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Protein

Rho-related GTP-binding protein Rho6

Gene

RND1

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Lacks intrinsic GTPase activity. Has a low affinity for GDP, and constitutively binds GTP. Controls rearrangements of the actin cytoskeleton. Induces the Rac-dependent neuritic process formation in part by disruption of the cortical actin filaments. Causes the formation of many neuritic processes from the cell body with disruption of the cortical actin filaments.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 28GTPCombined sources1 Publication6
Nucleotide bindingi38 – 45GTPCombined sources1 Publication8
Nucleotide bindingi67 – 71GTPCombined sources1 Publication5
Nucleotide bindingi125 – 128GTPCombined sources1 Publication4
Nucleotide bindingi169 – 170GTPCombined sources1 Publication2

GO - Molecular functioni

  • GTPase activity Source: UniProtKB
  • GTP binding Source: UniProtKB-KW
  • signaling receptor binding Source: UniProtKB

GO - Biological processi

  • actin filament organization Source: UniProtKB
  • negative regulation of cell adhesion Source: UniProtKB
  • neuron remodeling Source: UniProtKB
  • small GTPase mediated signal transduction Source: InterPro

Keywordsi

LigandGTP-binding, Nucleotide-binding

Enzyme and pathway databases

ReactomeiR-HSA-399955 SEMA3A-Plexin repulsion signaling by inhibiting Integrin adhesion
R-HSA-416550 Sema4D mediated inhibition of cell attachment and migration
R-HSA-416572 Sema4D induced cell migration and growth-cone collapse
SignaLinkiQ92730
SIGNORiQ92730

Names & Taxonomyi

Protein namesi
Recommended name:
Rho-related GTP-binding protein Rho6
Alternative name(s):
Rho family GTPase 1
Rnd1
Gene namesi
Name:RND1
Synonyms:RHO6
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 12

Organism-specific databases

EuPathDBiHostDB:ENSG00000172602.9
HGNCiHGNC:18314 RND1
MIMi609038 gene
neXtProtiNX_Q92730

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Cytoskeleton, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi27T → N: Impairs interaction with UBXD5. 1 Publication1
Mutagenesisi45T → A: Abolishes interaction with UBXD5. 1 Publication1

Organism-specific databases

DisGeNETi27289
OpenTargetsiENSG00000172602
PharmGKBiPA134972408

Polymorphism and mutation databases

BioMutaiRND1
DMDMi2500182

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001988741 – 229Rho-related GTP-binding protein Rho6Add BLAST229
PropeptideiPRO_0000281226230 – 232Removed in mature formBy similarity3

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei229Cysteine methyl esterBy similarity1
Lipidationi229S-geranylgeranyl cysteineBy similarity1

Keywords - PTMi

Lipoprotein, Methylation, Prenylation

Proteomic databases

PaxDbiQ92730
PRIDEiQ92730

PTM databases

iPTMnetiQ92730
PhosphoSitePlusiQ92730

Expressioni

Tissue specificityi

Mostly expressed in brain and liver.

Gene expression databases

BgeeiENSG00000172602
CleanExiHS_RND1
ExpressionAtlasiQ92730 baseline and differential
GenevisibleiQ92730 HS

Organism-specific databases

HPAiHPA077800

Interactioni

Subunit structurei

Binds GRB7 and PLXNB1. Interacts with UBXD5. Interacts with PLXNA2.5 Publications

Binary interactionsi

Show more details

GO - Molecular functioni

  • signaling receptor binding Source: UniProtKB

Protein-protein interaction databases

BioGridi118113, 13 interactors
DIPiDIP-36741N
IntActiQ92730, 7 interactors
MINTiQ92730
STRINGi9606.ENSP00000308461

Structurei

Secondary structure

1232
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Beta strandi10 – 12Combined sources3
Beta strandi14 – 19Combined sources6
Helixi26 – 35Combined sources10
Beta strandi46 – 55Combined sources10
Beta strandi60 – 68Combined sources9
Helixi72 – 74Combined sources3
Turni75 – 77Combined sources3
Helixi78 – 81Combined sources4
Beta strandi86 – 93Combined sources8
Helixi98 – 104Combined sources7
Helixi106 – 114Combined sources9
Beta strandi118 – 125Combined sources8
Helixi127 – 131Combined sources5
Helixi133 – 141Combined sources9
Helixi149 – 159Combined sources11
Beta strandi162 – 166Combined sources5
Turni169 – 171Combined sources3
Helixi173 – 188Combined sources16

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
2CLSX-ray2.31A/B5-200[»]
2REXX-ray2.30B/D5-200[»]
3Q3JX-ray1.97B5-200[»]
ProteinModelPortaliQ92730
SMRiQ92730
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92730

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi42 – 50Effector regionSequence analysis9

Sequence similaritiesi

Belongs to the small GTPase superfamily. Rho family.Curated

Phylogenomic databases

eggNOGiKOG0393 Eukaryota
COG1100 LUCA
GeneTreeiENSGT00760000119020
HOGENOMiHOG000233974
HOVERGENiHBG009351
InParanoidiQ92730
KOiK07531
OMAiHEQGSAM
OrthoDBiEOG091G0M4M
PhylomeDBiQ92730
TreeFamiTF330887

Family and domain databases

InterProiView protein in InterPro
IPR027417 P-loop_NTPase
IPR005225 Small_GTP-bd_dom
IPR001806 Small_GTPase
IPR003578 Small_GTPase_Rho
PfamiView protein in Pfam
PF00071 Ras, 1 hit
SUPFAMiSSF52540 SSF52540, 1 hit
TIGRFAMsiTIGR00231 small_GTP, 1 hit
PROSITEiView protein in PROSITE
PS51420 RHO, 1 hit

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q92730-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKERRAPQPV VARCKLVLVG DVQCGKTAML QVLAKDCYPE TYVPTVFENY
60 70 80 90 100
TACLETEEQR VELSLWDTSG SPYYDNVRPL CYSDSDAVLL CFDISRPETV
110 120 130 140 150
DSALKKWRTE ILDYCPSTRV LLIGCKTDLR TDLSTLMELS HQKQAPISYE
160 170 180 190 200
QGCAIAKQLG AEIYLEGSAF TSEKSIHSIF RTASMLCLNK PSPLPQKSPV
210 220 230
RSLSKRLLHL PSRSELISST FKKEKAKSCS IM
Length:232
Mass (Da):26,056
Last modified:February 1, 1997 - v1
Checksum:i9FD56ACB878FBCCA
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_02018844P → R. Corresponds to variant dbSNP:rs2270577Ensembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y07923 mRNA Translation: CAA69228.1
AB040147 mRNA Translation: BAB17851.1
AF498967 mRNA Translation: AAM21114.1
AK292762 mRNA Translation: BAF85451.1
CH471111 Genomic DNA Translation: EAW58019.1
BC026356 mRNA Translation: AAH26356.1
CCDSiCCDS8771.1
RefSeqiNP_055285.1, NM_014470.3
UniGeneiHs.124940

Genome annotation databases

EnsembliENST00000309739; ENSP00000308461; ENSG00000172602
GeneIDi27289
KEGGihsa:27289
UCSCiuc001rsn.4 human

Keywords - Coding sequence diversityi

Polymorphism

Similar proteinsi

Entry informationi

Entry nameiRND1_HUMAN
AccessioniPrimary (citable) accession number: Q92730
Secondary accession number(s): A8K9P7
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: May 23, 2018
This is version 172 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

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