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Q92685

- ALG3_HUMAN

UniProt

Q92685 - ALG3_HUMAN

Protein

Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase

Gene

ALG3

Organism
Homo sapiens (Human)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 128 (01 Oct 2014)
      Sequence version 1 (01 Feb 1997)
      Previous versions | rss
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    Functioni

    Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man5GlcNAc2-PP-Dol.1 Publication

    Catalytic activityi

    Dolichyl beta-D-mannosyl phosphate + D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol = D-Man-alpha-(1->2)-D-Man-alpha-(1->2)-D-Man-alpha-(1->3)-(D-Man-alpha-(1->3)-D-Man-alpha-(1->6))-D-Man-beta-(1->4)-D-GlcNAc-beta-(1->4)-D-GlcNAc-diphosphodolichol + dolichyl phosphate.

    Pathwayi

    GO - Molecular functioni

    1. alpha-1,3-mannosyltransferase activity Source: UniProtKB
    2. dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase activity Source: UniProtKB-EC

    GO - Biological processi

    1. cellular protein metabolic process Source: Reactome
    2. dolichol-linked oligosaccharide biosynthetic process Source: Reactome
    3. mannosylation Source: GOC
    4. post-translational protein modification Source: Reactome
    5. protein glycosylation Source: UniProtKB
    6. protein N-linked glycosylation via asparagine Source: Reactome

    Keywords - Molecular functioni

    Glycosyltransferase, Transferase

    Enzyme and pathway databases

    ReactomeiREACT_22433. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.
    UniPathwayiUPA00378.

    Protein family/group databases

    CAZyiGT58. Glycosyltransferase Family 58.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferase (EC:2.4.1.258)
    Alternative name(s):
    Asparagine-linked glycosylation protein 3 homolog
    Dol-P-Man-dependent alpha(1-3)-mannosyltransferase
    Dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase
    Dolichyl-phosphate-mannose--glycolipid alpha-mannosyltransferase
    Not56-like protein
    Gene namesi
    Name:ALG3
    Synonyms:NOT, NOT56L
    OrganismiHomo sapiens (Human)
    Taxonomic identifieri9606 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
    ProteomesiUP000005640: Chromosome 3

    Organism-specific databases

    HGNCiHGNC:23056. ALG3.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane

    Pathology & Biotechi

    Involvement in diseasei

    Congenital disorder of glycosylation 1D (CDG1D) [MIM:601110]: A multisystem disorder caused by a defect in glycoprotein biosynthesis and characterized by under-glycosylated serum glycoproteins. Congenital disorders of glycosylation result in a wide variety of clinical features, such as defects in the nervous system development, psychomotor retardation, dysmorphic features, hypotonia, coagulation disorders, and immunodeficiency. The broad spectrum of features reflects the critical role of N-glycoproteins during embryonic development, differentiation, and maintenance of cell functions.2 Publications
    Note: The disease is caused by mutations affecting the gene represented in this entry.
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti118 – 1181G → D in CDG1D. 1 Publication
    Corresponds to variant rs28940588 [ dbSNP | Ensembl ].
    VAR_010306
    Natural varianti171 – 1711R → Q in CDG1D. 1 Publication
    VAR_037806

    Keywords - Diseasei

    Congenital disorder of glycosylation, Disease mutation

    Organism-specific databases

    MIMi601110. phenotype.
    Orphaneti79321. ALG3-CDG.
    PharmGKBiPA134897460.

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 438438Dol-P-Man:Man(5)GlcNAc(2)-PP-Dol alpha-1,3-mannosyltransferasePRO_0000080566Add
    BLAST

    Proteomic databases

    MaxQBiQ92685.
    PaxDbiQ92685.
    PRIDEiQ92685.

    PTM databases

    PhosphoSiteiQ92685.

    Expressioni

    Gene expression databases

    ArrayExpressiQ92685.
    BgeeiQ92685.
    CleanExiHS_ALG3.
    GenevestigatoriQ92685.

    Organism-specific databases

    HPAiHPA045103.

    Interactioni

    Protein-protein interaction databases

    BioGridi115490. 1 interaction.
    IntActiQ92685. 3 interactions.
    STRINGi9606.ENSP00000380793.

    Structurei

    3D structure databases

    ProteinModelPortaliQ92685.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei41 – 6121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei95 – 11521HelicalSequence AnalysisAdd
    BLAST
    Transmembranei123 – 14321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei149 – 16921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei172 – 19221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei203 – 22321HelicalSequence AnalysisAdd
    BLAST
    Transmembranei231 – 25121HelicalSequence AnalysisAdd
    BLAST
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei332 – 35221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei356 – 37621HelicalSequence AnalysisAdd
    BLAST
    Transmembranei407 – 42721HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the glycosyltransferase 58 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG241920.
    HOGENOMiHOG000237555.
    HOVERGENiHBG002070.
    InParanoidiQ92685.
    KOiK03845.
    OMAiAQRWGWG.
    PhylomeDBiQ92685.
    TreeFamiTF105870.

    Family and domain databases

    InterProiIPR007873. Glycosyltransferase_ALG3.
    [Graphical view]
    PANTHERiPTHR12646. PTHR12646. 1 hit.
    PfamiPF05208. ALG3. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q92685-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MAAGLRKRGR SGSAAQAEGL CKQWLQRAWQ ERRLLLREPR YTLLVAACLC    50
    LAEVGITFWV IHRVAYTEID WKAYMAEVEG VINGTYDYTQ LQGDTGPLVY 100
    PAGFVYIFMG LYYATSRGTD IRMAQNIFAV LYLATLLLVF LIYHQTCKVP 150
    PFVFFFMCCA SYRVHSIFVL RLFNDPVAMV LLFLSINLLL AQRWGWGCCF 200
    FSLAVSVKMN VLLFAPGLLF LLLTQFGFRG ALPKLGICAG LQVVLGLPFL 250
    LENPSGYLSR SFDLGRQFLF HWTVNWRFLP EALFLHRAFH LALLTAHLTL 300
    LLLFALCRWH RTGESILSLL RDPSKRKVPP QPLTPNQIVS TLFTSNFIGI 350
    CFSRSLHYQF YVWYFHTLPY LLWAMPARWL THLLRLLVLG LIELSWNTYP 400
    STSCSSAALH ICHAVILLQL WLGPQPFPKS TQHSKKAH 438
    Length:438
    Mass (Da):50,126
    Last modified:February 1, 1997 - v1
    Checksum:i687FC8E4A588FD9C
    GO
    Isoform 2 (identifier: Q92685-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-66: MAAGLRKRGR...TFWVIHRVAY → MFPAQAKENAGFSGCGGD

    Note: No experimental confirmation available.

    Show »
    Length:390
    Mass (Da):44,370
    Checksum:iCCE950E0FFA23449
    GO

    Natural variant

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Natural varianti107 – 1071I → V.
    Corresponds to variant rs2233463 [ dbSNP | Ensembl ].
    VAR_037805
    Natural varianti118 – 1181G → D in CDG1D. 1 Publication
    Corresponds to variant rs28940588 [ dbSNP | Ensembl ].
    VAR_010306
    Natural varianti171 – 1711R → Q in CDG1D. 1 Publication
    VAR_037806

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 6666MAAGL…HRVAY → MFPAQAKENAGFSGCGGD in isoform 2. 1 PublicationVSP_042738Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09022 mRNA. Translation: CAA70220.1.
    AK289361 mRNA. Translation: BAF82050.1.
    AC061705 Genomic DNA. No translation available.
    BC002839 mRNA. Translation: AAH02839.1.
    BC004313 mRNA. Translation: AAH04313.1.
    CCDSiCCDS46967.1. [Q92685-2]
    CCDS46968.1. [Q92685-1]
    RefSeqiNP_001006942.1. NM_001006941.2. [Q92685-2]
    NP_005778.1. NM_005787.5. [Q92685-1]
    UniGeneiHs.478481.

    Genome annotation databases

    EnsembliENST00000397676; ENSP00000380793; ENSG00000214160. [Q92685-1]
    ENST00000445626; ENSP00000402744; ENSG00000214160. [Q92685-2]
    GeneIDi10195.
    KEGGihsa:10195.
    UCSCiuc003fne.2. human. [Q92685-1]
    uc011brc.1. human. [Q92685-2]

    Polymorphism databases

    DMDMi3024226.

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Web resourcesi

    GGDB

    GlycoGene database

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    Y09022 mRNA. Translation: CAA70220.1 .
    AK289361 mRNA. Translation: BAF82050.1 .
    AC061705 Genomic DNA. No translation available.
    BC002839 mRNA. Translation: AAH02839.1 .
    BC004313 mRNA. Translation: AAH04313.1 .
    CCDSi CCDS46967.1. [Q92685-2 ]
    CCDS46968.1. [Q92685-1 ]
    RefSeqi NP_001006942.1. NM_001006941.2. [Q92685-2 ]
    NP_005778.1. NM_005787.5. [Q92685-1 ]
    UniGenei Hs.478481.

    3D structure databases

    ProteinModelPortali Q92685.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 115490. 1 interaction.
    IntActi Q92685. 3 interactions.
    STRINGi 9606.ENSP00000380793.

    Protein family/group databases

    CAZyi GT58. Glycosyltransferase Family 58.

    PTM databases

    PhosphoSitei Q92685.

    Polymorphism databases

    DMDMi 3024226.

    Proteomic databases

    MaxQBi Q92685.
    PaxDbi Q92685.
    PRIDEi Q92685.

    Protocols and materials databases

    DNASUi 10195.
    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENST00000397676 ; ENSP00000380793 ; ENSG00000214160 . [Q92685-1 ]
    ENST00000445626 ; ENSP00000402744 ; ENSG00000214160 . [Q92685-2 ]
    GeneIDi 10195.
    KEGGi hsa:10195.
    UCSCi uc003fne.2. human. [Q92685-1 ]
    uc011brc.1. human. [Q92685-2 ]

    Organism-specific databases

    CTDi 10195.
    GeneCardsi GC03M183960.
    GeneReviewsi ALG3.
    HGNCi HGNC:23056. ALG3.
    HPAi HPA045103.
    MIMi 601110. phenotype.
    608750. gene.
    neXtProti NX_Q92685.
    Orphaneti 79321. ALG3-CDG.
    PharmGKBi PA134897460.
    GenAtlasi Search...

    Phylogenomic databases

    eggNOGi NOG241920.
    HOGENOMi HOG000237555.
    HOVERGENi HBG002070.
    InParanoidi Q92685.
    KOi K03845.
    OMAi AQRWGWG.
    PhylomeDBi Q92685.
    TreeFami TF105870.

    Enzyme and pathway databases

    UniPathwayi UPA00378 .
    Reactomei REACT_22433. Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein.

    Miscellaneous databases

    ChiTaRSi ALG3. human.
    GeneWikii ALG3.
    GenomeRNAii 10195.
    NextBioi 38584.
    PROi Q92685.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q92685.
    Bgeei Q92685.
    CleanExi HS_ALG3.
    Genevestigatori Q92685.

    Family and domain databases

    InterProi IPR007873. Glycosyltransferase_ALG3.
    [Graphical view ]
    PANTHERi PTHR12646. PTHR12646. 1 hit.
    Pfami PF05208. ALG3. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence of the human homologue of the Drosophila melanogaster Not56 protein and its expression in various tissues."
      Kurzik-Dumke U., Kaymer M.
      Submitted (OCT-1996) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Brain.
    2. "Complete sequencing and characterization of 21,243 full-length human cDNAs."
      Ota T., Suzuki Y., Nishikawa T., Otsuki T., Sugiyama T., Irie R., Wakamatsu A., Hayashi K., Sato H., Nagai K., Kimura K., Makita H., Sekine M., Obayashi M., Nishi T., Shibahara T., Tanaka T., Ishii S.
      , Yamamoto J., Saito K., Kawai Y., Isono Y., Nakamura Y., Nagahari K., Murakami K., Yasuda T., Iwayanagi T., Wagatsuma M., Shiratori A., Sudo H., Hosoiri T., Kaku Y., Kodaira H., Kondo H., Sugawara M., Takahashi M., Kanda K., Yokoi T., Furuya T., Kikkawa E., Omura Y., Abe K., Kamihara K., Katsuta N., Sato K., Tanikawa M., Yamazaki M., Ninomiya K., Ishibashi T., Yamashita H., Murakawa K., Fujimori K., Tanai H., Kimata M., Watanabe M., Hiraoka S., Chiba Y., Ishida S., Ono Y., Takiguchi S., Watanabe S., Yosida M., Hotuta T., Kusano J., Kanehori K., Takahashi-Fujii A., Hara H., Tanase T.-O., Nomura Y., Togiya S., Komai F., Hara R., Takeuchi K., Arita M., Imose N., Musashino K., Yuuki H., Oshima A., Sasaki N., Aotsuka S., Yoshikawa Y., Matsunawa H., Ichihara T., Shiohata N., Sano S., Moriya S., Momiyama H., Satoh N., Takami S., Terashima Y., Suzuki O., Nakagawa S., Senoh A., Mizoguchi H., Goto Y., Shimizu F., Wakebe H., Hishigaki H., Watanabe T., Sugiyama A., Takemoto M., Kawakami B., Yamazaki M., Watanabe K., Kumagai A., Itakura S., Fukuzumi Y., Fujimori Y., Komiyama M., Tashiro H., Tanigami A., Fujiwara T., Ono T., Yamada K., Fujii Y., Ozaki K., Hirao M., Ohmori Y., Kawabata A., Hikiji T., Kobatake N., Inagaki H., Ikema Y., Okamoto S., Okitani R., Kawakami T., Noguchi S., Itoh T., Shigeta K., Senba T., Matsumura K., Nakajima Y., Mizuno T., Morinaga M., Sasaki M., Togashi T., Oyama M., Hata H., Watanabe M., Komatsu T., Mizushima-Sugano J., Satoh T., Shirai Y., Takahashi Y., Nakagawa K., Okumura K., Nagase T., Nomura N., Kikuchi H., Masuho Y., Yamashita R., Nakai K., Yada T., Nakamura Y., Ohara O., Isogai T., Sugano S.
      Nat. Genet. 36:40-45(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    3. "The DNA sequence, annotation and analysis of human chromosome 3."
      Muzny D.M., Scherer S.E., Kaul R., Wang J., Yu J., Sudbrak R., Buhay C.J., Chen R., Cree A., Ding Y., Dugan-Rocha S., Gill R., Gunaratne P., Harris R.A., Hawes A.C., Hernandez J., Hodgson A.V., Hume J.
      , Jackson A., Khan Z.M., Kovar-Smith C., Lewis L.R., Lozado R.J., Metzker M.L., Milosavljevic A., Miner G.R., Morgan M.B., Nazareth L.V., Scott G., Sodergren E., Song X.-Z., Steffen D., Wei S., Wheeler D.A., Wright M.W., Worley K.C., Yuan Y., Zhang Z., Adams C.Q., Ansari-Lari M.A., Ayele M., Brown M.J., Chen G., Chen Z., Clendenning J., Clerc-Blankenburg K.P., Chen R., Chen Z., Davis C., Delgado O., Dinh H.H., Dong W., Draper H., Ernst S., Fu G., Gonzalez-Garay M.L., Garcia D.K., Gillett W., Gu J., Hao B., Haugen E., Havlak P., He X., Hennig S., Hu S., Huang W., Jackson L.R., Jacob L.S., Kelly S.H., Kube M., Levy R., Li Z., Liu B., Liu J., Liu W., Lu J., Maheshwari M., Nguyen B.-V., Okwuonu G.O., Palmeiri A., Pasternak S., Perez L.M., Phelps K.A., Plopper F.J., Qiang B., Raymond C., Rodriguez R., Saenphimmachak C., Santibanez J., Shen H., Shen Y., Subramanian S., Tabor P.E., Verduzco D., Waldron L., Wang J., Wang J., Wang Q., Williams G.A., Wong G.K.-S., Yao Z., Zhang J., Zhang X., Zhao G., Zhou J., Zhou Y., Nelson D., Lehrach H., Reinhardt R., Naylor S.L., Yang H., Olson M., Weinstock G., Gibbs R.A.
      Nature 440:1194-1198(2006) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Tissue: Brain and Placenta.
    5. "Carbohydrate deficient glycoprotein syndrome type IV: deficiency of dolichyl-P-Man:Man(5)GlcNAc(2)-PP-dolichyl mannosyltransferase."
      Koerner C., Knauer R., Stephani U., Marquardt T., Lehle L., von Figura K.
      EMBO J. 18:6816-6822(1999) [PubMed] [Europe PMC] [Abstract]
      Cited for: CHARACTERIZATION, VARIANT CDG1D ASP-118, FUNCTION.
    6. "Kinase-selective enrichment enables quantitative phosphoproteomics of the kinome across the cell cycle."
      Daub H., Olsen J.V., Bairlein M., Gnad F., Oppermann F.S., Korner R., Greff Z., Keri G., Stemmann O., Mann M.
      Mol. Cell 31:438-448(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    7. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    8. "Quantitative phosphoproteomics reveals widespread full phosphorylation site occupancy during mitosis."
      Olsen J.V., Vermeulen M., Santamaria A., Kumar C., Miller M.L., Jensen L.J., Gnad F., Cox J., Jensen T.S., Nigg E.A., Brunak S., Mann M.
      Sci. Signal. 3:RA3-RA3(2010) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
      Tissue: Cervix carcinoma.
    9. "System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation."
      Rigbolt K.T., Prokhorova T.A., Akimov V., Henningsen J., Johansen P.T., Kratchmarova I., Kassem M., Mann M., Olsen J.V., Blagoev B.
      Sci. Signal. 4:RS3-RS3(2011) [PubMed] [Europe PMC] [Abstract]
      Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    10. "Congenital disorder of glycosylation Id presenting with hyperinsulinemic hypoglycemia and islet cell hyperplasia."
      Sun L., Eklund E.A., Chung W.K., Wang C., Cohen J., Freeze H.H.
      J. Clin. Endocrinol. Metab. 90:4371-4375(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: VARIANT CDG1D GLN-171.

    Entry informationi

    Entry nameiALG3_HUMAN
    AccessioniPrimary (citable) accession number: Q92685
    Secondary accession number(s): A8JZZ6, Q9BT71
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 15, 1998
    Last sequence update: February 1, 1997
    Last modified: October 1, 2014
    This is version 128 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program
    DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Human chromosome 3
      Human chromosome 3: entries, gene names and cross-references to MIM
    2. Human entries with polymorphisms or disease mutations
      List of human entries with polymorphisms or disease mutations
    3. Human polymorphisms and disease mutations
      Index of human polymorphisms and disease mutations
    4. MIM cross-references
      Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
    5. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    6. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3