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Protein

Thyroid hormone-inducible hepatic protein

Gene

THRSP

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the regulation of lipogenesis, especially in lactating mammary gland. Important for the biosynthesis of triglycerides with medium-length fatty acid chains. May modulate lipogenesis by interacting with MID1IP1 and preventing its interaction with ACACA (By similarity). May function as transcriptional coactivator. May modulate the transcription factor activity of THRB.By similarity2 Publications

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: Ensembl

GO - Biological processi

Keywordsi

Biological processLipid biosynthesis, Lipid metabolism, Transcription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-HSA-200425. Import of palmitoyl-CoA into the mitochondrial matrix.

Names & Taxonomyi

Protein namesi
Recommended name:
Thyroid hormone-inducible hepatic protein
Alternative name(s):
Spot 14 protein
Short name:
S14
Short name:
SPOT14
Gene namesi
Name:THRSP
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 11

Organism-specific databases

HGNCiHGNC:11800. THRSP.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi7069.
OpenTargetsiENSG00000151365.
PharmGKBiPA36509.

Polymorphism and mutation databases

BioMutaiTHRSP.
DMDMi2842710.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001237731 – 146Thyroid hormone-inducible hepatic proteinAdd BLAST146

Proteomic databases

PaxDbiQ92748.
PeptideAtlasiQ92748.
PRIDEiQ92748.

PTM databases

PhosphoSitePlusiQ92748.

Expressioni

Tissue specificityi

Mainly expressed in tissues that synthesize triglycerides.

Gene expression databases

BgeeiENSG00000151365.
CleanExiHS_THRSP.
GenevisibleiQ92748. HS.

Organism-specific databases

HPAiHPA040642.

Interactioni

Subunit structurei

Homodimer. Heterodimer with MID1IP1 (By similarity). Interacts with THRB and PLAGL1.By similarity2 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself3EBI-1749955,EBI-1749955

GO - Molecular functioni

  • identical protein binding Source: IntAct
  • protein homodimerization activity Source: Ensembl

Protein-protein interaction databases

BioGridi112925. 61 interactors.
DIPiDIP-40451N.
IntActiQ92748. 25 interactors.
STRINGi9606.ENSP00000281030.

Structurei

3D structure databases

ProteinModelPortaliQ92748.
SMRiQ92748.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the SPOT14 family.Curated

Phylogenomic databases

eggNOGiENOG410J34G. Eukaryota.
ENOG410YT7Q. LUCA.
GeneTreeiENSGT00500000044890.
HOGENOMiHOG000001157.
HOVERGENiHBG002528.
InParanoidiQ92748.
OMAiTVMDRYS.
OrthoDBiEOG091G0Z4G.
PhylomeDBiQ92748.
TreeFamiTF326826.

Family and domain databases

InterProiView protein in InterPro
IPR009786. Spot_14.
PANTHERiPTHR14315. PTHR14315. 1 hit.
PfamiView protein in Pfam
PF07084. Spot_14. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92748-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MQVLTKRYPK NCLLTVMDRY AAEVHNMEQV VMIPSLLRDV QLSGPGGQAQ
60 70 80 90 100
AEAPDLYTYF TMLKAICVDV DHGLLPREEW QAKVAGSEEN GTAETEEVED
110 120 130 140
ESASGELDLE AQFHLHFSSL HHILMHLTEK AQEVTRKYQE MTGQVW
Length:146
Mass (Da):16,561
Last modified:February 1, 1997 - v1
Checksum:i5135FB8EE380DF8F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08409 Genomic DNA. Translation: CAA69685.1.
AK311975 mRNA. Translation: BAG34914.1.
CH471076 Genomic DNA. Translation: EAW75045.1.
BC031989 mRNA. Translation: AAH31989.1.
CCDSiCCDS8256.1.
RefSeqiNP_003242.1. NM_003251.3.
UniGeneiHs.591969.

Genome annotation databases

EnsembliENST00000281030; ENSP00000281030; ENSG00000151365.
GeneIDi7069.
KEGGihsa:7069.
UCSCiuc001oyx.4. human.

Similar proteinsi

Entry informationi

Entry nameiTHRSP_HUMAN
AccessioniPrimary (citable) accession number: Q92748
Secondary accession number(s): B2R4W7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: August 30, 2017
This is version 122 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 11
    Human chromosome 11: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families