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Q92753

- RORB_HUMAN

UniProt

Q92753 - RORB_HUMAN

Protein

Nuclear receptor ROR-beta

Gene

RORB

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 133 (01 Oct 2014)
      Sequence version 3 (23 Jan 2007)
      Previous versions | rss
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    Functioni

    Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity By similarity.By similarity
    Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 By similarity.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi18 – 9376Nuclear receptorPROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri21 – 4121NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri57 – 8125NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
    2. protein binding Source: IntAct
    3. sequence-specific DNA binding Source: Ensembl
    4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
    5. steroid hormone receptor activity Source: InterPro
    6. zinc ion binding Source: InterPro

    GO - Biological processi

    1. amacrine cell differentiation Source: UniProtKB
    2. cellular response to retinoic acid Source: UniProtKB
    3. eye photoreceptor cell development Source: UniProtKB
    4. gene expression Source: Reactome
    5. intracellular receptor signaling pathway Source: GOC
    6. negative regulation of osteoblast differentiation Source: UniProtKB
    7. negative regulation of transcription, DNA-templated Source: UniProtKB
    8. positive regulation of transcription, DNA-templated Source: UniProtKB
    9. regulation of circadian rhythm Source: UniProtKB
    10. regulation of transcription, DNA-templated Source: ProtInc
    11. retina development in camera-type eye Source: UniProtKB
    12. retinal cone cell development Source: UniProtKB
    13. retinal rod cell development Source: UniProtKB
    14. rhythmic process Source: UniProtKB-KW
    15. transcription initiation from RNA polymerase II promoter Source: Reactome
    16. visual perception Source: UniProtKB-KW

    Keywords - Molecular functioni

    Activator, Developmental protein, Receptor

    Keywords - Biological processi

    Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision

    Keywords - Ligandi

    DNA-binding, Metal-binding, Zinc

    Enzyme and pathway databases

    ReactomeiREACT_15525. Nuclear Receptor transcription pathway.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nuclear receptor ROR-beta
    Alternative name(s):
    Nuclear receptor RZR-beta
    Nuclear receptor subfamily 1 group F member 2
    Retinoid-related orphan receptor-beta
    Gene namesi
    Name:RORB
    Synonyms:NR1F2, RZRB
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 9

    Organism-specific databases

    HGNCiHGNC:10259. RORB.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleoplasm Source: Reactome
    2. nucleus Source: UniProtKB

    Keywords - Cellular componenti

    Nucleus

    Pathology & Biotechi

    Organism-specific databases

    PharmGKBiPA34631.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 470470Nuclear receptor ROR-betaPRO_0000053514Add
    BLAST

    Proteomic databases

    PaxDbiQ92753.
    PRIDEiQ92753.

    PTM databases

    PhosphoSiteiQ92753.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92753.
    BgeeiQ92753.
    CleanExiHS_RORB.
    GenevestigatoriQ92753.

    Organism-specific databases

    HPAiHPA008393.

    Interactioni

    Subunit structurei

    Monomer. Interacts with CRX By similarity.By similarity

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ClockO087852EBI-6144615,EBI-79859From a different organism.

    Protein-protein interaction databases

    BioGridi112023. 12 interactions.
    IntActiQ92753. 4 interactions.
    STRINGi9606.ENSP00000366093.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92753.
    SMRiQ92753. Positions 9-463.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni94 – 221128HingeSequence AnalysisAdd
    BLAST
    Regioni222 – 470249Ligand-bindingSequence AnalysisAdd
    BLAST

    Motif

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Motifi456 – 4616AF-2

    Domaini

    AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity.By similarity

    Sequence similaritiesi

    Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

    Zinc finger

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Zinc fingeri21 – 4121NR C4-typePROSITE-ProRule annotationAdd
    BLAST
    Zinc fingeri57 – 8125NR C4-typePROSITE-ProRule annotationAdd
    BLAST

    Keywords - Domaini

    Zinc-finger

    Phylogenomic databases

    eggNOGiNOG324222.
    HOGENOMiHOG000010200.
    HOVERGENiHBG106848.
    InParanoidiQ92753.
    OMAiWEQLHDY.
    OrthoDBiEOG79PJNW.
    PhylomeDBiQ92753.
    TreeFamiTF319910.

    Family and domain databases

    Gene3Di1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003079. ROR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view]
    PfamiPF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view]
    PRINTSiPR01293. RORNUCRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTiSM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view]
    SUPFAMiSSF48508. SSF48508. 1 hit.
    PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative promoter usage. Align

    Isoform 2 (identifier: Q92753-2) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ    50
    NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ 100
    RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNNETSG 150
    TYANGHVIDL PKSEGYYNVD SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV 200
    PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY TMEELHQLAW 250
    QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN 300
    DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV 350
    NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY 400
    FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPEIVN 450
    TLFPPLYKEL FNPDCATGCK 470
    Length:470
    Mass (Da):53,220
    Last modified:January 23, 2007 - v3
    Checksum:iF41FAF95FA5E7100
    GO
    Isoform 1 (identifier: Q92753-1) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-13: MCENQLKTKADAT → MR

    Show »
    Length:459
    Mass (Da):52,073
    Checksum:iE15FD91422CCD67C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti121 – 1211Q → E in CAA69929. 1 PublicationCurated
    Sequence conflicti128 – 1281A → R in CAA69929. 1 PublicationCurated
    Sequence conflicti156 – 1561H → S in CAA69929. 1 PublicationCurated
    Sequence conflicti170 – 1701D → V in CAA69929. 1 PublicationCurated
    Sequence conflicti468 – 4681G → A in CAA69929. 1 PublicationCurated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 1313MCENQ…KADAT → MR in isoform 1. 1 PublicationVSP_022575Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08639 mRNA. Translation: CAA69929.1.
    BX647070 mRNA. No translation available.
    AL137018 Genomic DNA. Translation: CAD13276.2.
    CCDSiCCDS6646.1. [Q92753-1]
    UniGeneiHs.494178.

    Genome annotation databases

    EnsembliENST00000376896; ENSP00000366093; ENSG00000198963. [Q92753-1]
    ENST00000396204; ENSP00000379507; ENSG00000198963. [Q92753-2]
    UCSCiuc004aji.3. human. [Q92753-2]

    Polymorphism databases

    DMDMi124028630.

    Keywords - Coding sequence diversityi

    Alternative promoter usage

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y08639 mRNA. Translation: CAA69929.1 .
    BX647070 mRNA. No translation available.
    AL137018 Genomic DNA. Translation: CAD13276.2 .
    CCDSi CCDS6646.1. [Q92753-1 ]
    UniGenei Hs.494178.

    3D structure databases

    ProteinModelPortali Q92753.
    SMRi Q92753. Positions 9-463.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 112023. 12 interactions.
    IntActi Q92753. 4 interactions.
    STRINGi 9606.ENSP00000366093.

    Chemistry

    GuidetoPHARMACOLOGYi 599.

    PTM databases

    PhosphoSitei Q92753.

    Polymorphism databases

    DMDMi 124028630.

    Proteomic databases

    PaxDbi Q92753.
    PRIDEi Q92753.

    Protocols and materials databases

    DNASUi 6096.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000376896 ; ENSP00000366093 ; ENSG00000198963 . [Q92753-1 ]
    ENST00000396204 ; ENSP00000379507 ; ENSG00000198963 . [Q92753-2 ]
    UCSCi uc004aji.3. human. [Q92753-2 ]

    Organism-specific databases

    GeneCardsi GC09P077112.
    HGNCi HGNC:10259. RORB.
    HPAi HPA008393.
    MIMi 601972. gene.
    neXtProti NX_Q92753.
    PharmGKBi PA34631.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG324222.
    HOGENOMi HOG000010200.
    HOVERGENi HBG106848.
    InParanoidi Q92753.
    OMAi WEQLHDY.
    OrthoDBi EOG79PJNW.
    PhylomeDBi Q92753.
    TreeFami TF319910.

    Enzyme and pathway databases

    Reactomei REACT_15525. Nuclear Receptor transcription pathway.

    Miscellaneous databases

    ChiTaRSi RORB. human.
    NextBioi 23713.
    PROi Q92753.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92753.
    Bgeei Q92753.
    CleanExi HS_RORB.
    Genevestigatori Q92753.

    Family and domain databases

    Gene3Di 1.10.565.10. 2 hits.
    3.30.50.10. 1 hit.
    InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
    IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
    IPR003079. ROR_rcpt.
    IPR001723. Str_hrmn_rcpt.
    IPR001628. Znf_hrmn_rcpt.
    IPR013088. Znf_NHR/GATA.
    [Graphical view ]
    Pfami PF00104. Hormone_recep. 1 hit.
    PF00105. zf-C4. 1 hit.
    [Graphical view ]
    PRINTSi PR01293. RORNUCRECPTR.
    PR00398. STRDHORMONER.
    PR00047. STROIDFINGER.
    SMARTi SM00430. HOLI. 1 hit.
    SM00399. ZnF_C4. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48508. SSF48508. 1 hit.
    PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
    PS51030. NUCLEAR_REC_DBD_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Becker-Andre M.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Retina.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Retina.
    3. "DNA sequence and analysis of human chromosome 9."
      Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
      , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
      Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

    Entry informationi

    Entry nameiRORB_HUMAN
    AccessioniPrimary (citable) accession number: Q92753
    Secondary accession number(s): Q8WX73
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: January 23, 2007
    Last modified: October 1, 2014
    This is version 133 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 9
      Human chromosome 9: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3