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Q92734

- TFG_HUMAN

UniProt

Q92734 - TFG_HUMAN

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Protein
Protein TFG
Gene
TFG
Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Plays a role in the normal dynamic function of the endoplasmic reticulum (ER) and its associated microtubules.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei193 – 1942Breakpoint for translocation to form TRK-T3

GO - Molecular functioni

  1. protein binding Source: IntAct
  2. signal transducer activity Source: UniProtKB

GO - Biological processi

  1. cell death Source: UniProtKB-KW
  2. positive regulation of I-kappaB kinase/NF-kappaB signaling Source: UniProtKB
  3. signal transduction Source: GOC
Complete GO annotation...

Enzyme and pathway databases

SignaLinkiQ92734.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein TFG
Alternative name(s):
TRK-fused gene protein
Gene namesi
Name:TFG
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640: Chromosome 3

Organism-specific databases

HGNCiHGNC:11758. TFG.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. extracellular vesicular exosome Source: UniProt
Complete GO annotation...

Pathology & Biotechi

Involvement in diseasei

Thyroid papillary carcinoma (TPC) [MIM:188550]: A common tumor of the thyroid that typically arises as an irregular, solid or cystic mass from otherwise normal thyroid tissue. Papillary carcinomas are malignant neoplasm characterized by the formation of numerous, irregular, finger-like projections of fibrous stroma that is covered with a surface layer of neoplastic epithelial cells.
Note: The gene represented in this entry may be involved in disease pathogenesis. A chromosomal aberration involving TFG is found in thyroid papillary carcinomas. Translocation t(1;3)(q21;q11) with NTRK1. The TFG sequence is fused to the 3'-end of NTRK1 generating the TRKT3 (TRK-T3) fusion transcript.
Hereditary motor and sensory neuropathy, proximal type (HMSNP) [MIM:604484]: A neurodegenerative disorder characterized by young adult onset of proximal muscle weakness and atrophy, muscle cramps, and fasciculations, with later onset of distal sensory impairment. The disorder is slowly progressive and clinically resembles amyotrophic lateral sclerosis.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti285 – 2851P → L in HMSNP; results in mislocalization and TARDBP-inclusion-body formation in cultured cells. 1 Publication
VAR_068917
Spastic paraplegia 57, autosomal recessive (SPG57) [MIM:615658]: A complicated form of spastic paraplegia, a neurodegenerative disorder characterized by a slow, gradual, progressive weakness and spasticity of the lower limbs. Rate of progression and the severity of symptoms are quite variable. Initial symptoms may include difficulty with balance, weakness and stiffness in the legs, muscle spasms, and dragging the toes when walking. Complicated forms are recognized by additional variable features including spastic quadriparesis, seizures, dementia, amyotrophy, extrapyramidal disturbance, cerebral or cerebellar atrophy, optic atrophy, and peripheral neuropathy, as well as by extra neurological manifestations.
Note: The disease is caused by mutations affecting the gene represented in this entry.1 Publication
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti106 – 1061R → C in SPG57; defective self-assembly into an oligomeric complex. 1 Publication
VAR_070986

Keywords - Diseasei

Disease mutation, Hereditary spastic paraplegia, Neurodegeneration, Neuropathy, Proto-oncogene

Organism-specific databases

MIMi188550. phenotype.
604484. phenotype.
615658. phenotype.
Orphaneti209916. Extraskeletal myxoid chondrosarcoma.
90117. Hereditary motor and sensory neuropathy, Okinawa type.
146. Papillary or follicular thyroid carcinoma.
320406. Spastic paraplegia-optic atrophy-neuropathy syndrome.
PharmGKBiPA36473.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 400400Protein TFG
PRO_0000072500Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionine3 Publications
Modified residuei197 – 1971Phosphoserine2 Publications

Keywords - PTMi

Acetylation, Phosphoprotein

Proteomic databases

MaxQBiQ92734.
PaxDbiQ92734.
PRIDEiQ92734.

PTM databases

PhosphoSiteiQ92734.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

ArrayExpressiQ92734.
BgeeiQ92734.
CleanExiHS_TFG.
GenevestigatoriQ92734.

Organism-specific databases

HPAiHPA019473.
HPA052206.

Interactioni

Subunit structurei

Self-associates to form an oligomeric complex.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PLSCR1O151622EBI-357061,EBI-740019

Protein-protein interaction databases

BioGridi115624. 38 interactions.
IntActiQ92734. 21 interactions.
MINTiMINT-1156489.
STRINGi9606.ENSP00000240851.

Structurei

3D structure databases

ProteinModelPortaliQ92734.
SMRiQ92734. Positions 9-89.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili97 – 12428 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG85275.
HOGENOMiHOG000132915.
HOVERGENiHBG009087.
InParanoidiQ92734.
KOiK09292.
OMAiIQYSAGY.
OrthoDBiEOG7TXKJH.
PhylomeDBiQ92734.
TreeFamiTF318743.

Family and domain databases

InterProiIPR000270. OPR_PB1.
[Graphical view]
PfamiPF00564. PB1. 1 hit.
[Graphical view]
SMARTiSM00666. PB1. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q92734-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MNGQLDLSGK LIIKAQLGED IRRIPIHNED ITYDELVLMM QRVFRGKLLS    50
NDEVTIKYKD EDGDLITIFD SSDLSFAIQC SRILKLTLFV NGQPRPLESS 100
QVKYLRRELI ELRNKVNRLL DSLEPPGEPG PSTNIPENDT VDGREEKSAS 150
DSSGKQSTQV MAASMSAFDP LKNQDEINKN VMSAFGLTDD QVSGPPSAPA 200
EDRSGTPDSI ASSSSAAHPP GVQPQQPPYT GAQTQAGQIE GQMYQQYQQQ 250
AGYGAQQPQA PPQQPQQYGI QYSASYSQQT GPQQPQQFQG YGQQPTSQAP 300
APAFSGQPQQ LPAQPPQQYQ ASNYPAQTYT AQTSQPTNYT VAPASQPGMA 350
PSQPGAYQPR PGFTSLPGST MTPPPSGPNP YARNRPPFGQ GYTQPGPGYR 400
Length:400
Mass (Da):43,448
Last modified:February 10, 2009 - v2
Checksum:iD8A559D0F7314D1F
GO
Isoform 2 (identifier: Q92734-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     237-240: Missing.

Note: No experimental confirmation available.

Show »
Length:396
Mass (Da):43,020
Checksum:iE4FF3B134949F61C
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti43 – 431V → F.
Corresponds to variant rs15245 [ dbSNP | Ensembl ].
VAR_059731
Natural varianti106 – 1061R → C in SPG57; defective self-assembly into an oligomeric complex. 1 Publication
VAR_070986
Natural varianti149 – 1491A → S in a colorectal cancer sample; somatic mutation. 1 Publication
VAR_035668
Natural varianti211 – 2111A → V.
Corresponds to variant rs430945 [ dbSNP | Ensembl ].
VAR_054322
Natural varianti285 – 2851P → L in HMSNP; results in mislocalization and TARDBP-inclusion-body formation in cultured cells. 1 Publication
VAR_068917
Natural varianti364 – 3641T → P.
Corresponds to variant rs6772054 [ dbSNP | Ensembl ].
VAR_054323

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei237 – 2404Missing in isoform 2.
VSP_047131

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti13 – 131I → V in CAA69264. 1 Publication
Sequence conflicti13 – 131I → V in CAA59936. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07968 mRNA. Translation: CAA69264.1.
AK093456 mRNA. Translation: BAG52721.1.
BT007428 mRNA. Translation: AAP36096.1.
CR456781 mRNA. Translation: CAG33062.1.
AC068763 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79813.1.
CH471052 Genomic DNA. Translation: EAW79814.1.
CH471052 Genomic DNA. Translation: EAW79815.1.
CH471052 Genomic DNA. Translation: EAW79816.1.
CH471052 Genomic DNA. Translation: EAW79817.1.
BC001483 mRNA. Translation: AAH01483.1.
BC009241 mRNA. Translation: AAH09241.1.
BC023599 mRNA. Translation: AAH23599.1.
X85960 mRNA. Translation: CAA59936.1. Different termination.
CCDSiCCDS2939.1. [Q92734-1]
CCDS56266.1. [Q92734-2]
RefSeqiNP_001007566.1. NM_001007565.2. [Q92734-1]
NP_001182407.1. NM_001195478.1. [Q92734-1]
NP_001182408.1. NM_001195479.1. [Q92734-2]
NP_006061.2. NM_006070.5. [Q92734-1]
XP_005247123.1. XM_005247066.1. [Q92734-2]
XP_006713535.1. XM_006713472.1. [Q92734-1]
XP_006713536.1. XM_006713473.1. [Q92734-1]
UniGeneiHs.518123.

Genome annotation databases

EnsembliENST00000240851; ENSP00000240851; ENSG00000114354. [Q92734-1]
ENST00000418917; ENSP00000397182; ENSG00000114354. [Q92734-2]
ENST00000476228; ENSP00000417952; ENSG00000114354. [Q92734-2]
ENST00000490574; ENSP00000419960; ENSG00000114354. [Q92734-1]
GeneIDi10342.
KEGGihsa:10342.
UCSCiuc003due.3. human. [Q92734-1]
uc003dug.3. human.

Polymorphism databases

DMDMi223634676.

Keywords - Coding sequence diversityi

Alternative splicing, Chromosomal rearrangement, Polymorphism

Cross-referencesi

Web resourcesi

Atlas of Genetics and Cytogenetics in Oncology and Haematology

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
Y07968 mRNA. Translation: CAA69264.1 .
AK093456 mRNA. Translation: BAG52721.1 .
BT007428 mRNA. Translation: AAP36096.1 .
CR456781 mRNA. Translation: CAG33062.1 .
AC068763 Genomic DNA. No translation available.
CH471052 Genomic DNA. Translation: EAW79813.1 .
CH471052 Genomic DNA. Translation: EAW79814.1 .
CH471052 Genomic DNA. Translation: EAW79815.1 .
CH471052 Genomic DNA. Translation: EAW79816.1 .
CH471052 Genomic DNA. Translation: EAW79817.1 .
BC001483 mRNA. Translation: AAH01483.1 .
BC009241 mRNA. Translation: AAH09241.1 .
BC023599 mRNA. Translation: AAH23599.1 .
X85960 mRNA. Translation: CAA59936.1 . Different termination.
CCDSi CCDS2939.1. [Q92734-1 ]
CCDS56266.1. [Q92734-2 ]
RefSeqi NP_001007566.1. NM_001007565.2. [Q92734-1 ]
NP_001182407.1. NM_001195478.1. [Q92734-1 ]
NP_001182408.1. NM_001195479.1. [Q92734-2 ]
NP_006061.2. NM_006070.5. [Q92734-1 ]
XP_005247123.1. XM_005247066.1. [Q92734-2 ]
XP_006713535.1. XM_006713472.1. [Q92734-1 ]
XP_006713536.1. XM_006713473.1. [Q92734-1 ]
UniGenei Hs.518123.

3D structure databases

ProteinModelPortali Q92734.
SMRi Q92734. Positions 9-89.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 115624. 38 interactions.
IntActi Q92734. 21 interactions.
MINTi MINT-1156489.
STRINGi 9606.ENSP00000240851.

PTM databases

PhosphoSitei Q92734.

Polymorphism databases

DMDMi 223634676.

Proteomic databases

MaxQBi Q92734.
PaxDbi Q92734.
PRIDEi Q92734.

Protocols and materials databases

DNASUi 10342.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENST00000240851 ; ENSP00000240851 ; ENSG00000114354 . [Q92734-1 ]
ENST00000418917 ; ENSP00000397182 ; ENSG00000114354 . [Q92734-2 ]
ENST00000476228 ; ENSP00000417952 ; ENSG00000114354 . [Q92734-2 ]
ENST00000490574 ; ENSP00000419960 ; ENSG00000114354 . [Q92734-1 ]
GeneIDi 10342.
KEGGi hsa:10342.
UCSCi uc003due.3. human. [Q92734-1 ]
uc003dug.3. human.

Organism-specific databases

CTDi 10342.
GeneCardsi GC03P100428.
H-InvDB HIX0003505.
HGNCi HGNC:11758. TFG.
HPAi HPA019473.
HPA052206.
MIMi 188550. phenotype.
602498. gene.
604484. phenotype.
615658. phenotype.
neXtProti NX_Q92734.
Orphaneti 209916. Extraskeletal myxoid chondrosarcoma.
90117. Hereditary motor and sensory neuropathy, Okinawa type.
146. Papillary or follicular thyroid carcinoma.
320406. Spastic paraplegia-optic atrophy-neuropathy syndrome.
PharmGKBi PA36473.
GenAtlasi Search...

Phylogenomic databases

eggNOGi NOG85275.
HOGENOMi HOG000132915.
HOVERGENi HBG009087.
InParanoidi Q92734.
KOi K09292.
OMAi IQYSAGY.
OrthoDBi EOG7TXKJH.
PhylomeDBi Q92734.
TreeFami TF318743.

Enzyme and pathway databases

SignaLinki Q92734.

Miscellaneous databases

ChiTaRSi TFG. human.
GeneWikii TFG_(gene).
GenomeRNAii 10342.
NextBioi 18907.
PROi Q92734.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q92734.
Bgeei Q92734.
CleanExi HS_TFG.
Genevestigatori Q92734.

Family and domain databases

InterProi IPR000270. OPR_PB1.
[Graphical view ]
Pfami PF00564. PB1. 1 hit.
[Graphical view ]
SMARTi SM00666. PB1. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Characterization and chromosomal mapping of the human TFG gene involved in thyroid carcinoma."
    Mencinger M., Panagopoluos I., Andreasson P., Lassen C., Mitelman F., Aman P.
    Genomics 41:327-331(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Tissue: Pancreas.
  2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Testis.
  3. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
    Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
    Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "The DNA sequence, annotation and analysis of human chromosome 3."
    Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
    , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
    Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain, Placenta and Uterus.
  8. "The DNA rearrangement that generates the TRK-T3 oncogene involves a novel gene on chromosome 3 whose product has a potential coiled-coil domain."
    Greco A., Mariani C., Miranda C., Lupas A., Pagliardini S., Pomati M., Pierotti M.A.
    Mol. Cell. Biol. 15:6118-6127(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1-193, CHROMOSOMAL TRANSLOCATION WITH NTRK1.
  9. Bienvenut W.V., Calvo F., Kolch W.
    Submitted (FEB-2008) to UniProtKB
    Cited for: PROTEIN SEQUENCE OF 1-10; 15-22; 24-42 AND 48-57, ACETYLATION AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY.
    Tissue: Cervix carcinoma.
  10. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  11. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  12. "Quantitative phosphoproteomic analysis of T cell receptor signaling reveals system-wide modulation of protein-protein interactions."
    Mayya V., Lundgren D.H., Hwang S.-I., Rezaul K., Wu L., Eng J.K., Rodionov V., Han D.K.
    Sci. Signal. 2:RA46-RA46(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-197, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Leukemic T-cell.
  13. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  14. "Comparative large-scale characterisation of plant vs. mammal proteins reveals similar and idiosyncratic N-alpha acetylation features."
    Bienvenut W.V., Sumpton D., Martinez A., Lilla S., Espagne C., Meinnel T., Giglione C.
    Mol. Cell. Proteomics 11:M111.015131-M111.015131(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  15. Cited for: FUNCTION, SUBUNIT, VARIANT SPG57 CYS-106, CHARACTERIZATION OF VARIANT SPG57 CYS-106.
  16. Cited for: VARIANT [LARGE SCALE ANALYSIS] SER-149.
  17. Cited for: VARIANT HMSNP LEU-285, CHARACTERIZATION OF VARIANT HMSNP LEU-285.

Entry informationi

Entry nameiTFG_HUMAN
AccessioniPrimary (citable) accession number: Q92734
Secondary accession number(s): D3DN49
, G5E9V1, Q15656, Q969I2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 2, 2004
Last sequence update: February 10, 2009
Last modified: September 3, 2014
This is version 125 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Direct protein sequencing, Reference proteome

Documents

  1. Human chromosome 3
    Human chromosome 3: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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