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Protein

Ras-like protein family member 10A

Gene

RASL10A

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Potent inhibitor of cellular proliferation.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi11 – 18GTPBy similarity8
Nucleotide bindingi59 – 62GTPBy similarity4
Nucleotide bindingi129 – 132GTPBy similarity4

GO - Molecular functioni

  • GTPase activity Source: ProtInc
  • GTP binding Source: UniProtKB-KW

GO - Biological processi

  • small GTPase mediated signal transduction Source: ProtInc
Complete GO annotation...

Keywords - Ligandi

GTP-binding, Nucleotide-binding

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100276-MONOMER.

Names & Taxonomyi

Protein namesi
Recommended name:
Ras-like protein family member 10A
Alternative name(s):
Ras-like protein RRP22
Ras-related protein on chromosome 22
Gene namesi
Name:RASL10A
Synonyms:RRP22
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 22

Organism-specific databases

HGNCiHGNC:16954. RASL10A.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane, Nucleus

Pathology & Biotechi

Keywords - Diseasei

Tumor suppressor

Organism-specific databases

DisGeNETi10633.
OpenTargetsiENSG00000100276.
PharmGKBiPA162400707.

Polymorphism and mutation databases

BioMutaiRASL10A.
DMDMi3024572.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000827061 – 200Ras-like protein family member 10AAdd BLAST200
PropeptideiPRO_0000281360201 – 203Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei200Cysteine methyl esterBy similarity1
Lipidationi200S-farnesyl cysteine1 Publication1

Post-translational modificationi

Isoprenylation is essential for nucleolar localization, and the proliferation-inhibiting activity of RASL10A.1 Publication

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ92737.
PeptideAtlasiQ92737.
PRIDEiQ92737.

Expressioni

Tissue specificityi

Expression appears to be strictly limited to the central nervous system.1 Publication

Gene expression databases

BgeeiENSG00000100276.
CleanExiHS_RASL10A.
ExpressionAtlasiQ92737. baseline and differential.
GenevisibleiQ92737. HS.

Organism-specific databases

HPAiHPA056169.

Interactioni

Protein-protein interaction databases

BioGridi115877. 5 interactors.
STRINGi9606.ENSP00000216101.

Structurei

3D structure databases

ProteinModelPortaliQ92737.
SMRiQ92737.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 203Small GTPase-likeAdd BLAST203

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi33 – 42Effector regionCurated10

Sequence similaritiesi

Belongs to the small GTPase superfamily. Ras family.Curated

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133830.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ92737.
KOiK07850.
OMAiLEEWPDP.
OrthoDBiEOG091G0JOZ.
PhylomeDBiQ92737.
TreeFamiTF325043.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92737-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MGGSLRVAVL GAPGVGKTAI IRQFLFGDYP ERHRPTDGPR LYRPAVLLDG
60 70 80 90 100
AVYDLSIRDG DVAGPGSSPG GPEEWPDAKD WSLQDTDAFV LVYDICSPDS
110 120 130 140 150
FDYVKALRQR IAETRPAGAP EAPILVVGNK RDRQRLRFGP RRALAALVRR
160 170 180 190 200
GWRCGYLECS AKYNWHVLRL FRELLRCALV RARPAHPALR LQGALHPARC

SLM
Length:203
Mass (Da):22,541
Last modified:February 1, 1997 - v1
Checksum:iD11B33EE019E2D78
GO
Isoform 2 (identifier: Q92737-2) [UniParc]FASTAAdd to basket
Also known as: B

The sequence of this isoform differs from the canonical sequence as follows:
     116-203: Missing.

Show »
Length:115
Mass (Da):12,537
Checksum:i1258DC9D43777BA5
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti25L → V in AAH22473 (PubMed:15489334).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_013372116 – 203Missing in isoform 2. 1 PublicationAdd BLAST88

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07847 mRNA. Translation: CAA69175.1.
AC002059 Genomic DNA. No translation available.
BC022473 mRNA. Translation: AAH22473.1.
BC040434 mRNA. Translation: AAH40434.1.
BC050739 mRNA. Translation: AAH50739.1.
BC058077 mRNA. Translation: AAH58077.1.
CCDSiCCDS13854.1. [Q92737-1]
RefSeqiNP_006468.1. NM_006477.4. [Q92737-1]
UniGeneiHs.73088.

Genome annotation databases

EnsembliENST00000216101; ENSP00000216101; ENSG00000100276. [Q92737-1]
ENST00000401450; ENSP00000386095; ENSG00000100276. [Q92737-2]
GeneIDi10633.
KEGGihsa:10633.
UCSCiuc003aff.4. human. [Q92737-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07847 mRNA. Translation: CAA69175.1.
AC002059 Genomic DNA. No translation available.
BC022473 mRNA. Translation: AAH22473.1.
BC040434 mRNA. Translation: AAH40434.1.
BC050739 mRNA. Translation: AAH50739.1.
BC058077 mRNA. Translation: AAH58077.1.
CCDSiCCDS13854.1. [Q92737-1]
RefSeqiNP_006468.1. NM_006477.4. [Q92737-1]
UniGeneiHs.73088.

3D structure databases

ProteinModelPortaliQ92737.
SMRiQ92737.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115877. 5 interactors.
STRINGi9606.ENSP00000216101.

Polymorphism and mutation databases

BioMutaiRASL10A.
DMDMi3024572.

Proteomic databases

PaxDbiQ92737.
PeptideAtlasiQ92737.
PRIDEiQ92737.

Protocols and materials databases

DNASUi10633.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216101; ENSP00000216101; ENSG00000100276. [Q92737-1]
ENST00000401450; ENSP00000386095; ENSG00000100276. [Q92737-2]
GeneIDi10633.
KEGGihsa:10633.
UCSCiuc003aff.4. human. [Q92737-1]

Organism-specific databases

CTDi10633.
DisGeNETi10633.
GeneCardsiRASL10A.
HGNCiHGNC:16954. RASL10A.
HPAiHPA056169.
MIMi602220. gene.
neXtProtiNX_Q92737.
OpenTargetsiENSG00000100276.
PharmGKBiPA162400707.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0395. Eukaryota.
COG1100. LUCA.
GeneTreeiENSGT00860000133830.
HOGENOMiHOG000233973.
HOVERGENiHBG009351.
InParanoidiQ92737.
KOiK07850.
OMAiLEEWPDP.
OrthoDBiEOG091G0JOZ.
PhylomeDBiQ92737.
TreeFamiTF325043.

Enzyme and pathway databases

BioCyciZFISH:ENSG00000100276-MONOMER.

Miscellaneous databases

ChiTaRSiRASL10A. human.
GenomeRNAii10633.
PROiQ92737.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100276.
CleanExiHS_RASL10A.
ExpressionAtlasiQ92737. baseline and differential.
GenevisibleiQ92737. HS.

Family and domain databases

Gene3Di3.40.50.300. 1 hit.
InterProiIPR027417. P-loop_NTPase.
IPR001806. Small_GTPase.
IPR020849. Small_GTPase_Ras.
[Graphical view]
PANTHERiPTHR24070. PTHR24070. 1 hit.
PfamiPF00071. Ras. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 1 hit.
PROSITEiPS51421. RAS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiRSLAA_HUMAN
AccessioniPrimary (citable) accession number: Q92737
Secondary accession number(s): Q49AU5, Q6PI03
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 15, 1998
Last sequence update: February 1, 1997
Last modified: November 30, 2016
This is version 144 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 22
    Human chromosome 22: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.