-typePROSITE-ProRule annotationAdd BLAST21
Zinc fingeri57 – 81NR C4-typePROSITE-ProRule annotationAdd BLAST25

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000010200.
HOVERGENiHBG106848.
InParanoidiQ92753.
OMAiCTLHTEE.
OrthoDBiEOG091G0649.
PhylomeDBiQ92753.
TreeFamiTF319910.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 2 (identifier: Q92753-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ
60 70 80 90 100
NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ
110 120 130 140 150
RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNNETSG
160 170 180 190 200
TYANGHVIDL PKSEGYYNVD SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV
210 220 230 240 250
PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY TMEELHQLAW
260 270 280 290 300
QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN
310 320 330 340 350
DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV
360 370 380 390 400
NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY
410 420 430 440 450
FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPEIVN
460 470
TLFPPLYKEL FNPDCATGCK
Length:470
Mass (Da):53,220
Last modified:January 23, 2007 - v3
Checksum:iF41FAF95FA5E7100
GO
Isoform 1 (identifier: Q92753-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MCENQLKTKADAT → MR

Show »
Length:459
Mass (Da):52,073
Checksum:iE15FD91422CCD67C
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti121Q → E in CAA69929 (Ref. 1) Curated1
Sequence conflicti128A → R in CAA69929 (Ref. 1) Curated1
Sequence conflicti156H → S in CAA69929 (Ref. 1) Curated1
Sequence conflicti170D → V in CAA69929 (Ref. 1) Curated1
Sequence conflicti468G → A in CAA69929 (Ref. 1) Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_0225751 – 13MCENQ…KADAT → MR in isoform 1. 1 PublicationAdd BLAST13

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08639 mRNA. Translation: CAA69929.1.
BX647070 mRNA. No translation available.
AL137018 Genomic DNA. Translation: CAD13276.2.
CCDSiCCDS6646.1. [Q92753-1]
UniGeneiHs.494178.

Genome annotation databases

EnsembliENST00000376896; ENSP00000366093; ENSG00000198963. [Q92753-1]
ENST00000396204; ENSP00000379507; ENSG00000198963. [Q92753-2]
UCSCiuc004ajh.4. human. [Q92753-2]

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08639 mRNA. Translation: CAA69929.1.
BX647070 mRNA. No translation available.
AL137018 Genomic DNA. Translation: CAD13276.2.
CCDSiCCDS6646.1. [Q92753-1]
UniGeneiHs.494178.

3D structure databases

ProteinModelPortaliQ92753.
SMRiQ92753.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ92753. 4 interactors.
STRINGi9606.ENSP00000366093.

Chemistry databases

BindingDBiQ92753.
ChEMBLiCHEMBL3091268.
DrugBankiDB01065. Melatonin.
GuidetoPHARMACOLOGYi599.

PTM databases

iPTMnetiQ92753.
PhosphoSitePlusiQ92753.

Polymorphism and mutation databases

DMDMi124028630.

Proteomic databases

PaxDbiQ92753.
PeptideAtlasiQ92753.
PRIDEiQ92753.

Protocols and materials databases

DNASUi6096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376896; ENSP00000366093; ENSG00000198963. [Q92753-1]
ENST00000396204; ENSP00000379507; ENSG00000198963. [Q92753-2]
UCSCiuc004ajh.4. human. [Q92753-2]

Organism-specific databases

DisGeNETi6096.
GeneCardsiRORB.
HGNCiHGNC:10259. RORB.
HPAiHPA008393.
MIMi601972. gene.
neXtProtiNX_Q92753.
OpenTargetsiENSG00000198963.
PharmGKBiPA34631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG4216. Eukaryota.
ENOG410XUGR. LUCA.
GeneTreeiENSGT00850000132242.
HOGENOMiHOG000010200.
HOVERGENiHBG106848.
InParanoidiQ92753.
OMAiCTLHTEE.
OrthoDBiEOG091G0649.
PhylomeDBiQ92753.
TreeFamiTF319910.

Enzyme and pathway databases

BioCyciZFISH:G66-30731-MONOMER.
ReactomeiR-HSA-383280. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiRORB. human.
PROiQ92753.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000198963.
CleanExiHS_RORB.
ExpressionAtlasiQ92753. baseline and differential.
GenevisibleiQ92753. HS.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR000536. Nucl_hrmn_rcpt_lig-bd.
IPR001723. Nuclear_hrmn_rcpt.
IPR003079. ROR_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRORB_HUMAN
AccessioniPrimary (citable) accession number: Q92753
Secondary accession number(s): Q8WX73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: November 2, 2016
This is version 152 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.