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Protein

Proline-rich protein PRCC

Gene

PRCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

May regulate cell cycle progression through interaction with MAD2L2.1 Publication

GO - Biological processi

  • mitotic cell cycle checkpoint Source: UniProtKB
  • mRNA splicing, via spliceosome Source: Reactome

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-HSA-72163 mRNA Splicing - Major Pathway
SIGNORiQ92733

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein PRCC
Alternative name(s):
Papillary renal cell carcinoma translocation-associated gene protein
Gene namesi
Name:PRCC
Synonyms:TPRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143294.14
HGNCiHGNC:9343 PRCC
MIMi179755 gene
neXtProtiNX_Q92733

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.2 Publications

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi5546
MalaCardsiPRCC
OpenTargetsiENSG00000143294
Orphaneti319308 Translocation renal cell carcinoma
PharmGKBiPA33704

Polymorphism and mutation databases

BioMutaiPRCC
DMDMi2498802

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585681 – 491Proline-rich protein PRCCAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei239PhosphothreonineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92733
MaxQBiQ92733
PaxDbiQ92733
PeptideAtlasiQ92733
PRIDEiQ92733

PTM databases

iPTMnetiQ92733
PhosphoSitePlusiQ92733

Expressioni

Tissue specificityi

Ubiquitous in fetal and adult tissues.

Gene expression databases

BgeeiENSG00000143294
CleanExiHS_PRCC
ExpressionAtlasiQ92733 baseline and differential
GenevisibleiQ92733 HS

Organism-specific databases

HPAiCAB017151
HPA019463
HPA019481

Interactioni

Subunit structurei

Interacts with MAD2L2; the interaction is direct.1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
HOMER3Q9NSC53EBI-4397741,EBI-748420

Protein-protein interaction databases

BioGridi111537, 49 interactors
IntActiQ92733, 23 interactors
MINTiQ92733
STRINGi9606.ENSP00000271526

Structurei

3D structure databases

ProteinModelPortaliQ92733
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 100Mediates interaction with MAD2L21 PublicationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Glu8
Compositional biasi52 – 55Poly-Pro4
Compositional biasi79 – 84Poly-Pro6
Compositional biasi91 – 94Poly-Pro4
Compositional biasi235 – 239Poly-Thr5

Phylogenomic databases

eggNOGiKOG3903 Eukaryota
ENOG4111HM1 LUCA
GeneTreeiENSGT00390000009042
HOGENOMiHOG000247067
HOVERGENiHBG002845
InParanoidiQ92733
KOiK13105
OMAiGAPWVPK
OrthoDBiEOG091G0P65
PhylomeDBiQ92733
TreeFamiTF318780

Family and domain databases

InterProiView protein in InterPro
IPR018800 PRCC
PANTHERiPTHR13621 PTHR13621, 1 hit
PfamiView protein in Pfam
PF10253 PRCC, 1 hit

Sequencei

Sequence statusi: Complete.

Q92733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVAYASSD ESEPDEAEPE PEEEEAVAPT SGPALGGLFA SLPAPKGPAL
60 70 80 90 100
LPPPPQMLAP AFPPPLLLPP PTGDPRLQPP PPLPFGLGGF PPPPGVSPAE
110 120 130 140 150
AAGVGEGLGL GLPSPRGPGL NLPPPIGGAG PPLGLPKPKK RKEPVKIAAP
160 170 180 190 200
ELHKGDSDSE EDEPTKKKTI LQGSSEGTGL SALLPQPKNL TVKETNRLLL
210 220 230 240 250
PHAFSRKPSD GSPDTKPSRL ASKTKTSSLA PVVGTTTTTP SPSAIKAAAK
260 270 280 290 300
SAALQVTKQI TQEEDDSDEE VAPENFFSLP EKAEPPGVEP YPYPIPTVPE
310 320 330 340 350
ELPPGTEPEP AFQDDAANAP LEFKMAAGSS GAPWMPKPGD DYSYNQFSTY
360 370 380 390 400
GDANAAGAYY QDYYSGGYYP AQDPALVPPQ EIAPDASFID DEAFKRLQGK
410 420 430 440 450
RNRGREEINF VEIKGDDQLS GAQQWMTKSL TEEKTMKSFS KKKGEQPTGQ
460 470 480 490
QRRKHQITYL IHQAKERELE LKNTWSENKL SRRQTQAKYG F
Length:491
Mass (Da):52,418
Last modified:February 1, 1997 - v1
Checksum:iF99CFD9D42725D57
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024341136P → S1 PublicationCorresponds to variant dbSNP:rs11264542Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97124 mRNA Translation: CAA65791.1
X99720 Genomic DNA Translation: CAA68060.1
AK289872 mRNA Translation: BAF82561.1
AL590666 Genomic DNA No translation available.
CH471121 Genomic DNA Translation: EAW52909.1
BC004913 mRNA Translation: AAH04913.1
CCDSiCCDS1157.1
RefSeqiNP_005964.3, NM_005973.4
UniGeneiHs.516948

Genome annotation databases

EnsembliENST00000271526; ENSP00000271526; ENSG00000143294
GeneIDi5546
KEGGihsa:5546
UCSCiuc001fqa.4 human

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRCC_HUMAN
AccessioniPrimary (citable) accession number: Q92733
Secondary accession number(s): A8K1F7
, O00665, O00724, Q5SZ06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 157 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

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