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Protein

Nectin-2

Gene

PVRL2

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Probable cell adhesion protein.1 Publication

GO - Molecular functioni

  1. cell adhesion molecule binding Source: BHF-UCL
  2. coreceptor activity Source: ProtInc
  3. identical protein binding Source: IntAct
  4. protein homodimerization activity Source: BHF-UCL
  5. virus receptor activity Source: UniProtKB-KW

GO - Biological processi

  1. acrosome assembly Source: Ensembl
  2. adherens junction organization Source: Reactome
  3. adhesion of symbiont to host Source: BHF-UCL
  4. cell-cell junction organization Source: Reactome
  5. cell junction assembly Source: Reactome
  6. cell part morphogenesis Source: Ensembl
  7. cilium organization Source: Ensembl
  8. coreceptor-mediated virion attachment to host cell Source: BHF-UCL
  9. cytoskeleton organization Source: Ensembl
  10. establishment of mitochondrion localization Source: Ensembl
  11. fertilization Source: Ensembl
  12. fusion of virus membrane with host plasma membrane Source: BHF-UCL
  13. homophilic cell adhesion via plasma membrane adhesion molecules Source: BHF-UCL
  14. positive regulation of immunoglobulin mediated immune response Source: BHF-UCL
  15. positive regulation of mast cell activation Source: BHF-UCL
  16. positive regulation of natural killer cell mediated cytotoxicity Source: BHF-UCL
  17. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: BHF-UCL
  18. regulation of immune response Source: Reactome
  19. regulation of viral entry into host cell Source: CACAO
  20. signal transduction Source: GOC
  21. spermatid development Source: BHF-UCL
  22. spermatid nucleus differentiation Source: Ensembl
  23. sperm mitochondrion organization Source: Ensembl
  24. susceptibility to natural killer cell mediated cytotoxicity Source: BHF-UCL
  25. susceptibility to T cell mediated cytotoxicity Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Host cell receptor for virus entry, Receptor

Keywords - Biological processi

Cell adhesion, Host-virus interaction

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_19195. Adherens junctions interactions.
REACT_19268. Nectin/Necl trans heterodimerization.

Names & Taxonomyi

Protein namesi
Recommended name:
Nectin-2
Alternative name(s):
Herpes virus entry mediator B
Short name:
Herpesvirus entry mediator B
Short name:
HveB
Poliovirus receptor-related protein 2
CD_antigen: CD112
Gene namesi
Name:PVRL2
Synonyms:HVEB, PRR2
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
ProteomesiUP000005640 Componenti: Chromosome 19

Organism-specific databases

HGNCiHGNC:9707. PVRL2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini32 – 360329ExtracellularSequence AnalysisAdd
BLAST
Transmembranei361 – 38121HelicalSequence AnalysisAdd
BLAST
Topological domaini382 – 538157CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. cell-cell junction Source: BHF-UCL
  2. cell surface Source: BHF-UCL
  3. extracellular vesicular exosome Source: UniProtKB
  4. focal adhesion Source: UniProtKB
  5. integral component of membrane Source: BHF-UCL
  6. plasma membrane Source: Reactome
  7. zonula adherens Source: BHF-UCL
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi81 – 811N → A: Abolishes homodimerization. 1 Publication
Mutagenesisi89 – 891M → F: Loss of entry of HHV-1/Rid1 and HSV-2. No effect on PRV entry. 1 Publication
Mutagenesisi89 – 891M → I: Increased entry of HHV-1/Rid1 and HSV-2. 1 Publication

Organism-specific databases

PharmGKBiPA34052.

Polymorphism and mutation databases

BioMutaiPVRL2.
DMDMi12643789.

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 3131Sequence AnalysisAdd
BLAST
Chaini32 – 538507Nectin-2PRO_0000015136Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi54 ↔ 140PROSITE-ProRule annotation1 Publication
Glycosylationi137 – 1371N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi183 ↔ 238PROSITE-ProRule annotation
Disulfide bondi283 ↔ 329PROSITE-ProRule annotation
Glycosylationi324 – 3241N-linked (GlcNAc...)Sequence Analysis
Modified residuei410 – 4101Phosphothreonine1 Publication
Modified residuei433 – 4331Phosphoserine2 Publications

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

MaxQBiQ92692.
PaxDbiQ92692.
PRIDEiQ92692.

PTM databases

PhosphoSiteiQ92692.

Expressioni

Tissue specificityi

Ubiquitous.

Gene expression databases

BgeeiQ92692.
CleanExiHS_PVRL2.
ExpressionAtlasiQ92692. baseline and differential.
GenevestigatoriQ92692.

Organism-specific databases

HPAiCAB026138.
HPA012759.

Interactioni

Subunit structurei

Can form trans-heterodimers with PVRL3/nectin-3 (By similarity). Interacts with CD226. Binds with low affinity to TIGIT. Interacts with herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV) envelope glycoprotein D; functions as an entry receptor for these viruses.By similarity4 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
itself2EBI-718419,EBI-718419
CD226Q157622EBI-718419,EBI-4314442
KRTAP10-5P603703EBI-718419,EBI-10172150
KRTAP10-7P604093EBI-718419,EBI-10172290
KRTAP5-9P263713EBI-718419,EBI-3958099
MDFIQ997504EBI-718419,EBI-724076
MLLT4P551962EBI-718419,EBI-365875
NOTCH2NLQ7Z3S93EBI-718419,EBI-945833
PVRL3Q9NQS33EBI-718419,EBI-2826725
SIAH1Q8IUQ43EBI-718419,EBI-747107

Protein-protein interaction databases

BioGridi111777. 28 interactions.
DIPiDIP-41043N.
IntActiQ92692. 19 interactions.
MINTiMINT-90946.
STRINGi9606.ENSP00000252483.

Structurei

Secondary structure

1
538
Legend: HelixTurnBeta strand
Show more details
Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Beta strandi35 – 373Combined sources
Beta strandi40 – 434Combined sources
Beta strandi50 – 523Combined sources
Beta strandi55 – 584Combined sources
Beta strandi64 – 718Combined sources
Helixi77 – 793Combined sources
Beta strandi81 – 866Combined sources
Turni87 – 893Combined sources
Beta strandi90 – 923Combined sources
Beta strandi95 – 984Combined sources
Helixi100 – 1023Combined sources
Beta strandi103 – 1075Combined sources
Turni113 – 1153Combined sources
Beta strandi125 – 1273Combined sources
Helixi132 – 1343Combined sources
Beta strandi136 – 14510Combined sources
Beta strandi148 – 15710Combined sources

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R0NX-ray1.30A32-158[»]
4DFHX-ray1.85A/B32-158[»]
4DFIX-ray1.80A32-158[»]
4HZAX-ray1.70A/B32-158[»]
ProteinModelPortaliQ92692.
SMRiQ92692. Positions 32-350.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ92692.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini32 – 156125Ig-like V-typeAdd
BLAST
Domaini162 – 25695Ig-like C2-type 1Add
BLAST
Domaini261 – 34585Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Belongs to the nectin family.Curated

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149530.
GeneTreeiENSGT00770000120512.
HOGENOMiHOG000237277.
HOVERGENiHBG019169.
InParanoidiQ92692.
KOiK06531.
OMAiTVNLRCA.
OrthoDBiEOG7D59N6.
PhylomeDBiQ92692.
TreeFamiTF331051.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform Delta (identifier: Q92692-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MARAAALLPS RSPPTPLLWP LLLLLLLETG AQDVRVQVLP EVRGQLGGTV
60 70 80 90 100
ELPCHLLPPV PGLYISLVTW QRPDAPANHQ NVAAFHPKMG PSFPSPKPGS
110 120 130 140 150
ERLSFVSAKQ STGQDTEAEL QDATLALHGL TVEDEGNYTC EFATFPKGSV
160 170 180 190 200
RGMTWLRVIA KPKNQAEAQK VTFSQDPTTV ALCISKEGRP PARISWLSSL
210 220 230 240 250
DWEAKETQVS GTLAGTVTVT SRFTLVPSGR ADGVTVTCKV EHESFEEPAL
260 270 280 290 300
IPVTLSVRYP PEVSISGYDD NWYLGRTDAT LSCDVRSNPE PTGYDWSTTS
310 320 330 340 350
GTFPTSAVAQ GSQLVIHAVD SLFNTTFVCT VTNAVGMGRA EQVIFVRETP
360 370 380 390 400
NTAGAGATGG IIGGIIAAII ATAVAATGIL ICRQQRKEQT LQGAEEDEDL
410 420 430 440 450
EGPPSYKPPT PKAKLEAQEM PSQLFTLGAS EHSPLKTPYF DAGASCTEQE
460 470 480 490 500
MPRYHELPTL EERSGPLHPG ATSLGSPIPV PPGPPAVEDV SLDLEDEEGE
510 520 530
EEEEYLDKIN PIYDALSYSS PSDSYQGKGF VMSRAMYV
Length:538
Mass (Da):57,742
Last modified:February 1, 1997 - v1
Checksum:i3AE4F83E92F6F624
GO
Isoform Alpha (identifier: Q92692-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     351-479: NTAGAGATGG...GATSLGSPIP → RASPRDVGPL...SLISRRAVYV
     480-538: Missing.

Note: Contains a phosphoserine at position 470. Contains a phosphoserine at position 465.Curated1 Publication

Show »
Length:479
Mass (Da):51,359
Checksum:i870F08D7B9D896F2
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Isoform Alpha (identifier: Q92692-2)
Sequence conflicti410 – 4101P → L in BAF84019 (PubMed:14702039).Curated1 Publication

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei351 – 479129NTAGA…GSPIP → RASPRDVGPLVWGAVGGTLL VLLLLAGGSLAFILLRVRRR RKSPGGAGGGASGDGGFYDP KAQVLGNGDPVFWTPVVPGP MEPDGKDEEEEEEEEKAEKG LMLPPPPALEDDMESQLDGS LISRRAVYV in isoform Alpha. 4 PublicationsVSP_002628Add
BLAST
Alternative sequencei480 – 53859Missing in isoform Alpha. 4 PublicationsVSP_002629Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80038 mRNA. Translation: CAA56342.1.
AF058448 mRNA. Translation: AAC23797.1.
AK291330 mRNA. Translation: BAF84019.1.
CR456818 mRNA. Translation: CAG33099.1.
CH471126 Genomic DNA. Translation: EAW57298.1.
BC003091 mRNA. Translation: AAH03091.1.
AF044968
, AF044962, AF044963, AF044964, AF044966, AF044967 Genomic DNA. Translation: AAC82348.1.
AF050154 Genomic DNA. Translation: AAD02503.1.
CCDSiCCDS12645.1. [Q92692-2]
CCDS42576.1. [Q92692-1]
PIRiI68093.
RefSeqiNP_001036189.1. NM_001042724.1. [Q92692-1]
NP_002847.1. NM_002856.2. [Q92692-2]
UniGeneiHs.655455.

Genome annotation databases

EnsembliENST00000252483; ENSP00000252483; ENSG00000130202. [Q92692-1]
ENST00000252485; ENSP00000252485; ENSG00000130202. [Q92692-2]
GeneIDi5819.
KEGGihsa:5819.
UCSCiuc002ozv.3. human. [Q92692-2]
uc002ozw.1. human. [Q92692-1]

Polymorphism and mutation databases

BioMutaiPVRL2.

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X80038 mRNA. Translation: CAA56342.1.
AF058448 mRNA. Translation: AAC23797.1.
AK291330 mRNA. Translation: BAF84019.1.
CR456818 mRNA. Translation: CAG33099.1.
CH471126 Genomic DNA. Translation: EAW57298.1.
BC003091 mRNA. Translation: AAH03091.1.
AF044968
, AF044962, AF044963, AF044964, AF044966, AF044967 Genomic DNA. Translation: AAC82348.1.
AF050154 Genomic DNA. Translation: AAD02503.1.
CCDSiCCDS12645.1. [Q92692-2]
CCDS42576.1. [Q92692-1]
PIRiI68093.
RefSeqiNP_001036189.1. NM_001042724.1. [Q92692-1]
NP_002847.1. NM_002856.2. [Q92692-2]
UniGeneiHs.655455.

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
EntryMethodResolution (Å)ChainPositionsPDBsum
3R0NX-ray1.30A32-158[»]
4DFHX-ray1.85A/B32-158[»]
4DFIX-ray1.80A32-158[»]
4HZAX-ray1.70A/B32-158[»]
ProteinModelPortaliQ92692.
SMRiQ92692. Positions 32-350.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi111777. 28 interactions.
DIPiDIP-41043N.
IntActiQ92692. 19 interactions.
MINTiMINT-90946.
STRINGi9606.ENSP00000252483.

PTM databases

PhosphoSiteiQ92692.

Polymorphism and mutation databases

BioMutaiPVRL2.
DMDMi12643789.

Proteomic databases

MaxQBiQ92692.
PaxDbiQ92692.
PRIDEiQ92692.

Protocols and materials databases

DNASUi5819.
Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENST00000252483; ENSP00000252483; ENSG00000130202. [Q92692-1]
ENST00000252485; ENSP00000252485; ENSG00000130202. [Q92692-2]
GeneIDi5819.
KEGGihsa:5819.
UCSCiuc002ozv.3. human. [Q92692-2]
uc002ozw.1. human. [Q92692-1]

Organism-specific databases

CTDi5819.
GeneCardsiGC19P045349.
HGNCiHGNC:9707. PVRL2.
HPAiCAB026138.
HPA012759.
MIMi600798. gene.
neXtProtiNX_Q92692.
PharmGKBiPA34052.
GenAtlasiSearch...

Phylogenomic databases

eggNOGiNOG149530.
GeneTreeiENSGT00770000120512.
HOGENOMiHOG000237277.
HOVERGENiHBG019169.
InParanoidiQ92692.
KOiK06531.
OMAiTVNLRCA.
OrthoDBiEOG7D59N6.
PhylomeDBiQ92692.
TreeFamiTF331051.

Enzyme and pathway databases

ReactomeiREACT_11152. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.
REACT_19195. Adherens junctions interactions.
REACT_19268. Nectin/Necl trans heterodimerization.

Miscellaneous databases

ChiTaRSiPVRL2. human.
EvolutionaryTraceiQ92692.
GeneWikiiPVRL2.
GenomeRNAii5819.
NextBioi22666.
PROiQ92692.
SOURCEiSearch...

Gene expression databases

BgeeiQ92692.
CleanExiHS_PVRL2.
ExpressionAtlasiQ92692. baseline and differential.
GenevestigatoriQ92692.

Family and domain databases

Gene3Di2.60.40.10. 3 hits.
InterProiIPR013162. CD80_C2-set.
IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF08205. C2-set_2. 1 hit.
PF07686. V-set. 1 hit.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 3 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "The human PRR2 gene, related to the human poliovirus receptor gene (PVR), is the true homolog of the murine MPH gene."
    Eberle F., Dubreuil P., Mattei M.-G., Devilard E., Lopez M.
    Gene 159:267-272(1995) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM DELTA).
  2. "A cell surface protein with herpesvirus entry activity (HveB) confers susceptibility to infection by mutants of herpes simplex virus type 1, herpes simplex virus type 2, and pseudorabies virus."
    Warner M.S., Geraghty R.J., Martinez W.M., Montgomery R.I., Whitbeck J.C., Xu R., Eisenberg R.J., Cohen G.H., Spear P.G.
    Virology 246:179-189(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM ALPHA), FUNCTION AS A RECEPTOR FOR MUTANTS OF HHV-1; HHV-2 AND PRV.
  3. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
    Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
    , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
    Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Tongue.
  4. "Cloning of human full open reading frames in Gateway(TM) system entry vector (pDONR201)."
    Ebert L., Schick M., Neubert P., Schatten R., Henze S., Korn B.
    Submitted (JUN-2004) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
  5. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  6. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM ALPHA).
    Tissue: Brain.
  7. "A transcriptional map in the region of 19q13 derived using direct sequencing and exon trapping."
    Yoshiura K., Murray J.C.
    Submitted (JAN-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 31-538.
  8. "Sequencing of 42kb of the APO E-C2 gene cluster reveals a new gene: PEREC1."
    Freitas E.M., Zhang W.J., Lalonde J.P., Tay G.K., Gaudieri S., Ashworth L.K., Van Bockxmeer F.M., Dawkins R.L.
    DNA Seq. 9:89-100(1998) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA] OF 449-538.
  9. "Structural features of nectin-2 (HveB) required for herpes simplex virus entry."
    Martinez W.M., Spear P.G.
    J. Virol. 75:11185-11195(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH HHV-1 MUTANT RID1; HHV-2 AND PRV GLYCOPROTEIN D, MUTAGENESIS OF MET-89.
  10. "PVR (CD155) and Nectin-2 (CD112) as ligands of the human DNAM-1 (CD226) activating receptor: involvement in tumor cell lysis."
    Pende D., Bottino C., Castriconi R., Cantoni C., Marcenaro S., Rivera P., Spaggiari G.M., Dondero A., Carnemolla B., Reymond N., Mingari M.C., Lopez M., Moretta L., Moretta A.
    Mol. Immunol. 42:463-469(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH CD226.
  11. "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks."
    Olsen J.V., Blagoev B., Gnad F., Macek B., Kumar C., Mortensen P., Mann M.
    Cell 127:635-648(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  12. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
    Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
    Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
  13. "The surface protein TIGIT suppresses T cell activation by promoting the generation of mature immunoregulatory dendritic cells."
    Yu X., Harden K., Gonzalez L.C., Francesco M., Chiang E., Irving B., Tom I., Ivelja S., Refino C.J., Clark H., Eaton D., Grogan J.L.
    Nat. Immunol. 10:48-57(2009) [PubMed] [Europe PMC] [Abstract]
    Cited for: INTERACTION WITH TIGIT.
  14. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
    Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
    Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-433, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Cervix carcinoma.
  15. "An enzyme assisted RP-RPLC approach for in-depth analysis of human liver phosphoproteome."
    Bian Y., Song C., Cheng K., Dong M., Wang F., Huang J., Sun D., Wang L., Ye M., Zou H.
    J. Proteomics 96:253-262(2014) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT THR-410, PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-465 AND SER-470 (ISOFORM ALPHA), IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  16. "Structure of Nectin-2 reveals determinants of homophilic and heterophilic interactions that control cell-cell adhesion."
    Samanta D., Ramagopal U.A., Rubinstein R., Vigdorovich V., Nathenson S.G., Almo S.C.
    Proc. Natl. Acad. Sci. U.S.A. 109:14836-14840(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: X-RAY CRYSTALLOGRAPHY (1.3 ANGSTROMS) OF 32-158, SUBUNIT, DISULFIDE BOND, MUTAGENESIS OF ASN-81.

Entry informationi

Entry nameiPVRL2_HUMAN
AccessioniPrimary (citable) accession number: Q92692
Secondary accession number(s): A8K5L5
, O75455, Q6IBI6, Q96J29
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 11, 2001
Last sequence update: February 1, 1997
Last modified: April 29, 2015
This is version 157 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. Human cell differentiation molecules
    CD nomenclature of surface proteins of human leucocytes and list of entries
  2. Human chromosome 19
    Human chromosome 19: entries, gene names and cross-references to MIM
  3. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  4. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  5. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.