##gff-version 3 Q92729 UniProtKB Signal peptide 1 18 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Chain 19 1446 . . . ID=PRO_0000371658;Note=Receptor-type tyrosine-protein phosphatase U Q92729 UniProtKB Topological domain 19 749 . . . Note=Extracellular;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Transmembrane 750 770 . . . Note=Helical;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Topological domain 771 1446 . . . Note=Cytoplasmic;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Domain 25 188 . . . Note=MAM;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00128 Q92729 UniProtKB Domain 190 275 . . . Note=Ig-like C2-type Q92729 UniProtKB Domain 288 383 . . . Note=Fibronectin type-III 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 Q92729 UniProtKB Domain 386 484 . . . Note=Fibronectin type-III 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 Q92729 UniProtKB Domain 485 591 . . . Note=Fibronectin type-III 3;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 Q92729 UniProtKB Domain 592 674 . . . Note=Fibronectin type-III 4;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00316 Q92729 UniProtKB Domain 888 1144 . . . Note=Tyrosine-protein phosphatase 1;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160 Q92729 UniProtKB Domain 1176 1439 . . . Note=Tyrosine-protein phosphatase 2;Ontology_term=ECO:0000255;evidence=ECO:0000255|PROSITE-ProRule:PRU00160 Q92729 UniProtKB Region 771 887 . . . Note=Mediates interaction with CTNNB1;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92729 UniProtKB Region 833 861 . . . Note=Disordered;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92729 UniProtKB Compositional bias 833 847 . . . Note=Polar residues;Ontology_term=ECO:0000256;evidence=ECO:0000256|SAM:MobiDB-lite Q92729 UniProtKB Active site 1085 1085 . . . Note=Phosphocysteine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92729 UniProtKB Active site 1380 1380 . . . Note=Phosphocysteine intermediate;Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92729 UniProtKB Binding site 1053 1053 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Binding site 1085 1091 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92729 UniProtKB Binding site 1129 1129 . . . Ontology_term=ECO:0000250;evidence=ECO:0000250 Q92729 UniProtKB Modified residue 848 848 . . . Note=Phosphoserine;Ontology_term=ECO:0007744;evidence=ECO:0007744|PubMed:19690332;Dbxref=PMID:19690332 Q92729 UniProtKB Modified residue 853 853 . . . Note=Phosphoserine;Ontology_term=ECO:0007744,ECO:0007744;evidence=ECO:0007744|PubMed:19690332,ECO:0007744|PubMed:23186163;Dbxref=PMID:19690332,PMID:23186163 Q92729 UniProtKB Modified residue 863 863 . . . Note=Phosphoserine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B1AUH1 Q92729 UniProtKB Modified residue 865 865 . . . Note=Phosphotyrosine;Ontology_term=ECO:0000250;evidence=ECO:0000250|UniProtKB:B1AUH1 Q92729 UniProtKB Glycosylation 75 75 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Glycosylation 410 410 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Glycosylation 685 685 . . . Note=N-linked (GlcNAc...) asparagine;Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Disulfide bond 210 264 . . . Ontology_term=ECO:0000255;evidence=ECO:0000255 Q92729 UniProtKB Alternative sequence 774 783 . . . ID=VSP_037082;Note=In isoform 2%2C isoform 3 and isoform 4. Missing;Ontology_term=ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303,ECO:0000303;evidence=ECO:0000303|PubMed:15489334,ECO:0000303|PubMed:8700514,ECO:0000303|PubMed:9070223,ECO:0000303|PubMed:9434160,ECO:0000303|Ref.9;Dbxref=PMID:15489334,PMID:8700514,PMID:9070223,PMID:9434160 Q92729 UniProtKB Alternative sequence 950 950 . . . ID=VSP_037083;Note=In isoform 4. D->DIRINRE;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9434160;Dbxref=PMID:9434160 Q92729 UniProtKB Alternative sequence 993 995 . . . ID=VSP_037084;Note=In isoform 3. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:15489334;Dbxref=PMID:15489334 Q92729 UniProtKB Alternative sequence 1329 1330 . . . ID=VSP_037085;Note=In isoform 4. Missing;Ontology_term=ECO:0000303;evidence=ECO:0000303|PubMed:9434160;Dbxref=PMID:9434160 Q92729 UniProtKB Natural variant 60 60 . . . ID=VAR_055075;Note=T->N;Dbxref=dbSNP:rs35332573 Q92729 UniProtKB Natural variant 471 471 . . . ID=VAR_055076;Note=R->L;Dbxref=dbSNP:rs35745442 Q92729 UniProtKB Natural variant 830 830 . . . ID=VAR_035650;Note=In a colorectal cancer sample%3B somatic mutation. H->Y;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=PMID:16959974 Q92729 UniProtKB Natural variant 835 835 . . . ID=VAR_035651;Note=In a colorectal cancer sample%3B somatic mutation. R->W;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs558954146,PMID:16959974 Q92729 UniProtKB Natural variant 856 856 . . . ID=VAR_035652;Note=In a colorectal cancer sample%3B somatic mutation. R->C;Ontology_term=ECO:0000269;evidence=ECO:0000269|PubMed:16959974;Dbxref=dbSNP:rs763868325,PMID:16959974 Q92729 UniProtKB Natural variant 940 940 . . . ID=VAR_055077;Note=N->S;Dbxref=dbSNP:rs2235937 Q92729 UniProtKB Mutagenesis 1085 1085 . . . Note=Loss of phosphatase activity toward CTNNB1. Loss of the inhibitory effect on CTNNB1 transcriptional activity without effect on interaction with CTNNB1%3B when associated with S-1380. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12501215,ECO:0000269|PubMed:16574648;Dbxref=PMID:12501215,PMID:16574648 Q92729 UniProtKB Mutagenesis 1380 1380 . . . Note=No effect on phosphatase activity toward CTNNB1. Loss of the inhibitory effect on CTNNB1 transcriptional activity without effect on interaction with CTNNB1%3B when associated with S-1085. C->S;Ontology_term=ECO:0000269,ECO:0000269;evidence=ECO:0000269|PubMed:12501215,ECO:0000269|PubMed:16574648;Dbxref=PMID:12501215,PMID:16574648 Q92729 UniProtKB Sequence conflict 359 360 . . . Note=LT->S;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 401 401 . . . Note=T->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 715 715 . . . Note=E->D;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 840 841 . . . Note=SG->GW;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 1215 1215 . . . Note=P->A;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 1245 1245 . . . Note=A->R;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 1399 1399 . . . Note=M->I;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Sequence conflict 1436 1436 . . . Note=A->V;Ontology_term=ECO:0000305;evidence=ECO:0000305 Q92729 UniProtKB Helix 876 878 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 879 900 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 946 949 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 952 954 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 958 961 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 966 968 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 969 978 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 983 986 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 990 992 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1004 1009 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1012 1021 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1023 1034 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1041 1048 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1053 1056 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 1061 1073 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1081 1084 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 1091 1108 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Beta strand 1109 1111 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 1113 1123 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB Q92729 UniProtKB Helix 1131 1144 . . . Ontology_term=ECO:0007829;evidence=ECO:0007829|PDB:6SUB