Q92753 (RORB_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Nuclear receptor ROR-beta

Alternative name(s):
Nuclear receptor RZR-beta
Nuclear receptor subfamily 1 group F member 2
Retinoid-related orphan receptor-beta

Gene names

Name:	RORB
Synonyms:	NR1F2, RZRB

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	470 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Orphan nuclear receptor required for normal postnatal development of rod and cone photoreceptor cells. Regulates transcription of OPN1SW in cone photoreceptor cells by binding the sequence 5'-AGGTCA-3' in the OPN1SW promoter By similarity.
Subcellular location	Nucleus Probable.
Sequence similarities	Belongs to the nuclear hormone receptor family. NR1 subfamily. Contains 1 nuclear receptor DNA-binding domain.

Ontologies

Keywords
Biological process	Sensory transduction Transcription Transcription regulation Vision
Cellular component	Nucleus
Coding sequence diversity	Alternative splicing
Domain	Zinc-finger
Ligand	DNA-binding Metal-binding Zinc
Molecular function	Activator Developmental protein Receptor
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	eye photoreceptor cell development Inferred from sequence or structural similarity. Source: UniProtKB positive regulation of transcription, DNA-dependent Inferred from sequence or structural similarity. Source: UniProtKB transcription initiation from RNA polymerase II promoter Traceable author statement. Source: Reactome visual perception Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleoplasm Traceable author statement. Source: Reactome
Molecular_function	ligand-activated sequence-specific DNA binding RNA polymerase II transcription factor activity Traceable author statement PubMed 7935491. Source: ProtInc sequence-specific DNA binding Inferred from sequence or structural similarity. Source: UniProtKB steroid hormone receptor activity Inferred from electronic annotation. Source: InterPro zinc ion binding Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
Clock	O08785	2	EBI-6144615,EBI-79859	From a different organism.

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]

Isoform 2 (identifier: Q92753-2)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

Isoform 1 (identifier: Q92753-1)

The sequence of this isoform differs from the canonical sequence as follows:
     1-13: MCENQLKTKADAT → MR

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 470	470	Nuclear receptor ROR-beta		PRO_0000053514
Regions
	DNA binding	18 – 93	76	Nuclear receptor
	Zinc finger	21 – 41	21	NR C4-type
	Zinc finger	57 – 81	25	NR C4-type
	Region	94 – 221	128	Hinge Potential
	Region	222 – 470	249	Ligand-binding Potential
Natural variations
	Alternative sequence	1 – 13	13	MCENQ…KADAT → MR in isoform 1.		VSP_022575
Experimental info
	Sequence conflict	121	1	Q → E in CAA69929. Ref.1
	Sequence conflict	128	1	A → R in CAA69929. Ref.1
	Sequence conflict	156	1	H → S in CAA69929. Ref.1
	Sequence conflict	170	1	D → V in CAA69929. Ref.1
	Sequence conflict	468	1	G → A in CAA69929. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Isoform 2 [UniParc]. Last modified January 23, 2007. Version 3. Checksum: F41FAF95FA5E7100	FASTA	470	53,220
	10 20 30 40 50 60 MCENQLKTKA DATAQIEVIP CKICGDKSSG IHYGVITCEG CKGFFRRSQQ NNASYSCPRQ 70 80 90 100 110 120 RNCLIDRTNR NRCQHCRLQK CLALGMSRDA VKFGRMSKKQ RDSLYAEVQK HQQRLQEQRQ 130 140 150 160 170 180 QQSGEAEALA RVYSSSISNG LSNLNNETSG TYANGHVIDL PKSEGYYNVD SGQPSPDQSG 190 200 210 220 230 240 LDMTGIKQIK QEPIYDLTSV PNLFTYSSFN NGQLAPGITM TEIDRIAQNI IKSHLETCQY 250 260 270 280 290 300 TMEELHQLAW QTHTYEEIKA YQSKSREALW QQCAIQITHA IQYVVEFAKR ITGFMELCQN 310 320 330 340 350 360 DQILLLKSGC LEVVLVRMCR AFNPLNNTVL FEGKYGGMQM FKALGSDDLV NEAFDFAKNL 370 380 390 400 410 420 CSLQLTEEEI ALFSSAVLIS PDRAWLIEPR KVQKLQEKIY FALQHVIQKN HLDDETLAKL 430 440 450 460 470 IAKIPTITAV CNLHGEKLQV FKQSHPEIVN TLFPPLYKEL FNPDCATGCK
	Isoform 1 [UniParc]. Checksum: E15FD91422CCD67C	FASTA	459	52,073
	10 20 30 40 50 60 MRAQIEVIPC KICGDKSSGI HYGVITCEGC KGFFRRSQQN NASYSCPRQR NCLIDRTNRN 70 80 90 100 110 120 RCQHCRLQKC LALGMSRDAV KFGRMSKKQR DSLYAEVQKH QQRLQEQRQQ QSGEAEALAR 130 140 150 160 170 180 VYSSSISNGL SNLNNETSGT YANGHVIDLP KSEGYYNVDS GQPSPDQSGL DMTGIKQIKQ 190 200 210 220 230 240 EPIYDLTSVP NLFTYSSFNN GQLAPGITMT EIDRIAQNII KSHLETCQYT MEELHQLAWQ 250 260 270 280 290 300 THTYEEIKAY QSKSREALWQ QCAIQITHAI QYVVEFAKRI TGFMELCQND QILLLKSGCL 310 320 330 340 350 360 EVVLVRMCRA FNPLNNTVLF EGKYGGMQMF KALGSDDLVN EAFDFAKNLC SLQLTEEEIA 370 380 390 400 410 420 LFSSAVLISP DRAWLIEPRK VQKLQEKIYF ALQHVIQKNH LDDETLAKLI AKIPTITAVC 430 440 450 NLHGEKLQVF KQSHPEIVNT LFPPLYKELF NPDCATGCK

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	Becker-Andre M. Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1). Tissue: Retina.
[2]	"The full-ORF clone resource of the German cDNA consortium." Bechtel S., Rosenfelder H., Duda A., Schmidt C.P., Ernst U., Wellenreuther R., Mehrle A., Schuster C., Bahr A., Bloecker H., Heubner D., Hoerlein A., Michel G., Wedler H., Koehrer K., Ottenwaelder B., Poustka A., Wiemann S., Schupp I. BMC Genomics 8:399-399(2007) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2). Tissue: Retina.
[3]	"DNA sequence and analysis of human chromosome 9." Humphray S.J., Oliver K., Hunt A.R., Plumb R.W., Loveland J.E., Howe K.L., Andrews T.D., Searle S., Hunt S.E., Scott C.E., Jones M.C., Ainscough R., Almeida J.P., Ambrose K.D., Ashwell R.I.S., Babbage A.K., Babbage S., Bagguley C.L. , Bailey J., Banerjee R., Barker D.J., Barlow K.F., Bates K., Beasley H., Beasley O., Bird C.P., Bray-Allen S., Brown A.J., Brown J.Y., Burford D., Burrill W., Burton J., Carder C., Carter N.P., Chapman J.C., Chen Y., Clarke G., Clark S.Y., Clee C.M., Clegg S., Collier R.E., Corby N., Crosier M., Cummings A.T., Davies J., Dhami P., Dunn M., Dutta I., Dyer L.W., Earthrowl M.E., Faulkner L., Fleming C.J., Frankish A., Frankland J.A., French L., Fricker D.G., Garner P., Garnett J., Ghori J., Gilbert J.G.R., Glison C., Grafham D.V., Gribble S., Griffiths C., Griffiths-Jones S., Grocock R., Guy J., Hall R.E., Hammond S., Harley J.L., Harrison E.S.I., Hart E.A., Heath P.D., Henderson C.D., Hopkins B.L., Howard P.J., Howden P.J., Huckle E., Johnson C., Johnson D., Joy A.A., Kay M., Keenan S., Kershaw J.K., Kimberley A.M., King A., Knights A., Laird G.K., Langford C., Lawlor S., Leongamornlert D.A., Leversha M., Lloyd C., Lloyd D.M., Lovell J., Martin S., Mashreghi-Mohammadi M., Matthews L., McLaren S., McLay K.E., McMurray A., Milne S., Nickerson T., Nisbett J., Nordsiek G., Pearce A.V., Peck A.I., Porter K.M., Pandian R., Pelan S., Phillimore B., Povey S., Ramsey Y., Rand V., Scharfe M., Sehra H.K., Shownkeen R., Sims S.K., Skuce C.D., Smith M., Steward C.A., Swarbreck D., Sycamore N., Tester J., Thorpe A., Tracey A., Tromans A., Thomas D.W., Wall M., Wallis J.M., West A.P., Whitehead S.L., Willey D.L., Williams S.A., Wilming L., Wray P.W., Young L., Ashurst J.L., Coulson A., Blocker H., Durbin R.M., Sulston J.E., Hubbard T., Jackson M.J., Bentley D.R., Beck S., Rogers J., Dunham I. Nature 429:369-374(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08639 mRNA. Translation: CAA69929.1. BX647070 mRNA. No translation available. AL137018 Genomic DNA. Translation: CAD13276.2.
IPI	IPI00023259. IPI00827604.
RefSeq	NP_008845.2. NM_006914.3.
UniGene	Hs.494178.
3D structure databases
ProteinModelPortal	Q92753.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92753. 4 interactions.
STRING	9606.ENSP00000366093.
PTM databases
PhosphoSite	Q92753.
Polymorphism databases
DMDM	124028630.
Proteomic databases
PaxDb	Q92753.
PRIDE	Q92753.
Protocols and materials databases
DNASU	6096.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000376896; ENSP00000366093; ENSG00000198963. ENST00000396204; ENSP00000379507; ENSG00000198963.
GeneID	6096.
KEGG	hsa:6096.
UCSC	uc004aji.3. human.
Organism-specific databases
CTD	6096.
GeneCards	GC09P077112.
HGNC	HGNC:10259. RORB.
HPA	HPA008393.
MIM	601972. gene.
neXtProt	NX_Q92753.
PharmGKB	PA34631.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG324222.
HOGENOM	HOG000010200.
HOVERGEN	HBG106848.
InParanoid	Q92753.
KO	K08533.
OMA	SGHTMRA.
OrthoDB	EOG4KH2TT.
Enzyme and pathway databases
Reactome	REACT_71. Gene Expression.
Gene expression databases
ArrayExpress	Q92753.
Bgee	Q92753.
CleanEx	HS_RORB.
Genevestigator	Q92753.
GermOnline	ENSG00000198963. Homo sapiens.
Family and domain databases
Gene3D	1.10.565.10. 2 hits. 3.30.50.10. 1 hit.
InterPro	IPR008946. Nucl_hormone_rcpt_ligand-bd. IPR000536. Nucl_hrmn_rcpt_lig-bd_core. IPR003079. ROR_rcpt. IPR001723. Str_hrmn_rcpt. IPR001628. Znf_hrmn_rcpt. IPR013088. Znf_NHR/GATA. [Graphical view]
Pfam	PF00104. Hormone_recep. 1 hit. PF00105. zf-C4. 1 hit. [Graphical view]
PRINTS	PR01293. RORNUCRECPTR. PR00398. STRDHORMONER. PR00047. STROIDFINGER.
SMART	SM00430. HOLI. 1 hit. SM00399. ZnF_C4. 1 hit. [Graphical view]
SUPFAM	SSF48508. Str_ncl_receptor. 1 hit.
PROSITE	PS00031. NUCLEAR_REC_DBD_1. 1 hit. PS51030. NUCLEAR_REC_DBD_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
ChiTaRS	RORB. human.
GenomeRNAi	6096.
NextBio	23713.
SOURCE	Search...

Entry information

Entry name

RORB_HUMAN

Accession

Primary (citable) accession number: Q92753
Secondary accession number(s): Q8WX73

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	January 23, 2007
Last modified:	May 1, 2013
This is version 118 of the entry and version 3 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.