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Protein

Proline-rich protein PRCC

Gene

PRCC

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May regulate cell cycle progression through interaction with MAD2L2.1 Publication

GO - Biological processi

  • mitotic cell cycle checkpoint Source: UniProtKB
  • mRNA splicing, via spliceosome Source: Reactome

Keywordsi

Biological processCell cycle

Enzyme and pathway databases

ReactomeiR-HSA-72163. mRNA Splicing - Major Pathway.
SIGNORiQ92733.

Names & Taxonomyi

Protein namesi
Recommended name:
Proline-rich protein PRCC
Alternative name(s):
Papillary renal cell carcinoma translocation-associated gene protein
Gene namesi
Name:PRCC
Synonyms:TPRC
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 1

Organism-specific databases

EuPathDBiHostDB:ENSG00000143294.14.
HGNCiHGNC:9343. PRCC.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

Pathology & Biotechi

Involvement in diseasei

A chromosomal aberration involving PRCC is found in patients with papillary renal cell carcinoma. Translocation t(X;1)(p11.2;q21.2) with TFE3.2 Publications

Keywords - Diseasei

Proto-oncogene

Organism-specific databases

DisGeNETi5546.
MalaCardsiPRCC.
OpenTargetsiENSG00000143294.
Orphaneti319308. Translocation renal cell carcinoma.
PharmGKBiPA33704.

Polymorphism and mutation databases

BioMutaiPRCC.
DMDMi2498802.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000585681 – 491Proline-rich protein PRCCAdd BLAST491

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei97PhosphoserineCombined sources1
Modified residuei114PhosphoserineCombined sources1
Modified residuei157PhosphoserineCombined sources1
Modified residuei159PhosphoserineCombined sources1
Modified residuei212PhosphoserineCombined sources1
Modified residuei218PhosphoserineCombined sources1
Modified residuei239PhosphothreonineCombined sources1
Modified residuei241PhosphoserineCombined sources1
Modified residuei267PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92733.
MaxQBiQ92733.
PaxDbiQ92733.
PeptideAtlasiQ92733.
PRIDEiQ92733.

PTM databases

iPTMnetiQ92733.
PhosphoSitePlusiQ92733.

Expressioni

Tissue specificityi

Ubiquitous in fetal and adult tissues.

Gene expression databases

BgeeiENSG00000143294.
CleanExiHS_PRCC.
ExpressionAtlasiQ92733. baseline and differential.
GenevisibleiQ92733. HS.

Organism-specific databases

HPAiCAB017151.
HPA019463.
HPA019481.

Interactioni

Subunit structurei

Interacts with MAD2L2; the interaction is direct.1 Publication

Protein-protein interaction databases

BioGridi111537. 48 interactors.
IntActiQ92733. 22 interactors.
MINTiMINT-4536336.
STRINGi9606.ENSP00000271526.

Structurei

3D structure databases

ProteinModelPortaliQ92733.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 100Mediates interaction with MAD2L21 PublicationAdd BLAST100

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi18 – 25Poly-Glu8
Compositional biasi52 – 55Poly-Pro4
Compositional biasi79 – 84Poly-Pro6
Compositional biasi91 – 94Poly-Pro4
Compositional biasi235 – 239Poly-Thr5

Phylogenomic databases

eggNOGiKOG3903. Eukaryota.
ENOG4111HM1. LUCA.
GeneTreeiENSGT00390000009042.
HOGENOMiHOG000247067.
HOVERGENiHBG002845.
InParanoidiQ92733.
KOiK13105.
OMAiGAPWVPK.
OrthoDBiEOG091G0P65.
PhylomeDBiQ92733.
TreeFamiTF318780.

Family and domain databases

InterProiView protein in InterPro
IPR018800. PRCC.
PANTHERiPTHR13621. PTHR13621. 1 hit.
PfamiView protein in Pfam
PF10253. PRCC. 1 hit.

Sequencei

Sequence statusi: Complete.

Q92733-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MSLVAYASSD ESEPDEAEPE PEEEEAVAPT SGPALGGLFA SLPAPKGPAL
60 70 80 90 100
LPPPPQMLAP AFPPPLLLPP PTGDPRLQPP PPLPFGLGGF PPPPGVSPAE
110 120 130 140 150
AAGVGEGLGL GLPSPRGPGL NLPPPIGGAG PPLGLPKPKK RKEPVKIAAP
160 170 180 190 200
ELHKGDSDSE EDEPTKKKTI LQGSSEGTGL SALLPQPKNL TVKETNRLLL
210 220 230 240 250
PHAFSRKPSD GSPDTKPSRL ASKTKTSSLA PVVGTTTTTP SPSAIKAAAK
260 270 280 290 300
SAALQVTKQI TQEEDDSDEE VAPENFFSLP EKAEPPGVEP YPYPIPTVPE
310 320 330 340 350
ELPPGTEPEP AFQDDAANAP LEFKMAAGSS GAPWMPKPGD DYSYNQFSTY
360 370 380 390 400
GDANAAGAYY QDYYSGGYYP AQDPALVPPQ EIAPDASFID DEAFKRLQGK
410 420 430 440 450
RNRGREEINF VEIKGDDQLS GAQQWMTKSL TEEKTMKSFS KKKGEQPTGQ
460 470 480 490
QRRKHQITYL IHQAKERELE LKNTWSENKL SRRQTQAKYG F
Length:491
Mass (Da):52,418
Last modified:February 1, 1997 - v1
Checksum:iF99CFD9D42725D57
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_024341136P → S1 PublicationCorresponds to variant dbSNP:rs11264542Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97124 mRNA. Translation: CAA65791.1.
X99720 Genomic DNA. Translation: CAA68060.1.
AK289872 mRNA. Translation: BAF82561.1.
AL590666 Genomic DNA. No translation available.
CH471121 Genomic DNA. Translation: EAW52909.1.
BC004913 mRNA. Translation: AAH04913.1.
CCDSiCCDS1157.1.
RefSeqiNP_005964.3. NM_005973.4.
UniGeneiHs.516948.

Genome annotation databases

EnsembliENST00000271526; ENSP00000271526; ENSG00000143294.
GeneIDi5546.
KEGGihsa:5546.
UCSCiuc001fqa.4. human.

Keywords - Coding sequence diversityi

Chromosomal rearrangement, Polymorphism

Similar proteinsi

Entry informationi

Entry nameiPRCC_HUMAN
AccessioniPrimary (citable) accession number: Q92733
Secondary accession number(s): A8K1F7
, O00665, O00724, Q5SZ06
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: November 22, 2017
This is version 153 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 1
    Human chromosome 1: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot