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Q92686

- NEUG_HUMAN

UniProt

Q92686 - NEUG_HUMAN

Protein

Neurogranin

Gene

NRGN

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at protein leveli
  1. Functioni

    Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei38 – 381Crucial for interaction with calmodulinBy similarity

    GO - Molecular functioni

    1. calmodulin binding Source: ProtInc

    GO - Biological processi

    1. nervous system development Source: ProtInc
    2. signal transduction Source: ProtInc

    Keywords - Ligandi

    Calmodulin-binding

    Enzyme and pathway databases

    SignaLinkiQ92686.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Neurogranin
    Short name:
    Ng
    Alternative name(s):
    RC3
    Cleaved into the following chain:
    Gene namesi
    Name:NRGN
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 11

    Organism-specific databases

    HGNCiHGNC:8000. NRGN.

    Pathology & Biotechi

    Organism-specific databases

    Orphaneti3140. Schizophrenia.
    PharmGKBiPA31779.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 7878NeurograninPRO_0000159591Add
    BLAST
    Peptidei55 – 7824NEUG(55-78)By similarityPRO_0000377703Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionine1 Publication
    Modified residuei36 – 361Phosphoserine; by PHK and PKCBy similarity
    Modified residuei68 – 681Citrulline; partial1 Publication

    Post-translational modificationi

    Phosphorylated at Ser-36 by PHK and PKC, phosphorylation prevents interaction with Calmodulin and interrupts several learning- and memory-associated functions.By similarity

    Keywords - PTMi

    Acetylation, Citrullination, Phosphoprotein

    Proteomic databases

    MaxQBiQ92686.
    PaxDbiQ92686.
    PeptideAtlasiQ92686.
    PRIDEiQ92686.

    PTM databases

    PhosphoSiteiQ92686.

    Expressioni

    Tissue specificityi

    In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease.1 Publication

    Gene expression databases

    BgeeiQ92686.
    CleanExiHS_NRGN.
    GenevestigatoriQ92686.

    Organism-specific databases

    HPAiCAB006908.
    HPA038171.

    Interactioni

    Protein-protein interaction databases

    BioGridi110956. 6 interactions.
    IntActiQ92686. 1 interaction.
    STRINGi9606.ENSP00000284292.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92686.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini26 – 4722IQPROSITE-ProRule annotationAdd
    BLAST
    Domaini48 – 7831Collagen-likeAdd
    BLAST

    Domaini

    Neurogranin is intrinsically unstructured; however, upon binding with CaM, The IQ domain adopts a helical conformation.By similarity

    Sequence similaritiesi

    Belongs to the neurogranin family.Curated
    Contains 1 collagen-like domain.Curated
    Contains 1 IQ domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiNOG41420.
    HOVERGENiHBG000470.
    InParanoidiQ92686.
    OMAiQESACSK.
    OrthoDBiEOG7BCNFV.
    PhylomeDBiQ92686.
    TreeFamiTF342962.

    Family and domain databases

    InterProiIPR000048. IQ_motif_EF-hand-BS.
    [Graphical view]
    PfamiPF00612. IQ. 1 hit.
    [Graphical view]
    SMARTiSM00015. IQ. 1 hit.
    [Graphical view]
    PROSITEiPS50096. IQ. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q92686-1 [UniParc]FASTAAdd to Basket

    « Hide

    MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE   50
    RGRKGPGPGG PGGAGVARGG AGGGPSGD 78
    Length:78
    Mass (Da):7,618
    Last modified:February 1, 1997 - v1
    Checksum:i0D6ED790A31D5785
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09689 mRNA. Translation: CAA70867.1.
    Y15058, Y15059 Genomic DNA. Translation: CAA75343.1.
    X99076, X99075 Genomic DNA. Translation: CAA67533.1.
    U89165 mRNA. Translation: AAB49458.1.
    AJ317956 Genomic DNA. Translation: CAC37631.1.
    BT007325 mRNA. Translation: AAP35989.1.
    BC002835 mRNA. Translation: AAH02835.1.
    CCDSiCCDS8451.1.
    RefSeqiNP_001119653.1. NM_001126181.1.
    NP_006167.1. NM_006176.2.
    UniGeneiHs.524116.

    Genome annotation databases

    EnsembliENST00000284292; ENSP00000284292; ENSG00000154146.
    ENST00000412681; ENSP00000399591; ENSG00000154146.
    GeneIDi4900.
    KEGGihsa:4900.
    UCSCiuc001qaq.2. human.

    Polymorphism databases

    DMDMi2498625.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09689 mRNA. Translation: CAA70867.1 .
    Y15058 , Y15059 Genomic DNA. Translation: CAA75343.1 .
    X99076 , X99075 Genomic DNA. Translation: CAA67533.1 .
    U89165 mRNA. Translation: AAB49458.1 .
    AJ317956 Genomic DNA. Translation: CAC37631.1 .
    BT007325 mRNA. Translation: AAP35989.1 .
    BC002835 mRNA. Translation: AAH02835.1 .
    CCDSi CCDS8451.1.
    RefSeqi NP_001119653.1. NM_001126181.1.
    NP_006167.1. NM_006176.2.
    UniGenei Hs.524116.

    3D structure databases

    ProteinModelPortali Q92686.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 110956. 6 interactions.
    IntActi Q92686. 1 interaction.
    STRINGi 9606.ENSP00000284292.

    PTM databases

    PhosphoSitei Q92686.

    Polymorphism databases

    DMDMi 2498625.

    Proteomic databases

    MaxQBi Q92686.
    PaxDbi Q92686.
    PeptideAtlasi Q92686.
    PRIDEi Q92686.

    Protocols and materials databases

    DNASUi 4900.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000284292 ; ENSP00000284292 ; ENSG00000154146 .
    ENST00000412681 ; ENSP00000399591 ; ENSG00000154146 .
    GeneIDi 4900.
    KEGGi hsa:4900.
    UCSCi uc001qaq.2. human.

    Organism-specific databases

    CTDi 4900.
    GeneCardsi GC11P124609.
    HGNCi HGNC:8000. NRGN.
    HPAi CAB006908.
    HPA038171.
    MIMi 602350. gene.
    neXtProti NX_Q92686.
    Orphaneti 3140. Schizophrenia.
    PharmGKBi PA31779.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG41420.
    HOVERGENi HBG000470.
    InParanoidi Q92686.
    OMAi QESACSK.
    OrthoDBi EOG7BCNFV.
    PhylomeDBi Q92686.
    TreeFami TF342962.

    Enzyme and pathway databases

    SignaLinki Q92686.

    Miscellaneous databases

    GenomeRNAii 4900.
    NextBioi 18859.
    PROi Q92686.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q92686.
    CleanExi HS_NRGN.
    Genevestigatori Q92686.

    Family and domain databases

    InterProi IPR000048. IQ_motif_EF-hand-BS.
    [Graphical view ]
    Pfami PF00612. IQ. 1 hit.
    [Graphical view ]
    SMARTi SM00015. IQ. 1 hit.
    [Graphical view ]
    PROSITEi PS50096. IQ. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Cloning cDNA for human neurogranin."
      Mertsalov I.B., Gundelfinger E.D., Tsetlin V.I.
      Bioorg. Khim. 22:366-369(1996) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Brain.
    2. "Structure and chromosomal localization of human neurogranin gene."
      Mertsalov I.B., Stumm M., Wieacker P., tom Dieck S., Gundelfinger E.D., Tsetlin V.I.
      Bioorg. Khim. 23:961-968(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    3. "Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN)."
      Martinez de Arrieta C., Perez Jurado L., Bernal J., Coloma A.
      Genomics 41:243-249(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    4. "Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia."
      Chang J.W., Schumacher E., Coulter P.M. II, Vinters H.V., Watson J.B.
      J. Neuropathol. Exp. Neurol. 56:1105-1118(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Tissue: Brain cortex.
    5. Mertsalov I.B., Tsetlin V.I.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
    6. "Cloning of human full-length CDSs in BD Creator(TM) system donor vector."
      Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A.
      Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    7. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Uterus.
    8. "Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach."
      Gauci S., Helbig A.O., Slijper M., Krijgsveld J., Heck A.J., Mohammed S.
      Anal. Chem. 81:4493-4501(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: ACETYLATION [LARGE SCALE ANALYSIS] AT MET-1, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    9. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Identification and Characterization of citrulline-modified brain proteins by combining HCD and CID fragmentation."
      Jin Z., Fu Z., Yang J., Troncosco J., Everett A.D., Van Eyk J.E.
      Proteomics 13:2682-2691(2013) [PubMed] [Europe PMC] [Abstract]
      Cited for: CITRULLINATION AT ARG-68.

    Entry informationi

    Entry nameiNEUG_HUMAN
    AccessioniPrimary (citable) accession number: Q92686
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 1, 1997
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 108 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 11
      Human chromosome 11: entries, gene names and cross-references to MIM
    2. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3