Q92747 (ARC1A_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Actin-related protein 2/3 complex subunit 1A

Alternative name(s):
SOP2-like protein

Gene names

Name:	ARPC1A
Synonyms:	SOP2L

Organism

Homo sapiens (Human)

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subunit structure	Probable component of the Arp2/3 complex in which it may replace ARPC1B.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Sequence similarities	Belongs to the WD repeat ARPC1 family. Contains 6 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Repeat WD repeat
Ligand	Actin-binding
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Traceable author statement. Source: ProtInc regulation of actin filament polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Traceable author statement. Source: ProtInc cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Traceable author statement. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Actin-related protein 2/3 complex subunit 1A		PRO_0000050852
Regions
	Repeat	6 – 45	40	WD 1
	Repeat	50 – 89	40	WD 2
	Repeat	140 – 179	40	WD 3
	Repeat	202 – 241	40	WD 4
	Repeat	244 – 284	41	WD 5
	Repeat	322 – 365	44	WD 6
Experimental info
	Sequence conflict	127	1	S → A in CAA70203. Ref.1
	Sequence conflict	180	1	P → K in CAA70203. Ref.1
	Sequence conflict	273	1	N → I in CAA70203. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92747 [UniParc]. Last modified February 21, 2006. Version 2. Checksum: 57FA5AC69997636E	FASTA	370	41,569
	10 20 30 40 50 60 MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW 70 80 90 100 110 120 APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI 130 140 150 160 170 180 SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP 190 200 210 220 230 240 ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS 250 260 270 280 290 300 TLKTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM 310 320 330 340 350 360 ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL 370 ESSIQGLRIM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function." Balasubramanian M.K., Feoktostiva A., McCollum D., Gould K.L. EMBO J. 15:6426-6437(1996) [PubMed: 8978670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"Human chromosome 7: DNA sequence and biology." Scherer S.W., Cheung J., MacDonald J.R., Osborne L.R., Nakabayashi K., Herbrick J.-A., Carson A.R., Parker-Katiraee L., Skaug J., Khaja R., Zhang J., Hudek A.K., Li M., Haddad M., Duggan G.E., Fernandez B.A., Kanematsu E., Gentles S. , Christopoulos C.C., Choufani S., Kwasnicka D., Zheng X.H., Lai Z., Nusskern D.R., Zhang Q., Gu Z., Lu F., Zeesman S., Nowaczyk M.J., Teshima I., Chitayat D., Shuman C., Weksberg R., Zackai E.H., Grebe T.A., Cox S.R., Kirkpatrick S.J., Rahman N., Friedman J.M., Heng H.H.Q., Pelicci P.G., Lo-Coco F., Belloni E., Shaffer L.G., Pober B., Morton C.C., Gusella J.F., Bruns G.A.P., Korf B.R., Quade B.J., Ligon A.H., Ferguson H., Higgins A.W., Leach N.T., Herrick S.R., Lemyre E., Farra C.G., Kim H.-G., Summers A.M., Gripp K.W., Roberts W., Szatmari P., Winsor E.J.T., Grzeschik K.-H., Teebi A., Minassian B.A., Kere J., Armengol L., Pujana M.A., Estivill X., Wilson M.D., Koop B.F., Tosi S., Moore G.E., Boright A.P., Zlotorynski E., Kerem B., Kroisel P.M., Petek E., Oscier D.G., Mould S.J., Doehner H., Doehner K., Rommens J.M., Vincent J.B., Venter J.C., Li P.W., Mural R.J., Adams M.D., Tsui L.-C. Science 300:767-772(2003) [PubMed: 12690205] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[3]	Mural R.J., Istrail S., Sutton G.G., Florea L., Halpern A.L., Mobarry C.M., Lippert R., Walenz B., Shatkay H., Dew I., Miller J.R., Flanigan M.J., Edwards N.J., Bolanos R., Fasulo D., Halldorsson B.V., Hannenhalli S., Turner R. , Yooseph S., Lu F., Nusskern D.R., Shue B.C., Zheng X.H., Zhong F., Delcher A.L., Huson D.H., Kravitz S.A., Mouchard L., Reinert K., Remington K.A., Clark A.G., Waterman M.S., Eichler E.E., Adams M.D., Hunkapiller M.W., Myers E.W., Venter J.C. Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Uterus.
[5]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed: 21269460] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y08999 mRNA. Translation: CAA70203.1. CH236956 Genomic DNA. Translation: EAL23883.1. CH471091 Genomic DNA. Translation: EAW76682.1. CH471091 Genomic DNA. Translation: EAW76683.1. BC039594 mRNA. Translation: AAH39594.2. BC047889 mRNA. Translation: AAH47889.2. BC054027 mRNA. Translation: AAH54027.1.
IPI	IPI00333068.
RefSeq	NP_006400.2. NM_006409.3.
UniGene	Hs.124126.
3D structure databases
ProteinModelPortal	Q92747.
SMR	Q92747. Positions 2-370.
ModBase	Search...
Protein-protein interaction databases
DIP	DIP-33142N.
IntAct	Q92747. 1 interaction.
STRING	Q92747.
PTM databases
PhosphoSite	Q92747.
Polymorphism databases
DMDM	88984001.
Proteomic databases
PeptideAtlas	Q92747.
PRIDE	Q92747.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000262942; ENSP00000262942; ENSG00000241685.
GeneID	10552.
KEGG	hsa:10552.
UCSC	uc003upx.1. human.
Organism-specific databases
CTD	10552.
GeneCards	GC07P098923.
HGNC	HGNC:703. ARPC1A.
HPA	HPA004334.
MIM	604220. gene.
neXtProt	NX_Q92747.
PharmGKB	PA24997.
GenAtlas	Search...
Phylogenomic databases
GeneTree	ENSGT00390000008339.
HOVERGEN	HBG050560.
InParanoid	Q92747.
OMA	IHQNAIT.
OrthoDB	EOG4NZTTG.
PhylomeDB	Q92747.
Gene expression databases
ArrayExpress	Q92747.
Bgee	Q92747.
CleanEx	HS_ARPC1A.
Genevestigator	Q92747.
GermOnline	ENSG00000013455. Homo sapiens.
Family and domain databases
InterPro	IPR017383. ARPC2/3_su1. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR017986. WD40_repeat_dom. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
KO	K05757.
PANTHER	PTHR10709. PTHR10709. 1 hit.
Pfam	PF00400. WD40. 3 hits. [Graphical view]
PIRSF	PIRSF038093. ARP2/3_su1. 1 hit.
SMART	SM00320. WD40. 6 hits. [Graphical view]
SUPFAM	SSF50978. WD40_like. 1 hit.
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	40025.
SOURCE	Search...

Entry information

Entry name

ARC1A_HUMAN

Accession

Primary (citable) accession number: Q92747
Secondary accession number(s): A4D276 , D6W5S1, Q7Z5U8, Q86WU5, Q8IXQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 21, 2006
Last modified:	January 25, 2012
This is version 99 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.