Reviewed, UniProtKB/Swiss-Prot Q92747 (ARC1A_HUMAN)

Names and origin

Protein names

Recommended name:
    Actin-related protein 2/3 complex subunit 1A
Alternative name(s):
    SOP2-like protein

Gene names

Name:	ARPC1A
Synonyms:	SOP2L

Organism

Homo sapiens (Human) [Complete proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Primates › Haplorrhini › Catarrhini › Hominidae › Homo

Protein attributes

Sequence length	370 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Evidence at protein level.

General annotation (Comments)

Function	Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.
Subunit structure	Probable component of the Arp2/3 complex in which it may replace ARPC1B.
Subcellular location	Cytoplasm › cytoskeleton Probable.
Sequence similarities	Belongs to the WD repeat ARPC1 family. Contains 6 WD repeats.

Ontologies

Keywords
Cellular component	Cytoplasm Cytoskeleton
Domain	Repeat WD repeat
Ligand	Actin-binding
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	actin cytoskeleton organization Ref.1 Traceable author statement. Source: ProtInc regulation of actin filament polymerization Inferred from electronic annotation. Source: InterPro
Cellular component	actin cytoskeleton Ref.1 Traceable author statement. Source: ProtInc cytoplasm Inferred from electronic annotation. Source: UniProtKB-KW
Molecular function	actin binding Ref.1 Traceable author statement. Source: ProtInc
Complete GO annotation...

Binary interactions

With	Entry	#Exp.	IntAct	Notes
ACTR3B	Q9P1U1	1	EBI-1020827,EBI-1047175

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 370	370	Actin-related protein 2/3 complex subunit 1A		PRO_0000050852
Regions
	Repeat	6 – 45	40	WD 1
	Repeat	50 – 89	40	WD 2
	Repeat	140 – 179	40	WD 3
	Repeat	202 – 241	40	WD 4
	Repeat	244 – 284	41	WD 5
	Repeat	322 – 365	44	WD 6
Experimental info
	Sequence conflict	127	1	S → A in CAA70203. Ref.1
	Sequence conflict	180	1	P → K in CAA70203. Ref.1
	Sequence conflict	273	1	N → I in CAA70203. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q92747-1 [UniParc]. Last modified February 21, 2006. Version 2. Checksum: 57FA5AC69997636E	FASTA	370	41,569
	10 20 30 40 50 60 MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE HNGHITGIDW 70 80 90 100 110 120 APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT FVKWSPLENK FAVGSGARLI 130 140 150 160 170 180 SVCYFESEND WWVSKHIKKP IRSTVLSLDW HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP 190 200 210 220 230 240 ASTPWGSKMP FGQLMSEFGG SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS 250 260 270 280 290 300 TLKTEFLPLL SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM 310 320 330 340 350 360 ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG AMTIWDFKTL 370 ESSIQGLRIM

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Fission yeast Sop2p: a novel and evolutionarily conserved protein that interacts with Arp3p and modulates profilin function." Balasubramanian M.K., Feoktostiva A., McCollum D., Gould K.L. EMBO J. 15:6426-6437(1996) [PubMed: 8978670] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Pancreas and Uterus.
[3]	Colinge J., Superti-Furga G., Bennett K.L. Submitted (OCT-2008) to UniProtKB Cited for: IDENTIFICATION [LARGE SCALE ANALYSIS], MASS SPECTROMETRY.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	Y08999 mRNA. Translation: CAA70203.1. BC039594 mRNA. Translation: AAH39594.2. BC047889 mRNA. Translation: AAH47889.2. BC054027 mRNA. Translation: AAH54027.1.
IPI	IPI00333068.
RefSeq	NP_006400.2.
UniGene	Hs.124126
3D structure databases
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92747. 3 interactions.
STRING	Q92747.
Proteomic databases
PeptideAtlas	Q92747.
PRIDE	Q92747.
Genome annotation databases
Ensembl	ENST00000262942; ENSP00000262942; ENSG00000241685; Homo sapiens. [Genome view]
GeneID	10552.
KEGG	hsa:10552.
UCSC	uc003upx.1. human.
Organism-specific databases
CTD	10552.
GeneCards	GC07P098761.
H-InvDB	HIX0025315.
HGNC	HGNC:703. ARPC1A.
HPA	HPA004334.
MIM	604220. gene.
PharmGKB	PA24997.
GenAtlas	Search...
Phylogenomic databases
HOVERGEN	Q92747.
OMA	NAYVWTQ
OrthoDB	EOG9W3W75
Gene expression databases
ArrayExpress	Q92747.
Bgee	Q92747.
CleanEx	HS_ARPC1A.
Genevestigator	Q92747.
GermOnline	ENSG00000013455. Homo sapiens.
Family and domain databases
InterPro	IPR017383. ARPC2/3_su1. IPR015943. WD40/YVTN_repeat-like_dom. IPR001680. WD40_repeat. IPR011046. WD40_repeat-like_dom. IPR019782. WD40_repeat_2. IPR017986. WD40_repeat_dom. IPR019781. WD40_repeat_sg. [Graphical view]
Gene3D	G3DSA:2.130.10.10. WD40/YVTN_repeat-like. 1 hit.
Pfam	PF00400. WD40. 2 hits. [Graphical view]
PIRSF	PIRSF038093. ARP2/3_su1. 1 hit.
SMART	SM00320. WD40. 6 hits. [Graphical view]
PROSITE	PS00678. WD_REPEATS_1. False negative. PS50082. WD_REPEATS_2. 1 hit. PS50294. WD_REPEATS_REGION. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	40025.
SOURCE	Search...

Entry information

Entry name

ARC1A_HUMAN

Accession

Primary (citable) accession number: Q92747
Secondary accession number(s): Q7Z5U8, Q86WU5, Q8IXQ0

Entry history

Integrated into UniProtKB/Swiss-Prot:	July 15, 1998
Last sequence update:	February 21, 2006
Last modified:	November 24, 2009
This is version 78 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.