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Q92692

- PVRL2_HUMAN

UniProt

Q92692 - PVRL2_HUMAN

Protein

Nectin-2

Gene

PVRL2

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 151 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Probable cell adhesion protein.1 Publication

    GO - Molecular functioni

    1. cell adhesion molecule binding Source: BHF-UCL
    2. coreceptor activity Source: ProtInc
    3. identical protein binding Source: IntAct
    4. protein binding Source: UniProtKB
    5. protein homodimerization activity Source: BHF-UCL
    6. virus receptor activity Source: UniProtKB-KW

    GO - Biological processi

    1. acrosome assembly Source: Ensembl
    2. adherens junction organization Source: Reactome
    3. adhesion of symbiont to host Source: BHF-UCL
    4. cell-cell junction organization Source: Reactome
    5. cell junction assembly Source: Reactome
    6. cell part morphogenesis Source: Ensembl
    7. cilium organization Source: Ensembl
    8. coreceptor-mediated virion attachment to host cell Source: BHF-UCL
    9. cytoskeleton organization Source: Ensembl
    10. establishment of mitochondrion localization Source: Ensembl
    11. fertilization Source: Ensembl
    12. fusion of virus membrane with host plasma membrane Source: BHF-UCL
    13. homophilic cell adhesion Source: BHF-UCL
    14. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
    15. positive regulation of mast cell activation Source: BHF-UCL
    16. positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
    17. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
    18. regulation of immune response Source: Reactome
    19. signal transduction Source: GOC
    20. spermatid development Source: BHF-UCL
    21. spermatid nucleus differentiation Source: Ensembl
    22. sperm mitochondrion organization Source: Ensembl
    23. susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
    24. susceptibility to T cell mediated cytotoxicity Source: BHF-UCL

    Keywords - Molecular functioni

    Host cell receptor for virus entry, Receptor

    Keywords - Biological processi

    Cell adhesion, Host-virus interaction

    Enzyme and pathway databases

    ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_19195. Adherens junctions interactions.
    REACT_19268. Nectin/Necl trans heterodimerization.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Nectin-2
    Alternative name(s):
    Herpes virus entry mediator B
    Short name:
    Herpesvirus entry mediator B
    Short name:
    HveB
    Poliovirus receptor-related protein 2
    CD_antigen: CD112
    Gene namesi
    Name:PVRL2
    Synonyms:HVEB, PRR2
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 19

    Organism-specific databases

    HGNCiHGNC:9707. PVRL2.

    Subcellular locationi

    GO - Cellular componenti

    1. cell-cell junction Source: BHF-UCL
    2. cell surface Source: BHF-UCL
    3. extracellular vesicular exosome Source: UniProt
    4. integral component of membrane Source: BHF-UCL
    5. plasma membrane Source: Reactome
    6. zonula adherens Source: BHF-UCL

    Keywords - Cellular componenti

    Cell membrane, Membrane

    Pathology & Biotechi

    Mutagenesis

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Mutagenesisi81 – 811N → A: Abolishes homodimerization. 1 Publication
    Mutagenesisi89 – 891M → F: Loss of entry of HHV-1/Rid1 and HSV-2. No effect on PRV entry. 1 Publication
    Mutagenesisi89 – 891M → I: Increased entry of HHV-1/Rid1 and HSV-2. 1 Publication

    Organism-specific databases

    PharmGKBiPA34052.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 3131Sequence AnalysisAdd
    BLAST
    Chaini32 – 538507Nectin-2PRO_0000015136Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi54 ↔ 1401 PublicationPROSITE-ProRule annotation
    Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi183 ↔ 238PROSITE-ProRule annotation
    Disulfide bondi283 ↔ 329PROSITE-ProRule annotation
    Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
    Modified residuei433 – 4331Phosphoserine2 Publications

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    MaxQBiQ92692.
    PaxDbiQ92692.
    PRIDEiQ92692.

    PTM databases

    PhosphoSiteiQ92692.

    Expressioni

    Tissue specificityi

    Ubiquitous.

    Gene expression databases

    ArrayExpressiQ92692.
    BgeeiQ92692.
    CleanExiHS_PVRL2.
    GenevestigatoriQ92692.

    Organism-specific databases

    HPAiCAB026138.
    HPA012759.

    Interactioni

    Subunit structurei

    Can form trans-heterodimers with PVRL3/nectin-3 By similarity. Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.By similarity4 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    itself2EBI-718419,EBI-718419
    CD226Q157622EBI-718419,EBI-4314442
    MLLT4P551962EBI-718419,EBI-365875
    PVRL3Q9NQS33EBI-718419,EBI-2826725

    Protein-protein interaction databases

    BioGridi111777. 14 interactions.
    DIPiDIP-41043N.
    IntActiQ92692. 14 interactions.
    MINTiMINT-90946.
    STRINGi9606.ENSP00000252483.

    Structurei

    Secondary structure

    1
    538
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Beta strandi35 – 373
    Beta strandi40 – 434
    Beta strandi50 – 523
    Beta strandi55 – 584
    Beta strandi64 – 718
    Helixi77 – 793
    Beta strandi81 – 866
    Turni87 – 893
    Beta strandi90 – 923
    Beta strandi95 – 984
    Helixi100 – 1023
    Beta strandi103 – 1075
    Turni113 – 1153
    Beta strandi125 – 1273
    Helixi132 – 1343
    Beta strandi136 – 14510
    Beta strandi148 – 15710

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    3R0NX-ray1.30A32-158[»]
    4DFHX-ray1.85A/B32-158[»]
    4DFIX-ray1.80A32-158[»]
    4HZAX-ray1.70A/B32-158[»]
    ProteinModelPortaliQ92692.
    SMRiQ92692. Positions 32-350.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ92692.

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini32 – 360329ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini382 – 538157CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei361 – 38121HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini32 – 156125Ig-like V-typeAdd
    BLAST
    Domaini162 – 25695Ig-like C2-type 1Add
    BLAST
    Domaini261 – 34585Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Belongs to the nectin family.Curated

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149530.
    HOGENOMiHOG000237277.
    HOVERGENiHBG019169.
    InParanoidiQ92692.
    KOiK06531.
    OMAiREVTWLR.
    OrthoDBiEOG7D59N6.
    PhylomeDBiQ92692.
    TreeFamiTF331051.

    Family and domain databases

    Gene3Di2.60.40.10. 3 hits.
    InterProiIPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view]
    SMARTiSM00409. IG. 1 hit.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 3 hits.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform Delta (identifier: Q92692-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV    50
    ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS 100
    ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV 150
    RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL 200
    DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL 250
    IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS 300
    GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP 350
    NTAGAGATGG IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL 400
    EGPPSYKPPT PKAKLEAQEM PSQLFTLGAS EHSPLKTPYF DAGASCTEQE 450
    MPRYHELPTL EERSGPLHPG ATSLGSPIPV PPGPPAVEDV SLDLEDEEGE 500
    EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV 538
    Length:538
    Mass (Da):57,742
    Last modified:February 1, 1997 - v1
    Checksum:i3AE4F83E92F6F624
    GO
    Isoform Alpha (identifier: Q92692-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         351-479: NTAGAGATGG...GATSLGSPIP → RASPRDVGPL...SLISRRAVYV
         480-538: Missing.

    Show »
    Length:479
    Mass (Da):51,359
    Checksum:i870F08D7B9D896F2
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Isoform Alpha (identifier: Q92692-2)
    Sequence conflicti410 – 4101P → L in BAF84019. (PubMed:14702039)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei351 – 479129NTAGA…GSPIP → RASPRDVGPLVWGAVGGTLL VLLLLAGGSLAFILLRVRRR RKSPGGAGGGASGDGGFYDP KAQVLGNGDPVFWTPVVPGP MEPDGKDEEEEEEEEKAEKG LMLPPPPALEDDMESQLDGS LISRRAVYV in isoform Alpha. 4 PublicationsVSP_002628Add
    BLAST
    Alternative sequencei480 – 53859Missing in isoform Alpha. 4 PublicationsVSP_002629Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80038 mRNA. Translation: CAA56342.1.
    AF058448 mRNA. Translation: AAC23797.1.
    AK291330 mRNA. Translation: BAF84019.1.
    CR456818 mRNA. Translation: CAG33099.1.
    CH471126 Genomic DNA. Translation: EAW57298.1.
    BC003091 mRNA. Translation: AAH03091.1.
    AF044968
    , AF044962, AF044963, AF044964, AF044966, AF044967 Genomic DNA. Translation: AAC82348.1.
    AF050154 Genomic DNA. Translation: AAD02503.1.
    CCDSiCCDS12645.1. [Q92692-2]
    CCDS42576.1. [Q92692-1]
    PIRiI68093.
    RefSeqiNP_001036189.1. NM_001042724.1. [Q92692-1]
    NP_002847.1. NM_002856.2. [Q92692-2]
    UniGeneiHs.655455.

    Genome annotation databases

    EnsembliENST00000252483; ENSP00000252483; ENSG00000130202. [Q92692-1]
    ENST00000252485; ENSP00000252485; ENSG00000130202. [Q92692-2]
    GeneIDi5819.
    KEGGihsa:5819.
    UCSCiuc002ozv.3. human. [Q92692-2]
    uc002ozw.1. human. [Q92692-1]

    Polymorphism databases

    DMDMi12643789.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    X80038 mRNA. Translation: CAA56342.1 .
    AF058448 mRNA. Translation: AAC23797.1 .
    AK291330 mRNA. Translation: BAF84019.1 .
    CR456818 mRNA. Translation: CAG33099.1 .
    CH471126 Genomic DNA. Translation: EAW57298.1 .
    BC003091 mRNA. Translation: AAH03091.1 .
    AF044968
    , AF044962 , AF044963 , AF044964 , AF044966 , AF044967 Genomic DNA. Translation: AAC82348.1 .
    AF050154 Genomic DNA. Translation: AAD02503.1 .
    CCDSi CCDS12645.1. [Q92692-2 ]
    CCDS42576.1. [Q92692-1 ]
    PIRi I68093.
    RefSeqi NP_001036189.1. NM_001042724.1. [Q92692-1 ]
    NP_002847.1. NM_002856.2. [Q92692-2 ]
    UniGenei Hs.655455.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    3R0N X-ray 1.30 A 32-158 [» ]
    4DFH X-ray 1.85 A/B 32-158 [» ]
    4DFI X-ray 1.80 A 32-158 [» ]
    4HZA X-ray 1.70 A/B 32-158 [» ]
    ProteinModelPortali Q92692.
    SMRi Q92692. Positions 32-350.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 111777. 14 interactions.
    DIPi DIP-41043N.
    IntActi Q92692. 14 interactions.
    MINTi MINT-90946.
    STRINGi 9606.ENSP00000252483.

    PTM databases

    PhosphoSitei Q92692.

    Polymorphism databases

    DMDMi 12643789.

    Proteomic databases

    MaxQBi Q92692.
    PaxDbi Q92692.
    PRIDEi Q92692.

    Protocols and materials databases

    DNASUi 5819.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000252483 ; ENSP00000252483 ; ENSG00000130202 . [Q92692-1 ]
    ENST00000252485 ; ENSP00000252485 ; ENSG00000130202 . [Q92692-2 ]
    GeneIDi 5819.
    KEGGi hsa:5819.
    UCSCi uc002ozv.3. human. [Q92692-2 ]
    uc002ozw.1. human. [Q92692-1 ]

    Organism-specific databases

    CTDi 5819.
    GeneCardsi GC19P045349.
    HGNCi HGNC:9707. PVRL2.
    HPAi CAB026138.
    HPA012759.
    MIMi 600798. gene.
    neXtProti NX_Q92692.
    PharmGKBi PA34052.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG149530.
    HOGENOMi HOG000237277.
    HOVERGENi HBG019169.
    InParanoidi Q92692.
    KOi K06531.
    OMAi REVTWLR.
    OrthoDBi EOG7D59N6.
    PhylomeDBi Q92692.
    TreeFami TF331051.

    Enzyme and pathway databases

    Reactomei REACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
    REACT_19195. Adherens junctions interactions.
    REACT_19268. Nectin/Necl trans heterodimerization.

    Miscellaneous databases

    ChiTaRSi PVRL2. human.
    EvolutionaryTracei Q92692.
    GeneWikii PVRL2.
    GenomeRNAii 5819.
    NextBioi 22666.
    PROi Q92692.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92692.
    Bgeei Q92692.
    CleanExi HS_PVRL2.
    Genevestigatori Q92692.

    Family and domain databases

    Gene3Di 2.60.40.10. 3 hits.
    InterProi IPR013162. CD80_C2-set.
    IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF08205. C2-set_2. 1 hit.
    PF07686. V-set. 1 hit.
    [Graphical view ]
    SMARTi SM00409. IG. 1 hit.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 3 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene."
      Eberle F., Dubreuil P., Mattei M.-G., Devilard E., Lopez M.
      Gene 159:267-272(1995) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA).
    2. "A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus."
      Warner M.S., Geraghty R.J., Martinez W.M., Montgomery R.I., Whitbeck J.C., Xu R., Eisenberg R.J., Cohen G.H., Spear P.G.
      Virology 246:179-189(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), FUNCTION AS A RECEPTOR FOR MUTANTS OF HHV-1; HHV-2 AND PRV.
    3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Tissue: Tongue.
    4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
      Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
      Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
      Tissue: Brain.
    7. "A transcriptional map in the region of 19q13 derived using direct sequencing and exon trapping."
      Yoshiura K., Murray J.C.
      Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-538.
    8. "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."
      Freitas E.M., Zhang W.J., Lalonde J.P., Tay G.K., Gaudieri S., Ashworth L.K., Van Bockxmeer F.M., Dawkins R.L.
      DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 449-538.
    9. "Structural features of nectin-2 (HveB) required for herpes simplex virus entry."
      Martinez W.M., Spear P.G.
      J. Virol. 75:11185-11195(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH HHV-1 MUTANT RID1; HHV-2 AND PRV GLYCOPROTEIN D, MUTAGENESIS OF MET-89.
    10. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."
      Pende D., Bottino C., Castriconi R., Cantoni C., Marcenaro S., Rivera P., Spaggiari G.M., Dondero A., Carnemolla B., Reymond N., Mingari M.C., Lopez M., Moretta L., Moretta A.
      Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH CD226.
    11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
      Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
      Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    13. "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
      Yu X., Harden K., Gonzalez L.C., Francesco M., Chiang E., Irving B., Tom I., Ivelja S., Refino C.J., Clark H., Eaton D., Grogan J.L.
      Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: INTERACTION WITH TIGIT.
    14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    15. "Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion."
      Samanta D., Ramagopal U.A., Rubinstein R., Vigdorovich V., Nathenson S.G., Almo S.C.
      Proc. Natl. Acad. Sci. U.S.A. 109:14836-14840(2012) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 32-158, SUBUNIT, DISULFIDE BOND, MUTAGENESIS OF ASN-81.

    Entry informationi

    Entry nameiPVRL2_HUMAN
    AccessioniPrimary (citable) accession number: Q92692
    Secondary accession number(s): A8K5L5
    , O75455, Q6IBI6, Q96J29
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: January 11, 2001
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 151 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. Human cell differentiation molecules
      CD nomenclature of surface proteins of human leucocytes and list of entries
    2. Human chromosome 19
      Human chromosome 19: entries, gene names and cross-references to MIM
    3. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    4. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    5. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3