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Q92753

- RORB_HUMAN

UniProt

Q92753 - RORB_HUMAN

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Protein
Nuclear receptor ROR-beta
Gene
RORB, NR1F2, RZRB
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Nuclear receptor that binds DNA as a monomer to ROR response elements (RORE) containing a single core motif half-site 5'-AGGTCA-3' preceded by a short A-T-rich sequence. Considered to have intrinsic transcriptional activity, have some natural ligands such as all-trans retinoic acid (ATRA) and other retinoids which act as inverse agonists repressing the transcriptional activity. Required for normal postnatal development of rod and cone photoreceptor cells. Modulates rod photoreceptors differentiation at least by inducing the transcription factor NRL-mediated pathway. In cone photoreceptor cells, regulates transcription of OPN1SW. Involved in the regulation of the period length and stability of the circadian rhythm. May control cytoarchitectural patterning of neocortical neurons during development. May act in a dose-dependent manner to regulate barrel formation upon innervation of layer IV neurons by thalamocortical axons. May play a role in the suppression of osteoblastic differentiation through the inhibition of RUNX2 transcriptional activity By similarity.
Isoform 1 is critical for hindlimb motor control and for the differentiation of amacrine and horizontal cells in the retina. Regulates the expression of PTF1A synergistically with FOXN4 By similarity.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi18 – 9376Nuclear receptor
Add
BLAST
Zinc fingeri21 – 4121NR C4-type
Add
BLAST
Zinc fingeri57 – 8125NR C4-type
Add
BLAST

GO - Molecular functioni

  1. ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Source: ProtInc
  2. protein binding Source: IntAct
  3. sequence-specific DNA binding Source: Ensembl
  4. sequence-specific DNA binding transcription factor activity Source: UniProtKB
  5. steroid hormone receptor activity Source: InterPro
  6. zinc ion binding Source: InterPro

GO - Biological processi

  1. amacrine cell differentiation Source: UniProtKB
  2. cellular response to retinoic acid Source: UniProtKB
  3. eye photoreceptor cell development Source: UniProtKB
  4. gene expression Source: Reactome
  5. intracellular receptor signaling pathway Source: GOC
  6. negative regulation of osteoblast differentiation Source: UniProtKB
  7. negative regulation of transcription, DNA-templated Source: UniProtKB
  8. positive regulation of transcription, DNA-templated Source: UniProtKB
  9. regulation of circadian rhythm Source: UniProtKB
  10. regulation of transcription, DNA-templated Source: ProtInc
  11. retina development in camera-type eye Source: UniProtKB
  12. retinal cone cell development Source: UniProtKB
  13. retinal rod cell development Source: UniProtKB
  14. rhythmic process Source: UniProtKB-KW
  15. transcription initiation from RNA polymerase II promoter Source: Reactome
  16. visual perception Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein, Receptor

Keywords - Biological processi

Biological rhythms, Sensory transduction, Transcription, Transcription regulation, Vision

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Enzyme and pathway databases

ReactomeiREACT_15525. Nuclear Receptor transcription pathway.

Names & Taxonomyi

Protein namesi
Recommended name:
Nuclear receptor ROR-beta
Alternative name(s):
Nuclear receptor RZR-beta
Nuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta
Gene namesi
Name:RORB
Synonyms:NR1F2, RZRB
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 9

Organism-specific databases

HGNCiHGNC:10259. RORB.

Subcellular locationi

Nucleus By similarity

GO - Cellular componenti

  1. nucleoplasm Source: Reactome
  2. nucleus Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA34631.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 470470Nuclear receptor ROR-beta
PRO_0000053514Add
BLAST

Proteomic databases

PaxDbiQ92753.
PRIDEiQ92753.

PTM databases

PhosphoSiteiQ92753.

Expressioni

Gene expression databases

ArrayExpressiQ92753.
BgeeiQ92753.
CleanExiHS_RORB.
GenevestigatoriQ92753.

Organism-specific databases

HPAiHPA008393.

Interactioni

Subunit structurei

Monomer. Interacts with CRX By similarity.

Binary interactionsi

WithEntry#Exp.IntActNotes
ClockO087852EBI-6144615,EBI-79859From a different organism.

Protein-protein interaction databases

BioGridi112023. 12 interactions.
IntActiQ92753. 4 interactions.
STRINGi9606.ENSP00000366093.

Structurei

3D structure databases

ProteinModelPortaliQ92753.
SMRiQ92753. Positions 9-463.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni94 – 221128Hinge Reviewed prediction
Add
BLAST
Regioni222 – 470249Ligand-binding Reviewed prediction
Add
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi456 – 4616AF-2

Domaini

AF-2 (activation function-2) motif is required for recruiting coregulators containing the LXXLL motif, such as NCOA1, and control the transactivational activity By similarity.

Sequence similaritiesi

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiNOG324222.
HOGENOMiHOG000010200.
HOVERGENiHBG106848.
InParanoidiQ92753.
OMAiWEQLHDY.
OrthoDBiEOG79PJNW.
PhylomeDBiQ92753.
TreeFamiTF319910.

Family and domain databases

Gene3Di1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProiIPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view]
PfamiPF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view]
PRINTSiPR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTiSM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view]
SUPFAMiSSF48508. SSF48508. 1 hit.
PROSITEiPS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative promoter usage. Align

Isoform 2 (identifier: Q92753-2) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ    50
NNASYSCPRQ RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ 100
RDSLYAEVQK HQQRLQEQRQ QQSGEAEALA RVYSSSISNG LSNLNNETSG 150
TYANGHVIDL PKSEGYYNVD SGQPSPDQSG LDMTGIKQIK QEPIYDLTSV 200
PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY TMEELHQLAW 250
QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN 300
DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV 350
NEAFDFAKNL CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY 400
FALQHVIQKN HLDDETLAKL IAKIPTITAV CNLHGEKLQV FKQSHPEIVN 450
TLFPPLYKEL FNPDCATGCK 470
Length:470
Mass (Da):53,220
Last modified:January 23, 2007 - v3
Checksum:iF41FAF95FA5E7100
GO
Isoform 1 (identifier: Q92753-1) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MCENQLKTKADAT → MR

Show »
Length:459
Mass (Da):52,073
Checksum:iE15FD91422CCD67C
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 1313MCENQ…KADAT → MR in isoform 1.
VSP_022575Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti121 – 1211Q → E in CAA69929. 1 Publication
Sequence conflicti128 – 1281A → R in CAA69929. 1 Publication
Sequence conflicti156 – 1561H → S in CAA69929. 1 Publication
Sequence conflicti170 – 1701D → V in CAA69929. 1 Publication
Sequence conflicti468 – 4681G → A in CAA69929. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08639 mRNA. Translation: CAA69929.1.
BX647070 mRNA. No translation available.
AL137018 Genomic DNA. Translation: CAD13276.2.
CCDSiCCDS6646.1. [Q92753-1]
UniGeneiHs.494178.

Genome annotation databases

EnsembliENST00000376896; ENSP00000366093; ENSG00000198963. [Q92753-1]
ENST00000396204; ENSP00000379507; ENSG00000198963. [Q92753-2]
UCSCiuc004aji.3. human. [Q92753-2]

Polymorphism databases

DMDMi124028630.

Keywords - Coding sequence diversityi

Alternative promoter usage

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y08639 mRNA. Translation: CAA69929.1 .
BX647070 mRNA. No translation available.
AL137018 Genomic DNA. Translation: CAD13276.2 .
CCDSi CCDS6646.1. [Q92753-1 ]
UniGenei Hs.494178.

3D structure databases

ProteinModelPortali Q92753.
SMRi Q92753. Positions 9-463.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 112023. 12 interactions.
IntActi Q92753. 4 interactions.
STRINGi 9606.ENSP00000366093.

Chemistry

GuidetoPHARMACOLOGYi 599.

PTM databases

PhosphoSitei Q92753.

Polymorphism databases

DMDMi 124028630.

Proteomic databases

PaxDbi Q92753.
PRIDEi Q92753.

Protocols and materials databases

DNASUi 6096.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000376896 ; ENSP00000366093 ; ENSG00000198963 . [Q92753-1 ]
ENST00000396204 ; ENSP00000379507 ; ENSG00000198963 . [Q92753-2 ]
UCSCi uc004aji.3. human. [Q92753-2 ]

Organism-specific databases

GeneCardsi GC09P077112.
HGNCi HGNC:10259. RORB.
HPAi HPA008393.
MIMi 601972. gene.
neXtProti NX_Q92753.
PharmGKBi PA34631.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG324222.
HOGENOMi HOG000010200.
HOVERGENi HBG106848.
InParanoidi Q92753.
OMAi WEQLHDY.
OrthoDBi EOG79PJNW.
PhylomeDBi Q92753.
TreeFami TF319910.

Enzyme and pathway databases

Reactomei REACT_15525. Nuclear Receptor transcription pathway.

Miscellaneous databases

ChiTaRSi RORB. human.
NextBioi 23713.
PROi Q92753.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92753.
Bgeei Q92753.
CleanExi HS_RORB.
Genevestigatori Q92753.

Family and domain databases

Gene3Di 1.10.565.10. 2 hits.
3.30.50.10. 1 hit.
InterProi IPR008946. Nucl_hormone_rcpt_ligand-bd.
IPR000536. Nucl_hrmn_rcpt_lig-bd_core.
IPR003079. ROR_rcpt.
IPR001723. Str_hrmn_rcpt.
IPR001628. Znf_hrmn_rcpt.
IPR013088. Znf_NHR/GATA.
[Graphical view ]
Pfami PF00104. Hormone_recep. 1 hit.
PF00105. zf-C4. 1 hit.
[Graphical view ]
PRINTSi PR01293. RORNUCRECPTR.
PR00398. STRDHORMONER.
PR00047. STROIDFINGER.
SMARTi SM00430. HOLI. 1 hit.
SM00399. ZnF_C4. 1 hit.
[Graphical view ]
SUPFAMi SSF48508. SSF48508. 1 hit.
PROSITEi PS00031. NUCLEAR_REC_DBD_1. 1 hit.
PS51030. NUCLEAR_REC_DBD_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Becker-Andre M.
    Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Retina.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Retina.
  3. "DNA sequence and analysis of human chromosome 9."
    Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L.
    , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I.
    Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].

Entry informationi

Entry nameiRORB_HUMAN
AccessioniPrimary (citable) accession number: Q92753
Secondary accession number(s): Q8WX73
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: January 23, 2007
Last modified: September 3, 2014
This is version 132 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 9
    Human chromosome 9: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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