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Protein

Centromere protein I

Gene

CENPI

Organism
Homo sapiens (Human)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Component of the CENPA-CAD (nucleosome distal) complex, a complex recruited to centromeres which is involved in assembly of kinetochore proteins, mitotic progression and chromosome segregation. May be involved in incorporation of newly synthesized CENPA into centromeres via its interaction with the CENPA-NAC complex. Required for the localization of CENPF, MAD1L1 and MAD2 (MAD2L1 or MAD2L2) to kinetochores. Involved in the response of gonadal tissues to follicle-stimulating hormone.2 Publications

GO - Biological processi

  • CENP-A containing nucleosome assembly Source: Reactome
  • sex differentiation Source: ProtInc

Enzyme and pathway databases

ReactomeiR-HSA-141444 Amplification of signal from unattached kinetochores via a MAD2 inhibitory signal
R-HSA-2467813 Separation of Sister Chromatids
R-HSA-2500257 Resolution of Sister Chromatid Cohesion
R-HSA-5663220 RHO GTPases Activate Formins
R-HSA-606279 Deposition of new CENPA-containing nucleosomes at the centromere
R-HSA-68877 Mitotic Prometaphase

Names & Taxonomyi

Protein namesi
Recommended name:
Centromere protein I
Short name:
CENP-I
Alternative name(s):
FSH primary response protein 1
Follicle-stimulating hormone primary response protein
Interphase centromere complex protein 19
Leucine-rich primary response protein 1
Gene namesi
Name:CENPI
Synonyms:FSHPRH1, ICEN19, LRPR1
OrganismiHomo sapiens (Human)
Taxonomic identifieri9606 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresPrimatesHaplorrhiniCatarrhiniHominidaeHomo
Proteomesi
  • UP000005640 Componenti: Chromosome X

Organism-specific databases

EuPathDBiHostDB:ENSG00000102384.13
HGNCiHGNC:3968 CENPI
MIMi300065 gene
neXtProtiNX_Q92674

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Centromere, Chromosome, Nucleus

Pathology & Biotechi

Organism-specific databases

DisGeNETi2491
OpenTargetsiENSG00000102384
PharmGKBiPA28385

Polymorphism and mutation databases

BioMutaiCENPI
DMDMi77416860

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000873541 – 756Centromere protein IAdd BLAST756

Post-translational modificationi

Sumoylated. Sumoylated form can be polyubiquitinated by RNF4, leading to its degradation. Desumoylation by SENP6 prevents its degradation.1 Publication

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ92674
MaxQBiQ92674
PaxDbiQ92674
PeptideAtlasiQ92674
PRIDEiQ92674

PTM databases

iPTMnetiQ92674
PhosphoSitePlusiQ92674

Expressioni

Inductioni

By follicle-stimulating hormone (FSH).

Gene expression databases

BgeeiENSG00000102384
CleanExiHS_CENPI
ExpressionAtlasiQ92674 baseline and differential
GenevisibleiQ92674 HS

Organism-specific databases

HPAiHPA061297

Interactioni

Subunit structurei

Component of the CENPA-CAD complex, composed of CENPI, CENPK, CENPL, CENPO, CENPP, CENPQ, CENPR and CENPS. The CENPA-CAD complex interacts with the CENPA-NAC complex, at least composed of CENPA, CENPC, CENPH, CENPM, CENPN, CENPT and CENPU. Interacts with SENP6.3 Publications

Binary interactionsi

WithEntry#Exp.IntActNotes
CEP76Q8TAP64EBI-11085153,EBI-742887

Protein-protein interaction databases

BioGridi108769, 16 interactors
CORUMiQ92674
IntActiQ92674, 7 interactors
STRINGi9606.ENSP00000362018

Structurei

3D structure databases

ProteinModelPortaliQ92674
SMRiQ92674
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the CENP-I/CTF3 family.Curated

Phylogenomic databases

eggNOGiENOG410IEZD Eukaryota
ENOG410ZT13 LUCA
GeneTreeiENSGT00390000013235
HOGENOMiHOG000049199
HOVERGENiHBG080256
InParanoidiQ92674
KOiK11501
OMAiYVCHLLY
OrthoDBiEOG091G03AH
PhylomeDBiQ92674
TreeFamiTF101137

Family and domain databases

InterProiView protein in InterPro
IPR012485 CENP-I
PfamiView protein in Pfam
PF07778 CENP-I, 1 hit

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q92674-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MSPQKRVKNV QAQNRTSQGS SSFQTTLSAW KVKQDPSNSK NISKHGQNNP
60 70 80 90 100
VGDYEHADDQ AEEDALQMAV GYFEKGPIKA SQNKDKTLEK HLKTVENVAW
110 120 130 140 150
KNGLASEEID ILLNIALSGK FGNAVNTRIL KCMIPATVIS EDSVVKAVSW
160 170 180 190 200
LCVGKCSGST KVLFYRWLVA MFDFIDRKEQ INLLYGFFFA SLQDDALCPY
210 220 230 240 250
VCHLLYLLTK KENVKPFRVR KLLDLQAKMG MQPHLQALLS LYKFFAPALI
260 270 280 290 300
SVSLPVRKKI YFKNSENLWK TALLAVKQRN RGPSPEPLKL MLGPANVRPL
310 320 330 340 350
KRKWNSLSVI PVLNSSSYTK ECGKKEMSLS DCLNRSGSFP LEQLQSFPQL
360 370 380 390 400
LQNIHCLELP SQMGSVLNNS LLLHYINCVR DEPVLLRFYY WLSQTLQEEC
410 420 430 440 450
IWYKVNNYEH GKEFTNFLDT IIRAECFLQE GFYSCEAFLY KSLPLWDGLC
460 470 480 490 500
CRSQFLQLVS WIPFSSFSEV KPLLFDHLAQ LFFTSTIYFK CSVLQSLKEL
510 520 530 540 550
LQNWLLWLSM DIHMKPVTNS PLETTLGGSM NSVSKLIHYV GWLSTTAMRL
560 570 580 590 600
ESNNTFLLHF ILDFYEKVCD IYINYNLPLV VLFPPGIFYS ALLSLDTSIL
610 620 630 640 650
NQLCFIMHRY RKNLTAAKKN ELVQKTKSEF NFSSKTYQEF NHYLTSMVGC
660 670 680 690 700
LWTSKPFGKG IYIDPEILEK TGVAEYKNSL NVVHHPSFLS YAVSFLLQES
710 720 730 740 750
PEERTVNVSS IRGKKWSWYL DYLFSQGLQG LKLFIRSSVH HSSIPRAEGI

NCNNQY
Length:756
Mass (Da):86,720
Last modified:October 11, 2005 - v2
Checksum:iA3439CF1729D7A66
GO
Isoform 2 (identifier: Q92674-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     523-756: Missing.

Note: No experimental confirmation available.
Show »
Length:522
Mass (Da):59,813
Checksum:iBAB3AA874485BD51
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti262 – 263FK → LQ in CAA65884 (PubMed:8921378).Curated2
Sequence conflicti389Y → H in CAA65884 (PubMed:8921378).Curated1
Sequence conflicti432F → Y in CAA65884 (PubMed:8921378).Curated1
Sequence conflicti450C → S in CAA65884 (PubMed:8921378).Curated1
Sequence conflicti532S → C in CAA65884 (PubMed:8921378).Curated1
Sequence conflicti576N → D in CAA65884 (PubMed:8921378).Curated1
Sequence conflicti642H → Y in CAA65884 (PubMed:8921378).Curated1
Sequence conflicti658G → A in CAA65884 (PubMed:8921378).Curated1

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_015797523 – 756Missing in isoform 2. 1 PublicationAdd BLAST234

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
X97249 mRNA Translation: CAA65884.1
AL109963 Genomic DNA No translation available.
BC012462 mRNA Translation: AAH12462.1
CCDSiCCDS14479.1 [Q92674-1]
CCDS83482.1 [Q92674-2]
RefSeqiNP_001305452.1, NM_001318523.1 [Q92674-2]
NP_006724.2, NM_006733.3 [Q92674-1]
XP_005262168.1, XM_005262111.2 [Q92674-1]
XP_011529196.1, XM_011530894.2 [Q92674-1]
XP_011529197.1, XM_011530895.2 [Q92674-1]
XP_011529199.1, XM_011530897.2 [Q92674-1]
XP_011529201.1, XM_011530899.2 [Q92674-1]
UniGeneiHs.348920
Hs.737663

Genome annotation databases

EnsembliENST00000372926; ENSP00000362017; ENSG00000102384 [Q92674-2]
ENST00000372927; ENSP00000362018; ENSG00000102384 [Q92674-1]
ENST00000423383; ENSP00000399274; ENSG00000102384 [Q92674-1]
GeneIDi2491
KEGGihsa:2491
UCSCiuc004egy.4 human [Q92674-1]

Keywords - Coding sequence diversityi

Alternative splicing

Similar proteinsi

Entry informationi

Entry nameiCENPI_HUMAN
AccessioniPrimary (citable) accession number: Q92674
Secondary accession number(s): Q5JWZ9, Q96ED0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: November 1, 1997
Last sequence update: October 11, 2005
Last modified: May 23, 2018
This is version 147 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program
DisclaimerAny medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care.

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Human chromosome X
    Human chromosome X: entries, gene names and cross-references to MIM
  2. MIM cross-references
    Online Mendelian Inheritance in Man (MIM) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

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