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Protein

Geranylgeranyl transferase type-2 subunit alpha

Gene

RABGGTA

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A.1 Publication

Catalytic activityi

Geranylgeranyl diphosphate + protein-cysteine = S-geranylgeranyl-protein + diphosphate.1 Publication

Enzyme regulationi

The enzymatic reaction requires the aid of a Rab escort protein (also called component A), such as CHM.

GO - Molecular functioni

GO - Biological processi

  • cellular protein modification process Source: ProtInc
  • protein geranylgeranylation Source: UniProtKB
  • regulation of apoptotic process Source: Reactome
  • visual perception Source: ProtInc
Complete GO annotation...

Keywords - Molecular functioni

Prenyltransferase, Transferase

Enzyme and pathway databases

BioCyciZFISH:HS02171-MONOMER.
ReactomeiR-HSA-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Names & Taxonomyi

Protein namesi
Recommended name:
Geranylgeranyl transferase type-2 subunit alpha (EC:2.5.1.60)
Alternative name(s):
Geranylgeranyl transferase type II subunit alpha
Rab geranyl-geranyltransferase subunit alpha
Short name:
Rab GG transferase alpha
Short name:
Rab GGTase alpha
Rab geranylgeranyltransferase subunit alpha
Gene namesi
Name:RABGGTA
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome 14

Organism-specific databases

HGNCiHGNC:9795. RABGGTA.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Pathology & Biotechi

Organism-specific databases

OpenTargetsiENSG00000100949.
PharmGKBiPA34156.

Polymorphism and mutation databases

BioMutaiRABGGTA.
DMDMi6093707.

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001197571 – 567Geranylgeranyl transferase type-2 subunit alphaAdd BLAST567

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei98PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ92696.
MaxQBiQ92696.
PaxDbiQ92696.
PeptideAtlasiQ92696.
PRIDEiQ92696.

PTM databases

iPTMnetiQ92696.
PhosphoSitePlusiQ92696.

Expressioni

Gene expression databases

BgeeiENSG00000100949.
CleanExiHS_RABGGTA.
ExpressionAtlasiQ92696. baseline and differential.
GenevisibleiQ92696. HS.

Organism-specific databases

HPAiHPA043488.

Interactioni

Subunit structurei

Heterotrimer composed of RABGGTA, RABGGTB and CHM; within this trimer, RABGGTA and RABGGTB form the catalytic component B, while CHM (component A) mediates peptide substrate binding. The Rab GGTase dimer (RGGT) interacts with CHM (component A) prior to Rab protein binding; the association is stabilized by geranylgeranyl pyrophosphate (GGpp). The CHM:RGGT:Rab complex is destabilized by GGpp.2 Publications

GO - Molecular functioni

Protein-protein interaction databases

BioGridi111813. 27 interactors.
IntActiQ92696. 3 interactors.
STRINGi9606.ENSP00000216840.

Structurei

3D structure databases

ProteinModelPortaliQ92696.
SMRiQ92696.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati44 – 78PFTA 1Add BLAST35
Repeati88 – 122PFTA 2Add BLAST35
Repeati124 – 158PFTA 3Add BLAST35
Repeati159 – 193PFTA 4Add BLAST35
Repeati207 – 241PFTA 5Add BLAST35
Repeati363 – 397PFTA 6Add BLAST35
Repeati442 – 463LRR 1Add BLAST22
Repeati464 – 486LRR 2Add BLAST23
Repeati487 – 508LRR 3Add BLAST22
Repeati509 – 530LRR 4Add BLAST22
Repeati534 – 555LRR 5Add BLAST22

Sequence similaritiesi

Contains 5 LRR (leucine-rich) repeats.Curated
Contains 6 PFTA repeats.PROSITE-ProRule annotation

Keywords - Domaini

Leucine-rich repeat, Repeat

Phylogenomic databases

eggNOGiKOG0529. Eukaryota.
COG5536. LUCA.
GeneTreeiENSGT00550000075121.
HOGENOMiHOG000007845.
HOVERGENiHBG002171.
InParanoidiQ92696.
KOiK14050.
OMAiMRAAYLD.
OrthoDBiEOG091G0L9H.
PhylomeDBiQ92696.
TreeFamiTF315057.

Family and domain databases

Gene3Di2.60.40.1130. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR002088. Prenyl_trans_a.
IPR009087. RabGGT_asu_insert-domain.
IPR032955. RabGGTase_alpha.
[Graphical view]
PANTHERiPTHR11129:SF2. PTHR11129:SF2. 2 hits.
PfamiPF01239. PPTA. 4 hits.
PF07711. RabGGT_insert. 1 hit.
[Graphical view]
ProDomiPD331837. RabGG_trans_A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49594. SSF49594. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
PS51147. PFTA. 6 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q92696-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHGRLKVKTS EEQAEAKRLE REQKLKLYQS ATQAVFQKRQ AGELDESVLE
60 70 80 90 100
LTSQILGANP DFATLWNCRR EVLQQLETQK SPEELAALVK AELGFLESCL
110 120 130 140 150
RVNPKSYGTW HHRCWLLGRL PEPNWTRELE LCARFLEVDE RNFHCWDYRR
160 170 180 190 200
FVATQAAVPP AEELAFTDSL ITRNFSNYSS WHYRSCLLPQ LHPQPDSGPQ
210 220 230 240 250
GRLPEDVLLK ELELVQNAFF TDPNDQSAWF YHRWLLGRAD PQDALRCLHV
260 270 280 290 300
SRDEACLTVS FSRPLLVGSR MEILLLMVDD SPLIVEWRTP DGRNRPSHVW
310 320 330 340 350
LCDLPAASLN DQLPQHTFRV IWTAGDVQKE CVLLKGRQEG WCRDSTTDEQ
360 370 380 390 400
LFRCELSVEK STVLQSELES CKELQELEPE NKWCLLTIIL LMRALDPLLY
410 420 430 440 450
EKETLQYFQT LKAVDPMRAT YLDDLRSKFL LENSVLKMEY AEVRVLHLAH
460 470 480 490 500
KDLTVLCHLE QLLLVTHLDL SHNRLRTLPP ALAALRCLEV LQASDNAIES
510 520 530 540 550
LDGVTNLPRL QELLLCNNRL QQPAVLQPLA SCPRLVLLNL QGNPLCQAVG
560
ILEQLAELLP SVSSVLT
Length:567
Mass (Da):65,072
Last modified:July 15, 1999 - v2
Checksum:iABA1AFFC8A496C5F
GO

Natural variant

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Natural variantiVAR_020406420T → A.1 PublicationCorresponds to variant rs729421dbSNPEnsembl.1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08200 mRNA. Translation: CAA69382.1.
AK291347 mRNA. Translation: BAF84036.1.
AK292613 mRNA. Translation: BAF85302.1.
CH471078 Genomic DNA. Translation: EAW66044.1.
CH471078 Genomic DNA. Translation: EAW66045.1.
BC003093 mRNA. Translation: AAH03093.1.
CCDSiCCDS45088.1.
PIRiJC5538.
RefSeqiNP_004572.3. NM_004581.5.
NP_878256.1. NM_182836.2.
UniGeneiHs.377992.

Genome annotation databases

EnsembliENST00000216840; ENSP00000216840; ENSG00000100949.
ENST00000399409; ENSP00000382341; ENSG00000100949.
GeneIDi5875.
KEGGihsa:5875.
UCSCiuc001wof.5. human.

Keywords - Coding sequence diversityi

Polymorphism

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
Y08200 mRNA. Translation: CAA69382.1.
AK291347 mRNA. Translation: BAF84036.1.
AK292613 mRNA. Translation: BAF85302.1.
CH471078 Genomic DNA. Translation: EAW66044.1.
CH471078 Genomic DNA. Translation: EAW66045.1.
BC003093 mRNA. Translation: AAH03093.1.
CCDSiCCDS45088.1.
PIRiJC5538.
RefSeqiNP_004572.3. NM_004581.5.
NP_878256.1. NM_182836.2.
UniGeneiHs.377992.

3D structure databases

ProteinModelPortaliQ92696.
SMRiQ92696.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111813. 27 interactors.
IntActiQ92696. 3 interactors.
STRINGi9606.ENSP00000216840.

PTM databases

iPTMnetiQ92696.
PhosphoSitePlusiQ92696.

Polymorphism and mutation databases

BioMutaiRABGGTA.
DMDMi6093707.

Proteomic databases

EPDiQ92696.
MaxQBiQ92696.
PaxDbiQ92696.
PeptideAtlasiQ92696.
PRIDEiQ92696.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000216840; ENSP00000216840; ENSG00000100949.
ENST00000399409; ENSP00000382341; ENSG00000100949.
GeneIDi5875.
KEGGihsa:5875.
UCSCiuc001wof.5. human.

Organism-specific databases

CTDi5875.
GeneCardsiRABGGTA.
HGNCiHGNC:9795. RABGGTA.
HPAiHPA043488.
MIMi601905. gene.
neXtProtiNX_Q92696.
OpenTargetsiENSG00000100949.
PharmGKBiPA34156.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiKOG0529. Eukaryota.
COG5536. LUCA.
GeneTreeiENSGT00550000075121.
HOGENOMiHOG000007845.
HOVERGENiHBG002171.
InParanoidiQ92696.
KOiK14050.
OMAiMRAAYLD.
OrthoDBiEOG091G0L9H.
PhylomeDBiQ92696.
TreeFamiTF315057.

Enzyme and pathway databases

BioCyciZFISH:HS02171-MONOMER.
ReactomeiR-HSA-6803205. TP53 regulates transcription of several additional cell death genes whose specific roles in p53-dependent apoptosis remain uncertain.

Miscellaneous databases

GenomeRNAii5875.
PROiQ92696.
SOURCEiSearch...

Gene expression databases

BgeeiENSG00000100949.
CleanExiHS_RABGGTA.
ExpressionAtlasiQ92696. baseline and differential.
GenevisibleiQ92696. HS.

Family and domain databases

Gene3Di2.60.40.1130. 1 hit.
3.80.10.10. 1 hit.
InterProiIPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR002088. Prenyl_trans_a.
IPR009087. RabGGT_asu_insert-domain.
IPR032955. RabGGTase_alpha.
[Graphical view]
PANTHERiPTHR11129:SF2. PTHR11129:SF2. 2 hits.
PfamiPF01239. PPTA. 4 hits.
PF07711. RabGGT_insert. 1 hit.
[Graphical view]
ProDomiPD331837. RabGG_trans_A. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SUPFAMiSSF49594. SSF49594. 1 hit.
SSF52058. SSF52058. 1 hit.
PROSITEiPS51450. LRR. 5 hits.
PS51147. PFTA. 6 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiPGTA_HUMAN
AccessioniPrimary (citable) accession number: Q92696
Secondary accession number(s): A8K5N2, D3DS69
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: July 15, 1999
Last modified: November 30, 2016
This is version 152 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome 14
    Human chromosome 14: entries, gene names and cross-references to MIM
  2. Human entries with polymorphisms or disease mutations
    List of human entries with polymorphisms or disease mutations
  3. Human polymorphisms and disease mutations
    Index of human polymorphisms and disease mutations
  4. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  5. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.