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Q92734

- TFG_HUMAN

UniProt

Q92734 - TFG_HUMAN

Protein

Protein TFG

Gene

TFG

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 126 (01 Oct 2014)
      Sequence version 2 (10 Feb 2009)
      Previous versions | rss
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    Functioni

    Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.1 Publication

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei193 – 1942Breakpoint for translocation to form TRK-T3

    GO - Molecular functioni

    1. protein binding Source: IntAct
    2. signal transducer activity Source: UniProtKB

    GO - Biological processi

    1. cell death Source: UniProtKB-KW
    2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
    3. signal transduction Source: GOC

    Enzyme and pathway databases

    SignaLinkiQ92734.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein TFG
    Alternative name(s):
    TRK-fused gene protein
    Gene namesi
    Name:TFG
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:11758. TFG.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. extracellular vesicular exosome Source: UniProt

    Pathology & Biotechi

    Involvement in diseasei

    Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells.
    Note: The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.
    Hereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti285 – 2851P → L in HMSNP; results in mislocalization and TARDBP-inclusion-body formation in cultured cells. 1 Publication
    VAR_068917
    Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations.1 Publication
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti106 – 1061R → C in SPG57; defective self-assembly into an oligomeric complex. 1 Publication
    VAR_070986

    Keywords - Diseasei

    Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy, Proto-oncogene

    Organism-specific databases

    MIMi188550. phenotype.
    604484. phenotype.
    615658. phenotype.
    Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
    90117. Hereditary motor and sensory neuropathy, Okinawa type.
    146. Papillary or follicular thyroid carcinoma.
    320406. Spastic paraplegia-optic atrophy-neuropathy syndrome.
    PharmGKBiPA36473.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 400400Protein TFGPRO_0000072500Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine3 Publications
    Modified residuei197 – 1971Phosphoserine2 Publications

    Keywords - PTMi

    Acetylation, Phosphoprotein

    Proteomic databases

    MaxQBiQ92734.
    PaxDbiQ92734.
    PRIDEiQ92734.

    PTM databases

    PhosphoSiteiQ92734.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ92734.
    BgeeiQ92734.
    CleanExiHS_TFG.
    GenevestigatoriQ92734.

    Organism-specific databases

    HPAiHPA019473.
    HPA052206.

    Interactioni

    Subunit structurei

    Self-associates to form an oligomeric complex.1 Publication

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    PLSCR1O151622EBI-357061,EBI-740019

    Protein-protein interaction databases

    BioGridi115624. 38 interactions.
    IntActiQ92734. 21 interactions.
    MINTiMINT-1156489.
    STRINGi9606.ENSP00000240851.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92734.
    SMRiQ92734. Positions 9-89.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili97 – 12428Sequence AnalysisAdd
    BLAST

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG85275.
    HOGENOMiHOG000132915.
    HOVERGENiHBG009087.
    InParanoidiQ92734.
    KOiK09292.
    OMAiIQYSAGY.
    OrthoDBiEOG7TXKJH.
    PhylomeDBiQ92734.
    TreeFamiTF318743.

    Family and domain databases

    InterProiIPR000270. OPR_PB1.
    [Graphical view]
    PfamiPF00564. PB1. 1 hit.
    [Graphical view]
    SMARTiSM00666. PB1. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92734-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS    50
    NDEVTIKYKD EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS 100
    QVKYLRRELI ELRNKVNRLL DSLEPPGEPG PSTNIPENDT VDGREEKSAS 150
    DSSGKQSTQV MAASMSAFDP LKNQDEINKN VMSAFGLTDD QVSGPPSAPA 200
    EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE GQMYQQYQQQ 250
    AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP 300
    APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA 350
    PSQPGAYQPR PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR 400
    Length:400
    Mass (Da):43,448
    Last modified:February 10, 2009 - v2
    Checksum:iD8A559D0F7314D1F
    GO
    Isoform 2 (identifier: Q92734-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         237-240: Missing.

    Note: No experimental confirmation available.

    Show »
    Length:396
    Mass (Da):43,020
    Checksum:iE4FF3B134949F61C
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti13 – 131I → V in CAA69264. (PubMed:9169129)Curated
    Sequence conflicti13 – 131I → V in CAA59936. (PubMed:7565764)Curated

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti43 – 431V → F.
    Corresponds to variant rs15245 [ dbSNP | Ensembl ].
    VAR_059731
    Natural varianti106 – 1061R → C in SPG57; defective self-assembly into an oligomeric complex. 1 Publication
    VAR_070986
    Natural varianti149 – 1491A → S in a colorectal cancer sample; somatic mutation. 1 Publication
    VAR_035668
    Natural varianti211 – 2111A → V.
    Corresponds to variant rs430945 [ dbSNP | Ensembl ].
    VAR_054322
    Natural varianti285 – 2851P → L in HMSNP; results in mislocalization and TARDBP-inclusion-body formation in cultured cells. 1 Publication
    VAR_068917
    Natural varianti364 – 3641T → P.
    Corresponds to variant rs6772054 [ dbSNP | Ensembl ].
    VAR_054323

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei237 – 2404Missing in isoform 2. CuratedVSP_047131

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07968 mRNA. Translation: CAA69264.1.
    AK093456 mRNA. Translation: BAG52721.1.
    BT007428 mRNA. Translation: AAP36096.1.
    CR456781 mRNA. Translation: CAG33062.1.
    AC068763 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79813.1.
    CH471052 Genomic DNA. Translation: EAW79814.1.
    CH471052 Genomic DNA. Translation: EAW79815.1.
    CH471052 Genomic DNA. Translation: EAW79816.1.
    CH471052 Genomic DNA. Translation: EAW79817.1.
    BC001483 mRNA. Translation: AAH01483.1.
    BC009241 mRNA. Translation: AAH09241.1.
    BC023599 mRNA. Translation: AAH23599.1.
    X85960 mRNA. Translation: CAA59936.1. Different termination.
    CCDSiCCDS2939.1. [Q92734-1]
    CCDS56266.1. [Q92734-2]
    RefSeqiNP_001007566.1. NM_001007565.2. [Q92734-1]
    NP_001182407.1. NM_001195478.1. [Q92734-1]
    NP_001182408.1. NM_001195479.1. [Q92734-2]
    NP_006061.2. NM_006070.5. [Q92734-1]
    XP_005247123.1. XM_005247066.1. [Q92734-2]
    XP_006713535.1. XM_006713472.1. [Q92734-1]
    XP_006713536.1. XM_006713473.1. [Q92734-1]
    UniGeneiHs.518123.

    Genome annotation databases

    EnsembliENST00000240851; ENSP00000240851; ENSG00000114354. [Q92734-1]
    ENST00000418917; ENSP00000397182; ENSG00000114354. [Q92734-2]
    ENST00000476228; ENSP00000417952; ENSG00000114354. [Q92734-2]
    ENST00000490574; ENSP00000419960; ENSG00000114354. [Q92734-1]
    GeneIDi10342.
    KEGGihsa:10342.
    UCSCiuc003due.3. human. [Q92734-1]
    uc003dug.3. human.

    Polymorphism databases

    DMDMi223634676.

    Keywords - Coding sequence diversityi

    Alternative splicing, Chromosomal rearrangement, Polymorphism

    Cross-referencesi

    Web resourcesi

    Atlas of Genetics and Cytogenetics in Oncology and Haematology

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y07968 mRNA. Translation: CAA69264.1 .
    AK093456 mRNA. Translation: BAG52721.1 .
    BT007428 mRNA. Translation: AAP36096.1 .
    CR456781 mRNA. Translation: CAG33062.1 .
    AC068763 Genomic DNA. No translation available.
    CH471052 Genomic DNA. Translation: EAW79813.1 .
    CH471052 Genomic DNA. Translation: EAW79814.1 .
    CH471052 Genomic DNA. Translation: EAW79815.1 .
    CH471052 Genomic DNA. Translation: EAW79816.1 .
    CH471052 Genomic DNA. Translation: EAW79817.1 .
    BC001483 mRNA. Translation: AAH01483.1 .
    BC009241 mRNA. Translation: AAH09241.1 .
    BC023599 mRNA. Translation: AAH23599.1 .
    X85960 mRNA. Translation: CAA59936.1 . Different termination.
    CCDSi CCDS2939.1. [Q92734-1 ]
    CCDS56266.1. [Q92734-2 ]
    RefSeqi NP_001007566.1. NM_001007565.2. [Q92734-1 ]
    NP_001182407.1. NM_001195478.1. [Q92734-1 ]
    NP_001182408.1. NM_001195479.1. [Q92734-2 ]
    NP_006061.2. NM_006070.5. [Q92734-1 ]
    XP_005247123.1. XM_005247066.1. [Q92734-2 ]
    XP_006713535.1. XM_006713472.1. [Q92734-1 ]
    XP_006713536.1. XM_006713473.1. [Q92734-1 ]
    UniGenei Hs.518123.

    3D structure databases

    ProteinModelPortali Q92734.
    SMRi Q92734. Positions 9-89.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115624. 38 interactions.
    IntActi Q92734. 21 interactions.
    MINTi MINT-1156489.
    STRINGi 9606.ENSP00000240851.

    PTM databases

    PhosphoSitei Q92734.

    Polymorphism databases

    DMDMi 223634676.

    Proteomic databases

    MaxQBi Q92734.
    PaxDbi Q92734.
    PRIDEi Q92734.

    Protocols and materials databases

    DNASUi 10342.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000240851 ; ENSP00000240851 ; ENSG00000114354 . [Q92734-1 ]
    ENST00000418917 ; ENSP00000397182 ; ENSG00000114354 . [Q92734-2 ]
    ENST00000476228 ; ENSP00000417952 ; ENSG00000114354 . [Q92734-2 ]
    ENST00000490574 ; ENSP00000419960 ; ENSG00000114354 . [Q92734-1 ]
    GeneIDi 10342.
    KEGGi hsa:10342.
    UCSCi uc003due.3. human. [Q92734-1 ]
    uc003dug.3. human.

    Organism-specific databases

    CTDi 10342.
    GeneCardsi GC03P100428.
    H-InvDB HIX0003505.
    HGNCi HGNC:11758. TFG.
    HPAi HPA019473.
    HPA052206.
    MIMi 188550. phenotype.
    602498. gene.
    604484. phenotype.
    615658. phenotype.
    neXtProti NX_Q92734.
    Orphaneti 209916. Extraskeletal myxoid chondrosarcoma.
    90117. Hereditary motor and sensory neuropathy, Okinawa type.
    146. Papillary or follicular thyroid carcinoma.
    320406. Spastic paraplegia-optic atrophy-neuropathy syndrome.
    PharmGKBi PA36473.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG85275.
    HOGENOMi HOG000132915.
    HOVERGENi HBG009087.
    InParanoidi Q92734.
    KOi K09292.
    OMAi IQYSAGY.
    OrthoDBi EOG7TXKJH.
    PhylomeDBi Q92734.
    TreeFami TF318743.

    Enzyme and pathway databases

    SignaLinki Q92734.

    Miscellaneous databases

    ChiTaRSi TFG. human.
    GeneWikii TFG_(gene).
    GenomeRNAii 10342.
    NextBioi 18907.
    PROi Q92734.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92734.
    Bgeei Q92734.
    CleanExi HS_TFG.
    Genevestigatori Q92734.

    Family and domain databases

    InterProi IPR000270. OPR_PB1.
    [Graphical view ]
    Pfami PF00564. PB1. 1 hit.
    [Graphical view ]
    SMARTi SM00666. PB1. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma."
      Mencinger M., Panagopoluos I., Andreasson P., Lassen C., Mitelman F., Aman P.
      Genomics 41:327-331(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Pancreas.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Testis.
    3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    5. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain, Placenta and Uterus.
    8. "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain."
      Greco A., Mariani C., Miranda C., Lupas A., Pagliardini S., Pomati M., Pierotti M.A.
      Mol. Cell. Biol. 15:6118-6127(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-193, CHROMOSOMAL TRANSLOCATION WITH NTRK1.
    9. Bienvenut W.V., Calvo F., Kolch W.
      Submitted (FEB-2008) to UniProtKB
      Cited for: PROTEIN SEQUENCE OF 1-10; 15-22; 24-42 AND 48-57, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
      Tissue: Cervix carcinoma.
    10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
      Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
      Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Leukemic T-cell.
    13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
      Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
      Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    15. Cited for: FUNCTION, SUBUNIT, VARIANT SPG57 CYS-106, CHARACTERIZATION OF VARIANT SPG57 CYS-106.
    16. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-149.
    17. Cited for: VARIANT HMSNP LEU-285, CHARACTERIZATION OF VARIANT HMSNP LEU-285.

    Entry informationi

    Entry nameiTFG_HUMAN
    AccessioniPrimary (citable) accession number: Q92734
    Secondary accession number(s): D3DN49
    , G5E9V1, Q15656, Q969I2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: February 2, 2004
    Last sequence update: February 10, 2009
    Last modified: October 1, 2014
    This is version 126 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Direct protein sequencing, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

    External Data

    Dasty 3