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Q92686 (NEUG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 105. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Neurogranin

Short name=Ng
Alternative name(s):
RC3

Cleaved into the following chain:

  1. NEUG(55-78)
Gene names
Name:NRGN
OrganismHomo sapiens (Human) [Reference proteome]
Taxonomic identifier9606 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo

Protein attributes

Sequence length78 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at protein level

General annotation (Comments)

Function

Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium By similarity.

Tissue specificity

In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. Ref.4

Domain

Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation By similarity.

Post-translational modification

Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions By similarity.

Sequence similarities

Belongs to the neurogranin family.

Contains 1 collagen-like domain.

Contains 1 IQ domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 7878Neurogranin
PRO_0000159591
Peptide55 – 7824NEUG(55-78) By similarity
PRO_0000377703

Regions

Domain26 – 4722IQ
Domain48 – 7831Collagen-like

Sites

Site381Crucial for interaction with calmodulin By similarity

Amino acid modifications

Modified residue11N-acetylmethionine Ref.8
Modified residue361Phosphoserine; by PHK and PKC By similarity
Modified residue681Citrulline; partial

Sequences

Sequence LengthMass (Da)Tools
Q92686 [UniParc].

Last modified February 1, 1997. Version 1.
Checksum: 0D6ED790A31D5785

FASTA787,618
        10         20         30         40         50         60 
MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE RGRKGPGPGG 

        70 
PGGAGVARGG AGGGPSGD 

« Hide

References

« Hide 'large scale' references
[1]"Cloning cDNA for human neurogranin."
Mertsalov I.B., Gundelfinger E.D., Tsetlin V.I.
Bioorg. Khim. 22:366-369(1996) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Brain.
[2]"Structure and chromosomal localization of human neurogranin gene."
Mertsalov I.B., Stumm M., Wieacker P., tom Dieck S., Gundelfinger E.D., Tsetlin V.I.
Bioorg. Khim. 23:961-968(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]"Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN)."
Martinez de Arrieta C., Perez Jurado L., Bernal J., Coloma A.
Genomics 41:243-249(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]"Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia."
Chang J.W., Schumacher E., Coulter P.M. II, Vinters H.V., Watson J.B.
J. Neuropathol. Exp. Neurol. 56:1105-1118(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Tissue: Brain cortex.
[5]Mertsalov I.B., Tsetlin V.I.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]"Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
Tissue: Uterus.
[8]"Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[9]"Initial characterization of the human central proteome."
Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J.
BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract]
Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
[10]"Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation."
Jin Z., Fu Z., Yang J., Troncosco J., Everett A.D., Van Eyk J.E.
Proteomics 13:2682-2691(2013) [PubMed] [Europe PMC] [Abstract]
Cited for: CITRULLINATION AT ARG-68.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
Y09689 mRNA. Translation: CAA70867.1.
Y15058, Y15059 Genomic DNA. Translation: CAA75343.1.
X99076, X99075 Genomic DNA. Translation: CAA67533.1.
U89165 mRNA. Translation: AAB49458.1.
AJ317956 Genomic DNA. Translation: CAC37631.1.
BT007325 mRNA. Translation: AAP35989.1.
BC002835 mRNA. Translation: AAH02835.1.
RefSeqNP_001119653.1. NM_001126181.1.
NP_006167.1. NM_006176.2.
UniGeneHs.524116.

3D structure databases

ProteinModelPortalQ92686.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid110956. 5 interactions.
IntActQ92686. 1 interaction.
STRING9606.ENSP00000284292.

PTM databases

PhosphoSiteQ92686.

Polymorphism databases

DMDM2498625.

Proteomic databases

PaxDbQ92686.
PeptideAtlasQ92686.
PRIDEQ92686.

Protocols and materials databases

DNASU4900.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENST00000284292; ENSP00000284292; ENSG00000154146.
ENST00000412681; ENSP00000399591; ENSG00000154146.
GeneID4900.
KEGGhsa:4900.
UCSCuc001qaq.2. human.

Organism-specific databases

CTD4900.
GeneCardsGC11P124609.
HGNCHGNC:8000. NRGN.
HPACAB006908.
HPA038171.
MIM602350. gene.
neXtProtNX_Q92686.
Orphanet3140. Schizophrenia.
PharmGKBPA31779.
GenAtlasSearch...

Phylogenomic databases

eggNOGNOG41420.
HOVERGENHBG000470.
InParanoidQ92686.
OMAQESACSK.
OrthoDBEOG7BCNFV.
PhylomeDBQ92686.
TreeFamTF342962.

Enzyme and pathway databases

SignaLinkQ92686.

Gene expression databases

BgeeQ92686.
CleanExHS_NRGN.
GenevestigatorQ92686.

Family and domain databases

InterProIPR000048. IQ_motif_EF-hand-BS.
[Graphical view]
PfamPF00612. IQ. 1 hit.
[Graphical view]
SMARTSM00015. IQ. 1 hit.
[Graphical view]
PROSITEPS50096. IQ. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

GenomeRNAi4900.
NextBio18859.
PROQ92686.
SOURCESearch...

Entry information

Entry nameNEUG_HUMAN
AccessionPrimary (citable) accession number: Q92686
Entry history
Integrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: February 1, 1997
Last modified: April 16, 2014
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Relevant documents

SIMILARITY comments

Index of protein domains and families

MIM cross-references

Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot

Human chromosome 11

Human chromosome 11: entries, gene names and cross-references to MIM