Q92686 (NEUG_HUMAN) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Neurogranin
Short name=Ng

Alternative name(s):
RC3

Cleaved into the following chain:

1. NEUG(55-78)

Gene names

Name:

NRGN

Organism

Homo sapiens (Human) [Reference proteome]

Taxonomic identifier

9606 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Primates › Haplorrhini › Simiiformes › Catarrhini › Hominoidea › Hominidae › Homininae › Homo

Protein attributes

Sequence length	78 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at protein level

General annotation (Comments)

Function	Acts as a "third messenger" substrate of protein kinase C-mediated molecular cascades during synaptic development and remodeling. Binds to calmodulin in the absence of calcium By similarity.
Tissue specificity	In the cerebral cortex, found in the cell bodies of neurons in layers II-VI, and in apical and basal dendrites of pyramidal neurons. Is not found in the dendrites in patients with Alzheimer disease. Ref.4
Post-translational modification	Phosphorylated at Ser-36 by PHK By similarity.
Sequence similarities	Belongs to the neurogranin family. Contains 1 collagen-like domain. Contains 1 IQ domain.

Ontologies

Keywords
Ligand	Calmodulin-binding
PTM	Phosphoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	nervous system development Traceable author statement PubMed 10075657. Source: ProtInc signal transduction Traceable author statement PubMed 10075657. Source: ProtInc
Molecular_function	calmodulin binding Traceable author statement PubMed 10075657. Source: ProtInc
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 78	78	Neurogranin		PRO_0000159591
	Peptide	55 – 78	24	NEUG(55-78) By similarity		PRO_0000377703
Regions
	Domain	26 – 47	22	IQ
	Domain	48 – 78	31	Collagen-like
Amino acid modifications
	Modified residue	36	1	Phosphoserine; by PHK and PKC By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q92686 [UniParc]. Last modified February 1, 1997. Version 1. Checksum: 0D6ED790A31D5785	FASTA	78	7,618
	10 20 30 40 50 60 MDCCTENACS KPDDDILDIP LDDPGANAAA AKIQASFRGH MARKKIKSGE RGRKGPGPGG 70 PGGAGVARGG AGGGPSGD

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Cloning cDNA for human neurogranin." Mertsalov I.B., Gundelfinger E.D., Tsetlin V.I. Bioorg. Khim. 22:366-369(1996) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Tissue: Brain.
[2]	"Structure and chromosomal localization of human neurogranin gene." Mertsalov I.B., Stumm M., Wieacker P., tom Dieck S., Gundelfinger E.D., Tsetlin V.I. Bioorg. Khim. 23:961-968(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[3]	"Structure, organization, and chromosomal mapping of the human neurogranin gene (NRGN)." Martinez de Arrieta C., Perez Jurado L., Bernal J., Coloma A. Genomics 41:243-249(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[4]	"Dendritic translocation of RC3/neurogranin mRNA in normal aging, Alzheimer disease and fronto-temporal dementia." Chang J.W., Schumacher E., Coulter P.M. II, Vinters H.V., Watson J.B. J. Neuropathol. Exp. Neurol. 56:1105-1118(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY. Tissue: Brain cortex.
[5]	Mertsalov I.B., Tsetlin V.I. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [GENOMIC DNA].
[6]	"Cloning of human full-length CDSs in BD Creator(TM) system donor vector." Kalnine N., Chen X., Rolfs A., Halleck A., Hines L., Eisenstein S., Koundinya M., Raphael J., Moreira D., Kelley T., LaBaer J., Lin Y., Phelan M., Farmer A. Submitted (MAY-2003) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
[7]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Uterus.
[8]	"Initial characterization of the human central proteome." Burkard T.R., Planyavsky M., Kaupe I., Breitwieser F.P., Buerckstuemmer T., Bennett K.L., Superti-Furga G., Colinge J. BMC Syst. Biol. 5:17-17(2011) [PubMed] [Europe PMC] [Abstract] Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	Y09689 mRNA. Translation: CAA70867.1. Y15058, Y15059 Genomic DNA. Translation: CAA75343.1. X99076, X99075 Genomic DNA. Translation: CAA67533.1. U89165 mRNA. Translation: AAB49458.1. AJ317956 Genomic DNA. Translation: CAC37631.1. BT007325 mRNA. Translation: AAP35989.1. BC002835 mRNA. Translation: AAH02835.1.
IPI	IPI00022640.
RefSeq	NP_001119653.1. NM_001126181.1. NP_006167.1. NM_006176.2.
UniGene	Hs.524116.
3D structure databases
ProteinModelPortal	Q92686.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q92686. 1 interaction.
STRING	9606.ENSP00000284292.
PTM databases
PhosphoSite	Q92686.
Polymorphism databases
DMDM	2498625.
Proteomic databases
PaxDb	Q92686.
PeptideAtlas	Q92686.
PRIDE	Q92686.
Protocols and materials databases
DNASU	4900.
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENST00000284292; ENSP00000284292; ENSG00000154146. ENST00000412681; ENSP00000399591; ENSG00000154146. ENST00000526916; ENSP00000432255; ENSG00000154146.
GeneID	4900.
KEGG	hsa:4900.
UCSC	uc001qaq.2. human.
Organism-specific databases
CTD	4900.
GeneCards	GC11P124609.
HGNC	HGNC:8000. NRGN.
HPA	CAB006908.
MIM	602350. gene.
neXtProt	NX_Q92686.
PharmGKB	PA31779.
GenAtlas	Search...
Phylogenomic databases
eggNOG	NOG41420.
HOVERGEN	HBG000470.
InParanoid	Q92686.
OMA	KIKSGEH.
OrthoDB	EOG4D26RQ.
Gene expression databases
Bgee	Q92686.
CleanEx	HS_NRGN.
Genevestigator	Q92686.
GermOnline	ENSG00000154146. Homo sapiens.
Family and domain databases
InterPro	IPR000048. IQ_motif_EF-hand-BS. [Graphical view]
Pfam	PF00612. IQ. 1 hit. [Graphical view]
SMART	SM00015. IQ. 1 hit. [Graphical view]
PROSITE	PS50096. IQ. 1 hit. [Graphical view]
ProtoNet	Search...
Other
GenomeRNAi	4900.
NextBio	18859.
SOURCE	Search...

Entry information

Entry name

NEUG_HUMAN

Accession

Primary (citable) accession number: Q92686

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 1, 1997
Last sequence update:	February 1, 1997
Last modified:	April 3, 2013
This is version 97 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.