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Protein

Tenascin-R

Gene

TNR

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Neural extracellular matrix (ECM) protein involved in interactions with different cells and matrix components. These interactions can influence cellular behavior by either evoking a stable adhesion and differentiation, or repulsion and inhibition of neurite growth. Binding to cell surface gangliosides inhibits RGD-dependent integrin-mediated cell adhesion and results in an inhibition of PTK2/FAK1 (FAK) phosphorylation and cell detachment. Binding to membrane surface sulfatides results in a oligodendrocyte adhesion and differentiation. Interaction with CNTN1 induces a repulsion of neurons and an inhibition of neurite outgrowth. Interacts with SCN2B may play a crucial role in clustering and regulation of activity of sodium channels at nodes of Ranvier. TNR-linked chondroitin sulfate glycosaminoglycans are involved in the interaction with FN1 and mediate inhibition of cell adhesion and neurite outgrowth. The highly regulated addition of sulfated carbohydrate structure may modulate the adhesive properties of TNR over the course of development and during synapse maintenance (By similarity).By similarity

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Cell adhesion

Keywords - Ligandi

Sialic acid

Enzyme and pathway databases

ReactomeiR-HSA-3000178. ECM proteoglycans.

Names & Taxonomyi

Protein namesi
Recommended name:
Tenascin-R
Short name:
TN-R
Alternative name(s):
Janusin
Restrictin
Gene namesi
Name:TNR
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

HGNCiHGNC:11953. TNR.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Extracellular matrix, Secreted

Pathology & Biotechi

Organism-specific databases

DisGeNETi7143.
OpenTargetsiENSG00000116147.
PharmGKBiPA36642.

Polymorphism and mutation databases

BioMutaiTNR.
DMDMi311033534.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 31Sequence analysisAdd BLAST31
ChainiPRO_000000774732 – 1358Tenascin-RAdd BLAST1327

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi36O-linked (GalNAc...)1 Publication1
Glycosylationi37O-linked (GalNAc...)1 Publication1
Glycosylationi55N-linked (GlcNAc...)Sequence analysis1
Glycosylationi180N-linked (GlcNAc...)Sequence analysis1
Glycosylationi198N-linked (GlcNAc...)Sequence analysis1
Glycosylationi278N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi292 ↔ 301PROSITE-ProRule annotation
Disulfide bondi297 ↔ 312PROSITE-ProRule annotation
Disulfide bondi314 ↔ 323PROSITE-ProRule annotation
Glycosylationi392N-linked (GlcNAc...)Sequence analysis1
Glycosylationi470N-linked (GlcNAc...)Sequence analysis1
Glycosylationi581N-linked (GlcNAc...)Sequence analysis1
Modified residuei724PhosphoserineBy similarity1
Glycosylationi791N-linked (GlcNAc...)Sequence analysis1
Glycosylationi874N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1036N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1046N-linked (GlcNAc...)Sequence analysis1
Glycosylationi1261N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Contains N-linked oligosaccharides, O-linked sialylated structures and O-linked chondroitin sulfate glycosaminoglycans. Contains N-linked oligosaccharides with a sulfated carbohydrate structure (By similarity). O-glycosylated on Thr-36 or Thr-37 with a core 1 or possibly core 8 glycan.By similarity1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein, Proteoglycan

Proteomic databases

PaxDbiQ92752.
PeptideAtlasiQ92752.
PRIDEiQ92752.

PTM databases

iPTMnetiQ92752.
PhosphoSitePlusiQ92752.
SwissPalmiQ92752.

Expressioni

Tissue specificityi

Brain specific.1 Publication

Gene expression databases

BgeeiENSG00000116147.
CleanExiHS_TNR.
ExpressionAtlasiQ92752. baseline and differential.
GenevisibleiQ92752. HS.

Organism-specific databases

HPAiCAB022343.
HPA027134.
HPA027150.
HPA029859.

Interactioni

Subunit structurei

Forms oligomers. Interacts with CNTN1, TNC, and FN1. Interacts with BCAN and ACAN in a calcium-dependent manner. Interacts with SCN2B, PTPRZ1, and CSPG3 (By similarity).By similarity

Protein-protein interaction databases

BioGridi112997. 10 interactors.
IntActiQ92752. 1 interactor.
STRINGi9606.ENSP00000263525.

Structurei

3D structure databases

ProteinModelPortaliQ92752.
SMRiQ92752.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini188 – 199EGF-like 1Add BLAST12
Domaini219 – 230EGF-like 2Add BLAST12
Domaini250 – 261EGF-like 3Add BLAST12
Domaini281 – 292EGF-like 4Add BLAST12
Domaini312 – 323EGF-like 5Add BLAST12
Domaini328 – 420Fibronectin type-III 1PROSITE-ProRule annotationAdd BLAST93
Domaini421 – 505Fibronectin type-III 2PROSITE-ProRule annotationAdd BLAST85
Domaini506 – 595Fibronectin type-III 3PROSITE-ProRule annotationAdd BLAST90
Domaini596 – 687Fibronectin type-III 4PROSITE-ProRule annotationAdd BLAST92
Domaini688 – 777Fibronectin type-III 5PROSITE-ProRule annotationAdd BLAST90
Domaini778 – 865Fibronectin type-III 6PROSITE-ProRule annotationAdd BLAST88
Domaini866 – 955Fibronectin type-III 7PROSITE-ProRule annotationAdd BLAST90
Domaini956 – 1042Fibronectin type-III 8PROSITE-ProRule annotationAdd BLAST87
Domaini1043 – 1130Fibronectin type-III 9PROSITE-ProRule annotationAdd BLAST88
Domaini1129 – 1344Fibrinogen C-terminalPROSITE-ProRule annotationAdd BLAST216

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili127 – 157Sequence analysisAdd BLAST31

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi155 – 314Cys-richAdd BLAST160

Domaini

The EGF-like domains mediate interaction with CNTN1. The fibronectin type-III domains 3-5 mediate interaction with BCAN. The fibronectin type-III domains 1-2 and 7-9 mediate interaction with SCN2B (By similarity).By similarity

Sequence similaritiesi

Belongs to the tenascin family.Curated
Contains 5 EGF-like domains.Curated
Contains 1 fibrinogen C-terminal domain.PROSITE-ProRule annotation
Contains 9 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, EGF-like domain, Repeat, Signal

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
InParanoidiQ92752.
KOiK06252.
OMAiKACPCAS.
OrthoDBiEOG091G03M1.
PhylomeDBiQ92752.
TreeFamiTF329915.

Family and domain databases

CDDicd00063. FN3. 9 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 9 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033079. TNR.
[Graphical view]
PANTHERiPTHR19143:SF254. PTHR19143:SF254. 2 hits.
PfamiPF07974. EGF_2. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 9 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92752-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGADGETVVL KNMLIGINLI LLGSMIKPSE CQLEVTTERV QRQSVEEEGG
60 70 80 90 100
IANYNTSSKE QPVVFNHVYN INVPLDNLCS SGLEASAEQE VSAEDETLAE
110 120 130 140 150
YMGQTSDHES QVTFTHRINF PKKACPCASS AQVLQELLSR IEMLEREVSV
160 170 180 190 200
LRDQCNANCC QESAATGQLD YIPHCSGHGN FSFESCGCIC NEGWFGKNCS
210 220 230 240 250
EPYCPLGCSS RGVCVDGQCI CDSEYSGDDC SELRCPTDCS SRGLCVDGEC
260 270 280 290 300
VCEEPYTGED CRELRCPGDC SGKGRCANGT CLCEEGYVGE DCGQRQCLNA
310 320 330 340 350
CSGRGQCEEG LCVCEEGYQG PDCSAVAPPE DLRVAGISDR SIELEWDGPM
360 370 380 390 400
AVTEYVISYQ PTALGGLQLQ QRVPGDWSGV TITELEPGLT YNISVYAVIS
410 420 430 440 450
NILSLPITAK VATHLSTPQG LQFKTITETT VEVQWEPFSF SFDGWEISFI
460 470 480 490 500
PKNNEGGVIA QVPSDVTSFN QTGLKPGEEY IVNVVALKEQ ARSPPTSASV
510 520 530 540 550
STVIDGPTQI LVRDVSDTVA FVEWIPPRAK VDFILLKYGL VGGEGGRTTF
560 570 580 590 600
RLQPPLSQYS VQALRPGSRY EVSVSAVRGT NESDSATTQF TTEIDAPKNL
610 620 630 640 650
RVGSRTATSL DLEWDNSEAE VQEYKVVYST LAGEQYHEVL VPRGIGPTTR
660 670 680 690 700
ATLTDLVPGT EYGVGISAVM NSQQSVPATM NARTELDSPR DLMVTASSET
710 720 730 740 750
SISLIWTKAS GPIDHYRITF TPSSGIASEV TVPKDRTSYT LTDLEPGAEY
760 770 780 790 800
IISVTAERGR QQSLESTVDA FTGFRPISHL HFSHVTSSSV NITWSDPSPP
810 820 830 840 850
ADRLILNYSP RDEEEEMMEV SLDATKRHAV LMGLQPATEY IVNLVAVHGT
860 870 880 890 900
VTSEPIVGSI TTGIDPPKDI TISNVTKDSV MVSWSPPVAS FDYYRVSYRP
910 920 930 940 950
TQVGRLDSSV VPNTVTEFTI TRLNPATEYE ISLNSVRGRE ESERICTLVH
960 970 980 990 1000
TAMDNPVDLI ATNITPTEAL LQWKAPVGEV ENYVIVLTHF AVAGETILVD
1010 1020 1030 1040 1050
GVSEEFRLVD LLPSTHYTAT MYATNGPLTS GTISTNFSTL LDPPANLTAS
1060 1070 1080 1090 1100
EVTRQSALIS WQPPRAEIEN YVLTYKSTDG SRKELIVDAE DTWIRLEGLL
1110 1120 1130 1140 1150
ENTDYTVLLQ AAQDTTWSSI TSTAFTTGGR VFPHPQDCAQ HLMNGDTLSG
1160 1170 1180 1190 1200
VYPIFLNGEL SQKLQVYCDM TTDGGGWIVF QRRQNGQTDF FRKWADYRVG
1210 1220 1230 1240 1250
FGNVEDEFWL GLDNIHRITS QGRYELRVDM RDGQEAAFAS YDRFSVEDSR
1260 1270 1280 1290 1300
NLYKLRIGSY NGTAGDSLSY HQGRPFSTED RDNDVAVTNC AMSYKGAWWY
1310 1320 1330 1340 1350
KNCHRTNLNG KYGESRHSQG INWYHWKGHE FSIPFVEMKM RPYNHRLMAG

RKRQSLQF
Length:1,358
Mass (Da):149,562
Last modified:November 2, 2010 - v3
Checksum:iE4DE356B44D117E7
GO
Isoform 2 (identifier: Q92752-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     773-862: Missing.

Show »
Length:1,268
Mass (Da):139,695
Checksum:iE4EB4095284A4E29
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti629S → I in CAA66709 (Ref. 2) Curated1

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02147917I → V.2 PublicationsCorresponds to variant rs859398dbSNPEnsembl.1
Natural variantiVAR_021906128A → S.Corresponds to variant rs2239819dbSNPEnsembl.1
Natural variantiVAR_021907293G → S.Corresponds to variant rs3752516dbSNPEnsembl.1
Natural variantiVAR_055780302S → N.Corresponds to variant rs35736986dbSNPEnsembl.1
Natural variantiVAR_030737643R → K.Corresponds to variant rs859427dbSNPEnsembl.1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_012993773 – 862Missing in isoform 2. 1 PublicationAdd BLAST90

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67996 mRNA. Translation: CAA91947.1.
X98085 mRNA. Translation: CAA66709.1.
AL021919 Genomic DNA. No translation available.
AL023285 Genomic DNA. No translation available.
AL136530 Genomic DNA. No translation available.
Z94057, Z94055 Genomic DNA. Translation: CAI21650.1.
Z94055, Z94057 Genomic DNA. Translation: CAI19943.1.
CCDSiCCDS1318.1. [Q92752-1]
RefSeqiNP_003276.3. NM_003285.2. [Q92752-1]
XP_016857707.1. XM_017002218.1. [Q92752-1]
XP_016857708.1. XM_017002219.1. [Q92752-1]
UniGeneiHs.659864.

Genome annotation databases

EnsembliENST00000263525; ENSP00000263525; ENSG00000116147. [Q92752-1]
ENST00000367674; ENSP00000356646; ENSG00000116147. [Q92752-1]
GeneIDi7143.
KEGGihsa:7143.
UCSCiuc009wwu.2. human. [Q92752-1]

Keywords - Coding sequence diversityi

Alternative splicing, Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Z67996 mRNA. Translation: CAA91947.1.
X98085 mRNA. Translation: CAA66709.1.
AL021919 Genomic DNA. No translation available.
AL023285 Genomic DNA. No translation available.
AL136530 Genomic DNA. No translation available.
Z94057, Z94055 Genomic DNA. Translation: CAI21650.1.
Z94055, Z94057 Genomic DNA. Translation: CAI19943.1.
CCDSiCCDS1318.1. [Q92752-1]
RefSeqiNP_003276.3. NM_003285.2. [Q92752-1]
XP_016857707.1. XM_017002218.1. [Q92752-1]
XP_016857708.1. XM_017002219.1. [Q92752-1]
UniGeneiHs.659864.

3D structure databases

ProteinModelPortaliQ92752.
SMRiQ92752.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi112997. 10 interactors.
IntActiQ92752. 1 interactor.
STRINGi9606.ENSP00000263525.

PTM databases

iPTMnetiQ92752.
PhosphoSitePlusiQ92752.
SwissPalmiQ92752.

Polymorphism and mutation databases

BioMutaiTNR.
DMDMi311033534.

Proteomic databases

PaxDbiQ92752.
PeptideAtlasiQ92752.
PRIDEiQ92752.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000263525; ENSP00000263525; ENSG00000116147. [Q92752-1]
ENST00000367674; ENSP00000356646; ENSG00000116147. [Q92752-1]
GeneIDi7143.
KEGGihsa:7143.
UCSCiuc009wwu.2. human. [Q92752-1]

Organism-specific databases

CTDi7143.
DisGeNETi7143.
GeneCardsiTNR.
H-InvDBHIX0028854.
HGNCiHGNC:11953. TNR.
HPAiCAB022343.
HPA027134.
HPA027150.
HPA029859.
MIMi601995. gene.
neXtProtiNX_Q92752.
OpenTargetsiENSG00000116147.
PharmGKBiPA36642.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1225. Eukaryota.
KOG2579. Eukaryota.
ENOG410ZYS4. LUCA.
GeneTreeiENSGT00830000128240.
HOGENOMiHOG000234355.
HOVERGENiHBG008949.
InParanoidiQ92752.
KOiK06252.
OMAiKACPCAS.
OrthoDBiEOG091G03M1.
PhylomeDBiQ92752.
TreeFamiTF329915.

Enzyme and pathway databases

ReactomeiR-HSA-3000178. ECM proteoglycans.

Miscellaneous databases

GeneWikiiTenascin-R.
GenomeRNAii7143.
PROiQ92752.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000116147.
CleanExiHS_TNR.
ExpressionAtlasiQ92752. baseline and differential.
GenevisibleiQ92752. HS.

Family and domain databases

CDDicd00063. FN3. 9 hits.
cd00087. FReD. 1 hit.
Gene3Di2.60.40.10. 9 hits.
3.90.215.10. 1 hit.
4.10.530.10. 1 hit.
InterProiIPR013032. EGF-like_CS.
IPR000742. EGF-like_dom.
IPR013111. EGF_extracell.
IPR014716. Fibrinogen_a/b/g_C_1.
IPR014715. Fibrinogen_a/b/g_C_2.
IPR002181. Fibrinogen_a/b/g_C_dom.
IPR003961. FN3_dom.
IPR013783. Ig-like_fold.
IPR033079. TNR.
[Graphical view]
PANTHERiPTHR19143:SF254. PTHR19143:SF254. 2 hits.
PfamiPF07974. EGF_2. 1 hit.
PF00147. Fibrinogen_C. 1 hit.
PF00041. fn3. 9 hits.
[Graphical view]
SMARTiSM00181. EGF. 4 hits.
SM00186. FBG. 1 hit.
SM00060. FN3. 9 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 5 hits.
SSF56496. SSF56496. 1 hit.
PROSITEiPS00022. EGF_1. 5 hits.
PS01186. EGF_2. 4 hits.
PS51406. FIBRINOGEN_C_2. 1 hit.
PS50853. FN3. 9 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiTENR_HUMAN
AccessioniPrimary (citable) accession number: Q92752
Secondary accession number(s): C9J563, Q15568, Q5R3G0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2005
Last sequence update: November 2, 2010
Last modified: November 30, 2016
This is version 147 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.