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Protein

Protein TFG

Gene

TFG

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei193 – 1942Breakpoint for translocation to form TRK-T3

GO - Molecular functioni

  • signal transducer activity Source: UniProtKB

GO - Biological processi

  • positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  • signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ92734.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TFG
Alternative name(s):
TRK-fused gene protein
Gene namesi
Name:TFG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 3

Organism-specific databases

HGNCiHGNC:11758. TFG.

Subcellular locationi

GO - Cellular componenti

  • cytoplasm Source: UniProtKB
  • extracellular exosome Source: UniProtKB
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Thyroid papillary carcinoma (TPC)

The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.

Disease descriptionA common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells.

See also OMIM:188550
Hereditary motor and sensory neuropathy, proximal type (HMSNP)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis.

See also OMIM:604484
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti285 – 2851P → L in HMSNP; results in mislocalization and TARDBP-inclusion-body formation in cultured cells. 1 Publication
VAR_068917
Spastic paraplegia 57, autosomal recessive (SPG57)1 Publication

The disease is caused by mutations affecting the gene represented in this entry.

Disease descriptionA complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations.

See also OMIM:615658
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061R → C in SPG57; defective self-assembly into an oligomeric complex. 1 Publication
VAR_070986

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy, Proto-oncogene

Organism-specific databases

MIMi188550. phenotype.
604484. phenotype.
615658. phenotype.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
90117. Hereditary motor and sensory neuropathy, Okinawa type.
146. Papillary or follicular thyroid carcinoma.
320406. Spastic paraplegia-optic atrophy-neuropathy syndrome.
PharmGKBiPA36473.

Polymorphism and mutation databases

BioMutaiTFG.
DMDMi223634676.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Protein TFGPRO_0000072500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei197 – 1971Phosphoserine3 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92734.
PaxDbiQ92734.
PRIDEiQ92734.

PTM databases

PhosphoSiteiQ92734.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ92734.
CleanExiHS_TFG.
ExpressionAtlasiQ92734. baseline and differential.
GenevisibleiQ92734. HS.

Organism-specific databases

HPAiHPA019473.
HPA052206.

Interactioni

Subunit structurei

Self-associates to form an oligomeric complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
ANXA11Q5T0G83EBI-357061,EBI-10245225
ARHGEF16Q5VV413EBI-357061,EBI-1057448
BOLLQ8N9W64EBI-357061,EBI-998198
CEP55D3DR373EBI-357061,EBI-10173536
CSTF2P332403EBI-357061,EBI-711360
EWSR1Q018443EBI-357061,EBI-739737
HNRNPFP525973EBI-357061,EBI-352986
MAGED1Q9Y5V35EBI-357061,EBI-716006
MAPK1IP1LQ8NDC03EBI-357061,EBI-741424
PEF1Q9UBV83EBI-357061,EBI-724639
PLSCR1O151622EBI-357061,EBI-740019
RBPMSQ930623EBI-357061,EBI-740322
SEC24AO954863EBI-357061,EBI-749911
SPG21Q9NZD83EBI-357061,EBI-742688
VPS37CA5D8V63EBI-357061,EBI-2559305

Protein-protein interaction databases

BioGridi115624. 68 interactions.
IntActiQ92734. 35 interactions.
MINTiMINT-1156489.
STRINGi9606.ENSP00000240851.

Structurei

3D structure databases

ProteinModelPortaliQ92734.
SMRiQ92734. Positions 11-91.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini10 – 9182PB1PROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili97 – 12428Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Contains 1 PB1 domain.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85275.
GeneTreeiENSGT00510000047809.
HOGENOMiHOG000132915.
HOVERGENiHBG009087.
InParanoidiQ92734.
KOiK09292.
OMAiIQYSAGY.
OrthoDBiEOG7TXKJH.
PhylomeDBiQ92734.
TreeFamiTF318743.

Family and domain databases

InterProiIPR000270. PB1_dom.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
[Graphical view]
PROSITEiPS51745. PB1. 1 hit.
[Graphical view]

Sequences (4)i

Sequence statusi: Complete.

This entry describes 4 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92734-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS
60 70 80 90 100
NDEVTIKYKD EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS
110 120 130 140 150
QVKYLRRELI ELRNKVNRLL DSLEPPGEPG PSTNIPENDT VDGREEKSAS
160 170 180 190 200
DSSGKQSTQV MAASMSAFDP LKNQDEINKN VMSAFGLTDD QVSGPPSAPA
210 220 230 240 250
EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE GQMYQQYQQQ
260 270 280 290 300
AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP
310 320 330 340 350
APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA
360 370 380 390 400
PSQPGAYQPR PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR
Length:400
Mass (Da):43,448
Last modified:February 10, 2009 - v2
Checksum:iD8A559D0F7314D1F
GO
Isoform 2 (identifier: Q92734-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-240: Missing.

Note: No experimental confirmation available.
Show »
Length:396
Mass (Da):43,020
Checksum:iE4FF3B134949F61C
GO
Isoform 3 (identifier: Q92734-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     274-284: ASYSQQTGPQQ → GFQSMERFHCK
     285-400: Missing.

Show »
Length:284
Mass (Da):31,349
Checksum:iCCE52A4FFE1C9208
GO
Isoform 4 (identifier: Q92734-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-240: Missing.
     274-284: ASYSQQTGPQQ → GFQSMERFHCK
     285-400: Missing.

Show »
Length:280
Mass (Da):30,921
Checksum:i15A1AE17A24AD3C9
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131I → V in CAA69264 (PubMed:9169129).Curated
Sequence conflicti13 – 131I → V in CAA59936 (PubMed:7565764).Curated

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431V → F.
Corresponds to variant rs15245 [ dbSNP | Ensembl ].
VAR_059731
Natural varianti106 – 1061R → C in SPG57; defective self-assembly into an oligomeric complex. 1 Publication
VAR_070986
Natural varianti149 – 1491A → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035668
Natural varianti211 – 2111A → V.
Corresponds to variant rs430945 [ dbSNP | Ensembl ].
VAR_054322
Natural varianti285 – 2851P → L in HMSNP; results in mislocalization and TARDBP-inclusion-body formation in cultured cells. 1 Publication
VAR_068917
Natural varianti364 – 3641T → P.
Corresponds to variant rs6772054 [ dbSNP | Ensembl ].
VAR_054323

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 2404Missing in isoform 2 and isoform 4. CuratedVSP_047131
Alternative sequencei274 – 28411ASYSQQTGPQQ → GFQSMERFHCK in isoform 3 and isoform 4. 1 PublicationVSP_057414Add
BLAST
Alternative sequencei285 – 400116Missing in isoform 3 and isoform 4. 1 PublicationVSP_057415Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07968 mRNA. Translation: CAA69264.1.
AB731569 mRNA. Translation: BAM48926.1.
AB731570 mRNA. Translation: BAM48927.1.
AK093456 mRNA. Translation: BAG52721.1.
BT007428 mRNA. Translation: AAP36096.1.
CR456781 mRNA. Translation: CAG33062.1.
AC068763 Genomic DNA. No translation available.
KF457659 Genomic DNA. No translation available.
KF457666 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79813.1.
CH471052 Genomic DNA. Translation: EAW79814.1.
CH471052 Genomic DNA. Translation: EAW79815.1.
CH471052 Genomic DNA. Translation: EAW79816.1.
CH471052 Genomic DNA. Translation: EAW79817.1.
BC001483 mRNA. Translation: AAH01483.1.
BC009241 mRNA. Translation: AAH09241.1.
BC023599 mRNA. Translation: AAH23599.1.
X85960 mRNA. Translation: CAA59936.1. Different termination.
CCDSiCCDS2939.1. [Q92734-1]
CCDS56266.1. [Q92734-2]
RefSeqiNP_001007566.1. NM_001007565.2. [Q92734-1]
NP_001182407.1. NM_001195478.1. [Q92734-1]
NP_001182408.1. NM_001195479.1. [Q92734-2]
NP_006061.2. NM_006070.5. [Q92734-1]
XP_005247123.1. XM_005247066.1. [Q92734-2]
XP_006713535.1. XM_006713472.1. [Q92734-1]
XP_006713536.1. XM_006713473.1. [Q92734-1]
UniGeneiHs.518123.

Genome annotation databases

EnsembliENST00000240851; ENSP00000240851; ENSG00000114354. [Q92734-1]
ENST00000418917; ENSP00000397182; ENSG00000114354. [Q92734-2]
ENST00000476228; ENSP00000417952; ENSG00000114354. [Q92734-2]
ENST00000490574; ENSP00000419960; ENSG00000114354. [Q92734-1]
ENST00000615993; ENSP00000479269; ENSG00000114354. [Q92734-3]
ENST00000620299; ENSP00000479981; ENSG00000114354. [Q92734-3]
GeneIDi10342.
KEGGihsa:10342.
UCSCiuc003due.3. human. [Q92734-1]
uc003dug.3. human.
uc031sau.1. human.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07968 mRNA. Translation: CAA69264.1.
AB731569 mRNA. Translation: BAM48926.1.
AB731570 mRNA. Translation: BAM48927.1.
AK093456 mRNA. Translation: BAG52721.1.
BT007428 mRNA. Translation: AAP36096.1.
CR456781 mRNA. Translation: CAG33062.1.
AC068763 Genomic DNA. No translation available.
KF457659 Genomic DNA. No translation available.
KF457666 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79813.1.
CH471052 Genomic DNA. Translation: EAW79814.1.
CH471052 Genomic DNA. Translation: EAW79815.1.
CH471052 Genomic DNA. Translation: EAW79816.1.
CH471052 Genomic DNA. Translation: EAW79817.1.
BC001483 mRNA. Translation: AAH01483.1.
BC009241 mRNA. Translation: AAH09241.1.
BC023599 mRNA. Translation: AAH23599.1.
X85960 mRNA. Translation: CAA59936.1. Different termination.
CCDSiCCDS2939.1. [Q92734-1]
CCDS56266.1. [Q92734-2]
RefSeqiNP_001007566.1. NM_001007565.2. [Q92734-1]
NP_001182407.1. NM_001195478.1. [Q92734-1]
NP_001182408.1. NM_001195479.1. [Q92734-2]
NP_006061.2. NM_006070.5. [Q92734-1]
XP_005247123.1. XM_005247066.1. [Q92734-2]
XP_006713535.1. XM_006713472.1. [Q92734-1]
XP_006713536.1. XM_006713473.1. [Q92734-1]
UniGeneiHs.518123.

3D structure databases

ProteinModelPortaliQ92734.
SMRiQ92734. Positions 11-91.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi115624. 68 interactions.
IntActiQ92734. 35 interactions.
MINTiMINT-1156489.
STRINGi9606.ENSP00000240851.

PTM databases

PhosphoSiteiQ92734.

Polymorphism and mutation databases

BioMutaiTFG.
DMDMi223634676.

Proteomic databases

MaxQBiQ92734.
PaxDbiQ92734.
PRIDEiQ92734.

Protocols and materials databases

DNASUi10342.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000240851; ENSP00000240851; ENSG00000114354. [Q92734-1]
ENST00000418917; ENSP00000397182; ENSG00000114354. [Q92734-2]
ENST00000476228; ENSP00000417952; ENSG00000114354. [Q92734-2]
ENST00000490574; ENSP00000419960; ENSG00000114354. [Q92734-1]
ENST00000615993; ENSP00000479269; ENSG00000114354. [Q92734-3]
ENST00000620299; ENSP00000479981; ENSG00000114354. [Q92734-3]
GeneIDi10342.
KEGGihsa:10342.
UCSCiuc003due.3. human. [Q92734-1]
uc003dug.3. human.
uc031sau.1. human.

Organism-specific databases

CTDi10342.
GeneCardsiGC03P100428.
H-InvDBHIX0003505.
HGNCiHGNC:11758. TFG.
HPAiHPA019473.
HPA052206.
MIMi188550. phenotype.
602498. gene.
604484. phenotype.
615658. phenotype.
neXtProtiNX_Q92734.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
90117. Hereditary motor and sensory neuropathy, Okinawa type.
146. Papillary or follicular thyroid carcinoma.
320406. Spastic paraplegia-optic atrophy-neuropathy syndrome.
PharmGKBiPA36473.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG85275.
GeneTreeiENSGT00510000047809.
HOGENOMiHOG000132915.
HOVERGENiHBG009087.
InParanoidiQ92734.
KOiK09292.
OMAiIQYSAGY.
OrthoDBiEOG7TXKJH.
PhylomeDBiQ92734.
TreeFamiTF318743.

Enzyme and pathway databases

SignaLinkiQ92734.

Miscellaneous databases

ChiTaRSiTFG. human.
GeneWikiiTFG_(gene).
GenomeRNAii10342.
NextBioi39217.
PROiQ92734.
SOURCEiSearch...

Gene expression databases

BgeeiQ92734.
CleanExiHS_TFG.
ExpressionAtlasiQ92734. baseline and differential.
GenevisibleiQ92734. HS.

Family and domain databases

InterProiIPR000270. PB1_dom.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
[Graphical view]
PROSITEiPS51745. PB1. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma."
    Mencinger M., Panagopoluos I., Andreasson P., Lassen C., Mitelman F., Aman P.
    Genomics 41:327-331(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  2. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 3 AND 4), VARIANT HMSNP LEU-285, CHARACTERIZATION OF VARIANT HMSNP LEU-285, ALTERNATIVE SPLICING.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  4. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  6. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  8. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Placenta and Uterus.
  9. "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain."
    Greco A., Mariani C., Miranda C., Lupas A., Pagliardini S., Pomati M., Pierotti M.A.
    Mol. Cell. Biol. 15:6118-6127(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-193, CHROMOSOMAL TRANSLOCATION WITH NTRK1.
  10. Bienvenut W.V., Calvo F., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-10; 15-22; 24-42 AND 48-57, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  14. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  16. Cited for: FUNCTION, SUBUNIT, VARIANT SPG57 CYS-106, CHARACTERIZATION OF VARIANT SPG57 CYS-106.
  17. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  18. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-149.

Entry informationi

Entry nameiTFG_HUMAN
AccessioniPrimary (citable) accession number: Q92734
Secondary accession number(s): D3DN49
, G5E9V1, K0J5S8, K0J6K2, Q15656, Q969I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 10, 2009
Last modified: June 24, 2015
This is version 135 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.