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Protein

Nuclear receptor ROR-beta

Gene

RORB

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity (By similarity).By similarity
Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 (By similarity).By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi18 – 9376Nuclear receptorPROSITE-ProRule annotationAdd
BLAST
Zinc fingeri21 – 4121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri57 – 8125NR C4-typePROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
  2. sequence-specific DNA binding Source: Ensembl
  3. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  4. steroid hormone receptor activity Source: InterPro
  5. zinc ion binding Source: InterPro

GO - Biological processi

  1. amacrine cell differentiation Source: UniProtKB
  2. cellular response to retinoic acid Source: UniProtKB
  3. eye photoreceptor cell development Source: UniProtKB
  4. gene expression Source: Reactome
  5. intracellular receptor signaling pathway Source: GOC
  6. negative regulation of osteoblast differentiation Source: UniProtKB
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of transcription, DNA-templated Source: UniProtKB
  9. regulation of circadian rhythm Source: UniProtKB
  10. regulation of transcription, DNA-templated Source: ProtInc
  11. retina development in camera-type eye Source: UniProtKB
  12. retinal cone cell development Source: UniProtKB
  13. retinal rod cell development Source: UniProtKB
  14. rhythmic process Source: UniProtKB-KW
  15. transcription initiation from RNA polymerase II promoter Source: Reactome
  16. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Receptor

Keywords - Biological processi

Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor ROR-beta
Alternative name(s):
Nuclear receptor RZR-beta
Nuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta
Gene namesi
Name:RORB
Synonyms:NR1F2, RZRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:10259. RORB.

Subcellular locationi

Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Nuclear receptor ROR-betaPRO_0000053514Add
BLAST

Proteomic databases

PaxDbiQ92753.
PRIDEiQ92753.

PTM databases

PhosphoSiteiQ92753.

Expressioni

Gene expression databases

BgeeiQ92753.
CleanExiHS_RORB.
ExpressionAtlasiQ92753. baseline and differential.
GenevestigatoriQ92753.

Organism-specific databases

HPAiHPA008393.

Interactioni

Subunit structurei

Monomer. Interacts with CRX (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
ClockO087852EBI-6144615,EBI-79859From a different organism.

Protein-protein interaction databases

BioGridi112023. 14 interactions.
IntActiQ92753. 4 interactions.
STRINGi9606.ENSP00000366093.

Structurei

3D structure databases

ProteinModelPortaliQ92753.
SMRiQ92753. Positions 19-139, 219-462.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 221128HingeSequence AnalysisAdd
BLAST
Regioni222 – 470249Ligand-bindingSequence AnalysisAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi456 – 4616AF-2

Domaini

AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity.By similarity

Sequence similaritiesi

Contains 1 nuclear receptor DNA-binding domain.PROSITE-ProRule annotation

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri21 – 4121NR C4-typePROSITE-ProRule annotationAdd
BLAST
Zinc fingeri57 – 8125NR C4-typePROSITE-ProRule annotationAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG324222.
GeneTreeiENSGT00780000121834.
HOGENOMiHOG000010200.
HOVERGENiHBG106848.
InParanoidiQ92753.
OMAiWEQLHDY.
OrthoDBiEOG79PJNW.
PhylomeDBiQ92753.
TreeFamiTF319910.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. AlignAdd to basket

Isoform 2 (identifier: Q92753-2) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ
60 70 80 90 100
NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ
110 120 130 140 150
RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNNETSG
160 170 180 190 200
TYANGHVIDL PKSEGYYNVD SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV
210 220 230 240 250
PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY TMEELHQLAW
260 270 280 290 300
QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN
310 320 330 340 350
DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV
360 370 380 390 400
NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY
410 420 430 440 450
FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPEIVN
460 470
TLFPPLYKEL FNPDCATGCK
Length:470
Mass (Da):53,220
Last modified:January 23, 2007 - v3
Checksum:iF41FAF95FA5E7100
GO
Isoform 1 (identifier: Q92753-1) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MCENQLKTKADAT → MR

Show »
Length:459
Mass (Da):52,073
Checksum:iE15FD91422CCD67C
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211Q → E in CAA69929 (Ref. 1) Curated
Sequence conflicti128 – 1281A → R in CAA69929 (Ref. 1) Curated
Sequence conflicti156 – 1561H → S in CAA69929 (Ref. 1) Curated
Sequence conflicti170 – 1701D → V in CAA69929 (Ref. 1) Curated
Sequence conflicti468 – 4681G → A in CAA69929 (Ref. 1) Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MCENQ…KADAT → MR in isoform 1. 1 PublicationVSP_022575Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08639 mRNA. Translation: CAA69929.1.
BX647070 mRNA. No translation available.
AL137018 Genomic DNA. Translation: CAD13276.2.
CCDSiCCDS6646.1. [Q92753-1]
UniGeneiHs.494178.

Genome annotation databases

EnsembliENST00000376896; ENSP00000366093; ENSG00000198963. [Q92753-1]
ENST00000396204; ENSP00000379507; ENSG00000198963. [Q92753-2]
UCSCiuc004aji.3. human. [Q92753-2]

Polymorphism databases

DMDMi124028630.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08639 mRNA. Translation: CAA69929.1.
BX647070 mRNA. No translation available.
AL137018 Genomic DNA. Translation: CAD13276.2.
CCDSiCCDS6646.1. [Q92753-1]
UniGeneiHs.494178.

3D structure databases

ProteinModelPortaliQ92753.
SMRiQ92753. Positions 19-139, 219-462.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112023. 14 interactions.
IntActiQ92753. 4 interactions.
STRINGi9606.ENSP00000366093.

Chemistry

BindingDBiQ92753.
ChEMBLiCHEMBL3091268.
DrugBankiDB01065. Melatonin.
GuidetoPHARMACOLOGYi599.

PTM databases

PhosphoSiteiQ92753.

Polymorphism databases

DMDMi124028630.

Proteomic databases

PaxDbiQ92753.
PRIDEiQ92753.

Protocols and materials databases

DNASUi6096.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000376896; ENSP00000366093; ENSG00000198963. [Q92753-1]
ENST00000396204; ENSP00000379507; ENSG00000198963. [Q92753-2]
UCSCiuc004aji.3. human. [Q92753-2]

Organism-specific databases

GeneCardsiGC09P077112.
HGNCiHGNC:10259. RORB.
HPAiHPA008393.
MIMi601972. gene.
neXtProtiNX_Q92753.
PharmGKBiPA34631.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG324222.
GeneTreeiENSGT00780000121834.
HOGENOMiHOG000010200.
HOVERGENiHBG106848.
InParanoidiQ92753.
OMAiWEQLHDY.
OrthoDBiEOG79PJNW.
PhylomeDBiQ92753.
TreeFamiTF319910.

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSiRORB. human.
NextBioi23713.
PROiQ92753.
SOURCEiSearch...

Gene expression databases

BgeeiQ92753.
CleanExiHS_RORB.
ExpressionAtlasiQ92753. baseline and differential.
GenevestigatoriQ92753.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Becker-Andre M.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRORB_HUMAN
AccessioniPrimary (citable) accession number: Q92753
Secondary accession number(s): Q8WX73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: March 4, 2015
This is version 137 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.