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Protein

Actin-related protein 2/3 complex subunit 1A

Gene

ARPC1A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probably functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.

GO - Molecular functioni

  • actin binding Source: ProtInc
  • actin filament binding Source: GO_Central

GO - Biological processi

Complete GO annotation...

Keywords - Ligandi

Actin-binding

Enzyme and pathway databases

ReactomeiR-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiQ92747.

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-related protein 2/3 complex subunit 1A
Alternative name(s):
SOP2-like protein
Gene namesi
Name:ARPC1A
Synonyms:SOP2L
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 7

Organism-specific databases

HGNCiHGNC:703. ARPC1A.

Subcellular locationi

GO - Cellular componenti

  • actin cytoskeleton Source: ProtInc
  • Arp2/3 protein complex Source: GO_Central
  • cytosol Source: Reactome
  • extracellular exosome Source: UniProtKB
  • muscle cell projection membrane Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

Pathology & Biotechi

Organism-specific databases

PharmGKBiPA24997.

Polymorphism and mutation databases

BioMutaiARPC1A.
DMDMi88984001.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 370370Actin-related protein 2/3 complex subunit 1APRO_0000050852Add
BLAST

Proteomic databases

EPDiQ92747.
PaxDbiQ92747.
PeptideAtlasiQ92747.
PRIDEiQ92747.

PTM databases

iPTMnetiQ92747.
PhosphoSiteiQ92747.
SwissPalmiQ92747.

Expressioni

Gene expression databases

BgeeiENSG00000241685.
CleanExiHS_ARPC1A.
ExpressionAtlasiQ92747. baseline and differential.
GenevisibleiQ92747. HS.

Organism-specific databases

HPAiHPA004334.

Interactioni

Subunit structurei

Probable component of the Arp2/3 complex in which it may replace ARPC1B.

GO - Molecular functioni

  • actin binding Source: ProtInc
  • actin filament binding Source: GO_Central

Protein-protein interaction databases

BioGridi115803. 34 interactions.
DIPiDIP-33142N.
IntActiQ92747. 6 interactions.
MINTiMINT-3049287.
STRINGi9606.ENSP00000262942.

Structurei

3D structure databases

ProteinModelPortaliQ92747.
SMRiQ92747. Positions 2-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Repeati6 – 4540WD 1Add
BLAST
Repeati50 – 8940WD 2Add
BLAST
Repeati140 – 17940WD 3Add
BLAST
Repeati202 – 24140WD 4Add
BLAST
Repeati244 – 28441WD 5Add
BLAST
Repeati322 – 36544WD 6Add
BLAST

Sequence similaritiesi

Belongs to the WD repeat ARPC1 family.Curated
Contains 6 WD repeats.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, WD repeat

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ92747.
KOiK05757.
OMAiISAMRIF.
OrthoDBiEOG091G096H.
PhylomeDBiQ92747.
TreeFamiTF315041.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030140. ARC1A.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF11. PTHR10709:SF11. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92747-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSLHQFLLEP ITCHAWNRDR TQIALSPNNH EVHIYKKNGS QWVKAHELKE
60 70 80 90 100
HNGHITGIDW APKSDRIVTC GADRNAYVWS QKDGVWKPTL VILRINRAAT
110 120 130 140 150
FVKWSPLENK FAVGSGARLI SVCYFESEND WWVSKHIKKP IRSTVLSLDW
160 170 180 190 200
HPNNVLLAAG SCDFKCRVFS AYIKEVDEKP ASTPWGSKMP FGQLMSEFGG
210 220 230 240 250
SGTGGWVHGV SFSASGSRLA WVSHDSTVSV ADASKSVQVS TLKTEFLPLL
260 270 280 290 300
SVSFVSENSV VAAGHDCCPM LFNYDDRGCL TFVSKLDIPK QSIQRNMSAM
310 320 330 340 350
ERFRNMDKRA TTEDRNTALE TLHQNSITQV SIYEVDKQDC RKFCTTGIDG
360 370
AMTIWDFKTL ESSIQGLRIM
Length:370
Mass (Da):41,569
Last modified:February 21, 2006 - v2
Checksum:i57FA5AC69997636E
GO
Isoform 2 (identifier: Q92747-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-57: MSLHQFLLEPITCHAWNRDRTQIALSPNNHEVHIYKKNGSQWVKAHELKEHNGHITG → MHERFIHCFC
     359-370: TLESSIQGLRIM → EPSRHGLPQLPGGAHQLPRLEQGPHPDCHLPQQP

Note: No experimental confirmation available.
Show »
Length:345
Mass (Da):38,603
Checksum:i84495A5242F16A89
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti127 – 1271S → A in CAA70203 (PubMed:8978670).Curated
Sequence conflicti180 – 1801P → K in CAA70203 (PubMed:8978670).Curated
Sequence conflicti273 – 2731N → I in CAA70203 (PubMed:8978670).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 5757MSLHQ…GHITG → MHERFIHCFC in isoform 2. 1 PublicationVSP_056389Add
BLAST
Alternative sequencei359 – 37012TLESS…GLRIM → EPSRHGLPQLPGGAHQLPRL EQGPHPDCHLPQQP in isoform 2. 1 PublicationVSP_056390Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08999 mRNA. Translation: CAA70203.1.
AK297111 mRNA. Translation: BAG59619.1.
AC004834 Genomic DNA. No translation available.
AC004922 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23883.1.
CH471091 Genomic DNA. Translation: EAW76682.1.
CH471091 Genomic DNA. Translation: EAW76683.1.
BC039594 mRNA. Translation: AAH39594.2.
BC047889 mRNA. Translation: AAH47889.2.
BC054027 mRNA. Translation: AAH54027.1.
CCDSiCCDS5660.1. [Q92747-1]
RefSeqiNP_006400.2. NM_006409.3. [Q92747-1]
UniGeneiHs.124126.

Genome annotation databases

EnsembliENST00000262942; ENSP00000262942; ENSG00000241685. [Q92747-1]
GeneIDi10552.
KEGGihsa:10552.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08999 mRNA. Translation: CAA70203.1.
AK297111 mRNA. Translation: BAG59619.1.
AC004834 Genomic DNA. No translation available.
AC004922 Genomic DNA. No translation available.
CH236956 Genomic DNA. Translation: EAL23883.1.
CH471091 Genomic DNA. Translation: EAW76682.1.
CH471091 Genomic DNA. Translation: EAW76683.1.
BC039594 mRNA. Translation: AAH39594.2.
BC047889 mRNA. Translation: AAH47889.2.
BC054027 mRNA. Translation: AAH54027.1.
CCDSiCCDS5660.1. [Q92747-1]
RefSeqiNP_006400.2. NM_006409.3. [Q92747-1]
UniGeneiHs.124126.

3D structure databases

ProteinModelPortaliQ92747.
SMRiQ92747. Positions 2-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115803. 34 interactions.
DIPiDIP-33142N.
IntActiQ92747. 6 interactions.
MINTiMINT-3049287.
STRINGi9606.ENSP00000262942.

PTM databases

iPTMnetiQ92747.
PhosphoSiteiQ92747.
SwissPalmiQ92747.

Polymorphism and mutation databases

BioMutaiARPC1A.
DMDMi88984001.

Proteomic databases

EPDiQ92747.
PaxDbiQ92747.
PeptideAtlasiQ92747.
PRIDEiQ92747.

Protocols and materials databases

DNASUi10552.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000262942; ENSP00000262942; ENSG00000241685. [Q92747-1]
GeneIDi10552.
KEGGihsa:10552.

Organism-specific databases

CTDi10552.
GeneCardsiARPC1A.
HGNCiHGNC:703. ARPC1A.
HPAiHPA004334.
MIMi604220. gene.
neXtProtiNX_Q92747.
PharmGKBiPA24997.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG1523. Eukaryota.
ENOG410XNWX. LUCA.
GeneTreeiENSGT00390000008339.
HOGENOMiHOG000181752.
HOVERGENiHBG050560.
InParanoidiQ92747.
KOiK05757.
OMAiISAMRIF.
OrthoDBiEOG091G096H.
PhylomeDBiQ92747.
TreeFamiTF315041.

Enzyme and pathway databases

ReactomeiR-HSA-2029482. Regulation of actin dynamics for phagocytic cup formation.
R-HSA-3928662. EPHB-mediated forward signaling.
R-HSA-5663213. RHO GTPases Activate WASPs and WAVEs.
SignaLinkiQ92747.

Miscellaneous databases

ChiTaRSiARPC1A. human.
GeneWikiiARPC1A.
GenomeRNAii10552.
PROiQ92747.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000241685.
CleanExiHS_ARPC1A.
ExpressionAtlasiQ92747. baseline and differential.
GenevisibleiQ92747. HS.

Family and domain databases

Gene3Di2.130.10.10. 1 hit.
InterProiIPR030140. ARC1A.
IPR017383. ARPC1.
IPR015943. WD40/YVTN_repeat-like_dom.
IPR001680. WD40_repeat.
IPR017986. WD40_repeat_dom.
[Graphical view]
PANTHERiPTHR10709. PTHR10709. 1 hit.
PTHR10709:SF11. PTHR10709:SF11. 1 hit.
PfamiPF00400. WD40. 2 hits.
[Graphical view]
PIRSFiPIRSF038093. ARP2/3_su1. 1 hit.
SMARTiSM00320. WD40. 6 hits.
[Graphical view]
SUPFAMiSSF50978. SSF50978. 1 hit.
PROSITEiPS50082. WD_REPEATS_2. 1 hit.
PS50294. WD_REPEATS_REGION. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiARC1A_HUMAN
AccessioniPrimary (citable) accession number: Q92747
Secondary accession number(s): A4D276
, B4DLQ7, D6W5S1, Q7Z5U8, Q86WU5, Q8IXQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 21, 2006
Last modified: September 7, 2016
This is version 143 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 7
    Human chromosome 7: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.